创建日期
2005-11-16 15:48:42 UTC
更新日期
2021-09-14 15:48:25 UTC
描述
Riboflavin or vitamin B2 is an easily absorbed, water-soluble micronutrient with a key role in maintaining human health. Like the other B vitamins, it supports energy production by aiding in the metabolizing of fats, carbohydrates, and proteins. Vitamin B2 is also required for red blood cell formation and respiration, antibody production, and for regulating human growth and reproduction. It is essential for healthy skin, nails, hair growth and general good health, including regulating thyroid activity. Riboflavin is found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. Riboflavin is yellow or orange-yellow in color and in addition to being used as a food coloring it is also used to fortify some foods. It can be found in baby foods, breakfast cereals, sauces, processed cheese, fruit drinks and vitamin-enriched milk products. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin adenine dinucleotide.
同义词
1:1-Deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)pentitol
2:6,7-Dimethyl-9-D-ribitylisoalloxazine
3:7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)benzo[g]pteridine-2,4(3H,10H)-dione
4:7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine
5:7,8-Dimethyl-10-ribitylisoalloxazine
6:e101
7:Lactoflavin
8:Riboflavina
9:RIBOFLAVINE
10:Riboflavinum
11:Vitamin b2
12:Vitamin g
13:Bisulase
14:(-)-Riboflavin
15:1-Deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10(2H)-yl)-D-ribitol
16:6,7-Dimethyl-9-ribitylisoalloxazine
17:7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)-benzo[g]pteridine-2,4(3H,10H)-dione
18:Beflavin
19:Beflavine
20:Benzo[g]pteridine riboflavin deriv.
21:e 101
22:Flavaxin
23:Flavin BB
24:Flaxain
25:FOOD Yellow 15
26:Hyre
27:Lactobene
28:Lactoflavine
29:Ribipca
30:Ribocrisina
31:Riboderm
32:Ribosyn
33:Ribotone
34:Ribovel
35:Russupteridine yellow III
36:San yellow b
37:Vitaflavine
38:Vitasan b2
39:Vitamin b 2
化学名称
7,8-dimethyl-10-[(2S,3S,4R)-2,3,4,5-tetrahydroxypentyl]-2H,3H,4H,10H-benzo[g]pteridine-2,4-dione
代谢物结构字符串
CC1=C(C)C=C2N(C[C@H](O)[C@H](O)[C@H](O)CO)C3=NC(=O)NC(=O)C3=NC2=C1
inchi标识符
InChI=1S/C17H20N4O6/c1-7-3-9-10(4-8(7)2)21(5-11(23)14(25)12(24)6-22)15-13(18-9)16(26)20-17(27)19-15/h3-4,11-12,14,22-25H,5-6H2,1-2H3,(H,20,26,27)/t11-,12+,14-/m0/s1
印记键
AUNGANRZJHBGPY-SCRDCRAPSA-N
分类学
description: belongs to the class of organic compounds known as flavins. Flavins are compounds containing a flavin (7,8-dimethyl-benzo[g]pteridine-2,4-dione) moiety, with a structure characterized by an isoalloaxzine tricyclic ring.
description:Flavins
kingdom:Organic compounds
super_class:Organoheterocyclic compounds
class:Pteridines and derivatives
sub_class:Alloxazines and isoalloxazines
molecular_framework:Aromatic heteropolycyclic compounds
1:Azacyclic compounds
2:Benzenoids
3:Heteroaromatic compounds
4:Hydrocarbon derivatives
5:Lactams
6:Organic oxides
7:Organonitrogen compounds
8:Organopnictogen compounds
9:Polyols
10:Primary alcohols
11:Pyrazines
12:Pyrimidones
13:Quinoxalines
14:Secondary alcohols
15:Vinylogous amides
16:Alcohol
17:Aromatic heteropolycyclic compound
18:Azacycle
19:Benzenoid
20:Diazanaphthalene
21:Flavin
22:Heteroaromatic compound
23:Hydrocarbon derivative
24:Lactam
25:Organic nitrogen compound
26:Organic oxide
27:Organic oxygen compound
28:Organonitrogen compound
29:Organooxygen compound
30:Organopnictogen compound
31:Polyol
32:Primary alcohol
33:Pyrazine
34:Pyrimidine
35:Pyrimidone
36:Quinoxaline
37:Secondary alcohol
38:Vinylogous amide
39:Water-soluble vitamins
40:flavin
本体论
term:Physiological effect
definition:The effect on an organism physiology, resulting from its exposure to a chemical.
parent_id:
level:1
type:parent
term:Health effect
definition:A health condition or observation associated with a stimuli or with a biological activity of a chemical.
parent_id:7693
*level:2
type:parent
term:Health condition
definition:A health effect that consists on short or long-term disease, condition, disorder, syndrome or constant abnormality.
parent_id:7694
**level:3
type:parent
term:Anorexia nervosa
definition:An eating disorder characterized by refusal to maintain a healthy body weight, and an obsessive fear of gaining weight due to a distorted self image. (do).
parent_id:7695
***level:4
type:child
synonym:Anorexia
term:Disposition
definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.
parent_id:
level:1
type:parent
term:Route of exposure
definition:A mean by which a chemical agent comes in contact with an organism, either under intended or unintended circumstances.
