创建日期
2005-11-16 15:48:42 UTC
更新日期
2020-09-15 17:09:00 UTC
名称
Phosphoenolpyruvic acid
描述
Phosphoenolpyruvate (PEP) is an important chemical compound in biochemistry. It has a high energy phosphate bond, and is involved in glycolysis and gluconeogenesis. In glycolysis, PEP is formed by the action of the enzyme enolase on 2-phosphoglycerate. Metabolism of PEP to pyruvate by pyruvate kinase (PK) generates 1 molecule of adenosine triphosphate (ATP) via substrate-level phosphorylation. ATP is one of the major currencies of chemical energy within cells. In gluconeogenesis, PEP is formed from the decarboxylation of oxaloacetate and hydrolysis of 1 guanosine triphosphate molecule. This reaction is catalyzed by the enzyme phosphoenolpyruvate carboxykinase (PEPCK). This reaction is a rate-limiting step in gluconeogenesis. (wikipedia).
同义词
1:2-(Phosphonooxy)-2-propenoic acid
2:2-PHOSPHOENOLPYRUVIC ACID
3:PEP
4:PHOSPHOENOLPYRUVATE
5:2-(Phosphonooxy)-2-propenoate
6:2-PHOSPHOENOLPYRUVate
7:2-Hydroxy-acrylic acid dihydrogen phosphate
8:2-Phosphonooxyprop-2-enoate
9:2-Phosphonooxyprop-2-enoic acid
10:p-enol-Pyruvate
11:PEP (phosphate)
12:Phosphoenolpyruvic acid
化学名称
2-(phosphonooxy)prop-2-enoic acid
传统名称
phosphoenolpyruvic acid
代谢物结构字符串
OC(=O)C(=C)OP(O)(O)=O
inchi标识符
InChI=1S/C3H5O6P/c1-2(3(4)5)9-10(6,7)8/h1H2,(H,4,5)(H2,6,7,8)
印记键
DTBNBXWJWCWCIK-UHFFFAOYSA-N
分类学
description: belongs to the class of organic compounds known as phosphate esters. These are organic compounds containing phosphoric acid ester functional group, with the general structure R1P(=O)(R2)OR3. R1,R2 = O,N, or halogen atom; R3 = organyl group.
description:Phosphate esters
kingdom:Organic compounds
super_class:Organic acids and derivatives
class:Organic phosphoric acids and derivatives
sub_class:Phosphate esters
molecular_framework:Aliphatic acyclic compounds
1:Carbonyl compounds
2:Carboxylic acids
3:Hydrocarbon derivatives
4:Monocarboxylic acids and derivatives
5:Organic oxides
6:Aliphatic acyclic compound
7:Carbonyl group
8:Carboxylic acid
9:Carboxylic acid derivative
10:Hydrocarbon derivative
11:Monocarboxylic acid or derivatives
12:Organic oxide
13:Organic oxygen compound
14:Organooxygen compound
15:Phosphoric acid ester
16:carboxyalkyl phosphate
17:monocarboxylic acid
本体论
term:Disposition
definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.
parent_id:
level:1
type:parent
term:Route of exposure
definition:A mean by which a chemical agent comes in contact with an organism, either under intended or unintended circumstances.
parent_id:7724
*level:2
type:parent
term:Enteral
definition:Chemical exposure via the alimentary canal (mouth to anus).
parent_id:7743
**level:3
type:parent
term:Ingestion
definition:Chemical exposure facilitated by entry through the mouth.
parent_id:7744
***level:4
type:child
synonym:Digestion
term:Source
definition:Natural or synthetic origin of a chemical.
parent_id:7724
*level:2
type:parent
term:Endogenous
definition:
parent_id:7735
**level:3
type:child
term:Food
definition:
parent_id:7735
**level:3
type:child
term:Biological
definition:A living organism (species or a higher taxonomy rank), in which a chemical can be found.
