人类代谢组数据库

版本

5.0

创建日期

2005-11-16 15:48:42 UTC

更新日期

2021-09-14 15:20:01 UTC

登录号

HMDB0000187

地位

quantified

二级访问

HMDB0000589

HMDB00187

HMDB00589

HMDB0062263

HMDB62263

名称

L-Serine

描述

Serine (Ser) or L-serine is an alpha-amino acid. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). Amino acids are organic compounds that contain amino (‚ÄìNH2) and carboxyl (‚ÄìCOOH) functional groups, along with a side chain (R group) specific to each amino acid. L-serine is one of 20 proteinogenic amino acids, i.e., the amino acids used in the biosynthesis of proteins. Serine is found in all organisms ranging from bacteria to plants to animals. It is classified as a polar, uncharged (at physiological pH), aliphatic amino acid. In humans, serine is a nonessential amino acid that can be easily derived from glycine. A non-essential amino acid is an amino acid that can be synthesized from central metabolic pathway intermediates in humans and is not required in the diet. Like all the amino acid building blocks of protein and peptides, serine can become essential under certain conditions, and is thus important in maintaining health and preventing disease. L-Serine may be derived from four possible sources: dietary intake; biosynthesis from the glycolytic intermediate 3-phosphoglycerate; from glycine; and by protein and phospholipid degradation. Little data is available on the relative contributions of each of these four sources of l-serine to serine homoeostasis. It is very likely that the predominant source of l-serine will be very different in different tissues and during different stages of human development. In the biosynthetic pathway, the glycolytic intermediate 3-phosphoglycerate is converted into phosphohydroxypyruvate, in a reaction catalyzed by 3-phosphoglycerate dehydrogenase (3- PGDH; EC 1.1.1.95). Phosphohydroxypyruvate is metabolized to phosphoserine by phosphohydroxypyruvate aminotransferase (EC 2.6.1.52) and, finally, phosphoserine is converted into l-serine by phosphoserine phosphatase (PSP; EC 3.1.3.3). In liver tissue, the serine biosynthetic pathway is regulated in response to dietary and hormonal changes. Of the three synthetic enzymes, the properties of 3-PGDH and PSP are the best documented. Hormonal factors such as glucagon and corticosteroids also influence 3-PGDH and PSP activities in interactions dependent upon the diet. L-serine is the predominant source of one-carbon groups for the de novo synthesis of purine nucleotides and deoxythymidine monophosphate. It has long been recognized that, in cell cultures, L-serine is a conditional essential amino acid, because it cannot be synthesized in sufficient quantities to meet the cellular demands for its utilization. In recent years, L-serine and the products of its metabolism have been recognized not only to be essential for cell proliferation, but also to be necessary for specific functions in the central nervous system. The findings of altered levels of serine and glycine in patients with psychiatric disorders and the severe neurological abnormalities in patients with defects of L-serine synthesis underscore the importance of L-serine in brain development and function. (PMID 12534373).

同义词

1:(2S)-2-Amino-3-hydroxypropanoic acid

2:(S)-(-)-Serine

3:(S)-2-Amino-3-hydroxypropanoic acid

4:(S)-alpha-Amino-beta-hydroxypropionic acid

5:(S)-Serine

6:beta-Hydroxy-L-alanine

7:beta-Hydroxyalanine

8:L-(-)-Serine

9:L-2-Amino-3-hydroxypropionic acid

10:L-3-Hydroxy-2-aminopropionic acid

11:L-3-Hydroxy-alanine

12:L-Ser

13:L-Serin

14:S

15:Ser

16:SERINE

17:(2S)-2-Amino-3-hydroxypropanoate

18:(S)-2-Amino-3-hydroxypropanoate

19:(S)-a-Amino-b-hydroxypropionate

20:(S)-a-Amino-b-hydroxypropionic acid

21:(S)-alpha-Amino-beta-hydroxypropionate

22:(S)-Α-amino-β-hydroxypropionate

23:(S)-Α-amino-β-hydroxypropionic acid

24:b-Hydroxy-L-alanine

25:Β-hydroxy-L-alanine

26:b-Hydroxyalanine

27:Β-hydroxyalanine

28:L-2-Amino-3-hydroxypropionate

29:L-3-Hydroxy-2-aminopropionate

30:(-)-Serine

31:(S)-2-Amino-3-hydroxy-propanoate

32:(S)-2-Amino-3-hydroxy-propanoic acid

33:(S)-b-Amino-3-hydroxypropionate

34:(S)-b-Amino-3-hydroxypropionic acid

35:(S)-beta-Amino-3-hydroxypropionate

36:(S)-beta-Amino-3-hydroxypropionic acid

37:2-Amino-3-hydroxypropanoate

38:2-Amino-3-hydroxypropanoic acid

39:3-Hydroxy-L-alanine

40:L Serine

41:(3R,3'r,6S)-4,5-DIDEHYDRO-5,6-dihydro-BETA,BETA-carotene-3,3'-diol

42:Bo-xan

43:e 161b

44:Xanthophyll

45:(3R,3'r,6S)-4,5-DIDEHYDRO-5,6-dihydro-b,b-carotene-3,3'-diol

46:(3R,3'r,6S)-4,5-DIDEHYDRO-5,6-dihydro-β,β-carotene-3,3'-diol

化学式

C3H7NO3

平均分子量

105.0926

等位分子量

105.042593095

化学名称

(2S)-2-amino-3-hydroxypropanoic acid

传统名称

L-serine

CAS 登记号

56-45-1

代谢物结构字符串

N[C@@H](CO)C(O)=O

inchi标识符

InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1

印记键

MTCFGRXMJLQNBG-REOHCLBHSA-N

分类学

description: belongs to the class of organic compounds known as serine and derivatives. Serine and derivatives are compounds containing serine or a derivative thereof resulting from reaction of serine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.

description:Serine and derivatives

kingdom:Organic compounds

super_class:Organic acids and derivatives

class:Carboxylic acids and derivatives

sub_class:Amino acids, peptides, and analogues

molecular_framework:Aliphatic acyclic compounds

1:Amino acids

2:Beta hydroxy acids and derivatives

3:Carbonyl compounds

4:Carboxylic acids

5:Hydrocarbon derivatives

6:L-alpha-amino acids

7:Monoalkylamines

8:Monocarboxylic acids and derivatives

9:Organic oxides

10:Organopnictogen compounds

11:Primary alcohols

12:Alcohol

13:Aliphatic acyclic compound

14:Alpha-amino acid

15:Amine

16:Amino acid

17:Beta-hydroxy acid

18:Carbonyl group

19:Carboxylic acid

20:Hydrocarbon derivative

21:Hydroxy acid

22:L-alpha-amino acid

23:Monocarboxylic acid or derivatives

24:Organic nitrogen compound

25:Organic oxide

26:Organic oxygen compound

27:Organonitrogen compound

28:Organooxygen compound

29:Organopnictogen compound

30:Primary alcohol

31:Primary aliphatic amine

32:Primary amine

33:Serine or derivatives

34:Common amino acids

35:L-alpha-amino acid

36:proteinogenic amino acid

37:serine

38:serine family amino acid

本体论

term:Physiological effect

definition:The effect on an organism physiology, resulting from its exposure to a chemical.

parent_id:

level:1

type:parent

term:Health effect

definition:A health condition or observation associated with a stimuli or with a biological activity of a chemical.

parent_id:7693

*level:2

type:parent

term:Health condition

definition:A health effect that consists on short or long-term disease, condition, disorder, syndrome or constant abnormality.

parent_id:7694

**level:3

type:parent

term:Refractory localization-related epilepsy

definition:

parent_id:7695

***level:4

type:child

synonym:Rle

term:Schizophrenia

definition:A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness. (do).

