创建日期
2005-11-16 15:48:42 UTC
更新日期
2021-09-14 15:44:47 UTC
描述
D-Mannose (also called Mannose or D-mannopyranose) is a hexose or a six-carbon sugar. It is also classified as an aldohexose. It is fermentable monosaccharide and an isomer of glucose. Mannose commonly exists as two different-sized rings, the pyranose (six-membered) form and the furanose (five-membered) form. Formally, D-Mannose is the 2-epimer of glucose and exists primarily as sweet-tasting alpha- (67%) or as a bitter-tasting beta- (33%) anomer of the pyranose form (PMID: 24931670). Mannose is not an essential nutrient, meaning that it can be produced in the human body from glucose or converted into glucose. Mannose is ~5x as active as glucose in non-enzyamtic glycation, which may explain why evolution did not favor it as a biological energy source (PMID: 24931670). Mannose occurs in microbes, plants and animals. Free mannose is found in small amounts in many fruits such as oranges, apples and peaches and in mammalian plasma at 50–100 uM (PMID: 24931670). More often, mannose occurs in homo-or hetero-polymers such as yeast mannans (alpha-mannose) where it can account for nearly 16% of dry weight or in galactomannans. Coffee beans, fenugreek and guar gums are rich sources of galactomannans. However, these plant polysaccharides are not degraded in the mammalian GI tract and, therefore, provide very little bio-available mannose for glycan synthesis. The digestion of many polysaccharides and glycoproteins also yields mannose. Once mannose is released, it is phosphorylated by hexokinase to generate mannose-6-phosphate. Mannose-6-phosphate is then converted to fructose-6-phosphate, by the enzyme phosphomannose isomerase, whereupon it enters the glycolytic pathway or is converted to glucose-6-phosphate by the gluconeogenic pathway. Mannose is a dominant monosaccharide in N-linked glycosylation, which is a post-translational modification of proteins. N-linked glycosylation is initiated by the transfer of Glc3Man9GlcNAc2 to nascent glycoproteins in the endoplasmic reticulum in a co-translational manner as the protein enters the transport system. Typically, mature human glycoproteins only contain three mannose residues buried under sequential modification by GlcNAc, galactose, and sialic acid. High-mannose-type oligosaccharides have been shown to play important roles in protein quality control. Several intracellular proteins such as lectins, chaperones, and glycan-processing enzymes, are involved in this process. These include calnexin/calreticulin, UDP-glucose:glycoprotein glucosyltransferase (UGGT), cargo receptors (such as VIP36 and ERGIC-53), mannosidase-like proteins (e.g. EDEM and Htm1p) and ubiquitin ligase (Fbs). They are thought to recognize high-mannose-type glycans with subtly different structures. Mannose-binding lectin (MBL) is an important constituent of the innate immune system. This protein binds through multiple lectin domains to the repeating sugar arrays that decorate many microbial surfaces and is then able to activate the complement system through a specific protease called MBL-associated protease-2. Mannose (D-mannose) is used as a nutritional supplement, packaged as "D-mannose", to prevent recurrent urinary tract infections (PMID: 21105658). D-mannose prevents FimH-mediated bacterial adhesion in the urinary tract through a competitive inhibition mechanism. This mechanism is based on the structural similarity between D-mannose and urothelial mannosylated receptors exposed by the epithelium of the urinary tract (PMID: 21105658). When D-mannose is administered in sufficient amounts, it is rapidly absorbed and then excreted by the urinary tract where it saturates bacterial FimH, thereby preventing bacterial binding to urothelial cells.
同义词
1:alpha-D-Man
2:a-D-Man
3:α-D-Man
4:a-D-Mannose
5:α-D-Mannose
6:alpha-D-Mannopyranose
7:a-D-Mannopyranose
8:α-D-Mannopyranose
9:(+)-Mannose
10:Carubinose
11:D(+)-Mannose
12:Mannose
13:Seminose
14:alpha-D-Mannose
15:alpha-Mannose
16:α-Mannose
化学名称
(2S,3S,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol
代谢物结构字符串
OC[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O
inchi标识符
InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6+/m1/s1
印记键
WQZGKKKJIJFFOK-PQMKYFCFSA-N
分类学
description: belongs to the class of organic compounds known as hexoses. These are monosaccharides in which the sugar unit is a is a six-carbon containing moeity.
description:Hexoses
kingdom:Organic compounds
super_class:Organic oxygen compounds
class:Organooxygen compounds
sub_class:Carbohydrates and carbohydrate conjugates
molecular_framework:Aliphatic heteromonocyclic compounds
1:Hemiacetals
2:Hydrocarbon derivatives
3:Oxacyclic compounds
4:Oxanes
5:Polyols
6:Primary alcohols
7:Secondary alcohols
8:Alcohol
9:Aliphatic heteromonocyclic compound
10:Hemiacetal
11:Hexose monosaccharide
12:Hydrocarbon derivative
13:Organoheterocyclic compound
14:Oxacycle
15:Oxane
16:Polyol
17:Primary alcohol
18:Secondary alcohol
19:D-mannopyranose
本体论
term:Disposition
definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.
parent_id:
level:1
type:parent
term:Route of exposure
definition:A mean by which a chemical agent comes in contact with an organism, either under intended or unintended circumstances.
parent_id:7724
*level:2
type:parent
term:Enteral
definition:Chemical exposure via the alimentary canal (mouth to anus).
parent_id:7743
**level:3
type:parent
term:Ingestion
definition:Chemical exposure facilitated by entry through the mouth.
parent_id:7744
***level:4
type:child
synonym:Digestion
term:Source
definition:Natural or synthetic origin of a chemical.
parent_id:7724
*level:2
type:parent
term:Endogenous
definition:
parent_id:7735
**level:3
type:child
term:Food
definition:
parent_id:7735
**level:3
type:child
term:Biological
definition:A living organism (species or a higher taxonomy rank), in which a chemical can be found.
