版本
5.0
创建日期
2005-11-16 15:48:42 UTC
更新日期
2021-09-14 15:20:01 UTC
登录号
HMDB0000191
地位
quantified
二级访问
HMDB00191

名称
L-Aspartic acid
描述
Aspartic acid (Asp), also known as L-aspartic acid or as aspartate, the name of its anion, is an alpha-amino acid. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). Amino acids are organic compounds that contain amino (–NH2) and carboxyl (–COOH) functional groups, along with a side chain (R group) specific to each amino acid. L-aspartic acid is one of 20 proteinogenic amino acids, i.e., the amino acids used in the biosynthesis of proteins. Aspartic acid is found in all organisms ranging from bacteria to plants to animals. It is classified as an acidic, charged (at physiological pH), aliphatic amino acid. In humans, aspartic acid is a nonessential amino acid derived from glutamic acid by enzymes using vitamin B6. However, in the human body, aspartate is most frequently synthesized through the transamination of oxaloacetate. A non-essential amino acid is an amino acid that can be synthesized from central metabolic pathway intermediates in humans and is not required in the diet. As its name indicates, aspartic acid is the carboxylic acid analog of asparagine. The D-isomer of aspartic acid (D-aspartic acid) is one of two D-amino acids commonly found in mammals. Aspartic acid was first discovered in 1827 by Auguste-Arthur Plisson and Étienne Ossian Henry by hydrolysis of asparagine, which had been isolated from asparagus juice in 1806. Aspartate has many biochemical roles. It is a neurotransmitter, a metabolite in the urea cycle and it participates in gluconeogenesis. It carries reducing equivalents in the malate-aspartate shuttle, which utilizes the ready interconversion of aspartate and oxaloacetate, which is the oxidized (dehydrogenated) derivative of malic acid. Aspartate donates one nitrogen atom in the biosynthesis of inosine, the precursor to the purine bases which are key to DNA biosynthesis. In addition, aspartic acid acts as a hydrogen acceptor in a chain of ATP synthase. Aspartic acid is a major excitatory neurotransmitter, which is sometimes found to be increased in epileptic and stroke patients. It is decreased in depressed patients and in patients with brain atrophy. As a neurotransmitter, aspartic acid may provide resistance to fatigue and thus lead to endurance, although the evidence to support this idea is not strong (Wikipedia). Aspartic acid supplements are being evaluated. Five grams can raise blood levels. Magnesium and zinc may be natural inhibitors of some of the actions of aspartic acid. Aspartic acid, when chemically coupled with the amino acid D-phenylalanine, is a part of a natural sweetener, aspartame. This sweetener is an advance in artificial sweeteners, and is probably safe in normal doses to all except phenylketonurics. Aspartic acid may be a significant immunostimulant of the thymus and can protect against some of the damaging effects of radiation. Aspartic acid is found in higher abundance in: oysters, luncheon meats, sausage meat, wild game, sprouting seeds, oat flakes, avocado, asparagus, young sugarcane, and molasses from sugar beets.
同义词
1:(S)-2-Aminobutanedioic acid

2:(S)-2-Aminosuccinic acid

3:2-Aminosuccinic acid

4:Asp

5:ASPARTIC ACID

6:D

7:L-Asparaginsaeure

8:L-Asp

9:(S)-2-Aminobutanedioate

10:(S)-2-Aminosuccinate

11:2-Aminosuccinate

12:ASPARTate

13:L-Aspartate

14:(+)-Aspartate

15:(+)-Aspartic acid

16:(2S)-Aspartate

17:(2S)-Aspartic acid

18:(L)-Aspartate

19:(L)-Aspartic acid

20:(R)-2-Aminosuccinate

21:(S)-(+)-Aspartate

22:(S)-(+)-Aspartic acid

23:(S)-Amino-butanedioate

24:(S)-Amino-butanedioic acid

25:(S)-Aminobutanedioate

26:(S)-Aminobutanedioic acid

27:(S)-Aspartate

28:(S)-Aspartic acid

29:2-Amino-3-methylsuccinate

30:2-Amino-3-methylsuccinic acid

31:alpha-Aminosuccinate

32:alpha-Aminosuccinic acid

33:Aminosuccinate

34:Asparagate

35:Asparagic acid

36:Asparaginate

37:Asparaginic acid

38:Asparatate

39:H-Asp-OH

40:L-(+)-Aspartate

41:L-(+)-Aspartic acid

42:L-Aminosuccinate

43:L-Aminosuccinic acid

44:L-Asparagate

45:L-Asparagic acid

46:L-Asparaginate

47:L-Asparaginic acid

48:(+-)-Aspartic acid

49:(R,S)-Aspartic acid

50:Aspartate, disodium

51:Aspartate, magnesium

52:Aspartate, monopotassium

53:Aspartic acid, dipotassium salt

54:Aspartic acid, hydrobromide

55:Aspartic acid, monopotassium salt

56:Aspartic acid, monosodium salt

57:Aspartic acid, potassium salt

58:L Aspartate

59:MG5Longoral

60:Potassium aspartate

61:Polysuccinimide

62:Ammonium aspartate

63:Aspartate, ammonium

64:Aspartate, calcium

65:Aspartate, monosodium

66:Aspartic acid, calcium salt

67:Aspartic acid, disodium salt

68:Aspartic acid, magnesium (1:1) salt, hydrochloride, trihydrate

69:Dipotassium aspartate

70:Disodium aspartate

71:Hydrochloride, aspartate magnesium

72:Monopotassium aspartate

73:Sodium aspartate

74:Aspartate, dipotassium

75:Aspartic acid, magnesium (2:1) salt

76:Aspartic acid, sodium salt

77:Hydrobromide aspartic acid

78:Magnesium aspartate

79:MG 5 Longoral

80:Monosodium aspartate

81:Aspartate magnesium hydrochloride

82:Aspartate, potassium

83:Aspartate, sodium

84:Aspartic acid, ammonium salt

85:Aspartic acid, hydrochloride

86:Aspartic acid, magnesium-potassium (2:1:2) salt

87:Calcium aspartate

88:Hydrochloride aspartic acid

89:L Aspartic acid

90:Magnesiocard

91:MG-5-Longoral

92:Poly-DL-succinimide

化学式
C4H7NO4
平均分子量
133.1027
等位分子量
133.037507717
化学名称
(2S)-2-aminobutanedioic acid
传统名称
L-aspartic acid
CAS 登记号
56-84-8
代谢物结构字符串
N[C@@H](CC(O)=O)C(O)=O
inchi标识符
InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1
印记键
CKLJMWTZIZZHCS-REOHCLBHSA-N
分类学
description: belongs to the class of organic compounds known as aspartic acid and derivatives. Aspartic acid and derivatives are compounds containing an aspartic acid or a derivative thereof resulting from reaction of aspartic acid at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.