parent_id:7735
**level:3
type:parent
term:Animal
definition:A living organism belonging to the kingdom animalia. it feeds on organic matter, typically having specialized sense organs and nervous system and able to respond rapidly to stimuli.
parent_id:7736
***level:4
type:child
synonym:Fauna
term:Plant
definition:A living organism belonging to the kingdom plantea. typically, it grows in a permanent site, absorbs water and inorganic substances through its roots, and synthesizes nutrients in its leaves by photosynthesis using the green pigment chlorophyll. examples incude trees, shrubs, herbs, grasses, ferns, and mosses.
parent_id:7736
***level:4
type:parent
synonym:Flora
term:Biological location
definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.
parent_id:7724
*level:2
type:parent
term:Tissue and substructures
definition:An anatomical organizational level including multiple cells yet not comprising a complete organ .
parent_id:7725
**level:3
type:parent
term:Placenta
definition:An organ present in some vertebrates during embryonic gestation that surrounds the fetus and provides it with nutrients and oxygen, facilitates gas and waste exchange between the fetus and mother, and provides parasitic cloaking from the mother's immune system by excretion of neurokinin b. (nci).
parent_id:7729
***level:4
type:child
term:Organ and components
definition:An anatomical organizational level including multiple tissues or substructures, which enables a common biological function.
parent_id:7725
**level:3
type:parent
term:Prostate
definition:The male reproductive accessory gland that produces prostatic fluid and is located adjacent to or around the urethra distal to the urinary bladder in mammals. (nci).
parent_id:7727
***level:4
type:child
synonym:Prostate gland
term:Biofluid and excreta
definition:A liquid, semi-solid or solid material originating in the body.
parent_id:7725
**level:3
type:parent
term:Saliva
definition:The watery fluid in the mouth made by the salivary glands. saliva moistens food to help digestion and it helps protect the mouth against infections. (nci).
parent_id:7731
***level:4
type:child
term:Blood
definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.
parent_id:7731
***level:4
type:child
term:Subcellular
definition:An anatomical organizational level including a component within a biological cell .
parent_id:7725
**level:3
type:parent
term:Cytoplasm
definition:The portion of the cell contained within the plasma membrane but excluding the nucleus.
parent_id:7730
***level:4
type:child
synonym:Cytoplasma
term:Mitochondria
definition:
parent_id:7730
***level:4
type:child
term:Process
definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.
parent_id:
level:1
type:parent
term:Naturally occurring process
definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.
parent_id:7659
*level:2
type:parent
term:Biological process
definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.
parent_id:7660
**level:3
type:parent
term:Biochemical pathway
definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.
parent_id:7661
***level:4
type:parent
term:Role
definition:The purpose or function assumed by a chemical, either naturally or as intended by humans .
parent_id:
level:1
type:parent
term:Industrial application
definition:The assumed function of a chemical utilized by human.
parent_id:7671
*level:2
type:parent
term:Pharmaceutical industry
definition:A pharmacologic activity for which a chemical substance is utilized owing to its biological role.
