创建日期
2005-11-16 15:48:42 UTC
更新日期
2021-09-14 15:38:58 UTC
描述
Inosinic acid, also known as inosine monophosphate, IMP, 5'-inosinate or 5'-IMP, belongs to the class of organic compounds known as purine ribonucleoside monophosphates. These are nucleotides consisting of a purine base linked to a ribose to which one monophosphate group is attached. IMP is also classified as a nucleotide (a nucleoside monophosphate). Inosinic acid exists in all living species, ranging from bacteria to plants to humans. IMP is widely used as a flavor enhancer. In the food industry it is known as E number reference E630. Inosinic acid can be converted into various salts including disodium inosinate (E631), dipotassium inosinate (E632), and calcium inosinate (E633). These three inosinate compounds are used as flavor enhancers for the basic taste umami. These inosinate salts are mostly used in soups, sauces, and seasonings for the intensification and balance of the flavor of meat. Inosinic acid is typically obtained from chicken byproducts or other meat industry waste. Inosinic acid or IMP is important in metabolism. It is the ribonucleotide of hypoxanthine and the first nucleotide formed during the synthesis of purine nucleotides. It can also be formed by the deamination of adenosine monophosphate by AMP deaminase. GMP is formed by the inosinate oxidation to xanthylate (XMP). Within humans, inosinic acid participates in a number of enzymatic reactions. In particular, inosinic acid can be converted into phosphoribosyl formamidocarboxamide; which is catalyzed by the bifunctional purine biosynthesis protein. In addition, inosinic acid can be converted into xanthylic acid; which is catalyzed by the enzyme inosine-5'-monophosphate dehydrogenase 1.
同义词
1:2'-Inosine-5'-monophosphate
2:5'-IMP
3:5'-Inosinate
4:5'-Inosine monophosphate
5:5'-Inosinic acid
6:Hypoxanthosine 5'-monophosphate
7:Inosine 5'-monophosphate
8:Inosine 5'-phosphate
9:Inosine monophosphate
10:Ribosylhypoxanthine monophosphate
11:2'-Inosine-5'-monophosphoric acid
12:5'-Inosine monophosphoric acid
13:Hypoxanthosine 5'-monophosphoric acid
14:Inosine 5'-monophosphoric acid
15:Inosine 5'-phosphoric acid
16:Inosine monophosphoric acid
17:Ribosylhypoxanthine monophosphoric acid
18:Inosinate
19:IMP
20:Inosine-5'-monophosphate
21:Inosinic acids
22:Inosinate, sodium
23:monoPhosphate, inosine
24:monoPhosphate, ribosylhypoxanthine
25:Sodium inosinate
26:Acid, inosinic
27:Acids, inosinic
化学名称
{[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-6,9-dihydro-1H-purin-9-yl)oxolan-2-yl]methoxy}phosphonic acid
传统名称
inosine-5'-monophosphate
代谢物结构字符串
O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)N1C=NC2=C1N=CNC2=O
inchi标识符
InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
印记键
GRSZFWQUAKGDAV-KQYNXXCUSA-N
分类学
description: belongs to the class of organic compounds known as purine ribonucleoside monophosphates. These are nucleotides consisting of a purine base linked to a ribose to which one monophosphate group is attached.
description:Purine ribonucleoside monophosphates
kingdom:Organic compounds
super_class:Nucleosides, nucleotides, and analogues
class:Purine nucleotides
sub_class:Purine ribonucleotides
molecular_framework:Aromatic heteropolycyclic compounds
1:1,2-diols
2:6-oxopurines
3:Azacyclic compounds
4:Glycosylamines
5:Heteroaromatic compounds
6:Hydrocarbon derivatives
7:Hypoxanthines
8:Lactams
9:Monoalkyl phosphates
10:Monosaccharide phosphates
11:N-substituted imidazoles
12:Organic oxides
13:Organonitrogen compounds
14:Organopnictogen compounds
15:Oxacyclic compounds
16:Pentose phosphates
17:Pyrimidones
18:Secondary alcohols
19:Tetrahydrofurans
20:Vinylogous amides
21:1,2-diol
22:6-oxopurine
23:Alcohol
24:Alkyl phosphate
25:Aromatic heteropolycyclic compound
26:Azacycle
27:Azole
28:Glycosyl compound
29:Heteroaromatic compound
30:Hydrocarbon derivative
31:Hypoxanthine
32:Imidazole
33:Imidazopyrimidine
34:Lactam
35:Monoalkyl phosphate
36:Monosaccharide
37:Monosaccharide phosphate
38:N-glycosyl compound
39:N-substituted imidazole
40:Organic nitrogen compound
41:Organic oxide
42:Organic oxygen compound
43:Organic phosphoric acid derivative
44:Organoheterocyclic compound
45:Organonitrogen compound
46:Organooxygen compound
47:Organopnictogen compound
48:Oxacycle
49:Pentose monosaccharide
50:Pentose phosphate
51:Pentose-5-phosphate
52:Phosphoric acid ester
53:Purine
54:Purine ribonucleoside monophosphate
55:Pyrimidine
56:Pyrimidone
57:Secondary alcohol
58:Tetrahydrofuran
59:Vinylogous amide
60:inosine phosphate
61:purine ribonucleoside 5'-monophosphate
本体论
term:Physiological effect
definition:The effect on an organism physiology, resulting from its exposure to a chemical.
