版本
5.0
创建日期
2005-11-16 15:48:42 UTC
更新日期
2021-09-14 15:45:28 UTC
登录号
HMDB0000162
地位
quantified
二级访问
HMDB00162

名称
L-Proline
描述
Proline (Pro), also known as L-proline is an alpha-amino acid. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). Amino acids are organic compounds that contain amino (–NH2) and carboxyl (–COOH) functional groups, along with a side chain (R group) specific to each amino acid. Proline is one of 20 proteinogenic amino acids, i.e., the amino acids used in the biosynthesis of proteins. Proline is found in all organisms ranging from bacteria to plants to animals. It is classified as an aliphatic, non-polar amino acid. Proline is sometimes called an imino acid, although the IUPAC definition of an imine requires a carbon-nitrogen double bond. Proline is a non-essential amino acid that is synthesized from glutamic acid. It is an essential component of collagen and is important for proper functioning of joints and tendons. Proline is derived from the amino acid L-glutamate in which glutamate-5-semialdehyde is first formed by glutamate 5-kinase and glutamate-5-semialdehyde dehydrogenase (which requires NADH or NADPH). This semialdehyde can then either spontaneously cyclize to form 1-pyrroline-5-carboxylic acid, which is reduced to proline by pyrroline-5-carboxylate reductase, or turned into ornithine by ornithine aminotransferase, followed by cyclization by ornithine cyclodeaminase to form proline. L-Proline has been found to act as a weak agonist of the glycine receptor and of both NMDA and non-NMDA ionotropic glutamate receptors. It has been proposed to be a potential endogenous excitotoxin/neurotoxin. Studies in rats have shown that when injected into the brain, proline non-selectively destroys pyramidal and granule cells (PMID: 3409032 ). Therefore, under certain conditions proline can act as a neurotoxin and a metabotoxin. A neurotoxin causes damage to nerve cells and nerve tissues. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels. Chronically high levels of proline are associated with at least five inborn errors of metabolism, including hyperprolinemia type I, hyperprolinemia type II, iminoglycinuria, prolinemia type II, and pyruvate carboxylase deficiency. People with hyperprolinemia type I often do not show any symptoms even though they have proline levels in their blood between 3 and 10 times the normal level. Some individuals with hyperprolinemia type I exhibit seizures, intellectual disability, or other neurological or psychiatric problems. Hyperprolinemia type II results in proline levels in the blood between 10 and 15 times higher than normal, and high levels of a related compound called pyrroline-5-carboxylate. Hyperprolinemia type II has signs and symptoms that vary in severity and is more likely than type I to involve seizures or intellectual disability.
同义词
1:(-)-(S)-Proline

2:(-)-2-Pyrrolidinecarboxylic acid

3:(-)-Proline

4:(2S)-Pyrrolidine-2-carboxylic acid

5:(S)-2-Carboxypyrrolidine

6:(S)-2-Pyrrolidinecarboxylic acid

7:(S)-Pyrrolidine-2-carboxylic acid

8:2-Pyrrolidinecarboxylic acid

9:L-(-)-Proline

10:L-alpha-Pyrrolidinecarboxylic acid

11:L-Prolin

12:L-Pyrrolidine-2-carboxylic acid

13:P

14:Prolina

15:PROLINE

16:Prolinum

17:(-)-2-Pyrrolidinecarboxylate

18:(2S)-Pyrrolidine-2-carboxylate

19:(S)-2-Pyrrolidinecarboxylate

20:(S)-Pyrrolidine-2-carboxylate

21:2-Pyrrolidinecarboxylate

22:L-a-Pyrrolidinecarboxylate

23:L-a-Pyrrolidinecarboxylic acid

24:L-alpha-Pyrrolidinecarboxylate

25:L-Α-pyrrolidinecarboxylate

26:L-Α-pyrrolidinecarboxylic acid

27:L-Pyrrolidine-2-carboxylate

28:(S)-(-)-Proline

29:(S)-(-)-Pyrrolidine-2-carboxylate

30:(S)-(-)-Pyrrolidine-2-carboxylic acid

31:(S)-2-Pyrralidinecarboxylate

32:(S)-2-Pyrralidinecarboxylic acid

33:(S)-Proline

34:L Proline

化学式
C5H9NO2
平均分子量
115.1305
等位分子量
115.063328537
化学名称
(2S)-pyrrolidine-2-carboxylic acid
传统名称
L-proline
CAS 登记号
147-85-3
代谢物结构字符串
OC(=O)[C@@H]1CCCN1
inchi标识符
InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1
印记键
ONIBWKKTOPOVIA-BYPYZUCNSA-N
分类学
description: belongs to the class of organic compounds known as proline and derivatives. Proline and derivatives are compounds containing proline or a derivative thereof resulting from reaction of proline at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.

