版本
5.0
创建日期
2005-11-16 15:48:42 UTC
更新日期
2020-10-09 20:58:07 UTC
登录号
HMDB0000164
地位
quantified
二级访问
HMDB0002983

HMDB00164

HMDB0060291

HMDB02983

HMDB60291

名称
Methylamine
描述
Methylamine occurs endogenously from amine catabolism and its tissue levels increase in some pathological conditions, including diabetes. Interestingly, methylamine and ammonia levels are reciprocally controlled by a semicarbazide-sensitive amine oxidase activity that deaminates methylamine to formaldehyde with the production of ammonia and hydrogen peroxide. Methylamine also targets the voltage-operated neuronal potassium channels, probably inducing release of neurotransmitter(s). Semicarbazide-sensitive amine oxidase (SSAO) catalyzes the deamination of primary amines. Such deamination has been shown capable of regulating glucose transport in adipose cells. It has been independently discovered that the primary structure of vascular adhesion protein-1 (VAP-1) is identical to SSAO. Increased serum SSAO activities have been found in patients with diabetic mellitus, vascular disorders, and Alzheimer's disease. The SSAO-catalyzed deamination of endogenous substrates like methylamine led to production of toxic formaldehyde. Chronic elevated methylamine increases the excretion of malondialdehyde and microalbuminuria. Amine oxidase substrates such as methylamine have been shown to stimulate glucose uptake by increasing the recruitment of the glucose transporter GLUT4 from vesicles within the cell to the cell surface. Inhibition of this effect by the presence of semicarbazide and catalase led to the suggestion that the process is mediated by the hydrogen peroxide produced in the oxidation of these amines (PMID: 16049393 , 12686132 , 17406961). Methylamine has been identified as a uremic toxin according to the European Uremic Toxin Working Group (PMID: 22626821).
同义词
1:Aminomethane

2:CH3-NH2

3:MeNH2

4:Methanamine

5:MMA

6:Monomethylamine

7:Anhydrous methylamine

8:Carbinamine

9:Imizin

10:Mercurialin

11:Methyl group

12:Methyl OF gamma-N-methylasparagine

13:Methylamine anhydrous

14:Methylamine aqueous solution

15:Methylamine solution

16:Methylamine solutions

17:Methylaminen

18:Metilamine

19:Metyloamina

20:N-Methylamine

21:NMA

22:NME

23:Methylamine ion (1-)

24:Methylamine nitrate

25:Methylamine perchlorate

26:Methylamine sulfate (1:1)

27:Methylamine sulfate (2:1)

28:Methylamine, 13C-labeled

29:Methylamine, 14C-labeled

30:Methylamine, 15N-labeled

31:Methylamine hydrobromide

32:Methylamine hydrochloride, 14C-labeled

33:Methylamine, cesium salt

34:Methylamine, monopotassium salt

35:Methylammonium

36:Methylammonium ion

37:Methylamine hydroiodide

38:Methylamine, monosodium salt

39:Methylamine bisulfite

40:Methylamine hydride

41:Methylamine hydrochloride

42:Methylamine hydrofluoride

43:Methylamine hydrogen cyanide

44:Monomethylammonium ion

化学式
CH5N
平均分子量
31.0571
等位分子量
31.042199165
化学名称
methanamine
传统名称
methylamine
CAS 登记号
74-89-5
代谢物结构字符串
CN
inchi标识符
InChI=1S/CH5N/c1-2/h2H2,1H3
印记键
BAVYZALUXZFZLV-UHFFFAOYSA-N
分类学
description: belongs to the class of organic compounds known as monoalkylamines. These are organic compounds containing an primary aliphatic amine group.

description:Monoalkylamines

kingdom:Organic compounds

super_class:Organic nitrogen compounds

class:Organonitrogen compounds

sub_class:Amines

molecular_framework:Aliphatic acyclic compounds

1:Hydrocarbon derivatives

2:Organopnictogen compounds

3:Aliphatic acyclic compound

4:Hydrocarbon derivative

5:Organopnictogen compound

6:Primary aliphatic amine

7:a small molecule

8:methylamines

9:one-carbon compound

10:primary aliphatic amine

本体论
term:Physiological effect

definition:The effect on an organism physiology, resulting from its exposure to a chemical.

