版本
5.0
创建日期
2005-11-16 15:48:42 UTC
更新日期
2021-09-14 15:45:02 UTC
登录号
HMDB0000172
地位
quantified
二级访问
HMDB00172

名称
L-Isoleucine
描述
Isoleucine (Ile) or L-isoleucine is an alpha-amino acid. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). Amino acids are organic compounds that contain amino (–NH2) and carboxyl (–COOH) functional groups, along with a side chain (R group) specific to each amino acid. L-isolecuine is one of 20 proteinogenic amino acids, i.e., the amino acids used in the biosynthesis of proteins. Isoleucine is found in all organisms ranging from bacteria to plants to animals. It is classified as a non-polar, uncharged (at physiological pH) aliphatic amino acid. Isoleucine is an essential amino acid in humans, meaning the body cannot synthesize it and that it must be obtained from the diet. In plants and microorganisms, isoleucine is synthesized starting from pyruvate and alpha-ketobutyrate. Isoleucine is classified as a branched chain amino acid (BCAA). BCAAs include three amino acids: isoleucine, leucine and valine. They are alpha amino acids whose carbon structure is marked by a beta branch point. Despite their structural similarities, BCAAs have different metabolic routes, with valine going solely to carbohydrates (glucogenic), leucine solely to fats (ketogenic) and isoleucine being both a glucogenic and a ketogenic amino acid. Isoleucine is catabolized via with alpha-ketoglutarate where upon it is oxidized and split into propionyl-CoA and acetyl-CoA. Propionyl-CoA is converted into succinyl-CoA, a TCA cycle intermediate which can be converted into oxaloacetate for gluconeogenesis (hence glucogenic). The acetyl-CoA can be fed into the TCA cycle by condensing with oxaloacetate to form citrate or used in the synthesis of ketone bodies or fatty acids. The different metabolism of BCAAs accounts for different requirements for these essential amino acids in humans: 12 mg/kg, 14 mg/kg and 16 mg/kg of valine, leucine and isoleucine are required respectively. Furthermore, these amino acids have different deficiency symptoms. Valine deficiency is marked by neurological defects in the brain, while isoleucine deficiency is marked by muscle tremors. BCAAs are decreased in patients with liver disease, such as hepatitis, hepatic coma, cirrhosis, extrahepatic biliary atresia. An inability to break down isoleucine, along with other amino acids, is associated with maple syrup urine disease (MSUD) (PMID: 34125801). Isoleucine, like other BCAAs, is associated with insulin resistance. In particular, higher levels of isoleucine are observed in the blood of diabetic mice, rats, and humans (PMID 25287287). Mice fed an isoleucine deprivation diet for one day have improved insulin sensitivity, and feeding of an isoleucine deprivation diet for one week significantly decreases blood glucose levels (PMID: 24684822).
同义词
1:(2S,3S)-2-Amino-3-methylpentanoic acid

2:2-Amino-3-methylvaleric acid

3:alpha-Amino-beta-methylvaleric acid

4:I

5:Ile

6:ISOLEUCINE

7:(2S,3S)-2-Amino-3-methylpentanoate

8:2-Amino-3-methylvalerate

9:a-Amino-b-methylvalerate

10:a-Amino-b-methylvaleric acid

11:alpha-Amino-beta-methylvalerate

12:Α-amino-β-methylvalerate

13:Α-amino-β-methylvaleric acid

14:(2S,3S)-2-Amino-3-methyl-pentanoate

15:(2S,3S)-2-Amino-3-methyl-pentanoic acid

16:(2S,3S)-a-Amino-b-methyl-N-valerate

17:(2S,3S)-a-Amino-b-methyl-N-valeric acid

18:(2S,3S)-a-Amino-b-methylvalerate

19:(2S,3S)-a-Amino-b-methylvaleric acid

20:(2S,3S)-Alph-amino-beta-methylvalerate

21:(2S,3S)-Alph-amino-beta-methylvaleric acid

22:(2S,3S)-alpha-Amino-beta-merthyl-N-valerate

23:(2S,3S)-alpha-Amino-beta-merthyl-N-valeric acid

24:(2S,3S)-alpha-Amino-beta-merthylvalerate

25:(2S,3S)-alpha-Amino-beta-merthylvaleric acid

26:(2S,3S)-alpha-Amino-beta-methyl-N-valerate

27:(2S,3S)-alpha-Amino-beta-methyl-N-valeric acid

28:(2S,3S)-alpha-Amino-beta-methylvalerate

29:(2S,3S)-alpha-Amino-beta-methylvaleric acid

30:(S)-Isoleucine

31:(S,S)-Isoleucine

32:2-Amino-3-methylpentanoate

33:2-Amino-3-methylpentanoic acid

34:2S,3S-Isoleucine

35:Erythro-L-isoleucine

36:Iso-leucine

37:L-(+)-Isoleucine

38:L-Ile

39:[S-(R*,r*)]-2-amino-3-methylpentanoate

40:[S-(R*,r*)]-2-amino-3-methylpentanoic acid

41:Isoleucine, L-isomer

42:Alloisoleucine

43:Isoleucine, L isomer

44:L-Isomer isoleucine

45:2S-Amino-3S-methylpentanoate

46:L-Isoleucine

化学式
C6H13NO2
平均分子量
131.1729
等位分子量
131.094628665
化学名称
(2S,3S)-2-amino-3-methylpentanoic acid
传统名称
L-isoleucine
CAS 登记号
73-32-5
代谢物结构字符串
CC[C@H](C)[C@H](N)C(O)=O
inchi标识符
InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1
印记键
AGPKZVBTJJNPAG-WHFBIAKZSA-N
分类学
description: belongs to the class of organic compounds known as isoleucine and derivatives. Isoleucine and derivatives are compounds containing isoleucine or a derivative thereof resulting from reaction of isoleucine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.

description:Isoleucine and derivatives

kingdom:Organic compounds

super_class:Organic acids and derivatives

class:Carboxylic acids and derivatives

sub_class:Amino acids, peptides, and analogues

molecular_framework:Aliphatic acyclic compounds

1:Amino acids

2:Carbonyl compounds

3:Carboxylic acids

4:Hydrocarbon derivatives

5:L-alpha-amino acids

6:Methyl-branched fatty acids

7:Monoalkylamines

8:Monocarboxylic acids and derivatives

9:Organic oxides

10:Organopnictogen compounds

11:Aliphatic acyclic compound

12:Alpha-amino acid

13:Amine

14:Amino acid

15:Branched fatty acid

16:Carbonyl group

17:Carboxylic acid

18:Fatty acid

19:Fatty acyl

20:Hydrocarbon derivative

21:Isoleucine or derivatives

22:L-alpha-amino acid

23:Methyl-branched fatty acid

24:Monocarboxylic acid or derivatives

25:Organic nitrogen compound

26:Organic oxide

27:Organic oxygen compound

28:Organonitrogen compound

29:Organooxygen compound

30:Organopnictogen compound

31:Primary aliphatic amine

32:Primary amine

33:Amino fatty acids

34:Common amino acids

35:L-alpha-amino acid

36:aspartate family amino acid

37:isoleucine

38:proteinogenic amino acid

本体论
term:Physiological effect

definition:The effect on an organism physiology, resulting from its exposure to a chemical.

parent_id:

level:1

type:parent

term:Health effect

definition:A health condition or observation associated with a stimuli or with a biological activity of a chemical.

parent_id:7693

*level:2

type:parent

term:Observation

definition:A short term health effect which reflects the reponse of the body to stimuli or is a symptom of a disease or condition; also includes health status which reflects stage in life.

parent_id:7694

**level:3

type:parent

term:Attachment loss

definition:

parent_id:7717

***level:4

type:child

term:Missing teeth

definition:

parent_id:7717

***level:4

type:child

term:Periodontal Probing Depth

definition:

parent_id:7717

***level:4

type:child

term:Health condition

definition:A health effect that consists on short or long-term disease, condition, disorder, syndrome or constant abnormality.

