创建日期
2005-11-16 15:48:42 UTC
更新日期
2020-10-09 20:58:47 UTC
描述
Thiosulfate occurs naturally in hot springs and geysers, and is produced by certain biochemical processes. In the body, thiosulfate converts small amounts of cyanide ion into harmless products and plays a role in the biosynthesis of cysteine, a sulfur-containing amino acid that locks proteins into their correct three-dimensional shapes. Thiosulfate is not found in large quantities in nature. Solutions of thiosulfate break down into sulfur, sulfites, and sulfates when exposed to acids, light, metal ions, and bacteria. Thiosulfate is sometimes used as an antidote for cyanide poisoning. It reacts with cyanide to produce sulfite and thiocyanate ions: CN- + S2O32- SCN- + SO32- This reaction is catalyzed by an enzyme produced by cell mitochondria to neutralize small quantities of ingested cyanide (which occurs naturally in cassava root, lima beans, and almonds!). Thiosulfate is an intermediate in several biochemical pathways, including the synthesis of L-cysteine. Thiosulfate is manufactured by some cells by oxidation of elemental sulfur and by degradation of L-cysteine. Use: Photography (fixing agent to dissolve unchanged silver salts from exposed negatives), chrome tanning, removing chlorine in bleaching and papermaking, extraction of silver from its ores, dechlorination of water, mordant, reagent, bleaching, reducing agent in chrome dyeing, sequestrant in salt (up to 0.1%), antidote for cyanide poisoning. (Hawley's Condensed Chemical Dictionary) Source/Synthesis: Synthesis by dehydration of the pentahydrate at 105 degree. Alternatively formed by reaction of S2Cl2 with Na2O2 or by reduction of Na2S2O4 with sodium amalgam Use/Importance: Commercially available Biological Use/Importance: Cyanide antidote often administered with other antidotes, antifungal agent (ChemNetBase) Sodium thiosulfate is a common analytical reagent used in iodometric titration to analyze chlorine, bromine, and sulfide. Other uses are in bleaching paper pulp, bleaching straw, ivory, and bones, for removing chlorine from solutions, silver extraction from its ores, a mordant in dyeing and printing textiles, and as an antidote to cyanide poisoning. Another major application is in photography, where it is used as a fixer to dissolve unchanged silver salts from exposed negatives. (Handbook of Inorganic Chemicals).
同义词
1:[SO2(OH)(SH)]
2:H2S2O3
3:Thiosulfuric acid
4:Thiosulphate
5:Thiosulphuric acid
6:Hydroxidodioxidosulfidosulfuric acid
7:Hydroxidodioxidosulphidosulphate
8:Hydroxidodioxidosulphidosulphuric acid
9:Thiosulfate
化学名称
sulfanesulfonic acid
传统名称
sulfurothioic S-acid
inchi标识符
InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)
印记键
DHCDFWKWKRSZHF-UHFFFAOYSA-N
分类学
description: belongs to the class of inorganic compounds known as non-metal thiosulfates. These are inorganic non-metallic compounds containing a thiosulfate as its largest oxoanion.
description:Non-metal thiosulfates
kingdom:Inorganic compounds
super_class:Homogeneous non-metal compounds
class:Non-metal oxoanionic compounds
sub_class:Non-metal thiosulfates
molecular_framework:
1:Inorganic oxides
2:Inorganic sulfides
3:Inorganic oxide
4:Inorganic sulfide
5:Non-metal thiosulfate
6:thiosulfuric acid
本体论
term:Physiological effect
definition:The effect on an organism physiology, resulting from its exposure to a chemical.
parent_id:
level:1
type:parent
term:Health effect
definition:A health condition or observation associated with a stimuli or with a biological activity of a chemical.
parent_id:7693
*level:2
type:parent
term:Health condition
definition:A health effect that consists on short or long-term disease, condition, disorder, syndrome or constant abnormality.
parent_id:7694
**level:3
type:parent
term:Hydrogen sulfide poisoning
definition:
parent_id:7695
***level:4
type:child
term:Disposition
definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.
parent_id:
level:1
type:parent
term:Source
definition:Natural or synthetic origin of a chemical.
parent_id:7724
*level:2
type:parent
term:Endogenous
definition:
parent_id:7735
**level:3
type:child
term:Biological location
definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.
parent_id:7724
*level:2
type:parent
term:Tissue and substructures
definition:An anatomical organizational level including multiple cells yet not comprising a complete organ .
parent_id:7725
**level:3
type:parent
term:Epidermis
definition:The epithelial portion of the skin (cutis). it consists of the following layers: stratum corneum (horny layer), stratum granulosum (granular layer), stratum spinosum (prickle cell layer), and stratum basale (basal cell layer). (nci).
