人类代谢组数据库

版本

5.0

创建日期

2005-11-16 15:48:42 UTC

更新日期

2021-09-14 15:45:01 UTC

登录号

HMDB0000247

地位

quantified

二级访问

HMDB00247

名称

Sorbitol

描述

Sorbitol is a polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures. It is also used in many manufacturing processes, as a pharmaceutical aid, and in several research applications. Ascorbic acid fermentation; in solution form for moisture-conditioning of cosmetic creams and lotions, toothpaste, tobacco, gelatin; bodying agent for paper, textiles, and liquid pharmaceuticals; softener for candy; sugar crystallization inhibitor; surfactants; urethane resins and rigid foams; plasticizer, stabilizer for vinyl resins; food additive (sweetener, humectant, emulsifier, thickener, anticaking agent); dietary supplement. (Hawley's Condensed Chemical Dictionary) Biological Source: Occurs widely in plants ranging from algae to the higher orders. Fruits of the plant family Rosaceae, which include apples, pears, cherries, apricots, contain appreciable amounts. Rich sources are the fruits of the Sorbus and Crataegus species Use/Importance: Used for manufacturing of sorbose, propylene glycol, ascorbic acid, resins, plasticizers and as antifreeze mixtures with glycerol or glycol. Tablet diluent, sweetening agent and humectant, other food uses. Sorbitol is used in photometric determination of Ru(VI) and Ru(VIII); in acid-base titration of borate (Dictionary of Organic Compounds).

同义词

1:(-)-Sorbitol

2:(2R,3R,4R,5S)-Hexane-1,2,3,4,5,6-hexol

3:D-(-)-Sorbitol

4:D-Sorbit

5:D-SORBITOL

6:e 420

7:e-420

8:e420

9:g-Ol

10:GLC-Ol

11:L-Gulitol

12:D-Glucitol

13:Sorbitol 3% in plastic container

14:D-Sorbol

15:Diakarmon

16:Esasorb

17:Foodol D 70

18:Glucarine

19:Glucitol

20:Karion

21:Karion instant

22:Kyowa powder 50m

23:Multitol

24:Neosorb

25:Neosorb 20/60dC

26:Neosorb 70/02

27:Neosorb 70/70

28:Neosorb p 20/60

29:Neosorb p 60

30:Neosorb p 60W

31:Nivitin

32:Resulax

33:Sionit

34:Sionit K

35:Sionite

36:Sionon

37:Siosan

38:Sorbex m

39:Sorbex R

40:Sorbex RP

41:Sorbex S

42:Sorbex X

43:Sorbilande

44:Sorbilax

45:Sorbit

46:Sorbit D 70

47:Sorbit D-powder

48:Sorbit DP

49:Sorbit DP 50

50:Sorbit kyowa powder 50m

51:Sorbit L 70

52:Sorbit S

53:Sorbit T 70

54:Sorbit W 70

55:Sorbit W-powder

56:Sorbit W-powder 50

57:Sorbit WP

58:Sorbite

59:Sorbitol F

60:Sorbitol FK

61:Sorbitol FP

62:Sorbitol S

63:Sorbitol syrup C

64:Sorbitur

65:Sorbo

66:Sorbogem 712

67:Sorbol

68:Sorbostyl

69:Medefield brand OF sorbitol

70:Sorbitol pfizer brand

71:Yal

72:Klysma sorbit

73:Medevac

74:Trommsdorff brand OF sorbitol

75:Baxter brand OF sorbitol

76:Pfizer brand OF sorbitol

化学式

C6H14O6

平均分子量

182.1718

等位分子量

182.07903818

化学名称

(2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol

传统名称

D-sorbitol

CAS 登记号

50-70-4

代谢物结构字符串

OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

inchi标识符

InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1

印记键

FBPFZTCFMRRESA-JGWLITMVSA-N

分类学

description: belongs to the class of organic compounds known as sugar alcohols. These are hydrogenated forms of carbohydrate in which the carbonyl group (aldehyde or ketone, reducing sugar) has been reduced to a primary or secondary hydroxyl group.