parent_id:7678
**level:3
type:parent
term:Pharmaceutical
definition:
parent_id:7679
***level:4
type:child
预测性质
1:
kind:logp
value:-1.22
source:ALOGPS
2:
kind:logs
value:-1.10
source:ALOGPS
3:
kind:solubility
value:13.2 g/L
source:ALOGPS
4:
kind:logp
value:-0.64
source:ChemAxon
5:
kind:pka_strongest_acidic
value:0.76
source:ChemAxon
6:
kind:iupac
value:2-(phosphonooxy)prop-2-enoic acid
source:ChemAxon
7:
kind:average_mass
value:168.042
source:ChemAxon
8:
kind:mono_mass
value:167.982374404
source:ChemAxon
9:
kind:smiles
value:OC(=O)C(=C)OP(O)(O)=O
source:ChemAxon
10:
kind:formula
value:C3H5O6P
source:ChemAxon
11:
kind:inchi
value:InChI=1S/C3H5O6P/c1-2(3(4)5)9-10(6,7)8/h1H2,(H,4,5)(H2,6,7,8)
source:ChemAxon
12:
kind:inchikey
value:DTBNBXWJWCWCIK-UHFFFAOYSA-N
source:ChemAxon
13:
kind:polar_surface_area
value:104.06
source:ChemAxon
14:
kind:refractivity
value:30.13
source:ChemAxon
15:
kind:polarizability
value:11.57
source:ChemAxon
16:
kind:rotatable_bond_count
value:3
source:ChemAxon
17:
kind:acceptor_count
value:5
source:ChemAxon
18:
kind:donor_count
value:3
source:ChemAxon
19:
kind:physiological_charge
value:-3
source:ChemAxon
20:
kind:formal_charge
value:0
source:ChemAxon
21:
kind:number_of_rings
value:0
source:ChemAxon
22:
kind:bioavailability
value:Yes
source:ChemAxon
23:
kind:rule_of_five
value:Yes
source:ChemAxon
24:
kind:ghose_filter
value:No
source:ChemAxon
25:
kind:veber_rule
value:No
source:ChemAxon
26:
kind:mddr_like_rule
value:No
source:ChemAxon
1:
type:Specdb::NmrTwoD
spectrum_id:1010
2:
type:Specdb::NmrTwoD
spectrum_id:1246
3:
type:Specdb::CMs
spectrum_id:505
4:
type:Specdb::CMs
spectrum_id:2960
5:
type:Specdb::CMs
spectrum_id:30667
6:
type:Specdb::CMs
spectrum_id:37391
7:
type:Specdb::CMs
spectrum_id:168410
8:
type:Specdb::MsMs
spectrum_id:3830
9:
type:Specdb::MsMs
spectrum_id:3831
10:
type:Specdb::MsMs
spectrum_id:3832
11:
type:Specdb::MsMs
spectrum_id:3833
12:
type:Specdb::MsMs
spectrum_id:3834
13:
type:Specdb::MsMs
spectrum_id:3835
14:
type:Specdb::MsMs
spectrum_id:3836
15:
type:Specdb::MsMs
spectrum_id:3837
16:
type:Specdb::MsMs
spectrum_id:3838
17:
type:Specdb::MsMs
spectrum_id:3845
18:
type:Specdb::MsMs
spectrum_id:438235
19:
type:Specdb::MsMs
spectrum_id:438236
20:
type:Specdb::MsMs
spectrum_id:438237
21:
type:Specdb::MsMs
spectrum_id:438238
22:
type:Specdb::MsMs
spectrum_id:438239
23:
type:Specdb::MsMs
spectrum_id:438872
24:
type:Specdb::MsMs
spectrum_id:438873
25:
type:Specdb::MsMs
spectrum_id:438874
26:
type:Specdb::MsMs
spectrum_id:439171
27:
type:Specdb::MsMs
spectrum_id:440088
28:
type:Specdb::MsMs
spectrum_id:440090
29:
type:Specdb::MsMs
spectrum_id:2236434
30:
type:Specdb::MsMs
spectrum_id:2236966
31:
type:Specdb::MsMs
spectrum_id:2238505
32:
type:Specdb::MsMs
spectrum_id:2239059
33:
type:Specdb::NmrOneD
spectrum_id:1298
34:
type:Specdb::NmrOneD
spectrum_id:4820
35:
type:Specdb::NmrOneD
spectrum_id:4821
36:
type:Specdb::NmrOneD
spectrum_id:6342
37:
type:Specdb::NmrOneD
spectrum_id:6343
38:
type:Specdb::NmrOneD
spectrum_id:6344
39:
type:Specdb::NmrOneD
spectrum_id:6345
40:
type:Specdb::NmrOneD
spectrum_id:6346
41:
type:Specdb::NmrOneD
spectrum_id:6347
42:
type:Specdb::NmrOneD
spectrum_id:6348
43:
type:Specdb::NmrOneD
spectrum_id:6349
44:
type:Specdb::NmrOneD
spectrum_id:6350
45:
type:Specdb::NmrOneD
spectrum_id:6351
46:
type:Specdb::NmrOneD
spectrum_id:6352
47:
type:Specdb::NmrOneD
spectrum_id:6353
48:
type:Specdb::NmrOneD
spectrum_id:6354
49:
type:Specdb::NmrOneD
spectrum_id:6355
50:
type:Specdb::NmrOneD
spectrum_id:6356
51:
type:Specdb::NmrOneD
spectrum_id:6357
52:
type:Specdb::NmrOneD
spectrum_id:6358
53:
type:Specdb::NmrOneD
spectrum_id:6359
54:
type:Specdb::NmrOneD
spectrum_id:6360
55:
type:Specdb::NmrOneD
spectrum_id:6361
生物学性质
1:
cellular:(1):Cytoplasm
cellular:(2):Mitochondria
2:
biospecimen:(1):Blood
biospecimen:(2):Cellular Cytoplasm
biospecimen:(3):Saliva
3:
tissue:(1):Placenta
tissue:(2):Prostate
4:
[1]:
name:Amino Sugar Metabolism
smpdb_id:SMP00045
kegg_map_id:map00520
[2]:
name:Fanconi-bickel syndrome
smpdb_id:SMP00572
kegg_map_id:
[3]:
name:Fructose-1,6-diphosphatase deficiency
smpdb_id:SMP00562
kegg_map_id:
[4]:
name:G(M2)-Gangliosidosis: Variant B, Tay-sachs disease
smpdb_id:SMP00534
kegg_map_id:
[5]:
name:Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease
smpdb_id:SMP00374
kegg_map_id:
[6]:
name:Glycogenosis, Type IA. Von gierke disease
smpdb_id:SMP00581
kegg_map_id:
[7]:
name:Glycogenosis, Type IB
smpdb_id:SMP00573
kegg_map_id:
[8]:
name:Glycogenosis, Type IC
smpdb_id:SMP00574
kegg_map_id:
[9]:
name:Glycogenosis, Type VII. Tarui disease
smpdb_id:SMP00531
kegg_map_id:
[10]:
name:Glycolysis / Gluconeogenesis
smpdb_id:
kegg_map_id:map00010
[11]:
name:Glycolysis / Gluconeogenesis
smpdb_id:
kegg_map_id:map00010
[12]:
name:Leigh Syndrome
smpdb_id:SMP00196
kegg_map_id:
[13]:
name:Phosphoenolpyruvate carboxykinase deficiency 1 (PEPCK1)
smpdb_id:SMP00560
kegg_map_id:
[14]:
name:Primary hyperoxaluria II, PH2
smpdb_id:SMP00558
kegg_map_id:
[15]:
name:Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency)
smpdb_id:SMP00334
kegg_map_id:
[16]:
name:Pyruvate Dehydrogenase Complex Deficiency
smpdb_id:SMP00212
kegg_map_id:
[17]:
name:Pyruvate kinase deficiency
smpdb_id:SMP00559
kegg_map_id:
[18]:
name:Pyruvate metabolism
smpdb_id:
kegg_map_id:map00620
[19]:
name:Salla Disease/Infantile Sialic Acid Storage Disease
smpdb_id:SMP00240
kegg_map_id:
[20]:
name:Sialuria or French Type Sialuria
smpdb_id:SMP00216
kegg_map_id:
[21]:
name:Tay-Sachs Disease
smpdb_id:SMP00390
kegg_map_id:
[22]:
name:Triosephosphate isomerase
smpdb_id:SMP00563
kegg_map_id:
[23]:
name:Warburg Effect
smpdb_id:SMP00654
kegg_map_id:
正常浓度
1:
biospecimen:Blood
concentration_value:7.6 +/- 2.9
concentration_units:uM
subject_age:Newborn (0-30 days old)
subject_sex:Both
subject_condition:Normal
2:
biospecimen:Blood
concentration_value:17.4 +/- 3.8
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
3:
biospecimen:Cellular Cytoplasm
concentration_value:17.0 (15.0-19.0)
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
4:
biospecimen:Saliva
concentration_value:2.07 +/- 1.22
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Female