parent_id:

level:1

type:parent

term:Health effect

definition:A health condition or observation associated with a stimuli or with a biological activity of a chemical.

parent_id:7693

*level:2

type:parent

term:Health condition

definition:A health effect that consists on short or long-term disease, condition, disorder, syndrome or constant abnormality.

parent_id:7694

**level:3

type:parent

term:Kidney disease

definition:A urinary system disease that is located in the kidney. (do).

parent_id:7695

***level:4

type:child

synonym:Renal disease

synonym:Nephropathy

term:Coma

definition:A state of profound unconsciousness associated with markedly depressed cerebral activity. Causes include central nervous system damage, intoxication, and metabolic abnormalities.

parent_id:7695

***level:4

type:child

term:Psychosis

definition:A mental disorder characterized by personality change, impaired functioning, and loss of touch with reality. (NCI)

parent_id:7695

***level:4

type:child

term:Uremia

definition:A disorder characterized by accummulation of solutes in the blood of people with chronic kidney disease. (do).

parent_id:7695

***level:4

type:child

synonym:Uraemia

term:Nervous system disorders

definition:Any disorder (non-neoplastic or neoplastic) that affects the brain, spinal cord, or peripheral nerves.

parent_id:7695

***level:4

type:parent

term:Renal and urinary disorders

definition:Any disorder that affects the kidneys and the urologic system.

parent_id:7695

***level:4

type:parent

term:Psychiatric disorders

definition:A group of disorders characterized by behavioral and/or psychological abnormalities, often accompanied by physical symptoms. the symptoms may cause clinically significant distress or impairment in social and occupational areas of functioning. representative examples include anxiety disorders, cognitive disorders, mood disorders and schizophrenia. (nci).

parent_id:7695

***level:4

type:parent

term:Gastrointestinal disorders

definition:Any disorder (non-neoplastic or neoplastic) that affects the gastrointestinal tract.

parent_id:7695

***level:4

type:parent

term:Cardiac disorders

definition:Any disorder that affects the heart.

parent_id:7695

***level:4

type:parent

term:Observation

definition:A short term health effect which reflects the reponse of the body to stimuli or is a symptom of a disease or condition; also includes health status which reflects stage in life.

parent_id:7694

**level:3

type:parent

term:Bleeding

definition:

parent_id:7717

***level:4

type:child

term:Investigations

definition:The act or process of a systematic and thorough examination; research, study; the process of inquiring into or following up, intended to develop facts. (nci).

parent_id:7717

***level:4

type:parent

term:Disposition

definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.

parent_id:

level:1

type:parent

term:Route of exposure

definition:A mean by which a chemical agent comes in contact with an organism, either under intended or unintended circumstances.

parent_id:7724

*level:2

type:parent

term:Parenteral

definition:Chemical exposure via the a route other than the alimentary canal.

parent_id:7743

**level:3

type:parent

term:Dermal

definition:Chemical exposure by contact with the dermis or a cuticle or cornified region of the epidermis.

parent_id:7745

***level:4

type:child

synonym:Topical

synonym:Skin contact

synonym:Cutaneous (related but nor necessarily exact synonym)

synonym:Transdermal

term:Enteral

definition:Chemical exposure via the alimentary canal (mouth to anus).

parent_id:7743

**level:3

type:parent

term:Ingestion

definition:Chemical exposure facilitated by entry through the mouth.

parent_id:7744

***level:4

type:child

synonym:Digestion

term:Source

definition:Natural or synthetic origin of a chemical.

parent_id:7724

*level:2

type:parent

term:Endogenous

definition:

parent_id:7735

**level:3

type:child

term:Food

definition:

parent_id:7735

**level:3

type:child

term:Biological

definition:A living organism (species or a higher taxonomy rank), in which a chemical can be found.

parent_id:7735

**level:3

type:parent

term:Plant

definition:A living organism belonging to the kingdom plantea. typically, it grows in a permanent site, absorbs water and inorganic substances through its roots, and synthesizes nutrients in its leaves by photosynthesis using the green pigment chlorophyll. examples incude trees, shrubs, herbs, grasses, ferns, and mosses.

parent_id:7736

***level:4

type:parent

synonym:Flora

term:Biological location

definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.

