创建日期
2005-11-16 15:48:42 UTC
更新日期
2021-09-14 15:46:06 UTC
二级访问
HMDB0000835
HMDB00212
HMDB00835
描述
N-Acetylgalactosamine, also known as GalNAc, belongs to the class of organic compounds known as N-acyl-alpha-hexosamines. These are carbohydrate derivatives containing a hexose moiety in which the oxygen atom is replaced by an N-acyl group. N-Acetylgalactosamine is also classified as an amino sugar derivative of galactose. In humans GalNAc functions as the terminal carbohydrate forming the antigen of blood group A. GalNAc is typically the first monosaccharide that connects serine or threonine during protein O-glycosylation and the formation of glycoproteins. This is often referred to as mucin-type O-glycosylation, as the mucins (a class of a family of high molecular weight, heavily glycosylated proteins produced by epithelial tissues in most animals which have an ability to form gels) are heavily O-GalNAc modified. Interestingly, mammals have genes encoding for approximately 20 different polypeptide-N-acetylgalactosaminyltransferases (ppGalNAcTs), all of which transfer GalNAc from UDP-GalNAc to a hydroxyl-containing amino acids such as serine or threonine. N- O-GalNAc-containing glycoproteins appear to play a variety of essential roles. Among these is the ability of the mucins to hydrate and protect tissues by trapping bacteria. These O-glycans can also significantly alter the conformation of the protein and on the heavily modified proteins may protect the polypeptide from proteolytic digestion. O-GalNAc structures also appear to play an essential role in sperm–egg interactions. From a pathophysiological perspective, O-GalNAc modification appears to play a critical role in the immune system, cell–cell interactions, and cancer. N-Acetylgalactosamine is an important constituent of brain heteropolysaccharides (glycoproteins). The concentration of the N-acetylgalactosamine-containing glycoproteins in the 3-year-old cerebral gray matter from human brain is 7-15 times greater than in 8-year old tissue and 15-30 times greater than in 72-year-old tissue. Outside of the human body, N-Acetylgalactosamine has been detected, but not quantified in, several different foods, such as prickly pears, italian sweet red peppers, wheats, silver lindens, and sour cherries. This could make N-acetylgalactosamine a potential biomarker for the consumption of these foods.
同义词
1:2-(Acetylamino)-2-deoxy-alpha-D-galactopyranose
2:alpha-GalNAc
3:alpha-GalpNAc
4:GalNAc-alpha
5:Tn
6:TN Antigen saccharide
7:TN Antigen saccharide component
8:TN Saccharide
9:TN Saccharide component
10:2-(Acetylamino)-2-deoxy-a-D-galactopyranose
11:2-(Acetylamino)-2-deoxy-α-D-galactopyranose
12:a-GalNAc
13:Α-galnac
14:a-GalpNAc
15:Α-galpnac
16:GalNAc-a
17:GalNAc-α
18:2-Acetamido-2-deoxy-a-D-allopyranose
19:2-Acetamido-2-deoxy-a-D-glucopyranose
20:2-Acetamido-2-deoxy-alpha-D-allopyranose
21:2-Acetamido-2-deoxy-alpha-D-glucopyranose
22:2-Acetamido-2-deoxy-alpha-delta-allopyranose
23:2-Acetamido-2-deoxy-alpha-delta-glucopyranose
24:2-Acetamido-2-deoxy-b-D-glucopyranose
25:2-Acetamido-2-deoxy-beta-D-glucopyranose
26:2-Acetamido-2-deoxy-beta-delta-glucopyranose
