版本
5.0
创建日期
2005-11-16 15:48:42 UTC
更新日期
2021-09-14 15:19:00 UTC
登录号
HMDB0000167
地位
quantified
二级访问
HMDB00167

名称
L-Threonine
描述
Threonine (Thr) or L-threonine is an alpha-amino acid. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). Amino acids are organic compounds that contain amino (–NH2) and carboxyl (–COOH) functional groups, along with a side chain (R group) specific to each amino acid. L-threonine is one of 20 proteinogenic amino acids, i.e., the amino acids used in the biosynthesis of proteins. Threonine is found in all organisms ranging from bacteria to plants to animals. It is classified as a polar, uncharged (at physiological pH), aliphatic amino acid. Threonine is sometimes considered as a branched chain amino acid. Threonine was actually the last of the 20 amino acids to be discovered (in 1938). It was named threonine because it was similar in structure to threonic acid, a four-carbon monosaccharide. Threonine is an essential amino acid in humans, meaning the body cannot synthesize it and that it must be obtained from the diet. Foods high in threonine include cottage cheese, poultry, fish, meat, lentils, black turtle bean and sesame seeds. Adult humans require about 20 mg/kg body weight/day. In plants and microorganisms, threonine is synthesized from aspartic acid via alpha-aspartyl-semialdehyde and homoserine. In proteins, the threonine residue is susceptible to numerous posttranslational modifications. The hydroxyl side-chain can undergo O-linked glycosylation and phosphorylation through the action of a threonine kinase. Threonine is abundant in human plasma, particularly in newborns. Severe deficiency of threonine causes neurological dysfunction and lameness in experimental animals. Threonine is an immunostimulant which promotes the growth of thymus gland. It also can probably promote cell immune defense function. The threonine content of most of the infant formulas currently on the market is approximately 20% higher than the threonine concentration in human milk. Due to this high threonine content the plasma threonine concentrations are up to twice as high in premature infants fed these formulas than in infants fed human milk. The whey proteins which are used for infant formulas are sweet whey proteins. Sweet whey results from cheese production. Increasing the threonine plasma concentrations leads to accumulation of threonine and glycine in the brain. Such accumulation affects the neurotransmitter balance which may have consequences for the brain development during early postnatal life. Thus, excessive threonine intake during infant feeding should be avoided. (PMID 9853925). Threonine is metabolized in at least two ways. In many animals it is converted to pyruvate via threonine dehydrogenase. An intermediate in this pathway can undergo thiolysis with CoA to produce acetyl-CoA and glycine. In humans the gene for threonine dehydrogenase is an inactive pseudogene, so threonine is converted to alpha-ketobutyrate.
同义词
1:(2S)-Threonine

2:(2S,3R)-(-)-Threonine

3:(2S,3R)-2-Amino-3-hydroxybutanoic acid

4:2-Amino-3-hydroxybutyric acid

5:L-(-)-Threonine

6:L-2-Amino-3-hydroxybutyric acid

7:L-alpha-Amino-beta-hydroxybutyric acid

8:L-Threonin

9:T

10:Thr

11:THREONINE

12:(2S,3R)-2-Amino-3-hydroxybutanoate

13:2-Amino-3-hydroxybutyrate

14:L-2-Amino-3-hydroxybutyrate

15:L-a-Amino-b-hydroxybutyrate

16:L-a-Amino-b-hydroxybutyric acid

17:L-alpha-Amino-beta-hydroxybutyrate

18:L-Α-amino-β-hydroxybutyrate

19:L-Α-amino-β-hydroxybutyric acid

20:(2S,3R)-2-Amino-3-hydroxybutyrate

21:(2S,3R)-2-Amino-3-hydroxybutyric acid

22:(R-(R*,s*))-2-amino-3-hydroxybutanoate

23:(R-(R*,s*))-2-amino-3-hydroxybutanoic acid

24:(S)-Threonine

25:2-Amino-3-hydroxybutanoate

26:2-Amino-3-hydroxybutanoic acid

27:Threonin

28:[R-(R*,s*)]-2-amino-3-hydroxy-butanoate

29:[R-(R*,s*)]-2-amino-3-hydroxy-butanoic acid

30:[R-(R*,s*)]-2-amino-3-hydroxybutanoate

31:[R-(R*,s*)]-2-amino-3-hydroxybutanoic acid

32:L Threonine

化学式
C4H9NO3
平均分子量
119.1192
等位分子量
119.058243159
化学名称
(2S,3R)-2-amino-3-hydroxybutanoic acid
传统名称
L-threonine
CAS 登记号
72-19-5
代谢物结构字符串
C[C@@H](O)[C@H](N)C(O)=O
inchi标识符
InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1
印记键
AYFVYJQAPQTCCC-GBXIJSLDSA-N
分类学
description: belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.

description:L-alpha-amino acids

kingdom:Organic compounds

super_class:Organic acids and derivatives

class:Carboxylic acids and derivatives

sub_class:Amino acids, peptides, and analogues

molecular_framework:Aliphatic acyclic compounds

1:Amino acids

2:Beta hydroxy acids and derivatives

3:Carbonyl compounds

4:Carboxylic acids

5:Fatty acids and conjugates

6:Hydrocarbon derivatives

7:Monoalkylamines

8:Monocarboxylic acids and derivatives

9:Organic oxides

10:Organopnictogen compounds

11:Secondary alcohols

12:Short-chain hydroxy acids and derivatives

13:Alcohol

14:Aliphatic acyclic compound

15:Amine

16:Amino acid

17:Beta-hydroxy acid

18:Carbonyl group

19:Carboxylic acid

20:Fatty acid

21:Hydrocarbon derivative

22:Hydroxy acid

23:L-alpha-amino acid

24:Monocarboxylic acid or derivatives

25:Organic nitrogen compound

26:Organic oxide

27:Organic oxygen compound

28:Organonitrogen compound

29:Organooxygen compound

30:Organopnictogen compound

31:Primary aliphatic amine

32:Primary amine

33:Secondary alcohol

34:Short-chain hydroxy acid

35:Common amino acids

36:L-alpha-amino acid

37:aspartate family amino acid

38:proteinogenic amino acid

39:threonine

本体论
term:Physiological effect

definition:The effect on an organism physiology, resulting from its exposure to a chemical.

parent_id:

level:1

type:parent

term:Health effect

definition:A health condition or observation associated with a stimuli or with a biological activity of a chemical.

parent_id:7693

*level:2

type:parent

term:Observation

definition:A short term health effect which reflects the reponse of the body to stimuli or is a symptom of a disease or condition; also includes health status which reflects stage in life.

parent_id:7694

**level:3

type:parent

term:Attachment loss

definition:

parent_id:7717

***level:4

type:child

term:Missing teeth

definition:

parent_id:7717

***level:4

type:child

term:Periodontal Probing Depth

definition:

parent_id:7717

***level:4

type:child

term:Health condition

definition:A health effect that consists on short or long-term disease, condition, disorder, syndrome or constant abnormality.

parent_id:7694

**level:3

type:parent

term:Schizophrenia

definition:A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness. (do).

parent_id:7695

***level:4

type:child

term:Epilepsy

definition:A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions. (do).

parent_id:7695

***level:4

type:child

synonym:Epileptic spasms

term:Cardiac disorders

definition:Any disorder that affects the heart.

parent_id:7695

***level:4

type:parent

term:Cancer

definition:A group of disorders characterized by the presense of malignant neoplasm.

parent_id:7695

***level:4

type:parent

term:Disposition

definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.

parent_id:

level:1

type:parent

term:Route of exposure

definition:A mean by which a chemical agent comes in contact with an organism, either under intended or unintended circumstances.

parent_id:7724

*level:2

type:parent

term:Enteral

definition:Chemical exposure via the alimentary canal (mouth to anus).