parent_id:
level:1
type:parent
term:Health effect
definition:A health condition or observation associated with a stimuli or with a biological activity of a chemical.
parent_id:7693
*level:2
type:parent
term:Health condition
definition:A health effect that consists on short or long-term disease, condition, disorder, syndrome or constant abnormality.
parent_id:7694
**level:3
type:parent
term:Febrile seizures
definition:
parent_id:7695
***level:4
type:child
synonym:Febrile convulsion
synonym:Febrile convulsions
synonym:Febrile seizure
term:Disposition
definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.
parent_id:
level:1
type:parent
term:Route of exposure
definition:A mean by which a chemical agent comes in contact with an organism, either under intended or unintended circumstances.
parent_id:7724
*level:2
type:parent
term:Enteral
definition:Chemical exposure via the alimentary canal (mouth to anus).
parent_id:7743
**level:3
type:parent
term:Ingestion
definition:Chemical exposure facilitated by entry through the mouth.
parent_id:7744
***level:4
type:child
synonym:Digestion
term:Source
definition:Natural or synthetic origin of a chemical.
parent_id:7724
*level:2
type:parent
term:Endogenous
definition:
parent_id:7735
**level:3
type:child
term:Food
definition:
parent_id:7735
**level:3
type:child
term:Biological
definition:A living organism (species or a higher taxonomy rank), in which a chemical can be found.
parent_id:7735
**level:3
type:parent
term:Plant
definition:A living organism belonging to the kingdom plantea. typically, it grows in a permanent site, absorbs water and inorganic substances through its roots, and synthesizes nutrients in its leaves by photosynthesis using the green pigment chlorophyll. examples incude trees, shrubs, herbs, grasses, ferns, and mosses.
parent_id:7736
***level:4
type:parent
synonym:Flora
term:Animal
definition:A living organism belonging to the kingdom animalia. it feeds on organic matter, typically having specialized sense organs and nervous system and able to respond rapidly to stimuli.
parent_id:7736
***level:4
type:child
synonym:Fauna
term:Biological location
definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.
parent_id:7724
*level:2
type:parent
term:Tissue and substructures
definition:An anatomical organizational level including multiple cells yet not comprising a complete organ .
parent_id:7725
**level:3
type:parent
term:All tissues
definition:All tissues in the body of the organism.
parent_id:7729
***level:4
type:child
term:Biofluid and excreta
definition:A liquid, semi-solid or solid material originating in the body.
parent_id:7725
**level:3
type:parent
term:Feces
definition:The material discharged from the bowel during defecation. It consists of undigested food, intestinal mucus, epithelial cells, and bacteria.
parent_id:7731
***level:4
type:child
synonym:Fecal
synonym:Stool
synonym:Faecal
synonym:Faeces
term:Blood
definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.
parent_id:7731
***level:4
type:child
term:Cerebrospinal fluid
definition:The fluid that is contained within the brain ventricles, the subarachnoid space and the central canal of the spinal cord. (nci).
parent_id:7731
***level:4
type:child
synonym:Csf
term:Subcellular
definition:An anatomical organizational level including a component within a biological cell .
parent_id:7725
**level:3
type:parent
term:Cytoplasm
definition:The portion of the cell contained within the plasma membrane but excluding the nucleus.
parent_id:7730
***level:4
type:child
synonym:Cytoplasma
term:Mitochondria
definition:
parent_id:7730
***level:4
type:child
term:Cell and elements
definition:An anatomical organizational level comprising of a single cell (or a fragment in some exceptions). a cell is defined by its type or function. it is the smallest unit of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid.
parent_id:7725
**level:3
type:parent
term:Extracellular
definition:The space external to the outermost structure of a cell.
parent_id:7732
***level:4
type:child
synonym:Extracellular region
term:Process
definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.
parent_id:
level:1
type:parent
term:Naturally occurring process
definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.
parent_id:7659
*level:2
type:parent
term:Biological process
definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.
parent_id:7660
**level:3
type:parent
term:Biochemical pathway
definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.
parent_id:7661
***level:4
type:parent
term:Role
definition:The purpose or function assumed by a chemical, either naturally or as intended by humans .
parent_id:
level:1
type:parent
term:Industrial application
definition:The assumed function of a chemical utilized by human.
parent_id:7671
*level:2
type:parent
term:Pharmaceutical industry
definition:A pharmacologic activity for which a chemical substance is utilized owing to its biological role.