subject_condition:Normal
5:
biospecimen:Saliva
concentration_value:0.219 +/- 0.312
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
6:
biospecimen:Saliva
concentration_value:0.312 +/- 0.332
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Not Specified
subject_condition:Normal
7:
biospecimen:Saliva
concentration_value:0.419 +/- 0.270
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Not Specified
subject_condition:Normal
8:
biospecimen:Saliva
concentration_value:0.463 +/- 0.275
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Female
subject_condition:Normal
异常浓度
1:
biospecimen:Saliva
concentration_value:1.94 +/- 1.62
concentration_units:uM
patient_age:Adult (>18 years old)
patient_sex:Male
patient_information:Alzheimer's disease
2:
biospecimen:Saliva
concentration_value:2.45 +/- 3.70
concentration_units:uM
patient_age:Adult (>18 years old)
patient_sex:Male
patient_information:Frontotemporal lobe dementia
3:
biospecimen:Saliva
concentration_value:2.36 +/- 3.13
concentration_units:uM
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Lewy body disease
疾病参考
1:
name:Alzheimer's disease
omim_id:104300
[1]:
reference_text:Fonteh AN, Harrington RJ, Tsai A, Liao P, Harrington MG: Free amino acid and dipeptide changes in the body fluids from Alzheimer's disease subjects. Amino Acids. 2007 Feb;32(2):213-24. Epub 2006 Oct 10.
pubmed_id:17031479
[2]:
reference_text:Selley ML, Close DR, Stern SE: The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer's disease. Neurobiol Aging. 2002 May-Jun;23(3):383-8.
pubmed_id:11959400
[3]:
reference_text:Shetty HU, Holloway HW, Schapiro MB: Cerebrospinal fluid and plasma distribution of myo-inositol and other polyols in Alzheimer disease. Clin Chem. 1996 Feb;42(2):298-302.
pubmed_id:8595727
[4]:
reference_text:Jia JP, Jia JM, Zhou WD, Xu M, Chu CB, Yan X, Sun YX: Differential acetylcholine and choline concentrations in the cerebrospinal fluid of patients with Alzheimer's disease and vascular dementia. Chin Med J (Engl). 2004 Aug;117(8):1161-4.
pubmed_id:15361288
[5]:
reference_text:Redjems-Bennani N, Jeandel C, Lefebvre E, Blain H, Vidailhet M, Gueant JL: Abnormal substrate levels that depend upon mitochondrial function in cerebrospinal fluid from Alzheimer patients. Gerontology. 1998;44(5):300-4.
pubmed_id:9693263
[6]:
reference_text:Walter A, Korth U, Hilgert M, Hartmann J, Weichel O, Hilgert M, Fassbender K, Schmitt A, Klein J: Glycerophosphocholine is elevated in cerebrospinal fluid of Alzheimer patients. Neurobiol Aging. 2004 Nov-Dec;25(10):1299-303.
pubmed_id:15465626
[7]:
reference_text:Leoni V, Masterman T, Mousavi FS, Wretlind B, Wahlund LO, Diczfalusy U, Hillert J, Bjorkhem I: Diagnostic use of cerebral and extracerebral oxysterols. Clin Chem Lab Med. 2004 Feb;42(2):186-91.
pubmed_id:15061359
[8]:
reference_text:Raskind MA, Peskind ER, Holmes C, Goldstein DS: Patterns of cerebrospinal fluid catechols support increased central noradrenergic responsiveness in aging and Alzheimer's disease. Biol Psychiatry. 1999 Sep 15;46(6):756-65.