parent_id:7724
*level:2
type:parent
term:Enteral
definition:Chemical exposure via the alimentary canal (mouth to anus).
parent_id:7743
**level:3
type:parent
term:Gastrointestinal
definition:Chemical exposure by absorption through the stomach and intestines.
parent_id:7744
***level:4
type:child
synonym:Gi tract
term:Ingestion
definition:Chemical exposure facilitated by entry through the mouth.
parent_id:7744
***level:4
type:child
synonym:Digestion
term:Source
definition:Natural or synthetic origin of a chemical.
parent_id:7724
*level:2
type:parent
term:Food
definition:
parent_id:7735
**level:3
type:child
term:Synthetic
definition:A man-made product or sample in which a chemical can be found.
parent_id:7735
**level:3
type:parent
term:Personal care product
definition:
parent_id:7742
***level:4
type:child
synonym:Pcp
synonym:Toiletries
synonym:Toiletry
synonym:Personal hygiene
synonym:Beautification product
term:Biological
definition:A living organism (species or a higher taxonomy rank), in which a chemical can be found.
parent_id:7735
**level:3
type:parent
term:Animal
definition:A living organism belonging to the kingdom animalia. it feeds on organic matter, typically having specialized sense organs and nervous system and able to respond rapidly to stimuli.
parent_id:7736
***level:4
type:child
synonym:Fauna
term:Plant
definition:A living organism belonging to the kingdom plantea. typically, it grows in a permanent site, absorbs water and inorganic substances through its roots, and synthesizes nutrients in its leaves by photosynthesis using the green pigment chlorophyll. examples incude trees, shrubs, herbs, grasses, ferns, and mosses.
parent_id:7736
***level:4
type:parent
synonym:Flora
term:Biological location
definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.
parent_id:7724
*level:2
type:parent
term:Tissue and substructures
definition:An anatomical organizational level including multiple cells yet not comprising a complete organ .
parent_id:7725
**level:3
type:parent
term:Placenta
definition:An organ present in some vertebrates during embryonic gestation that surrounds the fetus and provides it with nutrients and oxygen, facilitates gas and waste exchange between the fetus and mother, and provides parasitic cloaking from the mother's immune system by excretion of neurokinin b. (nci).
parent_id:7729
***level:4
type:child
term:Subcellular
definition:An anatomical organizational level including a component within a biological cell .
parent_id:7725
**level:3
type:parent
term:Mitochondria
definition:
parent_id:7730
***level:4
type:child
term:Cytoplasm
definition:The portion of the cell contained within the plasma membrane but excluding the nucleus.
parent_id:7730
***level:4
type:child
synonym:Cytoplasma
term:Organ and components
definition:An anatomical organizational level including multiple tissues or substructures, which enables a common biological function.
parent_id:7725
**level:3
type:parent
term:Heart
definition:A hollow muscular organ which receives the blood from the veins and pumps it into the arteries. (nci).
parent_id:7727
***level:4
type:child
term:Prostate
definition:The male reproductive accessory gland that produces prostatic fluid and is located adjacent to or around the urethra distal to the urinary bladder in mammals. (nci).
parent_id:7727
***level:4
type:child
synonym:Prostate gland
term:Kidney
definition:The organs of the urinary tract located in the retroperitoneal cavity adjacent to the spine and composed of the renal cortex and the renal medulla. (nci).
parent_id:7727
***level:4
type:child
synonym:Kidneys
term:Liver
definition:An abdominal organ that has variable lobation which are composed mainly of hepatic lobules. (nci).
parent_id:7727
***level:4
type:child
term:Cell and elements
definition:An anatomical organizational level comprising of a single cell (or a fragment in some exceptions). a cell is defined by its type or function. it is the smallest unit of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid.
parent_id:7725
**level:3
type:parent
term:Extracellular
definition:The space external to the outermost structure of a cell.
parent_id:7732
***level:4
type:child
synonym:Extracellular region
term:Biofluid and excreta
definition:A liquid, semi-solid or solid material originating in the body.
parent_id:7725
**level:3
type:parent
term:Saliva
definition:The watery fluid in the mouth made by the salivary glands. saliva moistens food to help digestion and it helps protect the mouth against infections. (nci).
parent_id:7731
***level:4
type:child
term:Feces
definition:The material discharged from the bowel during defecation. It consists of undigested food, intestinal mucus, epithelial cells, and bacteria.
parent_id:7731
***level:4
type:child
synonym:Fecal
synonym:Stool
synonym:Faecal
synonym:Faeces
term:Urine
definition:Excretion in liquid state processed by the kidney.
parent_id:7731
***level:4
type:child
term:Blood
definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.
parent_id:7731
***level:4
type:child
term:Cerebrospinal fluid
definition:The fluid that is contained within the brain ventricles, the subarachnoid space and the central canal of the spinal cord. (nci).
parent_id:7731
***level:4
type:child
synonym:Csf
term:Process
definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.
parent_id:
level:1
type:parent
term:Naturally occurring process
definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.
parent_id:7659
*level:2
type:parent
term:Biological process
definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.
parent_id:7660
**level:3
type:parent
term:Biochemical pathway
definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.
parent_id:7661
***level:4
type:parent
term:Role
definition:The purpose or function assumed by a chemical, either naturally or as intended by humans .