description:Sugar alcohols

kingdom:Organic compounds

super_class:Organic oxygen compounds

class:Organooxygen compounds

sub_class:Carbohydrates and carbohydrate conjugates

molecular_framework:Aliphatic acyclic compounds

1:Hydrocarbon derivatives

2:Monosaccharides

3:Polyols

4:Primary alcohols

5:Secondary alcohols

6:Alcohol

7:Aliphatic acyclic compound

8:Hydrocarbon derivative

9:Monosaccharide

10:Polyol

11:Primary alcohol

12:Secondary alcohol

13:Sugar alcohol

14:glucitol

本体论

term:Physiological effect

definition:The effect on an organism physiology, resulting from its exposure to a chemical.

parent_id:

level:1

type:parent

term:Health effect

definition:A health condition or observation associated with a stimuli or with a biological activity of a chemical.

parent_id:7693

*level:2

type:parent

term:Health condition

definition:A health effect that consists on short or long-term disease, condition, disorder, syndrome or constant abnormality.

parent_id:7694

**level:3

type:parent

term:Uremia

definition:A disorder characterized by accummulation of solutes in the blood of people with chronic kidney disease. (do).

parent_id:7695

***level:4

type:child

synonym:Uraemia

term:Disposition

definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.

parent_id:

level:1

type:parent

term:Route of exposure

definition:A mean by which a chemical agent comes in contact with an organism, either under intended or unintended circumstances.

parent_id:7724

*level:2

type:parent

term:Enteral

definition:Chemical exposure via the alimentary canal (mouth to anus).

parent_id:7743

**level:3

type:parent

term:Ingestion

definition:Chemical exposure facilitated by entry through the mouth.

parent_id:7744

***level:4

type:child

synonym:Digestion

term:Source

definition:Natural or synthetic origin of a chemical.

parent_id:7724

*level:2

type:parent

term:Endogenous

definition:

parent_id:7735

**level:3

type:child

term:Food

definition:

parent_id:7735

**level:3

type:child

term:Biological

definition:A living organism (species or a higher taxonomy rank), in which a chemical can be found.

parent_id:7735

**level:3

type:parent

term:Animal

definition:A living organism belonging to the kingdom animalia. it feeds on organic matter, typically having specialized sense organs and nervous system and able to respond rapidly to stimuli.

parent_id:7736

***level:4

type:child

synonym:Fauna

term:Plant

definition:A living organism belonging to the kingdom plantea. typically, it grows in a permanent site, absorbs water and inorganic substances through its roots, and synthesizes nutrients in its leaves by photosynthesis using the green pigment chlorophyll. examples incude trees, shrubs, herbs, grasses, ferns, and mosses.

parent_id:7736

***level:4

type:parent

synonym:Flora

term:Biological location

definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.

parent_id:7724

*level:2

type:parent

term:Organ and components

definition:An anatomical organizational level including multiple tissues or substructures, which enables a common biological function.

parent_id:7725

**level:3

type:parent

term:Bladder

definition:The distensible sac-like organ that functions as a reservoir of urine, collecting from the kidneys and eliminating via the urethra. (nci).

parent_id:7727

***level:4

type:child

term:Prostate

definition:The male reproductive accessory gland that produces prostatic fluid and is located adjacent to or around the urethra distal to the urinary bladder in mammals. (nci).

parent_id:7727

***level:4

type:child

synonym:Prostate gland

term:Kidney

definition:The organs of the urinary tract located in the retroperitoneal cavity adjacent to the spine and composed of the renal cortex and the renal medulla. (nci).

parent_id:7727

***level:4

type:child

synonym:Kidneys

term:Liver

definition:An abdominal organ that has variable lobation which are composed mainly of hepatic lobules. (nci).

parent_id:7727

***level:4

type:child

term:Tissue and substructures

definition:An anatomical organizational level including multiple cells yet not comprising a complete organ .

parent_id:7725

**level:3

type:parent

term:Placenta

definition:An organ present in some vertebrates during embryonic gestation that surrounds the fetus and provides it with nutrients and oxygen, facilitates gas and waste exchange between the fetus and mother, and provides parasitic cloaking from the mother's immune system by excretion of neurokinin b. (nci).