parent_id:7724

*level:2

type:parent

term:Biofluid and excreta

definition:A liquid, semi-solid or solid material originating in the body.

parent_id:7725

**level:3

type:parent

term:Saliva

definition:The watery fluid in the mouth made by the salivary glands. saliva moistens food to help digestion and it helps protect the mouth against infections. (nci).

parent_id:7731

***level:4

type:child

term:Feces

definition:The material discharged from the bowel during defecation. It consists of undigested food, intestinal mucus, epithelial cells, and bacteria.

parent_id:7731

***level:4

type:child

synonym:Fecal

synonym:Stool

synonym:Faecal

synonym:Faeces

term:Urine

definition:Excretion in liquid state processed by the kidney.

parent_id:7731

***level:4

type:child

term:Blood

definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.

parent_id:7731

***level:4

type:child

term:Sweat

definition:Secretion produced by a sweat gland.

parent_id:7731

***level:4

type:child

term:Subcellular

definition:An anatomical organizational level including a component within a biological cell .

parent_id:7725

**level:3

type:parent

term:Cytoplasm

definition:The portion of the cell contained within the plasma membrane but excluding the nucleus.

parent_id:7730

***level:4

type:child

synonym:Cytoplasma

term:Process

definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.

parent_id:

level:1

type:parent

term:Naturally occurring process

definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.

parent_id:7659

*level:2

type:parent

term:Biological process

definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.

parent_id:7660

**level:3

type:parent

term:Biochemical pathway

definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.

parent_id:7661

***level:4

type:parent

term:Role

definition:The purpose or function assumed by a chemical, either naturally or as intended by humans .

parent_id:

level:1

type:parent

term:Industrial application

definition:The assumed function of a chemical utilized by human.

parent_id:7671

*level:2

type:parent

term:Pharmaceutical industry

definition:A pharmacologic activity for which a chemical substance is utilized owing to its biological role.

parent_id:7678

**level:3

type:parent

term:Pharmaceutical

definition:

parent_id:7679

***level:4

type:child

term:Environmental role

definition:A direct or indirect function of chemical product or process which affect the components of the environment.

parent_id:7671

*level:2

type:parent

term:Air pollutant

definition:An airborne chemical substance, natural or synthetic, that is harmful to organisms and the environment. may consist of solid particles, liquid droplets or gases, or combinations of these forms.

parent_id:7692

**level:3

type:child

状态
Liquid
实验性质
1:

kind:water_solubility

value:1080 mg/mL at 25 °C

source:

2:

kind:logp

value:-0.57

source:HANSCH,C ET AL. (1995)

3:

kind:melting_point

value:-93.4 °C

source:

预测性质
1:

kind:logp

value:-1.06

source:ALOGPS

2:

kind:logs

value:1.07

source:ALOGPS

3:

kind:solubility

value:367 g/L

source:ALOGPS

4:

kind:logp

value:-0.63

source:ChemAxon

5:

kind:pka_strongest_basic

value:10.08

source:ChemAxon

6:

kind:iupac

value:methanamine

source:ChemAxon

7:

kind:average_mass

value:31.0571

source:ChemAxon

8:

kind:mono_mass

value:31.042199165

source:ChemAxon

9:

kind:smiles

value:CN

source:ChemAxon

10:

kind:formula

value:CH5N

source:ChemAxon

11:

kind:inchi

value:InChI=1S/CH5N/c1-2/h2H2,1H3

source:ChemAxon

12:

kind:inchikey

value:BAVYZALUXZFZLV-UHFFFAOYSA-N

source:ChemAxon

13:

kind:polar_surface_area

value:26.02

source:ChemAxon

14:

kind:refractivity

value:9.92

source:ChemAxon

15:

kind:polarizability

value:3.86

source:ChemAxon

16:

kind:rotatable_bond_count

value:0

source:ChemAxon

17:

kind:acceptor_count

value:1

source:ChemAxon

18:

kind:donor_count

value:1

source:ChemAxon

19:

kind:physiological_charge

value:1

source:ChemAxon

20:

kind:formal_charge

value:0

source:ChemAxon

21:

kind:number_of_rings

value:0

source:ChemAxon

22:

kind:bioavailability

value:Yes

source:ChemAxon

23:

kind:rule_of_five

value:Yes

source:ChemAxon

24:

kind:ghose_filter

value:No

source:ChemAxon

25:

kind:veber_rule

value:Yes

source:ChemAxon

26:

kind:mddr_like_rule

value:No

source:ChemAxon

光谱
生物学性质
1:

cellular:(1):Cytoplasm

2:

biospecimen:(1):Blood

biospecimen:(2):Feces

biospecimen:(3):Saliva

biospecimen:(4):Sweat

biospecimen:(5):Urine

3:

4:

[1]:

name:Alkaptonuria

smpdb_id:SMP00169

kegg_map_id:

[2]:

name:Citalopram Action Pathway

smpdb_id:SMP00424

kegg_map_id:

[3]:

name:Citalopram Metabolism Pathway

smpdb_id:SMP00627

kegg_map_id:

[4]:

name:Disulfiram Action Pathway

smpdb_id:SMP00429

kegg_map_id:

[5]:

name:Dopamine beta-hydroxylase deficiency

smpdb_id:SMP00498

kegg_map_id:

[6]:

name:Hawkinsinuria

smpdb_id:SMP00190

kegg_map_id:

[7]:

name:Monoamine oxidase-a deficiency (MAO-A)

smpdb_id:SMP00533

kegg_map_id:

[8]:

name:Tyrosine metabolism

smpdb_id:

kegg_map_id:map00350

[9]:

name:Tyrosinemia Type I

smpdb_id:SMP00218

kegg_map_id:

[10]:

name:Tyrosinemia, transient, of the newborn

smpdb_id:SMP00494

kegg_map_id:

正常浓度
1:

biospecimen:Blood

concentration_value:1.0 (0.37-4.0)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

2:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

3:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Not Specified

subject_sex:Both

subject_condition:Normal

4:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

5:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

6:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

7:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

8:

biospecimen:Feces

concentration_value:258

concentration_units:nmol/g wet feces

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

9:

biospecimen:Feces

concentration_value:196

concentration_units:nmol/g wet feces

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

10:

biospecimen:Feces

concentration_value:178

concentration_units:nmol/g wet feces

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

11:

biospecimen:Saliva

concentration_value:25.55 +/- 13.26

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

12:

biospecimen:Saliva

concentration_value:158 (0.00-316)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

13:

biospecimen:Sweat

concentration_value:< 10

concentration_units:uM

subject_age:Adult (60 years old)

subject_sex:Male

subject_condition:Normal

14:

biospecimen:Sweat

concentration_value:< 10

concentration_units:uM

subject_age:Adult (40 years old)

subject_sex:Male

subject_condition:Normal

15:

biospecimen:Urine

concentration_value:5.906 +/- 3.776

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

16:

biospecimen:Urine

concentration_value:1.46 +/- 0.13

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

17:

biospecimen:Urine

concentration_value:13.6 +/- 3.1

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

18:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

19:

biospecimen:Urine

concentration_value:4.0 (1.5-11.9)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

20:

biospecimen:Urine

concentration_value:10.5 (9.8-12.5)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

异常浓度
1:

biospecimen:Blood

concentration_value:18.68 +/- 3.22

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:uremia

2:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Crohn disease

3:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Ulcerative colitis

4:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Not Specified

patient_information:asymptomatic diverticulosis

5:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Not Specified

patient_information:symptomatic uncomplicated diverticular disease

6:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Crohn's disease

7:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Ulcerative colitis

8:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Crohn’s Disease

9:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Ulcerative Colitis

10:

biospecimen:Urine

concentration_value:8.09 +/- 6.297

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Eosinophilic esophagitis

疾病参考
1:

name:Crohn's disease

omim_id:266600

[1]:

reference_text:Lapidus A, Akerlund JE, Einarsson C: Gallbladder bile composition in patients with Crohn 's disease. World J Gastroenterol. 2006 Jan 7;12(1):70-4.

pubmed_id:16440420

[2]:

reference_text:Ehrenpreis ED, Salvino M, Craig RM: Improving the serum D-xylose test for the identification of patients with small intestinal malabsorption. J Clin Gastroenterol. 2001 Jul;33(1):36-40.