description:Proline and derivatives

kingdom:Organic compounds

super_class:Organic acids and derivatives

class:Carboxylic acids and derivatives

sub_class:Amino acids, peptides, and analogues

molecular_framework:Aliphatic heteromonocyclic compounds

1:Amino acids

2:Azacyclic compounds

3:Carbonyl compounds

4:Carboxylic acids

5:Dialkylamines

6:Hydrocarbon derivatives

7:L-alpha-amino acids

8:Monocarboxylic acids and derivatives

9:Organic oxides

10:Organopnictogen compounds

11:Pyrrolidine carboxylic acids

12:Aliphatic heteromonocyclic compound

13:Alpha-amino acid

14:Amine

15:Amino acid

16:Azacycle

17:Carbonyl group

18:Carboxylic acid

19:Hydrocarbon derivative

20:L-alpha-amino acid

21:Monocarboxylic acid or derivatives

22:Organic nitrogen compound

23:Organic oxide

24:Organic oxygen compound

25:Organoheterocyclic compound

26:Organonitrogen compound

27:Organooxygen compound

28:Organopnictogen compound

29:Proline or derivatives

30:Pyrrolidine

31:Pyrrolidine carboxylic acid

32:Pyrrolidine carboxylic acid or derivatives

33:Secondary aliphatic amine

34:Secondary amine

35:Common amino acids

36:L-alpha-amino acid

37:glutamine family amino acid

38:proline

39:proteinogenic amino acid

本体论
term:Physiological effect

definition:The effect on an organism physiology, resulting from its exposure to a chemical.

parent_id:

level:1

type:parent

term:Health effect

definition:A health condition or observation associated with a stimuli or with a biological activity of a chemical.

parent_id:7693

*level:2

type:parent

term:Observation

definition:A short term health effect which reflects the reponse of the body to stimuli or is a symptom of a disease or condition; also includes health status which reflects stage in life.

parent_id:7694

**level:3

type:parent

term:Attachment loss

definition:

parent_id:7717

***level:4

type:child

term:Missing teeth

definition:

parent_id:7717

***level:4

type:child

term:Periodontal Probing Depth

definition:

parent_id:7717

***level:4

type:child

term:Tooth Decay

definition:

parent_id:7717

***level:4

type:child

term:Health condition

definition:A health effect that consists on short or long-term disease, condition, disorder, syndrome or constant abnormality.

parent_id:7694

**level:3

type:parent

term:Hemodialysis

definition:

parent_id:7695

***level:4

type:child

synonym:Haemodialysis

term:Disposition

definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.

parent_id:

level:1

type:parent

term:Route of exposure

definition:A mean by which a chemical agent comes in contact with an organism, either under intended or unintended circumstances.

parent_id:7724

*level:2

type:parent

term:Enteral

definition:Chemical exposure via the alimentary canal (mouth to anus).

parent_id:7743

**level:3

type:parent

term:Ingestion

definition:Chemical exposure facilitated by entry through the mouth.

parent_id:7744

***level:4

type:child

synonym:Digestion

term:Source

definition:Natural or synthetic origin of a chemical.

parent_id:7724

*level:2

type:parent

term:Endogenous

definition:

parent_id:7735

**level:3

type:child

term:Food

definition:

parent_id:7735

**level:3

type:child

term:Synthetic

definition:A man-made product or sample in which a chemical can be found.

parent_id:7735

**level:3

type:child

term:Biological

definition:A living organism (species or a higher taxonomy rank), in which a chemical can be found.

parent_id:7735

**level:3

type:parent

term:Animal

definition:A living organism belonging to the kingdom animalia. it feeds on organic matter, typically having specialized sense organs and nervous system and able to respond rapidly to stimuli.

