创建日期
2005-11-16 15:48:42 UTC
更新日期
2021-09-14 15:20:01 UTC
二级访问
HMDB0006780
HMDB00265
HMDB06780
描述
Liothyronine is a T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone that is finally delivered and used by the tissues is mainly T3. Liothyronine is mildly toxic by ingestion and is an experimental teratogen. When heated to decomposition it emits toxic fumes of NOx, I(-), and Cl(-) (Sax's Dangerous Properties of Industrial Materials).
同义词
1:3,5,3'-Triiodo-L-thyronine
2:3,5,3'-Triiodothyronine
3:3,5,3'TRIIODOTHYRONINE
4:4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodo-L-phenylalanine
5:L-3,5,3'-Triiodothyronine
6:L-T3
7:Liothyroninum
8:Liotironina
9:O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine
10:T3
11:Tertroxin
12:Tresitope
13:Triiodothyronine
14:3,3',5-Triiodo-L-thyronine
15:Thyrolar
16:3,3',5-Triiodothyronine
17:Cytomel
18:T3 Thyroid hormone
19:Thyroid hormone, T3
20:Liothyronine sodium
21:3,3',5'-Triiodo-L-thyronine
22:3,3',5'-Triiodothyronine
23:4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenylalanine
24:Cyronine
25:L-3,3',5-Triiodo-thyronine
26:L-3,3',5-Triiodothyronine
27:L-3-[4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-alanine
28:L-Liothyronine
29:L-Triiodothyronine
30:Liothyronin
31:Triiodo-L-thyronine
化学名称
(2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid
代谢物结构字符串
N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C=C2)C(I)=C1)C(O)=O
inchi标识符
InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1
印记键
AUYYCJSJGJYCDS-LBPRGKRZSA-N
分类学
description: belongs to the class of organic compounds known as phenylalanine and derivatives. Phenylalanine and derivatives are compounds containing phenylalanine or a derivative thereof resulting from reaction of phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
description:Phenylalanine and derivatives
kingdom:Organic compounds
super_class:Organic acids and derivatives
class:Carboxylic acids and derivatives
sub_class:Amino acids, peptides, and analogues
molecular_framework:Aromatic homomonocyclic compounds
1:1-hydroxy-2-unsubstituted benzenoids
2:Amino acids
3:Amphetamines and derivatives
4:Aralkylamines
5:Aryl iodides
6:Carbonyl compounds
7:Carboxylic acids
8:Diarylethers
9:Diphenylethers
10:Hydrocarbon derivatives
11:Iodobenzenes
12:L-alpha-amino acids
13:Monoalkylamines
14:Monocarboxylic acids and derivatives
15:O-iodophenols
16:Organic oxides
17:Organoiodides
18:Organopnictogen compounds
19:Phenol ethers
20:Phenoxy compounds
21:Phenylpropanoic acids
22:1-hydroxy-2-unsubstituted benzenoid
23:2-halophenol
24:2-iodophenol
25:3-phenylpropanoic-acid
26:Alpha-amino acid
27:Amine
28:Amino acid
29:Amphetamine or derivatives
30:Aralkylamine
31:Aromatic homomonocyclic compound
32:Aryl halide
33:Aryl iodide
34:Benzenoid
35:Carbonyl group
36:Carboxylic acid
37:Diaryl ether
38:Diphenylether
39:Ether
40:Halobenzene
41:Hydrocarbon derivative
42:Iodobenzene
43:L-alpha-amino acid
44:Monocarboxylic acid or derivatives
45:Monocyclic benzene moiety
46:Organic nitrogen compound
47:Organic oxide
48:Organic oxygen compound
49:Organohalogen compound
50:Organoiodide
51:Organonitrogen compound
52:Organooxygen compound
53:Organopnictogen compound
54:Phenol
55:Phenol ether
56:Phenoxy compound
57:Phenylalanine or derivatives
58:Primary aliphatic amine
59:Primary amine
60:2-halophenol
61:Other amino acids
62:iodophenol
63:iodothyronine
64:thyroxine
本体论
term:Physiological effect
definition:The effect on an organism physiology, resulting from its exposure to a chemical.
parent_id:
level:1
type:parent
term:Health effect
definition:A health condition or observation associated with a stimuli or with a biological activity of a chemical.