parent_id:7694

**level:3

type:parent

term:Epilepsy

definition:A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions. (do).

parent_id:7695

***level:4

type:child

synonym:Epileptic spasms

term:Schizophrenia

definition:A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness. (do).

parent_id:7695

***level:4

type:child

term:Cardiac disorders

definition:Any disorder that affects the heart.

parent_id:7695

***level:4

type:parent

term:Cancer

definition:A group of disorders characterized by the presense of malignant neoplasm.

parent_id:7695

***level:4

type:parent

term:Disposition

definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.

parent_id:

level:1

type:parent

term:Route of exposure

definition:A mean by which a chemical agent comes in contact with an organism, either under intended or unintended circumstances.

parent_id:7724

*level:2

type:parent

term:Enteral

definition:Chemical exposure via the alimentary canal (mouth to anus).

parent_id:7743

**level:3

type:parent

term:Ingestion

definition:Chemical exposure facilitated by entry through the mouth.

parent_id:7744

***level:4

type:child

synonym:Digestion

term:Source

definition:Natural or synthetic origin of a chemical.

parent_id:7724

*level:2

type:parent

term:Food

definition:

parent_id:7735

**level:3

type:child

term:Synthetic

definition:A man-made product or sample in which a chemical can be found.

parent_id:7735

**level:3

type:parent

term:Personal care product

definition:

parent_id:7742

***level:4

type:child

synonym:Pcp

synonym:Toiletries

synonym:Toiletry

synonym:Personal hygiene

synonym:Beautification product

term:Biological

definition:A living organism (species or a higher taxonomy rank), in which a chemical can be found.

parent_id:7735

**level:3

type:parent

term:Animal

definition:A living organism belonging to the kingdom animalia. it feeds on organic matter, typically having specialized sense organs and nervous system and able to respond rapidly to stimuli.

parent_id:7736

***level:4

type:child

synonym:Fauna

term:Plant

definition:A living organism belonging to the kingdom plantea. typically, it grows in a permanent site, absorbs water and inorganic substances through its roots, and synthesizes nutrients in its leaves by photosynthesis using the green pigment chlorophyll. examples incude trees, shrubs, herbs, grasses, ferns, and mosses.

parent_id:7736

***level:4

type:parent

synonym:Flora

term:Biological location

definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.

parent_id:7724

*level:2

type:parent

term:Tissue and substructures

definition:An anatomical organizational level including multiple cells yet not comprising a complete organ .

parent_id:7725

**level:3

type:parent

term:All tissues

definition:All tissues in the body of the organism.

parent_id:7729

***level:4

type:child

term:Placenta

definition:An organ present in some vertebrates during embryonic gestation that surrounds the fetus and provides it with nutrients and oxygen, facilitates gas and waste exchange between the fetus and mother, and provides parasitic cloaking from the mother's immune system by excretion of neurokinin b. (nci).

parent_id:7729

***level:4

type:child

term:Organ and components

definition:An anatomical organizational level including multiple tissues or substructures, which enables a common biological function.

parent_id:7725

**level:3

type:parent

term:Prostate

definition:The male reproductive accessory gland that produces prostatic fluid and is located adjacent to or around the urethra distal to the urinary bladder in mammals. (nci).

parent_id:7727

***level:4

type:child

synonym:Prostate gland

term:Biofluid and excreta

definition:A liquid, semi-solid or solid material originating in the body.

parent_id:7725

**level:3

type:parent

term:Urine

definition:Excretion in liquid state processed by the kidney.

parent_id:7731

***level:4

type:child

term:Saliva

definition:The watery fluid in the mouth made by the salivary glands. saliva moistens food to help digestion and it helps protect the mouth against infections. (nci).

parent_id:7731

***level:4

type:child

term:Feces

definition:The material discharged from the bowel during defecation. It consists of undigested food, intestinal mucus, epithelial cells, and bacteria.

parent_id:7731

***level:4

type:child

synonym:Fecal

synonym:Stool

synonym:Faecal

synonym:Faeces

term:Blood

definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.

parent_id:7731

***level:4

type:child

term:Breast milk

definition:Portion of secreted substance produced by the mammary gland.

parent_id:7731

***level:4

type:child

term:Sweat

definition:Secretion produced by a sweat gland.

parent_id:7731

***level:4

type:child

term:Cerebrospinal fluid

definition:The fluid that is contained within the brain ventricles, the subarachnoid space and the central canal of the spinal cord. (nci).

parent_id:7731

***level:4

type:child

synonym:Csf

term:Subcellular

definition:An anatomical organizational level including a component within a biological cell .

parent_id:7725

**level:3

type:parent

term:Cytoplasm

definition:The portion of the cell contained within the plasma membrane but excluding the nucleus.

parent_id:7730

***level:4

type:child

synonym:Cytoplasma

term:Mitochondria

definition:

parent_id:7730

***level:4

type:child

term:Cell and elements

definition:An anatomical organizational level comprising of a single cell (or a fragment in some exceptions). a cell is defined by its type or function. it is the smallest unit of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid.

parent_id:7725

**level:3

type:parent

term:Extracellular

definition:The space external to the outermost structure of a cell.

parent_id:7732

***level:4

type:child

synonym:Extracellular region

term:Process

definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.

parent_id:

level:1

type:parent

term:Naturally occurring process

definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.

parent_id:7659

*level:2

type:parent

term:Biological process

definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.

parent_id:7660

**level:3

type:parent

term:Biochemical pathway

definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.

parent_id:7661

***level:4

type:parent

term:Role

definition:The purpose or function assumed by a chemical, either naturally or as intended by humans .

parent_id:

level:1

type:parent

term:Industrial application

definition:The assumed function of a chemical utilized by human.

parent_id:7671

*level:2

type:parent

term:Drug

definition:A chemical substance or preparation that causes a physiological effect in the body upon exposure .

parent_id:7678

**level:3

type:child

term:Food and nutrition

definition:A chemical purpose related to manufacturing of food and nutrition products.

parent_id:7678

**level:3

type:child

term:Personal care products

definition:Cosmetics and personal hygene products in which a chemical was incorportaed during the manufacturing process.

parent_id:7678

**level:3

type:child

term:Pharmaceutical industry

definition:A pharmacologic activity for which a chemical substance is utilized owing to its biological role.

parent_id:7678

**level:3

type:parent

term:Pharmaceutical

definition:

parent_id:7679

***level:4

type:child

term:Biological role

definition:The biological function of a chemical. the biological role answers the question how a chemical is involved in molecular processes in an organism. this can include biochemical effects of non-endogenous chemicals, which are also assigned an industrial application such as pharmaceuticals. the biological role is limited to cellular levls, and will not include role at system process level, such as a chemical which has a role in a disease.

parent_id:7671

*level:2

type:parent

term:Essential amino acid

definition:

parent_id:7672

**level:3

type:child

状态
Solid
实验性质
1:

kind:water_solubility

value:35 mg/mL

source:Human Metabolome Project

2:

kind:logp

value:-1.70

source:HANSCH,C ET AL. (1995)

3:

kind:melting_point

value:285.5 °C

source:

预测性质
1:

kind:logp

value:-1.73

source:ALOGPS

2:

kind:logs

value:-0.06

source:ALOGPS

3:

kind:solubility

value:114 g/L

source:ALOGPS

4:

kind:logp

value:-1.5

source:ChemAxon

5:

kind:pka_strongest_acidic

value:2.79

source:ChemAxon

6:

kind:pka_strongest_basic

value:9.59

source:ChemAxon

7:

kind:iupac

value:(2S,3S)-2-amino-3-methylpentanoic acid

source:ChemAxon

8:

kind:average_mass

value:131.1729

source:ChemAxon

9:

kind:mono_mass

value:131.094628665

source:ChemAxon

10:

kind:smiles

value:CC[C@H](C)[C@H](N)C(O)=O

source:ChemAxon

11:

kind:formula

value:C6H13NO2

source:ChemAxon

12:

kind:inchi

value:InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1

source:ChemAxon

13:

kind:inchikey

value:AGPKZVBTJJNPAG-WHFBIAKZSA-N

source:ChemAxon

14:

kind:polar_surface_area

value:63.32

source:ChemAxon

15:

kind:refractivity

value:34.09

source:ChemAxon

16:

kind:polarizability

value:14.11

source:ChemAxon

17:

kind:rotatable_bond_count

value:3

source:ChemAxon

18:

kind:acceptor_count

value:3

source:ChemAxon

19:

kind:donor_count

value:2

source:ChemAxon

20:

kind:physiological_charge

value:0

source:ChemAxon

21:

kind:formal_charge

value:0

source:ChemAxon

22:

kind:number_of_rings

value:0

source:ChemAxon

23:

kind:bioavailability

value:Yes

source:ChemAxon

24:

kind:rule_of_five

value:Yes

source:ChemAxon

25:

kind:ghose_filter

value:No

source:ChemAxon

26:

kind:veber_rule

value:No

source:ChemAxon

27:

kind:mddr_like_rule

value:No

source:ChemAxon

1:

type:Specdb::NmrTwoD

spectrum_id:981

2:

type:Specdb::NmrTwoD

spectrum_id:1185

3:

type:Specdb::EiMs

spectrum_id:1294

4:

type:Specdb::CMs

spectrum_id:410

5:

type:Specdb::CMs

spectrum_id:411

6:

type:Specdb::CMs

spectrum_id:412

7:

type:Specdb::CMs

spectrum_id:413

8:

type:Specdb::CMs

spectrum_id:414

9:

type:Specdb::CMs

spectrum_id:2741

10:

type:Specdb::CMs

spectrum_id:30031

11:

type:Specdb::CMs

spectrum_id:30374

12:

type:Specdb::CMs

spectrum_id:30375

13:

type:Specdb::CMs

spectrum_id:30376

14:

type:Specdb::CMs

spectrum_id:30599

15:

type:Specdb::CMs

spectrum_id:30727

16:

type:Specdb::CMs

spectrum_id:30793

17:

type:Specdb::CMs

spectrum_id:32117

18:

type:Specdb::CMs

spectrum_id:32316

19:

type:Specdb::CMs

spectrum_id:37336

20:

type:Specdb::CMs

spectrum_id:154007

21:

type:Specdb::NmrOneD

spectrum_id:1136

22:

type:Specdb::NmrOneD

spectrum_id:1189

23:

type:Specdb::NmrOneD

spectrum_id:3304

24:

type:Specdb::NmrOneD

spectrum_id:5972

25:

type:Specdb::NmrOneD

spectrum_id:5973

26:

type:Specdb::NmrOneD

spectrum_id:5974

27:

type:Specdb::NmrOneD

spectrum_id:5975

28:

type:Specdb::NmrOneD

spectrum_id:5976

29:

type:Specdb::NmrOneD

spectrum_id:5977

30:

type:Specdb::NmrOneD

spectrum_id:5978

31:

type:Specdb::NmrOneD

spectrum_id:5979

32:

type:Specdb::NmrOneD

spectrum_id:5980

33:

type:Specdb::NmrOneD

spectrum_id:5981

34:

type:Specdb::NmrOneD

spectrum_id:5982

35:

type:Specdb::NmrOneD

spectrum_id:5983

36:

type:Specdb::NmrOneD

spectrum_id:5984

37:

type:Specdb::NmrOneD

spectrum_id:5985

38:

type:Specdb::NmrOneD

spectrum_id:5986

39:

type:Specdb::NmrOneD

spectrum_id:5987

40:

type:Specdb::NmrOneD

spectrum_id:5988

41:

type:Specdb::NmrOneD

spectrum_id:5989

42:

type:Specdb::NmrOneD

spectrum_id:5990

43:

type:Specdb::NmrOneD

spectrum_id:5991

44:

type:Specdb::NmrOneD

spectrum_id:166474

45:

type:Specdb::MsMs

spectrum_id:3325

46:

type:Specdb::MsMs

spectrum_id:3326

47:

type:Specdb::MsMs

spectrum_id:3327

48:

type:Specdb::MsMs

spectrum_id:3328

49:

type:Specdb::MsMs

spectrum_id:3329

50:

type:Specdb::MsMs

spectrum_id:437940

51:

type:Specdb::MsMs

spectrum_id:437941

52:

type:Specdb::MsMs

spectrum_id:437942

53:

type:Specdb::MsMs

spectrum_id:437943

54:

type:Specdb::MsMs

spectrum_id:437944

55:

type:Specdb::MsMs

spectrum_id:2244023

56:

type:Specdb::MsMs

spectrum_id:2244086

57:

type:Specdb::MsMs

spectrum_id:2245987

58:

type:Specdb::MsMs

spectrum_id:2246039

59:

type:Specdb::MsMs

spectrum_id:2248163

60:

type:Specdb::MsMs

spectrum_id:2248242

61:

type:Specdb::MsMs

spectrum_id:2250311

62:

type:Specdb::MsMs

spectrum_id:2252105

63:

type:Specdb::MsMs

spectrum_id:271

64:

type:Specdb::MsMs

spectrum_id:272

65:

type:Specdb::MsMs

spectrum_id:273

66:

type:Specdb::MsMs

spectrum_id:3317

67:

type:Specdb::MsMs

spectrum_id:3318

68:

type:Specdb::MsMs

spectrum_id:3319

69:

type:Specdb::MsMs

spectrum_id:3320

光谱
生物学性质
1:

cellular:(1):Cytoplasm

cellular:(2):Extracellular

cellular:(3):Mitochondria

2:

biospecimen:(1):Blood

biospecimen:(2):Breast Milk

biospecimen:(3):Cerebrospinal Fluid (CSF)

biospecimen:(4):Feces

biospecimen:(5):Saliva

biospecimen:(6):Sweat

biospecimen:(7):Urine

3:

tissue:(1):All Tissues

tissue:(2):Placenta

tissue:(3):Prostate

4:

[1]:

name:2-Methyl-3-Hydroxybutryl CoA Dehydrogenase Deficiency

smpdb_id:SMP00137

kegg_map_id:

[2]:

name:3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency

smpdb_id:SMP00138

kegg_map_id:

[3]:

name:3-hydroxyisobutyric acid dehydrogenase deficiency

smpdb_id:SMP00521

kegg_map_id:

[4]:

name:3-hydroxyisobutyric aciduria

smpdb_id:SMP00522

kegg_map_id:

[5]:

name:3-Methylcrotonyl Coa Carboxylase Deficiency Type I

smpdb_id:SMP00237

kegg_map_id:

[6]:

name:3-Methylglutaconic Aciduria Type I

smpdb_id:SMP00139

kegg_map_id:

[7]:

name:3-Methylglutaconic Aciduria Type III

smpdb_id:SMP00140

kegg_map_id:

[8]:

name:3-Methylglutaconic Aciduria Type IV

smpdb_id:SMP00141

kegg_map_id:

[9]:

name:Amikacin Action Pathway

smpdb_id:SMP00253

kegg_map_id:

[10]:

name:Arbekacin Action Pathway

smpdb_id:SMP00713

kegg_map_id:

[11]:

name:Azithromycin Action Pathway

smpdb_id:SMP00247

kegg_map_id:

[12]:

name:Beta-Ketothiolase Deficiency

smpdb_id:SMP00173

kegg_map_id:

[13]:

name:Chloramphenicol Action Pathway

smpdb_id:SMP00729

kegg_map_id:

[14]:

name:Clarithromycin Action Pathway

smpdb_id:SMP00248

kegg_map_id:

[15]:

name:Clindamycin Action Pathway

smpdb_id:SMP00249

kegg_map_id:

[16]:

name:Clomocycline Action Pathway

smpdb_id:SMP00262

kegg_map_id:

[17]:

name:Demeclocycline Action Pathway

smpdb_id:SMP00290

kegg_map_id:

[18]:

name:Doxycycline Action Pathway

smpdb_id:SMP00291

kegg_map_id:

[19]:

name:Erythromycin Action Pathway

smpdb_id:SMP00250

kegg_map_id:

[20]:

name:Gentamicin Action Pathway

smpdb_id:SMP00254

kegg_map_id:

[21]:

name:Isobutyryl-coa dehydrogenase deficiency

smpdb_id:SMP00523

kegg_map_id:

[22]:

name:Isovaleric acidemia

smpdb_id:SMP00524

kegg_map_id:

[23]:

name:Isovaleric Aciduria

smpdb_id:SMP00238

kegg_map_id:

[24]:

name:Josamycin Action Pathway

smpdb_id:SMP00731

kegg_map_id:

[25]:

name:Kanamycin Action Pathway

smpdb_id:SMP00255

kegg_map_id:

[26]:

name:Lincomycin Action Pathway

smpdb_id:SMP00728

kegg_map_id:

[27]:

name:Lymecycline Action Pathway

smpdb_id:SMP00295

kegg_map_id:

[28]:

name:Maple Syrup Urine Disease

smpdb_id:SMP00199

kegg_map_id:

[29]:

name:Methacycline Action Pathway

smpdb_id:SMP00727

kegg_map_id:

[30]:

name:Methylmalonate Semialdehyde Dehydrogenase Deficiency

smpdb_id:SMP00384

kegg_map_id:

[31]:

name:Methylmalonic Aciduria

smpdb_id:SMP00200

kegg_map_id:

[32]:

name:Minocycline Action Pathway

smpdb_id:SMP00292

kegg_map_id:

[33]:

name:Neomycin Action Pathway

smpdb_id:SMP00256

kegg_map_id:

[34]:

name:Netilmicin Action Pathway

smpdb_id:SMP00257

kegg_map_id:

[35]:

name:Oxytetracycline Action Pathway

smpdb_id:SMP00293

kegg_map_id:

[36]:

name:Paromomycin Action Pathway

smpdb_id:SMP00714

kegg_map_id:

[37]:

name:Propionic Acidemia

smpdb_id:SMP00236

kegg_map_id:

[38]:

name:Rolitetracycline Action Pathway

smpdb_id:SMP00726

kegg_map_id:

[39]:

name:Roxithromycin Action Pathway

smpdb_id:SMP00251

kegg_map_id:

[40]:

name:Spectinomycin Action Pathway

smpdb_id:SMP00258

kegg_map_id:

[41]:

name:Streptomycin Action Pathway

smpdb_id:SMP00259

kegg_map_id:

[42]:

name:Telithromycin Action Pathway

smpdb_id:SMP00252

kegg_map_id:

[43]:

name:Tetracycline Action Pathway

smpdb_id:SMP00294

kegg_map_id:

[44]:

name:Tigecycline Action Pathway

smpdb_id:SMP00712

kegg_map_id:

[45]:

name:Tobramycin Action Pathway

smpdb_id:SMP00711

kegg_map_id:

[46]:

name:Transcription/Translation

smpdb_id:SMP00019

kegg_map_id:

[47]:

name:Troleandomycin Action Pathway

smpdb_id:SMP00730

kegg_map_id:

[48]:

name:Valine, leucine and isoleucine degradation

smpdb_id:

kegg_map_id:map00280

正常浓度
1:

biospecimen:Blood

concentration_value:40.0 +/- 20.0

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Not Specified

subject_condition:Normal

2:

biospecimen:Blood

concentration_value:69.0 +/- 13.0

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Male

subject_condition:Normal

3:

biospecimen:Blood

concentration_value:64.0 +/- 13.0

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Female

subject_condition:Normal

4:

biospecimen:Blood

concentration_value:84.0 +/- 18.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

5:

biospecimen:Blood

concentration_value:44.0 +/- 6.0

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

6:

biospecimen:Blood

concentration_value:81.0 +/- 18.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

7:

biospecimen:Blood

concentration_value:56.0 +/- 12.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

8:

biospecimen:Blood

concentration_value:28-84

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Both

subject_condition:Normal

9:

biospecimen:Blood

concentration_value:20-90

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

10:

biospecimen:Blood

concentration_value:25-87

concentration_units:uM

subject_age:Infant (1 - 3 months old)

subject_sex:Both

subject_condition:Normal

11:

biospecimen:Blood

concentration_value:25-100

concentration_units:uM

subject_age:Children (3 months - 6 years old)

subject_sex:Both

subject_condition:Normal

12:

biospecimen:Blood

concentration_value:35-100

concentration_units:uM

subject_age:Children (6 - 18 years old)

subject_sex:Both

subject_condition:Normal

13:

biospecimen:Blood

concentration_value:37-39

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

14:

biospecimen:Blood

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

15:

biospecimen:Blood

concentration_value:83.1 (72.1-96.5)

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:

subject_condition:Normal

16:

biospecimen:Blood

concentration_value:38-94

concentration_units:uM

subject_age:Adolescent (13-18 years old)

subject_sex:Not Specified

subject_condition:Normal

17:

biospecimen:Blood

concentration_value:22-107

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

18:

biospecimen:Blood

concentration_value:68 +/- 11

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

19:

biospecimen:Blood

concentration_value:22-107

concentration_units:uM

subject_age:Children (1 - 18 years old)

subject_sex:Not Specified

subject_condition:Normal

20:

biospecimen:Blood

concentration_value:30-108

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

21:

biospecimen:Blood

concentration_value:53 +/- 7

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

22:

biospecimen:Blood

concentration_value:31-83

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

23:

biospecimen:Blood

concentration_value:92.1 (71.4-116)

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:

subject_condition:Normal

24:

biospecimen:Blood

concentration_value:39 +/- 8

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Not Specified

subject_condition:Normal

25:

biospecimen:Blood

concentration_value:76.5 +/- 18.0

concentration_units:uM

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

26:

biospecimen:Blood

concentration_value:64 +/- 13

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

27:

biospecimen:Blood

concentration_value:40.00-100.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

28:

biospecimen:Blood

concentration_value:77.5 +/- 15.4

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

29:

biospecimen:Blood

concentration_value:84 +/- 18

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

30:

biospecimen:Blood

concentration_value:51.1(44.6-60.2)

concentration_units:uM

subject_age:Children (1-13 uears old)

subject_sex:Both

subject_condition:Normal

31:

biospecimen:Blood

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

32:

biospecimen:Blood

concentration_value:62.0 (48.0-76.0)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

33:

biospecimen:Blood

concentration_value:60.7 +/- 18.6

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

34:

biospecimen:Breast Milk

concentration_value:7.9 +/- 3.3

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

35:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:4.9 +/- 0.6

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Not Specified

subject_condition:Normal

36:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:7.0 +/- 5.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

37:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:3.9 +/- 1.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

38:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:5.5 +/- 0.64

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

39:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:8.4 +/- 2.6

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

40:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:8.4 +/- 2.5

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

41:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:4.3 +/- 3.4

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

42:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:1.2-7.5

concentration_units:uM

subject_age:Children (0 - 10 years old)

subject_sex:Both

subject_condition:Normal

43:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.3-9.3

concentration_units:uM

subject_age:Adolescent (>11 years old)

subject_sex:Both

subject_condition:Normal

44:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:5.77 (3.30-8.24)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

45:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:13.5 (8.8-18.2)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

46:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

47:

biospecimen:Feces

concentration_value:4171

concentration_units:nmol/g wet feces

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

48:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

49:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

50:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Children (1-13 years old)

subject_sex:Both

subject_condition:Normal

51:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

52:

biospecimen:Feces

concentration_value:59209.384 (23912.460-94506.309)

concentration_units:nmol/g wet feces

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

53:

biospecimen:Feces

concentration_value:41395.746 (17686.580-65104.911)

concentration_units:nmol/g wet feces

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

54:

biospecimen:Feces

concentration_value:60810.325 (32222.103-89398.547)

concentration_units:nmol/g wet feces

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

55:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Not Specified

subject_sex:Both

subject_condition:Normal

56:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

57:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

58:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

59:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

60:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

61:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

62:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

63:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Children (6 - 18 years old)

subject_sex:Not Specified

subject_condition:Normal

64:

biospecimen:Feces

concentration_value:24.853 +/- 27.140

concentration_units:nmol/g wet feces

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

65:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

66:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

67:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

68:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

69:

biospecimen:Feces

concentration_value:1090 +/- 650

concentration_units:nmol/g wet feces

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

70:

biospecimen:Feces

concentration_value:1470 +/- 620

concentration_units:nmol/g wet feces

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

71:

biospecimen:Feces

concentration_value:160 +/- 160

concentration_units:nmol/g wet feces

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

72:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

73:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

74:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

75:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

76:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

77:

biospecimen:Feces

concentration_value:3733

concentration_units:nmol/g wet feces

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

78:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

79:

biospecimen:Feces

concentration_value:3644

concentration_units:nmol/g wet feces

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

80:

biospecimen:Saliva

concentration_value:6.60 +/- 9.47

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

81:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

82:

biospecimen:Saliva

concentration_value:0.0890 +/- 0.330

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

83:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

84:

biospecimen:Saliva

concentration_value:5.4 +/- 5.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

85:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

86:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

87:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

88:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

89:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

90:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

91:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

92:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

93:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

94:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

95:

biospecimen:Saliva

concentration_value:9.0 +/- 3.5

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

96:

biospecimen:Saliva

concentration_value:2.3 +/- 3.4

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

97:

biospecimen:Saliva

concentration_value:25.53 +/- 17.89

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

98:

biospecimen:Saliva

concentration_value:6.0 +/- 5.2

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

99:

biospecimen:Saliva

concentration_value:>10

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

100:

biospecimen:Saliva

concentration_value:2.36 +/- 2.74

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

101:

biospecimen:Sweat

concentration_value:40-260

concentration_units:uM

subject_age:Adult (60 years old)

subject_sex:Male

subject_condition:Normal

102:

biospecimen:Sweat

concentration_value:40

concentration_units:uM

subject_age:Adult (40 years old)

subject_sex:Male

subject_condition:Normal

103:

biospecimen:Sweat

concentration_value:

concentration_units:

subject_age:Adult

subject_sex:Both

subject_condition:Normal

104:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

105:

biospecimen:Urine

concentration_value:3.93 +/- 3.136

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

106:

biospecimen:Urine

concentration_value:<3.85

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

107:

biospecimen:Urine

concentration_value:1.64

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

108:

biospecimen:Urine

concentration_value:<3.17

concentration_units:umol/mmol creatinine

subject_age:Adolescent (13-18 years old)

subject_sex:Not Specified

subject_condition:Normal

109:

biospecimen:Urine

concentration_value:0.78-1.4

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

110:

biospecimen:Urine

concentration_value:3.05-16.78

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

111:

biospecimen:Urine

concentration_value:1.579 (0.789-2.368)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

112:

biospecimen:Urine

concentration_value:<2.49

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

113:

biospecimen:Urine

concentration_value:0.43-14.07

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Male

subject_condition:Normal

114:

biospecimen:Urine

concentration_value:0.86-16.19

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Female

subject_condition:Normal

115:

biospecimen:Urine

concentration_value:4.82 +/- 4.26

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Male

subject_condition:Normal

116:

biospecimen:Urine

concentration_value:5.68 +/- 4.59

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Female

subject_condition:Normal

117:

biospecimen:Urine

concentration_value:6.62 +/- 4.81

concentration_units:umol/mmol creatinine

subject_age:Children (0-2 years old)

subject_sex:Female

subject_condition:Normal

118:

biospecimen:Urine

concentration_value:6.83 +/- 4.78

concentration_units:umol/mmol creatinine

subject_age:Children (0-2 years old)

subject_sex:Male

subject_condition:Normal

119:

biospecimen:Urine

concentration_value:1.3 (0.4-2.6)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

120:

biospecimen:Urine

concentration_value:0.0086 - 0.0339

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

121:

biospecimen:Urine

concentration_value:1.41

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

122:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

123:

biospecimen:Urine

concentration_value:3.75 +/- 2.75

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

124:

biospecimen:Urine

concentration_value:<9.73

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

125:

biospecimen:Urine

concentration_value:< 1.0

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

126:

biospecimen:Urine

concentration_value:<1.0

concentration_units:umol/mmol creatinine

subject_age:Infant (1 - 6 months old)

subject_sex:Both

subject_condition:Normal

127:

biospecimen:Urine

concentration_value:<1.0

concentration_units:umol/mmol creatinine

subject_age:Infant (6 months - <1 year old)

subject_sex:Both

subject_condition:Normal

128:

biospecimen:Urine

concentration_value:0.94 +/- 0.67

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Both

subject_condition:Normal

129:

biospecimen:Urine

concentration_value:1.8 +/- 1.0

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

130:

biospecimen:Urine

concentration_value:3.0 +/- 1.5

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

131:

biospecimen:Urine

concentration_value:3.55 +/- 1.85

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

132:

biospecimen:Urine

concentration_value:1.3 (0.5-2.7)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

133:

biospecimen:Urine

concentration_value:<8.82

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

134:

biospecimen:Urine

concentration_value:0.71-1.1

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

135:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

136:

biospecimen:Urine

concentration_value:0.9

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

137:

biospecimen:Urine

concentration_value:3.7308 +/- 1.4276

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

138:

biospecimen:Urine

concentration_value:35.39 +/- 33.92

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

139:

biospecimen:Urine

concentration_value:46.81 +/- 29.40

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

140:

biospecimen:Urine

concentration_value:48.16 +/- 29.40

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

141:

biospecimen:Urine

concentration_value:<7.013

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

142:

biospecimen:Urine

concentration_value:0 - 6.11

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

143:

biospecimen:Urine

concentration_value:0 - 5.09

concentration_units:umol/mmol creatinine

subject_age:Infant (1 - 6 months old)

subject_sex:Both

subject_condition:Normal

144:

biospecimen:Urine

concentration_value:0 - 6.11

concentration_units:umol/mmol creatinine

subject_age:Infant (6 months - <1 year old)

subject_sex:Both

subject_condition:Normal

145:

biospecimen:Urine

concentration_value:0 - 6.11

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 2 years old)

subject_sex:Both

subject_condition:Normal

146:

biospecimen:Urine

concentration_value:0 - 16.62

concentration_units:umol/mmol creatinine

subject_age:Children (2 - 4 years old)

subject_sex:Both

subject_condition:Normal

147:

biospecimen:Urine

concentration_value:0 - 6.11

concentration_units:umol/mmol creatinine

subject_age:Children (4 - 13 years old)

subject_sex:Both

subject_condition:Normal

148:

biospecimen:Urine

concentration_value:0 - 4.07

concentration_units:umol/mmol creatinine

subject_age:Adolescent (13 - 21 years old)

subject_sex:Both

subject_condition:Normal

149:

biospecimen:Urine

concentration_value:0.29-7.30

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

150:

biospecimen:Urine

concentration_value:0 - 4.07

concentration_units:umol/mmol creatinine

subject_age:Adult (>21 years old)

subject_sex:Both

subject_condition:Normal

151:

biospecimen:Urine

concentration_value:2.73 +/- 1.52

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Female

subject_condition:Normal

152:

biospecimen:Urine

concentration_value:2.93 +/- 1.42

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Male

subject_condition:Normal

153:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

异常浓度
1:

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Oesophageal cancer

2:

biospecimen:Blood

concentration_value:44.6 +/- 21.5

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Heart Transplant

3:

biospecimen:Blood

concentration_value:477

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Female

patient_information:Maple syrup urine disease

4:

biospecimen:Blood

concentration_value:103

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Female

patient_information:Hyperlysinemia II or Saccharopinuria

5:

biospecimen:Blood

concentration_value:41.1 +/- 10.7

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy with fetuses with trisomy 18

6:

biospecimen:Blood

concentration_value:38.6 +/- 16.6

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

7:

biospecimen:Blood

concentration_value:37.6 (9.6)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Early preeclampsia

8:

biospecimen:Blood

concentration_value:46.2 (19.3)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

9:

biospecimen:Blood

concentration_value:39.5 (7-51)

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Male

patient_information:Lipoyltransferase 1 Deficiency

10:

biospecimen:Blood

concentration_value:282.0705

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Male

patient_information:Dihydrolipoamide Dehydrogenase Deficiency

11:

biospecimen:Blood

concentration_value:10-23

concentration_units:uM

patient_age:Adolescent (13-18 years old)

patient_sex:Female

patient_information:Branched-chain Keto Acid Dehydrogenase Kinase Deficiency

12:

biospecimen:Blood

concentration_value:10-26

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Branched-chain Keto Acid Dehydrogenase Kinase Deficiency

13:

biospecimen:Blood

concentration_value:77 +/- 14

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Schizophrenia

14:

biospecimen:Blood

concentration_value:9-57

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Branched-chain Keto Acid Dehydrogenase Kinase Deficiency

15:

biospecimen:Blood

concentration_value:64 +/- 15

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Schizophrenia

16:

biospecimen:Blood

concentration_value:43.24 (16.72)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy with fetus having congenital heart defect

17:

biospecimen:Blood

concentration_value:40.9 (11.7)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

18:

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

19:

biospecimen:Blood

concentration_value:492

concentration_units:uM

patient_age:Newborn (0-30 days old)

patient_sex:Female

patient_information:Maple syrup urine disease

20:

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Pancreatic cancer

21:

biospecimen:Blood

concentration_value:237-794

concentration_units:uM

patient_age:Newborn (0-30 days old)

patient_sex:Both

patient_information:Maple syrup urine disease

22:

biospecimen:Blood

concentration_value:99.0 +/- 65.3

concentration_units:uM

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Maple syrup urine disease

23:

biospecimen:Blood

concentration_value:58.6(49.2-70.0)

concentration_units:uM

patient_age:Children (1-13 uears old)

patient_sex:Both

patient_information:Environmental enteric dysfunction

24:

biospecimen:Blood

concentration_value:1495.2 +/- 373.0

concentration_units:uM

patient_age:Elderly (>65 years old)

patient_sex:Both

patient_information:Alzheimer's disease

25:

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Pancreatic cancer

26:

biospecimen:Blood

concentration_value:40.3 (38.0-42.6)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Epilepsy

27:

biospecimen:Blood

concentration_value:42.7 (38.1-47.3)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Epilepsy

28:

biospecimen:Blood

concentration_value:6100.00 (200.00-12000.00)

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Maple syrup urine disease (MSUD)

29:

biospecimen:Blood

concentration_value:166.0 +/- 5.0

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Heart failure

30:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:216

concentration_units:uM

patient_age:Newborn (0-30 days old)

patient_sex:Female

patient_information:Maple syrup urine disease

31:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:338

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Female

patient_information:Maple syrup urine disease

32:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:6.0 +/- 0.65

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Schizophrenia

33:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:2.4 +/- 0.65

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Alzheimer's disease

34:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:7.1 +/- 4.2

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Not Specified

patient_information:Leukemia

35:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:5.9 +/- 4.0

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Not Specified

patient_information:Leukemia

36:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal Cancer

37:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Autism

38:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Irritable bowel syndrome

39:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Ulcerative colitis

40:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Not Specified

patient_sex:Not Specified

patient_information:Cryptosporidium infection

41:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Myalgic encephalomyelitis/chronic fatigue syndrome

42:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Crohns disease

43:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Ulcerative colitis

44:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Unclassified IBD

45:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

46:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

47:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Irritable Bowel Syndrome

48:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal Cancer

49:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Crohn’s Disease

50:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Ulcerative Colitis

51:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Crohn's disease

52:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Ulcerative colitis

53:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Crohns disease

54:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Ulcerative colitis

55:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Attachment loss 

56:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Missing teeth

57:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Periodontal Probing Depth

58:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Oral cancer

59:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Breast cancer

60:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Not Specified

patient_information:Pancreatic cancer

61:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Not Specified

patient_information:Periodontal diseases

62:

biospecimen:Saliva

concentration_value:0.83 +/- 0.21

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Alzheimer's disease

63:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Oral squamous cell carcinoma (OSCC)

64:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Oral leukoplakia (OLK)

65:

biospecimen:Saliva

concentration_value:1.22 +/- 0.30

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Frontotemporal lobe dementia

66:

biospecimen:Saliva

concentration_value:1.54 +/- 0.98

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Lewy body disease

67:

biospecimen:Urine

concentration_value:4.211 +/- 5.162

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Eosinophilic esophagitis

68:

biospecimen:Urine

concentration_value:0.0053 - 0.0143

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:ADPKD

69:

biospecimen:Urine

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

70:

biospecimen:Urine

concentration_value:0.13 +/- 0.04

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Alzheimer's disease

71:

biospecimen:Urine

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Schizophrenia

72:

biospecimen:Urine

concentration_value:3.0408 +/- 2.1926

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Eosinophilic esophagitis

73:

biospecimen:Urine

concentration_value:2.8234 +/- 1.7792

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Gastroesophageal reflux disease

疾病参考
1:

name:Epilepsy

omim_id:

[1]:

reference_text:Rainesalo S, Keranen T, Palmio J, Peltola J, Oja SS, Saransaari P: Plasma and cerebrospinal fluid amino acids in epileptic patients. Neurochem Res. 2004 Jan;29(1):319-24.

pubmed_id:14992292

[2]:

reference_text:Cady EB, Lorek A, Penrice J, Reynolds EO, Iles RA, Burns SP, Coutts GA, Cowan FM: Detection of propan-1,2-diol in neonatal brain by in vivo proton magnetic resonance spectroscopy. Magn Reson Med. 1994 Dec;32(6):764-7.

pubmed_id:7869898

[3]:

reference_text:Perosa SR, Porcionatto MA, Cukiert A, Martins JR, Amado D, Nader HB, Cavalheiro EA, Leite JP, Naffah-Mazzacoratti MG: Extracellular matrix components are altered in the hippocampus, cortex, and cerebrospinal fluid of patients with mesial temporal lobe epilepsy. Epilepsia. 2002;43 Suppl 5:159-61.

pubmed_id:12121313

[4]:

reference_text:Spanaki MV, Siegel H, Kopylev L, Fazilat S, Dean A, Liow K, Ben-Menachem E, Gaillard WD, Theodore WH: The effect of vigabatrin (gamma-vinyl GABA) on cerebral blood flow and metabolism. Neurology. 1999 Oct 22;53(7):1518-22.

pubmed_id:10534261

[5]:

reference_text:Rating D, Siemes H, Loscher W: Low CSF GABA concentration in children with febrile convulsions, untreated epilepsy, and meningitis. J Neurol. 1983;230(4):217-25.

pubmed_id:6198481

[6]:

reference_text:Botez MI, Young SN: Effects of anticonvulsant treatment and low levels of folate and thiamine on amine metabolites in cerebrospinal fluid. Brain. 1991 Feb;114 ( Pt 1A):333-48.

pubmed_id:1705463

[7]:

reference_text:Kobayashi K, Koide Y, Yoshino K, Shohmori T: [P-hydroxyphenylacetic acid concentrations in cerebrospinal fluid]. No To Shinkei. 1982 Aug;34(8):769-74.

pubmed_id:7126379

[8]:

reference_text:Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90.

pubmed_id:15993662

[9]:

reference_text:Shaywitz BA, Cohen DJ, Bowers MB: Reduced cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in children with epilepsy. Neurology. 1975 Jan;25(1):72-9.

