版本
5.0
创建日期
2005-11-16 15:48:42 UTC
更新日期
2021-09-07 16:24:13 UTC
登录号
HMDB0000243
地位
quantified
二级访问
HMDB00243

名称
Pyruvic acid
描述
Pyruvic acid or pyruvate is a simple alpha-keto acid. It is a three-carbon molecule containing a carboxylic acid group and a ketone functional group. Pyruvate is the simplest alpha-keto acid and according to official nomenclature by IUPAC, it is called alpha-keto propanoic acid. Like other keto acids, pyruvic acid can tautomerize from its ketone form to its enol form, containing a double bond and an alcohol. Pyruvate is found in all living organisms ranging from bacteria to plants to humans. It is intermediate compound in the metabolism of carbohydrates, proteins, and fats. Pyruvate is a key intermediate in several metabolic pathways throughout the cell. In particular, pyruvic acid can be made from glucose through glycolysis, converted back to carbohydrates (such as glucose) via gluconeogenesis, or to fatty acids through a reaction with acetyl-CoA. Pyruvic acid supplies energy to cells through the citric acid cycle (TCA or Krebs cycle) when oxygen is present (aerobic respiration), and alternatively ferments to produce lactate when oxygen is lacking (lactic acid). In glycolysis, phosphoenolpyruvate (PEP) is converted to pyruvate by pyruvate kinase. This reaction is strongly exergonic and irreversible. In gluconeogenesis, it takes two enzymes, pyruvate carboxylase and PEP carboxykinase, to catalyze the reverse transformation of pyruvate to PEP. Pyruvic acid is also a metabolite of Corynebacterium (PMID: 27872963).
同义词
1:2-Ketopropionic acid

2:2-Oxopropanoic acid

3:2-Oxopropansaeure

4:2-Oxopropionsaeure

5:Acetylformic acid

6:Acide pyruvique

7:alpha-Ketopropionic acid

8:alpha-Oxopropionsaeure

9:Brenztraubensaeure

10:BTS

11:CH3COCOOH

12:Pyroracemic acid

13:2-Oxopropanoate

14:2-Ketopropionate

15:Acetylformate

16:a-Ketopropionate

17:a-Ketopropionic acid

18:alpha-Ketopropionate

19:Α-ketopropionate

20:Α-ketopropionic acid

21:a-Oxopropionsaeure

22:Α-oxopropionsaeure

23:Pyroracemate

24:Pyruvate

25:2-Oxopropionate

26:2-Oxopropionic acid

27:Acid, pyruvic

28:Pyruvic acid

29:alpha-Ketopropanoic acid

30:α-Ketopropanoic acid

化学式
C3H4O3
平均分子量
88.0621
等位分子量
88.016043994
化学名称
2-oxopropanoic acid
传统名称
pyruvic acid
CAS 登记号
127-17-3
代谢物结构字符串
CC(=O)C(O)=O
inchi标识符
InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)
印记键
LCTONWCANYUPML-UHFFFAOYSA-N
分类学
description: belongs to the class of organic compounds known as alpha-keto acids and derivatives. These are organic compounds containing an aldehyde substituted with a keto group on the adjacent carbon.

description:Alpha-keto acids and derivatives

kingdom:Organic compounds

super_class:Organic acids and derivatives

class:Keto acids and derivatives

sub_class:Alpha-keto acids and derivatives

molecular_framework:Aliphatic acyclic compounds

1:Alpha-hydroxy ketones

2:Carboxylic acids

3:Hydrocarbon derivatives

4:Monocarboxylic acids and derivatives

5:Organic oxides

6:Aliphatic acyclic compound

7:Alpha-hydroxy ketone

8:Alpha-keto acid

9:Carbonyl group

10:Carboxylic acid

11:Carboxylic acid derivative

12:Hydrocarbon derivative

13:Ketone

14:Monocarboxylic acid or derivatives

15:Organic oxide

16:Organic oxygen compound

17:Organooxygen compound

18:2-oxo monocarboxylic acid

19:Oxo fatty acids

本体论
term:Physiological effect

definition:The effect on an organism physiology, resulting from its exposure to a chemical.

parent_id:

level:1

type:parent

term:Health effect

definition:A health condition or observation associated with a stimuli or with a biological activity of a chemical.

parent_id:7693

*level:2

type:parent

term:Health condition

definition:A health effect that consists on short or long-term disease, condition, disorder, syndrome or constant abnormality.

parent_id:7694

**level:3

type:parent

term:Schizophrenia

definition:A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness. (do).

parent_id:7695

***level:4

type:child

term:Anoxia

definition:

parent_id:7695

***level:4

type:child

term:Metabolism and nutrition disorders

definition:A group of disorders, inherited or not, that result in a metabolic malfunction.

parent_id:7695

***level:4

type:parent

term:Infections and infestations

definition:Any disorder resulting from the presence and activity of a microbial, viral, or parasitic agent. it can be transmitted by direct or indirect contact. (nci).

parent_id:7695

***level:4

type:parent

term:Disposition

definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.

parent_id:

level:1

type:parent

term:Route of exposure

definition:A mean by which a chemical agent comes in contact with an organism, either under intended or unintended circumstances.

parent_id:7724

*level:2

type:parent

term:Enteral

definition:Chemical exposure via the alimentary canal (mouth to anus).

parent_id:7743

**level:3

type:parent

term:Gastrointestinal

definition:Chemical exposure by absorption through the stomach and intestines.

parent_id:7744

***level:4

type:child

synonym:Gi tract

term:Ingestion

definition:Chemical exposure facilitated by entry through the mouth.

parent_id:7744

***level:4

type:child

synonym:Digestion

term:Source

definition:Natural or synthetic origin of a chemical.

parent_id:7724

*level:2

type:parent

term:Endogenous

definition:

parent_id:7735

**level:3

type:child

term:Food

definition:

parent_id:7735

**level:3

type:child

term:Biological

definition:A living organism (species or a higher taxonomy rank), in which a chemical can be found.

parent_id:7735

**level:3

type:parent

term:Animal

definition:A living organism belonging to the kingdom animalia. it feeds on organic matter, typically having specialized sense organs and nervous system and able to respond rapidly to stimuli.

parent_id:7736

***level:4

type:child

synonym:Fauna

term:Saccharomyces cerevisiae

definition:

parent_id:7736

***level:4

type:child

synonym:Baker's yeast

term:Microbe

definition:A living organism that is of a microscopic scale, either single-celled or a cluster of cells.

parent_id:7736

***level:4

type:parent

term:Plant

definition:A living organism belonging to the kingdom plantea. typically, it grows in a permanent site, absorbs water and inorganic substances through its roots, and synthesizes nutrients in its leaves by photosynthesis using the green pigment chlorophyll. examples incude trees, shrubs, herbs, grasses, ferns, and mosses.

parent_id:7736

***level:4

type:parent

synonym:Flora

term:Biological location

definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.

parent_id:7724

*level:2

type:parent

term:Tissue and substructures

definition:An anatomical organizational level including multiple cells yet not comprising a complete organ .

parent_id:7725

**level:3

type:parent

term:Skeletal muscle

definition:Striated muscles that are under voluntary control of the organism. they are connected at either or both ends to a bone and are utilized for locomotion and other movements. (nci).

parent_id:7729

***level:4

type:child

synonym:Striated muscle

term:Adipose tissue

definition:A specialized form of connective tissue consisting primarily of adipocytes (fat cells), surrounded by a meshwork of collagen fibers. (NCI)

parent_id:7729

***level:4

type:child

synonym:Fat tissue

synonym:Body fat

synonym:Adipose

term:Cardiac muscle

definition:The striated muscle tissue of the heart enveloped by the epicardium and the endocardium.

parent_id:7729

***level:4

type:child

synonym:Myocardium

synonym:Myocardial tissue

synonym:Heart muscle

term:Muscle

definition:A fibrous soft tissue with the ability to contract to produce force and motion. (nci).