parent_id:7678
**level:3
type:parent
term:Pharmaceutical
definition:
parent_id:7679
***level:4
type:child
预测性质
1:
kind:logp
value:-2.04
source:ALOGPS
2:
kind:logs
value:-2.06
source:ALOGPS
3:
kind:solubility
value:3.05 g/L
source:ALOGPS
4:
kind:logp
value:-2.9
source:ChemAxon
5:
kind:pka_strongest_acidic
value:1.31
source:ChemAxon
6:
kind:pka_strongest_basic
value:0.49
source:ChemAxon
7:
kind:iupac
value:{[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-6,9-dihydro-1H-purin-9-yl)oxolan-2-yl]methoxy}phosphonic acid
source:ChemAxon
8:
kind:average_mass
value:348.206
source:ChemAxon
9:
kind:mono_mass
value:348.047099924
source:ChemAxon
10:
kind:smiles
value:O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)N1C=NC2=C1N=CNC2=O
source:ChemAxon
11:
kind:formula
value:C10H13N4O8P
source:ChemAxon
12:
kind:inchi
value:InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
source:ChemAxon
13:
kind:inchikey
value:GRSZFWQUAKGDAV-KQYNXXCUSA-N
source:ChemAxon
14:
kind:polar_surface_area
value:175.73
source:ChemAxon
15:
kind:refractivity
value:72.2
source:ChemAxon
16:
kind:polarizability
value:29.14
source:ChemAxon
17:
kind:rotatable_bond_count
value:4
source:ChemAxon
18:
kind:acceptor_count
value:9
source:ChemAxon
19:
kind:donor_count
value:5
source:ChemAxon
20:
kind:physiological_charge
value:-2
source:ChemAxon
21:
kind:formal_charge
value:0
source:ChemAxon
22:
kind:number_of_rings
value:3
source:ChemAxon
23:
kind:bioavailability
value:Yes
source:ChemAxon
24:
kind:rule_of_five
value:Yes
source:ChemAxon
25:
kind:ghose_filter
value:No
source:ChemAxon
26:
kind:veber_rule
value:No
source:ChemAxon
27:
kind:mddr_like_rule
value:No
source:ChemAxon
1:
type:Specdb::CMs
spectrum_id:2210
2:
type:Specdb::CMs
spectrum_id:12309
3:
type:Specdb::CMs
spectrum_id:31049
4:
type:Specdb::CMs
spectrum_id:32262
5:
type:Specdb::CMs
spectrum_id:37338
6:
type:Specdb::CMs
spectrum_id:153039
7:
type:Specdb::NmrTwoD
spectrum_id:983
8:
type:Specdb::NmrTwoD
spectrum_id:1187
9:
type:Specdb::NmrOneD
spectrum_id:1142
10:
type:Specdb::NmrOneD
spectrum_id:4857
11:
type:Specdb::NmrOneD
spectrum_id:4858
12:
type:Specdb::NmrOneD
spectrum_id:6012
13:
type:Specdb::NmrOneD
spectrum_id:6013
14:
type:Specdb::NmrOneD
spectrum_id:6014
15:
type:Specdb::NmrOneD
spectrum_id:6015
16:
type:Specdb::NmrOneD
spectrum_id:6016
17:
type:Specdb::NmrOneD
spectrum_id:6017
18:
type:Specdb::NmrOneD
spectrum_id:6018
19:
type:Specdb::NmrOneD
spectrum_id:6019
20:
type:Specdb::NmrOneD
spectrum_id:6020
21:
type:Specdb::NmrOneD
spectrum_id:6021
22:
type:Specdb::NmrOneD
spectrum_id:6022
23:
type:Specdb::NmrOneD
spectrum_id:6023
24:
type:Specdb::NmrOneD
spectrum_id:6024
25:
type:Specdb::NmrOneD
spectrum_id:6025
26:
type:Specdb::NmrOneD
spectrum_id:6026
27:
type:Specdb::NmrOneD
spectrum_id:6027
28:
type:Specdb::NmrOneD
spectrum_id:6028
29:
type:Specdb::NmrOneD
spectrum_id:6029
30:
type:Specdb::NmrOneD
spectrum_id:6030
31:
type:Specdb::NmrOneD
spectrum_id:6031
32:
type:Specdb::MsMs
spectrum_id:277
33:
type:Specdb::MsMs
spectrum_id:278
34:
type:Specdb::MsMs
spectrum_id:279
35:
type:Specdb::MsMs
spectrum_id:3341
36:
type:Specdb::MsMs
spectrum_id:3342
37:
type:Specdb::MsMs
spectrum_id:178446
38:
type:Specdb::MsMs
spectrum_id:178447
39:
type:Specdb::MsMs
spectrum_id:178448
40:
type:Specdb::MsMs
spectrum_id:180765
41:
type:Specdb::MsMs
spectrum_id:180766
42:
type:Specdb::MsMs
spectrum_id:180767
43:
type:Specdb::MsMs
spectrum_id:439080
44:
type:Specdb::MsMs
spectrum_id:448024
45:
type:Specdb::MsMs
spectrum_id:2235630
46:
type:Specdb::MsMs
spectrum_id:2237725
47:
type:Specdb::MsMs
spectrum_id:2239841
48:
type:Specdb::MsMs
spectrum_id:2241882
49:
type:Specdb::MsMs
spectrum_id:2243958
50:
type:Specdb::MsMs
spectrum_id:2243989
51:
type:Specdb::MsMs
spectrum_id:2244107
52:
type:Specdb::MsMs
spectrum_id:2246001
53:
type:Specdb::MsMs
spectrum_id:2246086
54:
type:Specdb::MsMs
spectrum_id:2246181
55:
type:Specdb::MsMs
