创建日期
2005-11-16 15:48:42 UTC
更新日期
2021-09-14 15:46:02 UTC
二级访问
HMDB0000533
HMDB0014288
HMDB00215
HMDB00533
HMDB14288
名称
N-Acetyl-D-glucosamine
描述
N-Acetyl-D-Glucosamine (N-acetlyglucosamine) is a monosaccharide derivative of glucose. Chemically it is an amide between glucosamine and acetic acid. A single N-acetlyglucosamine moiety linked to serine or threonine residues on nuclear and cytoplasmic proteins -O-GlcNAc, is an ubiquitous post-translational protein modification. O-GlcNAc modified proteins are involved in sensing the nutrient status of the surrounding cellular environment and adjusting the activity of cellular proteins accordingly. O-GlcNAc regulates cellular responses to hormones such as insulin, initiates a protective response to stress, modulates a cell's capacity to grow and divide, and regulates gene transcription. In humans, it exists in skin, cartilage and blood vessel as a component of hyaluronic acid, and bone tissue, cornea and aorta as a component of keratan sulfate. (PMID 16237703).
同义词
1:2-Acetamido-2-deoxy-D-glucose
2:GlcNAc
3:N-Acetylchitosamine
4:2-(Acetylamino)-2-deoxyhexose
5:2-Acetamido-2-deoxy-D-glucopyranose
6:2-Acetamido-2-deoxyglucose
7:2-Acetamido-D-glucose
8:2-Acetylamino-2-deoxy-D-glucose
9:Acetylglucosamine
10:N-Acetylglucosamine
11:N-[(3R,4R,5S,6R)-2,4,5-Trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide
12:2 Acetamido 2 deoxyglucose
13:N Acetyl D glucosamine
14:2 Acetamido 2 deoxy D glucose
化学名称
N-[(3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide
代谢物结构字符串
CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O
inchi标识符
InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8?/m1/s1
印记键
OVRNDRQMDRJTHS-RTRLPJTCSA-N
分类学
description: belongs to the class of organic compounds known as acylaminosugars. These are organic compounds containing a sugar linked to a chain through N-acyl group.
description:Acylaminosugars
kingdom:Organic compounds
super_class:Organic oxygen compounds
class:Organooxygen compounds
sub_class:Carbohydrates and carbohydrate conjugates
molecular_framework:Aliphatic heteromonocyclic compounds
1:Acetamides
2:Carbonyl compounds
3:Hemiacetals
4:Hexoses
5:Hydrocarbon derivatives
6:N-acyl-alpha-hexosamines
7:Organic oxides
8:Organonitrogen compounds
9:Organopnictogen compounds
10:Oxacyclic compounds
11:Oxanes
12:Polyols
13:Primary alcohols
14:Secondary alcohols
15:Secondary carboxylic acid amides
16:Acetamide
17:Acylaminosugar
18:Alcohol
19:Aliphatic heteromonocyclic compound
20:Carbonyl group
21:Carboxamide group
22:Carboxylic acid derivative
23:Hemiacetal
24:Hexose monosaccharide
25:Hydrocarbon derivative
26:Monosaccharide
27:N-acyl-alpha-hexosamine
28:Organic nitrogen compound
29:Organic oxide
30:Organoheterocyclic compound
31:Organonitrogen compound
32:Organopnictogen compound
33:Oxacycle
34:Oxane
35:Polyol
36:Primary alcohol
37:Secondary alcohol
38:Secondary carboxylic acid amide
39:Amino sugars
40:N-acetylglucosamine
本体论
term:Disposition
definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.
parent_id:
level:1
type:parent
term:Route of exposure
definition:A mean by which a chemical agent comes in contact with an organism, either under intended or unintended circumstances.
parent_id:7724
*level:2
type:parent
term:Enteral
definition:Chemical exposure via the alimentary canal (mouth to anus).
parent_id:7743
**level:3
type:parent
term:Ingestion
definition:Chemical exposure facilitated by entry through the mouth.