27:2-Acetamido-2-desoxy-b-D-talofuranose
28:2-Acetamido-2-desoxy-beta-D-talofuranose
29:2-Acetamido-2-desoxy-beta-delta-talofuranose
30:2-Acetamino-2-deoxy-a-D-glucose
31:2-Acetamino-2-deoxy-alpha-D-glucose
32:2-Acetamino-2-deoxy-alpha-delta-glucose
33:2-Acetamino-2-desoxy-a-D-glucopyranose
34:2-Acetamino-2-desoxy-alpha-D-glucopyranose
35:2-Acetamino-2-desoxy-alpha-delta-glucopyranose
36:2-Acetamino-2-desoxy-D-galaktose
37:2-Acetamino-2-desoxy-D-glucose
38:2-Acetamino-2-desoxy-delta-galaktose
39:2-Acetamino-2-desoxy-delta-glucose
40:2-Acetylamino-2-deoxy-a-D-galactopyranose
41:2-Acetylamino-2-deoxy-a-D-glucopyranose
42:2-Acetylamino-2-deoxy-a-D-mannopyranose
43:2-Acetylamino-2-deoxy-alpha-D-galactopyranose
44:2-Acetylamino-2-deoxy-alpha-D-glucopyranose
45:2-Acetylamino-2-deoxy-alpha-D-mannopyranose
46:2-Acetylamino-2-deoxy-alpha-delta-galactopyranose
47:2-Acetylamino-2-deoxy-alpha-delta-glucopyranose
48:2-Acetylamino-2-deoxy-alpha-delta-mannopyranose
49:2-Acetylamino-2-deoxy-b-D-allopyranose
50:2-Acetylamino-2-deoxy-b-D-altropyranose
51:2-Acetylamino-2-deoxy-b-D-galactopyranose
52:2-Acetylamino-2-deoxy-b-D-glucopyranose
53:2-Acetylamino-2-deoxy-b-D-mannopyranose
54:2-Acetylamino-2-deoxy-beta-D-allopyranose
55:2-Acetylamino-2-deoxy-beta-D-altropyranose
56:2-Acetylamino-2-deoxy-beta-D-galactopyranose
57:2-Acetylamino-2-deoxy-beta-D-glucopyranose
58:2-Acetylamino-2-deoxy-beta-D-mannopyranose
59:2-Acetylamino-2-deoxy-beta-delta-allopyranose
60:2-Acetylamino-2-deoxy-beta-delta-altropyranose
61:2-Acetylamino-2-deoxy-beta-delta-galactopyranose
62:2-Acetylamino-2-deoxy-beta-delta-glucopyranose
63:2-Acetylamino-2-deoxy-beta-delta-mannopyranose
64:2-Acetylamino-2-desoxy-a-D-galaktose
65:2-Acetylamino-2-desoxy-a-D-mannose
66:2-Acetylamino-2-desoxy-alpha-D-galaktose
67:2-Acetylamino-2-desoxy-alpha-D-mannose
68:2-Acetylamino-2-desoxy-alpha-delta-galaktose
69:2-Acetylamino-2-desoxy-alpha-delta-mannose
70:2-Acetylamino-2-desoxy-b-D-galaktose
71:2-Acetylamino-2-desoxy-b-D-mannose
72:2-Acetylamino-2-desoxy-beta-D-galaktose
73:2-Acetylamino-2-desoxy-beta-D-mannose
74:2-Acetylamino-2-desoxy-beta-delta-galaktose
75:2-Acetylamino-2-desoxy-beta-delta-mannose
76:2-Acetylamino-2-desoxy-D-mannose
77:2-Acetylamino-2-desoxy-delta-mannose
78:2-Acetylamino-2-desoxy-DL-glucopyranose
79:2-Acetylamino-a-D-2-deoxy-galactopyranose
80:2-Acetylamino-a-D-2-deoxy-glucopyranose
81:2-Acetylamino-a-D-2-deoxy-glucose
82:2-Acetylamino-a-D-2-deoxy-mannopyranose
83:2-Acetylamino-alpha-D-2-deoxy-galactopyranose
84:2-Acetylamino-alpha-D-2-deoxy-glucopyranose
85:2-Acetylamino-alpha-D-2-deoxy-glucose
86:2-Acetylamino-alpha-D-2-deoxy-mannopyranose
87:2-Acetylamino-alpha-delta-2-deoxy-galactopyranose
88:2-Acetylamino-alpha-delta-2-deoxy-glucopyranose
89:2-Acetylamino-alpha-delta-2-deoxy-glucose
90:2-Acetylamino-alpha-delta-2-deoxy-mannopyranose
91:2-Acetylamino-b-D-2-deoxy-galactopyranose
92:2-Acetylamino-b-D-2-deoxy-glucopyranose
93:2-Acetylamino-b-D-2-deoxy-mannopyranose
94:2-Acetylamino-beta-D-2-deoxy-galactopyranose
95:2-Acetylamino-beta-D-2-deoxy-glucopyranose
96:2-Acetylamino-beta-D-2-deoxy-mannopyranose