parent_id:7729
***level:4
type:child
term:Biofluid and excreta
definition:A liquid, semi-solid or solid material originating in the body.
parent_id:7725
**level:3
type:parent
term:Bile
definition:Fluid composed of waste products, bile acids, salts, cholesterol, and electrolytes. it is secreted by the liver parenchyma and stored in the gallbladder. (nci).
parent_id:7731
***level:4
type:child
term:Urine
definition:Excretion in liquid state processed by the kidney.
parent_id:7731
***level:4
type:child
term:Blood
definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.
parent_id:7731
***level:4
type:child
term:Cell and elements
definition:An anatomical organizational level comprising of a single cell (or a fragment in some exceptions). a cell is defined by its type or function. it is the smallest unit of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid.
parent_id:7725
**level:3
type:parent
term:Extracellular
definition:The space external to the outermost structure of a cell.
parent_id:7732
***level:4
type:child
synonym:Extracellular region
term:Subcellular
definition:An anatomical organizational level including a component within a biological cell .
parent_id:7725
**level:3
type:parent
term:Mitochondria
definition:
parent_id:7730
***level:4
type:child
term:Cytoplasm
definition:The portion of the cell contained within the plasma membrane but excluding the nucleus.
parent_id:7730
***level:4
type:child
synonym:Cytoplasma
term:Role
definition:The purpose or function assumed by a chemical, either naturally or as intended by humans .
parent_id:
level:1
type:parent
term:Biological role
definition:The biological function of a chemical. the biological role answers the question how a chemical is involved in molecular processes in an organism. this can include biochemical effects of non-endogenous chemicals, which are also assigned an industrial application such as pharmaceuticals. the biological role is limited to cellular levls, and will not include role at system process level, such as a chemical which has a role in a disease.
parent_id:7671
*level:2
type:parent
term:Osmolyte
definition:A chemical substance that affects osmosis. osmolytes are soluble in the cell or in the fluid between cells, and are utilized by cells during water stress to maintain the cell volume.
parent_id:7672
**level:3
type:child
synonym:Osmolosis agent
term:Molecular messenger
definition: a chemical substance that is involved in transmission of biochemical signals.
parent_id:7672
**level:3
type:parent
term:Signaling molecule
definition:A chemical substance that particpiates in signal transduction processes in a living cell.
parent_id:7677
***level:4
type:child
synonym:Signalling molecule
synonym:Signaling agent
synonym:Cell signaling agent
实验性质
1:
kind:water_solubility
value:861 mg/mL
source:
2:
kind:melting_point
value:48 °C
source:
预测性质
1:
kind:logp
value:-0.096
source:ChemAxon
2:
kind:pka_strongest_acidic
value:-2.3
source:ChemAxon
3:
kind:iupac
value:sulfanesulfonic acid
source:ChemAxon
4:
kind:average_mass
value:114.144
source:ChemAxon
5:
kind:mono_mass
value:113.94453531
source:ChemAxon
6:
kind:smiles
value:OS(S)(=O)=O
source:ChemAxon
7:
kind:formula
value:H2O3S2
source:ChemAxon
8:
kind:inchi
value:InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)
source:ChemAxon
9:
kind:inchikey
value:DHCDFWKWKRSZHF-UHFFFAOYSA-N
source:ChemAxon
10:
kind:polar_surface_area
value:54.37
source:ChemAxon
11:
kind:refractivity
value:17.76
source:ChemAxon
12:
kind:polarizability
value:8.29
source:ChemAxon
13:
kind:rotatable_bond_count
value:0
source:ChemAxon
14:
kind:acceptor_count
value:3
source:ChemAxon
15:
kind:donor_count
value:2
source:ChemAxon
16:
kind:physiological_charge
value:-1
source:ChemAxon
17:
kind:formal_charge
value:0
source:ChemAxon
18:
kind:number_of_rings
value:0
source:ChemAxon
19:
kind:bioavailability
value:Yes
source:ChemAxon
20:
kind:rule_of_five
value:Yes
source:ChemAxon
21:
kind:ghose_filter
value:No
source:ChemAxon
22:
kind:veber_rule
value:No
source:ChemAxon
23:
kind:mddr_like_rule
value:No
source:ChemAxon
生物学性质
1:
cellular:(1):Extracellular
cellular:(2):Mitochondria
2:
biospecimen:(1):Bile
biospecimen:(2):Blood
biospecimen:(3):Urine
3:
tissue:(1):Epidermis
4:
正常浓度
1:
biospecimen:Bile
concentration_value:1215 +/- 261
