版本
5.0
创建日期
2005-11-16 15:48:42 UTC
更新日期
2021-09-14 15:46:58 UTC
登录号
HMDB0000182
地位
quantified
二级访问
HMDB00182

HMDB0062809

HMDB62809

名称
L-Lysine
描述
Lysine (Lys), also known as L-lysine is an alpha-amino acid. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). Amino acids are organic compounds that contain amino (–NH2) and carboxyl (–COOH) functional groups, along with a side chain (R group) specific to each amino acid. Lysine is one of 20 proteinogenic amino acids, i.e., the amino acids used in the biosynthesis of proteins. Lysine is found in all organisms ranging from bacteria to plants to animals. It is classified as an aliphatic, positively charged or basic amino acid. In humans, lysine is an essential amino acid, meaning the body cannot synthesize it, and it must be obtained from the diet. Lysine is high in foods such as wheat germ, cottage cheese and chicken. Of meat products, wild game and pork have the highest concentration of lysine. Fruits and vegetables contain little lysine, except avocados. Normal requirements for lysine have been found to be about 8 g per day or 12 mg/kg in adults. Children and infants need more, 44 mg/kg per day for an eleven to-twelve-year old, and 97 mg/kg per day for three-to six-month old. In organisms that synthesise lysine, it has two main biosynthetic pathways, the diaminopimelate and α-aminoadipate pathways, which employ distinct enzymes and substrates and are found in diverse organisms. Lysine catabolism occurs through one of several pathways, the most common of which is the saccharopine pathway. Lysine plays several roles in humans, most importantly proteinogenesis, but also in the crosslinking of collagen polypeptides, uptake of essential mineral nutrients, and in the production of carnitine, which is key in fatty acid metabolism. Lysine is also often involved in histone modifications, and thus, impacts the epigenome. Lysine is highly concentrated in muscle compared to most other amino acids. Normal lysine metabolism is dependent upon many nutrients including niacin, vitamin B6, riboflavin, vitamin C, glutamic acid and iron. Excess arginine antagonizes lysine. Several inborn errors of lysine metabolism are known, such as cystinuria, hyperdibasic aminoaciduria I, lysinuric protein intolerance, propionic acidemia, and tyrosinemia I. Most are marked by mental retardation with occasional diverse symptoms such as absence of secondary sex characteristics, undescended testes, abnormal facial structure, anemia, obesity, enlarged liver and spleen, and eye muscle imbalance. Lysine also may be a useful adjunct in the treatment of osteoporosis. Although high protein diets result in loss of large amounts of calcium in urine, so does lysine deficiency. Lysine may be an adjunct therapy because it reduces calcium losses in urine. Lysine deficiency also may result in immunodeficiency. Requirements for lysine are probably increased by stress. Lysine toxicity has not occurred with oral doses in humans. Lysine dosages are presently too small and may fail to reach the concentrations necessary to prove potential therapeutic applications. Lysine metabolites, amino caproic acid and carnitine have already shown their therapeutic potential. Thirty grams daily of amino caproic acid has been used as an initial daily dose in treating blood clotting disorders, indicating that the proper doses of lysine, its precursor, have yet to be used in medicine. Low lysine levels have been found in patients with Parkinson's, hypothyroidism, kidney disease, asthma and depression. The exact significance of these levels is unclear, yet lysine therapy can normalize the level and has been associated with improvement of some patients with these conditions. Abnormally elevated hydroxylysines have been found in virtually all chronic degenerative diseases and those treated with coumadin therapy. The levels of this stress marker may be improved by high doses of vitamin C. Lysine is particularly useful in therapy for marasmus (wasting) (http://www.dcnutrition.com). Lysine has also been shown to play a role in anaemia, as lysine is suspected to have an effect on the uptake of iron and, subsequently, the concentration of ferritin in blood plasma.
同义词
1:(S)-2,6-Diaminohexanoic acid

2:(S)-alpha,epsilon-Diaminocaproic acid

3:(S)-Lysine

4:6-Ammonio-L-norleucine

5:K

6:L-2,6-Diaminocaproic acid

7:L-Lysin

8:Lys

9:Lysina

10:Lysine

11:Lysine acid

12:Lysinum

13:2,6-Diaminohexanoic acid

14:(S)-2,6-Diaminohexanoate

15:(S)-a,epsilon-Diaminocaproate

16:(S)-a,epsilon-Diaminocaproic acid

17:(S)-alpha,epsilon-Diaminocaproate

18:(S)-Α,epsilon-diaminocaproate

19:(S)-Α,epsilon-diaminocaproic acid

20:L-2,6-Diaminocaproate

21:2,6-Diaminohexanoate

22:(+)-S-Lysine

23:(S)-2,6-Diamino-hexanoate

24:(S)-2,6-Diamino-hexanoic acid

25:(S)-a,e-Diaminocaproate

26:(S)-a,e-Diaminocaproic acid

27:6-Amino-aminutrin

28:6-Amino-L-norleucine

29:a-Lysine

30:alpha-Lysine

31:Aminutrin

32:H-Lys-OH

33:L-(+)-Lysine

34:L-2,6-Diainohexanoate

35:L-2,6-Diainohexanoic acid

36:L-Lys

37:Acetate, lysine

38:Enisyl

39:Lysine hydrochloride

40:L Lysine

41:Lysine acetate

化学式
C6H14N2O2
平均分子量
146.1876
等位分子量
146.105527702
化学名称
(2S)-2,6-diaminohexanoic acid
传统名称
L-lysine
CAS 登记号
56-87-1
代谢物结构字符串
NCCCC[C@H](N)C(O)=O
inchi标识符
InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/t5-/m0/s1
印记键
KDXKERNSBIXSRK-YFKPBYRVSA-N
分类学
description: belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.

description:L-alpha-amino acids

kingdom:Organic compounds

super_class:Organic acids and derivatives

class:Carboxylic acids and derivatives

sub_class:Amino acids, peptides, and analogues

molecular_framework:Aliphatic acyclic compounds

1:Amino acids

2:Amino fatty acids

3:Carbonyl compounds

4:Carboxylic acids

5:Hydrocarbon derivatives

6:Medium-chain fatty acids

7:Monoalkylamines

8:Monocarboxylic acids and derivatives

9:Organic oxides

10:Organopnictogen compounds

11:Aliphatic acyclic compound

12:Amine

13:Amino acid

14:Amino fatty acid

15:Carbonyl group

16:Carboxylic acid

17:Fatty acid

18:Fatty acyl

19:Hydrocarbon derivative

20:L-alpha-amino acid

21:Medium-chain fatty acid

22:Monocarboxylic acid or derivatives

23:Organic nitrogen compound

24:Organic oxide

25:Organic oxygen compound

26:Organonitrogen compound

27:Organooxygen compound

28:Organopnictogen compound

29:Primary aliphatic amine

30:Primary amine

31:Common amino acids

32:L-alpha-amino acid

33:aspartate family amino acid

34:lysine

35:proteinogenic amino acid

本体论
term:Physiological effect

definition:The effect on an organism physiology, resulting from its exposure to a chemical.

parent_id:

level:1

type:parent

term:Health effect

definition:A health condition or observation associated with a stimuli or with a biological activity of a chemical.

parent_id:7693

*level:2

type:parent

term:Observation

definition:A short term health effect which reflects the reponse of the body to stimuli or is a symptom of a disease or condition; also includes health status which reflects stage in life.

parent_id:7694

**level:3

type:parent

term:Attachment loss

definition:

parent_id:7717

***level:4

type:child

term:Missing teeth

definition:

parent_id:7717

***level:4

type:child

term:Periodontal Probing Depth

definition:

parent_id:7717

***level:4

type:child

term:Supragingival Calculus

definition:

parent_id:7717

***level:4

type:child

term:Health condition

definition:A health effect that consists on short or long-term disease, condition, disorder, syndrome or constant abnormality.

parent_id:7694

**level:3

type:parent

term:Refractory localization-related epilepsy

definition:

parent_id:7695

***level:4

type:child

synonym:Rle

term:Schizophrenia

definition:A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness. (do).

parent_id:7695

***level:4

type:child

term:Hyperdibasic aminoaciduria i

definition:

parent_id:7695

***level:4

type:child

synonym:Dibasic aminoaciduria i

term:Cancer

definition:A group of disorders characterized by the presense of malignant neoplasm.

parent_id:7695

***level:4

type:parent

term:Disposition

definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.

parent_id:

level:1

type:parent

term:Route of exposure

definition:A mean by which a chemical agent comes in contact with an organism, either under intended or unintended circumstances.

parent_id:7724

*level:2

type:parent

term:Enteral

definition:Chemical exposure via the alimentary canal (mouth to anus).