parent_id:
level:1
type:parent
term:Industrial application
definition:The assumed function of a chemical utilized by human.
parent_id:7671
*level:2
type:parent
term:Drug
definition:A chemical substance or preparation that causes a physiological effect in the body upon exposure .
parent_id:7678
**level:3
type:child
term:Food and nutrition
definition:A chemical purpose related to manufacturing of food and nutrition products.
parent_id:7678
**level:3
type:child
term:Personal care products
definition:Cosmetics and personal hygene products in which a chemical was incorportaed during the manufacturing process.
parent_id:7678
**level:3
type:child
term:Pharmaceutical industry
definition:A pharmacologic activity for which a chemical substance is utilized owing to its biological role.
parent_id:7678
**level:3
type:parent
term:Pharmaceutical
definition:
parent_id:7679
***level:4
type:child
term:Biological role
definition:The biological function of a chemical. the biological role answers the question how a chemical is involved in molecular processes in an organism. this can include biochemical effects of non-endogenous chemicals, which are also assigned an industrial application such as pharmaceuticals. the biological role is limited to cellular levls, and will not include role at system process level, such as a chemical which has a role in a disease.
parent_id:7671
*level:2
type:parent
term:Essential vitamin
definition:
parent_id:7672
**level:3
type:child
实验性质
1:
kind:water_solubility
value:0.0847 mg/mL
source:
2:
kind:logp
value:-1.46
source:HANSCH,C ET AL. (1995)
3:
kind:melting_point
value:290 °C
source:
预测性质
1:
kind:logp
value:-1.05
source:ALOGPS
2:
kind:logs
value:-2.76
source:ALOGPS
3:
kind:solubility
value:0.66 g/L
source:ALOGPS
4:
kind:logp
value:-0.92
source:ChemAxon
5:
kind:pka_strongest_acidic
value:5.97
source:ChemAxon
6:
kind:pka_strongest_basic
value:-2.6
source:ChemAxon
7:
kind:iupac
value:7,8-dimethyl-10-[(2S,3S,4R)-2,3,4,5-tetrahydroxypentyl]-2H,3H,4H,10H-benzo[g]pteridine-2,4-dione
source:ChemAxon
8:
kind:average_mass
value:376.3639
source:ChemAxon
9:
kind:mono_mass
value:376.138284392
source:ChemAxon
10:
kind:smiles
value:CC1=C(C)C=C2N(C[C@H](O)[C@H](O)[C@H](O)CO)C3=NC(=O)NC(=O)C3=NC2=C1
source:ChemAxon
11:
kind:formula
value:C17H20N4O6
source:ChemAxon
12:
kind:inchi
value:InChI=1S/C17H20N4O6/c1-7-3-9-10(4-8(7)2)21(5-11(23)14(25)12(24)6-22)15-13(18-9)16(26)20-17(27)19-15/h3-4,11-12,14,22-25H,5-6H2,1-2H3,(H,20,26,27)/t11-,12+,14-/m0/s1
source:ChemAxon
13:
kind:inchikey
value:AUNGANRZJHBGPY-SCRDCRAPSA-N
source:ChemAxon
14:
kind:polar_surface_area
value:155.05
source:ChemAxon
15:
kind:refractivity
value:96.27
source:ChemAxon
16:
kind:polarizability
value:37.51
source:ChemAxon
17:
kind:rotatable_bond_count
value:5
source:ChemAxon
18:
kind:acceptor_count
value:9
source:ChemAxon
19:
kind:donor_count
value:5
source:ChemAxon
20:
kind:physiological_charge
value:-1
source:ChemAxon
21:
kind:formal_charge
value:0
source:ChemAxon
22:
kind:number_of_rings
value:3
source:ChemAxon
23:
kind:bioavailability
value:Yes
source:ChemAxon
24:
kind:rule_of_five
value:Yes
source:ChemAxon
25:
kind:ghose_filter
value:No
source:ChemAxon
26:
kind:veber_rule
value:No
source:ChemAxon
27:
kind:mddr_like_rule
value:No
source:ChemAxon
1:
type:Specdb::NmrTwoD
spectrum_id:1234
2:
type:Specdb::CMs
spectrum_id:10276
3:
type:Specdb::CMs
spectrum_id:29895
4:
type:Specdb::CMs
spectrum_id:37383
5:
type:Specdb::CMs
spectrum_id:99553
6:
type:Specdb::CMs
spectrum_id:148319
7:
type:Specdb::MsMs
spectrum_id:412
8:
type:Specdb::MsMs
spectrum_id:413
9:
type:Specdb::MsMs
spectrum_id:414
10:
type:Specdb::MsMs
spectrum_id:3736
11:
type:Specdb::MsMs
spectrum_id:3737
12:
type:Specdb::MsMs
spectrum_id:179583
13:
type:Specdb::MsMs
spectrum_id:179584
14:
type:Specdb::MsMs
spectrum_id:179585
15:
type:Specdb::MsMs
spectrum_id:181914
16:
type:Specdb::MsMs
spectrum_id:181915
17:
type:Specdb::MsMs
spectrum_id:181916
18:
type:Specdb::MsMs
spectrum_id:374336
19:
type:Specdb::MsMs
spectrum_id:439241
20:
type:Specdb::MsMs
spectrum_id:439535
21:
type:Specdb::MsMs
spectrum_id:439536
22:
type:Specdb::MsMs
spectrum_id:439733
23:
type:Specdb::MsMs
spectrum_id:448178
24:
type:Specdb::MsMs
spectrum_id:449588
25:
type:Specdb::MsMs
spectrum_id:449589
26:
type:Specdb::MsMs
spectrum_id:449590
27:
type:Specdb::MsMs
spectrum_id:449591
28:
type:Specdb::MsMs
spectrum_id:449592
29:
type:Specdb::MsMs
spectrum_id:449593
30:
type:Specdb::MsMs
spectrum_id:449827
31:
type:Specdb::MsMs
spectrum_id:449828
32:
type:Specdb::NmrOneD
spectrum_id:1268
33:
type:Specdb::NmrOneD
spectrum_id:143170
34:
type:Specdb::NmrOneD
spectrum_id:143171
35:
type:Specdb::NmrOneD
spectrum_id:143172
36:
type:Specdb::NmrOneD
spectrum_id:143173
37:
type:Specdb::NmrOneD
spectrum_id:143174
38:
type:Specdb::NmrOneD
spectrum_id:143175
39:
type:Specdb::NmrOneD
spectrum_id:143176
40:
type:Specdb::NmrOneD
spectrum_id:143177
41:
type:Specdb::NmrOneD
spectrum_id:143178
42:
type:Specdb::NmrOneD
spectrum_id:143179
43:
type:Specdb::NmrOneD
spectrum_id:143180
44:
type:Specdb::NmrOneD
spectrum_id:143181
45:
type:Specdb::NmrOneD
spectrum_id:143182
46:
type:Specdb::NmrOneD
spectrum_id:143183
47:
type:Specdb::NmrOneD
spectrum_id:143184
48:
type:Specdb::NmrOneD
spectrum_id:143185
49:
type:Specdb::NmrOneD
spectrum_id:143186
50:
type:Specdb::NmrOneD
spectrum_id:143187
51:
type:Specdb::NmrOneD
spectrum_id:143188
52:
type:Specdb::NmrOneD
spectrum_id:143189
生物学性质
1:
cellular:(1):Extracellular
2:
biospecimen:(1):Blood
biospecimen:(2):Cerebrospinal Fluid (CSF)
biospecimen:(3):Feces
biospecimen:(4):Saliva
biospecimen:(5):Urine
3:
tissue:(1):Erythrocyte
tissue:(2):Heart
tissue:(3):Kidney
tissue:(4):Liver
tissue:(5):Placenta
tissue:(6):Prostate
4:
[1]:
name:Riboflavin Metabolism
smpdb_id:SMP00070
kegg_map_id:map00740
正常浓度
1:
biospecimen:Blood
concentration_value:0.845 (0.361-1.77)
concentration_units:uM
subject_age:Newborn (0-30 days old)
subject_sex:Both
subject_condition:Normal
2:
biospecimen:Blood
concentration_value:0.015 (0.0054-0.028)
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
3:
biospecimen:Blood
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
4:
biospecimen:Blood
concentration_value:0.385 (0.15-0.96)
concentration_units:uM
subject_age:Children (1-13 years old)
subject_sex:Both
subject_condition:Normal
5:
biospecimen:Blood
concentration_value:0.530 (0.265-1.30)
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Female
subject_condition:Normal
6:
biospecimen:Blood
concentration_value:0.10-0.50
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
7:
biospecimen:Blood
concentration_value:0.00797-0.0399
concentration_units:uM
subject_age:Adolescent (13-18 years old)
subject_sex:Not Specified
subject_condition:Normal
8:
biospecimen:Cerebrospinal Fluid (CSF)
concentration_value:0.35 +/- 0.05
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Not Specified
subject_condition:Normal
9:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
10:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
11:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
12:
biospecimen:Saliva
concentration_value:0.710 +/- 0.180
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Female
subject_condition:Normal
13:
biospecimen:Saliva
concentration_value:0.754 +/- 0.222
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Not Specified
subject_condition:Normal
14:
biospecimen:Saliva
concentration_value:0.880 +/- 0.375
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Female
subject_condition:Normal
15:
biospecimen:Saliva
concentration_value:0.058 +/- 0.048
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
16:
biospecimen:Saliva
concentration_value:0.578 +/- 0.157
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Female
subject_condition:Normal
17:
biospecimen:Saliva
concentration_value:0.578 +/- 0.157
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Not Specified
subject_condition:Normal
18:
biospecimen:Urine
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
19:
biospecimen:Urine
concentration_value:0.18 +/- 0.08
concentration_units:umol/mmol creatinine
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
20:
biospecimen:Urine
concentration_value:0.24 +/- 0.24
concentration_units:umol/mmol creatinine
subject_age:Children (1-13 years old)
subject_sex:Both
subject_condition:Normal
21:
biospecimen:Urine
concentration_value:0.04 +/- 0.01
concentration_units:umol/mmol creatinine
subject_age:Newborn (0-30 days old)
subject_sex:Both
subject_condition:Normal
22:
biospecimen:Urine
concentration_value:0.0193 +/- 0.0139
concentration_units:umol/mmol creatinine
subject_age:Children (1 - 13 years old)
subject_sex:Both
subject_condition:Normal
23:
biospecimen:Urine