parent_id:7695

***level:4

type:child

term:Juvenile myoclonic epilepsy

definition:A adolescence-adult electroclinical syndrome that is characterized by brief, involuntary twitching of a muscle or a group of muscles (myoclonus) early in the morning with onset between 12 and 18 years. (do).

parent_id:7695

***level:4

type:child

synonym:Janz syndrome

synonym:Jme

term:Cancer

definition:A group of disorders characterized by the presense of malignant neoplasm.

parent_id:7695

***level:4

type:parent

term:Cardiac disorders

definition:Any disorder that affects the heart.

parent_id:7695

***level:4

type:parent

term:Disposition

definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.

parent_id:

level:1

type:parent

term:Route of exposure

definition:A mean by which a chemical agent comes in contact with an organism, either under intended or unintended circumstances.

parent_id:7724

*level:2

type:parent

term:Enteral

definition:Chemical exposure via the alimentary canal (mouth to anus).

parent_id:7743

**level:3

type:parent

term:Ingestion

definition:Chemical exposure facilitated by entry through the mouth.

parent_id:7744

***level:4

type:child

synonym:Digestion

term:Source

definition:Natural or synthetic origin of a chemical.

parent_id:7724

*level:2

type:parent

term:Endogenous

definition:

parent_id:7735

**level:3

type:child

term:Food

definition:

parent_id:7735

**level:3

type:child

term:Synthetic

definition:A man-made product or sample in which a chemical can be found.

parent_id:7735

**level:3

type:parent

term:Personal care product

definition:

parent_id:7742

***level:4

type:child

synonym:Pcp

synonym:Toiletries

synonym:Toiletry

synonym:Personal hygiene

synonym:Beautification product

term:Biological

definition:A living organism (species or a higher taxonomy rank), in which a chemical can be found.

parent_id:7735

**level:3

type:parent

term:Animal

definition:A living organism belonging to the kingdom animalia. it feeds on organic matter, typically having specialized sense organs and nervous system and able to respond rapidly to stimuli.

parent_id:7736

***level:4

type:child

synonym:Fauna

term:Plant

definition:A living organism belonging to the kingdom plantea. typically, it grows in a permanent site, absorbs water and inorganic substances through its roots, and synthesizes nutrients in its leaves by photosynthesis using the green pigment chlorophyll. examples incude trees, shrubs, herbs, grasses, ferns, and mosses.

parent_id:7736

***level:4

type:parent

synonym:Flora

term:Biological location

definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.

parent_id:7724

*level:2

type:parent

term:Tissue and substructures

definition:An anatomical organizational level including multiple cells yet not comprising a complete organ .

parent_id:7725

**level:3

type:parent

term:All tissues

definition:All tissues in the body of the organism.

parent_id:7729

***level:4

type:child

term:Placenta

definition:An organ present in some vertebrates during embryonic gestation that surrounds the fetus and provides it with nutrients and oxygen, facilitates gas and waste exchange between the fetus and mother, and provides parasitic cloaking from the mother's immune system by excretion of neurokinin b. (nci).

parent_id:7729

***level:4

type:child

term:Organ and components

definition:An anatomical organizational level including multiple tissues or substructures, which enables a common biological function.

parent_id:7725

**level:3

type:parent

term:Prostate

definition:The male reproductive accessory gland that produces prostatic fluid and is located adjacent to or around the urethra distal to the urinary bladder in mammals. (nci).

parent_id:7727

***level:4

type:child

synonym:Prostate gland

term:Biofluid and excreta

definition:A liquid, semi-solid or solid material originating in the body.

parent_id:7725

**level:3

type:parent

term:Urine

definition:Excretion in liquid state processed by the kidney.

parent_id:7731

***level:4

type:child

term:Saliva

definition:The watery fluid in the mouth made by the salivary glands. saliva moistens food to help digestion and it helps protect the mouth against infections. (nci).

parent_id:7731

***level:4

type:child

term:Feces

definition:The material discharged from the bowel during defecation. It consists of undigested food, intestinal mucus, epithelial cells, and bacteria.

parent_id:7731

***level:4

type:child

synonym:Fecal

synonym:Stool

synonym:Faecal

synonym:Faeces

term:Blood

definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.

parent_id:7731

***level:4

type:child

term:Sweat

definition:Secretion produced by a sweat gland.

parent_id:7731

***level:4

type:child

term:Cerebrospinal fluid

definition:The fluid that is contained within the brain ventricles, the subarachnoid space and the central canal of the spinal cord. (nci).

parent_id:7731

***level:4

type:child

synonym:Csf

term:Subcellular

definition:An anatomical organizational level including a component within a biological cell .

parent_id:7725

**level:3

type:parent

term:Cytoplasm

definition:The portion of the cell contained within the plasma membrane but excluding the nucleus.

parent_id:7730

***level:4

type:child

synonym:Cytoplasma

term:Mitochondria

definition:

parent_id:7730

***level:4

type:child

term:Peroxisome

definition:A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. (Gene Ontology).

parent_id:7730

***level:4

type:child

synonym:Peroxisome vesicle

synonym:Peroxisomal

term:Cell and elements

definition:An anatomical organizational level comprising of a single cell (or a fragment in some exceptions). a cell is defined by its type or function. it is the smallest unit of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid.

parent_id:7725

**level:3

type:parent

term:Extracellular

definition:The space external to the outermost structure of a cell.

parent_id:7732

***level:4

type:child

synonym:Extracellular region

term:Process

definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.

parent_id:

level:1

type:parent

term:Naturally occurring process

definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.

parent_id:7659

*level:2

type:parent

term:Biological process

definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.

parent_id:7660

**level:3

type:parent

term:Biochemical pathway

definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.

parent_id:7661

***level:4

type:parent

term:Role

definition:The purpose or function assumed by a chemical, either naturally or as intended by humans .

parent_id:

level:1

type:parent

term:Industrial application

definition:The assumed function of a chemical utilized by human.

parent_id:7671

*level:2

type:parent

term:Food and nutrition

definition:A chemical purpose related to manufacturing of food and nutrition products.

parent_id:7678

**level:3

type:child

term:Personal care products

definition:Cosmetics and personal hygene products in which a chemical was incorportaed during the manufacturing process.

parent_id:7678

**level:3

type:child

term:Pharmaceutical industry

definition:A pharmacologic activity for which a chemical substance is utilized owing to its biological role.

parent_id:7678

**level:3

type:parent

term:Pharmaceutical

definition:

parent_id:7679

***level:4

type:child

状态

Solid

实验性质

kind:water_solubility

value:425.0 mg/mL

source:

kind:logp

value:-3.07

source:HANSCH,C ET AL. (1995)

kind:melting_point

value:228 °C

source:

预测性质

kind:logp

value:-3.42

source:ALOGPS

kind:logs

value:0.66

source:ALOGPS

kind:solubility

value:480 g/L

source:ALOGPS

kind:logp

value:-3.9

source:ChemAxon

kind:pka_strongest_acidic

value:2.03

source:ChemAxon

kind:pka_strongest_basic

value:8.93

source:ChemAxon

kind:iupac

value:(2S)-2-amino-3-hydroxypropanoic acid

source:ChemAxon

kind:average_mass

value:105.0926

source:ChemAxon

kind:mono_mass

value:105.042593095

source:ChemAxon

10:

kind:smiles

value:N[C@@H](CO)C(O)=O

source:ChemAxon

11:

kind:formula

value:C3H7NO3

source:ChemAxon

12:

kind:inchi

value:InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1

source:ChemAxon

13:

kind:inchikey

value:MTCFGRXMJLQNBG-REOHCLBHSA-N

source:ChemAxon

14:

kind:polar_surface_area

value:83.55

source:ChemAxon

15:

kind:refractivity

value:22.04

source:ChemAxon

16:

kind:polarizability

value:9.39

source:ChemAxon

17:

kind:rotatable_bond_count

value:2

source:ChemAxon

18:

kind:acceptor_count

value:4

source:ChemAxon

19:

kind:donor_count

value:3

source:ChemAxon

20:

kind:physiological_charge

value:0

source:ChemAxon

21:

kind:formal_charge

value:0

source:ChemAxon

22:

kind:number_of_rings

value:0

source:ChemAxon

23:

kind:bioavailability

value:Yes

source:ChemAxon

24:

kind:rule_of_five

value:Yes

source:ChemAxon

25:

kind:ghose_filter

value:No

source:ChemAxon

26:

kind:veber_rule

value:No

source:ChemAxon

27:

kind:mddr_like_rule

value:No

source:ChemAxon

type:Specdb::MsMs

spectrum_id:295

type:Specdb::MsMs

spectrum_id:296

type:Specdb::MsMs

spectrum_id:297

type:Specdb::MsMs

spectrum_id:3436

type:Specdb::MsMs

spectrum_id:3437

type:Specdb::MsMs

spectrum_id:3438

type:Specdb::MsMs

spectrum_id:3439

type:Specdb::MsMs

spectrum_id:3440

type:Specdb::MsMs

spectrum_id:3441

10:

type:Specdb::MsMs

spectrum_id:3442

11:

type:Specdb::MsMs

spectrum_id:3443

12:

type:Specdb::MsMs

spectrum_id:3444

13:

type:Specdb::MsMs

spectrum_id:3445

14:

type:Specdb::MsMs

spectrum_id:3446

15:

type:Specdb::MsMs

spectrum_id:3447

16:

type:Specdb::MsMs

spectrum_id:3448

17:

type:Specdb::MsMs

spectrum_id:3449

18:

type:Specdb::MsMs

spectrum_id:3450

19:

type:Specdb::MsMs

spectrum_id:3451

20:

type:Specdb::MsMs

spectrum_id:3452

21:

type:Specdb::MsMs

spectrum_id:3453

22:

type:Specdb::MsMs

spectrum_id:3454

23:

type:Specdb::MsMs

spectrum_id:3455

24:

type:Specdb::MsMs

spectrum_id:3456

25:

type:Specdb::MsMs

spectrum_id:3457

26:

type:Specdb::EiMs

spectrum_id:1977

27:

type:Specdb::NmrTwoD

spectrum_id:987

28:

type:Specdb::NmrTwoD

spectrum_id:1193

29:

type:Specdb::NmrOneD

spectrum_id:1157

30:

type:Specdb::NmrOneD

spectrum_id:142770

31:

type:Specdb::NmrOneD

spectrum_id:142771

32:

type:Specdb::NmrOneD

spectrum_id:142772

33:

type:Specdb::NmrOneD

spectrum_id:142773

34:

type:Specdb::NmrOneD

spectrum_id:142774

35:

type:Specdb::NmrOneD

spectrum_id:142775

36:

type:Specdb::NmrOneD

spectrum_id:142776

37:

type:Specdb::NmrOneD

spectrum_id:142777

38:

type:Specdb::NmrOneD

spectrum_id:142778

39:

type:Specdb::NmrOneD

spectrum_id:142779

40:

type:Specdb::NmrOneD

spectrum_id:142780

41:

type:Specdb::NmrOneD

spectrum_id:142781

42:

type:Specdb::NmrOneD

spectrum_id:142782

43:

type:Specdb::NmrOneD

spectrum_id:142783

44:

type:Specdb::NmrOneD

spectrum_id:142784

45:

type:Specdb::NmrOneD

spectrum_id:142785

46:

type:Specdb::NmrOneD

spectrum_id:142786

47:

type:Specdb::NmrOneD

spectrum_id:142787

48:

type:Specdb::NmrOneD

spectrum_id:142788

49:

type:Specdb::NmrOneD

spectrum_id:142789

50:

type:Specdb::CMs

spectrum_id:429

51:

type:Specdb::CMs

spectrum_id:430

52:

type:Specdb::CMs

spectrum_id:431

53:

type:Specdb::CMs

spectrum_id:432

54:

type:Specdb::CMs

spectrum_id:433

55:

type:Specdb::CMs

spectrum_id:1073

56:

type:Specdb::CMs

spectrum_id:3020

57:

type:Specdb::CMs

spectrum_id:30057

58:

type:Specdb::CMs

spectrum_id:30059

59:

type:Specdb::CMs

spectrum_id:30211

60:

type:Specdb::CMs

spectrum_id:30315

61:

type:Specdb::CMs

spectrum_id:30611

62:

type:Specdb::CMs

spectrum_id:30612

63:

type:Specdb::CMs

spectrum_id:30731

64:

type:Specdb::CMs

spectrum_id:30867

65:

type:Specdb::CMs

spectrum_id:31057

66:

type:Specdb::CMs

spectrum_id:37344

67:

type:Specdb::CMs

spectrum_id:137692

68:

type:Specdb::CMs

spectrum_id:145426

光谱

生物学性质

cellular:(1):Cytoplasm

cellular:(2):Extracellular

cellular:(3):Mitochondria

cellular:(4):Peroxisome

biospecimen:(1):Blood

biospecimen:(2):Cerebrospinal Fluid (CSF)

biospecimen:(3):Feces

biospecimen:(4):Saliva

biospecimen:(5):Sweat

biospecimen:(6):Urine

tissue:(1):All Tissues

tissue:(2):Placenta

tissue:(3):Prostate

[1]:

name:3-Phosphoglycerate dehydrogenase deficiency

smpdb_id:SMP00721

kegg_map_id:

[2]:

name:Cystathionine Beta-Synthase Deficiency

smpdb_id:SMP00177

kegg_map_id:

[3]:

name:Dihydropyrimidine Dehydrogenase Deficiency (DHPD)

smpdb_id:SMP00179

kegg_map_id:

[4]:

name:Dimethylglycine Dehydrogenase Deficiency

smpdb_id:SMP00242

kegg_map_id:

[5]:

name:Dimethylglycine Dehydrogenase Deficiency

smpdb_id:SMP00484

kegg_map_id:

[6]:

name:Fabry disease

smpdb_id:SMP00525

kegg_map_id:

[7]:

name:Gamma-cystathionase deficiency (CTH)

smpdb_id:SMP00514

kegg_map_id:

[8]:

name:Gaucher Disease

smpdb_id:SMP00349

kegg_map_id:

[9]:

name:Globoid Cell Leukodystrophy

smpdb_id:SMP00348

kegg_map_id:

[10]:

name:Glycine N-methyltransferase Deficiency

smpdb_id:SMP00222

kegg_map_id:

[11]:

name:Glycine, serine and threonine metabolism

smpdb_id:

kegg_map_id:map00260

[12]:

name:Homocysteine Degradation

smpdb_id:SMP00455

kegg_map_id:

[13]:

name:Homocystinuria, cystathionine beta-synthase deficiency

smpdb_id:SMP00515

kegg_map_id:

[14]:

name:Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation type

smpdb_id:SMP00570

kegg_map_id:

[15]:

name:Hyperglycinemia, non-ketotic

smpdb_id:SMP00485

kegg_map_id:

[16]:

name:Hypermethioninemia

smpdb_id:SMP00341

kegg_map_id:

[17]:

name:Krabbe disease

smpdb_id:SMP00526

kegg_map_id:

[18]:

name:Metachromatic Leukodystrophy (MLD)

smpdb_id:SMP00347

kegg_map_id:

[19]:

name:Methionine Adenosyltransferase Deficiency

smpdb_id:SMP00221

kegg_map_id:

[20]:

name:Methionine Metabolism

smpdb_id:SMP00033

kegg_map_id:map00270

[21]:

name:Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)

smpdb_id:SMP00340

kegg_map_id:

[22]:

name:Nitrogen metabolism

smpdb_id:

kegg_map_id:map00910

[23]:

name:Non Ketotic Hyperglycinemia

smpdb_id:SMP00223

kegg_map_id:

[24]:

name:Phosphatidylethanolamine Biosynthesis

smpdb_id:SMP29731

kegg_map_id:

[25]:

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smpdb_id:SMP02313

kegg_map_id:

[949]:

name:Sarcosinemia

smpdb_id:SMP00244

kegg_map_id:

[950]:

name:Selenocompound metabolism

smpdb_id:

kegg_map_id:map00450

[951]:

name:Starch and sucrose metabolism

smpdb_id:

kegg_map_id:map00500

正常浓度

biospecimen:Blood

concentration_value:62-161

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

biospecimen:Blood

concentration_value:159.8 +/- 26.6

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

biospecimen:Blood

concentration_value:76-180

concentration_units:uM

subject_age:Infant (1 - 3 months old)

subject_sex:Both

subject_condition:Normal

biospecimen:Blood

concentration_value:77-178

concentration_units:uM

subject_age:Children (3 months - 6 years old)

subject_sex:Both

subject_condition:Normal

biospecimen:Blood

concentration_value:71-181

concentration_units:uM

subject_age:Children (6 - 18 years old)

subject_sex:Both

subject_condition:Normal

biospecimen:Blood

concentration_value:173.2 +/- 51.3

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

biospecimen:Blood

concentration_value:70-140

concentration_units:uM

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

biospecimen:Blood

concentration_value:114.0 (95.0-133.0)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

biospecimen:Blood

concentration_value:134.0 +/- 38.0

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Not Specified

subject_condition:Normal

10:

biospecimen:Blood

concentration_value:121.0 +/- 25.0

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Male

subject_condition:Normal

11:

biospecimen:Blood

concentration_value:127.0 +/- 27.0

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Female

subject_condition:Normal

12:

biospecimen:Blood

concentration_value:127-211

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Not Specified

subject_condition:Normal

13:

biospecimen:Blood

concentration_value:114.0 +/- 23.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

14:

biospecimen:Blood

concentration_value:60-300

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

15:

biospecimen:Blood

concentration_value:127.0 +/- 29.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

16:

biospecimen:Blood

concentration_value:50-350

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Not Specified

subject_condition:Normal

17:

biospecimen:Blood

concentration_value:121.0 +/- 14.0

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

18:

biospecimen:Blood

concentration_value:70-187

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

19:

biospecimen:Blood

concentration_value:137.0 +/- 35.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

20:

biospecimen:Blood

concentration_value:70-187

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

21:

biospecimen:Blood

concentration_value:142.0 +/- 35.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

22:

biospecimen:Blood

concentration_value:25-57

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

23:

biospecimen:Blood

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

24:

biospecimen:Blood

concentration_value:74-448

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Not Specified

subject_condition:Normal

25:

biospecimen:Blood

concentration_value:70.3 +/- 19.6

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

26:

biospecimen:Blood

concentration_value:60.00-180.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

27:

biospecimen:Blood

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

28:

biospecimen:Blood

concentration_value:115.1 +/- 25.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

29:

biospecimen:Blood

concentration_value:24-172

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

30:

biospecimen:Blood

concentration_value:50-200

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

31:

biospecimen:Blood

concentration_value:99-395

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

32:

biospecimen:Blood

concentration_value:143.3(129.3-161.6)

concentration_units:uM

subject_age:Children (1-13 uears old)

subject_sex:Both

subject_condition:Normal

33:

biospecimen:Blood

concentration_value:236.0 +/- 6.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

34:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:28.9 (20.7-37.0)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

35:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:24-44

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

36:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:17-41

concentration_units:uM

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

37:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:24.5 +/- 4.4

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

38:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:42 +/- 18

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

39:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:52.0 (25.0-105.0)

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

40:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:42.4 +/- 15.1

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

41:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:28.1 +/- 4.7

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

42:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:30.2 +/- 3.8

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

43:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:56-103

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Not Specified

subject_condition:Normal

44:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:35-80

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

45:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:35-80

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Not Specified

subject_condition:Normal

46:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:35-80

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

47:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:20-40

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

48:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:41(24-59)

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

49:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:44(26-63)

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

50:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:52(31-74)

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Not Specified

subject_condition:Normal

51:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:59(35-82)

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Not Specified

subject_condition:Normal

52:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:32.8 +/- 8.6

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

53:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:25-61

concentration_units:uM

subject_age:Children (0 - 10 years old)

subject_sex:Both

subject_condition:Normal

54:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:22-41

concentration_units:uM

subject_age:Adolescent (>11 years old)

subject_sex:Both

subject_condition:Normal

55:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:7.6 +/- 0.67

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

56:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

57:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

58:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Children (1-13 years old)

subject_sex:Both

subject_condition:Normal

59:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

60:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

61:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

62:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Children (6 - 18 years old)

subject_sex:Both

subject_condition:Normal

63:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

64:

biospecimen:Feces

concentration_value:220 +/- 170

concentration_units:nmol/g wet feces

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

65:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

66:

biospecimen:Feces

concentration_value:50 +/- 50

concentration_units:nmol/g wet feces

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

67:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

68:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

69:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

70:

biospecimen:Saliva

concentration_value:7.77 +/- 4.10

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

71:

biospecimen:Saliva

concentration_value:8.91 +/- 9.17

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

72:

biospecimen:Saliva

concentration_value:10.0 +/- 6.21

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

73:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

74:

biospecimen:Saliva

concentration_value:10.8 +/- 1.3

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

75:

biospecimen:Saliva

concentration_value:6.8 +/- 2.4

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

76:

biospecimen:Saliva

concentration_value:28.1 +/- 60.9

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

77:

biospecimen:Saliva

concentration_value:15.1 +/- 10.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

78:

biospecimen:Saliva

concentration_value:40.8 +/- 17.9

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

79:

biospecimen:Saliva

concentration_value:10.7 +/- 4.8

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

80:

biospecimen:Saliva

concentration_value:31.7 +/- 24.5

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

81:

biospecimen:Saliva

concentration_value:32.0 +/- 41.4

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

82:

biospecimen:Saliva

concentration_value:38.79 +/- 21.03

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

83:

biospecimen:Sweat

concentration_value:580-3020

concentration_units:uM

subject_age:Adult (60 years old)

subject_sex:Male

subject_condition:Normal

84:

biospecimen:Sweat

concentration_value:780

concentration_units:uM

subject_age:Adult (40 years old)

subject_sex:Male

subject_condition:Normal

85:

biospecimen:Sweat

concentration_value:

concentration_units:

subject_age:Adult

subject_sex:Both

subject_condition:Normal

86:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

87:

biospecimen:Urine

concentration_value:32.19-145.5

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

88:

biospecimen:Urine

concentration_value:76.86 +/- 22.72

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Female

subject_condition:Normal

89:

biospecimen:Urine

concentration_value:79.08 +/- 29.96

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Male

subject_condition:Normal

90:

biospecimen:Urine

concentration_value:19.0 (10.4-35.8)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

91:

biospecimen:Urine

concentration_value:33.6

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

92:

biospecimen:Urine

concentration_value:11.88-95.70

concentration_units:umol/mmol creatinine

subject_age:Adolescent (13-18 years old)

subject_sex:Not Specified

subject_condition:Normal

93:

biospecimen:Urine

concentration_value:10.97-61.084

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

94:

biospecimen:Urine

concentration_value:19.04-47.60

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

95:

biospecimen:Urine

concentration_value:2.04-507.03

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

96:

biospecimen:Urine

concentration_value:20-38

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

97:

biospecimen:Urine

concentration_value:85.062 +/- 43.302

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

98:

biospecimen:Urine

concentration_value:25.3 (11.6-53.4)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