parent_id:7735
**level:3
type:parent
term:Plant
definition:A living organism belonging to the kingdom plantea. typically, it grows in a permanent site, absorbs water and inorganic substances through its roots, and synthesizes nutrients in its leaves by photosynthesis using the green pigment chlorophyll. examples incude trees, shrubs, herbs, grasses, ferns, and mosses.
parent_id:7736
***level:4
type:parent
synonym:Flora
term:Biological location
definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.
parent_id:7724
*level:2
type:parent
term:Organ and components
definition:An anatomical organizational level including multiple tissues or substructures, which enables a common biological function.
parent_id:7725
**level:3
type:parent
term:Intestine
definition:The portion of the gastrointestinal tract that includes the small and large intestines.
parent_id:7727
***level:4
type:child
term:Testicle
definition:Either of the paired male reproductive glands that produce the male germ cells and the male hormones. (nci).
parent_id:7727
***level:4
type:child
synonym:Testes
synonym:Testis
term:Spleen
definition:An abdominal organ that is part of the hematopoietic and immune systems. it is composed of the white pulp and the red pulp and is surrounded by a capsule. (nci).
parent_id:7727
***level:4
type:child
term:Bladder
definition:The distensible sac-like organ that functions as a reservoir of urine, collecting from the kidneys and eliminating via the urethra. (nci).
parent_id:7727
***level:4
type:child
term:Prostate
definition:The male reproductive accessory gland that produces prostatic fluid and is located adjacent to or around the urethra distal to the urinary bladder in mammals. (nci).
parent_id:7727
***level:4
type:child
synonym:Prostate gland
term:Kidney
definition:The organs of the urinary tract located in the retroperitoneal cavity adjacent to the spine and composed of the renal cortex and the renal medulla. (nci).
parent_id:7727
***level:4
type:child
synonym:Kidneys
term:Pancreas
definition:A digestive organ in the abdomen that has both endocrine and exocrine functions. (nci).
parent_id:7727
***level:4
type:child
term:Tissue and substructures
definition:An anatomical organizational level including multiple cells yet not comprising a complete organ .
parent_id:7725
**level:3
type:parent
term:Placenta
definition:An organ present in some vertebrates during embryonic gestation that surrounds the fetus and provides it with nutrients and oxygen, facilitates gas and waste exchange between the fetus and mother, and provides parasitic cloaking from the mother's immune system by excretion of neurokinin b. (nci).
parent_id:7729
***level:4
type:child
term:Epidermis
definition:The epithelial portion of the skin (cutis). it consists of the following layers: stratum corneum (horny layer), stratum granulosum (granular layer), stratum spinosum (prickle cell layer), and stratum basale (basal cell layer). (nci).
parent_id:7729
***level:4
type:child
term:Muscle
definition:A fibrous soft tissue with the ability to contract to produce force and motion. (nci).
parent_id:7729
***level:4
type:child
term:Biofluid and excreta
definition:A liquid, semi-solid or solid material originating in the body.
parent_id:7725
**level:3
type:parent
term:Urine
definition:Excretion in liquid state processed by the kidney.
parent_id:7731
***level:4
type:child
term:Saliva
definition:The watery fluid in the mouth made by the salivary glands. saliva moistens food to help digestion and it helps protect the mouth against infections. (nci).
parent_id:7731
***level:4
type:child
term:Feces
definition:The material discharged from the bowel during defecation. It consists of undigested food, intestinal mucus, epithelial cells, and bacteria.
parent_id:7731
***level:4
type:child
synonym:Fecal
synonym:Stool
synonym:Faecal
synonym:Faeces
term:Blood
definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.
parent_id:7731
***level:4
type:child
term:Breast milk
definition:Portion of secreted substance produced by the mammary gland.
parent_id:7731
***level:4
type:child
term:Cerebrospinal fluid
definition:The fluid that is contained within the brain ventricles, the subarachnoid space and the central canal of the spinal cord. (nci).
parent_id:7731
***level:4
type:child
synonym:Csf
term:Subcellular
definition:An anatomical organizational level including a component within a biological cell .
parent_id:7725
**level:3
type:parent
term:Cytoplasm
definition:The portion of the cell contained within the plasma membrane but excluding the nucleus.
parent_id:7730
***level:4
type:child
synonym:Cytoplasma
term:Lysosome
definition:В A sac-like compartment inside a cell that has enzymes that can break down cellular components that need to be destroyed. (NCI).
parent_id:7730
***level:4
type:child
term:Endoplasmic reticulum
definition:A network of tubular membranes within the cytoplasm of the cell, occurring either with a smooth surface (smooth endoplasmic reticulum) or studded with ribosomes (rough endoplasmic reticulum), involved in the transport of materials. (Infoplease Dictionary via NCI)
parent_id:7730
***level:4
type:child
synonym:Er
term:Golgi
definition:A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. Note that the Golgi apparatus can be located in various places in the cytoplasm.
parent_id:7730
***level:4
type:child
synonym:Golgi apparatus
synonym:Golgi complex
synonym:Golgi ribbon
term:Myelin sheath
definition:A layer of phospholipids and protein found on neuronal axons. this structure acts as an electrical insulator that allows nerve impulses to travel faster by increasing the resistance and decreasing the capacitance over that found in unmyelinated nerve fibers. (nci).
parent_id:7730
***level:4
type:child
synonym:Myelin
term:Cell and elements
definition:An anatomical organizational level comprising of a single cell (or a fragment in some exceptions). a cell is defined by its type or function. it is the smallest unit of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid.
parent_id:7725
**level:3
type:parent
term:Extracellular
definition:The space external to the outermost structure of a cell.
parent_id:7732
***level:4
type:child
synonym:Extracellular region
term:Cell
definition:
parent_id:7732
***level:4
type:parent
term:Process
definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.