parent_id:7693
*level:2
type:parent
term:Health condition
definition:A health effect that consists on short or long-term disease, condition, disorder, syndrome or constant abnormality.
parent_id:7694
**level:3
type:parent
term:Anorexia nervosa
definition:An eating disorder characterized by refusal to maintain a healthy body weight, and an obsessive fear of gaining weight due to a distorted self image. (do).
parent_id:7695
***level:4
type:child
synonym:Anorexia
term:Endocrine disorders
definition:Any disorder that affects the endocrine system. it can be neoplastic (carcinoid tumor, neuroendocrine carcinoma, and pheochromocytoma) or non-neoplastic (such as diabetes mellitus, hyperthyroidism, and adrenal gland insufficiency).
parent_id:7695
***level:4
type:parent
term:Disposition
definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.
parent_id:
level:1
type:parent
term:Source
definition:Natural or synthetic origin of a chemical.
parent_id:7724
*level:2
type:parent
term:Endogenous
definition:
parent_id:7735
**level:3
type:child
term:Biological location
definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.
parent_id:7724
*level:2
type:parent
term:Organ and components
definition:An anatomical organizational level including multiple tissues or substructures, which enables a common biological function.
parent_id:7725
**level:3
type:parent
term:Intestine
definition:The portion of the gastrointestinal tract that includes the small and large intestines.
parent_id:7727
***level:4
type:child
term:Testicle
definition:Either of the paired male reproductive glands that produce the male germ cells and the male hormones. (nci).
parent_id:7727
***level:4
type:child
synonym:Testes
synonym:Testis
term:Endocrine gland
definition:
parent_id:7727
***level:4
type:parent
term:Tissue and substructures
definition:An anatomical organizational level including multiple cells yet not comprising a complete organ .
parent_id:7725
**level:3
type:parent
term:Placenta
definition:An organ present in some vertebrates during embryonic gestation that surrounds the fetus and provides it with nutrients and oxygen, facilitates gas and waste exchange between the fetus and mother, and provides parasitic cloaking from the mother's immune system by excretion of neurokinin b. (nci).
parent_id:7729
***level:4
type:child
term:Epidermis
definition:The epithelial portion of the skin (cutis). it consists of the following layers: stratum corneum (horny layer), stratum granulosum (granular layer), stratum spinosum (prickle cell layer), and stratum basale (basal cell layer). (nci).
parent_id:7729
***level:4
type:child
term:Skeletal muscle
definition:Striated muscles that are under voluntary control of the organism. they are connected at either or both ends to a bone and are utilized for locomotion and other movements. (nci).
parent_id:7729
***level:4
type:child
synonym:Striated muscle
term:Adipose tissue
definition:A specialized form of connective tissue consisting primarily of adipocytes (fat cells), surrounded by a meshwork of collagen fibers. (NCI)
parent_id:7729
***level:4
type:child
synonym:Fat tissue
synonym:Body fat
synonym:Adipose
term:Biofluid and excreta
definition:A liquid, semi-solid or solid material originating in the body.
parent_id:7725
**level:3
type:parent
term:Urine
definition:Excretion in liquid state processed by the kidney.
parent_id:7731
***level:4
type:child
term:Saliva
definition:The watery fluid in the mouth made by the salivary glands. saliva moistens food to help digestion and it helps protect the mouth against infections. (nci).
parent_id:7731
***level:4
type:child
term:Blood
definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.
parent_id:7731
***level:4
type:child
term:Subcellular
definition:An anatomical organizational level including a component within a biological cell .
parent_id:7725
**level:3
type:parent
term:Cytoplasm
definition:The portion of the cell contained within the plasma membrane but excluding the nucleus.
parent_id:7730
***level:4
type:child
synonym:Cytoplasma
term:Membrane
definition:
parent_id:7730
***level:4
type:child
term:Cell membrane
definition:A cellular compartment that separates a cellВ interiorВ from its exterior.
parent_id:7730
***level:4
type:child
synonym:Cellular membrane
term:Cell and elements
definition:An anatomical organizational level comprising of a single cell (or a fragment in some exceptions). a cell is defined by its type or function. it is the smallest unit of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid.
parent_id:7725
**level:3
type:parent
term:Extracellular
definition:The space external to the outermost structure of a cell.