concentration_value:0.0255 +/- 0.0208
concentration_units:umol/mmol creatinine
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
异常浓度
1:
biospecimen:Blood
concentration_value:0.015 +/- 0.018
concentration_units:uM
patient_age:Adolescent (13-18 years old)
patient_sex:Female
patient_information:Anorexia nervosa
2:
biospecimen:Blood
concentration_value:0.00502
concentration_units:uM
patient_age:Adolescent (13-18 years old)
patient_sex:
patient_information:Brown-Vialetto-Van Laere Syndrome 1
3:
biospecimen:Cerebrospinal Fluid (CSF)
concentration_value:0.18 +/- 0.02
concentration_units:uM
patient_age:Adult (>18 years old)
patient_sex:Not Specified
patient_information:Alcoholism
4:
biospecimen:Cerebrospinal Fluid (CSF)
concentration_value:0.14 +/- 0.06
concentration_units:uM
patient_age:Adult (>18 years old)
patient_sex:Not Specified
patient_information:Alcoholism
5:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Colorectal cancer
6:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Colorectal Cancer
7:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Colorectal cancer
8:
biospecimen:Urine
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Colorectal adenoma
9:
biospecimen:Urine
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Cardiosvacular risk
10:
biospecimen:Urine
concentration_value:4.757 +/- 5.779
concentration_units:umol/mmol creatinine
patient_age:Children (1 - 13 years old)
patient_sex:Not Specified
patient_information:Eosinophilic esophagitis
疾病参考
1:
name:Anorexia nervosa
omim_id:606788
[1]:
reference_text:Capo-chichi CD, Gueant JL, Lefebvre E, Bennani N, Lorentz E, Vidailhet C, Vidailhet M: Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa. Am J Clin Nutr. 1999 Apr;69(4):672-8.
pubmed_id:10197568
[2]:
reference_text:Vierhapper H, Kiss A, Nowotny P, Wiesnagrotzki S, Monder C, Waldhausl W: Metabolism of cortisol in anorexia nervosa. Acta Endocrinol (Copenh). 1990 Jun;122(6):753-8.
pubmed_id:2165347
[3]:
reference_text:Anderson GM, Gerner RH, Cohen DJ, Fairbanks L: Central tryptamine turnover in depression, schizophrenia, and anorexia: measurement of indoleacetic acid in cerebrospinal fluid. Biol Psychiatry. 1984 Oct;19(10):1427-35.
pubmed_id:6518200
2:
name:Brown-Vialetto-Van Laere Syndrome 1
omim_id:211530
[1]:
reference_text:Udhayabanu T, Subramanian VS, Teafatiller T, Gowda VK, Raghavan VS, Varalakshmi P, Said HM, Ashokkumar B: SLC52A2 [p.P141T] and SLC52A3 [p.N21S] causing Brown-Vialetto-Van Laere Syndrome in an Indian patient: First genetically proven case with mutations in two riboflavin transporters. Clin Chim Acta. 2016 Nov 1;462:210-214. doi: 10.1016/j.cca.2016.09.022. Epub 2016 Oct 1.
pubmed_id:27702554
3:
name:Alcoholism
omim_id:
[1]:
reference_text:Dastur DK, Santhadevi N, Quadros EV, Avari FC, Wadia NH, Desai MN, Bharucha EP: The B-vitamins in malnutrition with alcoholism. A model of intervitamin relationships. Br J Nutr. 1976 Sep;36(2):143-59.
pubmed_id:182198
[2]:
reference_text:Viola A, Nicoli F, Denis B, Confort-Gouny S, Le Fur Y, Ranjeva JP, Viout P, Cozzone PJ: High cerebral scyllo-inositol: a new marker of brain metabolism disturbances induced by chronic alcoholism. MAGMA. 2004 Sep;17(1):47-61. Epub 2004 Aug 31.
pubmed_id:15340856
[3]:
reference_text:Brecher AS, Adamu MT: Short- and long-term effects of acetaldehyde on plasma. Alcohol. 2002 Jan;26(1):49-53.
pubmed_id:11958947
[4]:
reference_text:Nieminen LR, Makino KK, Mehta N, Virkkunen M, Kim HY, Hibbeln JR: Relationship between omega-3 fatty acids and plasma neuroactive steroids in alcoholism, depression and controls. Prostaglandins Leukot Essent Fatty Acids. 2006 Oct-Nov;75(4-5):309-14. Epub 2006 Sep 7.
pubmed_id:16959481
[5]:
reference_text:Jones AW, Lund M, Andersson E: Drinking drivers in Sweden who consume denatured alcohol preparations: an analytical-toxicological study. J Anal Toxicol. 1989 Jul-Aug;13(4):199-203.
pubmed_id:2779169
[6]:
reference_text:Jones AW, Helander A: Changes in the concentrations of ethanol, methanol and metabolites of serotonin in two successive urinary voids from drinking drivers. Forensic Sci Int. 1998 May 11;93(2-3):127-34.
pubmed_id:9717263
[7]:
reference_text:Jones AW, Lowinger H: Relationship between the concentration of ethanol and methanol in blood samples from Swedish drinking drivers. Forensic Sci Int. 1988 Jun;37(4):277-85.