parent_id:
level:1
type:parent
term:Naturally occurring process
definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.
parent_id:7659
*level:2
type:parent
term:Biological process
definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.
parent_id:7660
**level:3
type:parent
term:Biochemical pathway
definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.
parent_id:7661
***level:4
type:parent
实验性质
1:
kind:water_solubility
value:713.0 mg/mL at 17 °C
source:
2:
kind:melting_point
value:132 °C
source:
预测性质
1:
kind:logp
value:-2.57
source:ALOGPS
2:
kind:logs
value:0.64
source:ALOGPS
3:
kind:solubility
value:782 g/L
source:ALOGPS
4:
kind:logp
value:-2.9
source:ChemAxon
5:
kind:pka_strongest_acidic
value:11.3
source:ChemAxon
6:
kind:pka_strongest_basic
value:-3
source:ChemAxon
7:
kind:iupac
value:(2S,3S,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol
source:ChemAxon
8:
kind:average_mass
value:180.1559
source:ChemAxon
9:
kind:mono_mass
value:180.063388116
source:ChemAxon
10:
kind:smiles
value:OC[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O
source:ChemAxon
11:
kind:formula
value:C6H12O6
source:ChemAxon
12:
kind:inchi
value:InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6+/m1/s1
source:ChemAxon
13:
kind:inchikey
value:WQZGKKKJIJFFOK-PQMKYFCFSA-N
source:ChemAxon
14:
kind:polar_surface_area
value:110.38
source:ChemAxon
15:
kind:refractivity
value:35.92
source:ChemAxon
16:
kind:polarizability
value:16.13
source:ChemAxon
17:
kind:rotatable_bond_count
value:1
source:ChemAxon
18:
kind:acceptor_count
value:6
source:ChemAxon
19:
kind:donor_count
value:5
source:ChemAxon
20:
kind:physiological_charge
value:0
source:ChemAxon
21:
kind:formal_charge
value:0
source:ChemAxon
22:
kind:number_of_rings
value:1
source:ChemAxon
23:
kind:bioavailability
value:Yes
source:ChemAxon
24:
kind:rule_of_five
value:Yes
source:ChemAxon
25:
kind:ghose_filter
value:No
source:ChemAxon
26:
kind:veber_rule
value:No
source:ChemAxon
27:
kind:mddr_like_rule
value:No
source:ChemAxon
1:
type:Specdb::CMs
spectrum_id:2356
2:
type:Specdb::CMs
spectrum_id:102823
3:
type:Specdb::CMs
spectrum_id:102824
4:
type:Specdb::CMs
spectrum_id:102825
5:
type:Specdb::CMs
spectrum_id:102826
6:
type:Specdb::CMs
spectrum_id:102827
7:
type:Specdb::CMs
spectrum_id:102828
8:
type:Specdb::CMs
spectrum_id:102829
9:
type:Specdb::CMs
spectrum_id:102830
10:
type:Specdb::CMs
spectrum_id:102831
11:
type:Specdb::CMs
spectrum_id:102832
12:
type:Specdb::CMs
spectrum_id:102833
13:
type:Specdb::CMs
spectrum_id:102834
14:
type:Specdb::CMs
spectrum_id:102835
15:
type:Specdb::CMs
spectrum_id:102836
16:
type:Specdb::CMs
spectrum_id:146311
17:
type:Specdb::NmrTwoD
spectrum_id:2075
18:
type:Specdb::MsMs
spectrum_id:177984
19:
type:Specdb::MsMs
spectrum_id:177985
20:
type:Specdb::MsMs
spectrum_id:177986
21:
type:Specdb::MsMs
spectrum_id:180297
22:
type:Specdb::MsMs
spectrum_id:180298
23:
type:Specdb::MsMs
spectrum_id:180299
24:
type:Specdb::MsMs
spectrum_id:1448605
25:
type:Specdb::MsMs
spectrum_id:1448606
26:
type:Specdb::MsMs
spectrum_id:1448607
27:
type:Specdb::MsMs
spectrum_id:2369861
28:
type:Specdb::MsMs
spectrum_id:2369862
29:
type:Specdb::MsMs
spectrum_id:2369863
30:
type:Specdb::MsMs
spectrum_id:2569244
31:
type:Specdb::MsMs
spectrum_id:2569245
32:
type:Specdb::MsMs
spectrum_id:2569246
33:
type:Specdb::NmrOneD
spectrum_id:5261
34:
type:Specdb::NmrOneD
spectrum_id:5262
35:
type:Specdb::NmrOneD
spectrum_id:5263
36:
type:Specdb::NmrOneD
spectrum_id:142690
37:
type:Specdb::NmrOneD
spectrum_id:142691
38:
type:Specdb::NmrOneD
spectrum_id:142692
39:
type:Specdb::NmrOneD
spectrum_id:142693
40:
type:Specdb::NmrOneD
spectrum_id:142694
41:
type:Specdb::NmrOneD
spectrum_id:142695
42:
type:Specdb::NmrOneD
spectrum_id:142696
43:
type:Specdb::NmrOneD
spectrum_id:142697
44:
type:Specdb::NmrOneD
spectrum_id:142698
45:
type:Specdb::NmrOneD
spectrum_id:142699
46:
type:Specdb::NmrOneD
spectrum_id:142700
47:
type:Specdb::NmrOneD
spectrum_id:142701
48:
type:Specdb::NmrOneD
spectrum_id:142702
49:
type:Specdb::NmrOneD
spectrum_id:142703
50:
type:Specdb::NmrOneD
spectrum_id:142704
51:
type:Specdb::NmrOneD
spectrum_id:142705
52:
type:Specdb::NmrOneD
spectrum_id:142706
53:
type:Specdb::NmrOneD
spectrum_id:142707
54:
type:Specdb::NmrOneD
spectrum_id:142708
55:
type:Specdb::NmrOneD
spectrum_id:142709
56:
type:Specdb::NmrOneD
spectrum_id:166523
生物学性质
1:
cellular:(1):Cytoplasm
cellular:(2):Endoplasmic reticulum
cellular:(3):Extracellular
cellular:(4):Golgi apparatus
cellular:(5):Lysosome
2:
biospecimen:(1):Blood
biospecimen:(2):Breast Milk
biospecimen:(3):Cerebrospinal Fluid (CSF)
biospecimen:(4):Feces
biospecimen:(5):Saliva
biospecimen:(6):Urine
3:
tissue:(1):Adrenal Medulla
tissue:(2):Bladder
tissue:(3):Epidermis
tissue:(4):Fibroblasts
tissue:(5):Intestine
tissue:(6):Kidney
tissue:(7):Neuron