97:2-Acetylamino-beta-delta-2-deoxy-galactopyranose
98:2-Acetylamino-beta-delta-2-deoxy-glucopyranose
99:2-Acetylamino-beta-delta-2-deoxy-mannopyranose
100:2-Acetylamino-D-2-deoxy-galactose
101:2-Acetylamino-D-2-deoxy-glucose
102:2-Acetylamino-D-2-deoxy-gulose
103:2-Acetylamino-D-2-deoxy-idose
104:2-Acetylamino-D-2-deoxy-mannose
105:2-Acetylamino-D-2-deoxy-talose
106:2-Acetylamino-delta-2-deoxy-galactose
107:2-Acetylamino-delta-2-deoxy-glucose
108:2-Acetylamino-delta-2-deoxy-gulose
109:2-Acetylamino-delta-2-deoxy-idose
110:2-Acetylamino-delta-2-deoxy-mannose
111:2-Acetylamino-delta-2-deoxy-talose
112:2-Acetylamino-L-2-deoxy-galactose
113:2-Acetylamino-L-2-deoxy-mannose
114:a-2-Acetamido-2-deoxy-D-galactose
115:alpha-2-Acetamido-2-deoxy-D-galactose
116:alpha-2-Acetamido-2-deoxy-delta-galactose
117:GalNAc
118:N-(2,4,5-Trihydroxy-6-hydroxymethyl-tetrahydro-pyran-3-yl)-acetamide
119:N-Acetyl-a-D-glucosamine
120:N-Acetyl-alpha-D-glucosamine
121:N-Acetyl-alpha-delta-glucosamine
122:N-Acetyl-D-allosamine
123:N-Acetyl-D-galactosamine
124:N-Acetyl-delta-allosamine
125:N-Acetyl-delta-galactosamine
126:N-Acetylgalactosamin
127:N-Acetylglucosamin
128:N-Acetylgluosamin
129:N-Acetylmannosamin
130:2 Acetamido 2 deoxy D galactose
131:2-Acetamido-2-D-galactopyranose
132:Acetylgalactosamine
133:2-Acetamido-2-deoxygalactose
134:N Acetyl D galactosamine
135:2 Acetamido 2 D galactopyranose
136:2 Acetamido 2 deoxygalactose
137:2-Acetamido-2-deoxy-D-galactose
138:N-Acetyl-a-D-galactosamine
139:N-Acetyl-α-D-galactosamine
140:a-N-Acetyl-D-galactosamine
141:Α-N-acetyl-D-galactosamine
化学名称
N-[(2S,3R,4R,5R,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide
代谢物结构字符串
CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O
inchi标识符
InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8+/m1/s1
印记键
OVRNDRQMDRJTHS-CBQIKETKSA-N
分类学
description: belongs to the class of organic compounds known as n-acyl-alpha-hexosamines. These are carbohydrate derivatives containing a hexose moiety in which the oxygen atom is replaced by an n-acyl group.
description:N-acyl-alpha-hexosamines
kingdom:Organic compounds
super_class:Organic oxygen compounds
class:Organooxygen compounds
sub_class:Carbohydrates and carbohydrate conjugates
molecular_framework:Aliphatic heteromonocyclic compounds
1:Carboximidic acids
2:Hemiacetals
3:Hexoses
4:Hydrocarbon derivatives
5:Organonitrogen compounds
6:Organopnictogen compounds
7:Oxacyclic compounds
8:Oxanes
9:Polyols
10:Primary alcohols
11:Propargyl-type 1,3-dipolar organic compounds
12:Secondary alcohols
13:Alcohol
14:Aliphatic heteromonocyclic compound
15:Carboximidic acid
16:Carboximidic acid derivative
17:Hemiacetal
18:Hexose monosaccharide
19:Hydrocarbon derivative
20:Monosaccharide
21:N-acyl-alpha-hexosamine
22:Organic 1,3-dipolar compound
23:Organic nitrogen compound
24:Organoheterocyclic compound
25:Organonitrogen compound
26:Organopnictogen compound
27:Oxacycle
28:Oxane
29:Polyol
30:Primary alcohol
31:Propargyl-type 1,3-dipolar organic compound
32:Secondary alcohol
33:N-acetyl-D-galactosamine
本体论
term:Disposition
definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.