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pubmed_id:15607313

[3]:

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pubmed_id:14569192

[4]:

reference_text:Zhang Z, Chen H, Chan KK, Budd T, Ganapathi R: Gas chromatographic-mass spectrometric analysis of perillyl alcohol and metabolites in plasma. J Chromatogr B Biomed Sci Appl. 1999 May 14;728(1):85-95.

pubmed_id:10379660

[5]:

reference_text:Grace PB, Mistry NS, Carter MH, Leathem AJ, Teale P: High throughput quantification of phytoestrogens in human urine and serum using liquid chromatography/tandem mass spectrometry (LC-MS/MS). J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 15;853(1-2):138-46. Epub 2007 Mar 18.

pubmed_id:17403619

[6]:

reference_text:Silva CL, Passos M, Camara JS: Solid phase microextraction, mass spectrometry and metabolomic approaches for detection of potential urinary cancer biomarkers--a powerful strategy for breast cancer diagnosis. Talanta. 2012 Jan 30;89:360-8. doi: 10.1016/j.talanta.2011.12.041. Epub 2011 Dec 22.

pubmed_id:22284503

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reference_text:Sugimoto M, Wong DT, Hirayama A, Soga T, Tomita M: Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles. Metabolomics. 2010 Mar;6(1):78-95. Epub 2009 Sep 10.

pubmed_id:20300169

[8]:

reference_text:Lv W, Yang T: Identification of possible biomarkers for breast cancer from free fatty acid profiles determined by GC-MS and multivariate statistical analysis. Clin Biochem. 2012 Jan;45(1-2):127-33. doi: 10.1016/j.clinbiochem.2011.10.011. Epub 2011 Oct 26.

pubmed_id:22061338

[9]:

reference_text:Nam H, Chung BC, Kim Y, Lee K, Lee D: Combining tissue transcriptomics and urine metabolomics for breast cancer biomarker identification. Bioinformatics. 2009 Dec 1;25(23):3151-7. doi: 10.1093/bioinformatics/btp558. Epub 2009 Sep 25.

pubmed_id:19783829

[10]:

reference_text:Woo HM, Kim KM, Choi MH, Jung BH, Lee J, Kong G, Nam SJ, Kim S, Bai SW, Chung BC: Mass spectrometry based metabolomic approaches in urinary biomarker study of women's cancers. Clin Chim Acta. 2009 Feb;400(1-2):63-9. doi: 10.1016/j.cca.2008.10.014. Epub 2008 Oct 30.

pubmed_id:19010317

19:

name:Pancreatic cancer

omim_id:260350

[1]:

reference_text:Loser C, Folsch UR, Paprotny C, Creutzfeldt W: Polyamine concentrations in pancreatic tissue, serum, and urine of patients with pancreatic cancer. Pancreas. 1990 Mar;5(2):119-27.

pubmed_id:2315288

[2]:

reference_text:Sugimoto M, Wong DT, Hirayama A, Soga T, Tomita M: Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles. Metabolomics. 2010 Mar;6(1):78-95. Epub 2009 Sep 10.

pubmed_id:20300169

[3]:

reference_text:Zhang L, Jin H, Guo X, Yang Z, Zhao L, Tang S, Mo P, Wu K, Nie Y, Pan Y, Fan D: Distinguishing pancreatic cancer from chronic pancreatitis and healthy individuals by (1)H nuclear magnetic resonance-based metabonomic profiles. Clin Biochem. 2012 Sep;45(13-14):1064-9. doi: 10.1016/j.clinbiochem.2012.05.012. Epub 2012 May 19.

pubmed_id:22613268

[4]:

reference_text:OuYang D, Xu J, Huang H, Chen Z: Metabolomic profiling of serum from human pancreatic cancer patients using 1H NMR spectroscopy and principal component analysis. Appl Biochem Biotechnol. 2011 Sep;165(1):148-54. doi: 10.1007/s12010-011-9240-0. Epub 2011 Apr 20.

pubmed_id:21505807

[5]:

reference_text:Xie G, Lu L, Qiu Y, Ni Q, Zhang W, Gao YT, Risch HA, Yu H, Jia W: Plasma metabolite biomarkers for the detection of pancreatic cancer. J Proteome Res. 2015 Feb 6;14(2):1195-202. doi: 10.1021/pr501135f. Epub 2014 Dec 8.

pubmed_id:25429707

20:

name:Periodontal disease

omim_id:170650

[1]:

reference_text:Sugimoto M, Wong DT, Hirayama A, Soga T, Tomita M: Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles. Metabolomics. 2010 Mar;6(1):78-95. Epub 2009 Sep 10.

pubmed_id:20300169

21:

name:Frontotemporal dementia

omim_id:600274

[1]:

reference_text:Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6.

pubmed_id:23857558

22:

name:Lewy body disease

omim_id:

[1]:

reference_text:Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6.

pubmed_id:23857558

23:

name:Attachment loss

omim_id:

[1]:

reference_text:Liebsch C, Pitchika V, Pink C, Samietz S, Kastenmuller G, Artati A, Suhre K, Adamski J, Nauck M, Volzke H, Friedrich N, Kocher T, Holtfreter B, Pietzner M: The Saliva Metabolome in Association to Oral Health Status. J Dent Res. 2019 Jun;98(6):642-651. doi: 10.1177/0022034519842853. Epub 2019 Apr 26.

pubmed_id:31026179

24:

name:Missing teeth

omim_id:

[1]:

reference_text:Liebsch C, Pitchika V, Pink C, Samietz S, Kastenmuller G, Artati A, Suhre K, Adamski J, Nauck M, Volzke H, Friedrich N, Kocher T, Holtfreter B, Pietzner M: The Saliva Metabolome in Association to Oral Health Status. J Dent Res. 2019 Jun;98(6):642-651. doi: 10.1177/0022034519842853. Epub 2019 Apr 26.

pubmed_id:31026179

25:

name:Periodontal Probing Depth

omim_id:

[1]:

reference_text:Liebsch C, Pitchika V, Pink C, Samietz S, Kastenmuller G, Artati A, Suhre K, Adamski J, Nauck M, Volzke H, Friedrich N, Kocher T, Holtfreter B, Pietzner M: The Saliva Metabolome in Association to Oral Health Status. J Dent Res. 2019 Jun;98(6):642-651. doi: 10.1177/0022034519842853. Epub 2019 Apr 26.

pubmed_id:31026179

26:

name:Autosomal dominant polycystic kidney disease

omim_id:601313

[1]:

reference_text:Wang D, Strandgaard S, Borresen ML, Luo Z, Connors SG, Yan Q, Wilcox CS: Asymmetric dimethylarginine and lipid peroxidation products in early autosomal dominant polycystic kidney disease. Am J Kidney Dis. 2008 Feb;51(2):184-91. doi: 10.1053/j.ajkd.2007.09.020.

pubmed_id:18215696

[2]:

reference_text:Gronwald W, Klein MS, Zeltner R, Schulze BD, Reinhold SW, Deutschmann M, Immervoll AK, Boger CA, Banas B, Eckardt KU, Oefner PJ: Detection of autosomal dominant polycystic kidney disease by NMR spectroscopic fingerprinting of urine. Kidney Int. 2011 Jun;79(11):1244-53. doi: 10.1038/ki.2011.30. Epub 2011 Mar 9.

pubmed_id:21389975

27:

name:Eosinophilic esophagitis

omim_id:610247

[1]:

reference_text:Mordechai, Hien, and David S. Wishart

pubmed_id:

KEGG数据库编号
C00407
DrugBank数据库编号
DB00167
foodb数据库编号
FDB012397
ChemSpider数据库编号
6067
公共化学化合物编号
6306
PDB数据库编号
生物利益的化学实体数据库编号
17191
knapsack数据库编号
C00001374
维基百科编号
Isoleucine
代谢途径的数据库编号
ILE
苯酚资源管理器化合物数据库编号
比格数据库编号
34887
梅林编号
5193
虚拟机身份证编号
ILE_L
fbonto数据库编号
综合参考
Marvel, C. S. L-Isoleucine. Organic Syntheses (1941), 21 60-4.
一般参考
1:

protein_accession:HMDBP00301

name:Branched-chain-amino-acid aminotransferase, cytosolic

uniprot_id:P54687

gene_name:BCAT1

protein_type:Enzyme

2:

protein_accession:HMDBP00516

name:Branched-chain-amino-acid aminotransferase, mitochondrial

uniprot_id:O15382

gene_name:BCAT2

protein_type:Enzyme

3:

protein_accession:HMDBP00614

name:Isoleucine--tRNA ligase, cytoplasmic

uniprot_id:P41252

gene_name:IARS

protein_type:Enzyme

4:

protein_accession:HMDBP01613

name:Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

uniprot_id:P45954

gene_name:ACADSB

protein_type:Unknown

5:

protein_accession:HMDBP05340

name:Monocarboxylate transporter 10

uniprot_id:Q8TF71

gene_name:SLC16A10

protein_type:Transporter

6:

protein_accession:HMDBP08281

name:L-amino-acid oxidase

uniprot_id:Q96RQ9

gene_name:IL4I1

protein_type:Unknown

7:

protein_accession:HMDBP10675

name:Isoleucine--tRNA ligase, mitochondrial

uniprot_id:Q9NSE4

gene_name:IARS2

protein_type:Enzyme

蛋白质结合
1:

reference_text:Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762.

pubmed_id:19212411

2:

reference_text:Silwood CJ, Lynch E, Claxson AW, Grootveld MC: 1H and (13)C NMR spectroscopic analysis of human saliva. J Dent Res. 2002 Jun;81(6):422-7.

pubmed_id:12097436

3:

reference_text:Nicholson JK, O'Flynn MP, Sadler PJ, Macleod AF, Juul SM, Sonksen PH: Proton-nuclear-magnetic-resonance studies of serum, plasma and urine from fasting normal and diabetic subjects. Biochem J. 1984 Jan 15;217(2):365-75.

pubmed_id:6696735

4:

reference_text:Engelborghs S, Marescau B, De Deyn PP: Amino acids and biogenic amines in cerebrospinal fluid of patients with Parkinson's disease. Neurochem Res. 2003 Aug;28(8):1145-50.

pubmed_id:12834252

5:

reference_text:Hagenfeldt L, Bjerkenstedt L, Edman G, Sedvall G, Wiesel FA: Amino acids in plasma and CSF and monoamine metabolites in CSF: interrelationship in healthy subjects. J Neurochem. 1984 Mar;42(3):833-7.

pubmed_id:6198473

6:

reference_text:Peng CT, Wu KH, Lan SJ, Tsai JJ, Tsai FJ, Tsai CH: Amino acid concentrations in cerebrospinal fluid in children with acute lymphoblastic leukemia undergoing chemotherapy. Eur J Cancer. 2005 May;41(8):1158-63. Epub 2005 Apr 14.

pubmed_id:15911239

7:

reference_text:Cynober LA: Plasma amino acid levels with a note on membrane transport: characteristics, regulation, and metabolic significance. Nutrition. 2002 Sep;18(9):761-6.

pubmed_id:12297216

8:

reference_text:Rainesalo S, Keranen T, Palmio J, Peltola J, Oja SS, Saransaari P: Plasma and cerebrospinal fluid amino acids in epileptic patients. Neurochem Res. 2004 Jan;29(1):319-24.

pubmed_id:14992292

9:

reference_text:He XY, Yang SY: Roles of type 10 17beta-hydroxysteroid dehydrogenase in intracrinology and metabolism of isoleucine and fatty acids. Endocr Metab Immune Disord Drug Targets. 2006 Mar;6(1):95-102.

pubmed_id:16611167

10:

reference_text:Vaalasti A, Suomalainen H, Kuokkanen K, Rechardt L: Neuropeptides in cutaneous neurofibromas of von Recklinghausen's disease. J Cutan Pathol. 1990 Dec;17(6):371-3.

pubmed_id:1981573

11:

reference_text:Eriste E, Norberg A, Bonetto V, Nepomuceno D, Lovenberg TW, Sillard R, Jornvall H: A C-terminally elongated form of PHI from porcine intestine. Cell Mol Life Sci. 1999 Nov 15;56(7-8):709-13.

pubmed_id:11212317

12:

reference_text:Jalan R, Olde Damink SW, Lui HF, Glabus M, Deutz NE, Hayes PC, Ebmeier K: Oral amino acid load mimicking hemoglobin results in reduced regional cerebral perfusion and deterioration in memory tests in patients with cirrhosis of the liver. Metab Brain Dis. 2003 Mar;18(1):37-49.

pubmed_id:12603081

13:

reference_text:Hervieu G, Segretain D, Nahon JL: Developmental and stage-dependent expression of melanin-concentrating hormone in mammalian germ cells. Biol Reprod. 1996 Jun;54(6):1161-72.

pubmed_id:8724342

14:

reference_text:Suk FM, Lin MH, Newman M, Pan S, Chen SH, Liu JD, Shih C: Replication advantage and host factor-independent phenotypes attributable to a common naturally occurring capsid mutation (I97L) in human hepatitis B virus. J Virol. 2002 Dec;76(23):12069-77.

pubmed_id:12414948

15:

reference_text:De Miranda J, Panizzutti R, Foltyn VN, Wolosker H: Cofactors of serine racemase that physiologically stimulate the synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14542-7. Epub 2002 Oct 22.

pubmed_id:12393813

16:

reference_text:Blomstrand E, Eliasson J, Karlsson HK, Kohnke R: Branched-chain amino acids activate key enzymes in protein synthesis after physical exercise. J Nutr. 2006 Jan;136(1 Suppl):269S-73S.

pubmed_id:16365096

17:

reference_text:Sato T, Shimada Y, Nagasawa N, Nakanishi S, Jingami H: Amino acid mutagenesis of the ligand binding site and the dimer interface of the metabotropic glutamate receptor 1. Identification of crucial residues for setting the activated state. J Biol Chem. 2003 Feb 7;278(6):4314-21. Epub 2002 Nov 19.

pubmed_id:12444084

18:

reference_text:Edvinsson L: Innervation and effects of dilatory neuropeptides on cerebral vessels. New aspects. Blood Vessels. 1991;28(1-3):35-45.

pubmed_id:2001478

19:

reference_text:Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043.

pubmed_id:32033212

20:

reference_text:Allahwala A, Ahmed S, Afroze B: Maple syrup urine disease: magnetic resonance imaging findings in three patients. J Pak Med Assoc. 2021 Apr;71(4):1309-1313. doi: 10.47391/JPMA.1341.

pubmed_id:34125801

21:

reference_text:Lynch CJ, Adams SH: Branched-chain amino acids in metabolic signalling and insulin resistance. Nat Rev Endocrinol. 2014 Dec;10(12):723-36. doi: 10.1038/nrendo.2014.171. Epub 2014 Oct 7.

pubmed_id:25287287

22:

reference_text:Xiao F, Yu J, Guo Y, Deng J, Li K, Du Y, Chen S, Zhu J, Sheng H, Guo F: Effects of individual branched-chain amino acids deprivation on insulin sensitivity and glucose metabolism in mice. Metabolism. 2014 Jun;63(6):841-50. doi: 10.1016/j.metabol.2014.03.006. Epub 2014 Mar 15.

pubmed_id:24684822

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