版本
5.0
创建日期
2005-11-16 15:48:42 UTC
更新日期
2020-11-09 23:12:41 UTC
登录号
HMDB0000197
地位
quantified
二级访问
HMDB00197

名称
Indoleacetic acid
描述
Indoleacetic acid (IAA) is a breakdown product of tryptophan metabolism and is often produced by the action of bacteria in the mammalian gut. Higher levels of IAA are associated with bacteria from Clostridium species including C. stricklandii, C. lituseburense, C. subterminale, and C. putrefaciens (PMID: 12173102). IAA can be found in Agrobacterium, Azospirillum, Bacillus, Bradyrhizobium, Clostridium, Enterobacter, Pantoea, Pseudomonas, Rhizobium (PMID: 12173102, PMID: 17555270, PMID: 12147474, PMID: 19400643, PMID: 9450337, PMID: 21397014) (https://link.springer.com/chapter/10.1007/978-1-4612-3084-7_7) (https://escholarship.org/uc/item/1bf1b5m3). Some endogenous production of IAA in mammalian tissues also occurs. It may be produced by the decarboxylation of tryptamine or the oxidative deamination of tryptophan. IAA frequently occurs at low levels in urine and has been found in elevated levels in the urine of patients with phenylketonuria (PMID: 13610897). IAA has also been identified as a uremic toxin according to the European Uremic Toxin Working Group (PMID: 22626821). Using material extracted from human urine, it was discovered by Kogl in 1933 that indoleacetic acid is also an important plant hormone (PMID: 13610897). Specifically, IAA is a member of the group of phytohormones called auxins. IAA is generally considered to be the most important native auxin. Plant cells synthesize IAA from tryptophan (Wikipedia). IAA and some derivatives can be oxidized by horseradish peroxidase (HRP) into cytotoxic species. IAA is only toxic after oxidative decarboxylation; the effect of IAA/HRP is thought to be due in part to the formation of methylene-oxindole, which may conjugate with DNA bases and protein thiols. IAA/HRP could be used as the basis for targeted cancer, a potential new role for plant auxins in cancer therapy (PMID: 11163327).
同义词
1:(indol-3-yl)Acetate

2:(indol-3-yl)Acetic acid

3:2-(indol-3-yl)Ethanoic acid

4:3-Indolylessigsaeure

5:Heteroauxin

6:IAA

7:IES

8:Indole-3-acetic acid

9:Indoleacetate

10:(1H-indol-3-yl)Acetate

11:2-(indol-3-yl)Ethanoate

12:Indole-3-acetate

13:(1H-indol-3-yl)Acetic acid

14:(1H-indol-3-yl)-Acetate

15:(1H-indol-3-yl)-Acetic acid

16:1H-indol-3-Ylacetate

17:1H-indol-3-Ylacetic acid

18:1H-Indole-3-acetate

19:1H-Indole-3-acetic acid

20:2-(1H-indol-3-yl)Acetate

21:2-(1H-indol-3-yl)Acetic acid

22:2-(3-Indolyl)acetate

23:2-(3-Indolyl)acetic acid

24:3-(Carboxymethyl)indole

25:3-IAA

26:3-Indole-acetic acid

27:3-Indoleacetate

28:3-Indoleacetic acid

29:3-Indolylacetate

30:3-Indolylacetic acid

31:alpha-indol-3-yl-Acetic acid

32:b-Indoleacetate

33:b-Indoleacetic acid

34:b-Indolylacetate

35:b-Indolylacetic acid

36:beta-Indole-3-acetic acid

37:beta-Indoleacetate

38:beta-Indoleacetic acid

39:beta-Indolylacetate

40:beta-Indolylacetic acid

41:indol-3-Ylacetate

42:indol-3-Ylacetic acid

43:Indolyl-3-acetate

44:Indolyl-3-acetic acid

45:Indolylacetate

46:Indolylacetic acid

47:Kyselina 3-indolyloctova

48:Rhizopin

49:Rhizopon a

50:Skatole carboxylate

51:Skatole carboxylic acid

52:Indoleacetic acid, calcium salt

53:Indoleacetic acid, monopotassium salt

54:Indoleacetic acid, monosodium salt

55:IES CPD

56:Indole acetic acid

57:Indoleacetic acid, alpha-(14)C-labeled

58:(R,R)-3,3'-Dithiobis(2-aminopropanoic acid)

59:(R-(R*,r*))-3,3'-dithiobis(2-aminopropanoic acid)

60:3,3'-Dithiobis-L-alanine

61:beta,Beta'-diamino-beta,beta'-dicarboxydiethyl disulfide

62:beta,Beta'-dithiodialanine

63:Bis(beta-amino-beta-carboxyethyl) disulfide

64:e921

65:L-alpha-Diamino-beta-dithiolactic acid

66:L-Dicysteine

67:Oxidized L-cysteine

68:(R,R)-3,3'-Dithiobis(2-aminopropanoate)

69:(R-(R*,r*))-3,3'-dithiobis(2-aminopropanoate)