parent_id:7732
***level:4
type:child
synonym:Extracellular region
term:Element
definition:
parent_id:7732
***level:4
type:parent
term:Cell
definition:
parent_id:7732
***level:4
type:parent
term:Process
definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.
parent_id:
level:1
type:parent
term:Naturally occurring process
definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.
parent_id:7659
*level:2
type:parent
term:Biological process
definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.
parent_id:7660
**level:3
type:parent
term:Biochemical pathway
definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.
parent_id:7661
***level:4
type:parent
term:Role
definition:The purpose or function assumed by a chemical, either naturally or as intended by humans .
parent_id:
level:1
type:parent
term:Industrial application
definition:The assumed function of a chemical utilized by human.
parent_id:7671
*level:2
type:parent
term:Pharmaceutical industry
definition:A pharmacologic activity for which a chemical substance is utilized owing to its biological role.
parent_id:7678
**level:3
type:parent
term:Pharmaceutical
definition:
parent_id:7679
***level:4
type:child
预测性质
1:
kind:logp
value:0.82
source:ALOGPS
2:
kind:logs
value:-4.52
source:ALOGPS
3:
kind:solubility
value:0.02 g/L
source:ALOGPS
4:
kind:logp
value:2.8
source:ChemAxon
5:
kind:pka_strongest_acidic
value:0.3
source:ChemAxon
6:
kind:pka_strongest_basic
value:9.48
source:ChemAxon
7:
kind:iupac
value:(2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid
source:ChemAxon
8:
kind:average_mass
value:650.9735
source:ChemAxon
9:
kind:mono_mass
value:650.790038137
source:ChemAxon
10:
kind:smiles
value:N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C=C2)C(I)=C1)C(O)=O
source:ChemAxon
11:
kind:formula
value:C15H12I3NO4
source:ChemAxon
12:
kind:inchi
value:InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1
source:ChemAxon
13:
kind:inchikey
value:AUYYCJSJGJYCDS-LBPRGKRZSA-N
source:ChemAxon
14:
kind:polar_surface_area
value:92.78
source:ChemAxon
15:
kind:refractivity
value:113.43
source:ChemAxon
16:
kind:polarizability
value:43.92
source:ChemAxon
17:
kind:rotatable_bond_count
value:5
source:ChemAxon
18:
kind:acceptor_count
value:4
source:ChemAxon
19:
kind:donor_count
value:3
source:ChemAxon
20:
kind:physiological_charge
value:0
source:ChemAxon
21:
kind:formal_charge
value:0
source:ChemAxon
22:
kind:number_of_rings
value:2
source:ChemAxon
23:
kind:bioavailability
value:Yes
source:ChemAxon
24:
kind:rule_of_five
value:No
source:ChemAxon
25:
kind:ghose_filter
value:No
source:ChemAxon
26:
kind:veber_rule
value:No
source:ChemAxon
27:
kind:mddr_like_rule
value:No
source:ChemAxon
1:
type:Specdb::NmrTwoD
spectrum_id:1247
2:
type:Specdb::CMs
spectrum_id:7084
3:
type:Specdb::NmrOneD
spectrum_id:1301
4:
type:Specdb::MsMs
spectrum_id:460
5:
type:Specdb::MsMs
spectrum_id:461
6:
type:Specdb::MsMs
spectrum_id:462
7:
type:Specdb::MsMs
spectrum_id:3846
8:
type:Specdb::MsMs
spectrum_id:3847
9:
type:Specdb::MsMs
spectrum_id:3848
10:
type:Specdb::MsMs
spectrum_id:3849
11:
type:Specdb::MsMs
spectrum_id:3850
12:
type:Specdb::MsMs
spectrum_id:3851
13:
type:Specdb::MsMs
spectrum_id:3852
14:
type:Specdb::MsMs
spectrum_id:3853
15:
type:Specdb::MsMs
spectrum_id:3854
16:
type:Specdb::MsMs
spectrum_id:3855
17:
type:Specdb::MsMs
spectrum_id:251622
18:
type:Specdb::MsMs
spectrum_id:251623
19:
type:Specdb::MsMs
spectrum_id:251624
20:
type:Specdb::MsMs
spectrum_id:271563
21:
type:Specdb::MsMs
spectrum_id:271564