pubmed_id:3410397
[8]:
reference_text:Brydon WG, Nyhlin H, Eastwood MA, Merrick MV: Serum 7 alpha-hydroxy-4-cholesten-3-one and selenohomocholyltaurine (SeHCAT) whole body retention in the assessment of bile acid induced diarrhoea. Eur J Gastroenterol Hepatol. 1996 Feb;8(2):117-23.
pubmed_id:8723414
4:
name:Colorectal cancer
omim_id:114500
[1]:
reference_text:Ishiwata S, Itoh K, Yamaguchi T, Ishida N, Mizugaki M: Comparison of serum and urinary levels of modified nucleoside, 1-methyladenosine, in cancer patients using a monoclonal antibody-based inhibition ELISA. Tohoku J Exp Med. 1995 May;176(1):61-8.
pubmed_id:7482520
[2]:
reference_text:Monleon D, Morales JM, Barrasa A, Lopez JA, Vazquez C, Celda B: Metabolite profiling of fecal water extracts from human colorectal cancer. NMR Biomed. 2009 Apr;22(3):342-8. doi: 10.1002/nbm.1345.
pubmed_id:19006102
[3]:
reference_text:Weir TL, Manter DK, Sheflin AM, Barnett BA, Heuberger AL, Ryan EP: Stool microbiome and metabolome differences between colorectal cancer patients and healthy adults. PLoS One. 2013 Aug 6;8(8):e70803. doi: 10.1371/journal.pone.0070803. Print 2013.
pubmed_id:23940645
[4]:
reference_text:Phua LC, Chue XP, Koh PK, Cheah PY, Ho HK, Chan EC: Non-invasive fecal metabonomic detection of colorectal cancer. Cancer Biol Ther. 2014 Apr;15(4):389-97. doi: 10.4161/cbt.27625. Epub 2014 Jan 14.
pubmed_id:24424155
[5]:
reference_text:Ritchie SA, Ahiahonu PW, Jayasinghe D, Heath D, Liu J, Lu Y, Jin W, Kavianpour A, Yamazaki Y, Khan AM, Hossain M, Su-Myat KK, Wood PL, Krenitsky K, Takemasa I, Miyake M, Sekimoto M, Monden M, Matsubara H, Nomura F, Goodenowe DB: Reduced levels of hydroxylated, polyunsaturated ultra long-chain fatty acids in the serum of colorectal cancer patients: implications for early screening and detection. BMC Med. 2010 Feb 15;8:13. doi: 10.1186/1741-7015-8-13.
pubmed_id:20156336
[6]:
reference_text:Qiu Y, Cai G, Su M, Chen T, Zheng X, Xu Y, Ni Y, Zhao A, Xu LX, Cai S, Jia W: Serum metabolite profiling of human colorectal cancer using GC-TOFMS and UPLC-QTOFMS. J Proteome Res. 2009 Oct;8(10):4844-50. doi: 10.1021/pr9004162.
pubmed_id:19678709
[7]:
reference_text:Cheng Y, Xie G, Chen T, Qiu Y, Zou X, Zheng M, Tan B, Feng B, Dong T, He P, Zhao L, Zhao A, Xu LX, Zhang Y, Jia W: Distinct urinary metabolic profile of human colorectal cancer. J Proteome Res. 2012 Feb 3;11(2):1354-63. doi: 10.1021/pr201001a. Epub 2011 Dec 28.
pubmed_id:22148915
[8]:
reference_text:Ni Y, Xie G, Jia W: Metabonomics of human colorectal cancer: new approaches for early diagnosis and biomarker discovery. J Proteome Res. 2014 Sep 5;13(9):3857-70. doi: 10.1021/pr500443c. Epub 2014 Aug 14.
pubmed_id:25105552
[9]:
reference_text:Ikeda A, Nishiumi S, Shinohara M, Yoshie T, Hatano N, Okuno T, Bamba T, Fukusaki E, Takenawa T, Azuma T, Yoshida M: Serum metabolomics as a novel diagnostic approach for gastrointestinal cancer. Biomed Chromatogr. 2012 May;26(5):548-58. doi: 10.1002/bmc.1671. Epub 2011 Jul 20.
pubmed_id:21773981
[10]:
reference_text:Goedert JJ, Sampson JN, Moore SC, Xiao Q, Xiong X, Hayes RB, Ahn J, Shi J, Sinha R: Fecal metabolomics: assay performance and association with colorectal cancer. Carcinogenesis. 2014 Sep;35(9):2089-96. doi: 10.1093/carcin/bgu131. Epub 2014 Jul 18.
pubmed_id:25037050
[11]:
reference_text:Sinha R, Ahn J, Sampson JN, Shi J, Yu G, Xiong X, Hayes RB, Goedert JJ: Fecal Microbiota, Fecal Metabolome, and Colorectal Cancer Interrelations. PLoS One. 2016 Mar 25;11(3):e0152126. doi: 10.1371/journal.pone.0152126. eCollection 2016.
pubmed_id:27015276
[12]:
reference_text:Lin Y, Ma C, Liu C, Wang Z, Yang J, Liu X, Shen Z, Wu R: NMR-based fecal metabolomics fingerprinting as predictors of earlier diagnosis in patients with colorectal cancer. Oncotarget. 2016 May 17;7(20):29454-64. doi: 10.18632/oncotarget.8762.