parent_id:
level:1
type:parent
term:Route of exposure
definition:A mean by which a chemical agent comes in contact with an organism, either under intended or unintended circumstances.
parent_id:7724
*level:2
type:parent
term:Enteral
definition:Chemical exposure via the alimentary canal (mouth to anus).
parent_id:7743
**level:3
type:parent
term:Ingestion
definition:Chemical exposure facilitated by entry through the mouth.
parent_id:7744
***level:4
type:child
synonym:Digestion
term:Source
definition:Natural or synthetic origin of a chemical.
parent_id:7724
*level:2
type:parent
term:Endogenous
definition:
parent_id:7735
**level:3
type:child
term:Food
definition:
parent_id:7735
**level:3
type:child
term:Biological
definition:A living organism (species or a higher taxonomy rank), in which a chemical can be found.
parent_id:7735
**level:3
type:parent
term:Plant
definition:A living organism belonging to the kingdom plantea. typically, it grows in a permanent site, absorbs water and inorganic substances through its roots, and synthesizes nutrients in its leaves by photosynthesis using the green pigment chlorophyll. examples incude trees, shrubs, herbs, grasses, ferns, and mosses.
parent_id:7736
***level:4
type:parent
synonym:Flora
term:Animal
definition:A living organism belonging to the kingdom animalia. it feeds on organic matter, typically having specialized sense organs and nervous system and able to respond rapidly to stimuli.
parent_id:7736
***level:4
type:child
synonym:Fauna
term:Biological location
definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.
parent_id:7724
*level:2
type:parent
term:Cell and elements
definition:An anatomical organizational level comprising of a single cell (or a fragment in some exceptions). a cell is defined by its type or function. it is the smallest unit of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid.
parent_id:7725
**level:3
type:parent
term:Cell
definition:
parent_id:7732
***level:4
type:parent
term:Organ and components
definition:An anatomical organizational level including multiple tissues or substructures, which enables a common biological function.
parent_id:7725
**level:3
type:parent
term:Intestine
definition:The portion of the gastrointestinal tract that includes the small and large intestines.
parent_id:7727
***level:4
type:child
term:Testicle
definition:Either of the paired male reproductive glands that produce the male germ cells and the male hormones. (nci).
parent_id:7727
***level:4
type:child
synonym:Testes
synonym:Testis
term:Spleen
definition:An abdominal organ that is part of the hematopoietic and immune systems. it is composed of the white pulp and the red pulp and is surrounded by a capsule. (nci).
parent_id:7727
***level:4
type:child
term:Brain
definition:An organ composed of grey and white matter that is the center for intelligence and reasoning. it is protected by the bony cranium. (nci).
parent_id:7727
***level:4
type:child
term:Liver
definition:An abdominal organ that has variable lobation which are composed mainly of hepatic lobules. (nci).
parent_id:7727
***level:4
type:child
term:Prostate
definition:The male reproductive accessory gland that produces prostatic fluid and is located adjacent to or around the urethra distal to the urinary bladder in mammals. (nci).
parent_id:7727
***level:4
type:child
synonym:Prostate gland
term:Pancreas
definition:A digestive organ in the abdomen that has both endocrine and exocrine functions. (nci).
parent_id:7727
***level:4
type:child
term:Tissue and substructures
definition:An anatomical organizational level including multiple cells yet not comprising a complete organ .
parent_id:7725
**level:3
type:parent
term:Placenta
definition:An organ present in some vertebrates during embryonic gestation that surrounds the fetus and provides it with nutrients and oxygen, facilitates gas and waste exchange between the fetus and mother, and provides parasitic cloaking from the mother's immune system by excretion of neurokinin b. (nci).