parent_id:7729

***level:4

type:child

term:Adipose tissue

definition:A specialized form of connective tissue consisting primarily of adipocytes (fat cells), surrounded by a meshwork of collagen fibers. (NCI)

parent_id:7729

***level:4

type:child

synonym:Fat tissue

synonym:Body fat

synonym:Adipose

term:Biofluid and excreta

definition:A liquid, semi-solid or solid material originating in the body.

parent_id:7725

**level:3

type:parent

term:Feces

definition:The material discharged from the bowel during defecation. It consists of undigested food, intestinal mucus, epithelial cells, and bacteria.

parent_id:7731

***level:4

type:child

synonym:Fecal

synonym:Stool

synonym:Faecal

synonym:Faeces

term:Saliva

definition:The watery fluid in the mouth made by the salivary glands. saliva moistens food to help digestion and it helps protect the mouth against infections. (nci).

parent_id:7731

***level:4

type:child

term:Blood

definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.

parent_id:7731

***level:4

type:child

term:Urine

definition:Excretion in liquid state processed by the kidney.

parent_id:7731

***level:4

type:child

term:Cerebrospinal fluid

definition:The fluid that is contained within the brain ventricles, the subarachnoid space and the central canal of the spinal cord. (nci).

parent_id:7731

***level:4

type:child

synonym:Csf

term:Cell and elements

definition:An anatomical organizational level comprising of a single cell (or a fragment in some exceptions). a cell is defined by its type or function. it is the smallest unit of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid.

parent_id:7725

**level:3

type:parent

term:Extracellular

definition:The space external to the outermost structure of a cell.

parent_id:7732

***level:4

type:child

synonym:Extracellular region

term:Element

definition:

parent_id:7732

***level:4

type:parent

term:Cell

definition:

parent_id:7732

***level:4

type:parent

term:Subcellular

definition:An anatomical organizational level including a component within a biological cell .

parent_id:7725

**level:3

type:parent

term:Membrane

definition:

parent_id:7730

***level:4

type:child

term:Cell membrane

definition:A cellular compartment that separates a cellВ interiorВ from its exterior.

parent_id:7730

***level:4

type:child

synonym:Cellular membrane

term:Process

definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.

parent_id:

level:1

type:parent

term:Naturally occurring process

definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.

parent_id:7659

*level:2

type:parent

term:Biological process

definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.

parent_id:7660

**level:3

type:parent

term:Cellular process

definition:A biological process occurring within a cell or its surroundings.

parent_id:7661

***level:4

type:parent

term:Biochemical pathway

definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.

parent_id:7661

***level:4

type:parent

term:Role

definition:The purpose or function assumed by a chemical, either naturally or as intended by humans .

parent_id:

level:1

type:parent

term:Biological role

definition:The biological function of a chemical. the biological role answers the question how a chemical is involved in molecular processes in an organism. this can include biochemical effects of non-endogenous chemicals, which are also assigned an industrial application such as pharmaceuticals. the biological role is limited to cellular levls, and will not include role at system process level, such as a chemical which has a role in a disease.

parent_id:7671

*level:2

type:parent

term:Membrane stabilizer

definition:A chemical substance that supports the formation and maintenance of a structurally-sound and functioning cell or organelle membrane. Phospholipids form a bilayer and maintain the stability of the membrane structure together with proteins, and other lipids (i.e. cholesterol) which further strengthen it and decrease its permeability.

parent_id:7672

**level:3

type:child

synonym:Membrane stability agent

synonym:Membrane integrity agent

term:Energy source

definition:

parent_id:7672

**level:3

type:child

term:Energy storage

definition:A chemical substance which can be utilized for production of energy in the organism.

parent_id:7672

**level:3

type:child

term:Industrial application

definition:The assumed function of a chemical utilized by human.

parent_id:7671

*level:2

type:parent

term:Surfactant

definition:A chemical substance that has the ability to lower the surface tension of water or to reduce the interfacial tension between two immiscible substances. in the cspa consumer product ingredients dictionary, surfactants are classified on the basis of their ionic characteristics, as amphoteric, anionic, cationic, or nonionic; and functions, which are subdivided into the following major groups: surfactant - cleaning agent, surfactant - conditioning agent, surfactant - emulsifying agent, surfactant - foam booster , surfactant hydrotrop , surfactant - solubility agent, surfactant - suspending agent.