pubmed_id:11418788

[3]:

reference_text:Brydon WG, Nyhlin H, Eastwood MA, Merrick MV: Serum 7 alpha-hydroxy-4-cholesten-3-one and selenohomocholyltaurine (SeHCAT) whole body retention in the assessment of bile acid induced diarrhoea. Eur J Gastroenterol Hepatol. 1996 Feb;8(2):117-23.

pubmed_id:8723414

[4]:

reference_text:Williams HR, Cox IJ, Walker DG, North BV, Patel VM, Marshall SE, Jewell DP, Ghosh S, Thomas HJ, Teare JP, Jakobovits S, Zeki S, Welsh KI, Taylor-Robinson SD, Orchard TR: Characterization of inflammatory bowel disease with urinary metabolic profiling. Am J Gastroenterol. 2009 Jun;104(6):1435-44. doi: 10.1038/ajg.2009.175. Epub 2009 Apr 28.

pubmed_id:19491857

[5]:

reference_text:Marchesi JR, Holmes E, Khan F, Kochhar S, Scanlan P, Shanahan F, Wilson ID, Wang Y: Rapid and noninvasive metabonomic characterization of inflammatory bowel disease. J Proteome Res. 2007 Feb;6(2):546-51.

pubmed_id:17269711

[6]:

reference_text:Ahmed I, Greenwood R, Costello Bde L, Ratcliffe NM, Probert CS: An investigation of fecal volatile organic metabolites in irritable bowel syndrome. PLoS One. 2013;8(3):e58204. doi: 10.1371/journal.pone.0058204. Epub 2013 Mar 13.

pubmed_id:23516449

[7]:

reference_text:Walton C, Fowler DP, Turner C, Jia W, Whitehead RN, Griffiths L, Dawson C, Waring RH, Ramsden DB, Cole JA, Cauchi M, Bessant C, Hunter JO: Analysis of volatile organic compounds of bacterial origin in chronic gastrointestinal diseases. Inflamm Bowel Dis. 2013 Sep;19(10):2069-78. doi: 10.1097/MIB.0b013e31829a91f6.

pubmed_id:23867873

[8]:

reference_text:De Preter V, Machiels K, Joossens M, Arijs I, Matthys C, Vermeire S, Rutgeerts P, Verbeke K: Faecal metabolite profiling identifies medium-chain fatty acids as discriminating compounds in IBD. Gut. 2015 Mar;64(3):447-58. doi: 10.1136/gutjnl-2013-306423. Epub 2014 May 8.

pubmed_id:24811995

[9]:

reference_text:Bjerrum JT, Wang Y, Hao F, Coskun M, Ludwig C, Gunther U, Nielsen OH: Metabonomics of human fecal extracts characterize ulcerative colitis, Crohn's disease and healthy individuals. Metabolomics. 2015;11:122-133. Epub 2014 Jun 1.

pubmed_id:25598765

[10]:

reference_text:Ahmed I, Greenwood R, Costello B, Ratcliffe N, Probert CS: Investigation of faecal volatile organic metabolites as novel diagnostic biomarkers in inflammatory bowel disease. Aliment Pharmacol Ther. 2016 Mar;43(5):596-611. doi: 10.1111/apt.13522. Epub 2016 Jan 25.

pubmed_id:26806034

[11]:

reference_text:Lee T, Clavel T, Smirnov K, Schmidt A, Lagkouvardos I, Walker A, Lucio M, Michalke B, Schmitt-Kopplin P, Fedorak R, Haller D: Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD. Gut. 2017 May;66(5):863-871. doi: 10.1136/gutjnl-2015-309940. Epub 2016 Feb 4.

pubmed_id:26848182

[12]:

reference_text:Kolho KL, Pessia A, Jaakkola T, de Vos WM, Velagapudi V: Faecal and Serum Metabolomics in Paediatric Inflammatory Bowel Disease. J Crohns Colitis. 2017 Mar 1;11(3):321-334. doi: 10.1093/ecco-jcc/jjw158.