parent_id:7744
***level:4
type:child
synonym:Digestion
term:Source
definition:Natural or synthetic origin of a chemical.
parent_id:7724
*level:2
type:parent
term:Endogenous
definition:
parent_id:7735
**level:3
type:child
term:Food
definition:
parent_id:7735
**level:3
type:child
term:Biological
definition:A living organism (species or a higher taxonomy rank), in which a chemical can be found.
parent_id:7735
**level:3
type:parent
term:Plant
definition:A living organism belonging to the kingdom plantea. typically, it grows in a permanent site, absorbs water and inorganic substances through its roots, and synthesizes nutrients in its leaves by photosynthesis using the green pigment chlorophyll. examples incude trees, shrubs, herbs, grasses, ferns, and mosses.
parent_id:7736
***level:4
type:child
synonym:Flora
term:Biological location
definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.
parent_id:7724
*level:2
type:parent
term:Tissue and substructures
definition:An anatomical organizational level including multiple cells yet not comprising a complete organ .
parent_id:7725
**level:3
type:parent
term:Placenta
definition:An organ present in some vertebrates during embryonic gestation that surrounds the fetus and provides it with nutrients and oxygen, facilitates gas and waste exchange between the fetus and mother, and provides parasitic cloaking from the mother's immune system by excretion of neurokinin b. (nci).
parent_id:7729
***level:4
type:child
term:Cell and elements
definition:An anatomical organizational level comprising of a single cell (or a fragment in some exceptions). a cell is defined by its type or function. it is the smallest unit of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid.
parent_id:7725
**level:3
type:parent
term:Element
definition:
parent_id:7732
***level:4
type:parent
term:Organ and components
definition:An anatomical organizational level including multiple tissues or substructures, which enables a common biological function.
parent_id:7725
**level:3
type:parent
term:Prostate
definition:The male reproductive accessory gland that produces prostatic fluid and is located adjacent to or around the urethra distal to the urinary bladder in mammals. (nci).
parent_id:7727
***level:4
type:child
synonym:Prostate gland
term:Intestine
definition:The portion of the gastrointestinal tract that includes the small and large intestines.
parent_id:7727
***level:4
type:child
term:Biofluid and excreta
definition:A liquid, semi-solid or solid material originating in the body.
parent_id:7725
**level:3
type:parent
term:Saliva
definition:The watery fluid in the mouth made by the salivary glands. saliva moistens food to help digestion and it helps protect the mouth against infections. (nci).
parent_id:7731
***level:4
type:child
term:Feces
definition:The material discharged from the bowel during defecation. It consists of undigested food, intestinal mucus, epithelial cells, and bacteria.
parent_id:7731
***level:4
type:child
synonym:Fecal
synonym:Stool
synonym:Faecal
synonym:Faeces
term:Urine
definition:Excretion in liquid state processed by the kidney.
parent_id:7731
***level:4
type:child
term:Blood
definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.
parent_id:7731
***level:4
type:child
term:Breast milk
definition:Portion of secreted substance produced by the mammary gland.
parent_id:7731
***level:4
type:child
term:Subcellular
definition:An anatomical organizational level including a component within a biological cell .
parent_id:7725
**level:3
type:parent
term:Cytoplasm
definition:The portion of the cell contained within the plasma membrane but excluding the nucleus.
parent_id:7730
***level:4
type:child
synonym:Cytoplasma
term:Membrane
definition:
parent_id:7730
***level:4
type:child
term:Lysosome
definition:В A sac-like compartment inside a cell that has enzymes that can break down cellular components that need to be destroyed. (NCI).
parent_id:7730
***level:4
type:child
term:Myelin sheath
definition:A layer of phospholipids and protein found on neuronal axons. this structure acts as an electrical insulator that allows nerve impulses to travel faster by increasing the resistance and decreasing the capacitance over that found in unmyelinated nerve fibers. (nci).
parent_id:7730
***level:4
type:child
synonym:Myelin
term:Cell membrane
definition:A cellular compartment that separates a cellВ interiorВ from its exterior.