parent_id:7678

**level:3

type:child

synonym:Surface-active agent

term:Emulsifier

definition:Substances that promote the formation and stability of a suspension of fine particles of a liquid in another liquid.

parent_id:7678

**level:3

type:child

term:Pharmaceutical industry

definition:A pharmacologic activity for which a chemical substance is utilized owing to its biological role.

parent_id:7678

**level:3

type:parent

term:Pharmaceutical

definition:

parent_id:7679

***level:4

type:child

状态

Liquid

实验性质

kind:water_solubility

value:2750.0 mg/mL

source:

kind:logp

value:-2.20

source:SANGSTER (1994)

kind:melting_point

value:11 °C

source:

预测性质

kind:logp

value:-2.68

source:ALOGPS

kind:logs

value:0.10

source:ALOGPS

kind:solubility

value:229 g/L

source:ALOGPS

kind:logp

value:-3.7

source:ChemAxon

kind:pka_strongest_acidic

value:12.59

source:ChemAxon

kind:pka_strongest_basic

value:-3

source:ChemAxon

kind:iupac

value:(2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol

source:ChemAxon

kind:average_mass

value:182.1718

source:ChemAxon

kind:mono_mass

value:182.07903818

source:ChemAxon

10:

kind:smiles

value:OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

source:ChemAxon

11:

kind:formula

value:C6H14O6

source:ChemAxon

12:

kind:inchi

value:InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1

source:ChemAxon

13:

kind:inchikey

value:FBPFZTCFMRRESA-JGWLITMVSA-N

source:ChemAxon

14:

kind:polar_surface_area

value:121.38

source:ChemAxon

15:

kind:refractivity

value:38.4

source:ChemAxon

16:

kind:polarizability

value:17.12

source:ChemAxon

17:

kind:rotatable_bond_count

value:5

source:ChemAxon

18:

kind:acceptor_count

value:6

source:ChemAxon

19:

kind:donor_count

value:6

source:ChemAxon

20:

kind:physiological_charge

value:0

source:ChemAxon

21:

kind:formal_charge

value:0

source:ChemAxon

22:

kind:number_of_rings

value:0

source:ChemAxon

23:

kind:bioavailability

value:Yes

source:ChemAxon

24:

kind:rule_of_five

value:No

source:ChemAxon

25:

kind:ghose_filter

value:No

source:ChemAxon

26:

kind:veber_rule

value:No

source:ChemAxon

27:

kind:mddr_like_rule

value:No

source:ChemAxon

type:Specdb::NmrTwoD

spectrum_id:1236

type:Specdb::CMs

spectrum_id:486

type:Specdb::CMs

spectrum_id:1651

type:Specdb::CMs

spectrum_id:2338

type:Specdb::CMs

spectrum_id:30531

type:Specdb::CMs

spectrum_id:31102

type:Specdb::CMs

spectrum_id:32318

type:Specdb::CMs

spectrum_id:37385

type:Specdb::CMs

spectrum_id:167112

10:

type:Specdb::NmrOneD

spectrum_id:1216

11:

type:Specdb::NmrOneD

spectrum_id:1273

12:

type:Specdb::NmrOneD

spectrum_id:4929

13:

type:Specdb::NmrOneD

spectrum_id:6252

14:

type:Specdb::NmrOneD

spectrum_id:6253

15:

type:Specdb::NmrOneD

spectrum_id:6254

16:

type:Specdb::NmrOneD

spectrum_id:6255

17:

type:Specdb::NmrOneD

spectrum_id:6256

18:

type:Specdb::NmrOneD

spectrum_id:6257

19:

type:Specdb::NmrOneD

spectrum_id:6258

20:

type:Specdb::NmrOneD

spectrum_id:6259

21:

type:Specdb::NmrOneD

spectrum_id:6260

22:

type:Specdb::NmrOneD

spectrum_id:6261

23:

type:Specdb::NmrOneD

spectrum_id:6262

24:

type:Specdb::NmrOneD

spectrum_id:6263

25:

type:Specdb::NmrOneD

spectrum_id:6264

26:

type:Specdb::NmrOneD

spectrum_id:6265

27:

type:Specdb::NmrOneD

spectrum_id:6266

28:

type:Specdb::NmrOneD

spectrum_id:6267

29:

type:Specdb::NmrOneD

spectrum_id:6268

30:

type:Specdb::NmrOneD

spectrum_id:6269

31:

type:Specdb::NmrOneD

spectrum_id:6270

32:

type:Specdb::NmrOneD

spectrum_id:6271

33:

type:Specdb::NmrOneD

spectrum_id:166528

34:

type:Specdb::MsMs

spectrum_id:421

35:

type:Specdb::MsMs

spectrum_id:422

36:

type:Specdb::MsMs

spectrum_id:423

37:

type:Specdb::MsMs

spectrum_id:177957

38:

type:Specdb::MsMs

spectrum_id:177958

39:

type:Specdb::MsMs

spectrum_id:177959

40:

type:Specdb::MsMs

spectrum_id:180270

41:

type:Specdb::MsMs

spectrum_id:180271

42:

type:Specdb::MsMs

spectrum_id:180272

43:

type:Specdb::MsMs

spectrum_id:439783

44:

type:Specdb::MsMs

spectrum_id:439784

45:

type:Specdb::MsMs

spectrum_id:447483

46:

type:Specdb::MsMs

spectrum_id:449938

47:

type:Specdb::MsMs

spectrum_id:449939

48:

type:Specdb::MsMs

spectrum_id:449940

49:

type:Specdb::MsMs

spectrum_id:449941

50:

type:Specdb::MsMs

spectrum_id:449942

51:

type:Specdb::MsMs

spectrum_id:449943

52:

type:Specdb::MsMs

spectrum_id:449944

53:

type:Specdb::MsMs

spectrum_id:449945

54:

type:Specdb::MsMs

spectrum_id:2236749

55:

type:Specdb::MsMs

spectrum_id:2239864

56:

type:Specdb::MsMs

spectrum_id:2241833

57:

type:Specdb::MsMs

spectrum_id:2777195

58:

type:Specdb::MsMs

spectrum_id:2777196

光谱

生物学性质

cellular:(1):Extracellular

cellular:(2):Membrane

biospecimen:(1):Blood

biospecimen:(2):Cerebrospinal Fluid (CSF)

biospecimen:(3):Feces

biospecimen:(4):Saliva

biospecimen:(5):Urine

tissue:(1):Adipose Tissue

tissue:(2):Adrenal Medulla

tissue:(3):Bladder

tissue:(4):Erythrocyte

tissue:(5):Eye Lens

tissue:(6):Fibroblasts

tissue:(7):Kidney

tissue:(8):Liver

tissue:(9):Neuron

tissue:(10):Placenta

tissue:(11):Platelet

tissue:(12):Prostate

tissue:(13):Retina

[1]:

name:Fructose and mannose metabolism

smpdb_id:

kegg_map_id:map00051

[2]:

name:Fructose intolerance, hereditary

smpdb_id:SMP00725

kegg_map_id:

[3]:

name:Fructosuria

smpdb_id:SMP00561

kegg_map_id:

[4]:

name:Galactose Metabolism

smpdb_id:SMP00043

kegg_map_id:map00052

[5]:

name:Galactosemia

smpdb_id:SMP00182

kegg_map_id:

正常浓度

biospecimen:Blood

concentration_value:1.09 +/- 0.37

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

biospecimen:Blood

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

biospecimen:Blood

concentration_value:<2.198

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

biospecimen:Blood

concentration_value:13.0 (4.0-24.0)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:13.0 (9.49-16.5)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:19.43 +/- 5.65

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:19.4 +/- 5.6

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:15.6 +/- 1.9

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:17.2 +/- 4.6

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

10:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

11:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

12:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

13:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Children (6 - 18 years old)

subject_sex:Not Specified

subject_condition:Normal

14:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

15:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

16:

biospecimen:Saliva

concentration_value:196.17 +/- 346.21

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

17:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

18:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

19:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

20:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

21:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

22:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

23:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

24:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

25:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

26:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

27:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

28:

biospecimen:Saliva

concentration_value:<1.00

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

29:

biospecimen:Urine

concentration_value:3.9 (1.9-5.1)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

30:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

31:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

32:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

33:

biospecimen:Urine

concentration_value:9.9 (2.5-18.7)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

34:

biospecimen:Urine

concentration_value:3.5 +/- 2.24

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

35:

biospecimen:Urine

concentration_value:46.064 +/- 38.805

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

36:

biospecimen:Urine

concentration_value:9.74 +/- 10.36

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

异常浓度

biospecimen:Blood

concentration_value:17.0330 +/- 11.538

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Uremia

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:23.3 +/- 3.3

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Alzheimer's disease

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:22.89 +/- 3.34

concentration_units:uM

patient_age:Not Specified

patient_sex:Not Specified

patient_information:Alzheimer's disease

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Crohns disease

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Ulcerative colitis

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Unclassified IBD

biospecimen:Urine

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Bladder cancer

biospecimen:Urine

concentration_value:52.238

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Eosinophilic esophagitis

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name:Colorectal cancer

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reference_text:Ni Y, Xie G, Jia W: Metabonomics of human colorectal cancer: new approaches for early diagnosis and biomarker discovery. J Proteome Res. 2014 Sep 5;13(9):3857-70. doi: 10.1021/pr500443c. Epub 2014 Aug 14.

pubmed_id:25105552

[9]:

reference_text:Ikeda A, Nishiumi S, Shinohara M, Yoshie T, Hatano N, Okuno T, Bamba T, Fukusaki E, Takenawa T, Azuma T, Yoshida M: Serum metabolomics as a novel diagnostic approach for gastrointestinal cancer. Biomed Chromatogr. 2012 May;26(5):548-58. doi: 10.1002/bmc.1671. Epub 2011 Jul 20.

pubmed_id:21773981

[10]:

reference_text:Goedert JJ, Sampson JN, Moore SC, Xiao Q, Xiong X, Hayes RB, Ahn J, Shi J, Sinha R: Fecal metabolomics: assay performance and association with colorectal cancer. Carcinogenesis. 2014 Sep;35(9):2089-96. doi: 10.1093/carcin/bgu131. Epub 2014 Jul 18.

pubmed_id:25037050

[11]:

reference_text:Sinha R, Ahn J, Sampson JN, Shi J, Yu G, Xiong X, Hayes RB, Goedert JJ: Fecal Microbiota, Fecal Metabolome, and Colorectal Cancer Interrelations. PLoS One. 2016 Mar 25;11(3):e0152126. doi: 10.1371/journal.pone.0152126. eCollection 2016.

pubmed_id:27015276

[12]:

reference_text:Lin Y, Ma C, Liu C, Wang Z, Yang J, Liu X, Shen Z, Wu R: NMR-based fecal metabolomics fingerprinting as predictors of earlier diagnosis in patients with colorectal cancer. Oncotarget. 2016 May 17;7(20):29454-64. doi: 10.18632/oncotarget.8762.

pubmed_id:27107423

[13]:

reference_text:Brown DG, Rao S, Weir TL, O'Malia J, Bazan M, Brown RJ, Ryan EP: Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool. Cancer Metab. 2016 Jun 6;4:11. doi: 10.1186/s40170-016-0151-y. eCollection 2016.

pubmed_id:27275383

[14]:

reference_text:Wang X, Wang J, Rao B, Deng L: Gut flora profiling and fecal metabolite composition of colorectal cancer patients and healthy individuals. Exp Ther Med. 2017 Jun;13(6):2848-2854. doi: 10.3892/etm.2017.4367. Epub 2017 Apr 20.

pubmed_id:28587349

[15]:

reference_text:Silke Matysik, Caroline Ivanne Le Roy, Gerhard Liebisch, Sandrine Paule Claus. Metabolomics of fecal samples: A practical consideration. Trends in Food Science & Technology. Vol. 57, Part B, Nov. 2016, p.244-255: http://www.sciencedirect.com/science/article/pii/S0924224416301984

name:Eosinophilic esophagitis

omim_id:610247

[1]:

reference_text:Mordechai, Hien, and David S. Wishart

pubmed_id:

KEGG数据库编号

C00794

DrugBank数据库编号

DB01638

foodb数据库编号

FDB011676

ChemSpider数据库编号

5576

公共化学化合物编号

5780

PDB数据库编号

生物利益的化学实体数据库编号

17924

knapsack数据库编号

C00001173

维基百科编号

Sorbitol

代谢途径的数据库编号

SORBITOL

苯酚资源管理器化合物数据库编号

比格数据库编号

梅林编号

虚拟机身份证编号

SBT_D

fbonto数据库编号

综合参考

Liu, Haichao; Luo, Chen. Method for manufacturing sorbitol and mannitol with cellulose. Faming Zhuanli Shenqing Gongkai Shuomingshu (2007), 8pp.