parent_id:7736

***level:4

type:child

synonym:Fauna

term:Plant

definition:A living organism belonging to the kingdom plantea. typically, it grows in a permanent site, absorbs water and inorganic substances through its roots, and synthesizes nutrients in its leaves by photosynthesis using the green pigment chlorophyll. examples incude trees, shrubs, herbs, grasses, ferns, and mosses.

parent_id:7736

***level:4

type:parent

synonym:Flora

term:Biological location

definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.

parent_id:7724

*level:2

type:parent

term:Tissue and substructures

definition:An anatomical organizational level including multiple cells yet not comprising a complete organ .

parent_id:7725

**level:3

type:parent

term:All tissues

definition:All tissues in the body of the organism.

parent_id:7729

***level:4

type:child

term:Placenta

definition:An organ present in some vertebrates during embryonic gestation that surrounds the fetus and provides it with nutrients and oxygen, facilitates gas and waste exchange between the fetus and mother, and provides parasitic cloaking from the mother's immune system by excretion of neurokinin b. (nci).

parent_id:7729

***level:4

type:child

term:Organ and components

definition:An anatomical organizational level including multiple tissues or substructures, which enables a common biological function.

parent_id:7725

**level:3

type:parent

term:Prostate

definition:The male reproductive accessory gland that produces prostatic fluid and is located adjacent to or around the urethra distal to the urinary bladder in mammals. (nci).

parent_id:7727

***level:4

type:child

synonym:Prostate gland

term:Biofluid and excreta

definition:A liquid, semi-solid or solid material originating in the body.

parent_id:7725

**level:3

type:parent

term:Urine

definition:Excretion in liquid state processed by the kidney.

parent_id:7731

***level:4

type:child

term:Saliva

definition:The watery fluid in the mouth made by the salivary glands. saliva moistens food to help digestion and it helps protect the mouth against infections. (nci).

parent_id:7731

***level:4

type:child

term:Feces

definition:The material discharged from the bowel during defecation. It consists of undigested food, intestinal mucus, epithelial cells, and bacteria.

parent_id:7731

***level:4

type:child

synonym:Fecal

synonym:Stool

synonym:Faecal

synonym:Faeces

term:Blood

definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.

parent_id:7731

***level:4

type:child

term:Breast milk

definition:Portion of secreted substance produced by the mammary gland.

parent_id:7731

***level:4

type:child

term:Sweat

definition:Secretion produced by a sweat gland.

parent_id:7731

***level:4

type:child

term:Cerebrospinal fluid

definition:The fluid that is contained within the brain ventricles, the subarachnoid space and the central canal of the spinal cord. (nci).

parent_id:7731

***level:4

type:child

synonym:Csf

term:Subcellular

definition:An anatomical organizational level including a component within a biological cell .

parent_id:7725

**level:3

type:parent

term:Cytoplasm

definition:The portion of the cell contained within the plasma membrane but excluding the nucleus.

parent_id:7730

***level:4

type:child

synonym:Cytoplasma

term:Mitochondria

definition:

parent_id:7730

***level:4

type:child

term:Lysosome

definition:В A sac-like compartment inside a cell that has enzymes that can break down cellular components that need to be destroyed. (NCI).

parent_id:7730

***level:4

type:child

term:Endoplasmic reticulum

definition:A network of tubular membranes within the cytoplasm of the cell, occurring either with a smooth surface (smooth endoplasmic reticulum) or studded with ribosomes (rough endoplasmic reticulum), involved in the transport of materials. (Infoplease Dictionary via NCI)

parent_id:7730

***level:4

type:child

synonym:Er

term:Cell and elements

definition:An anatomical organizational level comprising of a single cell (or a fragment in some exceptions). a cell is defined by its type or function. it is the smallest unit of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid.

parent_id:7725

**level:3

type:parent

term:Extracellular

definition:The space external to the outermost structure of a cell.

parent_id:7732

***level:4

type:child

synonym:Extracellular region

term:Process

definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.

parent_id:

level:1

type:parent

term:Naturally occurring process

definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.

parent_id:7659

*level:2

type:parent

term:Biological process

definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.

parent_id:7660

**level:3

type:parent

term:Biochemical pathway

definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.