pubmed_id:10494443
[9]:
reference_text:Lovell MA, Markesbery WR: Ratio of 8-hydroxyguanine in intact DNA to free 8-hydroxyguanine is increased in Alzheimer disease ventricular cerebrospinal fluid. Arch Neurol. 2001 Mar;58(3):392-6.
pubmed_id:11255442
[10]:
reference_text:Bar KJ, Franke S, Wenda B, Muller S, Kientsch-Engel R, Stein G, Sauer H: Pentosidine and N(epsilon)-(carboxymethyl)-lysine in Alzheimer's disease and vascular dementia. Neurobiol Aging. 2003 Mar-Apr;24(2):333-8.
pubmed_id:12498967
[11]:
reference_text:Serot JM, Barbe F, Arning E, Bottiglieri T, Franck P, Montagne P, Nicolas JP: Homocysteine and methylmalonic acid concentrations in cerebrospinal fluid: relation with age and Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2005 Nov;76(11):1585-7.
pubmed_id:16227558
[12]:
reference_text:Molina JA, Jimenez-Jimenez FJ, Aguilar MV, Meseguer I, Mateos-Vega CJ, Gonzalez-Munoz MJ, de Bustos F, Porta J, Orti-Pareja M, Zurdo M, Barrios E, Martinez-Para MC: Cerebrospinal fluid levels of transition metals in patients with Alzheimer's disease. J Neural Transm (Vienna). 1998;105(4-5):479-88.
pubmed_id:9720975
[13]:
reference_text:Molina JA, Jimenez-Jimenez FJ, Hernanz A, Fernandez-Vivancos E, Medina S, de Bustos F, Gomez-Escalonilla C, Sayed Y: Cerebrospinal fluid levels of thiamine in patients with Alzheimer's disease. J Neural Transm (Vienna). 2002 Jul;109(7-8):1035-44.
pubmed_id:12111441
[14]:
reference_text:Bocca B, Forte G, Petrucci F, Pino A, Marchione F, Bomboi G, Senofonte O, Giubilei F, Alimonti A: Monitoring of chemical elements and oxidative damage in patients affected by Alzheimer's disease. Ann Ist Super Sanita. 2005;41(2):197-203.
pubmed_id:16244393
[15]:
reference_text:Kristensen MO, Gulmann NC, Christensen JE, Ostergaard K, Rasmussen K: Serum cobalamin and methylmalonic acid in Alzheimer dementia. Acta Neurol Scand. 1993 Jun;87(6):475-81.
pubmed_id:8356878
[16]:
reference_text:Abe T, Tohgi H, Isobe C, Murata T, Sato C: Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease. J Neurosci Res. 2002 Nov 1;70(3):447-50.
pubmed_id:12391605
[17]:
reference_text:Reichman ME, Judd JT, Longcope C, Schatzkin A, Clevidence BA, Nair PP, Campbell WS, Taylor PR: Effects of alcohol consumption on plasma and urinary hormone concentrations in premenopausal women. J Natl Cancer Inst. 1993 May 5;85(9):722-7.
pubmed_id:8478958
[18]:
reference_text:Hozumi I, Hasegawa T, Honda A, Ozawa K, Hayashi Y, Hashimoto K, Yamada M, Koumura A, Sakurai T, Kimura A, Tanaka Y, Satoh M, Inuzuka T: Patterns of levels of biological metals in CSF differ among neurodegenerative diseases. J Neurol Sci. 2011 Apr 15;303(1-2):95-9. doi: 10.1016/j.jns.2011.01.003. Epub 2011 Feb 2.
pubmed_id:21292280
[19]:
reference_text:Motawaj M, Peoc'h K, Callebert J, Arrang JM: CSF levels of the histamine metabolite tele-methylhistamine are only slightly decreased in Alzheimer's disease. J Alzheimers Dis. 2010;22(3):861-71. doi: 10.3233/JAD-2010-100381.