22:
type:Specdb::MsMs
spectrum_id:271565
23:
type:Specdb::MsMs
spectrum_id:438527
24:
type:Specdb::MsMs
spectrum_id:438528
25:
type:Specdb::MsMs
spectrum_id:438529
26:
type:Specdb::MsMs
spectrum_id:438530
27:
type:Specdb::MsMs
spectrum_id:438531
28:
type:Specdb::MsMs
spectrum_id:447095
生物学性质
1:
cellular:(1):Cytoplasm
cellular:(2):Extracellular
cellular:(3):Membrane
2:
biospecimen:(1):Blood
biospecimen:(2):Saliva
biospecimen:(3):Urine
3:
tissue:(1):Adipose Tissue
tissue:(2):Adrenal Gland
tissue:(3):Epidermis
tissue:(4):Fibroblasts
tissue:(5):Intestine
tissue:(6):Neuron
tissue:(7):Placenta
tissue:(8):Platelet
tissue:(9):Skeletal Muscle
tissue:(10):Testis
tissue:(11):Thyroid Gland
4:
[1]:
name:Thyroid hormone synthesis
smpdb_id:SMP00716
kegg_map_id:
[2]:
name:Tyrosine metabolism
smpdb_id:
kegg_map_id:map00350
正常浓度
1:
biospecimen:Blood
concentration_value:0.0029 +/- 0.00019
concentration_units:uM
subject_age:Children (1-13 years old)
subject_sex:Both
subject_condition:Normal
2:
biospecimen:Blood
concentration_value:0.002 +/- 0.0006
concentration_units:uM
subject_age:Adolescent (13-18 years old)
subject_sex:Female
subject_condition:Normal
3:
biospecimen:Blood
concentration_value:0.000013 - 0.000028
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
4:
biospecimen:Blood
concentration_value:0.0000038 - 0.0000060
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
5:
biospecimen:Blood
concentration_value:0.0000031-0.0000077
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Not Specified
subject_condition:Normal
6:
biospecimen:Saliva
concentration_value:0.0 - 1.0
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
异常浓度
1:
biospecimen:Blood
concentration_value:0.0011 +/- 0.00024
concentration_units:uM
patient_age:Children (1-13 years old)
patient_sex:Both
patient_information:Malnutrition (type kwashiorkor and marasmus)
2:
biospecimen:Blood
concentration_value:0.0014 +/- 0.0004
concentration_units:uM
patient_age:Adolescent (13-18 years old)
patient_sex:Female
patient_information:Anorexia nervosa
3:
biospecimen:Blood
concentration_value:0.00169
concentration_units:uM
patient_age:Adult (>18 years old)
patient_sex:Female
patient_information:Adrenal hyperplasia, congenital, due to 3-beta-hydroxysteroid dehydrogenase 2 deficiency
4:
biospecimen:Blood
concentration_value:0.0000041
concentration_units:uM
patient_age:Adult (>18 years old)
patient_sex:Female
patient_information:Proprotein Convertase 1/3 Deficiency
5:
biospecimen:Urine
concentration_value:0.00075 +/- 0.00033
concentration_units:umol/mmol creatinine
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Hyperthyroidism
6:
biospecimen:Urine
concentration_value:0.000014 +/- 0.000015
concentration_units:umol/mmol creatinine
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Hypothyroidism
疾病参考
1:
name:Anorexia nervosa
omim_id:606788
[1]:
reference_text:Capo-chichi CD, Gueant JL, Lefebvre E, Bennani N, Lorentz E, Vidailhet C, Vidailhet M: Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa. Am J Clin Nutr. 1999 Apr;69(4):672-8.
pubmed_id:10197568
[2]:
reference_text:Vierhapper H, Kiss A, Nowotny P, Wiesnagrotzki S, Monder C, Waldhausl W: Metabolism of cortisol in anorexia nervosa. Acta Endocrinol (Copenh). 1990 Jun;122(6):753-8.
pubmed_id:2165347
[3]:
reference_text:Anderson GM, Gerner RH, Cohen DJ, Fairbanks L: Central tryptamine turnover in depression, schizophrenia, and anorexia: measurement of indoleacetic acid in cerebrospinal fluid. Biol Psychiatry. 1984 Oct;19(10):1427-35.