parent_id:7661

***level:4

type:parent

term:Role

definition:The purpose or function assumed by a chemical, either naturally or as intended by humans .

parent_id:

level:1

type:parent

term:Indirect biological role

definition:An indirect function of a chemical which affect the physiological state of any organism (apart from the source organism, if of biological source).

parent_id:7671

*level:2

type:parent

term:Neurotoxin

definition:A chemical substance that interferes with the normal functioning of the nervous system.

parent_id:7691

**level:3

type:child

synonym:Neurotoxic

synonym:Neurotoxic agent

term:Metabotoxin

definition:An endogenous metabolite that causes adverse health effects at chronically high levels.

parent_id:7691

**level:3

type:child

term:Environmental role

definition:A direct or indirect function of chemical product or process which affect the components of the environment.

parent_id:7671

*level:2

type:parent

term:Environmental contaminant

definition:A chemical substance, natural or synthetic, that when present in sufficient concentrations is harmful to organisms and the environment.

parent_id:7692

**level:3

type:child

synonym:Pollutant

synonym:Contaminant

term:Industrial application

definition:The assumed function of a chemical utilized by human.

parent_id:7671

*level:2

type:parent

term:Food and nutrition

definition:A chemical purpose related to manufacturing of food and nutrition products.

parent_id:7678

**level:3

type:parent

term:Nutritional supplement

definition:

parent_id:7687

***level:4

type:child

synonym:Nutraceutical

synonym:Dietary supplement

term:Pharmaceutical industry

definition:A pharmacologic activity for which a chemical substance is utilized owing to its biological role.

parent_id:7678

**level:3

type:parent

term:Pharmaceutical

definition:

parent_id:7679

***level:4

type:child

term:Biological role

definition:The biological function of a chemical. the biological role answers the question how a chemical is involved in molecular processes in an organism. this can include biochemical effects of non-endogenous chemicals, which are also assigned an industrial application such as pharmaceuticals. the biological role is limited to cellular levls, and will not include role at system process level, such as a chemical which has a role in a disease.

parent_id:7671

*level:2

type:parent

term:Drug metabolite

definition:

parent_id:7672

**level:3

type:child

term:Waste product

definition:A chemical that is generated in a metabolic process and is destined to be excreted from the body. It commonly consists of water, nitrogenous compounds or carbon dioxide and can be a metabolic byproduct or a degradation product (such as urobilin metabolised from bilirubin which is a degradation product of hemoglobin).

parent_id:7672

**level:3

type:child

term:Trace element

definition:A chemical element that occurs in very small amounts in organisms and is essential for many physiological and biochemical processes.В .

parent_id:7672

**level:3

type:child

synonym:Trace mineral

synonym:Essential mineral

状态
Solid
实验性质
1:

kind:water_solubility

value:162.0 mg/mL

source:

2:

kind:logp

value:-2.54

source:HANSCH,C ET AL. (1995)

3:

kind:melting_point

value:221 °C

source:

预测性质
1:

kind:logp

value:-2.71

source:ALOGPS

2:

kind:logs

value:0.50

source:ALOGPS

3:

kind:solubility

value:365 g/L

source:ALOGPS

4:

kind:logp

value:-2.6

source:ChemAxon

5:

kind:pka_strongest_acidic

value:1.94

source:ChemAxon

6:

kind:pka_strongest_basic

value:11.33

source:ChemAxon

7:

kind:iupac

value:(2S)-pyrrolidine-2-carboxylic acid

source:ChemAxon

8:

kind:average_mass

value:115.1305

source:ChemAxon

9:

kind:mono_mass

value:115.063328537

source:ChemAxon

10:

kind:smiles

value:OC(=O)[C@@H]1CCCN1

source:ChemAxon

11:

kind:formula

value:C5H9NO2

source:ChemAxon

12:

kind:inchi

value:InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1

source:ChemAxon

13:

kind:inchikey

value:ONIBWKKTOPOVIA-BYPYZUCNSA-N

source:ChemAxon

14:

kind:polar_surface_area

value:49.33

source:ChemAxon

15:

kind:refractivity

value:28.06

source:ChemAxon

16:

kind:polarizability

value:11.5

source:ChemAxon

17:

kind:rotatable_bond_count

value:1

source:ChemAxon

18:

kind:acceptor_count

value:3

source:ChemAxon

19:

kind:donor_count

value:2

source:ChemAxon

20:

kind:physiological_charge

value:0

source:ChemAxon

21:

kind:formal_charge

value:0

source:ChemAxon

22:

kind:number_of_rings

value:1

source:ChemAxon

23:

kind:bioavailability

value:Yes

source:ChemAxon

24:

kind:rule_of_five

value:Yes

source:ChemAxon

25:

kind:ghose_filter

value:No

source:ChemAxon

26:

kind:veber_rule

value:No

source:ChemAxon

27:

kind:mddr_like_rule

value:No

source:ChemAxon

1:

type:Specdb::NmrTwoD

spectrum_id:977

2:

type:Specdb::NmrTwoD

spectrum_id:1179

3:

type:Specdb::NmrOneD

spectrum_id:1122

4:

type:Specdb::NmrOneD

spectrum_id:1179

5:

type:Specdb::NmrOneD

spectrum_id:4872

6:

type:Specdb::NmrOneD

spectrum_id:142630

7:

type:Specdb::NmrOneD

spectrum_id:142631

8:

type:Specdb::NmrOneD

spectrum_id:142632

9:

type:Specdb::NmrOneD

spectrum_id:142633

10:

type:Specdb::NmrOneD

spectrum_id:142634

11:

type:Specdb::NmrOneD

spectrum_id:142635

12:

type:Specdb::NmrOneD

spectrum_id:142636

13:

type:Specdb::NmrOneD

spectrum_id:142637

14:

type:Specdb::NmrOneD

spectrum_id:142638

15:

type:Specdb::NmrOneD

spectrum_id:142639

16:

type:Specdb::NmrOneD

spectrum_id:142640

17:

type:Specdb::NmrOneD

spectrum_id:142641

18:

type:Specdb::NmrOneD

spectrum_id:142642

19:

type:Specdb::NmrOneD

spectrum_id:142643

20:

type:Specdb::NmrOneD

spectrum_id:142644

21:

type:Specdb::NmrOneD

spectrum_id:142645

22:

type:Specdb::NmrOneD

spectrum_id:142646

23:

type:Specdb::NmrOneD

spectrum_id:142647

24:

type:Specdb::NmrOneD

spectrum_id:142648

25:

type:Specdb::NmrOneD

spectrum_id:142649

26:

type:Specdb::NmrOneD

spectrum_id:166490

27:

type:Specdb::MsMs

spectrum_id:254

28:

type:Specdb::MsMs

spectrum_id:255

29:

type:Specdb::MsMs

spectrum_id:256

30:

type:Specdb::MsMs

spectrum_id:3233

31:

type:Specdb::MsMs

spectrum_id:3234

32:

type:Specdb::MsMs

spectrum_id:3235

33:

type:Specdb::MsMs

spectrum_id:3236

34:

type:Specdb::MsMs

spectrum_id:3237

35:

type:Specdb::MsMs

spectrum_id:3238

36:

type:Specdb::MsMs

spectrum_id:3239

37:

type:Specdb::MsMs

spectrum_id:3240

38:

type:Specdb::MsMs

spectrum_id:3241

39:

type:Specdb::MsMs

spectrum_id:3242

40:

type:Specdb::MsMs

spectrum_id:3243

41:

type:Specdb::MsMs

spectrum_id:3244

42:

type:Specdb::MsMs

spectrum_id:3245

43:

type:Specdb::MsMs

spectrum_id:3246

44:

type:Specdb::MsMs

spectrum_id:3247

45:

type:Specdb::MsMs

spectrum_id:3248

46:

type:Specdb::MsMs

spectrum_id:3249

47:

type:Specdb::MsMs

spectrum_id:3254

48:

type:Specdb::MsMs

spectrum_id:3255

49:

type:Specdb::MsMs

spectrum_id:3256

50:

type:Specdb::MsMs

spectrum_id:3257

51:

type:Specdb::MsMs

spectrum_id:178125

52:

type:Specdb::CMs

spectrum_id:395

53:

type:Specdb::CMs

spectrum_id:396

54:

type:Specdb::CMs

spectrum_id:397

55:

type:Specdb::CMs

spectrum_id:398

56:

type:Specdb::CMs

spectrum_id:949

57:

type:Specdb::CMs

spectrum_id:1027

58:

type:Specdb::CMs

spectrum_id:1046

59:

type:Specdb::CMs

spectrum_id:2426

60:

type:Specdb::CMs

spectrum_id:29555

61:

type:Specdb::CMs

spectrum_id:30077

62:

type:Specdb::CMs

spectrum_id:30380

63:

type:Specdb::CMs

spectrum_id:30381

64:

type:Specdb::CMs

spectrum_id:30608

65:

type:Specdb::CMs

spectrum_id:30729

66:

type:Specdb::CMs

spectrum_id:30799

67:

type:Specdb::CMs

spectrum_id:31035

68:

type:Specdb::CMs

spectrum_id:31036

69:

type:Specdb::CMs

spectrum_id:31037

70:

type:Specdb::CMs

spectrum_id:37331

71:

type:Specdb::CMs

spectrum_id:156130

光谱
生物学性质
1:

cellular:(1):Cytoplasm

cellular:(2):Endoplasmic reticulum

cellular:(3):Extracellular

cellular:(4):Lysosome

cellular:(5):Mitochondria

2:

biospecimen:(1):Blood

biospecimen:(2):Breast Milk

biospecimen:(3):Cerebrospinal Fluid (CSF)

biospecimen:(4):Feces

biospecimen:(5):Saliva

biospecimen:(6):Sweat

biospecimen:(7):Urine

3:

tissue:(1):All Tissues

tissue:(2):Placenta

tissue:(3):Prostate

4:

[1]:

name:Amikacin Action Pathway

smpdb_id:SMP00253

kegg_map_id:

[2]:

name:Arbekacin Action Pathway

smpdb_id:SMP00713

kegg_map_id:

[3]:

name:Arginine and proline metabolism

smpdb_id:

kegg_map_id:map00330

[4]:

name:Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency)

smpdb_id:SMP00362

kegg_map_id:

[5]:

name:Azithromycin Action Pathway

smpdb_id:SMP00247

kegg_map_id:

[6]:

name:Chloramphenicol Action Pathway

smpdb_id:SMP00729

kegg_map_id:

[7]:

name:Clarithromycin Action Pathway

smpdb_id:SMP00248

kegg_map_id:

[8]:

name:Clindamycin Action Pathway

smpdb_id:SMP00249

kegg_map_id:

[9]:

name:Clomocycline Action Pathway

smpdb_id:SMP00262

kegg_map_id:

[10]:

name:Creatine deficiency, guanidinoacetate methyltransferase deficiency

smpdb_id:SMP00504

kegg_map_id:

[11]:

name:Demeclocycline Action Pathway

smpdb_id:SMP00290

kegg_map_id:

[12]:

name:Doxycycline Action Pathway

smpdb_id:SMP00291

kegg_map_id:

[13]:

name:Erythromycin Action Pathway

smpdb_id:SMP00250

kegg_map_id:

[14]:

name:Gentamicin Action Pathway

smpdb_id:SMP00254

kegg_map_id:

[15]:

name:Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency)

smpdb_id:SMP00188

kegg_map_id:

[16]:

name:Hyperornithinemia with gyrate atrophy (HOGA)

smpdb_id:SMP00505

kegg_map_id:

[17]:

name:Hyperornithinemia-hyperammonemia-homocitrullinuria [HHH-syndrome]

smpdb_id:SMP00506

kegg_map_id:

[18]:

name:Hyperprolinemia Type I

smpdb_id:SMP00361

kegg_map_id:

[19]:

name:Hyperprolinemia Type II

smpdb_id:SMP00360

kegg_map_id:

[20]:

name:Josamycin Action Pathway

smpdb_id:SMP00731

kegg_map_id:

[21]:

name:Kanamycin Action Pathway

smpdb_id:SMP00255

kegg_map_id:

[22]:

name:L-arginine:glycine amidinotransferase deficiency

smpdb_id:SMP00507

kegg_map_id:

[23]:

name:Lincomycin Action Pathway

smpdb_id:SMP00728

kegg_map_id:

[24]:

name:Lymecycline Action Pathway

smpdb_id:SMP00295

kegg_map_id:

[25]:

name:Methacycline Action Pathway

smpdb_id:SMP00727

kegg_map_id:

[26]:

name:Minocycline Action Pathway

smpdb_id:SMP00292

kegg_map_id:

[27]:

name:Neomycin Action Pathway

smpdb_id:SMP00256

kegg_map_id:

[28]:

name:Netilmicin Action Pathway

smpdb_id:SMP00257

kegg_map_id:

[29]:

name:Ornithine Aminotransferase Deficiency (OAT Deficiency)

smpdb_id:SMP00363

kegg_map_id:

[30]:

name:Oxytetracycline Action Pathway

smpdb_id:SMP00293

kegg_map_id:

[31]:

name:Paromomycin Action Pathway

smpdb_id:SMP00714

kegg_map_id:

[32]:

name:Prolidase Deficiency (PD)

smpdb_id:SMP00207

kegg_map_id:

[33]:

name:Prolinemia Type II

smpdb_id:SMP00208

kegg_map_id:

[34]:

name:Rolitetracycline Action Pathway

smpdb_id:SMP00726

kegg_map_id:

[35]:

name:Roxithromycin Action Pathway

smpdb_id:SMP00251

kegg_map_id:

[36]:

name:Spectinomycin Action Pathway

smpdb_id:SMP00258

kegg_map_id:

[37]:

name:Streptomycin Action Pathway

smpdb_id:SMP00259

kegg_map_id:

[38]:

name:Telithromycin Action Pathway

smpdb_id:SMP00252

kegg_map_id:

[39]:

name:Tetracycline Action Pathway

smpdb_id:SMP00294

kegg_map_id:

[40]:

name:The Oncogenic Action of Fumarate

smpdb_id:SMP02295

kegg_map_id:

[41]:

name:The Oncogenic Action of Succinate

smpdb_id:SMP02292

kegg_map_id:

[42]:

name:Tigecycline Action Pathway

smpdb_id:SMP00712

kegg_map_id:

[43]:

name:Tobramycin Action Pathway

smpdb_id:SMP00711

kegg_map_id:

[44]:

name:Transcription/Translation

smpdb_id:SMP00019

kegg_map_id:

[45]:

name:Troleandomycin Action Pathway

smpdb_id:SMP00730

kegg_map_id:

正常浓度
1:

biospecimen:Blood

concentration_value:198.3 +/- 64.8

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

2:

biospecimen:Blood

concentration_value:168.0 (108.0-228.0)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

3:

biospecimen:Blood

concentration_value:177.5 +/- 38.6

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

4:

biospecimen:Blood

concentration_value:111-329

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

5:

biospecimen:Blood

concentration_value:77-324

concentration_units:uM

subject_age:Infant (1 - 3 months old)

subject_sex:Both

subject_condition:Normal

6:

biospecimen:Blood

concentration_value:40-332

concentration_units:uM

subject_age:Children (3 months - 6 years old)

subject_sex:Both

subject_condition:Normal

7:

biospecimen:Blood

concentration_value:58-324

concentration_units:uM

subject_age:Children (6 - 18 years old)

subject_sex:Both

subject_condition:Normal

8:

biospecimen:Blood

concentration_value:198.0 +/- 63.0

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Male

subject_condition:Normal

9:

biospecimen:Blood

concentration_value:239.0 +/- 70.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

10:

biospecimen:Blood

concentration_value:168.0 +/- 49.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

11:

biospecimen:Blood

concentration_value:61-285

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

12:

biospecimen:Blood

concentration_value:230.0 +/- 75.0

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Not Specified

subject_condition:Normal

13:

biospecimen:Blood

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

14:

biospecimen:Blood

concentration_value:211 (184-247)

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:

subject_condition:Normal

15:

biospecimen:Blood

concentration_value:180 +/- 47

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

16:

biospecimen:Blood

concentration_value:51-271

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

17:

biospecimen:Blood

concentration_value:93-233

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

18:

biospecimen:Blood

concentration_value:222 (159-278)

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

19:

biospecimen:Blood

concentration_value:193 +/- 52

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

20:

biospecimen:Blood

concentration_value:256 (207-310)