description:Aspartic acid and derivatives

kingdom:Organic compounds

super_class:Organic acids and derivatives

class:Carboxylic acids and derivatives

sub_class:Amino acids, peptides, and analogues

molecular_framework:Aliphatic acyclic compounds

1:Amino acids

2:Carbonyl compounds

3:Carboxylic acids

4:Dicarboxylic acids and derivatives

5:Fatty acids and conjugates

6:Hydrocarbon derivatives

7:L-alpha-amino acids

8:Monoalkylamines

9:Organic oxides

10:Organopnictogen compounds

11:Aliphatic acyclic compound

12:Alpha-amino acid

13:Amine

14:Amino acid

15:Aspartic acid or derivatives

16:Carbonyl group

17:Carboxylic acid

18:Dicarboxylic acid or derivatives

19:Fatty acid

20:Hydrocarbon derivative

21:L-alpha-amino acid

22:Organic nitrogen compound

23:Organic oxide

24:Organic oxygen compound

25:Organonitrogen compound

26:Organooxygen compound

27:Organopnictogen compound

28:Primary aliphatic amine

29:Primary amine

30:Amino acids

31:Common amino acids

32:L-alpha-amino acid

33:aspartate family amino acid

34:aspartic acid

35:proteinogenic amino acid

本体论
term:Physiological effect

definition:The effect on an organism physiology, resulting from its exposure to a chemical.

parent_id:

level:1

type:parent

term:Health effect

definition:A health condition or observation associated with a stimuli or with a biological activity of a chemical.

parent_id:7693

*level:2

type:parent

term:Observation

definition:A short term health effect which reflects the reponse of the body to stimuli or is a symptom of a disease or condition; also includes health status which reflects stage in life.

parent_id:7694

**level:3

type:parent

term:Attachment loss

definition:

parent_id:7717

***level:4

type:child

term:Missing teeth

definition:

parent_id:7717

***level:4

type:child

term:Periodontal Probing Depth

definition:

parent_id:7717

***level:4

type:child

term:Health condition

definition:A health effect that consists on short or long-term disease, condition, disorder, syndrome or constant abnormality.

parent_id:7694

**level:3

type:parent

term:Schizophrenia

definition:A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness. (do).

parent_id:7695

***level:4

type:child

term:Epilepsy

definition:A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions. (do).

parent_id:7695

***level:4

type:child

synonym:Epileptic spasms

term:Growth hormone deficiency

definition:A finding based on laboratory test results that indicate abnormally low levels of growth hormone in a biological specimen. (nci ctcae).

parent_id:7695

***level:4

type:child

synonym:Ghd

term:Cirrhosis

definition:

parent_id:7695

***level:4

type:child

synonym:Liver cirrhosis

term:Disposition

definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.

parent_id:

level:1

type:parent

term:Route of exposure

definition:A mean by which a chemical agent comes in contact with an organism, either under intended or unintended circumstances.

parent_id:7724

*level:2

type:parent

term:Enteral

definition:Chemical exposure via the alimentary canal (mouth to anus).

parent_id:7743

**level:3

type:parent

term:Ingestion

definition:Chemical exposure facilitated by entry through the mouth.

parent_id:7744

***level:4

type:child

synonym:Digestion

term:Source

definition:Natural or synthetic origin of a chemical.

parent_id:7724

*level:2

type:parent

term:Endogenous

definition:

parent_id:7735

**level:3

type:child

term:Food

definition:

parent_id:7735

**level:3

type:child

term:Biological

definition:A living organism (species or a higher taxonomy rank), in which a chemical can be found.

parent_id:7735

**level:3

type:parent

term:Animal

definition:A living organism belonging to the kingdom animalia. it feeds on organic matter, typically having specialized sense organs and nervous system and able to respond rapidly to stimuli.

parent_id:7736

***level:4

type:child

synonym:Fauna

term:Plant

definition:A living organism belonging to the kingdom plantea. typically, it grows in a permanent site, absorbs water and inorganic substances through its roots, and synthesizes nutrients in its leaves by photosynthesis using the green pigment chlorophyll. examples incude trees, shrubs, herbs, grasses, ferns, and mosses.

parent_id:7736

***level:4

type:parent

synonym:Flora

term:Biological location

definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.

parent_id:7724

*level:2

type:parent

term:Tissue and substructures

definition:An anatomical organizational level including multiple cells yet not comprising a complete organ .

parent_id:7725

**level:3

type:parent

term:All tissues

definition:All tissues in the body of the organism.

parent_id:7729

***level:4

type:child

term:Placenta

definition:An organ present in some vertebrates during embryonic gestation that surrounds the fetus and provides it with nutrients and oxygen, facilitates gas and waste exchange between the fetus and mother, and provides parasitic cloaking from the mother's immune system by excretion of neurokinin b. (nci).

parent_id:7729

***level:4

type:child

term:Organ and components

definition:An anatomical organizational level including multiple tissues or substructures, which enables a common biological function.

parent_id:7725

**level:3

type:parent

term:Prostate

definition:The male reproductive accessory gland that produces prostatic fluid and is located adjacent to or around the urethra distal to the urinary bladder in mammals. (nci).

parent_id:7727

***level:4

type:child

synonym:Prostate gland

term:Biofluid and excreta

definition:A liquid, semi-solid or solid material originating in the body.

parent_id:7725

**level:3

type:parent

term:Urine

definition:Excretion in liquid state processed by the kidney.

parent_id:7731

***level:4

type:child

term:Saliva

definition:The watery fluid in the mouth made by the salivary glands. saliva moistens food to help digestion and it helps protect the mouth against infections. (nci).

parent_id:7731

***level:4

type:child

term:Feces

definition:The material discharged from the bowel during defecation. It consists of undigested food, intestinal mucus, epithelial cells, and bacteria.

parent_id:7731

***level:4

type:child

synonym:Fecal

synonym:Stool

synonym:Faecal

synonym:Faeces

term:Blood

definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.

parent_id:7731

***level:4

type:child

term:Breast milk

definition:Portion of secreted substance produced by the mammary gland.

parent_id:7731

***level:4

type:child

term:Sweat

definition:Secretion produced by a sweat gland.

parent_id:7731

***level:4

type:child

term:Cerebrospinal fluid

definition:The fluid that is contained within the brain ventricles, the subarachnoid space and the central canal of the spinal cord. (nci).

parent_id:7731

***level:4

type:child

synonym:Csf

term:Subcellular

definition:An anatomical organizational level including a component within a biological cell .

parent_id:7725

**level:3

type:parent

term:Cytoplasm

definition:The portion of the cell contained within the plasma membrane but excluding the nucleus.

parent_id:7730

***level:4

type:child

synonym:Cytoplasma

term:Mitochondria

definition:

parent_id:7730

***level:4

type:child

term:Cell and elements

definition:An anatomical organizational level comprising of a single cell (or a fragment in some exceptions). a cell is defined by its type or function. it is the smallest unit of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid.