spectrum_id:2246201
56:
type:Specdb::MsMs
spectrum_id:2248069
生物学性质
1:
cellular:(1):Cytoplasm
cellular:(2):Extracellular
cellular:(3):Mitochondria
2:
biospecimen:(1):Blood
biospecimen:(2):Cellular Cytoplasm
biospecimen:(3):Cerebrospinal Fluid (CSF)
biospecimen:(4):Feces
3:
tissue:(1):All Tissues
4:
[1]:
name:Adenine phosphoribosyltransferase deficiency (APRT)
smpdb_id:SMP00535
kegg_map_id:
[2]:
name:Adenosine Deaminase Deficiency
smpdb_id:SMP00144
kegg_map_id:
[3]:
name:Adenylosuccinate Lyase Deficiency
smpdb_id:SMP00167
kegg_map_id:
[4]:
name:AICA-Ribosiduria
smpdb_id:SMP00168
kegg_map_id:
[5]:
name:Aspartate Metabolism
smpdb_id:SMP00067
kegg_map_id:map00250
[6]:
name:Azathioprine Action Pathway
smpdb_id:SMP00427
kegg_map_id:
[7]:
name:Canavan Disease
smpdb_id:SMP00175
kegg_map_id:
[8]:
name:Gout or Kelley-Seegmiller Syndrome
smpdb_id:SMP00365
kegg_map_id:
[9]:
name:Hypoacetylaspartia
smpdb_id:SMP00192
kegg_map_id:
[10]:
name:Lesch-Nyhan Syndrome (LNS)
smpdb_id:SMP00364
kegg_map_id:
[11]:
name:Mercaptopurine Action Pathway
smpdb_id:SMP00428
kegg_map_id:
[12]:
name:Mitochondrial DNA depletion syndrome
smpdb_id:SMP00536
kegg_map_id:
[13]:
name:Molybdenum Cofactor Deficiency
smpdb_id:SMP00203
kegg_map_id:
[14]:
name:Myoadenylate deaminase deficiency
smpdb_id:SMP00537
kegg_map_id:
[15]:
name:Purine metabolism
smpdb_id:
kegg_map_id:map00230
[16]:
name:Purine Nucleoside Phosphorylase Deficiency
smpdb_id:SMP00210
kegg_map_id:
[17]:
name:Thioguanine Action Pathway
smpdb_id:SMP00430
kegg_map_id:
[18]:
name:Xanthine Dehydrogenase Deficiency (Xanthinuria)
smpdb_id:SMP00220
kegg_map_id:
[19]:
name:Xanthinuria type I
smpdb_id:SMP00512
kegg_map_id:
[20]:
name:Xanthinuria type II
smpdb_id:SMP00513
kegg_map_id:
正常浓度
1:
biospecimen:Blood
concentration_value:63.0 +/- 41.0
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
2:
biospecimen:Cellular Cytoplasm
concentration_value:10
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
3:
biospecimen:Cerebrospinal Fluid (CSF)
concentration_value:3.19 (0.00 +/- 19.70)
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
4:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Children (6 - 18 years old)
subject_sex:Not Specified
subject_condition:Normal
异常浓度
1:
biospecimen:Cerebrospinal Fluid (CSF)
concentration_value:2.31(0.00-41.40)
concentration_units:uM
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Simple febrile seizures
2:
biospecimen:Cerebrospinal Fluid (CSF)
concentration_value:2.48 (0.00 +/- 27.20)
concentration_units:uM
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Complex febrile seizures
3:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Children (6 - 18 years old)
patient_sex:Not Specified
patient_information:Crohns disease
4:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Children (6 - 18 years old)
patient_sex:Not Specified
patient_information:Ulcerative colitis
5:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Children (6 - 18 years old)
patient_sex:Not Specified
patient_information:Unclassified IBD
疾病参考
1:
name:Febrile seizures
omim_id:604352
[1]:
reference_text:Rating D, Siemes H, Loscher W: Low CSF GABA concentration in children with febrile convulsions, untreated epilepsy, and meningitis. J Neurol. 1983;230(4):217-25.
pubmed_id:6198481
[2]:
reference_text:Rodriguez-Nunez A, Cid E, Rodriguez-Garcia J, Camina F, Rodriguez-Segade S, Castro-Gago M: Cerebrospinal fluid purine metabolite and neuron-specific enolase concentrations after febrile seizures. Brain Dev. 2000 Oct;22(7):427-31.
pubmed_id:11102727
[3]:
reference_text:Cotton MF, Donald PR, Aalbers C: Arginine vasopressin concentrations in the cerebrospinal fluid of children. Childs Nerv Syst. 1991 Nov;7(7):399-401.
pubmed_id:1794121
[4]:
reference_text:Hirai K, Seki T: Cerebrospinal fluid somatostatin levels in febrile seizures and epilepsy in children. Neuropeptides. 2000 Feb;34(1):18-24.