parent_id:7743

**level:3

type:parent

term:Ingestion

definition:Chemical exposure facilitated by entry through the mouth.

parent_id:7744

***level:4

type:child

synonym:Digestion

term:Source

definition:Natural or synthetic origin of a chemical.

parent_id:7724

*level:2

type:parent

term:Food

definition:

parent_id:7735

**level:3

type:child

term:Synthetic

definition:A man-made product or sample in which a chemical can be found.

parent_id:7735

**level:3

type:parent

term:Personal care product

definition:

parent_id:7742

***level:4

type:child

synonym:Pcp

synonym:Toiletries

synonym:Toiletry

synonym:Personal hygiene

synonym:Beautification product

term:Biological

definition:A living organism (species or a higher taxonomy rank), in which a chemical can be found.

parent_id:7735

**level:3

type:parent

term:Animal

definition:A living organism belonging to the kingdom animalia. it feeds on organic matter, typically having specialized sense organs and nervous system and able to respond rapidly to stimuli.

parent_id:7736

***level:4

type:child

synonym:Fauna

term:Plant

definition:A living organism belonging to the kingdom plantea. typically, it grows in a permanent site, absorbs water and inorganic substances through its roots, and synthesizes nutrients in its leaves by photosynthesis using the green pigment chlorophyll. examples incude trees, shrubs, herbs, grasses, ferns, and mosses.

parent_id:7736

***level:4

type:parent

synonym:Flora

term:Biological location

definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.

parent_id:7724

*level:2

type:parent

term:Tissue and substructures

definition:An anatomical organizational level including multiple cells yet not comprising a complete organ .

parent_id:7725

**level:3

type:parent

term:All tissues

definition:All tissues in the body of the organism.

parent_id:7729

***level:4

type:child

term:Placenta

definition:An organ present in some vertebrates during embryonic gestation that surrounds the fetus and provides it with nutrients and oxygen, facilitates gas and waste exchange between the fetus and mother, and provides parasitic cloaking from the mother's immune system by excretion of neurokinin b. (nci).

parent_id:7729

***level:4

type:child

term:Organ and components

definition:An anatomical organizational level including multiple tissues or substructures, which enables a common biological function.

parent_id:7725

**level:3

type:parent

term:Prostate

definition:The male reproductive accessory gland that produces prostatic fluid and is located adjacent to or around the urethra distal to the urinary bladder in mammals. (nci).

parent_id:7727

***level:4

type:child

synonym:Prostate gland

term:Biofluid and excreta

definition:A liquid, semi-solid or solid material originating in the body.

parent_id:7725

**level:3

type:parent

term:Urine

definition:Excretion in liquid state processed by the kidney.

parent_id:7731

***level:4

type:child

term:Saliva

definition:The watery fluid in the mouth made by the salivary glands. saliva moistens food to help digestion and it helps protect the mouth against infections. (nci).

parent_id:7731

***level:4

type:child

term:Feces

definition:The material discharged from the bowel during defecation. It consists of undigested food, intestinal mucus, epithelial cells, and bacteria.

parent_id:7731

***level:4

type:child

synonym:Fecal

synonym:Stool

synonym:Faecal

synonym:Faeces

term:Blood

definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.

parent_id:7731

***level:4

type:child

term:Breast milk

definition:Portion of secreted substance produced by the mammary gland.

parent_id:7731

***level:4

type:child

term:Sweat

definition:Secretion produced by a sweat gland.

parent_id:7731

***level:4

type:child

term:Cerebrospinal fluid

definition:The fluid that is contained within the brain ventricles, the subarachnoid space and the central canal of the spinal cord. (nci).

parent_id:7731

***level:4

type:child

synonym:Csf

term:Subcellular

definition:An anatomical organizational level including a component within a biological cell .

parent_id:7725

**level:3

type:parent

term:Cytoplasm

definition:The portion of the cell contained within the plasma membrane but excluding the nucleus.

parent_id:7730

***level:4

type:child

synonym:Cytoplasma

term:Mitochondria

definition:

parent_id:7730

***level:4

type:child

term:Cell and elements

definition:An anatomical organizational level comprising of a single cell (or a fragment in some exceptions). a cell is defined by its type or function. it is the smallest unit of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid.

parent_id:7725

**level:3

type:parent

term:Extracellular

definition:The space external to the outermost structure of a cell.

parent_id:7732

***level:4

type:child

synonym:Extracellular region

term:Process

definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.

parent_id:

level:1

type:parent

term:Naturally occurring process

definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.

parent_id:7659

*level:2

type:parent

term:Biological process

definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.

parent_id:7660

**level:3

type:parent

term:Biochemical pathway

definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.

parent_id:7661

***level:4

type:parent

term:Role

definition:The purpose or function assumed by a chemical, either naturally or as intended by humans .

parent_id:

level:1

type:parent

term:Industrial application

definition:The assumed function of a chemical utilized by human.

parent_id:7671

*level:2

type:parent

term:Drug

definition:A chemical substance or preparation that causes a physiological effect in the body upon exposure .

parent_id:7678

**level:3

type:child

term:Personal care products

definition:Cosmetics and personal hygene products in which a chemical was incorportaed during the manufacturing process.

parent_id:7678

**level:3

type:child

term:Food and nutrition

definition:A chemical purpose related to manufacturing of food and nutrition products.

parent_id:7678

**level:3

type:parent

term:Nutritional supplement

definition:

parent_id:7687

***level:4

type:child

synonym:Nutraceutical

synonym:Dietary supplement

term:Pharmaceutical industry

definition:A pharmacologic activity for which a chemical substance is utilized owing to its biological role.

parent_id:7678

**level:3

type:parent

term:Pharmaceutical

definition:

parent_id:7679

***level:4

type:child

term:Biological role

definition:The biological function of a chemical. the biological role answers the question how a chemical is involved in molecular processes in an organism. this can include biochemical effects of non-endogenous chemicals, which are also assigned an industrial application such as pharmaceuticals. the biological role is limited to cellular levls, and will not include role at system process level, such as a chemical which has a role in a disease.

parent_id:7671

*level:2

type:parent

term:Essential amino acid

definition:

parent_id:7672

**level:3

type:child

term:Trace element

definition:A chemical element that occurs in very small amounts in organisms and is essential for many physiological and biochemical processes.В .

parent_id:7672

**level:3

type:child

synonym:Trace mineral

synonym:Essential mineral

状态
Solid
实验性质
1:

kind:water_solubility

value:97.0 mg/mL

source:

2:

kind:logp

value:-2.94

source:HANSCH,C ET AL. (1995)

3:

kind:melting_point

value:256 °C

source:

预测性质
1:

kind:logp

value:-3.01

source:ALOGPS

2:

kind:logs

value:0.60

source:ALOGPS

3:

kind:solubility

value:477 g/L

source:ALOGPS

4:

kind:logp

value:-3.5

source:ChemAxon

5:

kind:pka_strongest_acidic

value:2.21

source:ChemAxon

6:

kind:pka_strongest_basic

value:9

source:ChemAxon

7:

kind:iupac

value:(2S,3R)-2-amino-3-hydroxybutanoic acid

source:ChemAxon

8:

kind:average_mass

value:119.1192

source:ChemAxon

9:

kind:mono_mass

value:119.058243159

source:ChemAxon

10:

kind:smiles

value:C[C@@H](O)[C@H](N)C(O)=O

source:ChemAxon

11:

kind:formula

value:C4H9NO3

source:ChemAxon

12:

kind:inchi

value:InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1

source:ChemAxon

13:

kind:inchikey

value:AYFVYJQAPQTCCC-GBXIJSLDSA-N

source:ChemAxon

14:

kind:polar_surface_area

value:83.55

source:ChemAxon

15:

kind:refractivity

value:26.46

source:ChemAxon

16:

kind:polarizability

value:11.08

source:ChemAxon

17:

kind:rotatable_bond_count

value:2

source:ChemAxon

18:

kind:acceptor_count

value:4

source:ChemAxon

19:

kind:donor_count

value:3

source:ChemAxon

20:

kind:physiological_charge

value:0

source:ChemAxon

21:

kind:formal_charge

value:0

source:ChemAxon

22:

kind:number_of_rings

value:0

source:ChemAxon

23:

kind:bioavailability

value:Yes

source:ChemAxon

24:

kind:rule_of_five

value:Yes

source:ChemAxon

25:

kind:ghose_filter

value:No

source:ChemAxon

26:

kind:veber_rule

value:No

source:ChemAxon

27:

kind:mddr_like_rule

value:No

source:ChemAxon

1:

type:Specdb::NmrTwoD

spectrum_id:979

2:

type:Specdb::NmrTwoD

spectrum_id:1182

3:

type:Specdb::NmrOneD

spectrum_id:1129

4:

type:Specdb::NmrOneD

spectrum_id:1184

5:

type:Specdb::NmrOneD

spectrum_id:4794

6:

type:Specdb::NmrOneD

spectrum_id:142650

7:

type:Specdb::NmrOneD

spectrum_id:142651

8:

type:Specdb::NmrOneD

spectrum_id:142652

9:

type:Specdb::NmrOneD

spectrum_id:142653

10:

type:Specdb::NmrOneD

spectrum_id:142654

11:

type:Specdb::NmrOneD

spectrum_id:142655

12:

type:Specdb::NmrOneD

spectrum_id:142656

13:

type:Specdb::NmrOneD

spectrum_id:142657

14:

type:Specdb::NmrOneD

spectrum_id:142658

15:

type:Specdb::NmrOneD

spectrum_id:142659

16:

type:Specdb::NmrOneD

spectrum_id:142660

17:

type:Specdb::NmrOneD

spectrum_id:142661

18:

type:Specdb::NmrOneD

spectrum_id:142662

19:

type:Specdb::NmrOneD

spectrum_id:142663

20:

type:Specdb::NmrOneD

spectrum_id:142664

21:

type:Specdb::NmrOneD

spectrum_id:142665

22:

type:Specdb::NmrOneD

spectrum_id:142666

23:

type:Specdb::NmrOneD

spectrum_id:142667

24:

type:Specdb::NmrOneD

spectrum_id:142668

25:

type:Specdb::NmrOneD

spectrum_id:142669

26:

type:Specdb::NmrOneD

spectrum_id:166491

27:

type:Specdb::MsMs

spectrum_id:263

28:

type:Specdb::MsMs

spectrum_id:264

29:

type:Specdb::MsMs

spectrum_id:265

30:

type:Specdb::MsMs

spectrum_id:3258

31:

type:Specdb::MsMs

spectrum_id:3259

32:

type:Specdb::MsMs

spectrum_id:3260

33:

type:Specdb::MsMs

spectrum_id:3261

34:

type:Specdb::MsMs

spectrum_id:3262

35:

type:Specdb::MsMs

spectrum_id:3263

36:

type:Specdb::MsMs

spectrum_id:3264

37:

type:Specdb::MsMs

spectrum_id:3265

38:

type:Specdb::MsMs

spectrum_id:3266

39:

type:Specdb::MsMs

spectrum_id:3267

40:

type:Specdb::MsMs

spectrum_id:3268

41:

type:Specdb::MsMs

spectrum_id:3269

42:

type:Specdb::MsMs

spectrum_id:3270

43:

type:Specdb::MsMs

spectrum_id:3271

44:

type:Specdb::MsMs

spectrum_id:3272

45:

type:Specdb::MsMs

spectrum_id:3273

46:

type:Specdb::MsMs

spectrum_id:3274

47:

type:Specdb::MsMs

spectrum_id:3275

48:

type:Specdb::MsMs

spectrum_id:3276

49:

type:Specdb::MsMs

spectrum_id:3277

50:

type:Specdb::MsMs

spectrum_id:3278

51:

type:Specdb::MsMs

spectrum_id:178482

52:

type:Specdb::CMs

spectrum_id:399

53:

type:Specdb::CMs

spectrum_id:400

54:

type:Specdb::CMs

spectrum_id:1025

55:

type:Specdb::CMs

spectrum_id:1090

56:

type:Specdb::CMs

spectrum_id:2588

57:

type:Specdb::CMs

spectrum_id:30052

58:

type:Specdb::CMs

spectrum_id:30053

59:

type:Specdb::CMs

spectrum_id:30382

60:

type:Specdb::CMs

spectrum_id:30613

61:

type:Specdb::CMs

spectrum_id:30728

62:

type:Specdb::CMs

spectrum_id:31038

63:

type:Specdb::CMs

spectrum_id:31039

64:

type:Specdb::CMs

spectrum_id:37333

65:

type:Specdb::CMs

spectrum_id:170648

光谱
生物学性质
1:

cellular:(1):Cytoplasm

cellular:(2):Extracellular

2:

biospecimen:(1):Blood

biospecimen:(2):Breast Milk

biospecimen:(3):Cerebrospinal Fluid (CSF)

biospecimen:(4):Feces

biospecimen:(5):Saliva

biospecimen:(6):Sweat

biospecimen:(7):Urine

3:

tissue:(1):All Tissues

tissue:(2):Placenta

tissue:(3):Prostate

4:

[1]:

name:Amikacin Action Pathway

smpdb_id:SMP00253

kegg_map_id:

[2]:

name:Arbekacin Action Pathway

smpdb_id:SMP00713

kegg_map_id:

[3]:

name:Azithromycin Action Pathway

smpdb_id:SMP00247

kegg_map_id:

[4]:

name:Chloramphenicol Action Pathway

smpdb_id:SMP00729

kegg_map_id:

[5]:

name:Clarithromycin Action Pathway

smpdb_id:SMP00248

kegg_map_id:

[6]:

name:Clindamycin Action Pathway

smpdb_id:SMP00249

kegg_map_id:

[7]:

name:Clomocycline Action Pathway

smpdb_id:SMP00262

kegg_map_id:

[8]:

name:Demeclocycline Action Pathway

smpdb_id:SMP00290

kegg_map_id:

[9]:

name:Doxycycline Action Pathway

smpdb_id:SMP00291

kegg_map_id:

[10]:

name:Erythromycin Action Pathway

smpdb_id:SMP00250

kegg_map_id:

[11]:

name:Gentamicin Action Pathway

smpdb_id:SMP00254

kegg_map_id:

[12]:

name:Glycine, serine and threonine metabolism

smpdb_id:

kegg_map_id:map00260

[13]:

name:Josamycin Action Pathway

smpdb_id:SMP00731

kegg_map_id:

[14]:

name:Kanamycin Action Pathway

smpdb_id:SMP00255

kegg_map_id:

[15]:

name:Lincomycin Action Pathway

smpdb_id:SMP00728

kegg_map_id:

[16]:

name:Lymecycline Action Pathway

smpdb_id:SMP00295

kegg_map_id:

[17]:

name:Methacycline Action Pathway

smpdb_id:SMP00727

kegg_map_id:

[18]:

name:Minocycline Action Pathway

smpdb_id:SMP00292

kegg_map_id:

[19]:

name:Neomycin Action Pathway

smpdb_id:SMP00256

kegg_map_id:

[20]:

name:Netilmicin Action Pathway

smpdb_id:SMP00257

kegg_map_id:

[21]:

name:Oxytetracycline Action Pathway

smpdb_id:SMP00293

kegg_map_id:

[22]:

name:Paromomycin Action Pathway

smpdb_id:SMP00714

kegg_map_id:

[23]:

name:Rolitetracycline Action Pathway

smpdb_id:SMP00726

kegg_map_id:

[24]:

name:Roxithromycin Action Pathway

smpdb_id:SMP00251

kegg_map_id:

[25]:

name:Spectinomycin Action Pathway

smpdb_id:SMP00258

kegg_map_id:

[26]:

name:Streptomycin Action Pathway

smpdb_id:SMP00259

kegg_map_id:

[27]:

name:Telithromycin Action Pathway

smpdb_id:SMP00252

kegg_map_id:

[28]:

name:Tetracycline Action Pathway

smpdb_id:SMP00294

kegg_map_id:

[29]:

name:Threonine and 2-Oxobutanoate Degradation

smpdb_id:SMP00452

kegg_map_id:

[30]:

name:Tigecycline Action Pathway

smpdb_id:SMP00712

kegg_map_id:

[31]:

name:Tobramycin Action Pathway

smpdb_id:SMP00711

kegg_map_id:

[32]:

name:Transcription/Translation

smpdb_id:SMP00019

kegg_map_id:

[33]:

name:Troleandomycin Action Pathway

smpdb_id:SMP00730

kegg_map_id:

正常浓度
1:

biospecimen:Blood

concentration_value:127.7 +/- 41

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

2:

biospecimen:Blood

concentration_value:43-150

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

3:

biospecimen:Blood

concentration_value:47-150

concentration_units:uM

subject_age:Infant (1 - 3 months old)

subject_sex:Both

subject_condition:Normal

4:

biospecimen:Blood

concentration_value:40-300

concentration_units:uM

subject_age:Children (3 months - 6 years old)

subject_sex:Both

subject_condition:Normal

5:

biospecimen:Blood

concentration_value:74-250

concentration_units:uM

subject_age:Children (6 - 18 years old)

subject_sex:Both

subject_condition:Normal

6:

biospecimen:Blood

concentration_value:102.3 +/- 24.6

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

7:

biospecimen:Blood

concentration_value:140.0 (107.0-173.0)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

8:

biospecimen:Blood

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

9:

biospecimen:Blood

concentration_value:215.0 +/- 60.0

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Not Specified

subject_condition:Normal

10:

biospecimen:Blood

concentration_value:140.0 +/- 28.0

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Male

subject_condition:Normal

11:

biospecimen:Blood

concentration_value:146.0 +/- 22.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

12:

biospecimen:Blood

concentration_value:154.0 +/- 40.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

13:

biospecimen:Blood

concentration_value:<10

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Not Specified

subject_condition:Normal

14:

biospecimen:Blood

concentration_value:70-220

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Not Specified

subject_condition:Normal

15:

biospecimen:Blood

concentration_value:90-329

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

16:

biospecimen:Blood

concentration_value:126 +/- 7.44

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

17:

biospecimen:Blood

concentration_value:80.00-220.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

18:

biospecimen:Blood

concentration_value:127.9 +/- 28.2

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

19:

biospecimen:Blood

concentration_value:89.7(72.1-105.4)

concentration_units:uM

subject_age:Children (1-13 uears old)

subject_sex:Both

subject_condition:Normal

20:

biospecimen:Blood

concentration_value:260.0 +/- 10.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

21:

biospecimen:Breast Milk

concentration_value:96.5 +/- 31.4

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

22:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:32.0 (4.00-60.0)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

23:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:30 +/- 12

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

24:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:27.7 +/- 4.7

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

25:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:45.9 +/- 12.3

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

26:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:37.4 +/- 7.6

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

27:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:34.7 +/- 6.2

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

28:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:26.5 +/- 4.2

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

29:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:8-46

concentration_units:uM

subject_age:Children (0 - 10 years old)

subject_sex:Both

subject_condition:Normal

30:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:6.5-56

concentration_units:uM

subject_age:Adolescent (>11 years old)

subject_sex:Both

subject_condition:Normal

31:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:10.35 +/- 0.88

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

32:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

33:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Children (1-13 years old)

subject_sex:Both

subject_condition:Normal

34:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

35:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Not Specified

subject_sex:Both

subject_condition:Normal

36:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

37:

biospecimen:Feces

concentration_value:4309.409 (2770.334-5848.483)

concentration_units:nmol/g wet feces

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

38:

biospecimen:Feces

concentration_value:6212.265 (1063.361-11361.169)

concentration_units:nmol/g wet feces

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

39:

biospecimen:Feces

concentration_value:6771.928 (1846.890-11696.967)

concentration_units:nmol/g wet feces

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

40:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

41:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

42:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Children (6 - 18 years old)

subject_sex:Both

subject_condition:Normal

43:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Children (6 - 18 years old)

subject_sex:Not Specified

subject_condition:Normal

44:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

45:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

46:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

47:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

48:

biospecimen:Feces

concentration_value:320 +/- 220

concentration_units:nmol/g wet feces

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

49:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

50:

biospecimen:Feces

concentration_value:40 +/- 30

concentration_units:nmol/g wet feces

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

51:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

52:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

53:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

54:

biospecimen:Saliva

concentration_value:>10

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

55:

biospecimen:Saliva

concentration_value:7.78 +/- 13.5

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

56:

biospecimen:Saliva

concentration_value:7.98 +/- 7.32

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

57:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

58:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

59:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

60:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

61:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

62:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

63:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

64:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

65:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

66:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

67:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

68:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

69:

biospecimen:Saliva

concentration_value:<0.25

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

70:

biospecimen:Saliva

concentration_value:<0.25

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

71:

biospecimen:Saliva

concentration_value:3.7 +/- 3.6

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

72:

biospecimen:Saliva

concentration_value:3.50 +/- 4.89

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

73:

biospecimen:Saliva

concentration_value:26.75 +/- 28.12

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

74:

biospecimen:Saliva

concentration_value:3.96 +/- 2.50

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

75:

biospecimen:Saliva

concentration_value:3.7 +/- 0.45

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

76:

biospecimen:Saliva

concentration_value:6.27 +/- 3.07

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

77:

biospecimen:Sweat

concentration_value:< 10

concentration_units:uM

subject_age:Adult (60 years old)

subject_sex:Male

subject_condition:Normal

78:

biospecimen:Sweat

concentration_value:< 10

concentration_units:uM

subject_age:Adult (40 years old)

subject_sex:Male

subject_condition:Normal

79:

biospecimen:Urine

concentration_value:2.83-51.58

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

80:

biospecimen:Urine

concentration_value:10.3

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

81:

biospecimen:Urine

concentration_value:4.19-47.28

concentration_units:umol/mmol creatinine

subject_age:Adolescent (13-18 years old)

subject_sex:Not Specified

subject_condition:Normal

82:

biospecimen:Urine

concentration_value:8.40-100.79

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

83:

biospecimen:Urine

concentration_value:36.20 +/- 25.38

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

84:

biospecimen:Urine

concentration_value:3.51-31.45

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

85:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

86:

biospecimen:Urine

concentration_value:6.8-14

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

87:

biospecimen:Urine

concentration_value:2.58-81.52

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Female

subject_condition:Normal

88:

biospecimen:Urine

concentration_value:2.83-137.64

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

89:

biospecimen:Urine

concentration_value:0.58-73.49

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Male

subject_condition:Normal

90:

biospecimen:Urine

concentration_value:23.47 +/- 23.89

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Male

subject_condition:Normal

91:

biospecimen:Urine

concentration_value:24.64 +/- 21.56

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Female

subject_condition:Normal

92:

biospecimen:Urine

concentration_value:25.02 +/- 18.68

concentration_units:umol/mmol creatinine

subject_age:Children (0-2 years old)

subject_sex:Female

subject_condition:Normal

93:

biospecimen:Urine

concentration_value:26.48 +/- 21.33

concentration_units:umol/mmol creatinine

subject_age:Children (0-2 years old)

subject_sex:Male

subject_condition:Normal

94:

biospecimen:Urine

concentration_value:13.3 (6.4-25.2)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