parent_id:7729

***level:4

type:child

term:Placenta

definition:An organ present in some vertebrates during embryonic gestation that surrounds the fetus and provides it with nutrients and oxygen, facilitates gas and waste exchange between the fetus and mother, and provides parasitic cloaking from the mother's immune system by excretion of neurokinin b. (nci).

parent_id:7729

***level:4

type:child

term:Organ and components

definition:An anatomical organizational level including multiple tissues or substructures, which enables a common biological function.

parent_id:7725

**level:3

type:parent

term:Testicle

definition:Either of the paired male reproductive glands that produce the male germ cells and the male hormones. (nci).

parent_id:7727

***level:4

type:child

synonym:Testes

synonym:Testis

term:Spleen

definition:An abdominal organ that is part of the hematopoietic and immune systems. it is composed of the white pulp and the red pulp and is surrounded by a capsule. (nci).

parent_id:7727

***level:4

type:child

term:Brain

definition:An organ composed of grey and white matter that is the center for intelligence and reasoning. it is protected by the bony cranium. (nci).

parent_id:7727

***level:4

type:child

term:Liver

definition:An abdominal organ that has variable lobation which are composed mainly of hepatic lobules. (nci).

parent_id:7727

***level:4

type:child

term:Kidney

definition:The organs of the urinary tract located in the retroperitoneal cavity adjacent to the spine and composed of the renal cortex and the renal medulla. (nci).

parent_id:7727

***level:4

type:child

synonym:Kidneys

term:Pancreas

definition:A digestive organ in the abdomen that has both endocrine and exocrine functions. (nci).

parent_id:7727

***level:4

type:child

term:Endocrine gland

definition:

parent_id:7727

***level:4

type:parent

term:Biofluid and excreta

definition:A liquid, semi-solid or solid material originating in the body.

parent_id:7725

**level:3

type:parent

term:Urine

definition:Excretion in liquid state processed by the kidney.

parent_id:7731

***level:4

type:child

term:Breast milk

definition:Portion of secreted substance produced by the mammary gland.

parent_id:7731

***level:4

type:child

term:Saliva

definition:The watery fluid in the mouth made by the salivary glands. saliva moistens food to help digestion and it helps protect the mouth against infections. (nci).

parent_id:7731

***level:4

type:child

term:Feces

definition:The material discharged from the bowel during defecation. It consists of undigested food, intestinal mucus, epithelial cells, and bacteria.

parent_id:7731

***level:4

type:child

synonym:Fecal

synonym:Stool

synonym:Faecal

synonym:Faeces

term:Blood

definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.

parent_id:7731

***level:4

type:child

term:Sweat

definition:Secretion produced by a sweat gland.

parent_id:7731

***level:4

type:child

term:Cerebrospinal fluid

definition:The fluid that is contained within the brain ventricles, the subarachnoid space and the central canal of the spinal cord. (nci).

parent_id:7731

***level:4

type:child

synonym:Csf

term:Cell and elements

definition:An anatomical organizational level comprising of a single cell (or a fragment in some exceptions). a cell is defined by its type or function. it is the smallest unit of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid.

parent_id:7725

**level:3

type:parent

term:Extracellular

definition:The space external to the outermost structure of a cell.

parent_id:7732

***level:4

type:child

synonym:Extracellular region

term:Cell

definition:

parent_id:7732

***level:4

type:parent

term:Subcellular

definition:An anatomical organizational level including a component within a biological cell .

parent_id:7725

**level:3

type:parent

term:Mitochondria

definition:

parent_id:7730

***level:4

type:child

term:Peroxisome

definition:A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. (Gene Ontology).

parent_id:7730

***level:4

type:child

synonym:Peroxisome vesicle

synonym:Peroxisomal

term:Cytoplasm

definition:The portion of the cell contained within the plasma membrane but excluding the nucleus.

parent_id:7730

***level:4

type:child

synonym:Cytoplasma

term:Process

definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.

parent_id:

level:1

type:parent

term:Naturally occurring process

definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.

parent_id:7659

*level:2

type:parent

term:Biological process

definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.

parent_id:7660

**level:3

type:parent

term:Biochemical pathway

definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.

parent_id:7661

***level:4

type:parent

term:Role

definition:The purpose or function assumed by a chemical, either naturally or as intended by humans .

parent_id:

level:1

type:parent

term:Industrial application

definition:The assumed function of a chemical utilized by human.

parent_id:7671

*level:2

type:parent

term:Food and nutrition

definition:A chemical purpose related to manufacturing of food and nutrition products.

parent_id:7678

**level:3

type:child

term:Pharmaceutical industry

definition:A pharmacologic activity for which a chemical substance is utilized owing to its biological role.

parent_id:7678

**level:3

type:parent

term:Pharmaceutical

definition:

parent_id:7679

***level:4

type:child

term:Biological role

definition:The biological function of a chemical. the biological role answers the question how a chemical is involved in molecular processes in an organism. this can include biochemical effects of non-endogenous chemicals, which are also assigned an industrial application such as pharmaceuticals. the biological role is limited to cellular levls, and will not include role at system process level, such as a chemical which has a role in a disease.

parent_id:7671

*level:2

type:parent

term:Energy source

definition:

parent_id:7672

**level:3

type:child

term:Antioxidant

definition:a chemical substance that is used to maintain the quality, integrity, and safety of finished products by inhibiting the oxidative degradation of the ingredients in the formulation. Also referred to as a preservative

parent_id:7672

**level:3

type:child

synonym:Anti-oxidant

term:Metabolite

definition:A chemical substance produced during metabolism process, as an intermediate or end-product.

parent_id:7672

**level:3

type:child

状态
Liquid
实验性质
1:

kind:water_solubility

value:1000.0 mg/mL

source:

2:

kind:melting_point

value:13.8 °C

source:

预测性质
1:

kind:logp

value:-0.38

source:ALOGPS

2:

kind:logs

value:0.18

source:ALOGPS

3:

kind:solubility

value:134 g/L

source:ALOGPS

4:

kind:logp

value:0.066

source:ChemAxon

5:

kind:pka_strongest_acidic

value:2.93

source:ChemAxon

6:

kind:pka_strongest_basic

value:-9.6

source:ChemAxon

7:

kind:iupac

value:2-oxopropanoic acid

source:ChemAxon

8:

kind:average_mass

value:88.0621

source:ChemAxon

9:

kind:mono_mass

value:88.016043994

source:ChemAxon

10:

kind:smiles

value:CC(=O)C(O)=O

source:ChemAxon

11:

kind:formula

value:C3H4O3

source:ChemAxon

12:

kind:inchi

value:InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)

source:ChemAxon

13:

kind:inchikey

value:LCTONWCANYUPML-UHFFFAOYSA-N

source:ChemAxon

14:

kind:polar_surface_area

value:54.37

source:ChemAxon

15:

kind:refractivity

value:17.99

source:ChemAxon

16:

kind:polarizability

value:7.31

source:ChemAxon

17:

kind:rotatable_bond_count

value:1

source:ChemAxon

18:

kind:acceptor_count

value:3

source:ChemAxon

19:

kind:donor_count

value:1

source:ChemAxon

20:

kind:physiological_charge

value:-1

source:ChemAxon

21:

kind:formal_charge

value:0

source:ChemAxon

22:

kind:number_of_rings

value:0

source:ChemAxon

23:

kind:bioavailability

value:Yes

source:ChemAxon

24:

kind:rule_of_five

value:Yes

source:ChemAxon

25:

kind:ghose_filter

value:No

source:ChemAxon

26:

kind:veber_rule

value:No

source:ChemAxon

27:

kind:mddr_like_rule

value:No

source:ChemAxon

光谱
生物学性质
1:

cellular:(1):Extracellular

cellular:(2):Mitochondria

cellular:(3):Peroxisome

2:

biospecimen:(1):Blood

biospecimen:(2):Breast Milk

biospecimen:(3):Cellular Cytoplasm

biospecimen:(4):Cerebrospinal Fluid (CSF)

biospecimen:(5):Feces

biospecimen:(6):Saliva

biospecimen:(7):Sweat

biospecimen:(8):Urine

3:

tissue:(1):Adipose Tissue

tissue:(2):Brain

tissue:(3):Fibroblasts

tissue:(4):Heart

tissue:(5):Kidney

tissue:(6):Liver

tissue:(7):Neuron

tissue:(8):Pancreas

tissue:(9):Placenta

tissue:(10):Skeletal Muscle

tissue:(11):Spleen

tissue:(12):Testis

tissue:(13):Thyroid Gland

4:

[1]:

name:2-Hydroxyglutric Aciduria (D And L Form)

smpdb_id:SMP00136

kegg_map_id:

[2]:

name:2-ketoglutarate dehydrogenase complex deficiency

smpdb_id:SMP00549

kegg_map_id:

[3]:

name:3-Phosphoglycerate dehydrogenase deficiency

smpdb_id:SMP00721

kegg_map_id:

[4]:

name:4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency

smpdb_id:SMP00243

kegg_map_id:

[5]:

name:Alanine, aspartate and glutamate metabolism

smpdb_id:

kegg_map_id:map00250

[6]:

name:Amino Sugar Metabolism

smpdb_id:SMP00045

kegg_map_id:map00520

[7]:

name:Argininemia

smpdb_id:SMP00357

kegg_map_id:

[8]:

name:Argininosuccinic Aciduria

smpdb_id:SMP00003

kegg_map_id:

[9]:

name:Beta-mercaptolactate-cysteine disulfiduria

smpdb_id:SMP00499

kegg_map_id:

[10]:

name:Carbamoyl Phosphate Synthetase Deficiency

smpdb_id:SMP00002

kegg_map_id:

[11]:

name:Citric Acid Cycle

smpdb_id:SMP00057

kegg_map_id:map00020

[12]:

name:Citrullinemia Type I

smpdb_id:SMP00001

kegg_map_id:

[13]:

name:Congenital lactic acidosis

smpdb_id:SMP00546

kegg_map_id:

[14]:

name:Cysteine Metabolism

smpdb_id:SMP00013

kegg_map_id:map00270

[15]:

name:Cystinosis, ocular nonnephropathic

smpdb_id:SMP00722

kegg_map_id:

[16]:

name:Dihydropyrimidine Dehydrogenase Deficiency (DHPD)

smpdb_id:SMP00179

kegg_map_id:

[17]:

name:Dimethylglycine Dehydrogenase Deficiency

smpdb_id:SMP00242

kegg_map_id:

[18]:

name:Dimethylglycine Dehydrogenase Deficiency

smpdb_id:SMP00484

kegg_map_id:

[19]:

name:Fanconi-bickel syndrome

smpdb_id:SMP00572

kegg_map_id:

[20]:

name:Fructose-1,6-diphosphatase deficiency

smpdb_id:SMP00562

kegg_map_id:

[21]:

name:Fumarase deficiency

smpdb_id:SMP00547

kegg_map_id:

[22]:

name:G(M2)-Gangliosidosis: Variant B, Tay-sachs disease

smpdb_id:SMP00534

kegg_map_id:

[23]:

name:Glucose-Alanine Cycle

smpdb_id:SMP00127

kegg_map_id:

[24]:

name:Glutamate Metabolism

smpdb_id:SMP00072

kegg_map_id:map00250

[25]:

name:Glutaminolysis and Cancer

smpdb_id:SMP02298

kegg_map_id:

[26]:

name:Glycine, serine and threonine metabolism

smpdb_id:

kegg_map_id:map00260

[27]:

name:Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease

smpdb_id:SMP00374

kegg_map_id:

[28]:

name:Glycogenosis, Type IA. Von gierke disease

smpdb_id:SMP00581

kegg_map_id:

[29]:

name:Glycogenosis, Type IB

smpdb_id:SMP00573

kegg_map_id:

[30]:

name:Glycogenosis, Type IC

smpdb_id:SMP00574

kegg_map_id:

[31]:

name:Glycogenosis, Type VII. Tarui disease

smpdb_id:SMP00531

kegg_map_id:

[32]:

name:Glycolysis / Gluconeogenesis

smpdb_id:

kegg_map_id:map00010

[33]:

name:Glycolysis / Gluconeogenesis

smpdb_id:

kegg_map_id:map00010

[34]:

name:Homocarnosinosis

smpdb_id:SMP00385

kegg_map_id:

[35]:

name:Hyperglycinemia, non-ketotic

smpdb_id:SMP00485

kegg_map_id:

[36]:

name:Hyperinsulinism-Hyperammonemia Syndrome

smpdb_id:SMP00339

kegg_map_id:

[37]:

name:Lactic Acidemia

smpdb_id:SMP00313

kegg_map_id:

[38]:

name:Leigh Syndrome

smpdb_id:SMP00196

kegg_map_id:

[39]:

name:Mitochondrial complex II deficiency

smpdb_id:SMP00548

kegg_map_id:

[40]:

name:Nitrogen metabolism

smpdb_id:

kegg_map_id:map00910

[41]:

name:Non Ketotic Hyperglycinemia

smpdb_id:SMP00223

kegg_map_id:

[42]:

name:Ornithine Transcarbamylase Deficiency (OTC Deficiency)

smpdb_id:SMP00205

kegg_map_id:

[43]:

name:Phosphoenolpyruvate carboxykinase deficiency 1 (PEPCK1)

smpdb_id:SMP00560

kegg_map_id:

[44]:

name:Primary hyperoxaluria II, PH2

smpdb_id:SMP00558

kegg_map_id:

[45]:

name:Primary Hyperoxaluria Type I

smpdb_id:SMP00352

kegg_map_id:

[46]:

name:Pyruvaldehyde Degradation

smpdb_id:SMP00459

kegg_map_id:

[47]:

name:Pyruvate Carboxylase Deficiency

smpdb_id:SMP00350

kegg_map_id:

[48]:

name:Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency)

smpdb_id:SMP00334

kegg_map_id:

[49]:

name:Pyruvate Dehydrogenase Complex Deficiency

smpdb_id:SMP00212

kegg_map_id:

[50]:

name:Pyruvate dehydrogenase deficiency (E2)

smpdb_id:SMP00551

kegg_map_id:

[51]:

name:Pyruvate dehydrogenase deficiency (E3)

smpdb_id:SMP00550

kegg_map_id:

[52]:

name:Pyruvate kinase deficiency

smpdb_id:SMP00559

kegg_map_id:

[53]:

name:Pyruvate metabolism

smpdb_id:

kegg_map_id:map00620

[54]:

name:Salla Disease/Infantile Sialic Acid Storage Disease

smpdb_id:SMP00240

kegg_map_id:

[55]:

name:Sarcosinemia

smpdb_id:SMP00244

kegg_map_id:

[56]:

name:Sialuria or French Type Sialuria

smpdb_id:SMP00216

kegg_map_id:

[57]:

name:Succinic semialdehyde dehydrogenase deficiency

smpdb_id:SMP00567

kegg_map_id:

[58]:

name:Tay-Sachs Disease

smpdb_id:SMP00390

kegg_map_id:

[59]:

name:The oncogenic action of 2-hydroxyglutarate

smpdb_id:SMP02291

kegg_map_id:

[60]:

name:The oncogenic action of D-2-hydroxyglutarate in Hydroxygluaricaciduria

smpdb_id:SMP02359

kegg_map_id:

[61]:

name:The Oncogenic Action of Fumarate

smpdb_id:SMP02295

kegg_map_id:

[62]:

name:The oncogenic action of L-2-hydroxyglutarate in Hydroxygluaricaciduria

smpdb_id:SMP02358

kegg_map_id:

[63]:

name:The Oncogenic Action of Succinate

smpdb_id:SMP02292

kegg_map_id:

[64]:

name:Transfer of Acetyl Groups into Mitochondria

smpdb_id:SMP00466

kegg_map_id:

[65]:

name:Triosephosphate isomerase

smpdb_id:SMP00563

kegg_map_id:

[66]:

name:Urea Cycle

smpdb_id:SMP00059

kegg_map_id:map00330

[67]:

name:Warburg Effect

smpdb_id:SMP00654

kegg_map_id:

正常浓度
1:

biospecimen:Blood

concentration_value:34.5 +/- 25.2

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

2:

biospecimen:Blood

concentration_value:<150

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Not Specified

subject_condition:Normal

3:

biospecimen:Blood

concentration_value:<200

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

4:

biospecimen:Blood

concentration_value:64 (22-258)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

5:

biospecimen:Blood

concentration_value:100 (50-190)

concentration_units:uM

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

6:

biospecimen:Blood

concentration_value:56.778

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

7:

biospecimen:Blood

concentration_value:81.0 +/- 34.0

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

8:

biospecimen:Blood

concentration_value:76.0 +/- 10.0

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Both

subject_condition:Normal

9:

biospecimen:Blood

concentration_value:63.0 +/- 25.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

10:

biospecimen:Blood

concentration_value:40-100

concentration_units:uM

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

11:

biospecimen:Blood

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

12:

biospecimen:Blood

concentration_value:75.5 (10.0-141.0)

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Not Specified

subject_condition:Normal

13:

biospecimen:Blood

concentration_value:50-140

concentration_units:uM

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

14:

biospecimen:Blood

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

15:

biospecimen:Blood

concentration_value:40-70

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

16:

biospecimen:Blood

concentration_value:<200

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

17:

biospecimen:Blood

concentration_value:22.00-258.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

18:

biospecimen:Blood

concentration_value:64 (28-145)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

19:

biospecimen:Blood

concentration_value:64 (29-144)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

20:

biospecimen:Blood

concentration_value:67 (27-164)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

21:

biospecimen:Blood

concentration_value:64 (29-144)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

22:

biospecimen:Blood

concentration_value:66 (34-117)

concentration_units:uM

subject_age:Elderly (>65 years old)

subject_sex:Both

subject_condition:Normal

23:

biospecimen:Blood

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

24:

biospecimen:Breast Milk

concentration_value:5.7 +/- 3.3

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

25:

biospecimen:Cellular Cytoplasm

concentration_value:77.0 (27.0-127)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

26:

biospecimen:Cellular Cytoplasm

concentration_value:360 (350-370)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

27:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:153.0 (121.0-185.0)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

28:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:27 +/- 11

concentration_units:uM

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

29:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:30 -130

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:Male

subject_condition:Normal

30:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:53 +/- 42

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

31:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:71.0 +/- 31.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

32:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:50-140

concentration_units:uM

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

33:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:115.0 +/- 17.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

34:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:136.0 +/- 29.0

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Both

subject_condition:Normal

35:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

36:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

37:

biospecimen:Feces

concentration_value:13361.783 (3633.799-23089.767)

concentration_units:nmol/g wet feces

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

38:

biospecimen:Feces

concentration_value:27783.424 (17336.251-38230.597)

concentration_units:nmol/g wet feces

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

39:

biospecimen:Feces

concentration_value:62607.334 (33271.975-91942.693)

concentration_units:nmol/g wet feces

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

40:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

41:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

42:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

43:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

44:

biospecimen:Saliva

concentration_value:43.3 +/- 65.1

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

45:

biospecimen:Saliva

concentration_value:62.5 +/- 47.1

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

46:

biospecimen:Saliva

concentration_value:9 (<1-78)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

47:

biospecimen:Saliva

concentration_value:32 (<1-849)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

48:

biospecimen:Saliva

concentration_value:68.6 +/- 69.1

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

49:

biospecimen:Saliva

concentration_value:36 (9-395)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

50:

biospecimen:Saliva

concentration_value:15 (7-91)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

51:

biospecimen:Saliva

concentration_value:350 +/- 740

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

52:

biospecimen:Saliva

concentration_value:2310 +/- 3470

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

53:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

54:

biospecimen:Saliva

concentration_value:1830 +/- 2960

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

55:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

56:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

57:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

58:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

59:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

60:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

61:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

62:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

63:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

64:

biospecimen:Saliva

concentration_value:470 +/- 610

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

65:

biospecimen:Saliva

concentration_value:410 +/- 1000

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

66:

biospecimen:Saliva

concentration_value:16.0 +/- 18.3

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

67:

biospecimen:Saliva

concentration_value:290 +/- 620

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

68:

biospecimen:Saliva

concentration_value:200 +/- 330

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

69:

biospecimen:Saliva

concentration_value:5350 (100-10600)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

70:

biospecimen:Saliva

concentration_value:107.45 +/- 64.52

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

71:

biospecimen:Saliva

concentration_value:1-128

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:normal

72:

biospecimen:Saliva

concentration_value:1-76

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:normal

73:

biospecimen:Saliva

concentration_value:85.38 +/- 94.78

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

74:

biospecimen:Sweat

concentration_value:

concentration_units:

subject_age:Adult

subject_sex:Both

subject_condition:Normal

75:

biospecimen:Urine

concentration_value:0-30

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

76:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

77:

biospecimen:Urine

concentration_value:19.55-89.06

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

78:

biospecimen:Urine

concentration_value:33.86(23.57-47.66)

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Female

subject_condition:Normal

79:

biospecimen:Urine

concentration_value:34.18(19.29-92.98)

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Male

subject_condition:Normal

80:

biospecimen:Urine

concentration_value:9.79 +/- 9.34

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

81:

biospecimen:Urine

concentration_value:2.1 (1.0-3.7)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

82:

biospecimen:Urine

concentration_value:14-28.0

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Male

subject_condition:Normal

83:

biospecimen:Urine

concentration_value:14.0-23.6

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Female

subject_condition:Normal

84:

biospecimen:Urine

concentration_value:16.9-30.6

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Male

subject_condition:Normal

85:

biospecimen:Urine

concentration_value:2.27-79.53

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

86:

biospecimen:Urine

concentration_value:17.3-35.1

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Female

subject_condition:Normal

87:

biospecimen:Urine

concentration_value:4.21 +/- 1.37

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Both

subject_condition:Normal

88:

biospecimen:Urine

concentration_value:8.349 +/- 4.704

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

89:

biospecimen:Urine

concentration_value:1.7985 (0-3.597)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

90:

biospecimen:Urine

concentration_value:5.4 (2.6-7.9)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

91:

biospecimen:Urine

concentration_value:2.7 (0.8-6.4)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

92:

biospecimen:Urine

concentration_value:21.2 (8.8-59.3)

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

93:

biospecimen:Urine

concentration_value:51.865 +/- 15.608

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

94:

biospecimen:Urine

concentration_value:28.6 (12.9-43.0)

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

95:

biospecimen:Urine

concentration_value:12.4 (5.3-22.1)

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Both

subject_condition:Normal

96:

biospecimen:Urine

concentration_value:10.2 (4.7-40.5)

concentration_units:umol/mmol creatinine

subject_age:Adolescent (13-18 years old)

subject_sex:Both

subject_condition:Normal

97:

biospecimen:Urine

concentration_value:38.50 (18.32 – 69.64)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

98:

biospecimen:Urine

concentration_value:2.13 (0.54-8.67)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

99:

biospecimen:Urine

concentration_value:1.68 (0.62-3.30)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

100:

biospecimen:Urine

concentration_value:7

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

101:

biospecimen:Urine

concentration_value:13-41

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

异常浓度
1:

biospecimen:Blood

concentration_value:77.9 (32.4)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Down syndrome pregnancy

2:

biospecimen:Blood

concentration_value:61.0 (26.4)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