parent_id:7725

**level:3

type:parent

term:Extracellular

definition:The space external to the outermost structure of a cell.

parent_id:7732

***level:4

type:child

synonym:Extracellular region

term:Process

definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.

parent_id:

level:1

type:parent

term:Naturally occurring process

definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.

parent_id:7659

*level:2

type:parent

term:Biological process

definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.

parent_id:7660

**level:3

type:parent

term:Biochemical pathway

definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.

parent_id:7661

***level:4

type:parent

term:Role

definition:The purpose or function assumed by a chemical, either naturally or as intended by humans .

parent_id:

level:1

type:parent

term:Industrial application

definition:The assumed function of a chemical utilized by human.

parent_id:7671

*level:2

type:parent

term:Pharmaceutical industry

definition:A pharmacologic activity for which a chemical substance is utilized owing to its biological role.

parent_id:7678

**level:3

type:parent

term:Pharmaceutical

definition:

parent_id:7679

***level:4

type:child

term:Biological role

definition:The biological function of a chemical. the biological role answers the question how a chemical is involved in molecular processes in an organism. this can include biochemical effects of non-endogenous chemicals, which are also assigned an industrial application such as pharmaceuticals. the biological role is limited to cellular levls, and will not include role at system process level, such as a chemical which has a role in a disease.

parent_id:7671

*level:2

type:parent

term:Essential amino acid

definition:

parent_id:7672

**level:3

type:child

状态
Solid
实验性质
1:

kind:water_solubility

value:5.39 mg/mL

source:YALKOWSKY,SH & DANNENFELSER,RM (1992)

2:

kind:logp

value:-3.89

source:CHMELIK,J ET AL. (1991)

3:

kind:melting_point

value:270 °C

source:

预测性质
1:

kind:logp

value:-3.52

source:ALOGPS

2:

kind:logs

value:0.03

source:ALOGPS

3:

kind:solubility

value:142 g/L

source:ALOGPS

4:

kind:logp

value:-3.5

source:ChemAxon

5:

kind:pka_strongest_acidic

value:1.7

source:ChemAxon

6:

kind:pka_strongest_basic

value:9.61

source:ChemAxon

7:

kind:iupac

value:(2S)-2-aminobutanedioic acid

source:ChemAxon

8:

kind:average_mass

value:133.1027

source:ChemAxon

9:

kind:mono_mass

value:133.037507717

source:ChemAxon

10:

kind:smiles

value:N[C@@H](CC(O)=O)C(O)=O

source:ChemAxon

11:

kind:formula

value:C4H7NO4

source:ChemAxon

12:

kind:inchi

value:InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1

source:ChemAxon

13:

kind:inchikey

value:CKLJMWTZIZZHCS-REOHCLBHSA-N

source:ChemAxon

14:

kind:polar_surface_area

value:100.62

source:ChemAxon

15:

kind:refractivity

value:26.53

source:ChemAxon

16:

kind:polarizability

value:11.28

source:ChemAxon

17:

kind:rotatable_bond_count

value:3

source:ChemAxon

18:

kind:acceptor_count

value:5

source:ChemAxon

19:

kind:donor_count

value:3

source:ChemAxon

20:

kind:physiological_charge

value:-1

source:ChemAxon

21:

kind:formal_charge

value:0

source:ChemAxon

22:

kind:number_of_rings

value:0

source:ChemAxon

23:

kind:bioavailability

value:Yes

source:ChemAxon

24:

kind:rule_of_five

value:Yes

source:ChemAxon

25:

kind:ghose_filter

value:No

source:ChemAxon

26:

kind:veber_rule

value:No

source:ChemAxon

27:

kind:mddr_like_rule

value:No

source:ChemAxon

1:

type:Specdb::NmrTwoD

spectrum_id:990

2:

type:Specdb::NmrTwoD

spectrum_id:1196

3:

type:Specdb::CMs

spectrum_id:435

4:

type:Specdb::CMs

spectrum_id:436

5:

type:Specdb::CMs

spectrum_id:437

6:

type:Specdb::CMs

spectrum_id:438

7:

type:Specdb::CMs

spectrum_id:439

8:

type:Specdb::CMs

spectrum_id:440

9:

type:Specdb::CMs

spectrum_id:1130

10:

type:Specdb::CMs

spectrum_id:1205

11:

type:Specdb::CMs

spectrum_id:1395

12:

type:Specdb::CMs

spectrum_id:2688

13:

type:Specdb::CMs

spectrum_id:30054

14:

type:Specdb::CMs

spectrum_id:30200

15:

type:Specdb::CMs

spectrum_id:30303

16:

type:Specdb::CMs

spectrum_id:30304

17:

type:Specdb::CMs

spectrum_id:30305

18:

type:Specdb::CMs

spectrum_id:30484

19:

type:Specdb::CMs

spectrum_id:30733

20:

type:Specdb::CMs

spectrum_id:30883

21:

type:Specdb::CMs

spectrum_id:31058

22:

type:Specdb::CMs

spectrum_id:31059

23:

type:Specdb::CMs

spectrum_id:31060

24:

type:Specdb::CMs

spectrum_id:37347

25:

type:Specdb::CMs

spectrum_id:173357

26:

type:Specdb::NmrOneD

spectrum_id:1164

27:

type:Specdb::NmrOneD

spectrum_id:1199

28:

type:Specdb::NmrOneD

spectrum_id:4995

29:

type:Specdb::NmrOneD

spectrum_id:6092

30:

type:Specdb::NmrOneD

spectrum_id:6093

31:

type:Specdb::NmrOneD

spectrum_id:6094

32:

type:Specdb::NmrOneD

spectrum_id:6095

33:

type:Specdb::NmrOneD

spectrum_id:6096

34:

type:Specdb::NmrOneD

spectrum_id:6097

35:

type:Specdb::NmrOneD

spectrum_id:6098

36:

type:Specdb::NmrOneD

spectrum_id:6099

37:

type:Specdb::NmrOneD

spectrum_id:6100

38:

type:Specdb::NmrOneD

spectrum_id:6101

39:

type:Specdb::NmrOneD

spectrum_id:6102

40:

type:Specdb::NmrOneD

spectrum_id:6103

41:

type:Specdb::NmrOneD

spectrum_id:6104

42:

type:Specdb::NmrOneD

spectrum_id:6105

43:

type:Specdb::NmrOneD

spectrum_id:6106

44:

type:Specdb::NmrOneD

spectrum_id:6107

45:

type:Specdb::NmrOneD

spectrum_id:6108

46:

type:Specdb::NmrOneD

spectrum_id:6109

47:

type:Specdb::NmrOneD

spectrum_id:6110

48:

type:Specdb::NmrOneD

spectrum_id:6111

49:

type:Specdb::NmrOneD

spectrum_id:166470

50:

type:Specdb::MsMs

spectrum_id:304

51:

type:Specdb::MsMs

spectrum_id:305

52:

type:Specdb::MsMs

spectrum_id:306

53:

type:Specdb::MsMs

spectrum_id:3473

54:

type:Specdb::MsMs

spectrum_id:3474

55:

type:Specdb::MsMs

spectrum_id:3475

56:

type:Specdb::MsMs

spectrum_id:3476

57:

type:Specdb::MsMs

spectrum_id:3477

58:

type:Specdb::MsMs

spectrum_id:3478

59:

type:Specdb::MsMs

spectrum_id:3479

60:

type:Specdb::MsMs

spectrum_id:3480

61:

type:Specdb::MsMs

spectrum_id:3481

62:

type:Specdb::MsMs

spectrum_id:3482

63:

type:Specdb::MsMs

spectrum_id:3483

64:

type:Specdb::MsMs

spectrum_id:3484

65:

type:Specdb::MsMs

spectrum_id:3485

66:

type:Specdb::MsMs

spectrum_id:3486

67:

type:Specdb::MsMs

spectrum_id:3487

68:

type:Specdb::MsMs

spectrum_id:3488

69:

type:Specdb::MsMs

spectrum_id:3489

70:

type:Specdb::MsMs

spectrum_id:3490

71:

type:Specdb::MsMs

spectrum_id:3491

72:

type:Specdb::MsMs

spectrum_id:3492

73:

type:Specdb::MsMs

spectrum_id:3493

74:

type:Specdb::MsMs

spectrum_id:3494

光谱
生物学性质
1:

cellular:(1):Cytoplasm

cellular:(2):Extracellular

cellular:(3):Mitochondria

2:

biospecimen:(1):Blood

biospecimen:(2):Breast Milk

biospecimen:(3):Cerebrospinal Fluid (CSF)

biospecimen:(4):Feces

biospecimen:(5):Saliva

biospecimen:(6):Sweat

biospecimen:(7):Urine

3:

tissue:(1):All Tissues

tissue:(2):Placenta

tissue:(3):Prostate

4:

[1]:

name:2-Hydroxyglutric Aciduria (D And L Form)

smpdb_id:SMP00136

kegg_map_id:

[2]:

name:4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency

smpdb_id:SMP00243

kegg_map_id:

[3]:

name:Adenine phosphoribosyltransferase deficiency (APRT)

smpdb_id:SMP00535

kegg_map_id:

[4]:

name:Adenosine Deaminase Deficiency

smpdb_id:SMP00144

kegg_map_id:

[5]:

name:Adenylosuccinate Lyase Deficiency

smpdb_id:SMP00167

kegg_map_id:

[6]:

name:AICA-Ribosiduria

smpdb_id:SMP00168

kegg_map_id:

[7]:

name:Alkaptonuria

smpdb_id:SMP00169

kegg_map_id:

[8]:

name:Arginine and proline metabolism

smpdb_id:

kegg_map_id:map00330

[9]:

name:Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency)

smpdb_id:SMP00362

kegg_map_id:

[10]:

name:Argininemia

smpdb_id:SMP00357

kegg_map_id:

[11]:

name:Argininosuccinic Aciduria

smpdb_id:SMP00003

kegg_map_id:

[12]:

name:Aspartate Metabolism

smpdb_id:SMP00067

kegg_map_id:map00250

[13]:

name:Azathioprine Action Pathway

smpdb_id:SMP00427

kegg_map_id:

[14]:

name:beta-Alanine metabolism

smpdb_id:

kegg_map_id:map00410

[15]:

name:Canavan Disease

smpdb_id:SMP00175

kegg_map_id:

[16]:

name:Carbamoyl Phosphate Synthetase Deficiency

smpdb_id:SMP00002

kegg_map_id:

[17]:

name:Carnosinuria, carnosinemia

smpdb_id:SMP00493

kegg_map_id:

[18]:

name:Citrullinemia Type I

smpdb_id:SMP00001

kegg_map_id:

[19]:

name:Creatine deficiency, guanidinoacetate methyltransferase deficiency

smpdb_id:SMP00504

kegg_map_id:

[20]:

name:Disulfiram Action Pathway

smpdb_id:SMP00429

kegg_map_id:

[21]:

name:Dopamine beta-hydroxylase deficiency

smpdb_id:SMP00498

kegg_map_id:

[22]:

name:GABA-Transaminase Deficiency

smpdb_id:SMP00351

kegg_map_id:

[23]:

name:Glutamate Metabolism

smpdb_id:SMP00072

kegg_map_id:map00250

[24]:

name:Glutaminolysis and Cancer

smpdb_id:SMP02298

kegg_map_id:

[25]:

name:Gout or Kelley-Seegmiller Syndrome

smpdb_id:SMP00365

kegg_map_id:

[26]:

name:Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency)

smpdb_id:SMP00188

kegg_map_id:

[27]:

name:Hawkinsinuria

smpdb_id:SMP00190

kegg_map_id:

[28]:

name:Homocarnosinosis

smpdb_id:SMP00385

kegg_map_id:

[29]:

name:Hyperinsulinism-Hyperammonemia Syndrome

smpdb_id:SMP00339

kegg_map_id:

[30]:

name:Hyperornithinemia with gyrate atrophy (HOGA)

smpdb_id:SMP00505

kegg_map_id:

[31]:

name:Hyperornithinemia-hyperammonemia-homocitrullinuria [HHH-syndrome]

smpdb_id:SMP00506

kegg_map_id:

[32]:

name:Hyperprolinemia Type I

smpdb_id:SMP00361

kegg_map_id:

[33]:

name:Hyperprolinemia Type II

smpdb_id:SMP00360

kegg_map_id:

[34]:

name:Hypoacetylaspartia

smpdb_id:SMP00192

kegg_map_id:

[35]:

name:L-arginine:glycine amidinotransferase deficiency

smpdb_id:SMP00507

kegg_map_id:

[36]:

name:Lesch-Nyhan Syndrome (LNS)

smpdb_id:SMP00364

kegg_map_id:

[37]:

name:Malate-Aspartate Shuttle

smpdb_id:SMP00129

kegg_map_id:

[38]:

name:Mercaptopurine Action Pathway

smpdb_id:SMP00428

kegg_map_id:

[39]:

name:Mitochondrial DNA depletion syndrome

smpdb_id:SMP00536

kegg_map_id:

[40]:

name:Molybdenum Cofactor Deficiency

smpdb_id:SMP00203

kegg_map_id:

[41]:

name:Monoamine oxidase-a deficiency (MAO-A)

smpdb_id:SMP00533

kegg_map_id:

[42]:

name:Myoadenylate deaminase deficiency

smpdb_id:SMP00537

kegg_map_id:

[43]:

name:Nitrogen metabolism

smpdb_id:

kegg_map_id:map00910

[44]:

name:Ornithine Aminotransferase Deficiency (OAT Deficiency)

smpdb_id:SMP00363

kegg_map_id:

[45]:

name:Ornithine Transcarbamylase Deficiency (OTC Deficiency)

smpdb_id:SMP00205

kegg_map_id:

[46]:

name:Prolidase Deficiency (PD)

smpdb_id:SMP00207

kegg_map_id:

[47]:

name:Prolinemia Type II

smpdb_id:SMP00208

kegg_map_id:

[48]:

name:Purine metabolism

smpdb_id:

kegg_map_id:map00230

[49]:

name:Purine Nucleoside Phosphorylase Deficiency

smpdb_id:SMP00210

kegg_map_id:

[50]:

name:Succinic semialdehyde dehydrogenase deficiency

smpdb_id:SMP00567

kegg_map_id:

[51]:

name:Thioguanine Action Pathway

smpdb_id:SMP00430

kegg_map_id:

[52]:

name:Transcription/Translation

smpdb_id:SMP00019

kegg_map_id:

[53]:

name:Tyrosine metabolism

smpdb_id:

kegg_map_id:map00350

[54]:

name:Tyrosinemia Type I

smpdb_id:SMP00218

kegg_map_id:

[55]:

name:Tyrosinemia, transient, of the newborn

smpdb_id:SMP00494

kegg_map_id:

[56]:

name:Urea Cycle

smpdb_id:SMP00059

kegg_map_id:map00330

[57]:

name:Ureidopropionase Deficiency

smpdb_id:SMP00492

kegg_map_id:

[58]:

name:Xanthine Dehydrogenase Deficiency (Xanthinuria)

smpdb_id:SMP00220

kegg_map_id:

[59]:

name:Xanthinuria type I

smpdb_id:SMP00512

kegg_map_id:

[60]:

name:Xanthinuria type II

smpdb_id:SMP00513

kegg_map_id:

正常浓度
1:

biospecimen:Blood

concentration_value:21.0 +/- 5.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

2:

biospecimen:Blood

concentration_value:20.0 +/- 5.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

3:

biospecimen:Blood

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

4:

biospecimen:Blood

concentration_value:15.5 (tr-32.1)

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

5:

biospecimen:Blood

concentration_value:6.26 +/- 2.34

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

6:

biospecimen:Blood

concentration_value:8.00-20.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

7:

biospecimen:Blood

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

8:

biospecimen:Blood

concentration_value:54.4(47.3-68.3)

concentration_units:uM

subject_age:Children (1-13 uears old)

subject_sex:Both

subject_condition:Normal

9:

biospecimen:Blood

concentration_value:20.9 +/- 6.1

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

10:

biospecimen:Blood

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

11:

biospecimen:Breast Milk

concentration_value:52.9 +/- 33.6

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

12:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:2.30 (0.0-4.6)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

13:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:2.8 +/- 1.2

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

14:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:1.8 +/- 0.2

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

15:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.6 +/- 0.3

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

16:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.6 +/- 0.3

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

17:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.9 +/- 0.5

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

18:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:2.19 +/- 2.63

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

19:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.23 +/- 0.18

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

20:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

21:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

22:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

23:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

24:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

25:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

26:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

27:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

28:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Children (6 - 18 years old)

subject_sex:Both

subject_condition:Normal

29:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Children (6 - 18 years old)

subject_sex:Not Specified

subject_condition:Normal

30:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

31:

biospecimen:Feces

concentration_value:90 +/- 90

concentration_units:nmol/g wet feces

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

32:

biospecimen:Feces

concentration_value:130 +/- 120

concentration_units:nmol/g wet feces

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

33:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

34:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

35:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

36:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

37:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

38:

biospecimen:Saliva

concentration_value:6.54 +/- 2.35

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

39:

biospecimen:Saliva

concentration_value:18.2 +/- 14.6

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

40:

biospecimen:Saliva

concentration_value:2.6 +/- 3.6

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

41:

biospecimen:Saliva

concentration_value:1.5 +/- 2.1

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

42:

biospecimen:Saliva

concentration_value:<0.25

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

43:

biospecimen:Saliva

concentration_value:>10

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

44:

biospecimen:Saliva

concentration_value:33.30 +/- 19.39

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

45:

biospecimen:Saliva

concentration_value:<0.25

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

46:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

47:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

48:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

49:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

50:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

51:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

52:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

53:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

54:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

55:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

56:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

57:

biospecimen:Saliva

concentration_value:13.83 +/- 5.06

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

58:

biospecimen:Sweat

concentration_value:< 10

concentration_units:uM

subject_age:Adult (60 years old)

subject_sex:Male

subject_condition:Normal

59:

biospecimen:Sweat

concentration_value:< 10

concentration_units:uM

subject_age:Adult (40 years old)

subject_sex:Male

subject_condition:Normal

60:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

61:

biospecimen:Urine

concentration_value:5.57-34.61

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

62:

biospecimen:Urine

concentration_value:16.85 +/- 7.16

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Female

subject_condition:Normal

63:

biospecimen:Urine

concentration_value:16.88 +/- 7.25

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Male

subject_condition:Normal

64:

biospecimen:Urine

concentration_value:0.43-0.82

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

65:

biospecimen:Urine

concentration_value:1.36 +/- 1.06

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

66:

biospecimen:Urine

concentration_value:25.11 (20-30.22)

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

67:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

68:

biospecimen:Urine

concentration_value:10.9 (3.5-21.8)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

69:

biospecimen:Urine

concentration_value:16.115 +/- 7.486

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

70:

biospecimen:Urine

concentration_value:5.2 +/- 6.15

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

71:

biospecimen:Urine

concentration_value:0.4 +/- 0.2

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

72:

biospecimen:Urine

concentration_value:0.44-0.68

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

73:

biospecimen:Urine

concentration_value:0.5 +/-0.4

concentration_units:umol/mmol creatinine

subject_age:Infant (1 - 6 months old)

subject_sex:Both

subject_condition:Normal

74:

biospecimen:Urine

concentration_value:0.6 +/- 0.3

concentration_units:umol/mmol creatinine

subject_age:Infant (6 months - <1 year old)

subject_sex:Both

subject_condition:Normal

75:

biospecimen:Urine

concentration_value:10.9 (1.9-26.8)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

76:

biospecimen:Urine

concentration_value:0.5

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

77:

biospecimen:Urine

concentration_value:51.1451 +/- 42.3486

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

78:

biospecimen:Urine

concentration_value:4.638 (1.711-7.566)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

79:

biospecimen:Urine

concentration_value:16.62 +/- 12.44

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

80:

biospecimen:Urine

concentration_value:18.20 +/- 13.57

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

81:

biospecimen:Urine

concentration_value:18.20 +/- 18.09

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

异常浓度
1:

biospecimen:Blood

concentration_value:36.0 +/- 9.0

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Cirrhosis

2:

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

3:

biospecimen:Blood

concentration_value:3.9 (3.7-4.1)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Epilepsy