parent_id:7743

**level:3

type:parent

term:Ingestion

definition:Chemical exposure facilitated by entry through the mouth.

parent_id:7744

***level:4

type:child

synonym:Digestion

term:Source

definition:Natural or synthetic origin of a chemical.

parent_id:7724

*level:2

type:parent

term:Food

definition:

parent_id:7735

**level:3

type:child

term:Synthetic

definition:A man-made product or sample in which a chemical can be found.

parent_id:7735

**level:3

type:parent

term:Personal care product

definition:

parent_id:7742

***level:4

type:child

synonym:Pcp

synonym:Toiletries

synonym:Toiletry

synonym:Personal hygiene

synonym:Beautification product

term:Biological

definition:A living organism (species or a higher taxonomy rank), in which a chemical can be found.

parent_id:7735

**level:3

type:parent

term:Animal

definition:A living organism belonging to the kingdom animalia. it feeds on organic matter, typically having specialized sense organs and nervous system and able to respond rapidly to stimuli.

parent_id:7736

***level:4

type:child

synonym:Fauna

term:Plant

definition:A living organism belonging to the kingdom plantea. typically, it grows in a permanent site, absorbs water and inorganic substances through its roots, and synthesizes nutrients in its leaves by photosynthesis using the green pigment chlorophyll. examples incude trees, shrubs, herbs, grasses, ferns, and mosses.

parent_id:7736

***level:4

type:parent

synonym:Flora

term:Biological location

definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.

parent_id:7724

*level:2

type:parent

term:Tissue and substructures

definition:An anatomical organizational level including multiple cells yet not comprising a complete organ .

parent_id:7725

**level:3

type:parent

term:All tissues

definition:All tissues in the body of the organism.

parent_id:7729

***level:4

type:child

term:Placenta

definition:An organ present in some vertebrates during embryonic gestation that surrounds the fetus and provides it with nutrients and oxygen, facilitates gas and waste exchange between the fetus and mother, and provides parasitic cloaking from the mother's immune system by excretion of neurokinin b. (nci).

parent_id:7729

***level:4

type:child

term:Organ and components

definition:An anatomical organizational level including multiple tissues or substructures, which enables a common biological function.

parent_id:7725

**level:3

type:parent

term:Prostate

definition:The male reproductive accessory gland that produces prostatic fluid and is located adjacent to or around the urethra distal to the urinary bladder in mammals. (nci).

parent_id:7727

***level:4

type:child

synonym:Prostate gland

term:Biofluid and excreta

definition:A liquid, semi-solid or solid material originating in the body.

parent_id:7725

**level:3

type:parent

term:Urine

definition:Excretion in liquid state processed by the kidney.

parent_id:7731

***level:4

type:child

term:Saliva

definition:The watery fluid in the mouth made by the salivary glands. saliva moistens food to help digestion and it helps protect the mouth against infections. (nci).

parent_id:7731

***level:4

type:child

term:Feces

definition:The material discharged from the bowel during defecation. It consists of undigested food, intestinal mucus, epithelial cells, and bacteria.

parent_id:7731

***level:4

type:child

synonym:Fecal

synonym:Stool

synonym:Faecal

synonym:Faeces

term:Blood

definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.

parent_id:7731

***level:4

type:child

term:Breast milk

definition:Portion of secreted substance produced by the mammary gland.

parent_id:7731

***level:4

type:child

term:Sweat

definition:Secretion produced by a sweat gland.

parent_id:7731

***level:4

type:child

term:Cerebrospinal fluid

definition:The fluid that is contained within the brain ventricles, the subarachnoid space and the central canal of the spinal cord. (nci).

parent_id:7731

***level:4

type:child

synonym:Csf

term:Subcellular

definition:An anatomical organizational level including a component within a biological cell .

parent_id:7725

**level:3

type:parent

term:Cytoplasm

definition:The portion of the cell contained within the plasma membrane but excluding the nucleus.

parent_id:7730

***level:4

type:child

synonym:Cytoplasma

term:Mitochondria

definition:

parent_id:7730

***level:4

type:child

term:Nucleus

definition:A body within the cell, surrounded by a membrane, within which lie the chromosomes, one or more nucleoli, combined with proteins, and exhibits mitosis. (NCI)

parent_id:7730

***level:4

type:child

synonym:Cell nucleus

synonym:Nucleic

term:Peroxisome

definition:A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. (Gene Ontology).

parent_id:7730

***level:4

type:child

synonym:Peroxisome vesicle

synonym:Peroxisomal

term:Cell and elements

definition:An anatomical organizational level comprising of a single cell (or a fragment in some exceptions). a cell is defined by its type or function. it is the smallest unit of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid.

parent_id:7725

**level:3

type:parent

term:Extracellular

definition:The space external to the outermost structure of a cell.

parent_id:7732

***level:4

type:child

synonym:Extracellular region

term:Process

definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.

parent_id:

level:1

type:parent

term:Naturally occurring process

definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.

parent_id:7659

*level:2

type:parent

term:Biological process

definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.

parent_id:7660

**level:3

type:parent

term:Biochemical pathway

definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.

parent_id:7661

***level:4

type:parent

term:Role

definition:The purpose or function assumed by a chemical, either naturally or as intended by humans .

parent_id:

level:1

type:parent

term:Industrial application

definition:The assumed function of a chemical utilized by human.

parent_id:7671

*level:2

type:parent

term:Drug

definition:A chemical substance or preparation that causes a physiological effect in the body upon exposure .

parent_id:7678

**level:3

type:child

term:Personal care products

definition:Cosmetics and personal hygene products in which a chemical was incorportaed during the manufacturing process.

parent_id:7678

**level:3

type:child

term:Food and nutrition

definition:A chemical purpose related to manufacturing of food and nutrition products.

parent_id:7678

**level:3

type:parent

term:Nutritional supplement

definition:

parent_id:7687

***level:4

type:child

synonym:Nutraceutical

synonym:Dietary supplement

term:Pharmaceutical industry

definition:A pharmacologic activity for which a chemical substance is utilized owing to its biological role.

parent_id:7678

**level:3

type:parent

term:Anticonvulsant

definition:

parent_id:7679

***level:4

type:child

synonym:Anti convulsant

synonym:Anti-convulsant

term:Biological role

definition:The biological function of a chemical. the biological role answers the question how a chemical is involved in molecular processes in an organism. this can include biochemical effects of non-endogenous chemicals, which are also assigned an industrial application such as pharmaceuticals. the biological role is limited to cellular levls, and will not include role at system process level, such as a chemical which has a role in a disease.

parent_id:7671

*level:2

type:parent

term:Essential amino acid

definition:

parent_id:7672

**level:3

type:child

term:Trace element

definition:A chemical element that occurs in very small amounts in organisms and is essential for many physiological and biochemical processes.В .

parent_id:7672

**level:3

type:child

synonym:Trace mineral

synonym:Essential mineral

状态
Solid
实验性质
1:

kind:water_solubility

value:1000.0 mg/mL

source:

2:

kind:logp

value:-3.05

source:HANSCH,C ET AL. (1995)

3:

kind:melting_point

value:224.5 °C

source:

预测性质
1:

kind:logp

value:-3.76

source:ALOGPS

2:

kind:logs

value:-0.14

source:ALOGPS

3:

kind:solubility

value:105 g/L

source:ALOGPS

4:

kind:logp

value:-3.2

source:ChemAxon

5:

kind:pka_strongest_acidic

value:2.74

source:ChemAxon

6:

kind:pka_strongest_basic

value:10.29

source:ChemAxon

7:

kind:iupac

value:(2S)-2,6-diaminohexanoic acid

source:ChemAxon

8:

kind:average_mass

value:146.1876

source:ChemAxon

9:

kind:mono_mass

value:146.105527702

source:ChemAxon

10:

kind:smiles

value:NCCCC[C@H](N)C(O)=O

source:ChemAxon

11:

kind:formula

value:C6H14N2O2

source:ChemAxon

12:

kind:inchi

value:InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/t5-/m0/s1

source:ChemAxon

13:

kind:inchikey

value:KDXKERNSBIXSRK-YFKPBYRVSA-N

source:ChemAxon

14:

kind:polar_surface_area

value:89.34

source:ChemAxon

15:

kind:refractivity

value:37.81

source:ChemAxon

16:

kind:polarizability

value:15.84

source:ChemAxon

17:

kind:rotatable_bond_count

value:5

source:ChemAxon

18:

kind:acceptor_count

value:4

source:ChemAxon

19:

kind:donor_count

value:3

source:ChemAxon

20:

kind:physiological_charge

value:1

source:ChemAxon

21:

kind:formal_charge

value:0

source:ChemAxon

22:

kind:number_of_rings

value:0

source:ChemAxon

23:

kind:bioavailability

value:Yes

source:ChemAxon

24:

kind:rule_of_five

value:Yes

source:ChemAxon

25:

kind:ghose_filter

value:No

source:ChemAxon

26:

kind:veber_rule

value:No

source:ChemAxon

27:

kind:mddr_like_rule

value:No

source:ChemAxon

1:

type:Specdb::NmrOneD

spectrum_id:1151

2:

type:Specdb::NmrOneD

spectrum_id:1194

3:

type:Specdb::NmrOneD

spectrum_id:4846

4:

type:Specdb::NmrOneD

spectrum_id:142750

5:

type:Specdb::NmrOneD

spectrum_id:142751

6:

type:Specdb::NmrOneD

spectrum_id:142752

7:

type:Specdb::NmrOneD

spectrum_id:142753

8:

type:Specdb::NmrOneD

spectrum_id:142754

9:

type:Specdb::NmrOneD

spectrum_id:142755

10:

type:Specdb::NmrOneD

spectrum_id:142756

11:

type:Specdb::NmrOneD

spectrum_id:142757

12:

type:Specdb::NmrOneD

spectrum_id:142758

13:

type:Specdb::NmrOneD

spectrum_id:142759

14:

type:Specdb::NmrOneD

spectrum_id:142760

15:

type:Specdb::NmrOneD

spectrum_id:142761

16:

type:Specdb::NmrOneD

spectrum_id:142762

17:

type:Specdb::NmrOneD

spectrum_id:142763

18:

type:Specdb::NmrOneD

spectrum_id:142764

19:

type:Specdb::NmrOneD

spectrum_id:142765

20:

type:Specdb::NmrOneD

spectrum_id:142766

21:

type:Specdb::NmrOneD

spectrum_id:142767

22:

type:Specdb::NmrOneD

spectrum_id:142768

23:

type:Specdb::NmrOneD

spectrum_id:142769

24:

type:Specdb::NmrOneD

spectrum_id:166351

25:

type:Specdb::NmrOneD

spectrum_id:166447

26:

type:Specdb::NmrTwoD

spectrum_id:985

27:

type:Specdb::NmrTwoD

spectrum_id:1191

28:

type:Specdb::CMs

spectrum_id:423

29:

type:Specdb::CMs

spectrum_id:424

30:

type:Specdb::CMs

spectrum_id:425

31:

type:Specdb::CMs

spectrum_id:1365

32:

type:Specdb::CMs

spectrum_id:1547

33:

type:Specdb::CMs

spectrum_id:1644

34:

type:Specdb::CMs

spectrum_id:2495

35:

type:Specdb::CMs

spectrum_id:30111

36:

type:Specdb::CMs

spectrum_id:30112

37:

type:Specdb::CMs

spectrum_id:30377

38:

type:Specdb::CMs

spectrum_id:30602

39:

type:Specdb::CMs

spectrum_id:30737

40:

type:Specdb::CMs

spectrum_id:30794

41:

type:Specdb::CMs

spectrum_id:31054

42:

type:Specdb::CMs

spectrum_id:31055

43:

type:Specdb::CMs

spectrum_id:31056

44:

type:Specdb::CMs

spectrum_id:32353

45:

type:Specdb::CMs

spectrum_id:37342

46:

type:Specdb::CMs

spectrum_id:148423

47:

type:Specdb::MsMs

spectrum_id:3416

48:

type:Specdb::MsMs

spectrum_id:3417

49:

type:Specdb::MsMs

spectrum_id:3418

50:

type:Specdb::MsMs

spectrum_id:3419

51:

type:Specdb::MsMs

spectrum_id:3420

52:

type:Specdb::MsMs

spectrum_id:3432

53:

type:Specdb::MsMs

spectrum_id:438021

54:

type:Specdb::MsMs

spectrum_id:438022

55:

type:Specdb::MsMs

spectrum_id:438023

56:

type:Specdb::MsMs

spectrum_id:438024

57:

type:Specdb::MsMs

spectrum_id:438025

58:

type:Specdb::MsMs

spectrum_id:439196

59:

type:Specdb::MsMs

spectrum_id:2226976

60:

type:Specdb::MsMs

spectrum_id:2231764

61:

type:Specdb::MsMs

spectrum_id:2231775

62:

type:Specdb::MsMs

spectrum_id:2232412

63:

type:Specdb::MsMs

spectrum_id:2232446

64:

type:Specdb::MsMs

spectrum_id:2234160

65:

type:Specdb::MsMs

spectrum_id:2234762

66:

type:Specdb::MsMs

spectrum_id:2252966

67:

type:Specdb::MsMs

spectrum_id:2253523

68:

type:Specdb::MsMs

spectrum_id:289

69:

type:Specdb::MsMs

spectrum_id:290

70:

type:Specdb::MsMs

spectrum_id:291

71:

type:Specdb::MsMs

spectrum_id:3408

光谱
生物学性质
1:

cellular:(1):Cytoplasm

cellular:(2):Extracellular

cellular:(3):Mitochondria

cellular:(4):Nucleus

cellular:(5):Peroxisome

2:

biospecimen:(1):Blood

biospecimen:(2):Breast Milk

biospecimen:(3):Cerebrospinal Fluid (CSF)

biospecimen:(4):Feces

biospecimen:(5):Saliva

biospecimen:(6):Sweat

biospecimen:(7):Urine

3:

tissue:(1):All Tissues

tissue:(2):Placenta

tissue:(3):Prostate

4:

[1]:

name:2-aminoadipic 2-oxoadipic aciduria

smpdb_id:SMP00719

kegg_map_id:

[2]:

name:Biotin Metabolism

smpdb_id:SMP00066

kegg_map_id:map00780

[3]:

name:Biotinidase Deficiency

smpdb_id:SMP00174

kegg_map_id:

[4]:

name:Carnitine Synthesis

smpdb_id:SMP00465

kegg_map_id:

[5]:

name:Glutaric Aciduria Type I

smpdb_id:SMP00186

kegg_map_id:

[6]:

name:Hyperlysinemia I, Familial

smpdb_id:SMP00527

kegg_map_id:

[7]:

name:Hyperlysinemia II or Saccharopinuria

smpdb_id:SMP00528

kegg_map_id:

[8]:

name:Lysine degradation

smpdb_id:

kegg_map_id:map00310

[9]:

name:Multiple carboxylase deficiency, neonatal or early onset form

smpdb_id:SMP00564

kegg_map_id:

[10]:

name:Pyridoxine dependency with seizures

smpdb_id:SMP00571

kegg_map_id:

[11]:

name:Saccharopinuria/Hyperlysinemia II

smpdb_id:SMP00239

kegg_map_id:

[12]:

name:Transcription/Translation

smpdb_id:SMP00019

kegg_map_id:

正常浓度
1:

biospecimen:Blood

concentration_value:190.0 +/- 60.0

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Not Specified

subject_condition:Normal

2:

biospecimen:Blood

concentration_value:164.0 +/- 28.0

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Female

subject_condition:Normal

3:

biospecimen:Blood

concentration_value:198.0 +/- 31.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

4:

biospecimen:Blood

concentration_value:183.0 +/- 34.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

5:

biospecimen:Blood

concentration_value:71-151

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

6:

biospecimen:Blood

concentration_value:113-269

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

7:

biospecimen:Blood

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

8:

biospecimen:Blood

concentration_value:441 (384-516)

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:

subject_condition:Normal

9:

biospecimen:Blood

concentration_value:120-203

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Not Specified

subject_condition:Normal

10:

biospecimen:Blood

concentration_value:112-231

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Both

subject_condition:Normal

11:

biospecimen:Blood

concentration_value:85-241

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

12:

biospecimen:Blood

concentration_value:189 +/- 27

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

13:

biospecimen:Blood

concentration_value:238 (192-295)

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:

subject_condition:Normal

14:

biospecimen:Blood

concentration_value:161 +/- 21

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

15:

biospecimen:Blood

concentration_value:105.100 +/- 30.100

concentration_units:uM

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

16:

biospecimen:Blood

concentration_value:434.0 +/- 23.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

17:

biospecimen:Blood

concentration_value:110.0-240.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

18:

biospecimen:Blood

concentration_value:197.4 +/- 30.7

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

19:

biospecimen:Blood

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

20:

biospecimen:Blood

concentration_value:197 (184-216)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