3:

biospecimen:Blood

concentration_value:150 (120-170)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Myopathy with lactic acidosis, hereditary

4:

biospecimen:Blood

concentration_value:500

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Female

patient_information:Fructose-1,6-bisphosphatase deficiency

5:

biospecimen:Blood

concentration_value:1090 (650-1520)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Myopathy with lactic acidosis, hereditary

6:

biospecimen:Blood

concentration_value:710

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Myopathy with lactic acidosis, hereditary

7:

biospecimen:Blood

concentration_value:800-900

concentration_units:uM

patient_age:Newborn (0-30 days old)

patient_sex:Female

patient_information:Mitochondrial pyruvate carrier deficiency

8:

biospecimen:Blood

concentration_value:670 +/- 990

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Pyruvate dehydrogenase deficiency (E1)

9:

biospecimen:Blood

concentration_value:560 +/- 830

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Pyruvate dehydrogenase deficiency E1-alpha

10:

biospecimen:Blood

concentration_value:400

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Male

patient_information:Pyruvate dehydrogenase phosphatase deficiency

11:

biospecimen:Blood

concentration_value:50.2 +/- 40

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Heart Transplant

12:

biospecimen:Blood

concentration_value:60-240

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Male

patient_information:2-Ketoglutarate dehydrogenase complex deficiency

13:

biospecimen:Blood

concentration_value:499.647

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Male

patient_information:Leigh Syndrome

14:

biospecimen:Blood

concentration_value:74.66 +/- 35.11

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy with fetuses with trisomy 18

15:

biospecimen:Blood

concentration_value:59.70 +/- 23.3

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

16:

biospecimen:Blood

concentration_value:500

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Male

patient_information:3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency

17:

biospecimen:Blood

concentration_value:89.3 (27.0)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Early preeclampsia

18:

biospecimen:Blood

concentration_value:400-40200

concentration_units:uM

patient_age:Newborn (0-30 days old)

patient_sex:Both

patient_information:3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency

19:

biospecimen:Blood

concentration_value:71.3 (26.7)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

20:

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

21:

biospecimen:Blood

concentration_value:102-230

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:2-Ketoglutarate dehydrogenase complex deficiency

22:

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:gastric cancer

23:

biospecimen:Blood

concentration_value:270

concentration_units:uM

patient_age:Newborn (0-30 days old)

patient_sex:Male

patient_information:2-Ketoglutarate dehydrogenase complex deficiency

24:

biospecimen:Blood

concentration_value:5-440

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:2-Ketoglutarate dehydrogenase complex deficiency

25:

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

26:

biospecimen:Blood

concentration_value:63.92 (19.24)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy with fetus having congenital heart defect

27:

biospecimen:Blood

concentration_value:54.52 (25.5)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

28:

biospecimen:Blood

concentration_value:83.1 (45.8)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Late-onset preeclampsia

29:

biospecimen:Blood

concentration_value:62.1 (24.1)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

30:

biospecimen:Blood

concentration_value:120(80-160)

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Both

patient_information:GRACILE syndrome

31:

biospecimen:Blood

concentration_value:160-320

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Male

patient_information:Dihydrolipoamide Dehydrogenase Deficiency

32:

biospecimen:Blood

concentration_value:440

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Male

patient_information:Lipoyltransferase 1 Deficiency

33:

biospecimen:Blood

concentration_value:93.5 (27.0-160.0)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:3-methylglutaconic aciduria type II, X-linked

34:

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Schizophrenia

35:

biospecimen:Blood

concentration_value:313 +/- 31

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Male

patient_information:Glucagon deficiency

36:

biospecimen:Blood

concentration_value:60

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Male

patient_information:3-Hydroxy-3-Methylglutaryl-CoA Synthase Deficiency

37:

biospecimen:Cellular Cytoplasm

concentration_value:140 (130-150)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Anoxia

38:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:195.0 (175.0-215.0)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Meningitis

39:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:49

concentration_units:uM

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Isolated 3-Methylcrotonyl-CoA Carboxylase Deficiency

40:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:253 - 345

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Male

patient_information:Fumarase deficiency

41:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:570 +/- 400

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Pyruvate dehydrogenase deficiency (E1)

42:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:480 +/- 270

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Pyruvate dehydrogenase deficiency E1-alpha

43:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:176.900-191.400

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:2-Ketoglutarate dehydrogenase complex deficiency

44:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:360

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Male

patient_information:Lipoyltransferase 1 Deficiency

45:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

46:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal Cancer

47:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Irritable Bowel Syndrome

48:

biospecimen:Saliva

concentration_value:149.14 +/- 172.29

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Alzheimer's disease

49:

biospecimen:Saliva

concentration_value:72.05 +/- 29.52

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Frontotemporal lobe dementia

50:

biospecimen:Saliva

concentration_value:138.32 +/- 112.14

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Lewy body disease

51:

biospecimen:Urine

concentration_value:0.2 (0.10-0.30)

concentration_units:umol/mmol creatinine

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:3-Methylglutaconic Aciduria (TYPE II), X-LINKED

52:

biospecimen:Urine

concentration_value:400-1255

concentration_units:umol/mmol creatinine

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Pearson Syndrome

53:

biospecimen:Urine

concentration_value:9.988 +/- 10.859

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Eosinophilic esophagitis

54:

biospecimen:Urine

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

55:

biospecimen:Urine

concentration_value:44.226 +/- 13.63

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Eosinophilic esophagitis

56:

biospecimen:Urine

concentration_value:54.585 +/- 36.553

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Gastroesophageal reflux disease

57:

biospecimen:Urine

concentration_value:45.58 (18.06 – 104.62)

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Type 1 diabetes Mellitus

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reference_text:Leoni V, Masterman T, Mousavi FS, Wretlind B, Wahlund LO, Diczfalusy U, Hillert J, Bjorkhem I: Diagnostic use of cerebral and extracerebral oxysterols. Clin Chem Lab Med. 2004 Feb;42(2):186-91.

pubmed_id:15061359

[7]:

reference_text:Westcott JY, Murphy RC, Stenmark K: Eicosanoids in human ventricular cerebrospinal fluid following severe brain injury. Prostaglandins. 1987 Dec;34(6):877-87.

pubmed_id:2835791

[8]:

reference_text:Silva SO, Ximenes VF, Livramento JA, Catalani LH, Campa A: High concentrations of the melatonin metabolite, N1-acetyl-N2-formyl-5-methoxykynuramine, in cerebrospinal fluid of patients with meningitis: a possible immunomodulatory mechanism. J Pineal Res. 2005 Oct;39(3):302-6.

pubmed_id:16150112

[9]:

reference_text:Rodriguez-Nunez A, Cid E, Rodriguez-Garcia J, Camina F, Rodriguez-Segade S, Castro-Gago M: Neuron-specific enolase, nucleotides, nucleosides, purine bases, oxypurines and uric acid concentrations in cerebrospinal fluid of children with meningitis. Brain Dev. 2003 Mar;25(2):102-6.

pubmed_id:12581805

[10]:

reference_text:Qureshi GA, Baig SM, Bednar I, Halawa A, Parvez SH: The neurochemical markers in cerebrospinal fluid to differentiate between aseptic and tuberculous meningitis. Neurochem Int. 1998 Feb;32(2):197-203.

pubmed_id:9542731

[11]:

reference_text:Laurent UB, Laurent TC, Hellsing LK, Persson L, Hartman M, Lilja K: Hyaluronan in human cerebrospinal fluid. Acta Neurol Scand. 1996 Sep;94(3):194-206.

pubmed_id:8899053

16:

name:Pyruvate dehydrogenase deficiency

omim_id:312170

[1]:

reference_text:Patel KP, O'Brien TW, Subramony SH, Shuster J, Stacpoole PW: The spectrum of pyruvate dehydrogenase complex deficiency: clinical, biochemical and genetic features in 371 patients. Mol Genet Metab. 2012 Jan;105(1):34-43. doi: 10.1016/j.ymgme.2011.09.032. Epub 2011 Oct 7.