4:

biospecimen:Blood

concentration_value:11.8 (10.9-12.7)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Epilepsy

5:

biospecimen:Blood

concentration_value:2.6 (tr-5.0)

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Male

patient_information:Dicarboxylic Aminoaciduria

6:

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

7:

biospecimen:Blood

concentration_value:56.7(42.3-70.3)

concentration_units:uM

patient_age:Children (1-13 uears old)

patient_sex:Both

patient_information:Environmental enteric dysfunction

8:

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Schizophrenia

9:

biospecimen:Blood

concentration_value:12.67 +/- 2.86

concentration_units:uM

patient_age:Elderly (>65 years old)

patient_sex:Both

patient_information:Alzheimer's disease

10:

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Schizophrenia

11:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.233 +/- 0.081

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Not Specified

patient_information:Growth hormone deficiency

12:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:trace

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Male

patient_information:Dicarboxylic Aminoaciduria

13:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.24 +/- 0.10

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Schizophrenia

14:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Gout

15:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal Cancer

16:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Irritable bowel syndrome

17:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Ulcerative colitis

18:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Immunoglobulin A nephropathy (IgAN) progressor

19:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

20:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Not Specified

patient_sex:Not Specified

patient_information:Cryptosporidium infection

21:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

22:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Both

patient_information:Crohns disease

23:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Both

patient_information:Ulcerative colitis

24:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Crohns disease

25:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Ulcerative colitis

26:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

27:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Unclassified IBD

28:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Crohns disease

29:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Ulcerative colitis

30:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

31:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

32:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Attachment loss 

33:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Missing teeth

34:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Periodontal Probing Depth

35:

biospecimen:Saliva

concentration_value:9.62 +/- 6.59

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Alzheimer's disease

36:

biospecimen:Saliva

concentration_value:11.32 +/- 3.39

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Frontotemporal lobe dementia

37:

biospecimen:Saliva

concentration_value:13.36 +/- 3.74

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Lewy body disease

38:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Oral cancer

39:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Breast cancer

40:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Not Specified

patient_information:Pancreatic cancer

41:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Not Specified

patient_information:Periodontal diseases

42:

biospecimen:Urine

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Bladder cancer

43:

biospecimen:Urine

concentration_value:24.087 +/- 22.064

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Eosinophilic esophagitis

44:

biospecimen:Urine

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

45:

biospecimen:Urine

concentration_value:29.311 +/- 17.1956

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Eosinophilic esophagitis

46:

biospecimen:Urine

concentration_value:28.1856 +/- 25.7291

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Gastroesophageal reflux disease

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6:

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reference_text:Grace PB, Mistry NS, Carter MH, Leathem AJ, Teale P: High throughput quantification of phytoestrogens in human urine and serum using liquid chromatography/tandem mass spectrometry (LC-MS/MS). J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 15;853(1-2):138-46. Epub 2007 Mar 18.

pubmed_id:17403619

[6]:

reference_text:Silva CL, Passos M, Camara JS: Solid phase microextraction, mass spectrometry and metabolomic approaches for detection of potential urinary cancer biomarkers--a powerful strategy for breast cancer diagnosis. Talanta. 2012 Jan 30;89:360-8. doi: 10.1016/j.talanta.2011.12.041. Epub 2011 Dec 22.

pubmed_id:22284503

[7]:

reference_text:Sugimoto M, Wong DT, Hirayama A, Soga T, Tomita M: Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles. Metabolomics. 2010 Mar;6(1):78-95. Epub 2009 Sep 10.

pubmed_id:20300169

[8]:

reference_text:Lv W, Yang T: Identification of possible biomarkers for breast cancer from free fatty acid profiles determined by GC-MS and multivariate statistical analysis. Clin Biochem. 2012 Jan;45(1-2):127-33. doi: 10.1016/j.clinbiochem.2011.10.011. Epub 2011 Oct 26.

pubmed_id:22061338

[9]:

reference_text:Nam H, Chung BC, Kim Y, Lee K, Lee D: Combining tissue transcriptomics and urine metabolomics for breast cancer biomarker identification. Bioinformatics. 2009 Dec 1;25(23):3151-7. doi: 10.1093/bioinformatics/btp558. Epub 2009 Sep 25.

pubmed_id:19783829

[10]:

reference_text:Woo HM, Kim KM, Choi MH, Jung BH, Lee J, Kong G, Nam SJ, Kim S, Bai SW, Chung BC: Mass spectrometry based metabolomic approaches in urinary biomarker study of women's cancers. Clin Chim Acta. 2009 Feb;400(1-2):63-9. doi: 10.1016/j.cca.2008.10.014. Epub 2008 Oct 30.

pubmed_id:19010317

13:

name:Pancreatic cancer

omim_id:260350

[1]:

reference_text:Loser C, Folsch UR, Paprotny C, Creutzfeldt W: Polyamine concentrations in pancreatic tissue, serum, and urine of patients with pancreatic cancer. Pancreas. 1990 Mar;5(2):119-27.

pubmed_id:2315288

[2]:

reference_text:Sugimoto M, Wong DT, Hirayama A, Soga T, Tomita M: Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles. Metabolomics. 2010 Mar;6(1):78-95. Epub 2009 Sep 10.

pubmed_id:20300169

[3]:

reference_text:Zhang L, Jin H, Guo X, Yang Z, Zhao L, Tang S, Mo P, Wu K, Nie Y, Pan Y, Fan D: Distinguishing pancreatic cancer from chronic pancreatitis and healthy individuals by (1)H nuclear magnetic resonance-based metabonomic profiles. Clin Biochem. 2012 Sep;45(13-14):1064-9. doi: 10.1016/j.clinbiochem.2012.05.012. Epub 2012 May 19.

pubmed_id:22613268

[4]:

reference_text:OuYang D, Xu J, Huang H, Chen Z: Metabolomic profiling of serum from human pancreatic cancer patients using 1H NMR spectroscopy and principal component analysis. Appl Biochem Biotechnol. 2011 Sep;165(1):148-54. doi: 10.1007/s12010-011-9240-0. Epub 2011 Apr 20.

pubmed_id:21505807

[5]:

reference_text:Xie G, Lu L, Qiu Y, Ni Q, Zhang W, Gao YT, Risch HA, Yu H, Jia W: Plasma metabolite biomarkers for the detection of pancreatic cancer. J Proteome Res. 2015 Feb 6;14(2):1195-202. doi: 10.1021/pr501135f. Epub 2014 Dec 8.

pubmed_id:25429707

14:

name:Periodontal disease

omim_id:170650

[1]:

reference_text:Sugimoto M, Wong DT, Hirayama A, Soga T, Tomita M: Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles. Metabolomics. 2010 Mar;6(1):78-95. Epub 2009 Sep 10.

pubmed_id:20300169

15:

name:Frontotemporal dementia

omim_id:600274

[1]:

reference_text:Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6.