pubmed_id:27609529

[13]:

reference_text:Azario I, Pievani A, Del Priore F, Antolini L, Santi L, Corsi A, Cardinale L, Sawamoto K, Kubaski F, Gentner B, Bernardo ME, Valsecchi MG, Riminucci M, Tomatsu S, Aiuti A, Biondi A, Serafini M: Neonatal umbilical cord blood transplantation halts skeletal disease progression in the murine model of MPS-I. Sci Rep. 2017 Aug 25;7(1):9473. doi: 10.1038/s41598-017-09958-9.

pubmed_id:28842642

2:

name:Uremia

omim_id:

[1]:

reference_text:Shoemaker JD, Elliott WH: Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease. J Chromatogr. 1991 Jan 2;562(1-2):125-38.

pubmed_id:2026685

[2]:

reference_text:Guneral F, Bachmann C: Age-related reference values for urinary organic acids in a healthy Turkish pediatric population. Clin Chem. 1994 Jun;40(6):862-6.

pubmed_id:8087979

[3]:

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pubmed_id:

[17]:

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pubmed_id:

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pubmed_id:

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pubmed_id:

[20]:

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pubmed_id:

[21]:

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pubmed_id:

3:

name:Diverticular disease

omim_id:

[1]:

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pubmed_id:27622378

4:

name:Eosinophilic esophagitis

omim_id:610247

[1]:

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pubmed_id:

5:

name:Ulcerative colitis

omim_id:

[1]:

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[13]:

reference_text:Azario I, Pievani A, Del Priore F, Antolini L, Santi L, Corsi A, Cardinale L, Sawamoto K, Kubaski F, Gentner B, Bernardo ME, Valsecchi MG, Riminucci M, Tomatsu S, Aiuti A, Biondi A, Serafini M: Neonatal umbilical cord blood transplantation halts skeletal disease progression in the murine model of MPS-I. Sci Rep. 2017 Aug 25;7(1):9473. doi: 10.1038/s41598-017-09958-9.

pubmed_id:28842642

KEGG数据库编号
C00218
DrugBank数据库编号
DB01828
foodb数据库编号
FDB003958
ChemSpider数据库编号
6089
公共化学化合物编号
6329
PDB数据库编号
生物利益的化学实体数据库编号
16830
knapsack数据库编号
维基百科编号
Methylamine
代谢途径的数据库编号
METHYLAMINE
苯酚资源管理器化合物数据库编号
比格数据库编号
1800349
梅林编号
3767
虚拟机身份证编号
MMA
fbonto数据库编号
综合参考
Denham, William S.; Knapp, Lionel F. The preparation of methylamine from ammonium methyl sulfate. Journal of the Chemical Society, Transactions (1920), 117 236-47.
一般参考
1:

protein_accession:HMDBP00161

name:Amine oxidase [flavin-containing] B

uniprot_id:P27338

gene_name:MAOB

protein_type:Unknown

2:

protein_accession:HMDBP00169

name:Amine oxidase [flavin-containing] A

uniprot_id:P21397

gene_name:MAOA

protein_type:Unknown

3:

protein_accession:HMDBP00393

name:Membrane primary amine oxidase

uniprot_id:Q16853

gene_name:AOC3

protein_type:Unknown

4:

protein_accession:HMDBP00394

name:Retina-specific copper amine oxidase

uniprot_id:O75106

gene_name:AOC2

protein_type:Unknown

5:

protein_accession:HMDBP00795

name:Glycine dehydrogenase [decarboxylating], mitochondrial

uniprot_id:P23378

gene_name:GLDC

protein_type:Enzyme

蛋白质结合
1:

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pubmed_id:7762816

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pubmed_id:12097436

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pubmed_id:14500886

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pubmed_id:12787933

5:

reference_text:Stanic P, Tandara M, Sonicki Z, Simunic V, Radakovic B, Suchanek E: Comparison of protective media and freezing techniques for cryopreservation of human semen. Eur J Obstet Gynecol Reprod Biol. 2000 Jul;91(1):65-70.

pubmed_id:10817881

6:

reference_text:Zeisel SH, Gettner S, Youssef M: Formation of aliphatic amine precursors of N-nitrosodimethylamine after oral administration of choline and choline analogues in the rat. Food Chem Toxicol. 1989 Jan;27(1):31-4.