pubmed_id:20858978
[20]:
reference_text:Smach MA, Jacob N, Golmard JL, Charfeddine B, Lammouchi T, Ben Othman L, Dridi H, Bennamou S, Limem K: Folate and homocysteine in the cerebrospinal fluid of patients with Alzheimer's disease or dementia: a case control study. Eur Neurol. 2011;65(5):270-8. doi: 10.1159/000326301. Epub 2011 Apr 8.
pubmed_id:21474939
[21]:
reference_text:Linnebank M, Popp J, Smulders Y, Smith D, Semmler A, Farkas M, Kulic L, Cvetanovska G, Blom H, Stoffel-Wagner B, Kolsch H, Weller M, Jessen F: S-adenosylmethionine is decreased in the cerebrospinal fluid of patients with Alzheimer's disease. Neurodegener Dis. 2010;7(6):373-8. doi: 10.1159/000309657. Epub 2010 Jun 3.
pubmed_id:20523031
[22]:
reference_text:Rosler N, Wichart I, Jellinger KA: Clinical significance of neurobiochemical profiles in the lumbar cerebrospinal fluid of Alzheimer's disease patients. J Neural Transm (Vienna). 2001;108(2):231-46.
pubmed_id:11314776
[23]:
reference_text:Sunderland T, Berrettini WH, Molchan SE, Lawlor BA, Martinez RA, Vitiello B, Tariot PN, Cohen RM: Reduced cerebrospinal fluid dynorphin A1-8 in Alzheimer's disease. Biol Psychiatry. 1991 Jul 1;30(1):81-7.
pubmed_id:1716470
[24]:
reference_text:Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6.
pubmed_id:23857558
2:
name:Frontotemporal dementia
omim_id:600274
[1]:
reference_text:Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6.
pubmed_id:23857558
3:
name:Lewy body disease
omim_id:
[1]:
reference_text:Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6.
pubmed_id:23857558
维基百科编号
Phosphoenolpyruvic_acid
代谢途径的数据库编号
PHOSPHO-ENOL-PYRUVATE
综合参考
Simon, Ethan S.; Grabowski, Sven; Whitesides, George M. Preparation of phosphoenolpyruvate from D-(-)-3-phosphoglyceric acid for use in regeneration of ATP. Journal of the American Chemical Society (1989), 111(24), 8920-1.
一般参考
1:
protein_accession:HMDBP00333
name:Sialic acid synthase
uniprot_id:Q9NR45
gene_name:NANS
protein_type:Enzyme
2:
protein_accession:HMDBP00734
name:6-phosphofructokinase type C
uniprot_id:Q01813
gene_name:PFKP
protein_type:Unknown
3:
protein_accession:HMDBP00758
name:6-phosphofructokinase, liver type
uniprot_id:P17858
gene_name:PFKL
protein_type:Unknown
4:
protein_accession:HMDBP00762
name:6-phosphofructokinase, muscle type
uniprot_id:P08237
gene_name:PFKM
protein_type:Unknown
5:
protein_accession:HMDBP00763
name:Pyruvate kinase isozymes M1/M2
uniprot_id:P14618
gene_name:PKM
protein_type:Unknown
6:
protein_accession:HMDBP00765
name:Pyruvate kinase isozymes R/L
uniprot_id:P30613
gene_name:PKLR
protein_type:Unknown
7:
protein_accession:HMDBP00890
name:Phosphoenolpyruvate carboxykinase [GTP], mitochondrial
uniprot_id:Q16822
gene_name:PCK2
protein_type:Unknown
8:
protein_accession:HMDBP00892
name:Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
uniprot_id:P35558
gene_name:PCK1
protein_type:Unknown
9:
protein_accession:HMDBP01085
name:Beta-enolase
uniprot_id:P13929
gene_name:ENO3
protein_type:Unknown
10:
protein_accession:HMDBP01086
name:Gamma-enolase
uniprot_id:P09104
gene_name:ENO2
protein_type:Unknown
11:
protein_accession:HMDBP01087
name:Alpha-enolase
uniprot_id:P06733
gene_name:ENO1
protein_type:Unknown
12:
protein_accession:HMDBP05558
name:Solute carrier organic anion transporter family member 2A1
uniprot_id:Q92959
gene_name:SLCO2A1
protein_type:Transporter
蛋白质结合
1:
reference_text:Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762.