pubmed_id:10688964
2:
name:Crohn's disease
omim_id:266600
[1]:
reference_text:Lapidus A, Akerlund JE, Einarsson C: Gallbladder bile composition in patients with Crohn 's disease. World J Gastroenterol. 2006 Jan 7;12(1):70-4.
pubmed_id:16440420
[2]:
reference_text:Ehrenpreis ED, Salvino M, Craig RM: Improving the serum D-xylose test for the identification of patients with small intestinal malabsorption. J Clin Gastroenterol. 2001 Jul;33(1):36-40.
pubmed_id:11418788
[3]:
reference_text:Brydon WG, Nyhlin H, Eastwood MA, Merrick MV: Serum 7 alpha-hydroxy-4-cholesten-3-one and selenohomocholyltaurine (SeHCAT) whole body retention in the assessment of bile acid induced diarrhoea. Eur J Gastroenterol Hepatol. 1996 Feb;8(2):117-23.
pubmed_id:8723414
[4]:
reference_text:Williams HR, Cox IJ, Walker DG, North BV, Patel VM, Marshall SE, Jewell DP, Ghosh S, Thomas HJ, Teare JP, Jakobovits S, Zeki S, Welsh KI, Taylor-Robinson SD, Orchard TR: Characterization of inflammatory bowel disease with urinary metabolic profiling. Am J Gastroenterol. 2009 Jun;104(6):1435-44. doi: 10.1038/ajg.2009.175. Epub 2009 Apr 28.
pubmed_id:19491857
[5]:
reference_text:Marchesi JR, Holmes E, Khan F, Kochhar S, Scanlan P, Shanahan F, Wilson ID, Wang Y: Rapid and noninvasive metabonomic characterization of inflammatory bowel disease. J Proteome Res. 2007 Feb;6(2):546-51.
pubmed_id:17269711
[6]:
reference_text:Ahmed I, Greenwood R, Costello Bde L, Ratcliffe NM, Probert CS: An investigation of fecal volatile organic metabolites in irritable bowel syndrome. PLoS One. 2013;8(3):e58204. doi: 10.1371/journal.pone.0058204. Epub 2013 Mar 13.
pubmed_id:23516449
[7]:
reference_text:Walton C, Fowler DP, Turner C, Jia W, Whitehead RN, Griffiths L, Dawson C, Waring RH, Ramsden DB, Cole JA, Cauchi M, Bessant C, Hunter JO: Analysis of volatile organic compounds of bacterial origin in chronic gastrointestinal diseases. Inflamm Bowel Dis. 2013 Sep;19(10):2069-78. doi: 10.1097/MIB.0b013e31829a91f6.
pubmed_id:23867873
[8]:
reference_text:De Preter V, Machiels K, Joossens M, Arijs I, Matthys C, Vermeire S, Rutgeerts P, Verbeke K: Faecal metabolite profiling identifies medium-chain fatty acids as discriminating compounds in IBD. Gut. 2015 Mar;64(3):447-58. doi: 10.1136/gutjnl-2013-306423. Epub 2014 May 8.
pubmed_id:24811995
[9]:
reference_text:Bjerrum JT, Wang Y, Hao F, Coskun M, Ludwig C, Gunther U, Nielsen OH: Metabonomics of human fecal extracts characterize ulcerative colitis, Crohn's disease and healthy individuals. Metabolomics. 2015;11:122-133. Epub 2014 Jun 1.
pubmed_id:25598765
[10]:
reference_text:Ahmed I, Greenwood R, Costello B, Ratcliffe N, Probert CS: Investigation of faecal volatile organic metabolites as novel diagnostic biomarkers in inflammatory bowel disease. Aliment Pharmacol Ther. 2016 Mar;43(5):596-611. doi: 10.1111/apt.13522. Epub 2016 Jan 25.
pubmed_id:26806034
[11]:
reference_text:Lee T, Clavel T, Smirnov K, Schmidt A, Lagkouvardos I, Walker A, Lucio M, Michalke B, Schmitt-Kopplin P, Fedorak R, Haller D: Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD. Gut. 2017 May;66(5):863-871. doi: 10.1136/gutjnl-2015-309940. Epub 2016 Feb 4.
pubmed_id:26848182
[12]:
reference_text:Kolho KL, Pessia A, Jaakkola T, de Vos WM, Velagapudi V: Faecal and Serum Metabolomics in Paediatric Inflammatory Bowel Disease. J Crohns Colitis. 2017 Mar 1;11(3):321-334. doi: 10.1093/ecco-jcc/jjw158.
pubmed_id:27609529
[13]:
reference_text:Azario I, Pievani A, Del Priore F, Antolini L, Santi L, Corsi A, Cardinale L, Sawamoto K, Kubaski F, Gentner B, Bernardo ME, Valsecchi MG, Riminucci M, Tomatsu S, Aiuti A, Biondi A, Serafini M: Neonatal umbilical cord blood transplantation halts skeletal disease progression in the murine model of MPS-I. Sci Rep. 2017 Aug 25;7(1):9473. doi: 10.1038/s41598-017-09958-9.
pubmed_id:28842642
3:
name:Ulcerative colitis
omim_id:
[1]:
reference_text:Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. doi: 10.1093/nar/gkq1126. Epub 2010 Nov 8.