70:b,Beta'-diamino-b,beta'-dicarboxydiethyl disulfide

71:b,Beta'-diamino-b,beta'-dicarboxydiethyl disulphide

72:beta,Beta'-diamino-beta,beta'-dicarboxydiethyl disulphide

73:Β,beta'-diamino-β,beta'-dicarboxydiethyl disulfide

74:Β,beta'-diamino-β,beta'-dicarboxydiethyl disulphide

75:b,Beta'-dithiodialanine

76:Β,beta'-dithiodialanine

77:Bis(b-amino-b-carboxyethyl) disulfide

78:Bis(b-amino-b-carboxyethyl) disulphide

79:Bis(beta-amino-beta-carboxyethyl) disulphide

80:Bis(β-amino-β-carboxyethyl) disulfide

81:Bis(β-amino-β-carboxyethyl) disulphide

82:L-a-Diamino-b-dithiolactate

83:L-a-Diamino-b-dithiolactic acid

84:L-alpha-Diamino-beta-dithiolactate

85:L-Α-diamino-β-dithiolactate

86:L-Α-diamino-β-dithiolactic acid

87:(-)-Cystine

88:(R-(R*,r*))-3,3'-dithiobis

89:2-Amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoate

90:2-Amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoic acid

91:2-Amino-3-[(2-amino-2-carboxyethyl)dithio]propanoate

92:2-Amino-3-[(2-amino-2-carboxyethyl)dithio]propanoic acid

93:3,3'-Dithiobis

94:3,3'-Dithiobis[2-amino-[R-(r*,r*)]-propanoate

95:3,3'-Dithiobis[2-amino-[R-(r*,r*)]-propanoic acid

96:3,3'-Dithiodialanine

97:b,B'-diamino-b,b'-dicarboxydiethyl disulfide

98:b,B'-dithiodialanine

99:beta,Beta'-dithiobisalanine

100:Bis(b-amino-beta-carboxyethyl) disulfide

101:Cysteine disulfide

102:Cystin

103:Cystine

104:Cystine acid

105:D(+)-3,3'-Dithiobis(2-aminopropanoate

106:D(+)-3,3'-Dithiobis(2-aminopropanoic acid

107:Dicysteine

108:Gelucystine

109:L-(-)-Cystine

110:L-Cysteine disulfide

111:L-Cystin

112:[R-(R*,r*)]-3,3'-dithiobis

113:L Cystine

114:Copper cystinate

115:(+)-Lactic acid

116:(S)-(+)-Lactic acid

117:(S)-2-Hydroxypropanoic acid

118:(S)-2-Hydroxypropionic acid

119:L-(+)-alpha-Hydroxypropionic acid

120:L-(+)-Lactic acid

121:L-Milchsaeure

122:L-Lactate

123:(+)-Lactate

124:(S)-(+)-Lactate

125:(S)-2-Hydroxypropanoate

126:(S)-2-Hydroxypropionate

127:L-(+)-a-Hydroxypropionate

128:L-(+)-a-Hydroxypropionic acid

129:L-(+)-alpha-Hydroxypropionate

130:L-(+)-Α-hydroxypropionate

131:L-(+)-Α-hydroxypropionic acid

132:L-(+)-Lactate

133:(alpha)-Lactate

134:(alpha)-Lactic acid

135:(S)-(+)-2-Hydroxypropanoate

136:(S)-(+)-2-Hydroxypropanoic acid

137:(S)-2-Hydroxy-propanoate

138:(S)-2-Hydroxy-propanoic acid

139:(S)-Lactate

140:(S)-Lactic acid

141:1-Hydroxyethane 1-carboxylate

142:1-Hydroxyethane 1-carboxylic acid

143:1-Hydroxyethanecarboxylate

144:1-Hydroxyethanecarboxylic acid

145:2-Hydroxypropanoate

146:2-Hydroxypropanoic acid

147:2-Hydroxypropionate

148:a-Hydroxypropanoate

149:a-Hydroxypropanoic acid

150:a-Hydroxypropionate

151:a-Hydroxypropionic acid

152:alpha-Hydroxypropanoate

153:alpha-Hydroxypropanoic acid

154:alpha-Hydroxypropionate

155:alpha-Hydroxypropionic acid

156:L-(+)- Lactic acid

157:L-2-Hydroxypropanoate

158:L-2-Hydroxypropanoic acid

159:Lactate

160:Lactic acid

161:Milk acid

162:Sarcolactic acid

163:2-Hydroxypropionic acid

164:D-Lactic acid

165:D Lactic acid

166:Lactate, ammonium

167:2 Hydroxypropanoic acid

168:2 Hydroxypropionic acid

169:Ammonium lactate

170:L Lactic acid

171:9-beta-D-Ribofuranosyl-9H-purin-6-ol

172:9-beta-D-Ribofuranosylhypoxanthine

173:Hypoxanthine D-riboside

174:Hypoxanthosine

175:i

176:Inosin

177:Inosina

178:Inosinum

179:Inotin

180:9-b-D-Ribofuranosyl-9H-purin-6-ol

181:9-Β-D-ribofuranosyl-9H-purin-6-ol

182:9-b-D-Ribofuranosylhypoxanthine

183:9-Β-D-ribofuranosylhypoxanthine

184:(-)-Inosine

185:1,9-Dihydro-9-b-D-ribofuranosyl-6H-purin-6-one

186:1,9-Dihydro-9-beta-D-ribofuranosyl-6H-purin-6-one

187:1,9-Dihydro-9-beta-delta-ribofuranosyl-6H-purin-6-one

188:9-b-D-Ribofuranosyl-hypoxanthine

189:9-beta-D-Ribofuranosyl-hypoxanthine

190:9-beta-delta-Ribofuranosyl-hypoxanthine

191:9-beta-delta-Ribofuranosylhypoxanthine

192:9beta-D-Ribofuranosylhypoxanthine

193:9beta-delta-Ribofuranosylhypoxanthine

194:Atorel

195:beta-D-Ribofuranoside hypoxanthine-9

196:beta-delta-Ribofuranoside hypoxanthine-9

197:beta-Inosine

198:HXR

199:Hypoxanthine 9-beta-D-ribofuranoside

200:Hypoxanthine 9-beta-delta-ribofuranoside

201:Hypoxanthine nucleoside

202:Hypoxanthine ribonucleoside

203:Hypoxanthine riboside

204:Hypoxanthine-9 beta-D-ribofuranoside

205:Hypoxanthine-9 beta-delta-ribofuranoside

206:Hypoxanthine-9-beta-D-ribofuranoside

207:Hypoxanthine-9-beta-delta-ribofuranoside

208:Hypoxanthine-9-D-ribofuranoside

209:Hypoxanthine-9-delta-ribofuranoside

210:Hypoxanthine-ribose

211:Indole-3-carboxaldehyde

212:Ino

213:Inosie

214:Iso-prinosine

215:Oxiamin

216:Panholic-L

217:Pantholic-L

218:Ribonosine

219:Selfer

220:Trophicardyl

221:(2S)-6-(Acetylamino)-2-aminohexanoic acid

222:N(6)-ACETYLLYSINE

223:N(zeta)-Acetyllysine

224:N-epsilon-Acetyl-L-lysine

225:N-Epsilon-Acetyllysine

226:N(epsilon)-Acetyl-L-lysine

227:N(zeta)-Acetyl-L-lysine

228:(2S)-6-(Acetylamino)-2-aminohexanoate

229:N(Z)-Acetyllysine