parent_id:7729
***level:4
type:child
term:Epidermis
definition:The epithelial portion of the skin (cutis). it consists of the following layers: stratum corneum (horny layer), stratum granulosum (granular layer), stratum spinosum (prickle cell layer), and stratum basale (basal cell layer). (nci).
parent_id:7729
***level:4
type:child
term:Skeletal muscle
definition:Striated muscles that are under voluntary control of the organism. they are connected at either or both ends to a bone and are utilized for locomotion and other movements. (nci).
parent_id:7729
***level:4
type:child
synonym:Striated muscle
term:Adipose tissue
definition:A specialized form of connective tissue consisting primarily of adipocytes (fat cells), surrounded by a meshwork of collagen fibers. (NCI)
parent_id:7729
***level:4
type:child
synonym:Fat tissue
synonym:Body fat
synonym:Adipose
term:Muscle
definition:A fibrous soft tissue with the ability to contract to produce force and motion. (nci).
parent_id:7729
***level:4
type:child
term:Subcellular
definition:An anatomical organizational level including a component within a biological cell .
parent_id:7725
**level:3
type:parent
term:Lysosome
definition:В A sac-like compartment inside a cell that has enzymes that can break down cellular components that need to be destroyed. (NCI).
parent_id:7730
***level:4
type:child
term:Golgi
definition:A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. Note that the Golgi apparatus can be located in various places in the cytoplasm.
parent_id:7730
***level:4
type:child
synonym:Golgi apparatus
synonym:Golgi complex
synonym:Golgi ribbon
term:Myelin sheath
definition:A layer of phospholipids and protein found on neuronal axons. this structure acts as an electrical insulator that allows nerve impulses to travel faster by increasing the resistance and decreasing the capacitance over that found in unmyelinated nerve fibers. (nci).
parent_id:7730
***level:4
type:child
synonym:Myelin
term:Biofluid and excreta
definition:A liquid, semi-solid or solid material originating in the body.
parent_id:7725
**level:3
type:parent
term:Feces
definition:The material discharged from the bowel during defecation. It consists of undigested food, intestinal mucus, epithelial cells, and bacteria.
parent_id:7731
***level:4
type:child
synonym:Fecal
synonym:Stool
synonym:Faecal
synonym:Faeces
term:Saliva
definition:The watery fluid in the mouth made by the salivary glands. saliva moistens food to help digestion and it helps protect the mouth against infections. (nci).
parent_id:7731
***level:4
type:child
term:Role
definition:The purpose or function assumed by a chemical, either naturally or as intended by humans .
parent_id:
level:1
type:parent
term:Industrial application
definition:The assumed function of a chemical utilized by human.
parent_id:7671
*level:2
type:parent
term:Pharmaceutical industry
definition:A pharmacologic activity for which a chemical substance is utilized owing to its biological role.
parent_id:7678
**level:3
type:parent
term:Pharmaceutical
definition:
parent_id:7679
***level:4
type:child
实验性质
1:
kind:melting_point
value:172 - 173 °C
source:
预测性质
1:
kind:logp
value:-2.60
source:ALOGPS
2:
kind:logs
value:0.06
source:ALOGPS
3:
kind:solubility
value:254 g/L
source:ALOGPS
4:
kind:logp
value:-3.2
source:ChemAxon
5:
kind:pka_strongest_acidic
value:11.6
source:ChemAxon
6:
kind:pka_strongest_basic
value:-1.6
source:ChemAxon
7:
kind:iupac
value:N-[(2S,3R,4R,5R,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide
source:ChemAxon
8:
kind:average_mass
value:221.2078
source:ChemAxon
9:
kind:mono_mass
value:221.089937217
source:ChemAxon
10:
kind:smiles
value:CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O
source:ChemAxon