pubmed_id:27107423
[13]:
reference_text:Brown DG, Rao S, Weir TL, O'Malia J, Bazan M, Brown RJ, Ryan EP: Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool. Cancer Metab. 2016 Jun 6;4:11. doi: 10.1186/s40170-016-0151-y. eCollection 2016.
pubmed_id:27275383
[14]:
reference_text:Wang X, Wang J, Rao B, Deng L: Gut flora profiling and fecal metabolite composition of colorectal cancer patients and healthy individuals. Exp Ther Med. 2017 Jun;13(6):2848-2854. doi: 10.3892/etm.2017.4367. Epub 2017 Apr 20.
pubmed_id:28587349
[15]:
reference_text:Silke Matysik, Caroline Ivanne Le Roy, Gerhard Liebisch, Sandrine Paule Claus. Metabolomics of fecal samples: A practical consideration. Trends in Food Science & Technology. Vol. 57, Part B, Nov. 2016, p.244-255: http://www.sciencedirect.com/science/article/pii/S0924224416301984
5:
name:Eosinophilic esophagitis
omim_id:610247
[1]:
reference_text:Mordechai, Hien, and David S. Wishart
pubmed_id:
综合参考
Tishler, Max; Pfister, Karl, III; Babson, R. D.; Ladenburg, Kurt; Fleming, Ann J. Reaction between o-aminoazo compounds and barbituric acid. A new synthesis of riboflavin. Journal of the American Chemical Society (1947), 69 1487-92.
一般参考
1:
protein_accession:HMDBP00094
name:Lysosomal acid phosphatase
uniprot_id:P11117
gene_name:ACP2
protein_type:Enzyme
2:
protein_accession:HMDBP00095
name:Low molecular weight phosphotyrosine protein phosphatase
uniprot_id:P24666
gene_name:ACP1
protein_type:Enzyme
3:
protein_accession:HMDBP00097
name:Tartrate-resistant acid phosphatase type 5
uniprot_id:P13686
gene_name:ACP5
protein_type:Unknown
4:
protein_accession:HMDBP00098
name:Prostatic acid phosphatase
uniprot_id:P15309
gene_name:ACPP
protein_type:Enzyme
5:
protein_accession:HMDBP00169
name:Amine oxidase [flavin-containing] A
uniprot_id:P21397
gene_name:MAOA
protein_type:Unknown
6:
protein_accession:HMDBP00188
name:Methylenetetrahydrofolate reductase
uniprot_id:P42898
gene_name:MTHFR
protein_type:Unknown
7:
protein_accession:HMDBP00370
name:Glycogen phosphorylase, liver form
uniprot_id:P06737
gene_name:PYGL
protein_type:Enzyme
8:
protein_accession:HMDBP00701
name:Flavin reductase (NADPH)
uniprot_id:P30043
gene_name:BLVRB
protein_type:Unknown
9:
protein_accession:HMDBP01059
name:Riboflavin kinase
uniprot_id:Q969G6
gene_name:RFK
protein_type:Unknown
10:
protein_accession:HMDBP02616
name:Solute carrier family 52, riboflavin transporter, member 1
uniprot_id:Q9NWF4
gene_name:SLC52A1
protein_type:Enzyme
11:
protein_accession:HMDBP07315
name:Lysophosphatidic acid phosphatase type 6
uniprot_id:Q9NPH0
gene_name:ACP6
protein_type:Enzyme
12:
protein_accession:HMDBP07986
name:Solute carrier family 22 member 6
uniprot_id:Q4U2R8
gene_name:SLC22A6
protein_type:Transporter
13:
protein_accession:HMDBP09380
name:Testicular acid phosphatase
uniprot_id:Q9BZG2
gene_name:ACPT
protein_type:Enzyme
14:
protein_accession:HMDBP10465
name:Putative uncharacterized protein ACP1
uniprot_id:B5MCC7
gene_name:ACP1
protein_type:Enzyme
蛋白质结合
1:
reference_text:Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762.
pubmed_id:19212411
2:
reference_text:Mathew JL, Kabi BC, Rath B: Anti-oxidant vitamins and steroid responsive nephrotic syndrome in Indian children. J Paediatr Child Health. 2002 Oct;38(5):450-37.
pubmed_id:12354259
3:
reference_text:Booth CK, Clark T, Fenn A: Folic acid, riboflavin, thiamine, and vitamin B-6 status of a group of first-time blood donors. Am J Clin Nutr. 1998 Nov;68(5):1075-80.
pubmed_id:9808225
4:
reference_text:Boisvert WA, Mendoza I, Castaneda C, De Portocarrero L, Solomons NW, Gershoff SN, Russell RM: Riboflavin requirement of healthy elderly humans and its relationship to macronutrient composition of the diet. J Nutr. 1993 May;123(5):915-25.
pubmed_id:8487103
5:
reference_text:Mikalunas V, Fitzgerald K, Rubin H, McCarthy R, Craig RM: Abnormal vitamin levels in patients receiving home total parenteral nutrition. J Clin Gastroenterol. 2001 Nov-Dec;33(5):393-6.