pubmed_id:22079328

[2]:

reference_text:OMIM 238331

pubmed_id:

17:

name:Glucagon deficiency

omim_id:

[1]:

reference_text:Vidnes J, Oyasaeter S: Glucagon deficiency causing severe neonatal hypoglycemia in a patient with normal insulin secretion. Pediatr Res. 1977 Sep;11(9 Pt 1):943-9.

pubmed_id:904979

18:

name:3-methylglutaconic aciduria type II, X-linked

omim_id:302060

[1]:

reference_text:Schlame M, Ren M: Barth syndrome, a human disorder of cardiolipin metabolism. FEBS Lett. 2006 Oct 9;580(23):5450-5. Epub 2006 Jul 17.

pubmed_id:16973164

[2]:

reference_text:Kelley RI, Cheatham JP, Clark BJ, Nigro MA, Powell BR, Sherwood GW, Sladky JT, Swisher WP: X-linked dilated cardiomyopathy with neutropenia, growth retardation, and 3-methylglutaconic aciduria. J Pediatr. 1991 Nov;119(5):738-47.

pubmed_id:1719174

[3]:

reference_text:Cantlay AM, Shokrollahi K, Allen JT, Lunt PW, Newbury-Ecob RA, Steward CG: Genetic analysis of the G4.5 gene in families with suspected Barth syndrome. J Pediatr. 1999 Sep;135(3):311-5.

pubmed_id:10484795

[4]:

reference_text:MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de)

pubmed_id:

19:

name:Leigh's syndrome, subacute necrotizing encephalopathy, SNE

omim_id:256000

[1]:

reference_text:Hommes FA, Polman HA, Reerink JD: Leigh's encephalomyelopathy: an inborn error of gluconeogenesis. Arch Dis Child. 1968 Aug;43(230):423-6.

pubmed_id:4873809

[2]:

reference_text:MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de)

pubmed_id:

20:

name:Eosinophilic esophagitis

omim_id:610247

[1]:

reference_text:Mordechai, Hien, and David S. Wishart

pubmed_id:

21:

name:3-Hydroxy-3-Methylglutaryl-CoA Synthase Deficiency

omim_id:605911

[1]:

reference_text:Thompson GN, Hsu BY, Pitt JJ, Treacy E, Stanley CA: Fasting hypoketotic coma in a child with deficiency of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase. N Engl J Med. 1997 Oct 23;337(17):1203-7. doi: 10.1056/NEJM199710233371704.

pubmed_id:9337379

[2]:

reference_text:Morris AA, Lascelles CV, Olpin SE, Lake BD, Leonard JV, Quant PA: Hepatic mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme a synthase deficiency. Pediatr Res. 1998 Sep;44(3):392-6. doi: 10.1203/00006450-199809000-00021.

pubmed_id:9727719

[3]:

reference_text:Conboy E, Vairo F, Schultz M, Agre K, Ridsdale R, Deyle D, Oglesbee D, Gavrilov D, Klee EW, Lanpher B: Mitochondrial 3-Hydroxy-3-Methylglutaryl-CoA Synthase Deficiency: Unique Presenting Laboratory Values and a Review of Biochemical and Clinical Features. JIMD Rep. 2017 Oct 14. doi: 10.1007/8904_2017_59.

pubmed_id:29030856

22:

name:Dihydrolipoamide Dehydrogenase Deficiency

omim_id:246900

[1]:

reference_text:Kuhara T, Shinka T, Inoue Y, Matsumoto M, Yoshino M, Sakaguchi Y, Matsumoto I: Studies of urinary organic acid profiles of a patient with dihydrolipoyl dehydrogenase deficiency. Clin Chim Acta. 1983 Sep 30;133(2):133-40.

pubmed_id:6688766

[2]:

reference_text:Kumps A, Duez P, Mardens Y: Metabolic, nutritional, iatrogenic, and artifactual sources of urinary organic acids: a comprehensive table. Clin Chem. 2002 May;48(5):708-17.

pubmed_id:11978597

23:

name:GRACILE syndrome

omim_id:603358

[1]:

reference_text:Visapaa I, Fellman V, Vesa J, Dasvarma A, Hutton JL, Kumar V, Payne GS, Makarow M, Van Coster R, Taylor RW, Turnbull DM, Suomalainen A, Peltonen L: GRACILE syndrome, a lethal metabolic disorder with iron overload, is caused by a point mutation in BCS1L. Am J Hum Genet. 2002 Oct;71(4):863-76. Epub 2002 Sep 5.

pubmed_id:12215968

24:

name:Lipoyltransferase 1 Deficiency

omim_id:616299

[1]:

reference_text:Soreze Y, Boutron A, Habarou F, Barnerias C, Nonnenmacher L, Delpech H, Mamoune A, Chretien D, Hubert L, Bole-Feysot C, Nitschke P, Correia I, Sardet C, Boddaert N, Hamel Y, Delahodde A, Ottolenghi C, de Lonlay P: Mutations in human lipoyltransferase gene LIPT1 cause a Leigh disease with secondary deficiency for pyruvate and alpha-ketoglutarate dehydrogenase. Orphanet J Rare Dis. 2013 Dec 17;8:192. doi: 10.1186/1750-1172-8-192.

pubmed_id:24341803

25:

name:Mitochondrial pyruvate carrier deficiency

omim_id:614741

[1]:

reference_text:Brivet M, Garcia-Cazorla A, Lyonnet S, Dumez Y, Nassogne MC, Slama A, Boutron A, Touati G, Legrand A, Saudubray JM: Impaired mitochondrial pyruvate importation in a patient and a fetus at risk. Mol Genet Metab. 2003 Mar;78(3):186-92.

pubmed_id:12649063

26:

name:Myopathy with lactic acidosis, hereditary

omim_id:255125

[1]:

reference_text:LARSSON LE, LINDERHOLM H, MUELLER R, RINGQVIST T, SOERNAES R: HEREDITARY METABOLIC MYOPATHY WITH PAROXYSMAL MYOGLOBINURIA DUE TO ABNORMAL GLYCOLYSIS. J Neurol Neurosurg Psychiatry. 1964 Oct;27:361-80.

pubmed_id:14213465

27:

name:Pearson Syndrome

omim_id:557000

[1]:

reference_text:Crippa BL, Leon E, Calhoun A, Lowichik A, Pasquali M, Longo N: Biochemical abnormalities in Pearson syndrome. Am J Med Genet A. 2015 Mar;167A(3):621-8. doi: 10.1002/ajmg.a.36939.

pubmed_id:25691415

28:

name:Pyruvate dehydrogenase deficiency (E1)

omim_id:

[1]:

reference_text:Patel KP, O'Brien TW, Subramony SH, Shuster J, Stacpoole PW: The spectrum of pyruvate dehydrogenase complex deficiency: clinical, biochemical and genetic features in 371 patients. Mol Genet Metab. 2012 Jan;105(1):34-43. doi: 10.1016/j.ymgme.2011.09.032. Epub 2011 Oct 7.

pubmed_id:22079328

29:

name:Pyruvate dehydrogenase phosphatase deficiency

omim_id:608782

[1]:

reference_text:Robinson BH, Sherwood WG: Pyruvate dehydrogenase phosphatase deficiency: a cause of congenital chronic lactic acidosis in infancy. Pediatr Res. 1975 Dec;9(12):935-9. doi: 10.1203/00006450-197512000-00015.

pubmed_id:172850

30:

name:Early preeclampsia

omim_id:

[1]:

reference_text:Bahado-Singh RO, Akolekar R, Mandal R, Dong E, Xia J, Kruger M, Wishart DS, Nicolaides K: Metabolomics and first-trimester prediction of early-onset preeclampsia. J Matern Fetal Neonatal Med. 2012 Oct;25(10):1840-7. doi: 10.3109/14767058.2012.680254. Epub 2012 Apr 28.