11:
kind:formula
value:C8H15NO6
source:ChemAxon
12:
kind:inchi
value:InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8+/m1/s1
source:ChemAxon
13:
kind:inchikey
value:OVRNDRQMDRJTHS-CBQIKETKSA-N
source:ChemAxon
14:
kind:polar_surface_area
value:119.25
source:ChemAxon
15:
kind:refractivity
value:47.02
source:ChemAxon
16:
kind:polarizability
value:20.58
source:ChemAxon
17:
kind:rotatable_bond_count
value:2
source:ChemAxon
18:
kind:acceptor_count
value:6
source:ChemAxon
19:
kind:donor_count
value:5
source:ChemAxon
20:
kind:physiological_charge
value:0
source:ChemAxon
21:
kind:formal_charge
value:0
source:ChemAxon
22:
kind:number_of_rings
value:1
source:ChemAxon
23:
kind:bioavailability
value:Yes
source:ChemAxon
24:
kind:rule_of_five
value:Yes
source:ChemAxon
25:
kind:ghose_filter
value:No
source:ChemAxon
26:
kind:veber_rule
value:No
source:ChemAxon
27:
kind:mddr_like_rule
value:No
source:ChemAxon
生物学性质
1:
cellular:(1):Golgi apparatus
cellular:(2):Lysosome
2:
biospecimen:(1):Feces
biospecimen:(2):Saliva
3:
tissue:(1):Adipose Tissue
tissue:(2):Brain
tissue:(3):Epidermis
tissue:(4):Intestine
tissue:(5):Liver
tissue:(6):Neuron
tissue:(7):Pancreas
tissue:(8):Placenta
tissue:(9):Prostate
tissue:(10):Skeletal Muscle
tissue:(11):Spleen
tissue:(12):Testis
4:
正常浓度
1:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
2:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
3:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
4:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
5:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
6:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
7:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
8:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
9:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
10:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
11:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
12:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
异常浓度
1:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Colorectal Cancer
疾病参考
1:
name:Colorectal cancer
omim_id:114500
[1]:
reference_text:Ishiwata S, Itoh K, Yamaguchi T, Ishida N, Mizugaki M: Comparison of serum and urinary levels of modified nucleoside, 1-methyladenosine, in cancer patients using a monoclonal antibody-based inhibition ELISA. Tohoku J Exp Med. 1995 May;176(1):61-8.
pubmed_id:7482520
[2]:
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reference_text:Ritchie SA, Ahiahonu PW, Jayasinghe D, Heath D, Liu J, Lu Y, Jin W, Kavianpour A, Yamazaki Y, Khan AM, Hossain M, Su-Myat KK, Wood PL, Krenitsky K, Takemasa I, Miyake M, Sekimoto M, Monden M, Matsubara H, Nomura F, Goodenowe DB: Reduced levels of hydroxylated, polyunsaturated ultra long-chain fatty acids in the serum of colorectal cancer patients: implications for early screening and detection. BMC Med. 2010 Feb 15;8:13. doi: 10.1186/1741-7015-8-13.
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维基百科编号
N-Acetylgalactosamine
综合参考
Cardini, C. E.; Leloir, Luis F. Enzymic formation of acetylgalactosamine. Journal of Biological Chemistry (1957), 225 317-24.
一般参考
1:
protein_accession:HMDBP01054
name:UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1
uniprot_id:O75752
gene_name:B3GALNT1
protein_type:Unknown
2:
protein_accession:HMDBP01140
name:N-acetylgalactosamine kinase
uniprot_id:Q01415
gene_name:GALK2
protein_type:Enzyme
3:
protein_accession:HMDBP02166
name:N-acetylgalactosamine-6-sulfatase
uniprot_id:P34059
gene_name:GALNS
protein_type:Unknown
4:
protein_accession:HMDBP03131
name:UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter
uniprot_id:Q9NTN3
gene_name:SLC35D1
protein_type:Enzyme
5:
protein_accession:HMDBP06256
name:UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