pubmed_id:6518200
2:
name:Adrenal hyperplasia, congenital, due to 3-beta-hydroxysteroid dehydrogenase 2 deficiency
omim_id:201810
[1]:
reference_text:Hattori N, Ishihara T, Moridera K, Hino M, Ikekubo K, Kurahachi H: A case of late-onset congenital adrenal hyperplasia due to partial 3 beta-hydroxysteroid dehydrogenase deficiency. Endocr J. 1993 Feb;40(1):107-9.
pubmed_id:7951484
[2]:
reference_text:Lutfallah C, Wang W, Mason JI, Chang YT, Haider A, Rich B, Castro-Magana M, Copeland KC, David R, Pang S: Newly proposed hormonal criteria via genotypic proof for type II 3beta-hydroxysteroid dehydrogenase deficiency. J Clin Endocrinol Metab. 2002 Jun;87(6):2611-22. doi: 10.1210/jcem.87.6.8615.
pubmed_id:12050224
[3]:
reference_text:Benkert AR, Young M, Robinson D, Hendrickson C, Lee PA, Strauss KA: Severe Salt-Losing 3beta-Hydroxysteroid Dehydrogenase Deficiency: Treatment and Outcomes of HSD3B2 c.35G>A Homozygotes. J Clin Endocrinol Metab. 2015 Aug;100(8):E1105-15. doi: 10.1210/jc.2015-2098. Epub 2015 Jun 16.
pubmed_id:26079780
[4]:
reference_text:Guven A, Polat S: Testicular Adrenal Rest Tumor in Two Brothers with a Novel Mutation in the 3-Beta-Hydroxysteroid Dehydrogenase-2 Gene. J Clin Res Pediatr Endocrinol. 2017 Mar 1;9(1):85-90. doi: 10.4274/jcrpe.3306. Epub 2016 Jul 29.
pubmed_id:27476613
3:
name:Proprotein Convertase 1/3 Deficiency
omim_id:600955
[1]:
reference_text:O'Rahilly S, Gray H, Humphreys PJ, Krook A, Polonsky KS, White A, Gibson S, Taylor K, Carr C: Brief report: impaired processing of prohormones associated with abnormalities of glucose homeostasis and adrenal function. N Engl J Med. 1995 Nov 23;333(21):1386-90. doi: 10.1056/NEJM199511233332104.
pubmed_id:7477119
4:
name:Hyperthyroidism
omim_id:
[1]:
reference_text:Nelson JC, Weiss RM, Lewis JE, Wilcox RB, Palmer FJ: A multiple ligand-binding radioimmunoassay of diiodotyrosine. J Clin Invest. 1974 Feb;53(2):416-22.
pubmed_id:11344555
[2]:
reference_text:Verhelst J, Berwaerts J, Marescau B, Abs R, Neels H, Mahler C, De Deyn PP: Serum creatine, creatinine, and other guanidino compounds in patients with thyroid dysfunction. Metabolism. 1997 Sep;46(9):1063-7.
pubmed_id:9284897
[3]:
reference_text:Chopra IJ, Santini F, Hurd RE, Chua Teco GN: A radioimmunoassay for measurement of thyroxine sulfate. J Clin Endocrinol Metab. 1993 Jan;76(1):145-50.
pubmed_id:8421080
[4]:
reference_text:Chopra IJ, Boado RJ, Geffner DL, Solomon DH: A radioimmunoassay for measurement of thyronine and its acetic acid analog in urine. J Clin Endocrinol Metab. 1988 Sep;67(3):480-7.
pubmed_id:3410934
[5]:
reference_text:Hommel E, Faber J, Kirkegaard C, Siersbaek-Nielsen K, Friis T: Urinary excretion of unconjugated and conjugated 3,5-diiodothyronine. Horm Metab Res. 1985 Feb;17(2):90-2.
pubmed_id:3988241
[6]:
reference_text:Yoshida K, Sakurada T, Kaise N, Yamamoto M, Kaise K, Saito S, Yoshinaga K: Measurement of triiodothyronine in urine. Tohoku J Exp Med. 1980 Dec;132(4):389-95.
pubmed_id:7256725
5:
name:Hypothyroidism
omim_id:
[1]:
reference_text:Sjoberg S, Eriksson M, Nordin C: L-thyroxine treatment and neurotransmitter levels in the cerebrospinal fluid of hypothyroid patients: a pilot study. Eur J Endocrinol. 1998 Nov;139(5):493-7.