pubmed_id:2703191

7:

reference_text:O'Sullivan J, Unzeta M, Healy J, O'Sullivan MI, Davey G, Tipton KF: Semicarbazide-sensitive amine oxidases: enzymes with quite a lot to do. Neurotoxicology. 2004 Jan;25(1-2):303-15.

pubmed_id:14697905

8:

reference_text:Sawetawan C, Bruns ES, Prins GS: Improvement of post-thaw sperm motility in poor quality human semen. Fertil Steril. 1993 Oct;60(4):706-10.

pubmed_id:8405530

9:

reference_text:Gunnarsson M, Sundstrom P, Stigbrand T, Jensen PE: Native and transformed alpha2-macroglobulin in plasma from patients with multiple sclerosis. Acta Neurol Scand. 2003 Jul;108(1):16-21.

pubmed_id:12807388

10:

reference_text:Kokubo T, Kushitani H, Sakka S, Kitsugi T, Yamamuro T: Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramic A-W. J Biomed Mater Res. 1990 Jun;24(6):721-34.

pubmed_id:2361964

11:

reference_text:Mashige F, Imai K, Osuga T: A simple and sensitive assay of total serum bile acids. Clin Chim Acta. 1976 Jul 1;70(1):79-86.

pubmed_id:947625

12:

reference_text:Wosikowski K, Biedermann E, Rattel B, Breiter N, Jank P, Loser R, Jansen G, Peters GJ: In vitro and in vivo antitumor activity of methotrexate conjugated to human serum albumin in human cancer cells. Clin Cancer Res. 2003 May;9(5):1917-26.

pubmed_id:12738750

13:

reference_text:Tencer J, Thysell H, Andersson K, Grubb A: Long-term stability of albumin, protein HC, immunoglobulin G, kappa- and lambda-chain-immunoreactivity, orosomucoid and alpha 1-antitrypsin in urine stored at -20 degrees C. Scand J Urol Nephrol. 1997 Feb;31(1):67-71.

pubmed_id:9060087

14:

reference_text:Thiele I, Swainston N, Fleming RM, Hoppe A, Sahoo S, Aurich MK, Haraldsdottir H, Mo ML, Rolfsson O, Stobbe MD, Thorleifsson SG, Agren R, Bolling C, Bordel S, Chavali AK, Dobson P, Dunn WB, Endler L, Hala D, Hucka M, Hull D, Jameson D, Jamshidi N, Jonsson JJ, Juty N, Keating S, Nookaew I, Le Novere N, Malys N, Mazein A, Papin JA, Price ND, Selkov E Sr, Sigurdsson MI, Simeonidis E, Sonnenschein N, Smallbone K, Sorokin A, van Beek JH, Weichart D, Goryanin I, Nielsen J, Westerhoff HV, Kell DB, Mendes P, Palsson BO: A community-driven global reconstruction of human metabolism. Nat Biotechnol. 2013 May;31(5):419-25. doi: 10.1038/nbt.2488. Epub 2013 Mar 3.

pubmed_id:23455439

15:

reference_text:Pirisino R, Ghelardini C, De Siena G, Malmberg P, Galeotti N, Cioni L, Banchelli G, Raimondi L: Methylamine: a new endogenous modulator of neuron firing? Med Sci Monit. 2005 Aug;11(8):RA257-61. Epub 2005 Jul 25.

pubmed_id:16049393

16:

reference_text:Yu PH, Wright S, Fan EH, Lun ZR, Gubisne-Harberle D: Physiological and pathological implications of semicarbazide-sensitive amine oxidase. Biochim Biophys Acta. 2003 Apr 11;1647(1-2):193-9.

pubmed_id:12686132

17:

reference_text:McDonald A, Tipton K, O'Sullivan J, Olivieri A, Davey G, Coonan AM, Fu W: Modelling the roles of MAO and SSAO in glucose transport. J Neural Transm (Vienna). 2007;114(6):783-6. Epub 2007 Apr 5.

pubmed_id:17406961

18:

reference_text:Duranton F, Cohen G, De Smet R, Rodriguez M, Jankowski J, Vanholder R, Argiles A: Normal and pathologic concentrations of uremic toxins. J Am Soc Nephrol. 2012 Jul;23(7):1258-70. doi: 10.1681/ASN.2011121175. Epub 2012 May 24.

pubmed_id:22626821

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