pubmed_id:21059682
[2]:
reference_text:Almer S, Andersson T, Strom M: Pharmacokinetics of tranexamic acid in patients with ulcerative colitis and in healthy volunteers after the single instillation of 2 g rectally. J Clin Pharmacol. 1992 Jan;32(1):49-54.
pubmed_id:1740537
[3]:
reference_text:Marchesi JR, Holmes E, Khan F, Kochhar S, Scanlan P, Shanahan F, Wilson ID, Wang Y: Rapid and noninvasive metabonomic characterization of inflammatory bowel disease. J Proteome Res. 2007 Feb;6(2):546-51.
pubmed_id:17269711
[4]:
reference_text:Garner CE, Smith S, de Lacy Costello B, White P, Spencer R, Probert CS, Ratcliffe NM: Volatile organic compounds from feces and their potential for diagnosis of gastrointestinal disease. FASEB J. 2007 Jun;21(8):1675-88. Epub 2007 Feb 21.
pubmed_id:17314143
[5]:
reference_text:Le Gall G, Noor SO, Ridgway K, Scovell L, Jamieson C, Johnson IT, Colquhoun IJ, Kemsley EK, Narbad A: Metabolomics of fecal extracts detects altered metabolic activity of gut microbiota in ulcerative colitis and irritable bowel syndrome. J Proteome Res. 2011 Sep 2;10(9):4208-18. doi: 10.1021/pr2003598. Epub 2011 Aug 8.
pubmed_id:21761941
[6]:
reference_text:Ahmed I, Greenwood R, Costello Bde L, Ratcliffe NM, Probert CS: An investigation of fecal volatile organic metabolites in irritable bowel syndrome. PLoS One. 2013;8(3):e58204. doi: 10.1371/journal.pone.0058204. Epub 2013 Mar 13.
pubmed_id:23516449
[7]:
reference_text:Walton C, Fowler DP, Turner C, Jia W, Whitehead RN, Griffiths L, Dawson C, Waring RH, Ramsden DB, Cole JA, Cauchi M, Bessant C, Hunter JO: Analysis of volatile organic compounds of bacterial origin in chronic gastrointestinal diseases. Inflamm Bowel Dis. 2013 Sep;19(10):2069-78. doi: 10.1097/MIB.0b013e31829a91f6.
pubmed_id:23867873
[8]:
reference_text:De Preter V, Machiels K, Joossens M, Arijs I, Matthys C, Vermeire S, Rutgeerts P, Verbeke K: Faecal metabolite profiling identifies medium-chain fatty acids as discriminating compounds in IBD. Gut. 2015 Mar;64(3):447-58. doi: 10.1136/gutjnl-2013-306423. Epub 2014 May 8.
pubmed_id:24811995
[9]:
reference_text:Bjerrum JT, Wang Y, Hao F, Coskun M, Ludwig C, Gunther U, Nielsen OH: Metabonomics of human fecal extracts characterize ulcerative colitis, Crohn's disease and healthy individuals. Metabolomics. 2015;11:122-133. Epub 2014 Jun 1.
pubmed_id:25598765
[10]:
reference_text:Ahmed I, Greenwood R, Costello B, Ratcliffe N, Probert CS: Investigation of faecal volatile organic metabolites as novel diagnostic biomarkers in inflammatory bowel disease. Aliment Pharmacol Ther. 2016 Mar;43(5):596-611. doi: 10.1111/apt.13522. Epub 2016 Jan 25.
pubmed_id:26806034
[11]:
reference_text:Lee T, Clavel T, Smirnov K, Schmidt A, Lagkouvardos I, Walker A, Lucio M, Michalke B, Schmitt-Kopplin P, Fedorak R, Haller D: Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD. Gut. 2017 May;66(5):863-871. doi: 10.1136/gutjnl-2015-309940. Epub 2016 Feb 4.
pubmed_id:26848182
[12]:
reference_text:Kolho KL, Pessia A, Jaakkola T, de Vos WM, Velagapudi V: Faecal and Serum Metabolomics in Paediatric Inflammatory Bowel Disease. J Crohns Colitis. 2017 Mar 1;11(3):321-334. doi: 10.1093/ecco-jcc/jjw158.
pubmed_id:27609529
[13]:
reference_text:Azario I, Pievani A, Del Priore F, Antolini L, Santi L, Corsi A, Cardinale L, Sawamoto K, Kubaski F, Gentner B, Bernardo ME, Valsecchi MG, Riminucci M, Tomatsu S, Aiuti A, Biondi A, Serafini M: Neonatal umbilical cord blood transplantation halts skeletal disease progression in the murine model of MPS-I. Sci Rep. 2017 Aug 25;7(1):9473. doi: 10.1038/s41598-017-09958-9.
pubmed_id:28842642
综合参考
Park, Yeong Hun; Cho, Gwang Myeong; Baek, Min Ji; Hong, Guk Gi; Lee, Jin Nam. Method for preparing 5'-inosinic acid by using microbe capable of over-expressing purC gene. Repub. Korea (2007), 7pp.