parent_id:7730
***level:4
type:child
synonym:Cellular membrane
term:Process
definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.
parent_id:
level:1
type:parent
term:Naturally occurring process
definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.
parent_id:7659
*level:2
type:parent
term:Biological process
definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.
parent_id:7660
**level:3
type:parent
term:Biochemical pathway
definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.
parent_id:7661
***level:4
type:parent
term:Role
definition:The purpose or function assumed by a chemical, either naturally or as intended by humans .
parent_id:
level:1
type:parent
term:Industrial application
definition:The assumed function of a chemical utilized by human.
parent_id:7671
*level:2
type:parent
term:Drug
definition:A chemical substance or preparation that causes a physiological effect in the body upon exposure .
parent_id:7678
**level:3
type:child
term:Food and nutrition
definition:A chemical purpose related to manufacturing of food and nutrition products.
parent_id:7678
**level:3
type:parent
term:Nutritional supplement
definition:
parent_id:7687
***level:4
type:child
synonym:Nutraceutical
synonym:Dietary supplement
实验性质
1:
kind:water_solubility
value:167 mg/mL
source:
2:
kind:logp
value:-2.1
source:
3:
kind:melting_point
value:210 °C
source:
预测性质
1:
kind:logp
value:-2.60
source:ALOGPS
2:
kind:logs
value:0.06
source:ALOGPS
3:
kind:solubility
value:254 g/L
source:ALOGPS
4:
kind:logp
value:-3.2
source:ChemAxon
5:
kind:pka_strongest_acidic
value:11.6
source:ChemAxon
6:
kind:pka_strongest_basic
value:-0.78
source:ChemAxon
7:
kind:iupac
value:N-[(3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide
source:ChemAxon
8:
kind:average_mass
value:221.2078
source:ChemAxon
9:
kind:mono_mass
value:221.089937217
source:ChemAxon
10:
kind:smiles
value:CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O
source:ChemAxon
11:
kind:formula
value:C8H15NO6
source:ChemAxon
12:
kind:inchi
value:InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8?/m1/s1
source:ChemAxon
13:
kind:inchikey
value:OVRNDRQMDRJTHS-RTRLPJTCSA-N
source:ChemAxon
14:
kind:polar_surface_area
value:119.25
source:ChemAxon
15:
kind:refractivity
value:47.02
source:ChemAxon
16:
kind:polarizability
value:20.56
source:ChemAxon
17:
kind:rotatable_bond_count
value:2
source:ChemAxon
18:
kind:acceptor_count
value:6
source:ChemAxon
19:
kind:donor_count
value:5
source:ChemAxon
20:
kind:physiological_charge
value:0
source:ChemAxon
21:
kind:formal_charge
value:0
source:ChemAxon
22:
kind:number_of_rings
value:1
source:ChemAxon
23:
kind:bioavailability
value:Yes
source:ChemAxon
24:
kind:rule_of_five
value:Yes
source:ChemAxon
25:
kind:ghose_filter
value:No
source:ChemAxon
26:
kind:veber_rule
value:No
source:ChemAxon
27:
kind:mddr_like_rule
value:No
source:ChemAxon
1:
type:Specdb::NmrOneD
spectrum_id:142950
2:
type:Specdb::NmrOneD
spectrum_id:142951
3:
type:Specdb::NmrOneD
spectrum_id:142952
4:
type:Specdb::NmrOneD
spectrum_id:142953
5:
type:Specdb::NmrOneD
spectrum_id:142954
6:
type:Specdb::NmrOneD
spectrum_id:142955
7:
type:Specdb::NmrOneD
spectrum_id:142956
8:
type:Specdb::NmrOneD
spectrum_id:142957
9:
type:Specdb::NmrOneD
spectrum_id:142958
10:
type:Specdb::NmrOneD
spectrum_id:142959
11:
type:Specdb::NmrOneD
spectrum_id:142960
12:
type:Specdb::NmrOneD
spectrum_id:142961
13:
type:Specdb::NmrOneD
spectrum_id:142962
14:
type:Specdb::NmrOneD
spectrum_id:142963
15:
type:Specdb::NmrOneD