uniprot_id:Q8NFL0
gene_name:B3GNT7
protein_type:Enzyme
6:
protein_accession:HMDBP06975
name:Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
uniprot_id:Q9NS00
gene_name:C1GALT1
protein_type:Unknown
7:
protein_accession:HMDBP09151
name:Beta-1,4-N-acetylgalactosaminyltransferase 3
uniprot_id:Q6L9W6
gene_name:B4GALNT3
protein_type:Enzyme
8:
protein_accession:HMDBP09173
name:N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1
uniprot_id:Q76KP1
gene_name:B4GALNT4
protein_type:Enzyme
9:
protein_accession:HMDBP09214
name:Beta-1,4 N-acetylgalactosaminyltransferase 2
uniprot_id:Q8NHY0
gene_name:B4GALNT2
protein_type:Enzyme
10:
protein_accession:HMDBP09372
name:Hyaluronidase-1
uniprot_id:Q12794
gene_name:HYAL1
protein_type:Enzyme
11:
protein_accession:HMDBP09373
name:Hyaluronidase PH-20
uniprot_id:P38567
gene_name:SPAM1
protein_type:Enzyme
12:
protein_accession:HMDBP09374
name:Hyaluronidase-2
uniprot_id:Q12891
gene_name:HYAL2
protein_type:Enzyme
蛋白质结合
1:
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pubmed_id:9639683
2:
reference_text:Zhang Y, Iwasaki H, Wang H, Kudo T, Kalka TB, Hennet T, Kubota T, Cheng L, Inaba N, Gotoh M, Togayachi A, Guo J, Hisatomi H, Nakajima K, Nishihara S, Nakamura M, Marth JD, Narimatsu H: Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen. J Biol Chem. 2003 Jan 3;278(1):573-84. Epub 2002 Oct 28.
pubmed_id:12407114
3:
reference_text:White T, Bennett EP, Takio K, Sorensen T, Bonding N, Clausen H: Purification and cDNA cloning of a human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase. J Biol Chem. 1995 Oct 13;270(41):24156-65.
pubmed_id:7592619
4:
reference_text:Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762.
pubmed_id:19212411
5:
reference_text:Nakagawa F, Schulte BA, Spicer SS: Lectin cytochemical evaluation of somatosensory neurons and their peripheral and central processes in rat and man. Cell Tissue Res. 1986;245(3):579-89.
pubmed_id:3757018
6:
reference_text:Kamakura K, Kaida K, Kusunoki S, Miyamoto N, Masaki T, Nakamura R, Motoyoshi K, Fukuda J: Harmful effects of anti-GalNAc-GD1a antibodies and TNF-alpha on rat dorsal root ganglia. J Peripher Nerv Syst. 2005 Jun;10(2):190-201.
pubmed_id:15958130
7:
reference_text:Petri WA Jr, Chaudhry O, Haque R, Houpt E: Adherence-blocking vaccine for amebiasis. Arch Med Res. 2006 Feb;37(2):288-91.
pubmed_id:16380334
8:
reference_text:Petry K, Greinix HT, Nudelman E, Eisen H, Hakomori S, Levy HL, Reichardt JK: Characterization of a novel biochemical abnormality in galactosemia: deficiency of glycolipids containing galactose or N-acetylgalactosamine and accumulation of precursors in brain and lymphocytes. Biochem Med Metab Biol. 1991 Aug;46(1):93-104.
pubmed_id:1931160
9:
reference_text:Kaida K, Kusunoki S, Kamakura K, Motoyoshi K, Kanazawa I: GalNAc-GD1a in human peripheral nerve: target sites of anti-ganglioside antibody. Neurology. 2003 Aug 26;61(4):465-70.
pubmed_id:12939418
10:
reference_text:Gupta D, Sabesan S, Brewer CF: Selective inhibition of N-acetylglucosamine and galactose-specific lectins including the 14-kDa vertebrate lectin by novel synthetic biantennary oligosaccharides. Eur J Biochem. 1993 Sep 15;216(3):789-97.
pubmed_id:8404897
11:
reference_text:Sutherlin ME, Nishimori I, Caffrey T, Bennett EP, Hassan H, Mandel U, Mack D, Iwamura T, Clausen H, Hollingsworth MA: Expression of three UDP-N-acetyl-alpha-D-galactosamine:polypeptide GalNAc N-acetylgalactosaminyltransferases in adenocarcinoma cell lines. Cancer Res. 1997 Nov 1;57(21):4744-8.
pubmed_id:9354435
12:
reference_text:Kariniemi AL, Virtanen I: Dolichos biflorus agglutinin (DBA) reveals a similar basal cell differentiation in normal and psoriatic epidermis. Histochemistry. 1989;93(2):129-32.