一般参考
1:
protein_accession:HMDBP00001
name:5'-nucleotidase
uniprot_id:P21589
gene_name:NT5E
protein_type:Unknown
2:
protein_accession:HMDBP00004
name:Cytosolic 5'-nucleotidase 1B
uniprot_id:Q96P26
gene_name:NT5C1B
protein_type:Unknown
3:
protein_accession:HMDBP00005
name:Cytosolic 5'-nucleotidase 1A
uniprot_id:Q9BXI3
gene_name:NT5C1A
protein_type:Unknown
4:
protein_accession:HMDBP00006
name:5'(3')-deoxyribonucleotidase, cytosolic type
uniprot_id:Q8TCD5
gene_name:NT5C
protein_type:Unknown
5:
protein_accession:HMDBP00008
name:5'(3')-deoxyribonucleotidase, mitochondrial
uniprot_id:Q9NPB1
gene_name:NT5M
protein_type:Unknown
6:
protein_accession:HMDBP00084
name:Ectonucleoside triphosphate diphosphohydrolase 1
uniprot_id:P49961
gene_name:ENTPD1
protein_type:Unknown
7:
protein_accession:HMDBP00085
name:Soluble calcium-activated nucleotidase 1
uniprot_id:Q8WVQ1
gene_name:CANT1
protein_type:Unknown
8:
protein_accession:HMDBP00086
name:Ectonucleoside triphosphate diphosphohydrolase 3
uniprot_id:O75355
gene_name:ENTPD3
protein_type:Unknown
9:
protein_accession:HMDBP00370
name:Glycogen phosphorylase, liver form
uniprot_id:P06737
gene_name:PYGL
protein_type:Enzyme
10:
protein_accession:HMDBP00373
name:Glycogen phosphorylase, muscle form
uniprot_id:P11217
gene_name:PYGM
protein_type:Enzyme
11:
protein_accession:HMDBP00375
name:Glycogen phosphorylase, brain form
uniprot_id:P11216
gene_name:PYGB
protein_type:Enzyme
12:
protein_accession:HMDBP00431
name:Inosine triphosphate pyrophosphatase
uniprot_id:Q9BY32
gene_name:ITPA
protein_type:Unknown
13:
protein_accession:HMDBP00475
name:Hypoxanthine-guanine phosphoribosyltransferase
uniprot_id:P00492
gene_name:HPRT1
protein_type:Unknown
14:
protein_accession:HMDBP00597
name:AMP deaminase 3
uniprot_id:Q01432
gene_name:AMPD3
protein_type:Enzyme
15:
protein_accession:HMDBP00599
name:AMP deaminase 2
uniprot_id:Q01433
gene_name:AMPD2
protein_type:Enzyme
16:
protein_accession:HMDBP00657
name:AMP deaminase 1
uniprot_id:P23109
gene_name:AMPD1
protein_type:Enzyme
17:
protein_accession:HMDBP00678
name:GMP reductase 2
uniprot_id:Q9P2T1
gene_name:GMPR2
protein_type:Enzyme
18:
protein_accession:HMDBP00685
name:GMP reductase 1
uniprot_id:P36959
gene_name:GMPR
protein_type:Enzyme
19:
protein_accession:HMDBP00877
name:Ectonucleoside triphosphate diphosphohydrolase 4
uniprot_id:Q9Y227
gene_name:ENTPD4
protein_type:Unknown
20:
protein_accession:HMDBP00878
name:Ectonucleoside triphosphate diphosphohydrolase 6
uniprot_id:O75354
gene_name:ENTPD6
protein_type:Unknown
21:
protein_accession:HMDBP00879
name:Ectonucleoside triphosphate diphosphohydrolase 5
uniprot_id:O75356
gene_name:ENTPD5
protein_type:Unknown
22:
protein_accession:HMDBP00880
name:Adenylosuccinate synthetase isozyme 2
uniprot_id:P30520
gene_name:ADSS
protein_type:Unknown
23:
protein_accession:HMDBP00881
name:Inosine-5'-monophosphate dehydrogenase 2
uniprot_id:P12268
gene_name:IMPDH2
protein_type:Unknown
24:
protein_accession:HMDBP00882
name:Bifunctional purine biosynthesis protein PURH
uniprot_id:P31939
gene_name:ATIC
protein_type:Enzyme
25:
protein_accession:HMDBP00883
name:Inosine-5'-monophosphate dehydrogenase 1
uniprot_id:P20839
gene_name:IMPDH1
protein_type:Unknown
26:
protein_accession:HMDBP00884
name:Adenylosuccinate synthetase isozyme 1
uniprot_id:Q8N142
gene_name:ADSSL1
protein_type:Unknown
27:
protein_accession:HMDBP03189
name:Cytosolic 5'-nucleotidase 3
uniprot_id:Q9H0P0
gene_name:NT5C3
protein_type:Enzyme
28:
protein_accession:HMDBP03208
name:ENTPD4 protein
uniprot_id:Q8NE73
gene_name:ENTPD4
protein_type:Enzyme
29:
protein_accession:HMDBP03750
name:Cytosolic purine 5'-nucleotidase
uniprot_id:P49902
gene_name:NT5C2
protein_type:Unknown
30:
protein_accession:HMDBP07408
name:Inosine-5'-monophosphate dehydrogenase
uniprot_id:A4D0Z6
gene_name:IMPDH1
protein_type:Enzyme
31:
protein_accession:HMDBP07670
name:Ectonucleoside triphosphate diphosphohydrolase 8
uniprot_id:Q5MY95
gene_name:ENTPD8
protein_type:Unknown
蛋白质结合
1:
reference_text:Nakayama Y, Kinoshita A, Tomita M: Dynamic simulation of red blood cell metabolism and its application to the analysis of a pathological condition. Theor Biol Med Model. 2005 May 9;2:18.