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Not Specified
subject_condition:Normal
2:
biospecimen:Blood
concentration_value:100.8 +/- 9.811
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
3:
biospecimen:Blood
concentration_value:1.5 (0.0-3.0)
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
4:
biospecimen:Urine
concentration_value:0.470-3.820
concentration_units:umol/mmol creatinine
subject_age:Not Specified
subject_sex:Both
subject_condition:Normal
5:
biospecimen:Urine
concentration_value:2.09 +/- 0.84
concentration_units:umol/mmol creatinine
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
6:
biospecimen:Urine
concentration_value:1.646 +/- 0.118
concentration_units:umol/mmol creatinine
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
异常浓度
1:
biospecimen:Blood
concentration_value:150.0 (110.0-230.0)
concentration_units:uM
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Hydrogen sulfide fatal poisoning
2:
biospecimen:Urine
concentration_value:2.6
concentration_units:umol/mmol creatinine
patient_age:Adult (>18 years old)
patient_sex:Female
patient_information:Beta-mercaptolactate-cysteine Disulfiduria
3:
biospecimen:Urine
concentration_value:53
concentration_units:umol/mmol creatinine
patient_age:Newborn (0-30 days old)
patient_sex:Not Specified
patient_information:Molybdenum cofactor deficiency
4:
biospecimen:Urine
concentration_value:263
concentration_units:umol/mmol creatinine
patient_age:Children (1-13 years old)
patient_sex:Not Specified
patient_information:Molybdenum cofactor deficiency
疾病参考
1:
name:Hydrogen sulfide poisoning
omim_id:
[1]:
reference_text:Kage S, Takekawa K, Kurosaki K, Imamura T, Kudo K: The usefulness of thiosulfate as an indicator of hydrogen sulfide poisoning: three cases. Int J Legal Med. 1997;110(4):220-2.
pubmed_id:9274948
[2]:
reference_text:Kage S, Ikeda H, Ikeda N, Tsujita A, Kudo K: Fatal hydrogen sulfide poisoning at a dye works. Leg Med (Tokyo). 2004 Jul;6(3):182-6.
pubmed_id:15231289
[3]:
reference_text:Daldal H, Beder B, Serin S, Sungurtekin H: Hydrogen sulfide toxicity in a thermal spring: a fatal outcome. Clin Toxicol (Phila). 2010 Aug;48(7):755-6. doi: 10.3109/15563650.2010.508044.
pubmed_id:20704456
[4]:
reference_text:Whiteman M, Haigh R, Tarr JM, Gooding KM, Shore AC, Winyard PG: Detection of hydrogen sulfide in plasma and knee-joint synovial fluid from rheumatoid arthritis patients: relation to clinical and laboratory measures of inflammation. Ann N Y Acad Sci. 2010 Aug;1203:146-50. doi: 10.1111/j.1749-6632.2010.05556.x.
pubmed_id:20716297
2:
name:Molybdenum cofactor deficiency
omim_id:
[1]:
reference_text:Wevers RA, Engelke UF, Moolenaar SH, Brautigam C, de Jong JG, Duran R, de Abreu RA, van Gennip AH: 1H-NMR spectroscopy of body fluids: inborn errors of purine and pyrimidine metabolism. Clin Chem. 1999 Apr;45(4):539-48.
pubmed_id:10102915
[2]:
reference_text:van Gennip AH, Abeling NG, Stroomer AE, Overmars H, Bakker HD: The detection of molybdenum cofactor deficiency: clinical symptomatology and urinary metabolite profile. J Inherit Metab Dis. 1994;17(1):142-5.
pubmed_id:8051926
[3]:
reference_text:Zaki MS, Selim L, El-Bassyouni HT, Issa MY, Mahmoud I, Ismail S, Girgis M, Sadek AA, Gleeson JG, Abdel Hamid MS: Molybdenum cofactor and isolated sulphite oxidase deficiencies: Clinical and molecular spectrum among Egyptian patients. Eur J Paediatr Neurol. 2016 Sep;20(5):714-22. doi: 10.1016/j.ejpn.2016.05.011. Epub 2016 May 30.
pubmed_id:27289259
[4]:
reference_text:Sass JO, Kishikawa M, Puttinger R, Reiss J, Erwa W, Shimizu A, Sperl W: Hypohomocysteinaemia and highly increased proportion of S-sulfonated plasma transthyretin in molybdenum cofactor deficiency. J Inherit Metab Dis. 2003;26(1):80-2.
pubmed_id:12872846
[5]:
reference_text:MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de)
pubmed_id:
3:
name:Beta-mercaptolactate-cysteine Disulfiduria
omim_id:249650
[1]:
reference_text:Hannestad U, Martensson J, Sjodahl R, Sorbo B: 3-mercaptolactate cysteine disulfiduria: biochemical studies on affected and unaffected members of a family. Biochem Med. 1981 Aug;26(1):106-14.
pubmed_id:6945862
综合参考
Serikova, E. A.; Racheva, I. V. Method for producing sodium thiosulfate. U.S.S.R. (1986), CODEN: URXXAF SU 1279954 A1 19861230 Patent written in Russian.