一般参考

protein_accession:HMDBP00088

name:Aldose reductase

uniprot_id:P15121

gene_name:AKR1B1

protein_type:Unknown

protein_accession:HMDBP00210

name:Glucokinase

uniprot_id:P35557

gene_name:GCK

protein_type:Enzyme

protein_accession:HMDBP00212

name:Hexokinase-3

uniprot_id:P52790

gene_name:HK3

protein_type:Enzyme

protein_accession:HMDBP00213

name:Hexokinase-2

uniprot_id:P52789

gene_name:HK2

protein_type:Enzyme

protein_accession:HMDBP00506

name:Sorbitol dehydrogenase

uniprot_id:Q00796

gene_name:SORD

protein_type:Unknown

protein_accession:HMDBP00723

name:Alpha-galactosidase A

uniprot_id:P06280

gene_name:GLA

protein_type:Enzyme

protein_accession:HMDBP01980

name:Glycophorin-B

uniprot_id:P06028

gene_name:GYPB

protein_type:Enzyme

protein_accession:HMDBP11606

name:Aldo-keto reductase family 1 member B10

uniprot_id:O60218

gene_name:AKR1B10

protein_type:Unknown

蛋白质结合

reference_text:Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762.

pubmed_id:19212411

reference_text:Airey CM, Price DE, Kemp JV, Perkins CM, Wales JK: The effect of aldose reductase inhibition on erythrocyte polyols and galactitol accumulation in diabetic patients. Diabet Med. 1989 Dec;6(9):804-8.

pubmed_id:2533041

reference_text:Shetty HU, Holloway HW, Rapoport SI: Capillary gas chromatography combined with ion trap detection for quantitative profiling of polyols in cerebrospinal fluid and plasma. Anal Biochem. 1995 Jan 1;224(1):279-85.

pubmed_id:7710082

reference_text:Sundkvist G, Dahlin LB, Nilsson H, Eriksson KF, Lindgarde F, Rosen I, Lattimer SA, Sima AA, Sullivan K, Greene DA: Sorbitol and myo-inositol levels and morphology of sural nerve in relation to peripheral nerve function and clinical neuropathy in men with diabetic, impaired, and normal glucose tolerance. Diabet Med. 2000 Apr;17(4):259-68.

pubmed_id:10821291

reference_text:Morenkova SA: [Comparative analysis of dependence of saliva sorbitol and fructosamine levels on blood glucose level in patients with diabetes]. Biomed Khim. 2004;50(6):612-4.

pubmed_id:15707277

reference_text:Bareford D, Jennings PE, Stone PC, Baar S, Barnett AH, Stuart J: Effects of hyperglycaemia and sorbitol accumulation on erythrocyte deformability in diabetes mellitus. J Clin Pathol. 1986 Jul;39(7):722-7.

pubmed_id:3090107

reference_text:Ciuchi E, Odetti P, Prando R: Relationship between glutathione and sorbitol concentrations in erythrocytes from diabetic patients. Metabolism. 1996 May;45(5):611-3.

pubmed_id:8622605

reference_text:Kwang-Hyok S, Ui-Nam P, Sarkar C, Bhadra R: A sensitive assay of red blood cell sorbitol level by high performance liquid chromatography: potential for diagnostic evaluation of diabetes. Clin Chim Acta. 2005 Apr;354(1-2):41-7. Epub 2005 Jan 18.

pubmed_id:15748598

reference_text:Nau R: Osmotherapy for elevated intracranial pressure: a critical reappraisal. Clin Pharmacokinet. 2000 Jan;38(1):23-40.

pubmed_id:10668857

10:

reference_text:Belanger DR, Tierney MG, Dickinson G: Effect of sodium polystyrene sulfonate on lithium bioavailability. Ann Emerg Med. 1992 Nov;21(11):1312-5.