pubmed_id:9849813
[2]:
reference_text:Verhelst J, Berwaerts J, Marescau B, Abs R, Neels H, Mahler C, De Deyn PP: Serum creatine, creatinine, and other guanidino compounds in patients with thyroid dysfunction. Metabolism. 1997 Sep;46(9):1063-7.
pubmed_id:9284897
[3]:
reference_text:Chopra IJ, Santini F, Hurd RE, Chua Teco GN: A radioimmunoassay for measurement of thyroxine sulfate. J Clin Endocrinol Metab. 1993 Jan;76(1):145-50.
pubmed_id:8421080
[4]:
reference_text:Hommel E, Faber J, Kirkegaard C, Siersbaek-Nielsen K, Friis T: Urinary excretion of unconjugated and conjugated 3,5-diiodothyronine. Horm Metab Res. 1985 Feb;17(2):90-2.
pubmed_id:3988241
[5]:
reference_text:Yoshida K, Sakurada T, Kaise N, Yamamoto M, Kaise K, Saito S, Yoshinaga K: Measurement of triiodothyronine in urine. Tohoku J Exp Med. 1980 Dec;132(4):389-95.
pubmed_id:7256725
综合参考
Salamonczyk, Grzegorz M.; Oza, Vibha B.; Sih, Charles J. A concise synthesis of thyroxine (T4) and 3,5,3'-triiodo-L-thyronine (T3). Tetrahedron Letters (1997), 38(40), 6965-69
一般参考
1:
protein_accession:HMDBP00276
name:Thyroid peroxidase
uniprot_id:P07202
gene_name:TPO
protein_type:Unknown
2:
protein_accession:HMDBP01061
name:Type I iodothyronine deiodinase
uniprot_id:P49895
gene_name:DIO1
protein_type:Enzyme
3:
protein_accession:HMDBP01062
name:Type II iodothyronine deiodinase
uniprot_id:Q92813
gene_name:DIO2
protein_type:Enzyme
4:
protein_accession:HMDBP01831
name:Transthyretin
uniprot_id:P02766
gene_name:TTR
protein_type:Enzyme
5:
protein_accession:HMDBP02075
name:Serum albumin
uniprot_id:P02768
gene_name:ALB
protein_type:Unknown
6:
protein_accession:HMDBP02886
name:Thyroxine-binding globulin
uniprot_id:P05543
gene_name:SERPINA7
protein_type:Enzyme
7:
protein_accession:HMDBP02896
name:Thyroid hormone receptor beta
uniprot_id:P10828
gene_name:THRB
protein_type:Enzyme
8:
protein_accession:HMDBP09381
name:Type III iodothyronine deiodinase
uniprot_id:P55073
gene_name:DIO3
protein_type:Enzyme
9:
protein_accession:HMDBP10713
name:Thyroid hormone receptor alpha
uniprot_id:P10827
gene_name:THRA
protein_type:Unknown
蛋白质结合
1:
reference_text:Schwartz CE, May MM, Carpenter NJ, Rogers RC, Martin J, Bialer MG, Ward J, Sanabria J, Marsa S, Lewis JA, Echeverri R, Lubs HA, Voeller K, Simensen RJ, Stevenson RE: Allan-Herndon-Dudley syndrome and the monocarboxylate transporter 8 (MCT8) gene. Am J Hum Genet. 2005 Jul;77(1):41-53. Epub 2005 May 11.
pubmed_id:15889350
2:
reference_text:Gil'miiarova FN, Pervova IuV, Radomskaia VM, Gergel' NI, Tarasova SV: [Levels of unified metabolites and thyroid hormones in blood and oral fluid of children with minimal brain dysfunction]. Biomed Khim. 2004 Mar-Apr;50(2):204-10.
pubmed_id:15179829
3:
reference_text:Escobar-Morreale HF, Botella-Carretero JI, Gomez-Bueno M, Galan JM, Barrios V, Sancho J: Thyroid hormone replacement therapy in primary hypothyroidism: a randomized trial comparing L-thyroxine plus liothyronine with L-thyroxine alone. Ann Intern Med. 2005 Mar 15;142(6):412-24.
pubmed_id:15767619
4:
reference_text:Stalenheim EG: Long-term validity of biological markers of psychopathy and criminal recidivism: follow-up 6-8 years after forensic psychiatric investigation. Psychiatry Res. 2004 Jan 1;121(3):281-91.