230:N(Ζ)-acetyllysine

231:N(Z)-Acetyl-L-lysine

232:N(Ζ)-acetyl-L-lysine

233:e-Acetyl-L-lysine

234:e-N-Acetyl-L-lysine

235:e-N-Acetyllysine

236:epsilon-Acetyl-L-lysine

237:epsilon-N-Acetyl-L-lysine

238:epsilon-N-Acetyllysine

239:L-e-N-Acetyllysine

240:L-epsilon-N-Acetyllysine

241:N-e-Acetyl-L-lysine

242:N-e-Acetyllysine

243:N6-Acetyllysine

244:Ne-acetyl-L-lysine

245:Ne-acetyllysine

246:Omega-N-acetyl-L-lysine

247:W-N-Acetyl-L-lysine

248:N(6)-Acetyllsine

249:Omega-acetyllsine

250:beta-Alanyl-3-methyl-L-histidine

251:beta-Alanyl-N(pai)-methyl-L-histidine

252:b-Alanyl-3-methyl-L-histidine

253:Β-alanyl-3-methyl-L-histidine

254:b-Alanyl-N(pai)-methyl-L-histidine

255:Β-alanyl-N(pai)-methyl-L-histidine

256:L-Anserine

257:L-N-b-Alanyl-3-methyl-histidine

258:L-N-beta-Alanyl-3-methyl-histidine

259:N-b-Alanyl-3-methyl-L-histidine

260:N-beta-Alanyl-3-methyl-L-histidine

261:Balanine

262:Beta Alanyl 3 methylhistidine

263:Beta-Alanyl-3-methylhistidine

264:Ophidine

265:Indoleacetic acid

266:3-(Carboxymethyl)-1H-indole

267:3-Indolylmethylcarboxylic acid

268:alpha-IAA

269:α-IAA

270:beta-IAA

271:β-IAA

272:β-Indoleacetic acid

化学式
C10H9NO2
平均分子量
175.184
等位分子量
175.063328537
化学名称
2-(1H-indol-3-yl)acetic acid
传统名称
β-indole-3-acetic acid
CAS 登记号
87-51-4
代谢物结构字符串
OC(=O)CC1=CNC2=C1C=CC=C2
inchi标识符
InChI=1S/C10H9NO2/c12-10(13)5-7-6-11-9-4-2-1-3-8(7)9/h1-4,6,11H,5H2,(H,12,13)
印记键
SEOVTRFCIGRIMH-UHFFFAOYSA-N
分类学
description: belongs to the class of organic compounds known as indole-3-acetic acid derivatives. Indole-3-acetic acid derivatives are compounds containing an acetic acid (or a derivative) linked to the C3 carbon atom of an indole.

description:Indole-3-acetic acid derivatives

kingdom:Organic compounds

super_class:Organoheterocyclic compounds

class:Indoles and derivatives

sub_class:Indolyl carboxylic acids and derivatives

molecular_framework:Aromatic heteropolycyclic compounds

1:3-alkylindoles

2:Azacyclic compounds

3:Benzenoids

4:Carbonyl compounds

5:Carboxylic acids

6:Heteroaromatic compounds

7:Hydrocarbon derivatives

8:Monocarboxylic acids and derivatives

9:Organic oxides

10:Organonitrogen compounds

11:Organopnictogen compounds

12:Substituted pyrroles

13:3-alkylindole

14:Aromatic heteropolycyclic compound

15:Azacycle

16:Benzenoid

17:Carbonyl group

18:Carboxylic acid

19:Carboxylic acid derivative

20:Heteroaromatic compound

21:Hydrocarbon derivative

22:Indole

23:Indole-3-acetic acid derivative

24:Monocarboxylic acid or derivatives

25:Organic nitrogen compound

26:Organic oxide

27:Organic oxygen compound

28:Organonitrogen compound

29:Organooxygen compound

30:Organopnictogen compound

31:Pyrrole

32:Substituted pyrrole

33:Auxins

34:Indole alkaloids

35:indole-3-acetic acids

36:monocarboxylic acid

本体论
term:Physiological effect

definition:The effect on an organism physiology, resulting from its exposure to a chemical.

parent_id:

level:1

type:parent

term:Health effect

definition:A health condition or observation associated with a stimuli or with a biological activity of a chemical.

parent_id:7693

*level:2

type:parent

term:Observation

definition:A short term health effect which reflects the reponse of the body to stimuli or is a symptom of a disease or condition; also includes health status which reflects stage in life.

parent_id:7694

**level:3

type:parent

term:Eye irritation

definition:

parent_id:7717

***level:4

type:child

term:Bleeding

definition:

parent_id:7717

***level:4

type:child

term:Tooth Decay

definition:

parent_id:7717

***level:4

type:child

term:Investigations

definition:The act or process of a systematic and thorough examination; research, study; the process of inquiring into or following up, intended to develop facts. (nci).

parent_id:7717

***level:4

type:parent

term:Health condition

definition:A health effect that consists on short or long-term disease, condition, disorder, syndrome or constant abnormality.

parent_id:7694

**level:3

type:parent

term:Irritable bowel syndrome

definition:A syndrome that is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause. (do).

parent_id:7695

***level:4

type:child

synonym:Ibs

term:Kidney disease

definition:A urinary system disease that is located in the kidney. (do).

parent_id:7695

***level:4

type:child

synonym:Renal disease

synonym:Nephropathy

term:Coma

definition:A state of profound unconsciousness associated with markedly depressed cerebral activity. Causes include central nervous system damage, intoxication, and metabolic abnormalities.

parent_id:7695

***level:4

type:child

term:Hartnup disease

definition:An amino acid metabolic disorder that is caused by abnormalities of the renal tubules and is characterized especially by aminoaciduria involving only monocarboxylic monoamines, a dry red scaly rash, and episodic muscular incoordination due to the effects of the disease on the cerebellum. (do).