pubmed_id:1416324

11:

reference_text:Ciuchi E, Odetti P, Prando R: The effect of acute glutathione treatment on sorbitol level in erythrocytes from diabetic patients. Diabetes Metab. 1997 Feb;23(1):58-60.

pubmed_id:9059767

12:

reference_text:Shinohara R, Ohta Y, Yamauchi M, Ishiguro I: Improved fluorometric enzymatic sorbitol assay in human blood. Clin Chim Acta. 1998 May 25;273(2):171-84.

pubmed_id:9657347

13:

reference_text:Peterson MJ, Page MG, Just LJ, Aldinger CE, Malone JI: Applicability of red blood cell sorbitol measurements to monitor the clinical activity of sorbinil. Metabolism. 1986 Apr;35(4 Suppl 1):93-5.

pubmed_id:3515121

14:

reference_text:Vertommen J, Rillaerts E, Gysels M, De Leeuw I: Erythrocyte sorbitol content in diabetic patients: relation to metabolic control. Diabete Metab. 1987 Jun;13(3):182-6.

pubmed_id:3301442

15:

reference_text:Cunningham JJ, Mearkle PL, Brown RG: Vitamin C: an aldose reductase inhibitor that normalizes erythrocyte sorbitol in insulin-dependent diabetes mellitus. J Am Coll Nutr. 1994 Aug;13(4):344-50.

pubmed_id:7963139

16:

reference_text:Kamon N, Mabuchi H, Takeda R, Terashima H: Effects of aldose reductase inhibitor (ONO-2235) on human erythrocyte sorbitol concentrations in 75 g oral glucose tolerance tests. Horm Metab Res. 1991 May;23(5):226-9.

pubmed_id:1908433

17:

reference_text:Sizeland PC, Chambers ST, Lever M, Bason LM, Robson RA: Short-term response of nonurea organic osmolytes in human kidney to a water load and water deprivation. Am J Physiol. 1995 Feb;268(2 Pt 2):F227-33.

pubmed_id:7864160

18:

reference_text:van Griensven JM, Jusko WJ, Lemkes HH, Kroon R, Verhorst CJ, Chiang ST, Cohen AF: Tolrestat pharmacokinetic and pharmacodynamic effects on red blood cell sorbitol levels in normal volunteers and in patients with insulin-dependent diabetes. Clin Pharmacol Ther. 1995 Dec;58(6):631-40.

pubmed_id:8529328

19:

reference_text:Regenold WT, Kling MA, Hauser P: Elevated sorbitol concentration in the cerebrospinal fluid of patients with mood disorders. Psychoneuroendocrinology. 2000 Aug;25(6):593-606.

pubmed_id:10840171

20:

reference_text:Gehring H, Hornberger C, Dibbelt L, Dorges V, Eichenauer R, Schmucker P: Detecting and quantifying absorbed irrigation fluid by measuring mannitol and sorbitol concentrations in serum samples, and by ethanol monitoring. BJU Int. 2002 Feb;89(3):202-7.

pubmed_id:11856099

21:

reference_text:Burggraaf J, Schoemaker RC, Lentjes EG, Cohen AF: Sorbitol as a marker for drug-induced decreases of variable duration in liver blood flow in healthy volunteers. Eur J Pharm Sci. 2000 Dec;12(2):133-9.

pubmed_id:11102741

22:

reference_text:Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043.

pubmed_id:32033212

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名称
描述
同义词
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平均分子量
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化学名称
传统名称
CAS 登记号
代谢物结构字符串
inchi标识符
印记键
分类学
本体论
状态
实验性质
预测性质
光谱
生物学性质
正常浓度
异常浓度
疾病参考
KEGG数据库编号
DrugBank数据库编号
foodb数据库编号
ChemSpider数据库编号
公共化学化合物编号
PDB数据库编号
生物利益的化学实体数据库编号
knapsack数据库编号
维基百科编号
代谢途径的数据库编号
苯酚资源管理器化合物数据库编号
比格数据库编号
梅林编号
虚拟机身份证编号
fbonto数据库编号
综合参考
一般参考
蛋白质结合

目录