一般参考
1:
protein_accession:HMDBP00781
name:3-mercaptopyruvate sulfurtransferase
uniprot_id:P25325
gene_name:MPST
protein_type:Enzyme
2:
protein_accession:HMDBP01045
name:Uridine 5'-monophosphate synthase
uniprot_id:P11172
gene_name:UMPS
protein_type:Enzyme
3:
protein_accession:HMDBP01056
name:Thiosulfate sulfurtransferase
uniprot_id:Q16762
gene_name:TST
protein_type:Unknown
4:
protein_accession:HMDBP09168
name:Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1
uniprot_id:Q8NFU3
gene_name:TSTD1
protein_type:Enzyme
蛋白质结合
1:
reference_text:Willis CL, Cummings JH, Neale G, Gibson GR: Nutritional aspects of dissimilatory sulfate reduction in the human large intestine. Curr Microbiol. 1997 Nov;35(5):294-8.
pubmed_id:9462959
2:
reference_text:Chatterjee BD, De PK, Sen T: Sucrose teepol tellurite agar: a new selective indicator medium for isolation of Vibrio species. J Infect Dis. 1977 Apr;135(4):654-8.
pubmed_id:856920
3:
reference_text:Rikimaru T, Kondo M, Kajimura K, Hashimoto K, Oyamada K, Sagawa K, Tanoue S, Oizumi K: Bactericidal activities of commonly used antiseptics against multidrug-resistant mycobacterium tuberculosis. Dermatology. 2002;204 Suppl 1:15-20.
pubmed_id:12011515
4:
reference_text:Maddocks JL, MacLachlan J: Application of new fluorescent thiol reagent to diagnosis of homocystinuria. Lancet. 1991 Oct 26;338(8774):1043-4.
pubmed_id:1681358
5:
reference_text:Ivankovich AD, Braverman B, Stephens TS, Shulman M, Heyman HJ: Sodium thiosulfate disposition in humans: relation to sodium nitroprusside toxicity. Anesthesiology. 1983 Jan;58(1):11-7.
pubmed_id:6600205
6:
reference_text:Kage S, Nagata T, Kudo K: Determination of thiosulfate in body fluids by GC and GC/MS. J Anal Toxicol. 1991 May-Jun;15(3):148-50.
pubmed_id:1943059
7:
reference_text:Rikimaru T, Kondo M, Kondo S, Oizumi K: Bactericidal activities of povidone-iodine against Mycobacterium. Dermatology. 1997;195 Suppl 2:104-6.
pubmed_id:9403266
8:
reference_text:Zewert TE, Pliquett UF, Vanbever R, Langer R, Weaver JC: Creation of transdermal pathways for macromolecule transport by skin electroporation and a low toxicity, pathway-enlarging molecule. Bioelectrochem Bioenerg. 1999 Oct;49(1):11-20.
pubmed_id:10619443
9:
reference_text:Freyberg RH, Block WD, Levey S: METABOLISM, TOXICITY AND MANNER OF ACTION OF GOLD COMPOUNDS USED IN THE TREATMENT OF ARTHRITIS. I. HUMAN PLASMA AND SYNOVIAL FLUID CONCENTRATION AND URINARY EXCRETION OF GOLD DURING AND FOLLOWING TREATMENT WITH GOLD SODIUM THIOMALATE, GOLD SODIUM THIOSULFATE, AND COLLOIDAL GOLD SULFIDE. J Clin Invest. 1941 Jul;20(4):401-12.
pubmed_id:16694848
10:
reference_text:Westerlund J, Pudek M, Schreiber WE: A rapid and accurate spectrofluorometric method for quantification and screening of urinary porphyrins. Clin Chem. 1988 Feb;34(2):345-51.
pubmed_id:3342508
11:
reference_text:Yatzidis H: Gestational urinary hyperthiosulfaturia protects hypercalciuric normal pregnant women from nephrolithiasis. Int Urol Nephrol. 2004;36(3):445-9.
pubmed_id:15783122
12:
reference_text:Rennels MB, Levine MM, Daya V, Angle P, Young C: Selective vs. nonselective media and direct plating vs. enrichment technique in isolation of Vibrio cholerae: recommendations for clinical laboratories. J Infect Dis. 1980 Sep;142(3):328-31.
pubmed_id:7003031