parent_id:7695

***level:4

type:child

synonym:Hartnup disorder

term:Psychosis

definition:A mental disorder characterized by personality change, impaired functioning, and loss of touch with reality. (NCI)

parent_id:7695

***level:4

type:child

term:Uremia

definition:A disorder characterized by accummulation of solutes in the blood of people with chronic kidney disease. (do).

parent_id:7695

***level:4

type:child

synonym:Uraemia

term:Nervous system disorders

definition:Any disorder (non-neoplastic or neoplastic) that affects the brain, spinal cord, or peripheral nerves.

parent_id:7695

***level:4

type:parent

term:Renal and urinary disorders

definition:Any disorder that affects the kidneys and the urologic system.

parent_id:7695

***level:4

type:parent

term:Psychiatric disorders

definition:A group of disorders characterized by behavioral and/or psychological abnormalities, often accompanied by physical symptoms. the symptoms may cause clinically significant distress or impairment in social and occupational areas of functioning. representative examples include anxiety disorders, cognitive disorders, mood disorders and schizophrenia. (nci).

parent_id:7695

***level:4

type:parent

term:Cardiac disorders

definition:Any disorder that affects the heart.

parent_id:7695

***level:4

type:parent

term:Gastrointestinal disorders

definition:Any disorder (non-neoplastic or neoplastic) that affects the gastrointestinal tract.

parent_id:7695

***level:4

type:parent

term:Infections and infestations

definition:Any disorder resulting from the presence and activity of a microbial, viral, or parasitic agent. it can be transmitted by direct or indirect contact. (nci).

parent_id:7695

***level:4

type:parent

term:Disposition

definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.

parent_id:

level:1

type:parent

term:Route of exposure

definition:A mean by which a chemical agent comes in contact with an organism, either under intended or unintended circumstances.

parent_id:7724

*level:2

type:parent

term:Parenteral

definition:Chemical exposure via the a route other than the alimentary canal.

parent_id:7743

**level:3

type:parent

term:Dermal

definition:Chemical exposure by contact with the dermis or a cuticle or cornified region of the epidermis.

parent_id:7745

***level:4

type:child

synonym:Topical

synonym:Skin contact

synonym:Cutaneous (related but nor necessarily exact synonym)

synonym:Transdermal

term:Enteral

definition:Chemical exposure via the alimentary canal (mouth to anus).

parent_id:7743

**level:3

type:parent

term:Ingestion

definition:Chemical exposure facilitated by entry through the mouth.

parent_id:7744

***level:4

type:child

synonym:Digestion

term:Source

definition:Natural or synthetic origin of a chemical.

parent_id:7724

*level:2

type:parent

term:Endogenous

definition:

parent_id:7735

**level:3

type:child

term:Food

definition:

parent_id:7735

**level:3

type:child

term:Biological

definition:A living organism (species or a higher taxonomy rank), in which a chemical can be found.

parent_id:7735

**level:3

type:parent

term:Animal

definition:A living organism belonging to the kingdom animalia. it feeds on organic matter, typically having specialized sense organs and nervous system and able to respond rapidly to stimuli.

parent_id:7736

***level:4

type:child

synonym:Fauna

term:Microbe

definition:A living organism that is of a microscopic scale, either single-celled or a cluster of cells.

parent_id:7736

***level:4

type:parent

term:Plant

definition:A living organism belonging to the kingdom plantea. typically, it grows in a permanent site, absorbs water and inorganic substances through its roots, and synthesizes nutrients in its leaves by photosynthesis using the green pigment chlorophyll. examples incude trees, shrubs, herbs, grasses, ferns, and mosses.

parent_id:7736

***level:4

type:parent

synonym:Flora

term:Biological location

definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.

parent_id:7724

*level:2

type:parent

term:Tissue and substructures

definition:An anatomical organizational level including multiple cells yet not comprising a complete organ .

parent_id:7725

**level:3

type:parent

term:Placenta

definition:An organ present in some vertebrates during embryonic gestation that surrounds the fetus and provides it with nutrients and oxygen, facilitates gas and waste exchange between the fetus and mother, and provides parasitic cloaking from the mother's immune system by excretion of neurokinin b. (nci).

parent_id:7729

***level:4

type:child

term:Cell and elements

definition:An anatomical organizational level comprising of a single cell (or a fragment in some exceptions). a cell is defined by its type or function. it is the smallest unit of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid.

parent_id:7725

**level:3

type:parent

term:Element

definition:

parent_id:7732

***level:4

type:parent

term:Cell

definition:

parent_id:7732

***level:4

type:parent

term:Organ and components

definition:An anatomical organizational level including multiple tissues or substructures, which enables a common biological function.

parent_id:7725

**level:3

type:parent

term:Spinal cord

definition:The portion of the central nervous system that lies within the vertebral canal and from which the spinal nerves emerge. (nci).

parent_id:7727

***level:4

type:child

term:Brain

definition:An organ composed of grey and white matter that is the center for intelligence and reasoning. it is protected by the bony cranium. (nci).

parent_id:7727

***level:4

type:child

term:Hypothalamus

definition:A small region of the brain composed of multiple nuclei and located underneath the thalamus.

parent_id:7727

***level:4

type:child

term:Liver

definition:An abdominal organ that has variable lobation which are composed mainly of hepatic lobules. (nci).

parent_id:7727

***level:4

type:child

term:Kidney

definition:The organs of the urinary tract located in the retroperitoneal cavity adjacent to the spine and composed of the renal cortex and the renal medulla. (nci).

parent_id:7727

***level:4

type:child

synonym:Kidneys

term:Biofluid and excreta

definition:A liquid, semi-solid or solid material originating in the body.

parent_id:7725

**level:3

type:parent

term:Saliva

definition:The watery fluid in the mouth made by the salivary glands. saliva moistens food to help digestion and it helps protect the mouth against infections. (nci).

parent_id:7731

***level:4

type:child

term:Feces

definition:The material discharged from the bowel during defecation. It consists of undigested food, intestinal mucus, epithelial cells, and bacteria.

parent_id:7731

***level:4

type:child

synonym:Fecal

synonym:Stool

synonym:Faecal

synonym:Faeces

term:Urine

definition:Excretion in liquid state processed by the kidney.