pubmed_id:15882454
2:
reference_text:McConell GK, Shinewell J, Stephens TJ, Stathis CG, Canny BJ, Snow RJ: Creatine supplementation reduces muscle inosine monophosphate during endurance exercise in humans. Med Sci Sports Exerc. 2005 Dec;37(12):2054-61.
pubmed_id:16331129
3:
reference_text:Castro-Gago M, Cid E, Trabazo S, Pavon P, Camina F, Rodriguez-Segade S, Einis Punal J, Rodriguez-Nunez A: Cerebrospinal fluid purine metabolites and pyrimidine bases after brief febrile convulsions. Epilepsia. 1995 May;36(5):471-4.
pubmed_id:7614924
4:
reference_text:Green HJ, Grant SM, Phillips SM, Enns DL, Tarnopolsky MA, Sutton JR: Reduced muscle lactate during prolonged exercise following induced plasma volume expansion. Can J Physiol Pharmacol. 1997 Dec;75(12):1280-6.
pubmed_id:9534937
5:
reference_text:Rodriguez-Nunez A, Cid E, Rodriguez-Garcia J, Camina F, Rodriguez-Segade S, Castro-Gago M: Concentrations of nucleotides, nucleosides, purine bases, oxypurines, uric acid, and neuron-specific enolase in the cerebrospinal fluid of children with sepsis. J Child Neurol. 2001 Sep;16(9):704-6.
pubmed_id:11575617
6:
reference_text:Pouw EM, Schols AM, van der Vusse GJ, Wouters EF: Elevated inosine monophosphate levels in resting muscle of patients with stable chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998 Feb;157(2):453-7.
pubmed_id:9476857
7:
reference_text:Allison AC, Eugui EM: Purine metabolism and immunosuppressive effects of mycophenolate mofetil (MMF). Clin Transplant. 1996 Feb;10(1 Pt 2):77-84.
pubmed_id:8680053
8:
reference_text:van Hall G, van der Vusse GJ, Soderlund K, Wagenmakers AJ: Deamination of amino acids as a source for ammonia production in human skeletal muscle during prolonged exercise. J Physiol. 1995 Nov 15;489 ( Pt 1):251-61.
pubmed_id:8583409
9:
reference_text:McConell G, Snow RJ, Proietto J, Hargreaves M: Muscle metabolism during prolonged exercise in humans: influence of carbohydrate availability. J Appl Physiol (1985). 1999 Sep;87(3):1083-6.
pubmed_id:10484580
10:
reference_text:Klupp J, Pfitzmann R, Langrehr JM, Neuhaus P: Indications of mycophenolate mofetil in liver transplantation. Transplantation. 2005 Sep 27;80(1 Suppl):S142-6.
pubmed_id:16286893
11:
reference_text:Bangsbo J, Gollnick PD, Graham TE, Juel C, Kiens B, Mizuno M, Saltin B: Anaerobic energy production and O2 deficit-debt relationship during exhaustive exercise in humans. J Physiol. 1990 Mar;422:539-59.
pubmed_id:2352192
12:
reference_text:McCauley TG, Hamaguchi N, Stanton M: Aptamer-based biosensor arrays for detection and quantification of biological macromolecules. Anal Biochem. 2003 Aug 15;319(2):244-50.
pubmed_id:12871718
13:
reference_text:Rush JW, MacLean DA, Hultman E, Graham TE: Exercise causes branched-chain oxoacid dehydrogenase dephosphorylation but not AMP deaminase binding. J Appl Physiol (1985). 1995 Jun;78(6):2193-200.
pubmed_id:7665417
14:
reference_text:McConell GK, Canny BJ, Daddo MC, Nance MJ, Snow RJ: Effect of carbohydrate ingestion on glucose kinetics and muscle metabolism during intense endurance exercise. J Appl Physiol (1985). 2000 Nov;89(5):1690-8.
pubmed_id:11053315
15:
reference_text:Swart PJ, Beljaars E, Smit C, Pasma A, Schuitemaker H, Meijer DK: Comparative pharmacokinetic, immunologic and hematologic studies on the anti-HIV-1/2 compounds aconitylated and succinylated HSA. J Drug Target. 1996;4(2):109-16.
pubmed_id:8894971
16:
reference_text:Scott GS, Spitsin SV, Kean RB, Mikheeva T, Koprowski H, Hooper DC: Therapeutic intervention in experimental allergic encephalomyelitis by administration of uric acid precursors. Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16303-8. Epub 2002 Nov 25.
pubmed_id:12451183