21:

biospecimen:Blood

concentration_value:56-256

concentration_units:uM

subject_age:Children (1 - 13 years old)

subject_sex:Both

subject_condition:Normal

22:

biospecimen:Blood

concentration_value:82 - 224

concentration_units:uM

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

23:

biospecimen:Blood

concentration_value:92-325

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

24:

biospecimen:Blood

concentration_value:40-163

concentration_units:uM

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

25:

biospecimen:Blood

concentration_value:127.8(108.8-147.7)

concentration_units:uM

subject_age:Children (1-13 uears old)

subject_sex:Both

subject_condition:Normal

26:

biospecimen:Blood

concentration_value:71-272

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

27:

biospecimen:Blood

concentration_value:37-228

concentration_units:uM

subject_age:Infant (1 - 3 months old)

subject_sex:Both

subject_condition:Normal

28:

biospecimen:Blood

concentration_value:85-250

concentration_units:uM

subject_age:Children (3 months - 6 years old)

subject_sex:Both

subject_condition:Normal

29:

biospecimen:Blood

concentration_value:108-270

concentration_units:uM

subject_age:Children (6 - 18 years old)

subject_sex:Both

subject_condition:Normal

30:

biospecimen:Blood

concentration_value:178.6 +/- 58.2

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

31:

biospecimen:Blood

concentration_value:188.0 (156.0-220.0)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

32:

biospecimen:Breast Milk

concentration_value:11.1 +/- 8.8

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

33:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:21.7 +/- 3.7

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

34:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:29.0 +/- 13.0

concentration_units:uM

subject_age:Not Specified

subject_sex:Both

subject_condition:Normal

35:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:10-28

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Both

subject_condition:Normal

36:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:14.100-25.300

concentration_units:uM

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

37:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:6-37

concentration_units:uM

subject_age:Children (0 - 10 years old)

subject_sex:Both

subject_condition:Normal

38:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:27.7 +/- 8.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

39:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:12-43

concentration_units:uM

subject_age:Adolescent (>11 years old)

subject_sex:Both

subject_condition:Normal

40:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:31.5 +/- 5.7

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

41:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:25.7 +/- 5.3

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

42:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:23.9 (18.1-29.7)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

43:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

44:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

45:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

46:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

47:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Children (1-13 years old)

subject_sex:Both

subject_condition:Normal

48:

biospecimen:Feces

concentration_value:3078.236 (2052.158-4104.315)

concentration_units:nmol/g wet feces

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

49:

biospecimen:Feces

concentration_value:4697.161 (1983.752-7410.569)

concentration_units:nmol/g wet feces

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

50:

biospecimen:Feces

concentration_value:2964.228 (1664.528-4263.928)

concentration_units:nmol/g wet feces

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

51:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

52:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Not Specified

subject_sex:Both

subject_condition:Normal

53:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

54:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

55:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

56:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

57:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

58:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Children (6 - 18 years old)

subject_sex:Not Specified

subject_condition:Normal

59:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

60:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

61:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

62:

biospecimen:Feces

concentration_value:540 +/- 410

concentration_units:nmol/g wet feces

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

63:

biospecimen:Feces

concentration_value:40 +/- 30

concentration_units:nmol/g wet feces

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

64:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

65:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

66:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

67:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

68:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

69:

biospecimen:Saliva

concentration_value:59.20 +/- 46.76

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

70:

biospecimen:Saliva

concentration_value:45.1 +/- 45.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

71:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

72:

biospecimen:Saliva

concentration_value:19.2 +/- 12.8

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

73:

biospecimen:Saliva

concentration_value:9.8 +/- 5.2

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

74:

biospecimen:Saliva

concentration_value:9.2 +/- 4.1

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

75:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

76:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

77:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

78:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

79:

biospecimen:Saliva

concentration_value:2.2 +/- 3.8

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

80:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

81:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

82:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

83:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

84:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

85:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

86:

biospecimen:Saliva

concentration_value:37.76 +/- 18.10

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

87:

biospecimen:Saliva

concentration_value:3.7 +/- 6.3

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

88:

biospecimen:Saliva

concentration_value:>10

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

89:

biospecimen:Sweat

concentration_value:< 10

concentration_units:uM

subject_age:Adult (60 years old)

subject_sex:Male

subject_condition:Normal

90:

biospecimen:Sweat

concentration_value:< 10

concentration_units:uM

subject_age:Adult (40 years old)

subject_sex:Male

subject_condition:Normal

91:

biospecimen:Sweat

concentration_value:

concentration_units:

subject_age:Adult

subject_sex:Both

subject_condition:Normal

92:

biospecimen:Urine

concentration_value:31.45 +/- 52.32

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

93:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

94:

biospecimen:Urine

concentration_value:10.5-140.5

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

95:

biospecimen:Urine

concentration_value:38.05 +/- 15.47

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Female

subject_condition:Normal

96:

biospecimen:Urine

concentration_value:51.37 +/- 33.33

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Male

subject_condition:Normal

97:

biospecimen:Urine

concentration_value:1.92-31.22

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

98:

biospecimen:Urine

concentration_value:23.654 +/- 19.414

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

99:

biospecimen:Urine

concentration_value:1.13-27.15

concentration_units:umol/mmol creatinine

subject_age:Adolescent (13-18 years old)

subject_sex:Not Specified

subject_condition:Normal

100:

biospecimen:Urine

concentration_value:3.42-75.29

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

101:

biospecimen:Urine

concentration_value:5.2-16

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

102:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

103:

biospecimen:Urine

concentration_value:18.09 - 217.98

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

104:

biospecimen:Urine

concentration_value:8.71 - 199.10

concentration_units:umol/mmol creatinine

subject_age:Infant (1 - 6 months old)

subject_sex:Both

subject_condition:Normal

105:

biospecimen:Urine

concentration_value:5.99 - 94.63

concentration_units:umol/mmol creatinine

subject_age:Infant (6 months - <1 year old)

subject_sex:Both

subject_condition:Normal

106:

biospecimen:Urine

concentration_value:10.06 - 81.18

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 2 years old)

subject_sex:Both

subject_condition:Normal

107:

biospecimen:Urine

concentration_value:1.92 - 50.31

concentration_units:umol/mmol creatinine

subject_age:Children (2 - 4 years old)

subject_sex:Both

subject_condition:Normal

108:

biospecimen:Urine

concentration_value:1.92 - 79.82

concentration_units:umol/mmol creatinine

subject_age:Children (4 - 13 years old)

subject_sex:Both

subject_condition:Normal

109:

biospecimen:Urine

concentration_value:0 - 66.37

concentration_units:umol/mmol creatinine

subject_age:Adolescent (13 - 21 years old)

subject_sex:Both

subject_condition:Normal

110:

biospecimen:Urine

concentration_value:0 - 66.37

concentration_units:umol/mmol creatinine

subject_age:Adult (>21 years old)

subject_sex:Both

subject_condition:Normal

111:

biospecimen:Urine

concentration_value:1.70-30.65

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

112:

biospecimen:Urine

concentration_value:10.9(2.105-19.7)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

113:

biospecimen:Urine

concentration_value:29.867 +/- 22.0667

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

114:

biospecimen:Urine

concentration_value:7.467 +/- 6.360

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 13 years old)

subject_sex:Female

subject_condition:Normal

115:

biospecimen:Urine

concentration_value:17.2 (3.7-51.3)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

116:

biospecimen:Urine

concentration_value:1.32-26.75

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Male

subject_condition:Normal

117:

biospecimen:Urine

concentration_value:32.800 +/- 27.667

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

118:

biospecimen:Urine

concentration_value:7.70-30.13

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Female

subject_condition:Normal

119:

biospecimen:Urine

concentration_value:10.87 +/- 8.80

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Male

subject_condition:Normal

120:

biospecimen:Urine

concentration_value:13.09 +/- 5.90

concentration_units:umol/mmol creatinine

subject_age:Children (0-2 years old)

subject_sex:Male

subject_condition:Normal

121:

biospecimen:Urine

concentration_value:13.44 +/- 5.50

concentration_units:umol/mmol creatinine

subject_age:Children (0-2 years old)

subject_sex:Male

subject_condition:Normal

122:

biospecimen:Urine

concentration_value:16.06 +/- 7.48

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Female

subject_condition:Normal

123:

biospecimen:Urine

concentration_value:2.15-224.84

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

124:

biospecimen:Urine

concentration_value:9.0667 +/- 5.707

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 13 years old)

subject_sex:Male

subject_condition:Normal

125:

biospecimen:Urine

concentration_value:10-68

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 13 years old)

subject_sex:Both

subject_condition:Normal

126:

biospecimen:Urine

concentration_value:19.335-100.541

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

127:

biospecimen:Urine

concentration_value:11.601 +/- 3.867

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

128:

biospecimen:Urine

concentration_value:11.601 +/- 3.867

concentration_units:umol/mmol creatinine

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

129:

biospecimen:Urine

concentration_value:3.1 +/- 1.5

concentration_units:umol/mmol creatinine

subject_age:Infant (1 - 6 months old)

subject_sex:Both

subject_condition:Normal

130:

biospecimen:Urine

concentration_value:3.2 +/- 1.9

concentration_units:umol/mmol creatinine

subject_age:Infant (6 months - <1 year old)

subject_sex:Both

subject_condition:Normal

131:

biospecimen:Urine

concentration_value:4.4 +- 1.6

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

132:

biospecimen:Urine

concentration_value:24.647-202.943

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

133:

biospecimen:Urine

concentration_value:1.933 +/- 1.0741

concentration_units:umol/mmol creatinine

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

134:

biospecimen:Urine

concentration_value:10.28 +/- 5.34

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

135:

biospecimen:Urine

concentration_value:68.22 (12-124.44)