pubmed_id:23857558

16:

name:Lewy body disease

omim_id:

[1]:

reference_text:Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6.

pubmed_id:23857558

17:

name:Attachment loss

omim_id:

[1]:

reference_text:Liebsch C, Pitchika V, Pink C, Samietz S, Kastenmuller G, Artati A, Suhre K, Adamski J, Nauck M, Volzke H, Friedrich N, Kocher T, Holtfreter B, Pietzner M: The Saliva Metabolome in Association to Oral Health Status. J Dent Res. 2019 Jun;98(6):642-651. doi: 10.1177/0022034519842853. Epub 2019 Apr 26.

pubmed_id:31026179

18:

name:Missing teeth

omim_id:

[1]:

reference_text:Liebsch C, Pitchika V, Pink C, Samietz S, Kastenmuller G, Artati A, Suhre K, Adamski J, Nauck M, Volzke H, Friedrich N, Kocher T, Holtfreter B, Pietzner M: The Saliva Metabolome in Association to Oral Health Status. J Dent Res. 2019 Jun;98(6):642-651. doi: 10.1177/0022034519842853. Epub 2019 Apr 26.

pubmed_id:31026179

19:

name:Periodontal Probing Depth

omim_id:

[1]:

reference_text:Liebsch C, Pitchika V, Pink C, Samietz S, Kastenmuller G, Artati A, Suhre K, Adamski J, Nauck M, Volzke H, Friedrich N, Kocher T, Holtfreter B, Pietzner M: The Saliva Metabolome in Association to Oral Health Status. J Dent Res. 2019 Jun;98(6):642-651. doi: 10.1177/0022034519842853. Epub 2019 Apr 26.

pubmed_id:31026179

20:

name:Eosinophilic esophagitis

omim_id:610247

[1]:

reference_text:Mordechai, Hien, and David S. Wishart

pubmed_id:

KEGG数据库编号
C00049
DrugBank数据库编号
DB00128
foodb数据库编号
FDB012567
ChemSpider数据库编号
5745
公共化学化合物编号
5960
PDB数据库编号
生物利益的化学实体数据库编号
17053
knapsack数据库编号
C00001342
维基百科编号
Aspartic acid
代谢途径的数据库编号
L-ASPARTATE
苯酚资源管理器化合物数据库编号
比格数据库编号
33663
梅林编号
5206
虚拟机身份证编号
ASP_L
fbonto数据库编号
综合参考
Pamfil, Maria; Lupescu, Irina; Savoiu, Valeria Gabriela. L-aspartic acid production from fumarate using Escherichia coli whole cells. Rom. (2005), 3pp.
一般参考
1:

protein_accession:HMDBP00283

name:Aspartate aminotransferase, cytoplasmic

uniprot_id:P17174

gene_name:GOT1

protein_type:Enzyme

2:

protein_accession:HMDBP00284

name:Aspartate aminotransferase, mitochondrial

uniprot_id:P00505

gene_name:GOT2

protein_type:Enzyme

3:

protein_accession:HMDBP00457

name:Ribonuclease pancreatic

uniprot_id:P07998

gene_name:RNASE1

protein_type:Enzyme

4:

protein_accession:HMDBP00554

name:Aminoacylase-1

uniprot_id:Q03154

gene_name:ACY1

protein_type:Unknown

5:

protein_accession:HMDBP00555

name:Aspartoacylase

uniprot_id:P45381

gene_name:ASPA

protein_type:Enzyme

6:

protein_accession:HMDBP00558

name:Aspartoacylase-2

uniprot_id:Q96HD9

gene_name:ACY3

protein_type:Enzyme

7:

protein_accession:HMDBP00583

name:Asparagine synthetase [glutamine-hydrolyzing]

uniprot_id:P08243

gene_name:ASNS

protein_type:Enzyme

8:

protein_accession:HMDBP00608

name:Aspartate--tRNA ligase, cytoplasmic

uniprot_id:P14868

gene_name:DARS

protein_type:Enzyme

9:

protein_accession:HMDBP00656

name:Argininosuccinate synthase

uniprot_id:P00966

gene_name:ASS1

protein_type:Enzyme

10:

protein_accession:HMDBP00694

name:Glutamate dehydrogenase 1, mitochondrial

uniprot_id:P00367

gene_name:GLUD1

protein_type:Unknown

11:

protein_accession:HMDBP00702

name:Glutamate decarboxylase 2

uniprot_id:Q05329

gene_name:GAD2

protein_type:Enzyme

12:

protein_accession:HMDBP00703

name:Glutamate decarboxylase 1

uniprot_id:Q99259

gene_name:GAD1

protein_type:Enzyme

13:

protein_accession:HMDBP00880

name:Adenylosuccinate synthetase isozyme 2

uniprot_id:P30520

gene_name:ADSS

protein_type:Unknown

14:

protein_accession:HMDBP00884

name:Adenylosuccinate synthetase isozyme 1

uniprot_id:Q8N142

gene_name:ADSSL1

protein_type:Unknown

15:

protein_accession:HMDBP00894

name:Multifunctional protein ADE2

uniprot_id:P22234

gene_name:PAICS

protein_type:Enzyme

16:

protein_accession:HMDBP00895

name:N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase

uniprot_id:P20933

gene_name:AGA

protein_type:Enzyme

17:

protein_accession:HMDBP01022

name:Aspartyl/asparaginyl beta-hydroxylase

uniprot_id:Q12797

gene_name:ASPH

protein_type:Unknown

18:

protein_accession:HMDBP01600

name:Lysozyme C

uniprot_id:P61626

gene_name:LYZ

protein_type:Enzyme

19:

protein_accession:HMDBP02333

name:Calcium-binding mitochondrial carrier protein Aralar2

uniprot_id:Q9UJS0

gene_name:SLC25A13

protein_type:Unknown

20:

protein_accession:HMDBP03094

name:Excitatory amino acid transporter 3

uniprot_id:P43005

gene_name:SLC1A1

protein_type:Unknown

21:

protein_accession:HMDBP03143

name:Calcium-binding mitochondrial carrier protein Aralar1

uniprot_id:O75746

gene_name:SLC25A12

protein_type:Unknown

22:

protein_accession:HMDBP03298

name:CAD protein

uniprot_id:P27708

gene_name:CAD

protein_type:Unknown

23:

protein_accession:HMDBP03342

name:Isoaspartyl peptidase/L-asparaginase

uniprot_id:Q7L266

gene_name:ASRGL1

protein_type:Enzyme

24:

protein_accession:HMDBP05340

name:Monocarboxylate transporter 10

uniprot_id:Q8TF71

gene_name:SLC16A10

protein_type:Transporter

25:

protein_accession:HMDBP07300

name:60 kDa lysophospholipase

uniprot_id:Q86U10

gene_name:ASPG

protein_type:Enzyme

26:

protein_accession:HMDBP08281

name:L-amino-acid oxidase

uniprot_id:Q96RQ9

gene_name:IL4I1

protein_type:Unknown

27:

protein_accession:HMDBP08860

name:Putative L-aspartate dehydrogenase

uniprot_id:A6ND91

gene_name:ASPDH

protein_type:Unknown

28:

protein_accession:HMDBP08965

name:Putative aspartate aminotransferase, cytoplasmic 2

uniprot_id:Q8NHS2

gene_name:GOT1L1

protein_type:Enzyme

29:

protein_accession:HMDBP08982

name:Aspartate aminotransferase

uniprot_id:Q2TU84

gene_name:GIG18

protein_type:Enzyme

30:

protein_accession:HMDBP09114

name:Argininosuccinate synthase

uniprot_id:Q5T6L4

gene_name:ASS1

protein_type:Enzyme

31:

protein_accession:HMDBP09252

name:Aspartate--tRNA ligase, mitochondrial

uniprot_id:Q6PI48

gene_name:DARS2

protein_type:Enzyme

32:

protein_accession:HMDBP11849

name:N-acetylaspartate synthetase

uniprot_id:Q8N9F0

gene_name:NAT8L

protein_type:Unknown

蛋白质结合
1:

reference_text:Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762.

pubmed_id:19212411

2:

reference_text:Silwood CJ, Lynch E, Claxson AW, Grootveld MC: 1H and (13)C NMR spectroscopic analysis of human saliva. J Dent Res. 2002 Jun;81(6):422-7.

pubmed_id:12097436

3:

reference_text:Nicholson JK, O'Flynn MP, Sadler PJ, Macleod AF, Juul SM, Sonksen PH: Proton-nuclear-magnetic-resonance studies of serum, plasma and urine from fasting normal and diabetic subjects. Biochem J. 1984 Jan 15;217(2):365-75.

pubmed_id:6696735

4:

reference_text:Engelborghs S, Marescau B, De Deyn PP: Amino acids and biogenic amines in cerebrospinal fluid of patients with Parkinson's disease. Neurochem Res. 2003 Aug;28(8):1145-50.

pubmed_id:12834252

5:

reference_text:Burman P, Hetta J, Wide L, Mansson JE, Ekman R, Karlsson FA: Growth hormone treatment affects brain neurotransmitters and thyroxine [see comment]. Clin Endocrinol (Oxf). 1996 Mar;44(3):319-24.

pubmed_id:8729530

6:

reference_text:Hagenfeldt L, Bjerkenstedt L, Edman G, Sedvall G, Wiesel FA: Amino acids in plasma and CSF and monoamine metabolites in CSF: interrelationship in healthy subjects. J Neurochem. 1984 Mar;42(3):833-7.

pubmed_id:6198473

7:

reference_text:Cynober LA: Plasma amino acid levels with a note on membrane transport: characteristics, regulation, and metabolic significance. Nutrition. 2002 Sep;18(9):761-6.

pubmed_id:12297216

8:

reference_text:Rainesalo S, Keranen T, Palmio J, Peltola J, Oja SS, Saransaari P: Plasma and cerebrospinal fluid amino acids in epileptic patients. Neurochem Res. 2004 Jan;29(1):319-24.

pubmed_id:14992292

9:

reference_text:Chiara F, Goumans MJ, Forsberg H, Ahgren A, Rasola A, Aspenstrom P, Wernstedt C, Hellberg C, Heldin CH, Heuchel R: A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity. J Biol Chem. 2004 Oct 8;279(41):42516-27. Epub 2004 Jul 28.

pubmed_id:15284236

10:

reference_text:Fujii N: D-amino acid in elderly tissues. Biol Pharm Bull. 2005 Sep;28(9):1585-9.

pubmed_id:16141520

11:

reference_text:Grdzelishvili VZ, Smallwood S, Tower D, Hall RL, Hunt DM, Moyer SA: A single amino acid change in the L-polymerase protein of vesicular stomatitis virus completely abolishes viral mRNA cap methylation. J Virol. 2005 Jun;79(12):7327-37.

pubmed_id:15919887

12:

reference_text:Lockridge O: Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine. Pharmacol Ther. 1990;47(1):35-60.

pubmed_id:2195556

13:

reference_text:Franklin RB, Zou J, Yu Z, Costello LC: EAAC1 is expressed in rat and human prostate epithelial cells; functions as a high-affinity L-aspartate transporter; and is regulated by prolactin and testosterone. BMC Biochem. 2006 Mar 27;7:10.

pubmed_id:16566829

14:

reference_text:Advani SJ, Hagglund R, Weichselbaum RR, Roizman B: Posttranslational processing of infected cell proteins 0 and 4 of herpes simplex virus 1 is sequential and reflects the subcellular compartment in which the proteins localize. J Virol. 2001 Sep;75(17):7904-12.

pubmed_id:11483735

15:

reference_text:Wang M, Meng Z, Fu J: Synthesis and biodistribution of six novel 99mTc complexes of 2-hydroxybenzaldehyde-amino acid Schiff bases. Appl Radiat Isot. 2006 Feb;64(2):235-40.

pubmed_id:16309915

16:

reference_text:Fisher G, Lopez S, Peterson K, Goff T, Philip I, Gaviria R, Lorenzo N, Tsesarskaia M: Is there a correlation between age and D: -aspartic acid in human knee cartilage? Amino Acids. 2006 Jun 1;.

pubmed_id:16738792

17:

reference_text:Baslow MH: Brain N-acetylaspartate as a molecular water pump and its role in the etiology of Canavan disease: a mechanistic explanation. J Mol Neurosci. 2003;21(3):185-90.

pubmed_id:14645985

18:

reference_text:Shao B, Belaaouaj A, Verlinde CL, Fu X, Heinecke JW: Methionine sulfoxide and proteolytic cleavage contribute to the inactivation of cathepsin G by hypochlorous acid: an oxidative mechanism for regulation of serine proteinases by myeloperoxidase. J Biol Chem. 2005 Aug 12;280(32):29311-21. Epub 2005 Jun 20.

pubmed_id:15967795

19:

reference_text:Rose CH, Thigpen BD, Bofill JA, Cushman J, May WL, Martin JN Jr: Obstetric implications of antepartum corticosteroid therapy for HELLP syndrome. Obstet Gynecol. 2004 Nov;104(5 Pt 1):1011-4.

pubmed_id:15516393

20:

reference_text:Bhende PM, Seaman WT, Delecluse HJ, Kenney SC: BZLF1 activation of the methylated form of the BRLF1 immediate-early promoter is regulated by BZLF1 residue 186. J Virol. 2005 Jun;79(12):7338-48.

pubmed_id:15919888

21:

reference_text:Butterworth RF: Pathophysiology of hepatic encephalopathy: a new look at ammonia. Metab Brain Dis. 2002 Dec;17(4):221-7.

pubmed_id:12602499

22:

reference_text:Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043.

pubmed_id:32033212

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