99:

biospecimen:Urine

concentration_value:33.83

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

100:

biospecimen:Urine

concentration_value:124.48 - 407.24

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

101:

biospecimen:Urine

concentration_value:58.00 - 279.03

concentration_units:umol/mmol creatinine

subject_age:Infant (1 - 6 months old)

subject_sex:Both

subject_condition:Normal

102:

biospecimen:Urine

concentration_value:69.53 - 196.16

concentration_units:umol/mmol creatinine

subject_age:Infant (6 months - <1 year old)

subject_sex:Both

subject_condition:Normal

103:

biospecimen:Urine

concentration_value:62.30 - 177.28

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 2 years old)

subject_sex:Both

subject_condition:Normal

104:

biospecimen:Urine

concentration_value:43.42 - 133.64

concentration_units:umol/mmol creatinine

subject_age:Children (2 - 4 years old)

subject_sex:Both

subject_condition:Normal

105:

biospecimen:Urine

concentration_value:30.30 - 132.17

concentration_units:umol/mmol creatinine

subject_age:Children (4 - 13 years old)

subject_sex:Both

subject_condition:Normal

106:

biospecimen:Urine

concentration_value:10.18 - 69.53

concentration_units:umol/mmol creatinine

subject_age:Adolescent (13 - 21 years old)

subject_sex:Both

subject_condition:Normal

107:

biospecimen:Urine

concentration_value:9.95 - 71.00

concentration_units:umol/mmol creatinine

subject_age:Adult (>21 years old)

subject_sex:Both

subject_condition:Normal

108:

biospecimen:Urine

concentration_value:32.13-221.60

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

109:

biospecimen:Urine

concentration_value:7.9 +/- 2.6

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

110:

biospecimen:Urine

concentration_value:8.8 +/- 1.8

concentration_units:umol/mmol creatinine

subject_age:Infant (1 - 6 months old)

subject_sex:Both

subject_condition:Normal

111:

biospecimen:Urine

concentration_value:8.8 +/- 2.2

concentration_units:umol/mmol creatinine

subject_age:Infant (6 months - <1 year old)

subject_sex:Both

subject_condition:Normal

112:

biospecimen:Urine

concentration_value:20-50

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

113:

biospecimen:Urine

concentration_value:28.0389-327.648

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

114:

biospecimen:Urine

concentration_value:38.41-239.55

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

115:

biospecimen:Urine

concentration_value:27.38 +/- 9.54

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

116:

biospecimen:Urine

concentration_value:24.5 (12.3-50.2)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

117:

biospecimen:Urine

concentration_value:180 (25.33-334.67)

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

118:

biospecimen:Urine

concentration_value:8.9 +/- 4.6

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Female

subject_condition:Normal

119:

biospecimen:Urine

concentration_value:30.0 +/- 13.6

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

120:

biospecimen:Urine

concentration_value:26.0 +/- 10.0

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

121:

biospecimen:Urine

concentration_value:20.25-145.36

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

122:

biospecimen:Urine

concentration_value:28.5 (12.5-44.4)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

123:

biospecimen:Urine

concentration_value:39-306

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

124:

biospecimen:Urine

concentration_value:18-34

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

125:

biospecimen:Urine

concentration_value:74.67 +/- 37.74

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

126:

biospecimen:Urine

concentration_value:31.6

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

127:

biospecimen:Urine

concentration_value:79.5556 +/- 24.8501

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

128:

biospecimen:Urine

concentration_value:248.73 +/- 180.90

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

129:

biospecimen:Urine

concentration_value:440.93 +/- 260.04

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

130:

biospecimen:Urine

concentration_value:610.52 +/- 327.87

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

131:

biospecimen:Urine

concentration_value:17.31-86.54

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

异常浓度

biospecimen:Blood

concentration_value:135.3 (45.2)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Down syndrome pregnancy

biospecimen:Blood

concentration_value:148.4 (52.2)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

biospecimen:Blood

concentration_value:92.4 +/- 29.9

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Obesity

biospecimen:Blood

concentration_value:103.3 +/- 28.3

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Obesity

biospecimen:Blood

concentration_value:56-63

concentration_units:uM

patient_age:Adolescent (13-18 years old)

patient_sex:Both

patient_information:3-Phosphoglycerate Dehydrogenase Deficiency

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Lung cancer

biospecimen:Blood

concentration_value:104.0 (101.0-107.0)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Refractory localization-related epilepsy (RLE)

biospecimen:Blood

concentration_value:140.0 (131.0-148.0)

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Juvenile myoclonic epilepsy (JME)

biospecimen:Blood

concentration_value:118.06 +/- 37.23

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy with fetuses with trisomy 18

10:

biospecimen:Blood

concentration_value:132.03 +/- 50.64

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

11:

biospecimen:Blood

concentration_value:115.5 (23.8)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Early preeclampsia

12:

biospecimen:Blood

concentration_value:150.3 (84.3)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

13:

biospecimen:Blood

concentration_value:19

concentration_units:uM

patient_age:Newborn (0-30 days old)

patient_sex:Male

patient_information:Neu-Laxova Syndrome 1

14:

biospecimen:Blood

concentration_value:51

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Male

patient_information:Phosphoserine Aminotransferase Deficiency

15:

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

16:

biospecimen:Blood

concentration_value:30

concentration_units:uM

patient_age:Newborn (0-30 days old)

patient_sex:Female

patient_information:Phosphoserine Aminotransferase Deficiency

17:

biospecimen:Blood

concentration_value:29-55

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Male

patient_information:Phosphoserine Phosphatase Deficiency

18:

biospecimen:Blood

concentration_value:53-80

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Male

patient_information:Phosphoserine Phosphatase Deficiency

19:

biospecimen:Blood

concentration_value:18

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Male

patient_information:Phosphoserine Phosphatase Deficiency

20:

biospecimen:Blood

concentration_value:50

concentration_units:uM

patient_age:Newborn (0-30 days old)

patient_sex:Male

patient_information:Neu-Laxova Syndrome 1

21:

biospecimen:Blood

concentration_value:197.9 +/- 46.4

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Schizophrenia

22:

biospecimen:Blood

concentration_value:75.47 (22.9)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy with fetus having congenital heart defect

23:

biospecimen:Blood

concentration_value:77.55 (23.11)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

24:

biospecimen:Blood

concentration_value:148.4 (103.4)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Late-onset preeclampsia

25:

biospecimen:Blood

concentration_value:158.6 (92.2)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

26:

biospecimen:Blood

concentration_value:165.8(138.0-208.1)

concentration_units:uM

patient_age:Children (1-13 uears old)

patient_sex:Both

patient_information:Environmental enteric dysfunction

27:

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Schizophrenia

28:

biospecimen:Blood

concentration_value:0.21 +/- 0.024

concentration_units:uM

patient_age:Elderly (>65 years old)

patient_sex:Both

patient_information:Alzheimer's disease

29:

biospecimen:Blood

concentration_value:222.4

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Female

patient_information:Sarcosinemia

30:

biospecimen:Blood

concentration_value:263

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Male

patient_information:Fumaric aciduria

31:

biospecimen:Blood

concentration_value:116-145

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Sarcosinemia

32:

biospecimen:Blood

concentration_value:221.0 +/- 8.0

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Heart failure

33:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:28-32

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Sarcosinemia

34:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:9

concentration_units:uM

patient_age:Adolescent (13-18 years old)

patient_sex:Male

patient_information:3-Phosphoglycerate Dehydrogenase Deficiency

35:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:38.3 +/- 15.5

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Not Specified

patient_information:Leukemia

36:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:31.9 +/- 8.8

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Not Specified

patient_information:Leukemia

37:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:3

concentration_units:uM

patient_age:Newborn (0-30 days old)

patient_sex:Male

patient_information:Neu-Laxova Syndrome 1

38:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:18

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Male

patient_information:Phosphoserine Aminotransferase Deficiency

39:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:5

concentration_units:uM

patient_age:Newborn (0-30 days old)

patient_sex:Female

patient_information:Phosphoserine Aminotransferase Deficiency

40:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:6

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Male

patient_information:Phosphoserine Phosphatase Deficiency

41:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:8

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Male

patient_information:Phosphoserine Phosphatase Deficiency

42:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:6-11

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Not Specified

patient_information:Serine deficiency syndrome, infantile

43:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:7.5 +/- 0.87

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Schizophrenia

44:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

45:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal Cancer

46:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

47:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Autism

48:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Not Specified

patient_sex:Not Specified

patient_information:Cryptosporidium infection

49:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

50:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Irritable bowel syndrome

51:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Ulcerative colitis

52:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Both

patient_information:Crohns disease

53:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Both

patient_information:Ulcerative colitis

54:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

55:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Crohns disease

56:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Ulcerative colitis

57:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Unclassified IBD

58:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

59:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

60:

biospecimen:Saliva

concentration_value:26.01 +/- 5.43

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Alzheimer's disease

61:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Oral cancer

62:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Breast cancer

63:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Not Specified

patient_information:Pancreatic cancer

64:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Not Specified

patient_information:Periodontal diseases

65:

biospecimen:Saliva

concentration_value:23.41 +/- 14.42

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Frontotemporal lobe dementia

66:

biospecimen:Saliva

concentration_value:21.55 +/- 1.41

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Lewy body disease

67:

biospecimen:Urine

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Bladder cancer

68:

biospecimen:Urine

concentration_value:93.066 +/- 81.705

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Eosinophilic esophagitis

69:

biospecimen:Urine

concentration_value:0.0041 - 0.0122

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:ADPKD

70:

biospecimen:Urine

concentration_value:147.06

concentration_units:umol/mmol creatinine

patient_age:Infant (0-1 year old)

patient_sex:Female

patient_information:Sarcosinemia

71:

biospecimen:Urine

concentration_value:341.600-735

concentration_units:umol/mmol creatinine

patient_age:Infant (0-1 year old)

patient_sex:Not Specified

patient_information:Fumaric aciduria

72:

biospecimen:Urine

concentration_value:38-77

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Sarcosinemia

73:

biospecimen:Urine

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

74:

biospecimen:Urine

concentration_value:69.0205 +/- 26.7146

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Eosinophilic esophagitis

75:

biospecimen:Urine

concentration_value:63.6702 +/- 49.05

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Gastroesophageal reflux disease

疾病参考

name:Refractory localization-related epilepsy

omim_id:

[1]:

reference_text:Rainesalo S, Keranen T, Palmio J, Peltola J, Oja SS, Saransaari P: Plasma and cerebrospinal fluid amino acids in epileptic patients. Neurochem Res. 2004 Jan;29(1):319-24.

pubmed_id:14992292

name:Juvenile myoclonic epilepsy

omim_id:606904

[1]:

reference_text:Rainesalo S, Keranen T, Palmio J, Peltola J, Oja SS, Saransaari P: Plasma and cerebrospinal fluid amino acids in epileptic patients. Neurochem Res. 2004 Jan;29(1):319-24.

pubmed_id:14992292

name:Alzheimer's disease

omim_id:104300

[1]:

reference_text:Fonteh AN, Harrington RJ, Tsai A, Liao P, Harrington MG: Free amino acid and dipeptide changes in the body fluids from Alzheimer's disease subjects. Amino Acids. 2007 Feb;32(2):213-24. Epub 2006 Oct 10.

pubmed_id:17031479

[2]:

reference_text:Selley ML, Close DR, Stern SE: The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer's disease. Neurobiol Aging. 2002 May-Jun;23(3):383-8.

pubmed_id:11959400

[3]:

reference_text:Shetty HU, Holloway HW, Schapiro MB: Cerebrospinal fluid and plasma distribution of myo-inositol and other polyols in Alzheimer disease. Clin Chem. 1996 Feb;42(2):298-302.

pubmed_id:8595727

[4]:

reference_text:Jia JP, Jia JM, Zhou WD, Xu M, Chu CB, Yan X, Sun YX: Differential acetylcholine and choline concentrations in the cerebrospinal fluid of patients with Alzheimer's disease and vascular dementia. Chin Med J (Engl). 2004 Aug;117(8):1161-4.

pubmed_id:15361288

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reference_text:Redjems-Bennani N, Jeandel C, Lefebvre E, Blain H, Vidailhet M, Gueant JL: Abnormal substrate levels that depend upon mitochondrial function in cerebrospinal fluid from Alzheimer patients. Gerontology. 1998;44(5):300-4.

pubmed_id:9693263

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reference_text:Walter A, Korth U, Hilgert M, Hartmann J, Weichel O, Hilgert M, Fassbender K, Schmitt A, Klein J: Glycerophosphocholine is elevated in cerebrospinal fluid of Alzheimer patients. Neurobiol Aging. 2004 Nov-Dec;25(10):1299-303.

pubmed_id:15465626

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reference_text:Leoni V, Masterman T, Mousavi FS, Wretlind B, Wahlund LO, Diczfalusy U, Hillert J, Bjorkhem I: Diagnostic use of cerebral and extracerebral oxysterols. Clin Chem Lab Med. 2004 Feb;42(2):186-91.

pubmed_id:15061359

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reference_text:Raskind MA, Peskind ER, Holmes C, Goldstein DS: Patterns of cerebrospinal fluid catechols support increased central noradrenergic responsiveness in aging and Alzheimer's disease. Biol Psychiatry. 1999 Sep 15;46(6):756-65.

pubmed_id:10494443

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reference_text:Lovell MA, Markesbery WR: Ratio of 8-hydroxyguanine in intact DNA to free 8-hydroxyguanine is increased in Alzheimer disease ventricular cerebrospinal fluid. Arch Neurol. 2001 Mar;58(3):392-6.

pubmed_id:11255442

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reference_text:Bar KJ, Franke S, Wenda B, Muller S, Kientsch-Engel R, Stein G, Sauer H: Pentosidine and N(epsilon)-(carboxymethyl)-lysine in Alzheimer's disease and vascular dementia. Neurobiol Aging. 2003 Mar-Apr;24(2):333-8.

pubmed_id:12498967

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reference_text:Serot JM, Barbe F, Arning E, Bottiglieri T, Franck P, Montagne P, Nicolas JP: Homocysteine and methylmalonic acid concentrations in cerebrospinal fluid: relation with age and Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2005 Nov;76(11):1585-7.

pubmed_id:16227558

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reference_text:Molina JA, Jimenez-Jimenez FJ, Aguilar MV, Meseguer I, Mateos-Vega CJ, Gonzalez-Munoz MJ, de Bustos F, Porta J, Orti-Pareja M, Zurdo M, Barrios E, Martinez-Para MC: Cerebrospinal fluid levels of transition metals in patients with Alzheimer's disease. J Neural Transm (Vienna). 1998;105(4-5):479-88.

pubmed_id:9720975

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reference_text:Molina JA, Jimenez-Jimenez FJ, Hernanz A, Fernandez-Vivancos E, Medina S, de Bustos F, Gomez-Escalonilla C, Sayed Y: Cerebrospinal fluid levels of thiamine in patients with Alzheimer's disease. J Neural Transm (Vienna). 2002 Jul;109(7-8):1035-44.

pubmed_id:12111441

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reference_text:Bocca B, Forte G, Petrucci F, Pino A, Marchione F, Bomboi G, Senofonte O, Giubilei F, Alimonti A: Monitoring of chemical elements and oxidative damage in patients affected by Alzheimer's disease. Ann Ist Super Sanita. 2005;41(2):197-203.

pubmed_id:16244393

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reference_text:Kristensen MO, Gulmann NC, Christensen JE, Ostergaard K, Rasmussen K: Serum cobalamin and methylmalonic acid in Alzheimer dementia. Acta Neurol Scand. 1993 Jun;87(6):475-81.