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

136:

biospecimen:Urine

concentration_value:32.0 +/- 27.0

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

137:

biospecimen:Urine

concentration_value:29.0 +/- 21.7

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

138:

biospecimen:Urine

concentration_value:17.9 (3.6-56.1)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

139:

biospecimen:Urine

concentration_value:2.83-84.047

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

140:

biospecimen:Urine

concentration_value:5.6-15

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

141:

biospecimen:Urine

concentration_value:7-58

concentration_units:umol/mmol creatinine

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

142:

biospecimen:Urine

concentration_value:3-170

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

143:

biospecimen:Urine

concentration_value:3-170

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

144:

biospecimen:Urine

concentration_value:4.7

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

145:

biospecimen:Urine

concentration_value:34.8063 +/- 26.0145

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

146:

biospecimen:Urine

concentration_value:1.58-34.73

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

147:

biospecimen:Urine

concentration_value:226.12 +/- 158.28

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

148:

biospecimen:Urine

concentration_value:407.02 +/- 260.04

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

149:

biospecimen:Urine

concentration_value:520.08 +/- 327.87

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

150:

biospecimen:Urine

concentration_value:0-69

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Both

subject_condition:Normal

异常浓度
1:

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Oesophageal cancer

2:

biospecimen:Blood

concentration_value:128.2 +/- 55.3

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Heart Transplant

3:

biospecimen:Blood

concentration_value:70 (32-179)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Not Specified

patient_information:Lysinuric protein intolerance

4:

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

5:

biospecimen:Blood

concentration_value:180.5 (142-326)

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Male

patient_information:Lipoyltransferase 1 Deficiency

6:

biospecimen:Blood

concentration_value:220-384

concentration_units:uM

patient_age:Newborn (0-30 days old)

patient_sex:Both

patient_information:Citrullinemia type II, neonatal-onset

7:

biospecimen:Blood

concentration_value:1208-1472

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Hyperlysinemia I, familial

8:

biospecimen:Blood

concentration_value:713

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:

patient_information:Pyruvate carboxylase deficiency

9:

biospecimen:Blood

concentration_value:136

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:

patient_information:Pyruvate carboxylase deficiency

10:

biospecimen:Blood

concentration_value:135-831

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Male

patient_information:2,4-dienoyl-CoA reductase deficiency

11:

biospecimen:Blood

concentration_value:206 +/- 29

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Schizophrenia

12:

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

13:

biospecimen:Blood

concentration_value:186 +/- 28

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Schizophrenia

14:

biospecimen:Blood

concentration_value:103.04 (27.01)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy with fetus having congenital heart defect

15:

biospecimen:Blood

concentration_value:97.44 (29.48)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

16:

biospecimen:Blood

concentration_value:82.9

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Male

patient_information:Alpha-aminoadipic and alpha-ketoadipic aciduria

17:

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Pancreatic cancer

18:

biospecimen:Blood

concentration_value:147.5(112.8-185.0)

concentration_units:uM

patient_age:Children (1-13 uears old)

patient_sex:Both

patient_information:Environmental enteric dysfunction

19:

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Pancreatic ductal adenocarcinoma

20:

biospecimen:Blood

concentration_value:107

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Male

patient_information:Fumaric aciduria

21:

biospecimen:Blood

concentration_value:116 (89.4-136)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Lysinuric protein intolerance

22:

biospecimen:Blood

concentration_value:147 +/- 42

concentration_units:uM

patient_age:Children (1 - 13 years old)

patient_sex:Male

patient_information:Histidinuria

23:

biospecimen:Blood

concentration_value:185-396

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:L-2-hydroxyglutaric aciduria

24:

biospecimen:Blood

concentration_value:216.7 +/- 54.5

concentration_units:uM

patient_age:Elderly (>65 years old)

patient_sex:Both

patient_information:Alzheimer's disease

25:

biospecimen:Blood

concentration_value:24-73

concentration_units:uM

patient_age:Children (1 - 13 years old)

patient_sex:Both

patient_information:Lysinuric protein intolerance

26:

biospecimen:Blood

concentration_value:128.0 +/- 9.0

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Refractory localization-related epilepsy (RLE)

27:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:226

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Male

patient_information:2,4-dienoyl-CoA reductase deficiency

28:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:44.6 +/- 10.8

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Alzheimer's disease

29:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:60.000-94.500

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Female

patient_information:L-2-hydroxyglutaric aciduria

30:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:26.9 +/- 11.1

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Not Specified

patient_information:Leukemia

31:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:21.9 +/- 6.2

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Not Specified

patient_information:Leukemia

32:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

33:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal Cancer

34:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Autism

35:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Irritable bowel syndrome

36:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Ulcerative colitis

37:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Myalgic encephalomyelitis/chronic fatigue syndrome

38:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Crohns disease

39:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Ulcerative colitis

40:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Unclassified IBD

41:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

42:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Irritable Bowel Syndrome

43:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

44:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

45:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Crohn’s Disease

46:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Ulcerative Colitis

47:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Crohn's disease

48:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Ulcerative colitis

49:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

50:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Attachment loss 

51:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Missing teeth

52:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Periodontal Probing Depth

53:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Supragingival Calculus

54:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Oral cancer

55:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Breast cancer

56:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Not Specified

patient_information:Pancreatic cancer

57:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Not Specified

patient_information:Periodontal diseases

58:

biospecimen:Saliva

concentration_value:45.55 +/- 15.63

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Alzheimer's disease

59:

biospecimen:Saliva

concentration_value:41.71 +/- 22.55

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Frontotemporal lobe dementia

60:

biospecimen:Saliva

concentration_value:37.38 +/- 19.11

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Lewy body disease

61:

biospecimen:Urine

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal adenoma

62:

biospecimen:Urine

concentration_value:1.0489-5.518

concentration_units:umol/mmol creatinine

patient_age:Infant (0-1 year old)

patient_sex:Female

patient_information:Carbamoyl Phosphate Synthetase Deficiency

63:

biospecimen:Urine

concentration_value:34.402 +/- 30.429

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Eosinophilic esophagitis

64:

biospecimen:Urine

concentration_value:130.200-1873.600

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Cystinuria

65:

biospecimen:Urine

concentration_value:18.0 (7.0-29.0)

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Carbamoyl Phosphate Synthetase Deficiency

66:

biospecimen:Urine

concentration_value:2750.0 (500.0-5000.0)

concentration_units:umol/mmol creatinine

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Carbamoyl phosphate synthetase deficiency

67:

biospecimen:Urine

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Bladder cancer

68:

biospecimen:Urine

concentration_value:0.0039 - 0.0116

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:ADPKD

69:

biospecimen:Urine

concentration_value:1779

concentration_units:umol/mmol creatinine

patient_age:Infant (0-1 year old)

patient_sex:Male

patient_information:2,4-dienoyl-CoA reductase deficiency

70:

biospecimen:Urine

concentration_value:2050-18736

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Hyperlysinuria

71:

biospecimen:Urine

concentration_value:1413.757

concentration_units:umol/mmol creatinine

patient_age:Children (1-13 years old)

patient_sex:Female

patient_information:Hyperlysinuria

72:

biospecimen:Urine

concentration_value:41.840-220.880

concentration_units:umol/mmol creatinine

patient_age:Children (1-13 years old)

patient_sex:Female

patient_information:Dibasic Amino Aciduria I

73:

biospecimen:Urine

concentration_value:30.704-356.533

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Dibasic Amino Aciduria I

74:

biospecimen:Urine

concentration_value:3.414

concentration_units:umol/mmol creatinine

patient_age:Children (1-13 years old)

patient_sex:Male

patient_information:Alpha-aminoadipic and alpha-ketoadipic aciduria

75:

biospecimen:Urine

concentration_value:111.677-220.880

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Female

patient_information:Hyperdibasic aminoaciduria I

76:

biospecimen:Urine

concentration_value:1272.2

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Cystinuria

77:

biospecimen:Urine

concentration_value:268.300-365.200

concentration_units:umol/mmol creatinine

patient_age:Infant (0-1 year old)

patient_sex:Not Specified

patient_information:Fumaric aciduria

78:

biospecimen:Urine

concentration_value:30.704-137.431

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Hyperdibasic aminoaciduria I