spectrum_id:142964
16:
type:Specdb::NmrOneD
spectrum_id:142965
17:
type:Specdb::NmrOneD
spectrum_id:142966
18:
type:Specdb::NmrOneD
spectrum_id:142967
19:
type:Specdb::NmrOneD
spectrum_id:142968
20:
type:Specdb::NmrOneD
spectrum_id:142969
21:
type:Specdb::CMs
spectrum_id:22568
22:
type:Specdb::CMs
spectrum_id:30389
23:
type:Specdb::CMs
spectrum_id:30630
24:
type:Specdb::CMs
spectrum_id:30631
25:
type:Specdb::CMs
spectrum_id:30887
26:
type:Specdb::CMs
spectrum_id:30888
27:
type:Specdb::CMs
spectrum_id:30889
28:
type:Specdb::CMs
spectrum_id:37364
29:
type:Specdb::CMs
spectrum_id:99541
30:
type:Specdb::CMs
spectrum_id:99542
31:
type:Specdb::CMs
spectrum_id:99543
32:
type:Specdb::CMs
spectrum_id:99544
33:
type:Specdb::CMs
spectrum_id:99545
34:
type:Specdb::CMs
spectrum_id:99546
35:
type:Specdb::CMs
spectrum_id:146682
36:
type:Specdb::MsMs
spectrum_id:23636
37:
type:Specdb::MsMs
spectrum_id:23637
38:
type:Specdb::MsMs
spectrum_id:23638
39:
type:Specdb::MsMs
spectrum_id:30434
40:
type:Specdb::MsMs
spectrum_id:30435
41:
type:Specdb::MsMs
spectrum_id:30436
42:
type:Specdb::MsMs
spectrum_id:2240252
43:
type:Specdb::MsMs
spectrum_id:2241435
44:
type:Specdb::MsMs
spectrum_id:2244441
45:
type:Specdb::MsMs
spectrum_id:2245680
46:
type:Specdb::MsMs
spectrum_id:2246179
47:
type:Specdb::MsMs
spectrum_id:2246516
48:
type:Specdb::MsMs
spectrum_id:2247756
49:
type:Specdb::MsMs
spectrum_id:2248127
50:
type:Specdb::MsMs
spectrum_id:2248638
51:
type:Specdb::MsMs
spectrum_id:2249752
52:
type:Specdb::MsMs
spectrum_id:2250679
53:
type:Specdb::MsMs
spectrum_id:2251710
54:
type:Specdb::MsMs
spectrum_id:2792543
55:
type:Specdb::MsMs
spectrum_id:2792544
56:
type:Specdb::MsMs
spectrum_id:2792545
57:
type:Specdb::MsMs
spectrum_id:2915942
58:
type:Specdb::MsMs
spectrum_id:2915943
59:
type:Specdb::MsMs
spectrum_id:2915944
生物学性质
1:
cellular:(1):Cytoplasm
cellular:(2):Lysosome
cellular:(3):Membrane
2:
biospecimen:(1):Blood
biospecimen:(2):Breast Milk
biospecimen:(3):Feces
biospecimen:(4):Saliva
biospecimen:(5):Urine
3:
tissue:(1):Intestine
tissue:(2):Neuron
tissue:(3):Placenta
tissue:(4):Platelet
tissue:(5):Prostate
4:
[1]:
name:Amino Sugar Metabolism
smpdb_id:SMP00045
kegg_map_id:map00520
[2]:
name:G(M2)-Gangliosidosis: Variant B, Tay-sachs disease
smpdb_id:SMP00534
kegg_map_id:
[3]:
name:Salla Disease/Infantile Sialic Acid Storage Disease
smpdb_id:SMP00240
kegg_map_id:
[4]:
name:Sialuria or French Type Sialuria
smpdb_id:SMP00216
kegg_map_id:
[5]:
name:Tay-Sachs Disease
smpdb_id:SMP00390
kegg_map_id:
正常浓度
1:
biospecimen:Blood
concentration_value:
concentration_units:
subject_age:
subject_sex:
subject_condition:Normal
2:
biospecimen:Breast Milk
concentration_value:204.3278984
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Female
subject_condition:Normal
3:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
4:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Infant (0-1 year old)
subject_sex:Both
subject_condition:Normal
5:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
6:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
7:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Not Specified
subject_condition:Normal
8:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Not Specified
subject_sex:Not Specified
subject_condition:Normal
9:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
10:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
11:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
12:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
13:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
14:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
15:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
16:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
17:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
18:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
19:
biospecimen:Saliva
concentration_value:2.23 +/- 1.83
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
20:
biospecimen:Saliva
concentration_value:2.40 +/- 2.35
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Female
subject_condition:Normal
21:
biospecimen:Saliva
concentration_value:21.4 +/- 18.6
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
22:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
23:
biospecimen:Saliva
concentration_value:3.14 +/- 2.38
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Female
subject_condition:Normal
24:
biospecimen:Saliva
concentration_value:3.78 +/- 3.93
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
25:
biospecimen:Saliva
concentration_value:4.41 +/- 5.98
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Female
subject_condition:Normal
26:
biospecimen:Urine
concentration_value:2.96 +/- 1.85
concentration_units:umol/mmol creatinine
subject_age:Adult (>18 years old)
subject_sex:Not Specified
subject_condition:Normal
异常浓度
1:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Colorectal Cancer
2:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Not Specified
patient_information:asymptomatic diverticulosis
3:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Not Specified
patient_information:symptomatic uncomplicated diverticular disease
4:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Colorectal cancer
5:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Colorectal cancer
6:
biospecimen:Urine
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Bladder cancer
疾病参考
1:
name:Colorectal cancer
omim_id:114500
[1]:
reference_text:Ishiwata S, Itoh K, Yamaguchi T, Ishida N, Mizugaki M: Comparison of serum and urinary levels of modified nucleoside, 1-methyladenosine, in cancer patients using a monoclonal antibody-based inhibition ELISA. Tohoku J Exp Med. 1995 May;176(1):61-8.
pubmed_id:7482520
[2]:
reference_text:Monleon D, Morales JM, Barrasa A, Lopez JA, Vazquez C, Celda B: Metabolite profiling of fecal water extracts from human colorectal cancer. NMR Biomed. 2009 Apr;22(3):342-8. doi: 10.1002/nbm.1345.
pubmed_id:19006102
[3]:
reference_text:Weir TL, Manter DK, Sheflin AM, Barnett BA, Heuberger AL, Ryan EP: Stool microbiome and metabolome differences between colorectal cancer patients and healthy adults. PLoS One. 2013 Aug 6;8(8):e70803. doi: 10.1371/journal.pone.0070803. Print 2013.
pubmed_id:23940645
[4]:
reference_text:Phua LC, Chue XP, Koh PK, Cheah PY, Ho HK, Chan EC: Non-invasive fecal metabonomic detection of colorectal cancer. Cancer Biol Ther. 2014 Apr;15(4):389-97. doi: 10.4161/cbt.27625. Epub 2014 Jan 14.
pubmed_id:24424155
[5]:
reference_text:Ritchie SA, Ahiahonu PW, Jayasinghe D, Heath D, Liu J, Lu Y, Jin W, Kavianpour A, Yamazaki Y, Khan AM, Hossain M, Su-Myat KK, Wood PL, Krenitsky K, Takemasa I, Miyake M, Sekimoto M, Monden M, Matsubara H, Nomura F, Goodenowe DB: Reduced levels of hydroxylated, polyunsaturated ultra long-chain fatty acids in the serum of colorectal cancer patients: implications for early screening and detection. BMC Med. 2010 Feb 15;8:13. doi: 10.1186/1741-7015-8-13.