pubmed_id:11606856
6:
reference_text:Belko AZ, Obarzanek E, Roach R, Rotter M, Urban G, Weinberg S, Roe DA: Effects of aerobic exercise and weight loss on riboflavin requirements of moderately obese, marginally deficient young women. Am J Clin Nutr. 1984 Sep;40(3):553-61.
pubmed_id:6475825
7:
reference_text:Alexander M, Emanuel G, Golin T, Pinto JT, Rivlin RS: Relation of riboflavin nutriture in healthy elderly to intake of calcium and vitamin supplements: evidence against riboflavin supplementation. Am J Clin Nutr. 1984 Apr;39(4):540-6.
pubmed_id:6546833
8:
reference_text:Baeckert PA, Greene HL, Fritz I, Oelberg DG, Adcock EW: Vitamin concentrations in very low birth weight infants given vitamins intravenously in a lipid emulsion: measurement of vitamins A, D, and E and riboflavin. J Pediatr. 1988 Dec;113(6):1057-65.
pubmed_id:3142982
9:
reference_text:Maiani G, Mobarhan S, Nicastro A, Virgili F, Scaccini C, Ferro-Luzzi A: [Determination of glutathione reductase activity in erythrocytes and whole blood as an indicator of riboflavin nutrition]. Acta Vitaminol Enzymol. 1983;5(3):171-8.
pubmed_id:6650303
10:
reference_text:Bamji MS, Bhaskaram P, Jacob CM: Urinary riboflavin excretion and erythrocyte glutathione reductase activity in preschool children suffering from upper respiratory infections and measles. Ann Nutr Metab. 1987;31(3):191-6.
pubmed_id:3592624
11:
reference_text:Ajayi OA: Bioavailability of riboflavin from fortified palm juice. Plant Foods Hum Nutr. 1989 Dec;39(4):375-80.
pubmed_id:2631092
12:
reference_text:Kodentsova VM, Vrzhesinskaya OA, Spirichev VB: Fluorometric riboflavin titration in plasma by riboflavin-binding apoprotein as a method for vitamin B2 status assessment. Ann Nutr Metab. 1995;39(6):355-60.
pubmed_id:8678471
13:
reference_text:Bates CJ, Powers HJ: A simple fluorimetric assay for pyridoxamine phosphate oxidase in erythrocyte haemolysates: effects of riboflavin supplementation and of glucose 6-phosphate dehydrogenase deficiency. Hum Nutr Clin Nutr. 1985 Mar;39(2):107-15.
pubmed_id:4019261
14:
reference_text:Brun TA, Chen J, Campbell TC, Boreham J, Feng Z, Parpia B, Shen TF, Li M: Urinary riboflavin excretion after a load test in rural China as a measure of possible riboflavin deficiency. Eur J Clin Nutr. 1990 Mar;44(3):195-206.
pubmed_id:2369885
15:
reference_text:Mulherin DM, Thurnham DI, Situnayake RD: Glutathione reductase activity, riboflavin status, and disease activity in rheumatoid arthritis. Ann Rheum Dis. 1996 Nov;55(11):837-40.
pubmed_id:8976642
16:
reference_text:Rao PN, Levine E, Myers MO, Prakash V, Watson J, Stolier A, Kopicko JJ, Kissinger P, Raj SG, Raj MH: Elevation of serum riboflavin carrier protein in breast cancer. Cancer Epidemiol Biomarkers Prev. 1999 Nov;8(11):985-90.
pubmed_id:10566553
17:
reference_text:Zhou X, Huang C, Hong J, Yao S: [Nested case-control study on riboflavin levels in blood and urine and the risk of lung cancer]. Wei Sheng Yan Jiu. 2003 Nov;32(6):597-8, 601.
pubmed_id:14963913
18:
reference_text:Thurnham DI, Zheng SF, Munoz N, Crespi M, Grassi A, Hambidge KM, Chai TF: Comparison of riboflavin, vitamin A, and zinc status of Chinese populations at high and low risk for esophageal cancer. Nutr Cancer. 1985;7(3):131-43.
pubmed_id:3878498
19:
reference_text:Bates CJ, Prentice AM, Paul AA, Prentice A, Sutcliffe BA, Whitehead RG: Riboflavin status in infants born in rural Gambia, and the effect of a weaning food supplement. Trans R Soc Trop Med Hyg. 1982;76(2):253-8.
pubmed_id:7101408
20:
reference_text:Dror Y, Stern F, Komarnitsky M: Optimal and stable conditions for the determination of erythrocyte glutathione reductase activation coefficient to evaluate riboflavin status. Int J Vitam Nutr Res. 1994;64(4):257-62.
pubmed_id:7883462
21:
reference_text:Switzer BR, Stark AH, Atwood JR, Ritenbaugh C, Travis RG, Wu HM: Development of a urinary riboflavin adherence marker for a wheat bran fiber community intervention trial. Cancer Epidemiol Biomarkers Prev. 1997 Jun;6(6):439-42.
pubmed_id:9184778
22:
reference_text:Zempleni J, Galloway JR, McCormick DB: Pharmacokinetics of orally and intravenously administered riboflavin in healthy humans. Am J Clin Nutr. 1996 Jan;63(1):54-66.
pubmed_id:8604671
23:
reference_text:Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043.
pubmed_id:32033212