79:

biospecimen:Urine

concentration_value:548-1317.200

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Both

patient_information:Lysinuric protein intolerance

80:

biospecimen:Urine

concentration_value:5.5 +/- 1.74

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Alzheimer's disease

81:

biospecimen:Urine

concentration_value:36-168

concentration_units:umol/mmol creatinine

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:L-2-hydroxyglutaric aciduria

82:

biospecimen:Urine

concentration_value:28.0899 +/- 25.2794

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Eosinophilic esophagitis

83:

biospecimen:Urine

concentration_value:18.5215 +/- 11.0832

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Gastroesophageal reflux disease

84:

biospecimen:Urine

concentration_value:101 +/- 13

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Propionic acidemia

85:

biospecimen:Urine

concentration_value:452.1 +/- 60.2

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Tyrosinemia I

86:

biospecimen:Urine

concentration_value:321.8 +/- 15.4

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Tyrosinemia I

87:

biospecimen:Urine

concentration_value:397.5 +/- 16.6

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Aminoaciduria

88:

biospecimen:Urine

concentration_value:1384-1742

concentration_units:umol/mmol creatinine

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Hyperlysinemia I, familial

疾病参考
1:

name:Refractory localization-related epilepsy

omim_id:

[1]:

reference_text:Rainesalo S, Keranen T, Palmio J, Peltola J, Oja SS, Saransaari P: Plasma and cerebrospinal fluid amino acids in epileptic patients. Neurochem Res. 2004 Jan;29(1):319-24.

pubmed_id:14992292

2:

name:Alzheimer's disease

omim_id:104300

[1]:

reference_text:Fonteh AN, Harrington RJ, Tsai A, Liao P, Harrington MG: Free amino acid and dipeptide changes in the body fluids from Alzheimer's disease subjects. Amino Acids. 2007 Feb;32(2):213-24. Epub 2006 Oct 10.

pubmed_id:17031479

[2]:

reference_text:Selley ML, Close DR, Stern SE: The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer's disease. Neurobiol Aging. 2002 May-Jun;23(3):383-8.

pubmed_id:11959400

[3]:

reference_text:Shetty HU, Holloway HW, Schapiro MB: Cerebrospinal fluid and plasma distribution of myo-inositol and other polyols in Alzheimer disease. Clin Chem. 1996 Feb;42(2):298-302.

pubmed_id:8595727

[4]:

reference_text:Jia JP, Jia JM, Zhou WD, Xu M, Chu CB, Yan X, Sun YX: Differential acetylcholine and choline concentrations in the cerebrospinal fluid of patients with Alzheimer's disease and vascular dementia. Chin Med J (Engl). 2004 Aug;117(8):1161-4.

pubmed_id:15361288

[5]:

reference_text:Redjems-Bennani N, Jeandel C, Lefebvre E, Blain H, Vidailhet M, Gueant JL: Abnormal substrate levels that depend upon mitochondrial function in cerebrospinal fluid from Alzheimer patients. Gerontology. 1998;44(5):300-4.

pubmed_id:9693263

[6]:

reference_text:Walter A, Korth U, Hilgert M, Hartmann J, Weichel O, Hilgert M, Fassbender K, Schmitt A, Klein J: Glycerophosphocholine is elevated in cerebrospinal fluid of Alzheimer patients. Neurobiol Aging. 2004 Nov-Dec;25(10):1299-303.

pubmed_id:15465626

[7]:

reference_text:Leoni V, Masterman T, Mousavi FS, Wretlind B, Wahlund LO, Diczfalusy U, Hillert J, Bjorkhem I: Diagnostic use of cerebral and extracerebral oxysterols. Clin Chem Lab Med. 2004 Feb;42(2):186-91.

pubmed_id:15061359

[8]:

reference_text:Raskind MA, Peskind ER, Holmes C, Goldstein DS: Patterns of cerebrospinal fluid catechols support increased central noradrenergic responsiveness in aging and Alzheimer's disease. Biol Psychiatry. 1999 Sep 15;46(6):756-65.

pubmed_id:10494443

[9]:

reference_text:Lovell MA, Markesbery WR: Ratio of 8-hydroxyguanine in intact DNA to free 8-hydroxyguanine is increased in Alzheimer disease ventricular cerebrospinal fluid. Arch Neurol. 2001 Mar;58(3):392-6.

pubmed_id:11255442

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reference_text:Zhang L, Jin H, Guo X, Yang Z, Zhao L, Tang S, Mo P, Wu K, Nie Y, Pan Y, Fan D: Distinguishing pancreatic cancer from chronic pancreatitis and healthy individuals by (1)H nuclear magnetic resonance-based metabonomic profiles. Clin Biochem. 2012 Sep;45(13-14):1064-9. doi: 10.1016/j.clinbiochem.2012.05.012. Epub 2012 May 19.

pubmed_id:22613268

[4]:

reference_text:OuYang D, Xu J, Huang H, Chen Z: Metabolomic profiling of serum from human pancreatic cancer patients using 1H NMR spectroscopy and principal component analysis. Appl Biochem Biotechnol. 2011 Sep;165(1):148-54. doi: 10.1007/s12010-011-9240-0. Epub 2011 Apr 20.

pubmed_id:21505807

[5]:

reference_text:Xie G, Lu L, Qiu Y, Ni Q, Zhang W, Gao YT, Risch HA, Yu H, Jia W: Plasma metabolite biomarkers for the detection of pancreatic cancer. J Proteome Res. 2015 Feb 6;14(2):1195-202. doi: 10.1021/pr501135f. Epub 2014 Dec 8.

pubmed_id:25429707

20:

name:Periodontal disease

omim_id:170650

[1]:

reference_text:Sugimoto M, Wong DT, Hirayama A, Soga T, Tomita M: Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles. Metabolomics. 2010 Mar;6(1):78-95. Epub 2009 Sep 10.

pubmed_id:20300169

21:

name:Frontotemporal dementia

omim_id:600274

[1]:

reference_text:Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6.

pubmed_id:23857558

22:

name:Lewy body disease

omim_id:

[1]:

reference_text:Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6.

pubmed_id:23857558

23:

name:Attachment loss

omim_id:

[1]:

reference_text:Liebsch C, Pitchika V, Pink C, Samietz S, Kastenmuller G, Artati A, Suhre K, Adamski J, Nauck M, Volzke H, Friedrich N, Kocher T, Holtfreter B, Pietzner M: The Saliva Metabolome in Association to Oral Health Status. J Dent Res. 2019 Jun;98(6):642-651. doi: 10.1177/0022034519842853. Epub 2019 Apr 26.

pubmed_id:31026179

24:

name:Missing teeth

omim_id:

[1]:

reference_text:Liebsch C, Pitchika V, Pink C, Samietz S, Kastenmuller G, Artati A, Suhre K, Adamski J, Nauck M, Volzke H, Friedrich N, Kocher T, Holtfreter B, Pietzner M: The Saliva Metabolome in Association to Oral Health Status. J Dent Res. 2019 Jun;98(6):642-651. doi: 10.1177/0022034519842853. Epub 2019 Apr 26.

pubmed_id:31026179

25:

name:Periodontal Probing Depth

omim_id:

[1]:

reference_text:Liebsch C, Pitchika V, Pink C, Samietz S, Kastenmuller G, Artati A, Suhre K, Adamski J, Nauck M, Volzke H, Friedrich N, Kocher T, Holtfreter B, Pietzner M: The Saliva Metabolome in Association to Oral Health Status. J Dent Res. 2019 Jun;98(6):642-651. doi: 10.1177/0022034519842853. Epub 2019 Apr 26.

pubmed_id:31026179

26:

name:Supragingival Calculus

omim_id:

[1]:

reference_text:Liebsch C, Pitchika V, Pink C, Samietz S, Kastenmuller G, Artati A, Suhre K, Adamski J, Nauck M, Volzke H, Friedrich N, Kocher T, Holtfreter B, Pietzner M: The Saliva Metabolome in Association to Oral Health Status. J Dent Res. 2019 Jun;98(6):642-651. doi: 10.1177/0022034519842853. Epub 2019 Apr 26.

pubmed_id:31026179

27:

name:Carbamoyl Phosphate Synthetase Deficiency

omim_id:237300

[1]:

reference_text:Ishida J, Iizuka R, Yamaguchi M: High-performance liquid chromatographic determination of 5-hydroxyindoles by post-column fluorescence derivatization. Analyst. 1993 Feb;118(2):165-9.