95:

biospecimen:Urine

concentration_value:25.712 +/- 16.04

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

96:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

97:

biospecimen:Urine

concentration_value:2.8 +/- 1.3

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

98:

biospecimen:Urine

concentration_value:2.9 +/- 1.2

concentration_units:umol/mmol creatinine

subject_age:Infant (6 months - <1 year old)

subject_sex:Both

subject_condition:Normal

99:

biospecimen:Urine

concentration_value:3.1 +/- 1.1

concentration_units:umol/mmol creatinine

subject_age:Infant (1 - 6 months old)

subject_sex:Both

subject_condition:Normal

100:

biospecimen:Urine

concentration_value:14.0194-126.401

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

101:

biospecimen:Urine

concentration_value:6.22-86.31

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

102:

biospecimen:Urine

concentration_value:20.24 - 126.97

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

103:

biospecimen:Urine

concentration_value:17.41 - 85.36

concentration_units:umol/mmol creatinine

subject_age:Infant (1 - 6 months old)

subject_sex:Both

subject_condition:Normal

104:

biospecimen:Urine

concentration_value:14.81 - 52.80

concentration_units:umol/mmol creatinine

subject_age:Infant (6 months - <1 year old)

subject_sex:Both

subject_condition:Normal

105:

biospecimen:Urine

concentration_value:15.72 - 58.23

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 2 years old)

subject_sex:Both

subject_condition:Normal

106:

biospecimen:Urine

concentration_value:11.08 - 45.56

concentration_units:umol/mmol creatinine

subject_age:Children (2 - 4 years old)

subject_sex:Both

subject_condition:Normal

107:

biospecimen:Urine

concentration_value:9.38 - 34.60

concentration_units:umol/mmol creatinine

subject_age:Children (4 - 13 years old)

subject_sex:Both

subject_condition:Normal

108:

biospecimen:Urine

concentration_value:7.01 - 29.06

concentration_units:umol/mmol creatinine

subject_age:Adolescent (13 - 21 years old)

subject_sex:Both

subject_condition:Normal

109:

biospecimen:Urine

concentration_value:8.48 - 28.38

concentration_units:umol/mmol creatinine

subject_age:Adult (>21 years old)

subject_sex:Both

subject_condition:Normal

110:

biospecimen:Urine

concentration_value:5.17-24.59

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

111:

biospecimen:Urine

concentration_value:14.6 (6.6-29.3)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

112:

biospecimen:Urine

concentration_value:1.0 (0.16-2.4)

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

113:

biospecimen:Urine

concentration_value:4.9 +/- 2.5

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Female

subject_condition:Normal

114:

biospecimen:Urine

concentration_value:18.0 +/- 9.6

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

115:

biospecimen:Urine

concentration_value:16.0 +/- 9.0

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

116:

biospecimen:Urine

concentration_value:15-136

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

117:

biospecimen:Urine

concentration_value:3.39-62.67

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

118:

biospecimen:Urine

concentration_value:11-20

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

119:

biospecimen:Urine

concentration_value:316.57 +/- 260.04

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

120:

biospecimen:Urine

concentration_value:12.7 (4.934-20.4)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

121:

biospecimen:Urine

concentration_value:542.69 +/- 350.49

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

122:

biospecimen:Urine

concentration_value:814.03 +/- 587.91

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

123:

biospecimen:Urine

concentration_value:13.4

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

124:

biospecimen:Urine

concentration_value:9.24-96.17

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

125:

biospecimen:Urine

concentration_value:34.7611 +/- 13.8297

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

126:

biospecimen:Urine

concentration_value:25.44(15.16-69.43)

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Female

subject_condition:Normal

127:

biospecimen:Urine

concentration_value:30.69(9.10-99.45)

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Male

subject_condition:Normal

异常浓度
1:

biospecimen:Blood

concentration_value:73.8 +/- 29.5

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Obesity

2:

biospecimen:Blood

concentration_value:84.5 +/- 28.8

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Obesity

3:

biospecimen:Blood

concentration_value:83.4 +/- 47.8

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Heart Transplant

4:

biospecimen:Blood

concentration_value:114.0 +/- 9.2

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Epilepsy

5:

biospecimen:Blood

concentration_value:118.0 +/- 3.8

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Epilepsy

6:

biospecimen:Blood

concentration_value:104.34 +/- 48.09

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy with fetuses with trisomy 18

7:

biospecimen:Blood

concentration_value:108.80 +/- 42.53

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

8:

biospecimen:Blood

concentration_value:127.1 (29.0)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Early preeclampsia

9:

biospecimen:Blood

concentration_value:145.9 (60.3)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

10:

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

11:

biospecimen:Blood

concentration_value:414-681

concentration_units:uM

patient_age:Newborn (0-30 days old)

patient_sex:Both

patient_information:Citrullinemia type II, neonatal-onset

12:

biospecimen:Blood

concentration_value:53-542

concentration_units:uM

patient_age:Newborn (0-30 days old)

patient_sex:Both

patient_information:Pyridoxamine 5-prime-phosphate oxidase deficiency

13:

biospecimen:Blood

concentration_value:112.57 (25.66)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy with fetus having congenital heart defect

14:

biospecimen:Blood

concentration_value:107.31 (26.21)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

15:

biospecimen:Blood

concentration_value:313

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Male

patient_information:Fumaric aciduria

16:

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

17:

biospecimen:Blood

concentration_value:133.92(29.45)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Heart failure with preserved ejection fraction

18:

biospecimen:Blood

concentration_value:157.2 (60.2)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Late-onset preeclampsia

19:

biospecimen:Blood

concentration_value:166.2 (62.5)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

20:

biospecimen:Blood

concentration_value:111 +/- 10.3

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Schizophrenia

21:

biospecimen:Blood

concentration_value:89.1(69.6-118.1)

concentration_units:uM

patient_age:Children (1-13 uears old)

patient_sex:Both

patient_information:Environmental enteric dysfunction

22:

biospecimen:Blood

concentration_value:227.0 +/- 10.0

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Heart failure

23:

biospecimen:Blood

concentration_value:123.3 (31.8)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Down syndrome pregnancy

24:

biospecimen:Blood

concentration_value:119.3 (45.2)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

25:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:41.0 +/- 15.9

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Not Specified

patient_information:Leukemia

26:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:30.2 +/- 9.8

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Not Specified

patient_information:Leukemia

27:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:9.68 +/- 2.22

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Schizophrenia

28:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal Cancer

29:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

30:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Autism

31:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

32:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:ankylosing spondylitis

33:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:rheumatoid arthritis

34:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Both

patient_information:Crohns disease

35:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Both

patient_information:Ulcerative colitis

36:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Crohns disease

37:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Ulcerative colitis

38:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Unclassified IBD

39:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Myalgic encephalomyelitis/chronic fatigue syndrome

40:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

41:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Irritable bowel syndrome

42:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Ulcerative colitis

43:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

44:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Crohn's disease

45:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

46:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Attachment loss 

47:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Missing teeth

48:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Periodontal Probing Depth

49:

biospecimen:Saliva

concentration_value:3.65 +/- 0.97

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Alzheimer's disease

50:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Oral cancer

51:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Breast cancer

52:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Not Specified

patient_information:Pancreatic cancer

53:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Not Specified

patient_information:Periodontal diseases

54:

biospecimen:Saliva

concentration_value:4.36 +/- 1.21

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Frontotemporal lobe dementia

55:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Oral squamous cell carcinoma (OSCC)

56:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Oral leukoplakia (OLK)

57:

biospecimen:Saliva

concentration_value:5.83 +/- 3.11

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Lewy body disease

58:

biospecimen:Urine

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Bladder cancer

59:

biospecimen:Urine

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Autosomal dominant polycystic kidney disease (ADPKD)