parent_id:7731

***level:4

type:child

term:Blood

definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.

parent_id:7731

***level:4

type:child

term:Cerebrospinal fluid

definition:The fluid that is contained within the brain ventricles, the subarachnoid space and the central canal of the spinal cord. (nci).

parent_id:7731

***level:4

type:child

synonym:Csf

term:Subcellular

definition:An anatomical organizational level including a component within a biological cell .

parent_id:7725

**level:3

type:parent

term:Cytoplasm

definition:The portion of the cell contained within the plasma membrane but excluding the nucleus.

parent_id:7730

***level:4

type:child

synonym:Cytoplasma

term:Mitochondria

definition:

parent_id:7730

***level:4

type:child

term:Process

definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.

parent_id:

level:1

type:parent

term:Naturally occurring process

definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.

parent_id:7659

*level:2

type:parent

term:Biological process

definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.

parent_id:7660

**level:3

type:parent

term:Biochemical pathway

definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.

parent_id:7661

***level:4

type:parent

term:Role

definition:The purpose or function assumed by a chemical, either naturally or as intended by humans .

parent_id:

level:1

type:parent

term:Industrial application

definition:The assumed function of a chemical utilized by human.

parent_id:7671

*level:2

type:parent

term:Pharmaceutical industry

definition:A pharmacologic activity for which a chemical substance is utilized owing to its biological role.

parent_id:7678

**level:3

type:parent

term:Pharmaceutical

definition:

parent_id:7679

***level:4

type:child

term:Biological role

definition:The biological function of a chemical. the biological role answers the question how a chemical is involved in molecular processes in an organism. this can include biochemical effects of non-endogenous chemicals, which are also assigned an industrial application such as pharmaceuticals. the biological role is limited to cellular levls, and will not include role at system process level, such as a chemical which has a role in a disease.

parent_id:7671

*level:2

type:parent

term:Drug metabolite

definition:

parent_id:7672

**level:3

type:child

term:Waste product

definition:A chemical that is generated in a metabolic process and is destined to be excreted from the body. It commonly consists of water, nitrogenous compounds or carbon dioxide and can be a metabolic byproduct or a degradation product (such as urobilin metabolised from bilirubin which is a degradation product of hemoglobin).

parent_id:7672

**level:3

type:child

状态
Solid
实验性质
1:

kind:water_solubility

value:1.5 mg/mL

source:

2:

kind:logp

value:1.41

source:HANSCH,C ET AL. (1995)

3:

kind:melting_point

value:168.5 °C

source:

预测性质
1:

kind:logp

value:1.87

source:ALOGPS

2:

kind:logs

value:-2.10

source:ALOGPS

3:

kind:solubility

value:1.38 g/L

source:ALOGPS

4:

kind:logp

value:1.71

source:ChemAxon

5:

kind:pka_strongest_acidic

value:4.66

source:ChemAxon

6:

kind:iupac

value:2-(1H-indol-3-yl)acetic acid

source:ChemAxon

7:

kind:average_mass

value:175.184

source:ChemAxon

8:

kind:mono_mass

value:175.063328537

source:ChemAxon

9:

kind:smiles

value:OC(=O)CC1=CNC2=C1C=CC=C2

source:ChemAxon

10:

kind:formula

value:C10H9NO2

source:ChemAxon

11:

kind:inchi

value:InChI=1S/C10H9NO2/c12-10(13)5-7-6-11-9-4-2-1-3-8(7)9/h1-4,6,11H,5H2,(H,12,13)

source:ChemAxon

12:

kind:inchikey

value:SEOVTRFCIGRIMH-UHFFFAOYSA-N

source:ChemAxon

13:

kind:polar_surface_area

value:53.09

source:ChemAxon

14:

kind:refractivity

value:48.45

source:ChemAxon

15:

kind:polarizability

value:17.74

source:ChemAxon

16:

kind:rotatable_bond_count

value:2

source:ChemAxon

17:

kind:acceptor_count

value:2

source:ChemAxon

18:

kind:donor_count

value:2

source:ChemAxon

19:

kind:physiological_charge

value:-1

source:ChemAxon

20:

kind:formal_charge

value:0

source:ChemAxon

21:

kind:number_of_rings

value:2

source:ChemAxon

22:

kind:bioavailability

value:Yes

source:ChemAxon

23:

kind:rule_of_five

value:Yes

source:ChemAxon

24:

kind:ghose_filter

value:Yes

source:ChemAxon

25:

kind:veber_rule

value:No

source:ChemAxon

26:

kind:mddr_like_rule

value:No

source:ChemAxon

1:

type:Specdb::EiMs

spectrum_id:597

2:

type:Specdb::NmrOneD

spectrum_id:1176

3:

type:Specdb::NmrOneD

spectrum_id:2682

4:

type:Specdb::NmrOneD

spectrum_id:3368

5:

type:Specdb::NmrOneD

spectrum_id:4916

6:

type:Specdb::NmrOneD

spectrum_id:4917

7:

type:Specdb::NmrTwoD

spectrum_id:993

8:

type:Specdb::NmrTwoD

spectrum_id:1201

9:

type:Specdb::CMs

spectrum_id:450

10:

type:Specdb::CMs

spectrum_id:451

11:

type:Specdb::CMs

spectrum_id:452

12:

type:Specdb::CMs

spectrum_id:453

13:

type:Specdb::CMs

spectrum_id:454

14:

type:Specdb::CMs

spectrum_id:455

15:

type:Specdb::CMs

spectrum_id:1670

16:

type:Specdb::CMs

spectrum_id:1705

17:

type:Specdb::CMs

spectrum_id:2773

18:

type:Specdb::CMs

spectrum_id:27006

19:

type:Specdb::CMs

spectrum_id:30194

20:

type:Specdb::CMs

spectrum_id:30296

21:

type:Specdb::CMs

spectrum_id:30297

22:

type:Specdb::CMs

spectrum_id:30298

23:

type:Specdb::CMs

spectrum_id:30899

24:

type:Specdb::CMs

spectrum_id:30900

25:

type:Specdb::CMs

spectrum_id:31064

26:

type:Specdb::CMs

spectrum_id:31065

27:

type:Specdb::CMs

spectrum_id:32263

28:

type:Specdb::CMs

spectrum_id:37352

29:

type:Specdb::CMs

spectrum_id:132787

30:

type:Specdb::CMs

spectrum_id:140521

31:

type:Specdb::MsMs

spectrum_id:319

32:

type:Specdb::MsMs

spectrum_id:320

33:

type:Specdb::MsMs

spectrum_id:321

34:

type:Specdb::MsMs

spectrum_id:3569

35:

type:Specdb::MsMs

spectrum_id:3570

36:

type:Specdb::MsMs

spectrum_id:3571

37:

type:Specdb::MsMs

spectrum_id:3572

38:

type:Specdb::MsMs

spectrum_id:3573

39:

type:Specdb::MsMs

spectrum_id:3574

40:

type:Specdb::MsMs

spectrum_id:3575

41:

type:Specdb::MsMs

spectrum_id:3576

42:

type:Specdb::MsMs

spectrum_id:3577

43:

type:Specdb::MsMs

spectrum_id:3578

44:

type:Specdb::MsMs

spectrum_id:3579

45:

type:Specdb::MsMs

spectrum_id:3586

46:

type:Specdb::MsMs

spectrum_id:3587

47:

type:Specdb::MsMs

spectrum_id:3588

48:

type:Specdb::MsMs

spectrum_id:3589

49:

type:Specdb::MsMs

spectrum_id:12899

50:

type:Specdb::MsMs

spectrum_id:12900

51:

type:Specdb::MsMs

spectrum_id:12901

52:

type:Specdb::MsMs

spectrum_id:19571

53:

type:Specdb::MsMs

spectrum_id:19572

54:

type:Specdb::MsMs

spectrum_id:19573

55:

type:Specdb::MsMs

spectrum_id:20546

光谱
生物学性质
1:

cellular:(1):Cytoplasm

cellular:(2):Mitochondria

2:

biospecimen:(1):Blood

biospecimen:(2):Cerebrospinal Fluid (CSF)

biospecimen:(3):Feces

biospecimen:(4):Saliva

biospecimen:(5):Urine

3:

tissue:(1):Brain

tissue:(2):Fibroblasts

tissue:(3):Kidney

tissue:(4):Liver

tissue:(5):Placenta

tissue:(6):Platelet

4:

[1]:

name:Tryptophan metabolism

smpdb_id:

kegg_map_id:map00380

正常浓度
1:

biospecimen:Blood

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

2:

biospecimen:Blood

concentration_value:2.85 +/- 1.71

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

3:

biospecimen:Blood

concentration_value:0.100 +/- 0.100

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

4:

biospecimen:Blood

concentration_value:0.05 (0.0-0.118)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

5:

biospecimen:Blood

concentration_value:0.05 (0.0- 0.1)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

6:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.03 (0.005 - 0.3)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

7:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.0359 +/- 0.0150

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Male

subject_condition:Normal

8:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.0280 +/- 0.0127

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

9:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.339 +/- 0.0743

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

10:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.0251 +/- 0.00211

concentration_units:uM

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

11:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

12:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

13:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

14:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

15:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

16:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

17:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

18:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

19:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

20:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

21:

biospecimen:Saliva

concentration_value:0.859 +/- 2.16

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

22:

biospecimen:Saliva

concentration_value:1.08 +/- 1.40

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

23:

biospecimen:Saliva

concentration_value:0.151 +/- 0.478

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

24:

biospecimen:Saliva

concentration_value:3.14 +/- 3.16

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

25:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

26:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

27:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

28:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

29:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

30:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

31:

biospecimen:Urine

concentration_value:10.213 +/- 8.547

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

32:

biospecimen:Urine

concentration_value:0.03-1.95

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

33:

biospecimen:Urine

concentration_value:0.22(0.06-1.18)

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Female

subject_condition:Normal

34:

biospecimen:Urine

concentration_value:0.28(0.02-1.98)

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Male

subject_condition:Normal

35:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

36:

biospecimen:Urine

concentration_value:41.027 +/- 21.106

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

37:

biospecimen:Urine

concentration_value:24.75 +/- 16.978

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

38:

biospecimen:Urine

concentration_value:3.4 (1.8-6.2)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

39:

biospecimen:Urine

concentration_value:2.0 +/- 1.0

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

40:

biospecimen:Urine

concentration_value:0.944 (0.457-1.294)

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

41:

biospecimen:Urine

concentration_value:1.5-2.8

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

42:

biospecimen:Urine

concentration_value:5.2 (0.1-31.0)

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

43:

biospecimen:Urine

concentration_value:4.6 (0.1-5.7)

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

44:

biospecimen:Urine

concentration_value:3.4 (1.3-12.3)

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Both

subject_condition:Normal

45:

biospecimen:Urine

concentration_value:2.8 (0.1-5.5)

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Both

subject_condition:Normal

46:

biospecimen:Urine

concentration_value:3.8 (1.1-8.4)

concentration_units:umol/mmol creatinine

subject_age:Adolescent (13-18 years old)

subject_sex:Both

subject_condition:Normal

47:

biospecimen:Urine

concentration_value:1.5-2.6

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

48:

biospecimen:Urine

concentration_value:5.6 (5.5 - 5.8)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

49:

biospecimen:Urine

concentration_value:2.6(0.6-5.4)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

50:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

异常浓度
1:

biospecimen:Blood

concentration_value:13.70 +/- 12.56

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:uremia

2:

biospecimen:Blood

concentration_value:5 +/- 3.200

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Uremia

3:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.0251 +/- 0.00240

concentration_units:uM

patient_age:Not Specified

patient_sex:Not Specified

patient_information:anorexia

4:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.0315 +/- 0.00748

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:autism

5:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.0299 +/- 0.00280

concentration_units:uM

patient_age:Not Specified

patient_sex:Not Specified

patient_information:depressive

6:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.0247 +/- 0.00360

concentration_units:uM

patient_age:Not Specified

patient_sex:Not Specified

patient_information:Mania

7:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.0337 +/- 0.00457

concentration_units:uM

patient_age:Not Specified

patient_sex:Not Specified

patient_information:Retarded depression

8:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal Cancer

9:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Not Specified

patient_sex:Not Specified

patient_information:Cryptosporidium infection

10:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal Cancer

11:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

12:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Enthesitis-related arthritis

13:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Tooth Decay

14:

biospecimen:Saliva

concentration_value:0.571 +/- 0.992

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Dental caries

15:

biospecimen:Urine

concentration_value:11.58 +/- 10.413

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Eosinophilic esophagitis

16:

biospecimen:Urine

concentration_value:45.731 +/- 33.914

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Eosinophilic esophagitis

17:

biospecimen:Urine

concentration_value:64.967 +/- 50.993

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Gastroesophageal reflux disease

18:

biospecimen:Urine

concentration_value:42.755 +/- 34.674

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Eosinophilic esophagitis

19:

biospecimen:Urine

concentration_value:33.666 +/- 20.269

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Gastroesophageal reflux disease

20:

biospecimen:Urine

concentration_value:3.0 (2.5-6.8)

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Irritable bowel syndrome (IBS)

21:

biospecimen:Urine

concentration_value:1.636-2.0930

concentration_units:umol/mmol creatinine

patient_age:Children (1-13 years old)

patient_sex:Female

patient_information:Tryptophanuria with dwarfism

22:

biospecimen:Urine

concentration_value:6.165

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

23:

biospecimen:Urine

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Bladder cancer

24:

biospecimen:Urine

concentration_value:3.5 +/- 0.33

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Appendicitis

25:

biospecimen:Urine

concentration_value:3.1 +/- 0.14

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Appendicitis

疾病参考
1:

name:Uremia

omim_id:

[1]:

reference_text:Canepa A, Filho JC, Gutierrez A, Carrea A, Forsberg AM, Nilsson E, Verrina E, Perfumo F, Bergstrom J: Free amino acids in plasma, red blood cells, polymorphonuclear leukocytes, and muscle in normal and uraemic children. Nephrol Dial Transplant. 2002 Mar;17(3):413-21.

pubmed_id:11865086

[2]:

reference_text:Fujita T, Amuro Y, Hada T, Higashino K: Plasma levels of pipecolic acid, both L- and D-enantiomers, in patients with chronic liver diseases, especially hepatic encephalopathy. Clin Chim Acta. 1999 Sep;287(1-2):99-109.

pubmed_id:10509899

[3]:

reference_text:Niwa T, Takeda N, Yoshizumi H: RNA metabolism in uremic patients: accumulation of modified ribonucleosides in uremic serum. Technical note. Kidney Int. 1998 Jun;53(6):1801-6.

pubmed_id:9607216

[4]:

reference_text:Ishiwata S, Itoh K, Yamaguchi T, Ishida N, Mizugaki M: Comparison of serum and urinary levels of modified nucleoside, 1-methyladenosine, in cancer patients using a monoclonal antibody-based inhibition ELISA. Tohoku J Exp Med. 1995 May;176(1):61-8.

pubmed_id:7482520

[5]:

reference_text:Kai M, Miyazaki T, Ohkura Y: High-performance liquid chromatographic measurement of guanidino compounds of clinical importance in human urine and serum by pre-column fluorescence derivatization using benzoin. J Chromatogr. 1984 Nov 28;311(2):257-66.

pubmed_id:6520173

[6]:

reference_text:Duranton F, Cohen G, De Smet R, Rodriguez M, Jankowski J, Vanholder R, Argiles A: Normal and pathologic concentrations of uremic toxins. J Am Soc Nephrol. 2012 Jul;23(7):1258-70. doi: 10.1681/ASN.2011121175. Epub 2012 May 24.

pubmed_id:22626821

[7]:

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name:Colorectal cancer

omim_id:114500

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6:

name:Tooth Decay

omim_id:

[1]:

reference_text:Liebsch C, Pitchika V, Pink C, Samietz S, Kastenmuller G, Artati A, Suhre K, Adamski J, Nauck M, Volzke H, Friedrich N, Kocher T, Holtfreter B, Pietzner M: The Saliva Metabolome in Association to Oral Health Status. J Dent Res. 2019 Jun;98(6):642-651. doi: 10.1177/0022034519842853. Epub 2019 Apr 26.

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7:

name:Appendicitis

omim_id:

[1]:

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8:

name:Irritable bowel syndrome

omim_id:

[1]:

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[7]:

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9:

name:Eosinophilic esophagitis

omim_id:610247

[1]:

reference_text:Mordechai, Hien, and David S. Wishart

pubmed_id:

10:

name:Tryptophanuria with dwarfism

omim_id:276100

[1]:

reference_text:TADA K, ITO H, WADA Y, ARAKAWA T: CONGENITAL TRYPTOPHANURIA WITH DWARFISM ("H" DISEASE-LIKE CLINICAL FEATURES WITHOUT INDICANURIA AND GENERALIZED AMINOACIDURIA):--A PROBABLY NEW INBORN ERROR OF TRYPTOPHAN METABOLISM. Tohoku J Exp Med. 1963 Jul 25;80:118-34.

pubmed_id:14055140

KEGG数据库编号
C00954
DrugBank数据库编号
DB07950
foodb数据库编号
FDB030920
ChemSpider数据库编号
780
公共化学化合物编号
802
PDB数据库编号
生物利益的化学实体数据库编号
16411
knapsack数据库编号
C00000100
维基百科编号
Indole-3-acetic_acid
代谢途径的数据库编号
INDOLE_ACETATE_AUXIN
苯酚资源管理器化合物数据库编号
比格数据库编号
梅林编号
虚拟机身份证编号
IND3AC
fbonto数据库编号
综合参考
Snyder, H. R.; Pilgrim, Frederick J. Preparation of 3-indoleacetic acid; new synthesis of tryptophol. Journal of the American Chemical Society (1948), 70 3770-1.
一般参考
1:

protein_accession:HMDBP00291

name:4-trimethylaminobutyraldehyde dehydrogenase

uniprot_id:P49189

gene_name:ALDH9A1

protein_type:Unknown

2:

protein_accession:HMDBP00293

name:Alpha-aminoadipic semialdehyde dehydrogenase

uniprot_id:P49419

gene_name:ALDH7A1

protein_type:Unknown

3:

protein_accession:HMDBP00294

name:Aldehyde dehydrogenase family 1 member A3

uniprot_id:P47895

gene_name:ALDH1A3

protein_type:Unknown

4:

protein_accession:HMDBP00295

name:Aldehyde dehydrogenase, mitochondrial

uniprot_id:P05091

gene_name:ALDH2

protein_type:Unknown

5:

protein_accession:HMDBP00296

name:Fatty aldehyde dehydrogenase

uniprot_id:P51648

gene_name:ALDH3A2

protein_type:Unknown

6:

protein_accession:HMDBP00297

name:Aldehyde dehydrogenase X, mitochondrial

uniprot_id:P30837

gene_name:ALDH1B1

protein_type:Unknown

蛋白质结合
1:

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pubmed_id:3500530

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pubmed_id:133735

6:

reference_text:Blennow K, Wallin A, Gottfries CG, Mansson JE, Svennerholm L: Concentration gradients for monoamine metabolites in lumbar cerebrospinal fluid. J Neural Transm Park Dis Dement Sect. 1993;5(1):5-15.

pubmed_id:7679905

7:

reference_text:Morgan WW, Grant RW: Increased rate of disappearance of serum probenecid in barbital dependent rats. Eur J Pharmacol. 1976 Dec;40(2):349-57.

pubmed_id:1033074

8:

reference_text:Jellinger K, Riederer P: Brain monoamines in metabolic (endotoxic) coma. A preliminary biochemical study in human postmortem material. J Neural Transm. 1977;41(4):275-86.

pubmed_id:925688

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pubmed_id:1689378

10:

reference_text:Kema IP, Meijer WG, Meiborg G, Ooms B, Willemse PH, de Vries EG: Profiling of tryptophan-related plasma indoles in patients with carcinoid tumors by automated, on-line, solid-phase extraction and HPLC with fluorescence detection. Clin Chem. 2001 Oct;47(10):1811-20.

pubmed_id:11568091

11:

reference_text:Bai F, Jones DC, Lau SS, Monks TJ: Serotonergic neurotoxicity of 3,4-(+/-)-methylenedioxyamphetamine and 3,4-(+/-)-methylendioxymethamphetamine (ecstasy) is potentiated by inhibition of gamma-glutamyl transpeptidase. Chem Res Toxicol. 2001 Jul;14(7):863-70.

pubmed_id:11453733

12:

reference_text:Ridges AP, Bishop FM, Lawton K, Goldberg IJ: Amine metabolism, thyroid function and response to clomipramine and maprotiline medication in depression. Postgrad Med J. 1980;56 Suppl 1:37-41.

pubmed_id:6156444

13:

reference_text:Raghuram TC, Krishnaswamy K: Serotonin metabolism is pellagra. Arch Neurol. 1975 Oct;32(10):708-10.

pubmed_id:1180737

14:

reference_text:Carling RS, Degg TJ, Allen KR, Bax ND, Barth JH: Evaluation of whole blood serotonin and plasma and urine 5-hydroxyindole acetic acid in diagnosis of carcinoid disease. Ann Clin Biochem. 2002 Nov;39(Pt 6):577-82.

pubmed_id:12564839

15:

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pubmed_id:7513511

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reference_text:Russo S, Boon JC, Kema IP, Willemse PH, den Boer JA, Korf J, de Vries EG: Patients with carcinoid syndrome exhibit symptoms of aggressive impulse dysregulation. Psychosom Med. 2004 May-Jun;66(3):422-5.

pubmed_id:15184706

17:

reference_text:Igari T, Shimamura T: Serotonin metabolism and its enzymic activities in joint diseases. Clin Orthop Relat Res. 1979 Mar-Apr;(139):232-49.

pubmed_id:455840

18:

reference_text:Bearcroft CP, Perrett D, Farthing MJ: Postprandial plasma 5-hydroxytryptamine in diarrhoea predominant irritable bowel syndrome: a pilot study. Gut. 1998 Jan;42(1):42-6.

pubmed_id:9505884

19:

reference_text:Ilkhanizadeh B, Owji AA, Tavangar SM, Vasei M, Tabei SM: Spot urine 5-hydroxy indole acetic acid and acute appendicitis. Hepatogastroenterology. 2001 May-Jun;48(39):609-13.

pubmed_id:11462886

20:

reference_text:Apak S, Kazez A, Ozel SK, Ustundag B, Akpolat N, Kizirgil A: Spot urine 5-hydroxyindoleacetic acid levels in the early diagnosis of acute appendicitis. J Pediatr Surg. 2005 Sep;40(9):1436-9.

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reference_text:WEISSBACH H, KING W, SJOERDSMA A, UDENFRIEND S: Formation of indole-3-acetic acid and tryptamine in animals: a method for estimation of indole-3-acetic acid in tissues. J Biol Chem. 1959 Jan;234(1):81-6.

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reference_text:Folkes LK, Wardman P: Oxidative activation of indole-3-acetic acids to cytotoxic species- a potential new role for plant auxins in cancer therapy. Biochem Pharmacol. 2001 Jan 15;61(2):129-36.

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reference_text:Duranton F, Cohen G, De Smet R, Rodriguez M, Jankowski J, Vanholder R, Argiles A: Normal and pathologic concentrations of uremic toxins. J Am Soc Nephrol. 2012 Jul;23(7):1258-70. doi: 10.1681/ASN.2011121175. Epub 2012 May 24.

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reference_text:Finegold SM, Molitoris D, Song Y, Liu C, Vaisanen ML, Bolte E, McTeague M, Sandler R, Wexler H, Marlowe EM, Collins MD, Lawson PA, Summanen P, Baysallar M, Tomzynski TJ, Read E, Johnson E, Rolfe R, Nasir P, Shah H, Haake DA, Manning P, Kaul A: Gastrointestinal microflora studies in late-onset autism. Clin Infect Dis. 2002 Sep 1;35(Suppl 1):S6-S16. doi: 10.1086/341914.

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