pubmed_id:19212411
2:
reference_text:Nakayama Y, Kinoshita A, Tomita M: Dynamic simulation of red blood cell metabolism and its application to the analysis of a pathological condition. Theor Biol Med Model. 2005 May 9;2:18.
pubmed_id:15882454
3:
reference_text:Krogh P: Role of ochratoxin in disease causation. Food Chem Toxicol. 1992 Mar;30(3):213-24.
pubmed_id:1618445
4:
reference_text:Germaine GR, Tellefson LM: Promotion of Streptococcus mutans glucose transport by human whole saliva and parotid fluid. Infect Immun. 1985 Apr;48(1):7-13.
pubmed_id:3980096
5:
reference_text:Schatzberger P: Maternity services. BMJ. 1992 May 23;304(6838):1382-3.
pubmed_id:1611358
6:
reference_text:Orye E, Verhaaren H, Samuel K, van Mele B: A 46,XX,10Q+ chromosome constitution in a girl. Partial long arm duplication or insertional translocation? Humangenetik. 1975 May 26;28(1):1-8.
pubmed_id:1150258
7:
reference_text:Landau BR, Chandramouli V, Schumann WC, Ekberg K, Kumaran K, Kalhan SC, Wahren J: Estimates of Krebs cycle activity and contributions of gluconeogenesis to hepatic glucose production in fasting healthy subjects and IDDM patients. Diabetologia. 1995 Jul;38(7):831-8.
pubmed_id:7556986
8:
reference_text:Shirokane Y, Nakajima M, Mizusawa K: A new enzymatic assay of urinary guanidinoacetic acid. Clin Chim Acta. 1991 Oct 31;202(3):227-36.
pubmed_id:1667626
9:
reference_text:Tannen RL: Ammonia metabolism. Am J Physiol. 1978 Oct;235(4):F265-77.
pubmed_id:29492
10:
reference_text:Atkin BM, Buist NR, Utter MF, Leiter AB, Banker BQ: Pyruvate carboxylase deficiency and lactic acidosis in a retarded child without Leigh's disease. Pediatr Res. 1979 Feb;13(2):109-16.
pubmed_id:219411
11:
reference_text:Bojarska-Dahlig H, Gloabski T, Dzioegielewska I: [Salts of cyclic erythromycin A carbonate with cinnamic acid derivatives]. Acta Pol Pharm. 1975;32(3):311-7.
pubmed_id:1155186
12:
reference_text:Matsumoto T, van der Auwera P, Watanabe Y, Tanaka M, Ogata N, Naito S, Kumazawa J: Neutrophil function in hyperosmotic NaCl is preserved by phosphoenol pyruvate. Urol Res. 1991;19(4):223-7.
pubmed_id:1656579
13:
reference_text:Cahill GF Jr, Aoki TT: Renal gluconeogenesis and amino-acid metabolism in man. Med Clin North Am. 1975 May;59(3):751-61.
pubmed_id:1092934
14:
reference_text:Beyer C: Creatine measurement in serum and urine with an automated enzymatic method. Clin Chem. 1993 Aug;39(8):1613-9.
pubmed_id:8353946
15:
reference_text:Momeni N, Yoshimoto T, Ryberg B, Sandberg-Wollheim M, Grubb A: Factors influencing analysis of prolyl endopeptidase in human blood and cerebrospinal fluid: increase in assay sensitivity. Scand J Clin Lab Invest. 2003;63(6):387-95.
pubmed_id:14594319
16:
reference_text:Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043.
pubmed_id:32033212