60:

biospecimen:Urine

concentration_value:29.908 +/- 30.918

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Eosinophilic esophagitis

61:

biospecimen:Urine

concentration_value:226.200-1060

concentration_units:umol/mmol creatinine

patient_age:Infant (0-1 year old)

patient_sex:Not Specified

patient_information:Fumaric aciduria

62:

biospecimen:Urine

concentration_value:0.03 +/- 0.003

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Alzheimer's disease

63:

biospecimen:Urine

concentration_value:29.5912 +/- 12.5053

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Eosinophilic esophagitis

64:

biospecimen:Urine

concentration_value:23.4612 +/- 14.2639

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Gastroesophageal reflux disease

疾病参考
1:

name:Epilepsy

omim_id:

[1]:

reference_text:Rainesalo S, Keranen T, Palmio J, Peltola J, Oja SS, Saransaari P: Plasma and cerebrospinal fluid amino acids in epileptic patients. Neurochem Res. 2004 Jan;29(1):319-24.

pubmed_id:14992292

[2]:

reference_text:Cady EB, Lorek A, Penrice J, Reynolds EO, Iles RA, Burns SP, Coutts GA, Cowan FM: Detection of propan-1,2-diol in neonatal brain by in vivo proton magnetic resonance spectroscopy. Magn Reson Med. 1994 Dec;32(6):764-7.

pubmed_id:7869898

[3]:

reference_text:Perosa SR, Porcionatto MA, Cukiert A, Martins JR, Amado D, Nader HB, Cavalheiro EA, Leite JP, Naffah-Mazzacoratti MG: Extracellular matrix components are altered in the hippocampus, cortex, and cerebrospinal fluid of patients with mesial temporal lobe epilepsy. Epilepsia. 2002;43 Suppl 5:159-61.

pubmed_id:12121313

[4]:

reference_text:Spanaki MV, Siegel H, Kopylev L, Fazilat S, Dean A, Liow K, Ben-Menachem E, Gaillard WD, Theodore WH: The effect of vigabatrin (gamma-vinyl GABA) on cerebral blood flow and metabolism. Neurology. 1999 Oct 22;53(7):1518-22.

pubmed_id:10534261

[5]:

reference_text:Rating D, Siemes H, Loscher W: Low CSF GABA concentration in children with febrile convulsions, untreated epilepsy, and meningitis. J Neurol. 1983;230(4):217-25.

pubmed_id:6198481

[6]:

reference_text:Botez MI, Young SN: Effects of anticonvulsant treatment and low levels of folate and thiamine on amine metabolites in cerebrospinal fluid. Brain. 1991 Feb;114 ( Pt 1A):333-48.

pubmed_id:1705463

[7]:

reference_text:Kobayashi K, Koide Y, Yoshino K, Shohmori T: [P-hydroxyphenylacetic acid concentrations in cerebrospinal fluid]. No To Shinkei. 1982 Aug;34(8):769-74.

pubmed_id:7126379

[8]:

reference_text:Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90.

pubmed_id:15993662

[9]:

reference_text:Shaywitz BA, Cohen DJ, Bowers MB: Reduced cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in children with epilepsy. Neurology. 1975 Jan;25(1):72-9.

pubmed_id:803305

[10]:

reference_text:Anagnostouli M, Livaniou E, Nyalala JO, Evangelatos G, Zournas C, Ithakissios DS, Papageorgiou C: Cerebrospinal fluid levels of biotin in various neurological disorders. Acta Neurol Scand. 1999 Jun;99(6):387-92.

pubmed_id:10577274

[11]:

reference_text:Romigi A, Bari M, Placidi F, Marciani MG, Malaponti M, Torelli F, Izzi F, Prosperetti C, Zannino S, Corte F, Chiaramonte C, Maccarrone M: Cerebrospinal fluid levels of the endocannabinoid anandamide are reduced in patients with untreated newly diagnosed temporal lobe epilepsy. Epilepsia. 2010 May;51(5):768-72. doi: 10.1111/j.1528-1167.2009.02334.x. Epub 2009 Oct 8.

pubmed_id:19817812

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reference_text:Hirai K, Seki T: Cerebrospinal fluid somatostatin levels in febrile seizures and epilepsy in children. Neuropeptides. 2000 Feb;34(1):18-24.

pubmed_id:10688964

[13]:

reference_text:Peters JG: Dopamine, noradrenaline and serotonin spinal fluid metabolites in temporal lobe epileptic patients with schizophrenic symptomatology. Eur Neurol. 1979;18(1):15-8.

pubmed_id:436860

2:

name:Heart failure

omim_id:

[1]:

reference_text:Norrelund H, Wiggers H, Halbirk M, Frystyk J, Flyvbjerg A, Botker HE, Schmitz O, Jorgensen JO, Christiansen JS, Moller N: Abnormalities of whole body protein turnover, muscle metabolism and levels of metabolic hormones in patients with chronic heart failure. J Intern Med. 2006 Jul;260(1):11-21.

pubmed_id:16789974

[2]:

reference_text:Ferreira A, Bettencourt P, Pestana M, Correia F, Serrao P, Martins L, Cerqueira-Gomes M, Soares-Da-Silva P: Heart failure, aging, and renal synthesis of dopamine. Am J Kidney Dis. 2001 Sep;38(3):502-9.

pubmed_id:11532681

[3]:

reference_text:Adams KF Jr, Gheorghiade M, Uretsky BF, Patterson JH, Schwartz TA, Young JB: Clinical benefits of low serum digoxin concentrations in heart failure. J Am Coll Cardiol. 2002 Mar 20;39(6):946-53.

pubmed_id:11897434

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reference_text:Bhagavan HN, Chopra RK: Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion. 2007 Jun;7 Suppl:S78-88. Epub 2007 Mar 27.

pubmed_id:17482886

[5]:

reference_text:Kang SM, Park JC, Shin MJ, Lee H, Oh J, Ryu DH, Hwang GS, Chung JH: (1)H nuclear magnetic resonance based metabolic urinary profiling of patients with ischemic heart failure. Clin Biochem. 2011 Mar;44(4):293-9. doi: 10.1016/j.clinbiochem.2010.11.010. Epub 2010 Dec 15.

pubmed_id:21167146

3:

name:Early preeclampsia

omim_id:

[1]:

reference_text:Bahado-Singh RO, Akolekar R, Mandal R, Dong E, Xia J, Kruger M, Wishart DS, Nicolaides K: Metabolomics and first-trimester prediction of early-onset preeclampsia. J Matern Fetal Neonatal Med. 2012 Oct;25(10):1840-7. doi: 10.3109/14767058.2012.680254. Epub 2012 Apr 28.

pubmed_id:22494326

4:

name:Pregnancy

omim_id:

[1]:

reference_text:Yang XL, Wu XR: The dynamic changes of several reproductive hormones during termination of early pregnancy by RU486 in combination with PG-05 in Chinese women. Adv Contracept. 1988 Dec;4(4):319-26.

pubmed_id:3252730

[2]:

reference_text:Ball P, Emons G, Haupt O, Hoppen HO, Knuppen R: Radioimmunoassay of 2-hydroxyestrone. Steroids. 1978 Feb;31(2):249-58.

pubmed_id:663967

[3]:

reference_text:Yang YJ, Lee J, Choi MH, Chung BC: Direct determination of estriol 3- and 16-glucuronides in pregnancy urine by column-switching liquid chromatography with electrospray tandem mass spectrometry. Biomed Chromatogr. 2003 Jun;17(4):219-25.

pubmed_id:12833386

[4]:

reference_text:Andreolini F, Borra C, Caccamo F, Di Corcia A, Nicoletti I, Samperi R, Improta F: Estriol and its conjugates in late pregnancy determined by extraction with Carbopack B and liquid chromatography with fluorometric detection. Clin Chem. 1985 Oct;31(10):1698-702.