pubmed_id:7680187

[2]:

reference_text:Freeman JM, Nicholson JF, Schimke RT, Rowland LP, Carter S: Congenital hyperammonemia. Association with hyperglycinemia and decreased levels of carbamyl phosphate synthetase. Arch Neurol. 1970 Nov;23(5):430-7.

pubmed_id:5471650

[3]:

reference_text:MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de)

pubmed_id:

28:

name:Autosomal dominant polycystic kidney disease

omim_id:601313

[1]:

reference_text:Wang D, Strandgaard S, Borresen ML, Luo Z, Connors SG, Yan Q, Wilcox CS: Asymmetric dimethylarginine and lipid peroxidation products in early autosomal dominant polycystic kidney disease. Am J Kidney Dis. 2008 Feb;51(2):184-91. doi: 10.1053/j.ajkd.2007.09.020.

pubmed_id:18215696

[2]:

reference_text:Gronwald W, Klein MS, Zeltner R, Schulze BD, Reinhold SW, Deutschmann M, Immervoll AK, Boger CA, Banas B, Eckardt KU, Oefner PJ: Detection of autosomal dominant polycystic kidney disease by NMR spectroscopic fingerprinting of urine. Kidney Int. 2011 Jun;79(11):1244-53. doi: 10.1038/ki.2011.30. Epub 2011 Mar 9.

pubmed_id:21389975

29:

name:Propionic acidemia

omim_id:606054

[1]:

reference_text:Scholl-Burgi S, Haberlandt E, Gotwald T, Albrecht U, Baumgartner Sigl S, Rauchenzauner M, Rostasy K, Karall D: Stroke-like episodes in propionic acidemia caused by central focal metabolic decompensation. Neuropediatrics. 2009 Apr;40(2):76-81. doi: 10.1055/s-0029-1231065. Epub 2009 Oct 6.

pubmed_id:19809936

[2]:

reference_text:Gronwald W, Klein MS, Kaspar H, Fagerer SR, Nurnberger N, Dettmer K, Bertsch T, Oefner PJ: Urinary metabolite quantification employing 2D NMR spectroscopy. Anal Chem. 2008 Dec 1;80(23):9288-97. doi: 10.1021/ac801627c.

pubmed_id:19551947

[3]:

reference_text:Thompson GN, Chalmers RA, Walter JH, Bresson JL, Lyonnet SL, Reed PJ, Saudubray JM, Leonard JV, Halliday D: The use of metronidazole in management of methylmalonic and propionic acidaemias. Eur J Pediatr. 1990 Aug;149(11):792-6.

pubmed_id:2226555

[4]:

reference_text:Riemersma M, Hazebroek MR, Helderman-van den Enden ATJM, Salomons GS, Ferdinandusse S, Brouwers MCGJ, van der Ploeg L, Heymans S, Glatz JFC, van den Wijngaard A, Krapels IPC, Bierau J, Brunner HG: Propionic acidemia as a cause of adult-onset dilated cardiomyopathy. Eur J Hum Genet. 2017 Nov;25(11):1195-1201. doi: 10.1038/ejhg.2017.127. Epub 2017 Aug 30.

pubmed_id:28853722

[5]:

reference_text:MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de)

pubmed_id:

30:

name:Tyrosinemia I

omim_id:276700

[1]:

reference_text:Gronwald W, Klein MS, Kaspar H, Fagerer SR, Nurnberger N, Dettmer K, Bertsch T, Oefner PJ: Urinary metabolite quantification employing 2D NMR spectroscopy. Anal Chem. 2008 Dec 1;80(23):9288-97. doi: 10.1021/ac801627c.

pubmed_id:19551947

[2]:

reference_text:Nakamura K, Matsumoto S, Mitsubuchi H, Endo F: Diagnosis and treatment of hereditary tyrosinemia in Japan. Pediatr Int. 2015;57(1):37-40. doi: 10.1111/ped.12550.

pubmed_id:25443793

[3]:

reference_text:Gissen P, Preece MA, Willshaw HA, McKiernan PJ: Ophthalmic follow-up of patients with tyrosinaemia type I on NTBC. J Inherit Metab Dis. 2003;26(1):13-6.

pubmed_id:12872835

[4]:

reference_text:Han LS, Ye J, Qiu WJ, Zhang HW, Wang Y, Ji WJ, Gao XL, Li XY, Jin J, Gu XF: [Application of succinylacetone levels measurement in the blood and urine in the diagnosis of tyrosinemia type 1]. Zhonghua Er Ke Za Zhi. 2012 Feb;50(2):126-30.

pubmed_id:22455637

[5]:

reference_text:MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de)

pubmed_id:

[6]:

reference_text:Physician's Guide to the Laboratory Diagnosis of Metabolic Diseases. 2nd ed. Berlin, Germany, Springer, 2003

pubmed_id:

31:

name:Eosinophilic esophagitis

omim_id:610247

[1]:

reference_text:Mordechai, Hien, and David S. Wishart

pubmed_id:

32:

name:Hyperdibasic aminoaciduria I

omim_id:222690

[1]:

reference_text:Whelan DT, Scriver CR: Hyperdibasicaminoaciduria: an inherited disorder of amino acid transport. Pediatr Res. 1968 Nov;2(6):525-34.

pubmed_id:5727921

33:

name:Cystinuria

omim_id:220100

[1]:

reference_text:Sakhaee K: Pathogenesis and medical management of cystinuria. Semin Nephrol. 1996 Sep;16(5):435-47.

pubmed_id:8890399

[2]:

reference_text:Fjellstedt E, Harnevik L, Jeppsson JO, Tiselius HG, Soderkvist P, Denneberg T: Urinary excretion of total cystine and the dibasic amino acids arginine, lysine and ornithine in relation to genetic findings in patients with cystinuria treated with sulfhydryl compounds. Urol Res. 2003 Dec;31(6):417-25. Epub 2003 Oct 25.

pubmed_id:14586528

[3]:

reference_text:Rodriguez LM, Santos F, Malaga S, Martinez V: Effect of a low sodium diet on urinary elimination of cystine in cystinuric children. Nephron. 1995;71(4):416-8.

pubmed_id:8587621

[4]:

reference_text:MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de)

pubmed_id:

34:

name:Alpha-aminoadipic and alpha-ketoadipic aciduria

omim_id:

[1]:

reference_text:Takechi T, Okada T, Wakiguchi H, Morita H, Kurashige T, Sugahara K, Kodama H: Identification of N-acetyl-alpha-aminoadipic acid in the urine of a patient with alpha-aminoadipic and alpha-ketoadipic aciduria. J Inherit Metab Dis. 1993;16(1):119-26.

pubmed_id:8487492

35:

name:2,4-dienoyl-CoA reductase deficiency

omim_id:616034

[1]:

reference_text:Houten SM, Denis S, Te Brinke H, Jongejan A, van Kampen AH, Bradley EJ, Baas F, Hennekam RC, Millington DS, Young SP, Frazier DM, Gucsavas-Calikoglu M, Wanders RJ: Mitochondrial NADP(H) deficiency due to a mutation in NADK2 causes dienoyl-CoA reductase deficiency with hyperlysinemia. Hum Mol Genet. 2014 Sep 15;23(18):5009-16. doi: 10.1093/hmg/ddu218. Epub 2014 May 8.

pubmed_id:24847004

36:

name:Hyperlysinuria

omim_id:247950

[1]:

reference_text:Omura K, Yamanaka N, Higami S, Matsuoka O, Fujimoto A: Lysine malabsorption syndrome: a new type of transport defect. Pediatrics. 1976 Jan;57(1):102-5.

pubmed_id:1246485

[2]:

reference_text:Fjellstedt E, Harnevik L, Jeppsson JO, Tiselius HG, Soderkvist P, Denneberg T: Urinary excretion of total cystine and the dibasic amino acids arginine, lysine and ornithine in relation to genetic findings in patients with cystinuria treated with sulfhydryl compounds. Urol Res. 2003 Dec;31(6):417-25. Epub 2003 Oct 25.

pubmed_id:14586528

37:

name:Hyperlysinemia I, familial

omim_id:238700

[1]:

reference_text:Tondo M, Calpena E, Arriola G, Sanz P, Martorell L, Ormazabal A, Castejon E, Palacin M, Ugarte M, Espinos C, Perez B, Perez-Duenas B, Perez-Cerda C, Artuch R: Clinical, biochemical, molecular and therapeutic aspects of 2 new cases of 2-aminoadipic semialdehyde synthase deficiency. Mol Genet Metab. 2013 Nov;110(3):231-6. doi: 10.1016/j.ymgme.2013.06.021. Epub 2013 Jul 6.