pubmed_id:14675747
5:
reference_text:Zimmermann-Belsing T, Dreyer M, Holst JJ, Feldt-Rasmussen U: The relationship between the serum leptin concentrations of thyrotoxic patients during treatment and their total fat mass is different from that of normal subjects. Clin Endocrinol (Oxf). 1998 Nov;49(5):589-95.
pubmed_id:10197073
6:
reference_text:Holt PJ: In vitro responses of the epidermis to triiodothyronine. J Invest Dermatol. 1978 Sep;71(3):202-4.
pubmed_id:690484
7:
reference_text:Mizuma H, Murakami M, Mori M: Thyroid hormone activation in human vascular smooth muscle cells: expression of type II iodothyronine deiodinase. Circ Res. 2001 Feb 16;88(3):313-8.
pubmed_id:11179199
8:
reference_text:Himms-Hagen J: Brown adipose tissue thermogenesis: interdisciplinary studies. FASEB J. 1990 Aug;4(11):2890-8.
pubmed_id:2199286
9:
reference_text:Gledhill RF, Dessein PH, Van der Merwe CA: Treatment of Raynaud's phenomenon with triiodothyronine corrects co-existent autonomic dysfunction: preliminary findings. Postgrad Med J. 1992 Apr;68(798):263-7.
pubmed_id:1409189
10:
reference_text:Kassem M, Brixen K, Mosekilde L, Blum WF, Flyvbjerg A: Effects of growth hormone treatment on serum levels of insulin-like growth factors (IGFs) and IGF binding proteins 1-4 in postmenopausal women. Clin Endocrinol (Oxf). 1998 Dec;49(6):747-56.
pubmed_id:10209562
11:
reference_text:Llewellyn L, Ramsurn VP, Wigham T, Sweeney GE, Power DM: Cloning, characterisation and expression of the apolipoprotein A-I gene in the sea bream (Sparus aurata). Biochim Biophys Acta. 1998 Nov 8;1442(2-3):399-404.
pubmed_id:9804999
12:
reference_text:Dutkiewicz S, Witeska A, Nauman A: The deiodination of thyroxine to triiodothyronine in the testes of patients with prostate cancer. Int Urol Nephrol. 1995;27(1):81-5.
pubmed_id:7615374
13:
reference_text:Rosenbaum M, Goldsmith R, Bloomfield D, Magnano A, Weimer L, Heymsfield S, Gallagher D, Mayer L, Murphy E, Leibel RL: Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. J Clin Invest. 2005 Dec;115(12):3579-86.
pubmed_id:16322796
14:
reference_text:Urcelay E, Jareno MA, Menaya J, Parrilla R, Ayuso MS, Martin-Requero A: Cloning and functional characterization of the 5' regulatory region of the human mitochondrial glycerol-3-phosphate dehydrogenase gene. Lack of 3,5,3'-triiodothyronine responsiveness in adipose tissue. Eur J Biochem. 2000 Dec;267(24):7209-17.
pubmed_id:11106433
15:
reference_text:Lebon V, Dufour S, Petersen KF, Ren J, Jucker BM, Slezak LA, Cline GW, Rothman DL, Shulman GI: Effect of triiodothyronine on mitochondrial energy coupling in human skeletal muscle. J Clin Invest. 2001 Sep;108(5):733-7.
pubmed_id:11544279
16:
reference_text:Iwao H, Abe Y: [Expression of the renin and angiotensinogen genes]. Nihon Yakurigaku Zasshi. 1991 Jan;97(1):1-11.
pubmed_id:2045011
17:
reference_text:Calvo R, Obregon MJ, Ruiz de Ona C, Escobar del Rey F, Morreale de Escobar G: Congenital hypothyroidism, as studied in rats. Crucial role of maternal thyroxine but not of 3,5,3'-triiodothyronine in the protection of the fetal brain. J Clin Invest. 1990 Sep;86(3):889-99.
pubmed_id:2394838
18:
reference_text:Haas MJ, Fishman M, Mreyoud A, Mooradian AD: Thyroid hormone responsive protein (THRP) mediates thyroid hormone-induced cytotoxicity in primary neuronal cultures. Exp Brain Res. 2005 Jan;160(4):424-32. Epub 2004 Oct 15.
pubmed_id:15490139