pubmed_id:2482277
13:
reference_text:Yuki N: Infectious origins of, and molecular mimicry in, Guillain-Barre and Fisher syndromes. Lancet Infect Dis. 2001 Aug;1(1):29-37.
pubmed_id:11871407
14:
reference_text:Tao X, Gao G, Zhang HZ, Zhu DX, Boersma A, Lamblin G, Han KK: Isolation and characterization of human urinary colony-stimulating factor. Biol Chem Hoppe Seyler. 1987 Mar;368(3):187-94.
pubmed_id:3496105
15:
reference_text:Hiruma T, Togayachi A, Okamura K, Sato T, Kikuchi N, Kwon YD, Nakamura A, Fujimura K, Gotoh M, Tachibana K, Ishizuka Y, Noce T, Nakanishi H, Narimatsu H: A novel human beta1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAcbeta1-3GlcNAc. J Biol Chem. 2004 Apr 2;279(14):14087-95. Epub 2004 Jan 14.
pubmed_id:14724282
16:
reference_text:Chikakiyo H, Kunishige M, Yoshino H, Asano A, Sumitomo Y, Endo I, Matsumoto T, Mitsui T: Delayed motor and sensory neuropathy in a patient with brainstem encephalitis. J Neurol Sci. 2005 Jul 15;234(1-2):105-8.
pubmed_id:15936038
17:
reference_text:Roelen HC, Bijsterbosch MK, Bakkeren HF, van Berkel TJ, Kempen HJ, Buytenhek M, van der Marel GA, van Boom JH: Water-soluble cholesteryl-containing phosphorothioate monogalactosides: synthesis, properties, and use in lowering blood cholesterol by directing plasma lipoproteins to the liver. J Med Chem. 1991 Mar;34(3):1036-42.
pubmed_id:2002447
18:
reference_text:Smith PL, Bousfield GR, Kumar S, Fiete D, Baenziger JU: Equine lutropin and chorionic gonadotropin bear oligosaccharides terminating with SO4-4-GalNAc and Sia alpha 2,3Gal, respectively. J Biol Chem. 1993 Jan 15;268(2):795-802.
pubmed_id:8419356
19:
reference_text:Szkudlinski MW, Thotakura NR, Tropea JE, Grossmann M, Weintraub BD: Asparagine-linked oligosaccharide structures determine clearance and organ distribution of pituitary and recombinant thyrotropin. Endocrinology. 1995 Aug;136(8):3325-30.
pubmed_id:7628367
20:
reference_text:Taguchi K, Ren J, Utsunomiya I, Aoyagi H, Fujita N, Ariga T, Miyatake T, Yoshino H: Neurophysiological and immunohistochemical studies on Guillain-Barre syndrome with IgG anti-GalNAc-GD1a antibodies-effects on neuromuscular transmission. J Neurol Sci. 2004 Oct 15;225(1-2):91-8.
pubmed_id:15465091
21:
reference_text:Hoyte K, Kang C, Martin PT: Definition of pre- and postsynaptic forms of the CT carbohydrate antigen at the neuromuscular junction: ubiquitous expression of the CT antigens and the CT GalNAc transferase in mouse tissues. Brain Res Mol Brain Res. 2002 Dec 30;109(1-2):146-60.
pubmed_id:12531524
22:
reference_text:Brunngraber EG, Brown BD, Aro A: Distribution and age-dependent concentration in brain tissue of glycoproteins containing N-acetylgalactosamine. Neurobiology. 1975 Dec;5(6):339-46.
pubmed_id:1207868
23:
reference_text:Maury CP: Carbohydrate patterns of endoscopic mucosal biopsies in cancer of the stomach and chronic gastritis. Clin Chim Acta. 1982 Dec 9;126(2):155-9.
pubmed_id:7151277
24:
reference_text:Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043.
pubmed_id:32033212
25:
reference_text:Pastuszak I, Drake R, Elbein AD. Kidney N-acetylgalactosamine (GalNAc)-1-phosphate kinase, a new pathway of GalNAc activation. J Biol Chem. 1996 Aug 23;271(34):20776-82.