tissue:(8):Pancreas
tissue:(9):Placenta
tissue:(10):Prostate
tissue:(11):Skeletal Muscle
tissue:(12):Spleen
tissue:(13):Testis
4:
[1]:
name:Fructose and mannose metabolism
smpdb_id:
kegg_map_id:map00051
[2]:
name:Fructose intolerance, hereditary
smpdb_id:SMP00725
kegg_map_id:
[3]:
name:Fructosuria
smpdb_id:SMP00561
kegg_map_id:
[4]:
name:Galactose Metabolism
smpdb_id:SMP00043
kegg_map_id:map00052
[5]:
name:Galactosemia
smpdb_id:SMP00182
kegg_map_id:
正常浓度
1:
biospecimen:Blood
concentration_value:39.0 +/- 7.0
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
2:
biospecimen:Blood
concentration_value:64.0 +/- 12.0
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
3:
biospecimen:Breast Milk
concentration_value:66.4 +/- 2.3
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Female
subject_condition:Normal
4:
biospecimen:Cerebrospinal Fluid (CSF)
concentration_value:64.0 (56.0-72.0)
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
5:
biospecimen:Cerebrospinal Fluid (CSF)
concentration_value:24 +/- 13
concentration_units:uM
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
6:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Infant (0-1 year old)
subject_sex:Both
subject_condition:Normal
7:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
8:
biospecimen:Feces
concentration_value:1010.236 +/- 542.863
concentration_units:nmol/g wet feces
subject_age:Not Specified
subject_sex:Not Specified
subject_condition:Normal
9:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
10:
biospecimen:Feces
concentration_value:
concentration_units:
subject_age:Not Specified
subject_sex:Not Specified
subject_condition:Normal
11:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
12:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
13:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
14:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
15:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
16:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
17:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
18:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
19:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
20:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Male
subject_condition:Normal
21:
biospecimen:Saliva
concentration_value:
concentration_units:
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
22:
biospecimen:Urine
concentration_value:2.357 +/- 0.311
concentration_units:umol/mmol creatinine
subject_age:Children (1 - 13 years old)
subject_sex:Not Specified
subject_condition:Normal
23:
biospecimen:Urine
concentration_value:11.65 +/- 15.42
concentration_units:umol/mmol creatinine
subject_age:Infant (0-1 year old)
subject_sex:Both
subject_condition:Normal
24:
biospecimen:Urine
concentration_value:2.5 (0.0-12.6)
concentration_units:umol/mmol creatinine
subject_age:Newborn (0-30 days old)
subject_sex:Both
subject_condition:Normal
25:
biospecimen:Urine
concentration_value:1.25 (0.0-2.5)
concentration_units:umol/mmol creatinine
subject_age:Adult (>18 years old)
subject_sex:Both
subject_condition:Normal
异常浓度
1:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Colorectal Cancer
2:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Colorectal cancer
3:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Adult (>18 years old)
patient_sex:Both
patient_information:Colorectal cancer
4:
biospecimen:Feces
concentration_value:
concentration_units:
patient_age:Children (1-13 years old)
patient_sex:Both
patient_information:Enthesitis-related arthritis
5:
biospecimen:Urine
concentration_value:23.466 +/- 26.455
concentration_units:umol/mmol creatinine
patient_age:Children (1 - 13 years old)
patient_sex:Not Specified
patient_information:Eosinophilic esophagitis
疾病参考
1:
name:Colorectal cancer
omim_id:114500
[1]:
reference_text:Ishiwata S, Itoh K, Yamaguchi T, Ishida N, Mizugaki M: Comparison of serum and urinary levels of modified nucleoside, 1-methyladenosine, in cancer patients using a monoclonal antibody-based inhibition ELISA. Tohoku J Exp Med. 1995 May;176(1):61-8.
pubmed_id:7482520
[2]:
reference_text:Monleon D, Morales JM, Barrasa A, Lopez JA, Vazquez C, Celda B: Metabolite profiling of fecal water extracts from human colorectal cancer. NMR Biomed. 2009 Apr;22(3):342-8. doi: 10.1002/nbm.1345.
pubmed_id:19006102
[3]:
reference_text:Weir TL, Manter DK, Sheflin AM, Barnett BA, Heuberger AL, Ryan EP: Stool microbiome and metabolome differences between colorectal cancer patients and healthy adults. PLoS One. 2013 Aug 6;8(8):e70803. doi: 10.1371/journal.pone.0070803. Print 2013.
pubmed_id:23940645
[4]:
reference_text:Phua LC, Chue XP, Koh PK, Cheah PY, Ho HK, Chan EC: Non-invasive fecal metabonomic detection of colorectal cancer. Cancer Biol Ther. 2014 Apr;15(4):389-97. doi: 10.4161/cbt.27625. Epub 2014 Jan 14.