pubmed_id:2994907

[5]:

reference_text:Huang PC, Kuo PL, Guo YL, Liao PC, Lee CC: Associations between urinary phthalate monoesters and thyroid hormones in pregnant women. Hum Reprod. 2007 Oct;22(10):2715-22. Epub 2007 Aug 17.

pubmed_id:17704099

[6]:

reference_text:Ribar S, Mesaric M, Sedic M: Sphingoid bases as possible diagnostic parameters. Croat Med J. 2003 Apr;44(2):165-70.

pubmed_id:12698507

[7]:

reference_text:Khan HA, Sobki SH, Alhomida AS: Fluctuations in fasting blood glucose and serum fructosamine in pregnant women monitored on successive antenatal visits. Clin Exp Med. 2006 Oct;6(3):134-7.

pubmed_id:17061063

[8]:

reference_text:Mikkelsen TB, Osler M, Olsen SF: Validity of protein, retinol, folic acid and n-3 fatty acid intakes estimated from the food-frequency questionnaire used in the Danish National Birth Cohort. Public Health Nutr. 2006 Sep;9(6):771-8.

pubmed_id:16925883

[9]:

reference_text:Shiraishi M, Haruna M, Matsuzaki M, Murayama R, Sasaki S, Murashima S: Validity and reproducibility of folate and vitamin B(12) intakes estimated from a self-administered diet history questionnaire in Japanese pregnant women. Nutr J. 2012 Mar 15;11:15. doi: 10.1186/1475-2891-11-15.

pubmed_id:22420377

[10]:

reference_text:Brantsaeter AL, Haugen M, Julshamn K, Alexander J, Meltzer HM: Evaluation of urinary iodine excretion as a biomarker for intake of milk and dairy products in pregnant women in the Norwegian Mother and Child Cohort Study (MoBa). Eur J Clin Nutr. 2009 Mar;63(3):347-54. Epub 2007 Dec 5.

pubmed_id:18059417

[11]:

reference_text:Bahado-Singh RO, Akolekar R, Mandal R, Dong E, Xia J, Kruger M, Wishart DS, Nicolaides K: Metabolomics and first-trimester prediction of early-onset preeclampsia. J Matern Fetal Neonatal Med. 2012 Oct;25(10):1840-7. doi: 10.3109/14767058.2012.680254. Epub 2012 Apr 28.

pubmed_id:22494326

[12]:

reference_text:Bahado-Singh RO, Akolekar R, Mandal R, Dong E, Xia J, Kruger M, Wishart DS, Nicolaides K: First-trimester metabolomic detection of late-onset preeclampsia. Am J Obstet Gynecol. 2013 Jan;208(1):58.e1-7. doi: 10.1016/j.ajog.2012.11.003. Epub 2012 Nov 13.

pubmed_id:23159745

[13]:

reference_text:Bahado-Singh RO, Akolekar R, Mandal R, Dong E, Xia J, Kruger M, Wishart DS, Nicolaides K: Metabolomic analysis for first-trimester Down syndrome prediction. Am J Obstet Gynecol. 2013 May;208(5):371.e1-8. doi: 10.1016/j.ajog.2012.12.035. Epub 2013 Jan 8.

pubmed_id:23313728

[14]:

reference_text:Bahado-Singh RO, Akolekar R, Chelliah A, Mandal R, Dong E, Kruger M, Wishart DS, Nicolaides K: Metabolomic analysis for first-trimester trisomy 18 detection. Am J Obstet Gynecol. 2013 Jul;209(1):65.e1-9. doi: 10.1016/j.ajog.2013.03.028. Epub 2013 Mar 25.

pubmed_id:23535240

[15]:

reference_text:Bahado-Singh RO, Ertl R, Mandal R, Bjorndahl TC, Syngelaki A, Han B, Dong E, Liu PB, Alpay-Savasan Z, Wishart DS, Nicolaides KH: Metabolomic prediction of fetal congenital heart defect in the first trimester. Am J Obstet Gynecol. 2014 Sep;211(3):240.e1-240.e14. doi: 10.1016/j.ajog.2014.03.056. Epub 2014 Apr 1.

pubmed_id:24704061

[16]:

reference_text:The Merck Manual, 17th ed. Mark H. Beers, MD, Robert Berkow, MD, eds. Whitehouse Station, NJ: Merck Research Labs, 1999.

pubmed_id:

5:

name:Late-onset preeclampsia

omim_id:

[1]:

reference_text:Bahado-Singh RO, Akolekar R, Mandal R, Dong E, Xia J, Kruger M, Wishart DS, Nicolaides K: First-trimester metabolomic detection of late-onset preeclampsia. Am J Obstet Gynecol. 2013 Jan;208(1):58.e1-7. doi: 10.1016/j.ajog.2012.11.003. Epub 2012 Nov 13.

pubmed_id:23159745

6:

name:Fumarase deficiency

omim_id:606812

[1]:

reference_text:Bastug O, Kardas F, Ozturk MA, Halis H, Memur S, Korkmaz L, Tag Z, Gunes T: A rare cause of opistotonus; fumaric aciduria: The first case presentation in Turkey. Turk Pediatri Ars. 2014 Mar 1;49(1):74-6. doi: 10.5152/tpa.2014.442. eCollection 2014 Mar.

pubmed_id:26078636

[2]:

reference_text:Allegri G, Fernandes MJ, Scalco FB, Correia P, Simoni RE, Llerena JC Jr, de Oliveira ML: Fumaric aciduria: an overview and the first Brazilian case report. J Inherit Metab Dis. 2010 Aug;33(4):411-9. doi: 10.1007/s10545-010-9134-2. Epub 2010 Jun 15.

pubmed_id:20549362

[3]:

reference_text:Tregoning S, Salter W, Thorburn DR, Durkie M, Panayi M, Wu JY, Easterbrook A, Coman DJ: Fumarase deficiency in dichorionic diamniotic twins. Twin Res Hum Genet. 2013 Dec;16(6):1117-20. doi: 10.1017/thg.2013.72. Epub 2013 Nov 4.

pubmed_id:24182348

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reference_text:Linnebank M, Popp J, Smulders Y, Smith D, Semmler A, Farkas M, Kulic L, Cvetanovska G, Blom H, Stoffel-Wagner B, Kolsch H, Weller M, Jessen F: S-adenosylmethionine is decreased in the cerebrospinal fluid of patients with Alzheimer's disease. Neurodegener Dis. 2010;7(6):373-8. doi: 10.1159/000309657. Epub 2010 Jun 3.

pubmed_id:20523031

[22]:

reference_text:Rosler N, Wichart I, Jellinger KA: Clinical significance of neurobiochemical profiles in the lumbar cerebrospinal fluid of Alzheimer's disease patients. J Neural Transm (Vienna). 2001;108(2):231-46.

pubmed_id:11314776

[23]:

reference_text:Sunderland T, Berrettini WH, Molchan SE, Lawlor BA, Martinez RA, Vitiello B, Tariot PN, Cohen RM: Reduced cerebrospinal fluid dynorphin A1-8 in Alzheimer's disease. Biol Psychiatry. 1991 Jul 1;30(1):81-7.

pubmed_id:1716470

[24]:

reference_text:Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6.

pubmed_id:23857558

27:

name:Autosomal dominant polycystic kidney disease

omim_id:601313

[1]:

reference_text:Wang D, Strandgaard S, Borresen ML, Luo Z, Connors SG, Yan Q, Wilcox CS: Asymmetric dimethylarginine and lipid peroxidation products in early autosomal dominant polycystic kidney disease. Am J Kidney Dis. 2008 Feb;51(2):184-91. doi: 10.1053/j.ajkd.2007.09.020.