pubmed_id:22494326

31:

name:Late-onset preeclampsia

omim_id:

[1]:

reference_text:Bahado-Singh RO, Akolekar R, Mandal R, Dong E, Xia J, Kruger M, Wishart DS, Nicolaides K: First-trimester metabolomic detection of late-onset preeclampsia. Am J Obstet Gynecol. 2013 Jan;208(1):58.e1-7. doi: 10.1016/j.ajog.2012.11.003. Epub 2012 Nov 13.

pubmed_id:23159745

32:

name:Lewy body disease

omim_id:

[1]:

reference_text:Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6.

pubmed_id:23857558

KEGG数据库编号
C00022
DrugBank数据库编号
DB00119
foodb数据库编号
FDB031141
ChemSpider数据库编号
公共化学化合物编号
1060
PDB数据库编号
生物利益的化学实体数据库编号
32816
knapsack数据库编号
C00001200
维基百科编号
Pyruvic_acid
代谢途径的数据库编号
PYRUVATE
苯酚资源管理器化合物数据库编号
比格数据库编号
梅林编号
虚拟机身份证编号
PYR
fbonto数据库编号
综合参考
Xiang, Wei; Okita, Motomu. Preparation of pyruvic acid. Jpn. Kokai Tokkyo Koho (2003), 5 pp.
一般参考
1:

protein_accession:HMDBP00012

name:Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

uniprot_id:P11177

gene_name:PDHB

protein_type:Enzyme

2:

protein_accession:HMDBP00019

name:Pyruvate carboxylase, mitochondrial

uniprot_id:P11498

gene_name:PC

protein_type:Unknown

3:

protein_accession:HMDBP00046

name:Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

uniprot_id:P08559

gene_name:PDHA1

protein_type:Enzyme

4:

protein_accession:HMDBP00050

name:Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial

uniprot_id:P29803

gene_name:PDHA2

protein_type:Enzyme

5:

protein_accession:HMDBP00054

name:Dihydrolipoyl dehydrogenase, mitochondrial

uniprot_id:P09622

gene_name:DLD

protein_type:Unknown

6:

protein_accession:HMDBP00055

name:Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

uniprot_id:P10515

gene_name:DLAT

protein_type:Enzyme

7:

protein_accession:HMDBP00206

name:D-amino-acid oxidase

uniprot_id:P14920

gene_name:DAO

protein_type:Unknown

8:

protein_accession:HMDBP00248

name:4-aminobutyrate aminotransferase, mitochondrial

uniprot_id:P80404

gene_name:ABAT

protein_type:Enzyme

9:

protein_accession:HMDBP00396

name:Alanine--glyoxylate aminotransferase 2, mitochondrial

uniprot_id:Q9BYV1

gene_name:AGXT2

protein_type:Enzyme

10:

protein_accession:HMDBP00420

name:S-adenosylmethionine decarboxylase proenzyme

uniprot_id:P17707

gene_name:AMD1

protein_type:Unknown

11:

protein_accession:HMDBP00464

name:Kynurenine--oxoglutarate transaminase 1

uniprot_id:Q16773

gene_name:CCBL1

protein_type:Enzyme

12:

protein_accession:HMDBP00538

name:Cystathionine gamma-lyase

uniprot_id:P32929

gene_name:CTH

protein_type:Enzyme

13:

protein_accession:HMDBP00671

name:L-serine dehydratase/L-threonine deaminase

uniprot_id:P20132

gene_name:SDS

protein_type:Enzyme

14:

protein_accession:HMDBP00704

name:Adenylate cyclase type 7

uniprot_id:P51828

gene_name:ADCY7

protein_type:Unknown

15:

protein_accession:HMDBP00705

name:Adenylate cyclase type 4

uniprot_id:Q8NFM4

gene_name:ADCY4

protein_type:Unknown

16:

protein_accession:HMDBP00706

name:Adenylate cyclase type 6

uniprot_id:O43306

gene_name:ADCY6

protein_type:Unknown

17:

protein_accession:HMDBP00707

name:Adenylate cyclase type 5

uniprot_id:O95622

gene_name:ADCY5

protein_type:Unknown

18:

protein_accession:HMDBP00708

name:Adenylate cyclase type 8

uniprot_id:P40145

gene_name:ADCY8

protein_type:Unknown

19:

protein_accession:HMDBP00709

name:Adenylate cyclase type 9

uniprot_id:O60503

gene_name:ADCY9

protein_type:Unknown

20:

protein_accession:HMDBP00710

name:Adenylate cyclase type 3

uniprot_id:O60266

gene_name:ADCY3

protein_type:Unknown

21:

protein_accession:HMDBP00711

name:Adenylate cyclase type 1

uniprot_id:Q08828

gene_name:ADCY1

protein_type:Unknown

22:

protein_accession:HMDBP00763

name:Pyruvate kinase isozymes M1/M2

uniprot_id:P14618

gene_name:PKM

protein_type:Unknown

23:

protein_accession:HMDBP00765

name:Pyruvate kinase isozymes R/L

uniprot_id:P30613

gene_name:PKLR

protein_type:Unknown

24:

protein_accession:HMDBP00781

name:3-mercaptopyruvate sulfurtransferase

uniprot_id:P25325

gene_name:MPST

protein_type:Enzyme

25:

protein_accession:HMDBP00789

name:Serine--pyruvate aminotransferase

uniprot_id:P21549

gene_name:AGXT

protein_type:Unknown

26:

protein_accession:HMDBP00850

name:Alanine aminotransferase 1

uniprot_id:P24298

gene_name:GPT

protein_type:Enzyme

27:

protein_accession:HMDBP00857

name:NADP-dependent malic enzyme

uniprot_id:P48163

gene_name:ME1

protein_type:Unknown

28:

protein_accession:HMDBP00859

name:NADP-dependent malic enzyme, mitochondrial

uniprot_id:Q16798

gene_name:ME3

protein_type:Unknown

29:

protein_accession:HMDBP00862

name:NAD-dependent malic enzyme, mitochondrial

uniprot_id:P23368

gene_name:ME2

protein_type:Unknown

30:

protein_accession:HMDBP00885

name:Histidine decarboxylase

uniprot_id:P19113

gene_name:HDC

protein_type:Enzyme

31:

protein_accession:HMDBP00893

name:L-lactate dehydrogenase A-like 6A

uniprot_id:Q6ZMR3

gene_name:LDHAL6A

protein_type:Unknown

32:

protein_accession:HMDBP00921

name:Adenylate cyclase type 2

uniprot_id:Q08462

gene_name:ADCY2

protein_type:Unknown

33:

protein_accession:HMDBP01056

name:Thiosulfate sulfurtransferase

uniprot_id:Q16762

gene_name:TST

protein_type:Unknown

34:

protein_accession:HMDBP01108

name:Monocarboxylate transporter 3

uniprot_id:O95907

gene_name:SLC16A8

protein_type:Enzyme

35:

protein_accession:HMDBP01109

name:Monocarboxylate transporter 4

uniprot_id:O15427

gene_name:SLC16A3

protein_type:Transporter

36:

protein_accession:HMDBP01110

name:Monocarboxylate transporter 7

uniprot_id:O15403

gene_name:SLC16A6

protein_type:Enzyme

37:

protein_accession:HMDBP01111

name:Monocarboxylate transporter 1

uniprot_id:P53985

gene_name:SLC16A1

protein_type:Transporter

38:

protein_accession:HMDBP01112

name:Monocarboxylate transporter 8

uniprot_id:P36021

gene_name:SLC16A2

protein_type:Transporter

39:

protein_accession:HMDBP01113

name:Monocarboxylate transporter 6

uniprot_id:O15375

gene_name:SLC16A5

protein_type:Enzyme

40:

protein_accession:HMDBP01114

name:Monocarboxylate transporter 5

uniprot_id:O15374

gene_name:SLC16A4

protein_type:Enzyme

41:

protein_accession:HMDBP01115

name:Monocarboxylate transporter 2

uniprot_id:O60669

gene_name:SLC16A7

protein_type:Transporter

42:

protein_accession:HMDBP02255

name:Phosphatidylserine decarboxylase proenzyme

uniprot_id:Q9UG56

gene_name:PISD

protein_type:Enzyme

43:

protein_accession:HMDBP03577

name:L-lactate dehydrogenase B chain

uniprot_id:P07195

gene_name:LDHB

protein_type:Unknown

44:

protein_accession:HMDBP03578

name:L-lactate dehydrogenase C chain

uniprot_id:P07864

gene_name:LDHC

protein_type:Unknown

45:

protein_accession:HMDBP03579

name:L-lactate dehydrogenase A chain

uniprot_id:P00338

gene_name:LDHA

protein_type:Unknown

46:

protein_accession:HMDBP03581

name:L-lactate dehydrogenase A-like 6B

uniprot_id:Q9BYZ2

gene_name:LDHAL6B

protein_type:Unknown

47:

protein_accession:HMDBP03582

name:Probable D-lactate dehydrogenase, mitochondrial

uniprot_id:Q86WU2

gene_name:LDHD

protein_type:Unknown

48:

protein_accession:HMDBP03670

name:Alanine aminotransferase 2

uniprot_id:Q8TD30

gene_name:GPT2

protein_type:Enzyme

49:

protein_accession:HMDBP04824

name:Selenocysteine lyase

uniprot_id:Q96I15

gene_name:SCLY

protein_type:Enzyme

50:

protein_accession:HMDBP05340

name:Monocarboxylate transporter 10

uniprot_id:Q8TF71

gene_name:SLC16A10

protein_type:Transporter

51:

protein_accession:HMDBP05558

name:Solute carrier organic anion transporter family member 2A1

uniprot_id:Q92959

gene_name:SLCO2A1

protein_type:Transporter

52:

protein_accession:HMDBP07357

name:N-acetylneuraminate lyase

uniprot_id:Q9BXD5

gene_name:NPL

protein_type:Enzyme

53:

protein_accession:HMDBP07364

name:Acetolactate synthase-like protein

uniprot_id:A1L0T0

gene_name:ILVBL

protein_type:Unknown

54:

protein_accession:HMDBP07411

name:Malic enzyme

uniprot_id:Q8TBJ0

gene_name:ME3

protein_type:Enzyme

55:

protein_accession:HMDBP07677

name:Acylpyruvase FAHD1, mitochondrial

uniprot_id:Q6P587

gene_name:FAHD1

protein_type:Unknown

56:

protein_accession:HMDBP08968

name:Kynurenine--oxoglutarate transaminase 3

uniprot_id:Q6YP21

gene_name:CCBL2

protein_type:Enzyme

57:

protein_accession:HMDBP08972

name:Serine dehydratase-like

uniprot_id:Q96GA7

gene_name:SDSL

protein_type:Enzyme

58:

protein_accession:HMDBP08975

name:Serine racemase

uniprot_id:Q9GZT4

gene_name:SRR

protein_type:Enzyme

59:

protein_accession:HMDBP11784

name:Probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial

uniprot_id:Q86XE5

gene_name:HOGA1

protein_type:Unknown

蛋白质结合
1:

reference_text:Tsuchiya H, Hashizume I, Tokunaga T, Tatsumi M, Takagi N, Hayashi T: High-performance liquid chromatography of alpha-keto acids in human saliva. Arch Oral Biol. 1983;28(11):989-92.

pubmed_id:6581765

2:

reference_text:Guneral F, Bachmann C: Age-related reference values for urinary organic acids in a healthy Turkish pediatric population. Clin Chem. 1994 Jun;40(6):862-6.

pubmed_id:8087979

3:

reference_text:Hoffmann GF, Meier-Augenstein W, Stockler S, Surtees R, Rating D, Nyhan WL: Physiology and pathophysiology of organic acids in cerebrospinal fluid. J Inherit Metab Dis. 1993;16(4):648-69.

pubmed_id:8412012

4:

reference_text:Silwood CJ, Lynch E, Claxson AW, Grootveld MC: 1H and (13)C NMR spectroscopic analysis of human saliva. J Dent Res. 2002 Jun;81(6):422-7.

pubmed_id:12097436

5:

reference_text:Subramanian A, Gupta A, Saxena S, Gupta A, Kumar R, Nigam A, Kumar R, Mandal SK, Roy R: Proton MR CSF analysis and a new software as predictors for the differentiation of meningitis in children. NMR Biomed. 2005 Jun;18(4):213-25.

pubmed_id:15627241

6:

reference_text:Nakayama Y, Kinoshita A, Tomita M: Dynamic simulation of red blood cell metabolism and its application to the analysis of a pathological condition. Theor Biol Med Model. 2005 May 9;2:18.

pubmed_id:15882454

7:

reference_text:Zupke C, Sinskey AJ, Stephanopoulos G: Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas. Appl Microbiol Biotechnol. 1995 Dec;44(1-2):27-36.

pubmed_id:8579834

8:

reference_text:Foster KJ, Alberti KG, Hinks L, Lloyd B, Postle A, Smythe P, Turnell DC, Walton R: Blood intermediary metabolite and insulin concentrations after an overnight fast: reference ranges for adults, and interrelations. Clin Chem. 1978 Sep;24(9):1568-72.

pubmed_id:688619

9:

reference_text:Nielsen J, Ytrebo LM, Borud O: Lactate and pyruvate concentrations in capillary blood from newborns. Acta Paediatr. 1994 Sep;83(9):920-2.

pubmed_id:7819686

10:

reference_text:Ka T, Yamamoto T, Moriwaki Y, Kaya M, Tsujita J, Takahashi S, Tsutsumi Z, Fukuchi M, Hada T: Effect of exercise and beer on the plasma concentration and urinary excretion of purine bases. J Rheumatol. 2003 May;30(5):1036-42.

pubmed_id:12734903

11:

reference_text:Talseth T, Haegele KD, McNay JL, Skrdlant HB, Clementi WA, Shepherd AM: Pharmacokinetics and cardiovascular effects in rabbits of a major hydralazine metabolite, the hydralazine pyruvic-acid hydrazone. J Pharmacol Exp Ther. 1979 Dec;211(3):509-13.

pubmed_id:512915

12:

reference_text:Reece PA, Cozamanis I, Zacest R: Selective high-performance liquid chromatographic assays for hydralazine and its metabolites in plasma of man. J Chromatogr. 1980 Mar 14;181(3-4):427-40.

pubmed_id:7391156

13:

reference_text:Meijer-Severs GJ, Van Santen E, Meijer BC: Short-chain fatty acid and organic acid concentrations in feces of healthy human volunteers and their correlations with anaerobe cultural counts during systemic ceftriaxone administration. Scand J Gastroenterol. 1990 Jul;25(7):698-704.

pubmed_id:2396083

14:

reference_text:Elling D, Bader K: [Biochemical changes in cervix mucus in stepwise malignant transformation of cervix epithelium]. Zentralbl Gynakol. 1990;112(9):555-60.

pubmed_id:2378186

15:

reference_text:Mongan PD, Capacchione J, West S, Karaian J, Dubois D, Keneally R, Sharma P: Pyruvate improves redox status and decreases indicators of hepatic apoptosis during hemorrhagic shock in swine. Am J Physiol Heart Circ Physiol. 2002 Oct;283(4):H1634-44. Epub 2002 Jun 20.

pubmed_id:12234818

16:

reference_text:Wendisch VF: Microbial Production of Amino Acid-Related Compounds. Adv Biochem Eng Biotechnol. 2017;159:255-269. doi: 10.1007/10_2016_34.

pubmed_id:27872963

17:

reference_text:Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043.

pubmed_id:32033212

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