pubmed_id:24424155
[5]:
reference_text:Ritchie SA, Ahiahonu PW, Jayasinghe D, Heath D, Liu J, Lu Y, Jin W, Kavianpour A, Yamazaki Y, Khan AM, Hossain M, Su-Myat KK, Wood PL, Krenitsky K, Takemasa I, Miyake M, Sekimoto M, Monden M, Matsubara H, Nomura F, Goodenowe DB: Reduced levels of hydroxylated, polyunsaturated ultra long-chain fatty acids in the serum of colorectal cancer patients: implications for early screening and detection. BMC Med. 2010 Feb 15;8:13. doi: 10.1186/1741-7015-8-13.
pubmed_id:20156336
[6]:
reference_text:Qiu Y, Cai G, Su M, Chen T, Zheng X, Xu Y, Ni Y, Zhao A, Xu LX, Cai S, Jia W: Serum metabolite profiling of human colorectal cancer using GC-TOFMS and UPLC-QTOFMS. J Proteome Res. 2009 Oct;8(10):4844-50. doi: 10.1021/pr9004162.
pubmed_id:19678709
[7]:
reference_text:Cheng Y, Xie G, Chen T, Qiu Y, Zou X, Zheng M, Tan B, Feng B, Dong T, He P, Zhao L, Zhao A, Xu LX, Zhang Y, Jia W: Distinct urinary metabolic profile of human colorectal cancer. J Proteome Res. 2012 Feb 3;11(2):1354-63. doi: 10.1021/pr201001a. Epub 2011 Dec 28.
pubmed_id:22148915
[8]:
reference_text:Ni Y, Xie G, Jia W: Metabonomics of human colorectal cancer: new approaches for early diagnosis and biomarker discovery. J Proteome Res. 2014 Sep 5;13(9):3857-70. doi: 10.1021/pr500443c. Epub 2014 Aug 14.
pubmed_id:25105552
[9]:
reference_text:Ikeda A, Nishiumi S, Shinohara M, Yoshie T, Hatano N, Okuno T, Bamba T, Fukusaki E, Takenawa T, Azuma T, Yoshida M: Serum metabolomics as a novel diagnostic approach for gastrointestinal cancer. Biomed Chromatogr. 2012 May;26(5):548-58. doi: 10.1002/bmc.1671. Epub 2011 Jul 20.
pubmed_id:21773981
[10]:
reference_text:Goedert JJ, Sampson JN, Moore SC, Xiao Q, Xiong X, Hayes RB, Ahn J, Shi J, Sinha R: Fecal metabolomics: assay performance and association with colorectal cancer. Carcinogenesis. 2014 Sep;35(9):2089-96. doi: 10.1093/carcin/bgu131. Epub 2014 Jul 18.
pubmed_id:25037050
[11]:
reference_text:Sinha R, Ahn J, Sampson JN, Shi J, Yu G, Xiong X, Hayes RB, Goedert JJ: Fecal Microbiota, Fecal Metabolome, and Colorectal Cancer Interrelations. PLoS One. 2016 Mar 25;11(3):e0152126. doi: 10.1371/journal.pone.0152126. eCollection 2016.
pubmed_id:27015276
[12]:
reference_text:Lin Y, Ma C, Liu C, Wang Z, Yang J, Liu X, Shen Z, Wu R: NMR-based fecal metabolomics fingerprinting as predictors of earlier diagnosis in patients with colorectal cancer. Oncotarget. 2016 May 17;7(20):29454-64. doi: 10.18632/oncotarget.8762.
pubmed_id:27107423
[13]:
reference_text:Brown DG, Rao S, Weir TL, O'Malia J, Bazan M, Brown RJ, Ryan EP: Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool. Cancer Metab. 2016 Jun 6;4:11. doi: 10.1186/s40170-016-0151-y. eCollection 2016.
pubmed_id:27275383
[14]:
reference_text:Wang X, Wang J, Rao B, Deng L: Gut flora profiling and fecal metabolite composition of colorectal cancer patients and healthy individuals. Exp Ther Med. 2017 Jun;13(6):2848-2854. doi: 10.3892/etm.2017.4367. Epub 2017 Apr 20.
pubmed_id:28587349
[15]:
reference_text:Silke Matysik, Caroline Ivanne Le Roy, Gerhard Liebisch, Sandrine Paule Claus. Metabolomics of fecal samples: A practical consideration. Trends in Food Science & Technology. Vol. 57, Part B, Nov. 2016, p.244-255: http://www.sciencedirect.com/science/article/pii/S0924224416301984
2:
name:Eosinophilic esophagitis
omim_id:610247
[1]:
reference_text:Mordechai, Hien, and David S. Wishart
pubmed_id:
综合参考
Sowden, John C.; Fischer, Hermann O. L. Condensation of nitromethane with D- and L-arabinose: preparation of L-glucose and L-mannose. Journal of the American Chemical Society (1947), 69 1963-5.