pubmed_id:18215696

[2]:

reference_text:Gronwald W, Klein MS, Zeltner R, Schulze BD, Reinhold SW, Deutschmann M, Immervoll AK, Boger CA, Banas B, Eckardt KU, Oefner PJ: Detection of autosomal dominant polycystic kidney disease by NMR spectroscopic fingerprinting of urine. Kidney Int. 2011 Jun;79(11):1244-53. doi: 10.1038/ki.2011.30. Epub 2011 Mar 9.

pubmed_id:21389975

28:

name:Eosinophilic esophagitis

omim_id:610247

[1]:

reference_text:Mordechai, Hien, and David S. Wishart

pubmed_id:

KEGG数据库编号
C00188
DrugBank数据库编号
DB00156
foodb数据库编号
FDB011999
ChemSpider数据库编号
6051
公共化学化合物编号
6288
PDB数据库编号
生物利益的化学实体数据库编号
16857
knapsack数据库编号
C00001394
维基百科编号
Threonine
代谢途径的数据库编号
THR
苯酚资源管理器化合物数据库编号
比格数据库编号
34186
梅林编号
32
虚拟机身份证编号
THR_L
fbonto数据库编号
综合参考
Fujita, Chuzo; Nara, Takashi; Samejima, Hirotoshi; Kinoshita, Shukuo. L-Threonine fermentation. I. Microbial conversion of L-homoserine to L-threonine. Nippon Nogei Kagaku Kaishi (1965), 39(6), 2
一般参考
1:

protein_accession:HMDBP00581

name:Threonine--tRNA ligase, cytoplasmic

uniprot_id:P26639

gene_name:TARS

protein_type:Enzyme

2:

protein_accession:HMDBP00671

name:L-serine dehydratase/L-threonine deaminase

uniprot_id:P20132

gene_name:SDS

protein_type:Enzyme

3:

protein_accession:HMDBP03110

name:Neutral amino acid transporter A

uniprot_id:P43007

gene_name:SLC1A4

protein_type:Unknown

4:

protein_accession:HMDBP03303

name:Threonine synthase-like 1

uniprot_id:Q8IYQ7

gene_name:THNSL1

protein_type:Enzyme

5:

protein_accession:HMDBP05340

name:Monocarboxylate transporter 10

uniprot_id:Q8TF71

gene_name:SLC16A10

protein_type:Transporter

6:

protein_accession:HMDBP07364

name:Acetolactate synthase-like protein

uniprot_id:A1L0T0

gene_name:ILVBL

protein_type:Unknown

7:

protein_accession:HMDBP08972

name:Serine dehydratase-like

uniprot_id:Q96GA7

gene_name:SDSL

protein_type:Enzyme

8:

protein_accession:HMDBP09248

name:Probable threonine--tRNA ligase 2, cytoplasmic

uniprot_id:A2RTX5

gene_name:TARSL2

protein_type:Enzyme

9:

protein_accession:HMDBP09249

name:Threonine--tRNA ligase, mitochondrial

uniprot_id:Q9BW92

gene_name:TARS2

protein_type:Enzyme

蛋白质结合
1:

reference_text:Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762.

pubmed_id:19212411

2:

reference_text:Silwood CJ, Lynch E, Claxson AW, Grootveld MC: 1H and (13)C NMR spectroscopic analysis of human saliva. J Dent Res. 2002 Jun;81(6):422-7.

pubmed_id:12097436

3:

reference_text:Nicholson JK, O'Flynn MP, Sadler PJ, Macleod AF, Juul SM, Sonksen PH: Proton-nuclear-magnetic-resonance studies of serum, plasma and urine from fasting normal and diabetic subjects. Biochem J. 1984 Jan 15;217(2):365-75.

pubmed_id:6696735

4:

reference_text:Wevers RA, Engelke U, Wendel U, de Jong JG, Gabreels FJ, Heerschap A: Standardized method for high-resolution 1H-NMR of cerebrospinal fluid. Clin Chem. 1995 May;41(5):744-51.

pubmed_id:7729054

5:

reference_text:Hagenfeldt L, Bjerkenstedt L, Edman G, Sedvall G, Wiesel FA: Amino acids in plasma and CSF and monoamine metabolites in CSF: interrelationship in healthy subjects. J Neurochem. 1984 Mar;42(3):833-7.

pubmed_id:6198473

6:

reference_text:Peng CT, Wu KH, Lan SJ, Tsai JJ, Tsai FJ, Tsai CH: Amino acid concentrations in cerebrospinal fluid in children with acute lymphoblastic leukemia undergoing chemotherapy. Eur J Cancer. 2005 May;41(8):1158-63. Epub 2005 Apr 14.

pubmed_id:15911239

7:

reference_text:Cynober LA: Plasma amino acid levels with a note on membrane transport: characteristics, regulation, and metabolic significance. Nutrition. 2002 Sep;18(9):761-6.

pubmed_id:12297216

8:

reference_text:Rainesalo S, Keranen T, Palmio J, Peltola J, Oja SS, Saransaari P: Plasma and cerebrospinal fluid amino acids in epileptic patients. Neurochem Res. 2004 Jan;29(1):319-24.

pubmed_id:14992292

9:

reference_text:Vold BS, Keith DE Jr, Slavik M: Urine levels of N-[9-(beta-D-ribofuranosyl)purin-6-ylcarbamoyl]-L-threonine, N6-(delta 2-isopentenyl)adenosine, and 2'-O-methylguanosine as determined by radioimmunoassay for normal subjects and cancer patients. Cancer Res. 1982 Dec;42(12):5265-9.

pubmed_id:7139629

10:

reference_text:Hallgren P, Lundblad A, Svensson S: A new type of carbohydrate-protein linkage in a glycopeptide from normal human urine. J Biol Chem. 1975 Jul 25;250(14):5312-4.

pubmed_id:1141232

11:

reference_text:Wulf G, Finn G, Suizu F, Lu KP: Phosphorylation-specific prolyl isomerization: is there an underlying theme? Nat Cell Biol. 2005 May;7(5):435-41.

pubmed_id:15867923

12:

reference_text:Takeda DY, Parvin JD, Dutta A: Degradation of Cdt1 during S phase is Skp2-independent and is required for efficient progression of mammalian cells through S phase. J Biol Chem. 2005 Jun 17;280(24):23416-23. Epub 2005 Apr 25.

pubmed_id:15855168

13:

reference_text:Nanda N, Bao M, Lin H, Clauser K, Komuves L, Quertermous T, Conley PB, Phillips DR, Hart MJ: Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation. J Biol Chem. 2005 Jul 1;280(26):24680-9. Epub 2005 Apr 25.

pubmed_id:15851471

14:

reference_text:Boneh A, Korman SH, Sato K, Kanno J, Matsubara Y, Lerer I, Ben-Neriah Z, Kure S: A single nucleotide substitution that abolishes the initiator methionine codon of the GLDC gene is prevalent among patients with glycine encephalopathy in Jerusalem. J Hum Genet. 2005;50(5):230-4. Epub 2005 Apr 29.

pubmed_id:15864413

15:

reference_text:Elzinga M, Maron BJ, Adelstein RS: Human heart and platelet actins are products of different genes. Science. 1976 Jan 9;191(4222):94-5.

pubmed_id:1246600

16:

reference_text:Rodriguez-Soriano J, Vallo A, Perez de Nanclares G, Bilbao JR, Castano L: A founder mutation in the CLCNKB gene causes Bartter syndrome type III in Spain. Pediatr Nephrol. 2005 Jul;20(7):891-6. Epub 2005 May 5.

pubmed_id:15875219

17:

reference_text:Boehm G, Cervantes H, Georgi G, Jelinek J, Sawatzki G, Wermuth B, Colombo JP: Effect of increasing dietary threonine intakes on amino acid metabolism of the central nervous system and peripheral tissues in growing rats. Pediatr Res. 1998 Dec;44(6):900-6.

pubmed_id:9853925

18:

reference_text:Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043.

pubmed_id:32033212

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