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reference_text:Abe T, Tohgi H, Isobe C, Murata T, Sato C: Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease. J Neurosci Res. 2002 Nov 1;70(3):447-50.

pubmed_id:12391605

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reference_text:Reichman ME, Judd JT, Longcope C, Schatzkin A, Clevidence BA, Nair PP, Campbell WS, Taylor PR: Effects of alcohol consumption on plasma and urinary hormone concentrations in premenopausal women. J Natl Cancer Inst. 1993 May 5;85(9):722-7.

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reference_text:Hozumi I, Hasegawa T, Honda A, Ozawa K, Hayashi Y, Hashimoto K, Yamada M, Koumura A, Sakurai T, Kimura A, Tanaka Y, Satoh M, Inuzuka T: Patterns of levels of biological metals in CSF differ among neurodegenerative diseases. J Neurol Sci. 2011 Apr 15;303(1-2):95-9. doi: 10.1016/j.jns.2011.01.003. Epub 2011 Feb 2.

pubmed_id:21292280

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reference_text:Motawaj M, Peoc'h K, Callebert J, Arrang JM: CSF levels of the histamine metabolite tele-methylhistamine are only slightly decreased in Alzheimer's disease. J Alzheimers Dis. 2010;22(3):861-71. doi: 10.3233/JAD-2010-100381.

pubmed_id:20858978

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reference_text:Smach MA, Jacob N, Golmard JL, Charfeddine B, Lammouchi T, Ben Othman L, Dridi H, Bennamou S, Limem K: Folate and homocysteine in the cerebrospinal fluid of patients with Alzheimer's disease or dementia: a case control study. Eur Neurol. 2011;65(5):270-8. doi: 10.1159/000326301. Epub 2011 Apr 8.

pubmed_id:21474939

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reference_text:Linnebank M, Popp J, Smulders Y, Smith D, Semmler A, Farkas M, Kulic L, Cvetanovska G, Blom H, Stoffel-Wagner B, Kolsch H, Weller M, Jessen F: S-adenosylmethionine is decreased in the cerebrospinal fluid of patients with Alzheimer's disease. Neurodegener Dis. 2010;7(6):373-8. doi: 10.1159/000309657. Epub 2010 Jun 3.

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reference_text:Rosler N, Wichart I, Jellinger KA: Clinical significance of neurobiochemical profiles in the lumbar cerebrospinal fluid of Alzheimer's disease patients. J Neural Transm (Vienna). 2001;108(2):231-46.

pubmed_id:11314776

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reference_text:Sunderland T, Berrettini WH, Molchan SE, Lawlor BA, Martinez RA, Vitiello B, Tariot PN, Cohen RM: Reduced cerebrospinal fluid dynorphin A1-8 in Alzheimer's disease. Biol Psychiatry. 1991 Jul 1;30(1):81-7.

pubmed_id:1716470

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reference_text:Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6.

pubmed_id:23857558

name:Heart failure

omim_id:

[1]:

reference_text:Norrelund H, Wiggers H, Halbirk M, Frystyk J, Flyvbjerg A, Botker HE, Schmitz O, Jorgensen JO, Christiansen JS, Moller N: Abnormalities of whole body protein turnover, muscle metabolism and levels of metabolic hormones in patients with chronic heart failure. J Intern Med. 2006 Jul;260(1):11-21.

pubmed_id:16789974

[2]:

reference_text:Ferreira A, Bettencourt P, Pestana M, Correia F, Serrao P, Martins L, Cerqueira-Gomes M, Soares-Da-Silva P: Heart failure, aging, and renal synthesis of dopamine. Am J Kidney Dis. 2001 Sep;38(3):502-9.

pubmed_id:11532681

[3]:

reference_text:Adams KF Jr, Gheorghiade M, Uretsky BF, Patterson JH, Schwartz TA, Young JB: Clinical benefits of low serum digoxin concentrations in heart failure. J Am Coll Cardiol. 2002 Mar 20;39(6):946-53.

pubmed_id:11897434

[4]:

reference_text:Bhagavan HN, Chopra RK: Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion. 2007 Jun;7 Suppl:S78-88. Epub 2007 Mar 27.

pubmed_id:17482886

[5]:

reference_text:Kang SM, Park JC, Shin MJ, Lee H, Oh J, Ryu DH, Hwang GS, Chung JH: (1)H nuclear magnetic resonance based metabolic urinary profiling of patients with ischemic heart failure. Clin Biochem. 2011 Mar;44(4):293-9. doi: 10.1016/j.clinbiochem.2010.11.010. Epub 2010 Dec 15.

pubmed_id:21167146

name:Schizophrenia

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21:

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pubmed_id:24130822

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pubmed_id:28842642

24:

name:Perillyl alcohol administration for cancer treatment

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26:

name:Periodontal disease

omim_id:170650

[1]:

pubmed_id:20300169

27:

name:Frontotemporal dementia

omim_id:600274

[1]:

pubmed_id:23857558

28:

name:Lewy body disease

omim_id:

[1]:

pubmed_id:23857558

29:

name:Autosomal dominant polycystic kidney disease

omim_id:601313

[1]:

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pubmed_id:18215696

[2]:

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pubmed_id:21389975

30:

name:Eosinophilic esophagitis

omim_id:610247

[1]:

reference_text:Mordechai, Hien, and David S. Wishart

pubmed_id:

KEGG数据库编号

C00065

DrugBank数据库编号

DB00133

foodb数据库编号

FDB012739

ChemSpider数据库编号

5736

公共化学化合物编号

5951

PDB数据库编号

生物利益的化学实体数据库编号

17115

knapsack数据库编号

C00001393

维基百科编号

L-serine

代谢途径的数据库编号

SER

苯酚资源管理器化合物数据库编号

比格数据库编号

33717

梅林编号

5203

虚拟机身份证编号

SER_L

fbonto数据库编号

综合参考

Qin, Wei-min; Cao, Fei; Zhou, Hua; Li, Zhen-jiang; Wei, Ping. Asymmetric synthesis of D- and L-serine with "Glycine equivalent" method. Huaxue Shiji (2005), 27(11), 643-644, 670.

一般参考

protein_accession:HMDBP00629

name:Serine--tRNA ligase, mitochondrial

uniprot_id:Q9NP81

gene_name:SARS2

protein_type:Enzyme

protein_accession:HMDBP00646

name:Serine--tRNA ligase, cytoplasmic

uniprot_id:P49591

gene_name:SARS

protein_type:Enzyme

protein_accession:HMDBP00671

name:L-serine dehydratase/L-threonine deaminase

uniprot_id:P20132

gene_name:SDS

protein_type:Enzyme

protein_accession:HMDBP00779

name:Cystathionine beta-synthase

uniprot_id:P35520

gene_name:CBS

protein_type:Unknown

protein_accession:HMDBP00789

name:Serine--pyruvate aminotransferase

uniprot_id:P21549

gene_name:AGXT

protein_type:Unknown

protein_accession:HMDBP00792

name:Serine hydroxymethyltransferase, mitochondrial

uniprot_id:P34897

gene_name:SHMT2

protein_type:Enzyme

protein_accession:HMDBP00794

name:Serine hydroxymethyltransferase, cytosolic

uniprot_id:P34896

gene_name:SHMT1

protein_type:Enzyme

protein_accession:HMDBP00886

name:Serine palmitoyltransferase 1

uniprot_id:O15269

gene_name:SPTLC1

protein_type:Enzyme

protein_accession:HMDBP00887

name:Phosphoserine phosphatase

uniprot_id:P78330

gene_name:PSPH

protein_type:Unknown

10:

protein_accession:HMDBP00888

name:Serine palmitoyltransferase 2

uniprot_id:O15270

gene_name:SPTLC2

protein_type:Enzyme

11:

protein_accession:HMDBP02190

name:Phosphatidylserine synthase 1

uniprot_id:P48651

gene_name:PTDSS1

protein_type:Enzyme

12:

protein_accession:HMDBP02960

name:Phosphatidylserine synthase 2

uniprot_id:Q9BVG9

gene_name:PTDSS2

protein_type:Enzyme

13:

protein_accession:HMDBP03110

name:Neutral amino acid transporter A

uniprot_id:P43007

gene_name:SLC1A4

protein_type:Unknown

14:

protein_accession:HMDBP05340

name:Monocarboxylate transporter 10

uniprot_id:Q8TF71

gene_name:SLC16A10

protein_type:Transporter

15:

protein_accession:HMDBP08972

name:Serine dehydratase-like

uniprot_id:Q96GA7

gene_name:SDSL

protein_type:Enzyme

16:

protein_accession:HMDBP08974

name:Serine palmitoyltransferase 3

uniprot_id:Q9NUV7

gene_name:SPTLC3

protein_type:Enzyme

17:

protein_accession:HMDBP08975

name:Serine racemase

uniprot_id:Q9GZT4

gene_name:SRR

protein_type:Enzyme

18:

protein_accession:HMDBP08981

name:Serine hydroxymethyltransferase

uniprot_id:A8MYA6

gene_name:SHMT1

protein_type:Enzyme

19:

protein_accession:HMDBP08988

name:Serine hydroxymethyltransferase

uniprot_id:Q5BJF5

gene_name:SHMT2

protein_type:Enzyme

20:

protein_accession:HMDBP10743

name:Serine incorporator 1

uniprot_id:Q9NRX5

gene_name:SERINC1

protein_type:Unknown

蛋白质结合

reference_text:Kaumeyer JF, Polazzi JO, Kotick MP: The mRNA for a proteinase inhibitor related to the HI-30 domain of inter-alpha-trypsin inhibitor also encodes alpha-1-microglobulin (protein HC). Nucleic Acids Res. 1986 Oct 24;14(20):7839-50.

pubmed_id:2430261

reference_text:Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762.

pubmed_id:19212411

reference_text:Nicholson JK, O'Flynn MP, Sadler PJ, Macleod AF, Juul SM, Sonksen PH: Proton-nuclear-magnetic-resonance studies of serum, plasma and urine from fasting normal and diabetic subjects. Biochem J. 1984 Jan 15;217(2):365-75.

pubmed_id:6696735

reference_text:Engelborghs S, Marescau B, De Deyn PP: Amino acids and biogenic amines in cerebrospinal fluid of patients with Parkinson's disease. Neurochem Res. 2003 Aug;28(8):1145-50.

pubmed_id:12834252

reference_text:Hagenfeldt L, Bjerkenstedt L, Edman G, Sedvall G, Wiesel FA: Amino acids in plasma and CSF and monoamine metabolites in CSF: interrelationship in healthy subjects. J Neurochem. 1984 Mar;42(3):833-7.

pubmed_id:6198473

pubmed_id:15911239

reference_text:Cynober LA: Plasma amino acid levels with a note on membrane transport: characteristics, regulation, and metabolic significance. Nutrition. 2002 Sep;18(9):761-6.

pubmed_id:12297216

reference_text:Rainesalo S, Keranen T, Palmio J, Peltola J, Oja SS, Saransaari P: Plasma and cerebrospinal fluid amino acids in epileptic patients. Neurochem Res. 2004 Jan;29(1):319-24.

pubmed_id:14992292

reference_text:Fontaine M, Porchet N, Largilliere C, Marrakchi S, Lhermitte M, Aubert JP, Degand P: Biochemical contribution to diagnosis and study of a new case of D-glyceric acidemia/aciduria. Clin Chem. 1989 Oct;35(10):2148-51.

pubmed_id:2551543

10:

reference_text:Furuya S, Watanabe M: Novel neuroglial and glioglial relationships mediated by L-serine metabolism. Arch Histol Cytol. 2003 May;66(2):109-21.

pubmed_id:12846552

11:

reference_text:Haas W, Grabe K, Geis C, Pach T, Stoll K, Fuchs M, Haberl B, Loy C: Recognition and invasion of human skin by Schistosoma mansoni cercariae: the key-role of L-arginine. Parasitology. 2002 Feb;124(Pt 2):153-67.

pubmed_id:11860033

12:

reference_text:Hashimoto K, Engberg G, Shimizu E, Nordin C, Lindstrom LH, Iyo M: Reduced D-serine to total serine ratio in the cerebrospinal fluid of drug naive schizophrenic patients. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jun;29(5):767-9.

pubmed_id:15939521

13:

reference_text:Castedo M, Ferri KF, Blanco J, Roumier T, Larochette N, Barretina J, Amendola A, Nardacci R, Metivier D, Este JA, Piacentini M, Kroemer G: Human immunodeficiency virus 1 envelope glycoprotein complex-induced apoptosis involves mammalian target of rapamycin/FKBP12-rapamycin-associated protein-mediated p53 phosphorylation. J Exp Med. 2001 Oct 15;194(8):1097-110.

pubmed_id:11602639

14:

reference_text:Liu T, Zhu E, Wang L, Okada T, Yamaguchi A, Okada N: Abnormal expression of Rb pathway-related proteins in salivary gland acinic cell carcinoma. Hum Pathol. 2005 Sep;36(9):962-70.

pubmed_id:16153458

15:

reference_text:Franchi-Gazzola R, Gazzola GC, Dall'Asta V, Guidotti GG: The transport of alanine, serine, and cysteine in cultured human fibroblasts. J Biol Chem. 1982 Aug 25;257(16):9582-7.

pubmed_id:6809740

16:

reference_text:Yamamoto T, Nishizaki I, Nukada T, Kamegaya E, Furuya S, Hirabayashi Y, Ikeda K, Hata H, Kobayashi H, Sora I, Yamamoto H: Functional identification of ASCT1 neutral amino acid transporter as the predominant system for the uptake of L-serine in rat neurons in primary culture. Neurosci Res. 2004 May;49(1):101-11.

pubmed_id:15099708

17:

reference_text:Mackie S, Aitken A: Novel brain 14-3-3 interacting proteins involved in neurodegenerative disease. FEBS J. 2005 Aug;272(16):4202-10.

pubmed_id:16098201

18:

reference_text:Kobza K, Camporeale G, Rueckert B, Kueh A, Griffin JB, Sarath G, Zempleni J: K4, K9 and K18 in human histone H3 are targets for biotinylation by biotinidase. FEBS J. 2005 Aug;272(16):4249-59.

pubmed_id:16098205

19:

reference_text:Whittemore AS, Cirillo PM, Feldman D, Cohn BA: Prostate specific antigen levels in young adulthood predict prostate cancer risk: results from a cohort of Black and White Americans. J Urol. 2005 Sep;174(3):872-6; discussion 876.

pubmed_id:16093978

20:

reference_text:Schulz I, Zeitschel U, Rudolph T, Ruiz-Carrillo D, Rahfeld JU, Gerhartz B, Bigl V, Demuth HU, Rossner S: Subcellular localization suggests novel functions for prolyl endopeptidase in protein secretion. J Neurochem. 2005 Aug;94(4):970-9.

pubmed_id:16092940

21:

reference_text:de Koning TJ, Snell K, Duran M, Berger R, Poll-The BT, Surtees R: L-serine in disease and development. Biochem J. 2003 May 1;371(Pt 3):653-61.

pubmed_id:12534373

22:

reference_text:Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043.

pubmed_id:32033212

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