一般参考
1:
protein_accession:HMDBP00061
name:Phospholipase A2
uniprot_id:P04054
gene_name:PLA2G1B
protein_type:Unknown
2:
protein_accession:HMDBP00098
name:Prostatic acid phosphatase
uniprot_id:P15309
gene_name:ACPP
protein_type:Enzyme
3:
protein_accession:HMDBP00210
name:Glucokinase
uniprot_id:P35557
gene_name:GCK
protein_type:Enzyme
4:
protein_accession:HMDBP00212
name:Hexokinase-3
uniprot_id:P52790
gene_name:HK3
protein_type:Enzyme
5:
protein_accession:HMDBP00213
name:Hexokinase-2
uniprot_id:P52789
gene_name:HK2
protein_type:Enzyme
6:
protein_accession:HMDBP00215
name:Hexokinase-1
uniprot_id:P19367
gene_name:HK1
protein_type:Enzyme
7:
protein_accession:HMDBP00365
name:Lactase-phlorizin hydrolase
uniprot_id:P09848
gene_name:LCT
protein_type:Enzyme
8:
protein_accession:HMDBP00455
name:Deoxyribonuclease-1
uniprot_id:P24855
gene_name:DNASE1
protein_type:Unknown
9:
protein_accession:HMDBP00497
name:Liver carboxylesterase 1
uniprot_id:P23141
gene_name:CES1
protein_type:Enzyme
10:
protein_accession:HMDBP00525
name:Cholinesterase
uniprot_id:P06276
gene_name:BCHE
protein_type:Enzyme
11:
protein_accession:HMDBP00723
name:Alpha-galactosidase A
uniprot_id:P06280
gene_name:GLA
protein_type:Enzyme
12:
protein_accession:HMDBP00839
name:Beta-glucuronidase
uniprot_id:P08236
gene_name:GUSB
protein_type:Enzyme
13:
protein_accession:HMDBP00867
name:Alpha-mannosidase 2
uniprot_id:Q16706
gene_name:MAN2A1
protein_type:Unknown
14:
protein_accession:HMDBP00868
name:Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB
uniprot_id:O60476
gene_name:MAN1A2
protein_type:Unknown
15:
protein_accession:HMDBP00869
name:Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
uniprot_id:Q9UKM7
gene_name:MAN1B1
protein_type:Unknown
16:
protein_accession:HMDBP00870
name:Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA
uniprot_id:P33908
gene_name:MAN1A1
protein_type:Unknown
17:
protein_accession:HMDBP00928
name:Nitric oxide synthase, brain
uniprot_id:P29475
gene_name:NOS1
protein_type:Unknown
18:
protein_accession:HMDBP00976
name:Prostaglandin G/H synthase 1
uniprot_id:P23219
gene_name:PTGS1
protein_type:Unknown
19:
protein_accession:HMDBP01008
name:Polypeptide N-acetylgalactosaminyltransferase 1
uniprot_id:Q10472
gene_name:GALNT1
protein_type:Unknown
20:
protein_accession:HMDBP01188
name:Insulin-like growth factor 1 receptor
uniprot_id:P08069
gene_name:IGF1R
protein_type:Enzyme
21:
protein_accession:HMDBP01600
name:Lysozyme C
uniprot_id:P61626
gene_name:LYZ
protein_type:Enzyme
22:
protein_accession:HMDBP01604
name:Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
uniprot_id:Q92685
gene_name:ALG3
protein_type:Enzyme
23:
protein_accession:HMDBP01651
name:Dipeptidyl peptidase 4
uniprot_id:P27487
gene_name:DPP4
protein_type:Enzyme
24:
protein_accession:HMDBP01696
name:Cytokine receptor common subunit beta
uniprot_id:P32927
gene_name:CSF2RB
protein_type:Enzyme
25:
protein_accession:HMDBP01712
name:Heparin cofactor 2
uniprot_id:P05546
gene_name:SERPIND1
protein_type:Enzyme
26:
protein_accession:HMDBP01717
name:Beta-2-glycoprotein 1
uniprot_id:P02749
gene_name:APOH
protein_type:Enzyme
27:
protein_accession:HMDBP01724
name:Antithrombin-III
uniprot_id:P01008
gene_name:SERPINC1
protein_type:Enzyme
28:
protein_accession:HMDBP01754
name:Cation-independent mannose-6-phosphate receptor
uniprot_id:P11717
gene_name:IGF2R
protein_type:Enzyme
29:
protein_accession:HMDBP01980
name:Glycophorin-B
uniprot_id:P06028
gene_name:GYPB
protein_type:Enzyme
30:
protein_accession:HMDBP02009
name:Zinc-alpha-2-glycoprotein
uniprot_id:P25311
gene_name:AZGP1
protein_type:Enzyme
31:
protein_accession:HMDBP02010
name:Lactotransferrin
uniprot_id:P02788
gene_name:LTF
protein_type:Unknown
32:
protein_accession:HMDBP02065
name:Low-density lipoprotein receptor
uniprot_id:P01130
gene_name:LDLR
protein_type:Enzyme
33:
protein_accession:HMDBP02100
name:Rhodopsin
uniprot_id:P08100
gene_name:RHO
protein_type:Enzyme
34:
protein_accession:HMDBP02146
name:Alpha-amylase 2B
uniprot_id:P19961
gene_name:AMY2B
protein_type:Unknown
35:
protein_accession:HMDBP02285
name:Cathepsin D
uniprot_id:P07339
gene_name:CTSD
protein_type:Enzyme
36:
protein_accession:HMDBP02427
name:Galectin-1
uniprot_id:P09382
gene_name:LGALS1
protein_type:Enzyme
37:
protein_accession:HMDBP02570
name:Sialic acid-binding Ig-like lectin 7
uniprot_id:Q9Y286
gene_name:SIGLEC7
protein_type:Enzyme
38:
protein_accession:HMDBP02647
name:Mannose-binding protein C
uniprot_id:P11226
gene_name:MBL2
protein_type:Unknown
39:
protein_accession:HMDBP02728
name:Granzyme B
uniprot_id:P10144
gene_name:GZMB
protein_type:Enzyme
40:
protein_accession:HMDBP02780
name:CD209 antigen
uniprot_id:Q9NNX6
gene_name:CD209
protein_type:Unknown
41:
protein_accession:HMDBP02832
name:Interferon beta precursor
uniprot_id:P01574
gene_name:IFNB1
protein_type:Enzyme
42:
protein_accession:HMDBP05478
name:Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC
uniprot_id:Q9NR34
gene_name:MAN1C1
protein_type:Unknown
43:
protein_accession:HMDBP07480
name:Complement C1r subcomponent
uniprot_id:P00736
gene_name:C1R
protein_type:Unknown
44:
protein_accession:HMDBP08178
name:Atrial natriuretic peptide receptor 3
uniprot_id:P17342
gene_name:NPR3
protein_type:Unknown
45:
protein_accession:HMDBP09389
name:N-acetylglucosamine-1-phosphotransferase subunits alpha/beta
uniprot_id:Q3T906
gene_name:GNPTAB
protein_type:Enzyme
46:
protein_accession:HMDBP10017
name:Carboxypeptidase D
uniprot_id:O75976
gene_name:CPD
protein_type:Enzyme
47:
protein_accession:HMDBP11783
name:Putative hexokinase HKDC1
uniprot_id:Q2TB90
gene_name:HKDC1
protein_type:Unknown
48:
protein_accession:HMDBP11809
name:Alpha-mannosidase 2x
uniprot_id:P49641
gene_name:MAN2A2
protein_type:Unknown
49:
protein_accession:HMDBP11810
name:Lysosomal alpha-mannosidase
uniprot_id:O00754
gene_name:MAN2B1
protein_type:Unknown
50:
protein_accession:HMDBP11811
name:Epididymis-specific alpha-mannosidase
uniprot_id:Q9Y2E5
gene_name:MAN2B2
protein_type:Unknown
蛋白质结合
1:
reference_text:Wu X, Rush JS, Karaoglu D, Krasnewich D, Lubinsky MS, Waechter CJ, Gilmore R, Freeze HH: Deficiency of UDP-GlcNAc:Dolichol Phosphate N-Acetylglucosamine-1 Phosphate Transferase (DPAGT1) causes a novel congenital disorder of Glycosylation Type Ij. Hum Mutat. 2003 Aug;22(2):144-50.