pubmed_id:20156336
[6]:
reference_text:Qiu Y, Cai G, Su M, Chen T, Zheng X, Xu Y, Ni Y, Zhao A, Xu LX, Cai S, Jia W: Serum metabolite profiling of human colorectal cancer using GC-TOFMS and UPLC-QTOFMS. J Proteome Res. 2009 Oct;8(10):4844-50. doi: 10.1021/pr9004162.
pubmed_id:19678709
[7]:
reference_text:Cheng Y, Xie G, Chen T, Qiu Y, Zou X, Zheng M, Tan B, Feng B, Dong T, He P, Zhao L, Zhao A, Xu LX, Zhang Y, Jia W: Distinct urinary metabolic profile of human colorectal cancer. J Proteome Res. 2012 Feb 3;11(2):1354-63. doi: 10.1021/pr201001a. Epub 2011 Dec 28.
pubmed_id:22148915
[8]:
reference_text:Ni Y, Xie G, Jia W: Metabonomics of human colorectal cancer: new approaches for early diagnosis and biomarker discovery. J Proteome Res. 2014 Sep 5;13(9):3857-70. doi: 10.1021/pr500443c. Epub 2014 Aug 14.
pubmed_id:25105552
[9]:
reference_text:Ikeda A, Nishiumi S, Shinohara M, Yoshie T, Hatano N, Okuno T, Bamba T, Fukusaki E, Takenawa T, Azuma T, Yoshida M: Serum metabolomics as a novel diagnostic approach for gastrointestinal cancer. Biomed Chromatogr. 2012 May;26(5):548-58. doi: 10.1002/bmc.1671. Epub 2011 Jul 20.
pubmed_id:21773981
[10]:
reference_text:Goedert JJ, Sampson JN, Moore SC, Xiao Q, Xiong X, Hayes RB, Ahn J, Shi J, Sinha R: Fecal metabolomics: assay performance and association with colorectal cancer. Carcinogenesis. 2014 Sep;35(9):2089-96. doi: 10.1093/carcin/bgu131. Epub 2014 Jul 18.
pubmed_id:25037050
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reference_text:Sinha R, Ahn J, Sampson JN, Shi J, Yu G, Xiong X, Hayes RB, Goedert JJ: Fecal Microbiota, Fecal Metabolome, and Colorectal Cancer Interrelations. PLoS One. 2016 Mar 25;11(3):e0152126. doi: 10.1371/journal.pone.0152126. eCollection 2016.
pubmed_id:27015276
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reference_text:Lin Y, Ma C, Liu C, Wang Z, Yang J, Liu X, Shen Z, Wu R: NMR-based fecal metabolomics fingerprinting as predictors of earlier diagnosis in patients with colorectal cancer. Oncotarget. 2016 May 17;7(20):29454-64. doi: 10.18632/oncotarget.8762.
pubmed_id:27107423
[13]:
reference_text:Brown DG, Rao S, Weir TL, O'Malia J, Bazan M, Brown RJ, Ryan EP: Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool. Cancer Metab. 2016 Jun 6;4:11. doi: 10.1186/s40170-016-0151-y. eCollection 2016.
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reference_text:Wang X, Wang J, Rao B, Deng L: Gut flora profiling and fecal metabolite composition of colorectal cancer patients and healthy individuals. Exp Ther Med. 2017 Jun;13(6):2848-2854. doi: 10.3892/etm.2017.4367. Epub 2017 Apr 20.
pubmed_id:28587349
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reference_text:Silke Matysik, Caroline Ivanne Le Roy, Gerhard Liebisch, Sandrine Paule Claus. Metabolomics of fecal samples: A practical consideration. Trends in Food Science & Technology. Vol. 57, Part B, Nov. 2016, p.244-255: http://www.sciencedirect.com/science/article/pii/S0924224416301984
2:
name:Diverticular disease
omim_id:
[1]:
reference_text:Brydon WG, Nyhlin H, Eastwood MA, Merrick MV: Serum 7 alpha-hydroxy-4-cholesten-3-one and selenohomocholyltaurine (SeHCAT) whole body retention in the assessment of bile acid induced diarrhoea. Eur J Gastroenterol Hepatol. 1996 Feb;8(2):117-23.