pubmed_id:23890588

KEGG数据库编号
C00047
DrugBank数据库编号
DB00123
foodb数据库编号
FDB000474
ChemSpider数据库编号
5747
公共化学化合物编号
5962
PDB数据库编号
LYS
生物利益的化学实体数据库编号
18019
knapsack数据库编号
C00001378
维基百科编号
Lysine
代谢途径的数据库编号
LYS
苯酚资源管理器化合物数据库编号
比格数据库编号
33655
梅林编号
5200
虚拟机身份证编号
LYS_L
fbonto数据库编号
综合参考
Rothstein, Morton. DL-Lysine-6-C14 and DL-a-aminoadipic acid-6-C14. Biochemical Preparations (1961), 8 85-8.
一般参考
1:

protein_accession:HMDBP00402

name:Histone-lysine N-methyltransferase, H3 lysine-79 specific

uniprot_id:Q8TEK3

gene_name:DOT1L

protein_type:Unknown

2:

protein_accession:HMDBP00404

name:Histone-lysine N-methyltransferase SETD7

uniprot_id:Q8WTS6

gene_name:SETD7

protein_type:Unknown

3:

protein_accession:HMDBP00410

name:Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific

uniprot_id:Q96L73

gene_name:NSD1

protein_type:Unknown

4:

protein_accession:HMDBP00411

name:Histone-lysine N-methyltransferase SETDB1

uniprot_id:Q15047

gene_name:SETDB1

protein_type:Unknown

5:

protein_accession:HMDBP00419

name:Histone-lysine N-methyltransferase EHMT2

uniprot_id:Q96KQ7

gene_name:EHMT2

protein_type:Unknown

6:

protein_accession:HMDBP00425

name:Histone-lysine N-methyltransferase EHMT1

uniprot_id:Q9H9B1

gene_name:EHMT1

protein_type:Unknown

7:

protein_accession:HMDBP00460

name:Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

uniprot_id:Q02809

gene_name:PLOD1

protein_type:Unknown

8:

protein_accession:HMDBP00461

name:Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

uniprot_id:O00469

gene_name:PLOD2

protein_type:Unknown

9:

protein_accession:HMDBP00462

name:Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

uniprot_id:O60568

gene_name:PLOD3

protein_type:Unknown

10:

protein_accession:HMDBP00546

name:Biotinidase

uniprot_id:P43251

gene_name:BTD

protein_type:Enzyme

11:

protein_accession:HMDBP00613

name:Lysine--tRNA ligase

uniprot_id:Q15046

gene_name:KARS

protein_type:Enzyme

12:

protein_accession:HMDBP00852

name:Alpha-aminoadipic semialdehyde synthase, mitochondrial

uniprot_id:Q9UDR5

gene_name:AASS

protein_type:Unknown

13:

protein_accession:HMDBP01867

name:PR domain zinc finger protein 2

uniprot_id:Q13029

gene_name:PRDM2

protein_type:Unknown

14:

protein_accession:HMDBP01970

name:Histone-lysine N-methyltransferase MLL

uniprot_id:Q03164

gene_name:MLL

protein_type:Unknown

15:

protein_accession:HMDBP03179

name:Histone-lysine N-methyltransferase MLL3

uniprot_id:Q8NEZ4

gene_name:MLL3

protein_type:Unknown

16:

protein_accession:HMDBP07400

name:Aminoadipate-semialdehyde synthase

uniprot_id:A4D0W4

gene_name:AASS

protein_type:Enzyme

17:

protein_accession:HMDBP08844

name:Carnosine synthase 1

uniprot_id:A5YM72

gene_name:CARNS1

protein_type:Unknown

18:

protein_accession:HMDBP09013

name:Histone-lysine N-methyltransferase EZH2

uniprot_id:Q15910

gene_name:EZH2

protein_type:Unknown

19:

protein_accession:HMDBP09019

name:Histone-lysine N-methyltransferase MLL2

uniprot_id:O14686

gene_name:MLL2

protein_type:Unknown

20:

protein_accession:HMDBP09020

name:Histone-lysine N-methyltransferase MLL4

uniprot_id:Q9UMN6

gene_name:WBP7

protein_type:Unknown

21:

protein_accession:HMDBP09022

name:Histone-lysine N-methyltransferase NSD2

uniprot_id:O96028

gene_name:WHSC1

protein_type:Unknown

22:

protein_accession:HMDBP09023

name:Histone-lysine N-methyltransferase NSD3

uniprot_id:Q9BZ95

gene_name:WHSC1L1

protein_type:Unknown

23:

protein_accession:HMDBP09035

name:Histone-lysine N-methyltransferase SETD2

uniprot_id:Q9BYW2

gene_name:SETD2

protein_type:Unknown

24:

protein_accession:HMDBP09184

name:Lysine-specific demethylase 2A

uniprot_id:Q9Y2K7

gene_name:KDM2A

protein_type:Enzyme

25:

protein_accession:HMDBP09185

name:Lysine-specific demethylase 2B

uniprot_id:Q8NHM5

gene_name:KDM2B

protein_type:Enzyme

蛋白质结合
1:

reference_text:Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762.

pubmed_id:19212411

2:

reference_text:Silwood CJ, Lynch E, Claxson AW, Grootveld MC: 1H and (13)C NMR spectroscopic analysis of human saliva. J Dent Res. 2002 Jun;81(6):422-7.

pubmed_id:12097436

3:

reference_text:Nicholson JK, O'Flynn MP, Sadler PJ, Macleod AF, Juul SM, Sonksen PH: Proton-nuclear-magnetic-resonance studies of serum, plasma and urine from fasting normal and diabetic subjects. Biochem J. 1984 Jan 15;217(2):365-75.

pubmed_id:6696735

4:

reference_text:Engelborghs S, Marescau B, De Deyn PP: Amino acids and biogenic amines in cerebrospinal fluid of patients with Parkinson's disease. Neurochem Res. 2003 Aug;28(8):1145-50.

pubmed_id:12834252

5:

reference_text:Hagenfeldt L, Bjerkenstedt L, Edman G, Sedvall G, Wiesel FA: Amino acids in plasma and CSF and monoamine metabolites in CSF: interrelationship in healthy subjects. J Neurochem. 1984 Mar;42(3):833-7.

pubmed_id:6198473

6:

reference_text:Peng CT, Wu KH, Lan SJ, Tsai JJ, Tsai FJ, Tsai CH: Amino acid concentrations in cerebrospinal fluid in children with acute lymphoblastic leukemia undergoing chemotherapy. Eur J Cancer. 2005 May;41(8):1158-63. Epub 2005 Apr 14.

pubmed_id:15911239

7:

reference_text:Cynober LA: Plasma amino acid levels with a note on membrane transport: characteristics, regulation, and metabolic significance. Nutrition. 2002 Sep;18(9):761-6.

pubmed_id:12297216

8:

reference_text:Rainesalo S, Keranen T, Palmio J, Peltola J, Oja SS, Saransaari P: Plasma and cerebrospinal fluid amino acids in epileptic patients. Neurochem Res. 2004 Jan;29(1):319-24.

pubmed_id:14992292

9:

reference_text:Kranz BR: Detection of rare malignant cells and their apoptotic fragments in cerebrospinal fluid. Lancet. 2000 Oct 7;356(9237):1242-4.

pubmed_id:11072949

10:

reference_text:Hajishengallis G, Koga T, Russell MW: Affinity and specificity of the interactions between Streptococcus mutans antigen I/II and salivary components. J Dent Res. 1994 Sep;73(9):1493-502.

pubmed_id:7523469

11:

reference_text:Pahler A, Parker J, Dekant W: Dose-dependent protein adduct formation in kidney, liver, and blood of rats and in human blood after perchloroethene inhalation. Toxicol Sci. 1999 Mar;48(1):5-13.

pubmed_id:10330678

12:

reference_text:Faraasen S, Voros J, Csucs G, Textor M, Merkle HP, Walter E: Ligand-specific targeting of microspheres to phagocytes by surface modification with poly(L-lysine)-grafted poly(ethylene glycol) conjugate. Pharm Res. 2003 Feb;20(2):237-46.

pubmed_id:12636162

13:

reference_text:Brunk E, Sahoo S, Zielinski DC, Altunkaya A, Drager A, Mih N, Gatto F, Nilsson A, Preciat Gonzalez GA, Aurich MK, Prlic A, Sastry A, Danielsdottir AD, Heinken A, Noronha A, Rose PW, Burley SK, Fleming RMT, Nielsen J, Thiele I, Palsson BO: Recon3D enables a three-dimensional view of gene variation in human metabolism. Nat Biotechnol. 2018 Mar;36(3):272-281. doi: 10.1038/nbt.4072. Epub 2018 Feb 19.

pubmed_id:29457794

14:

reference_text:Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043.

pubmed_id:32033212

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