pubmed_id:12872255
2:
reference_text:Thio CL, Mosbruger T, Astemborski J, Greer S, Kirk GD, O'Brien SJ, Thomas DL: Mannose binding lectin genotypes influence recovery from hepatitis B virus infection. J Virol. 2005 Jul;79(14):9192-6.
pubmed_id:15994813
3:
reference_text:Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762.
pubmed_id:19212411
4:
reference_text:Lee SH, Nam SY, Chung BC: Altered profile of endogenous steroids in the urine of patients with prolactinoma. Clin Biochem. 1998 Oct;31(7):529-35.
pubmed_id:9812172
5:
reference_text:Shoemaker JD, Elliott WH: Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease. J Chromatogr. 1991 Jan 2;562(1-2):125-38.
pubmed_id:2026685
6:
reference_text:Alton G, Hasilik M, Niehues R, Panneerselvam K, Etchison JR, Fana F, Freeze HH: Direct utilization of mannose for mammalian glycoprotein biosynthesis. Glycobiology. 1998 Mar;8(3):285-95.
pubmed_id:9451038
7:
reference_text:Nakagawa F, Schulte BA, Spicer SS: Lectin cytochemical evaluation of somatosensory neurons and their peripheral and central processes in rat and man. Cell Tissue Res. 1986;245(3):579-89.
pubmed_id:3757018
8:
reference_text:Otter M, Zockova P, Kuiper J, van Berkel TJ, Barrett-Bergshoeff MM, Rijken DC: Isolation and characterization of the mannose receptor from human liver potentially involved in the plasma clearance of tissue-type plasminogen activator. Hepatology. 1992 Jul;16(1):54-9.
pubmed_id:1618483
9:
reference_text:Hu P, Parenti G, Keulemans J, Hoogeveen AT: Lysosomal tartrate sensitive acid phosphatase deficiency in cells which contain lysosomal "high uptake forms". Biochem Biophys Res Commun. 1990 Mar 16;167(2):520-7.
pubmed_id:2322240
10:
reference_text:Hermentin P, Witzel R, Kanzy EJ, Diderrich G, Hoffmann D, Metzner H, Vorlop J, Haupt H: The hypothetical N-glycan charge: a number that characterizes protein glycosylation. Glycobiology. 1996 Mar;6(2):217-30.
pubmed_id:8727793
11:
reference_text:DeRossi C, Bode L, Eklund EA, Zhang F, Davis JA, Westphal V, Wang L, Borowsky AD, Freeze HH: Ablation of mouse phosphomannose isomerase (Mpi) causes mannose 6-phosphate accumulation, toxicity, and embryonic lethality. J Biol Chem. 2006 Mar 3;281(9):5916-27. Epub 2005 Dec 8.
pubmed_id:16339137
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reference_text:Miras MT, Aunis D, Mandel P: Studies on the interaction of dopamine beta-hydroxylase from various sources with phytohaemagglutinins. Clin Chim Acta. 1975 Nov 3;64(3):293-302.
pubmed_id:1183043
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reference_text:Van der Ploeg AT, Kroos MA, Willemsen R, Brons NH, Reuser AJ: Intravenous administration of phosphorylated acid alpha-glucosidase leads to uptake of enzyme in heart and skeletal muscle of mice. J Clin Invest. 1991 Feb;87(2):513-8.
pubmed_id:1991835
14:
reference_text:Cavallone D, Malagolini N, Monti A, Wu XR, Serafini-Cessi F: Variation of high mannose chains of Tamm-Horsfall glycoprotein confers differential binding to type 1-fimbriated Escherichia coli. J Biol Chem. 2004 Jan 2;279(1):216-22. Epub 2003 Oct 21.
pubmed_id:14570881
15:
reference_text:Adlerberth I, Ahrne S, Johansson ML, Molin G, Hanson LA, Wold AE: A mannose-specific adherence mechanism in Lactobacillus plantarum conferring binding to the human colonic cell line HT-29. Appl Environ Microbiol. 1996 Jul;62(7):2244-51.
pubmed_id:8779562
16:
reference_text:Hung CS, Bouckaert J, Hung D, Pinkner J, Widberg C, DeFusco A, Auguste CG, Strouse R, Langermann S, Waksman G, Hultgren SJ: Structural basis of tropism of Escherichia coli to the bladder during urinary tract infection. Mol Microbiol. 2002 May;44(4):903-15.