pubmed_id:8723414
[2]:
reference_text:Tursi A, Mastromarino P, Capobianco D, Elisei W, Miccheli A, Capuani G, Tomassini A, Campagna G, Picchio M, Giorgetti G, Fabiocchi F, Brandimarte G: Assessment of Fecal Microbiota and Fecal Metabolome in Symptomatic Uncomplicated Diverticular Disease of the Colon. J Clin Gastroenterol. 2016 Oct;50 Suppl 1:S9-S12. doi: 10.1097/MCG.0000000000000626.
pubmed_id:27622378
综合参考
Zhang, He; Qi, Shanlong; Yang, Shenggui. Production of N-acetyl-D-glucosamine from chitin. Faming Zhuanli Shenqing Gongkai Shuomingshu (2006), 6pp.
一般参考
1:
protein_accession:HMDBP00332
name:Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
uniprot_id:Q9Y223
gene_name:GNE
protein_type:Enzyme
2:
protein_accession:HMDBP00334
name:N-acylglucosamine 2-epimerase
uniprot_id:P51606
gene_name:RENBP
protein_type:Enzyme
3:
protein_accession:HMDBP00371
name:Beta-1,4-galactosyltransferase 2
uniprot_id:O60909
gene_name:B4GALT2
protein_type:Unknown
4:
protein_accession:HMDBP00377
name:Beta-1,4-galactosyltransferase 1
uniprot_id:P15291
gene_name:B4GALT1
protein_type:Unknown
5:
protein_accession:HMDBP00871
name:Beta-hexosaminidase subunit beta
uniprot_id:P07686
gene_name:HEXB
protein_type:Enzyme
6:
protein_accession:HMDBP00872
name:Beta-hexosaminidase subunit alpha
uniprot_id:P06865
gene_name:HEXA
protein_type:Enzyme
7:
protein_accession:HMDBP01028
name:N-acetyl-D-glucosamine kinase
uniprot_id:Q9UJ70
gene_name:NAGK
protein_type:Enzyme
8:
protein_accession:HMDBP01029
name:Acidic mammalian chitinase
uniprot_id:Q9BZP6
gene_name:CHIA
protein_type:Enzyme
9:
protein_accession:HMDBP01030
name:N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
uniprot_id:Q9UK23
gene_name:NAGPA
protein_type:Enzyme
10:
protein_accession:HMDBP01031
name:Chitotriosidase-1
uniprot_id:Q13231
gene_name:CHIT1
protein_type:Enzyme
11:
protein_accession:HMDBP01032
name:Beta-1,4-galactosyltransferase 3
uniprot_id:O60512
gene_name:B4GALT3
protein_type:Unknown
12:
protein_accession:HMDBP01033
name:Beta-1,4-galactosyltransferase 4
uniprot_id:O60513
gene_name:B4GALT4
protein_type:Unknown
13:
protein_accession:HMDBP01596
name:Alpha-N-acetylglucosaminidase
uniprot_id:P54802
gene_name:NAGLU
protein_type:Enzyme
14:
protein_accession:HMDBP01600
name:Lysozyme C
uniprot_id:P61626
gene_name:LYZ
protein_type:Enzyme
15:
protein_accession:HMDBP08852
name:Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1
uniprot_id:Q8WZA1
gene_name:POMGNT1
protein_type:Unknown
16:
protein_accession:HMDBP10139
name:Lysozyme-like protein 1
uniprot_id:Q6UWQ5
gene_name:LYZL1
protein_type:Enzyme
17:
protein_accession:HMDBP10634
name:Lysozyme-like protein 2
uniprot_id:Q7Z4W2
gene_name:LYZL2
protein_type:Enzyme
18:
protein_accession:HMDBP10635
name:Sperm acrosome-associated protein 5
uniprot_id:Q96QH8
gene_name:SPACA5
protein_type:Enzyme
19:
protein_accession:HMDBP10636
name:Lysozyme-like protein 6
uniprot_id:O75951
gene_name:LYZL6
protein_type:Enzyme
20:
protein_accession:HMDBP11635
name:Chitinase-3-like protein 1
uniprot_id:P36222
gene_name:CHI3L1
protein_type:Unknown
21:
protein_accession:HMDBP11636
name:Chitinase-3-like protein 2
uniprot_id:Q15782
gene_name:CHI3L2
protein_type:Unknown
22:
protein_accession:HMDBP11780
name:Hexosaminidase D
uniprot_id:Q8WVB3
gene_name:HEXDC
protein_type:Unknown
23:
protein_accession:HMDBP11851
name:Bifunctional protein NCOAT
uniprot_id:O60502
gene_name:MGEA5
protein_type:Unknown
蛋白质结合
1:
reference_text:Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762.
pubmed_id:19212411
2:
reference_text:Nakagawa F, Schulte BA, Spicer SS: Lectin cytochemical evaluation of somatosensory neurons and their peripheral and central processes in rat and man. Cell Tissue Res. 1986;245(3):579-89.
pubmed_id:3757018
3:
reference_text:Hatcher VB, Schwarzmann GO, Jeanloz RW, McArthur JW: Changes in the sialic acid concentration in the major cervical glycoprotein from the bonnet monkey (Macaca radiata) during a hormonally induced cycle. Fertil Steril. 1977 Jun;28(6):682-8.
pubmed_id:405259
4:
reference_text:Percheron F: [Beta-D-mannosidase]. Bull Acad Natl Med. 1995 May;179(5):881-91; discussion 892.
pubmed_id:7583460
5:
reference_text:Collard CD, Montalto MC, Reenstra WR, Buras JA, Stahl GL: Endothelial oxidative stress activates the lectin complement pathway: role of cytokeratin 1. Am J Pathol. 2001 Sep;159(3):1045-54.
pubmed_id:11549596
6:
reference_text:Mollicone R, Candelier JJ, Mennesson B, Couillin P, Venot AP, Oriol R: Five specificity patterns of (1----3)-alpha-L-fucosyltransferase activity defined by use of synthetic oligosaccharide acceptors. Differential expression of the enzymes during human embryonic development and in adult tissues. Carbohydr Res. 1992 Apr 10;228(1):265-76.
pubmed_id:1366057
7:
reference_text:Kottgen E, Hell B, Muller C, Kainer F, Tauber R: Developmental changes in the glycosylation and binding properties of human fibronectins. Characterization of the glycan structures and ligand binding of human fibronectins from adult plasma, cord blood and amniotic fluid. Biol Chem Hoppe Seyler. 1989 Dec;370(12):1285-94.
pubmed_id:2619923
8:
reference_text:Madrid JF, Castells MT, Martinez-Menarguez JA, Aviles M, Hernandez F, Ballesta J: Subcellular characterization of glycoproteins in the principal cells of human gallbladder. A lectin cytochemical study. Histochemistry. 1994 Mar;101(3):195-204.
pubmed_id:8056619
9:
reference_text:Weiner B, Fischer T, Waxman S: Hemostasis in the era of the chronic anticoagulated patient. J Invasive Cardiol. 2003 Nov;15(11):669-73; quiz 674.
pubmed_id:14608143
10:
reference_text:Yates AD, Watkins WM: Enzymes involved in the biosynthesis of glycoconjugates. A UDP-2-acetamido-2-deoxy-D-glucose: beta-D-galactopyranosyl-(1 leads to 4)-saccharide (1 leads to 3)-2-acetamido-2-deoxy-beta-D- glucopyranosyltransferase in human serum. Carbohydr Res. 1983 Aug 16;120:251-68.
pubmed_id:6226355
11:
reference_text:Slawson C, Housley MP, Hart GW: O-GlcNAc cycling: how a single sugar post-translational modification is changing the way we think about signaling networks. J Cell Biochem. 2006 Jan 1;97(1):71-83.
pubmed_id:16237703
12:
reference_text:Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043.
pubmed_id:32033212