pubmed_id:12010488
17:
reference_text:Condaminet B, Peguet-Navarro J, Stahl PD, Dalbiez-Gauthier C, Schmitt D, Berthier-Vergnes O: Human epidermal Langerhans cells express the mannose-fucose binding receptor. Eur J Immunol. 1998 Nov;28(11):3541-51.
pubmed_id:9842897
18:
reference_text:Go S, Sato C, Furuhata K, Kitajima K: Oral ingestion of mannose alters the expression level of deaminoneuraminic acid (KDN) in mouse organs. Glycoconj J. 2006 Jul;23(5-6):411-21.
pubmed_id:16897182
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reference_text:Burk MR, Troeger C, Brinkhaus R, Holzgreve W, Hahn S: Severely reduced presence of tissue macrophages in the basal plate of pre-eclamptic placentae. Placenta. 2001 Apr;22(4):309-16.
pubmed_id:11286566
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reference_text:Sarkar K, Das PK: Protective effect of neoglycoprotein-conjugated muramyl dipeptide against Leishmania donovani infection: the role of cytokines. J Immunol. 1997 Jun 1;158(11):5357-65.
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reference_text:Kusmierz J, DeGeorge JJ, Sweeney D, May C, Rapoport SI: Quantitative analysis of polyols in human plasma and cerebrospinal fluid. J Chromatogr. 1989 Dec 29;497:39-48.
pubmed_id:2625478
22:
reference_text:Biessen EA, Noorman F, van Teijlingen ME, Kuiper J, Barrett-Bergshoeff M, Bijsterbosch MK, Rijken DC, van Berkel TJ: Lysine-based cluster mannosides that inhibit ligand binding to the human mannose receptor at nanomolar concentration. J Biol Chem. 1996 Nov 8;271(45):28024-30.
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23:
reference_text:Smith ME: Phagocytic properties of microglia in vitro: implications for a role in multiple sclerosis and EAE. Microsc Res Tech. 2001 Jul 15;54(2):81-94.
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reference_text:Della Porta M, Danova M, Rigolin GM, Brugnatelli S, Rovati B, Tronconi C, Fraulini C, Russo Rossi A, Riccardi A, Castoldi G: Dendritic cells and vascular endothelial growth factor in colorectal cancer: correlations with clinicobiological findings. Oncology. 2005;68(2-3):276-84. Epub 2005 Jul 7.
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reference_text:Patnaik SK, Stanley P: Mouse large can modify complex N- and mucin O-glycans on alpha-dystroglycan to induce laminin binding. J Biol Chem. 2005 May 27;280(21):20851-9. Epub 2005 Mar 23.
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reference_text:Brysk MM, Miller J: Concanavalin A binding glycoprotein in human stratum corneum. J Invest Dermatol. 1984 Mar;82(3):280-2.
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reference_text:Takahashi I, Takahashi T, Mikami T, Komatsu M, Ohura T, Schuchman EH, Takada G: Acid sphingomyelinase: relation of 93lysine residue on the ratio of intracellular to secreted enzyme activity. Tohoku J Exp Med. 2005 Aug;206(4):333-40.
pubmed_id:15997205
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reference_text:Akazawa S, Metzger BE, Freinkel N: Relationships between glucose and mannose during late gestation in normal pregnancy and pregnancy complicated by diabetes mellitus: concurrent concentrations in maternal plasma and amniotic fluid. J Clin Endocrinol Metab. 1986 May;62(5):984-9.
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reference_text:Blach-Olszewska Z: Innate immunity: cells, receptors, and signaling pathways. Arch Immunol Ther Exp (Warsz). 2005 May-Jun;53(3):245-53.
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reference_text:Pietila EM, Tuusa JT, Apaja PM, Aatsinki JT, Hakalahti AE, Rajaniemi HJ, Petaja-Repo UE: Inefficient maturation of the rat luteinizing hormone receptor. A putative way to regulate receptor numbers at the cell surface. J Biol Chem. 2005 Jul 15;280(28):26622-9. Epub 2005 May 18.
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reference_text:Carchon HA, Jaeken J: Determination of D-mannose in serum by capillary electrophoresis. Clin Chem. 2001;47(7):1319-21.
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32:
reference_text:Park SH, Pastuszak I, Drake R, Elbein AD: Purification to apparent homogeneity and properties of pig kidney L-fucose kinase. J Biol Chem. 1998 Mar 6;273(10):5685-91.
pubmed_id:9488699
33:
reference_text:Ito Y, Hagihara S, Matsuo I, Totani K: Structural approaches to the study of oligosaccharides in glycoprotein quality control. Curr Opin Struct Biol. 2005 Oct;15(5):481-9.
pubmed_id:16154739
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reference_text:Jack DL, Klein NJ, Turner MW: Mannose-binding lectin: targeting the microbial world for complement attack and opsonophagocytosis. Immunol Rev. 2001 Apr;180:86-99.
pubmed_id:11414367
35:
reference_text:Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043.
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reference_text:Sharma V, Ichikawa M, Freeze HH: Mannose metabolism: more than meets the eye. Biochem Biophys Res Commun. 2014 Oct 17;453(2):220-8. doi: 10.1016/j.bbrc.2014.06.021. Epub 2014 Jun 12.
pubmed_id:24931670
37:
reference_text:Klein T, Abgottspon D, Wittwer M, Rabbani S, Herold J, Jiang X, Kleeb S, Luthi C, Scharenberg M, Bezencon J, Gubler E, Pang L, Smiesko M, Cutting B, Schwardt O, Ernst B: FimH antagonists for the oral treatment of urinary tract infections: from design and synthesis to in vitro and in vivo evaluation. J Med Chem. 2010 Dec 23;53(24):8627-41. doi: 10.1021/jm101011y. Epub 2010 Nov 24.
pubmed_id:21105658