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:

subject_condition:Normal

21:

biospecimen:Blood

concentration_value:178 +/- 33

concentration_units:uM

subject_age:Children (1 - 13 years old)

subject_sex:Both

subject_condition:Normal

22:

biospecimen:Blood

concentration_value:105.0-360.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

23:

biospecimen:Blood

concentration_value:188.3 +/- 55.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

24:

biospecimen:Blood

concentration_value:179.7(156.2-221.1)

concentration_units:uM

subject_age:Children (1-13 uears old)

subject_sex:Both

subject_condition:Normal

25:

biospecimen:Blood

concentration_value:258.91 +/- 91

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Both

subject_condition:Normal

26:

biospecimen:Breast Milk

concentration_value:27.2 +/- 20.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

27:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value: 4.0 (0 - 8.0)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

28:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.6

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

29:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:1.9 +/- 1.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

30:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0-3

concentration_units:uM

subject_age:Children (0 - 10 years old)

subject_sex:Both

subject_condition:Normal

31:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0-3

concentration_units:uM

subject_age:Adolescent (>11 years old)

subject_sex:Both

subject_condition:Normal

32:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

33:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

34:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Children (1-13 years old)

subject_sex:Both

subject_condition:Normal

35:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

36:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Not Specified

subject_sex:Both

subject_condition:Normal

37:

biospecimen:Feces

concentration_value:9641.233 (5153.572-14128.894)

concentration_units:nmol/g wet feces

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

38:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Children (1-13 years old)

subject_sex:Both

subject_condition:Normal

39:

biospecimen:Feces

concentration_value:15258.0478 (7151.305-23364.790)

concentration_units:nmol/g wet feces

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

40:

biospecimen:Feces

concentration_value:20643.241 (12681.262-28605.220)

concentration_units:nmol/g wet feces

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

41:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Children (6 - 18 years old)

subject_sex:Not Specified

subject_condition:Normal

42:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

43:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

44:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

45:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

46:

biospecimen:Feces

concentration_value:19.109 +/- 10.0755

concentration_units:nmol/g wet feces

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

47:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

48:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

49:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

50:

biospecimen:Feces

concentration_value:950.226 +/- 727.870

concentration_units:nmol/g wet feces

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

51:

biospecimen:Feces

concentration_value:510 +/- 430

concentration_units:nmol/g wet feces

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

52:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

53:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

54:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

55:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

56:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

57:

biospecimen:Feces

concentration_value:180 +/- 160

concentration_units:nmol/g wet feces

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

58:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

59:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

60:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

61:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

62:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

63:

biospecimen:Saliva

concentration_value:118 +/- 125

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

64:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

65:

biospecimen:Saliva

concentration_value:18.8 +/- 13.5

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

66:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

67:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

68:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

69:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

70:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

71:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

72:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

73:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

74:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

75:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

76:

biospecimen:Saliva

concentration_value:11.4 +/- 9.9

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

77:

biospecimen:Saliva

concentration_value:6.1 +/- 5.3

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

78:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

79:

biospecimen:Saliva

concentration_value:6.0 +/- 2.6

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

80:

biospecimen:Saliva

concentration_value:158.48 +/- 122.10

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

81:

biospecimen:Saliva

concentration_value:9.5 +/- 10.5

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

82:

biospecimen:Saliva

concentration_value:96.85 +/- 74.83

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

83:

biospecimen:Saliva

concentration_value:>10

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

84:

biospecimen:Sweat

concentration_value:< 10

concentration_units:uM

subject_age:Adult (60 years old)

subject_sex:Male

subject_condition:Normal

85:

biospecimen:Sweat

concentration_value:< 10

concentration_units:uM

subject_age:Adult (40 years old)

subject_sex:Male

subject_condition:Normal

86:

biospecimen:Urine

concentration_value:<2.26

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

87:

biospecimen:Urine

concentration_value:0.86

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

88:

biospecimen:Urine

concentration_value:<3.17

concentration_units:umol/mmol creatinine

subject_age:Adolescent (13-18 years old)

subject_sex:Not Specified

subject_condition:Normal

89:

biospecimen:Urine

concentration_value:39.537 +/- 19.358

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

90:

biospecimen:Urine

concentration_value:<6.08-34.76

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

91:

biospecimen:Urine

concentration_value:0.39-0.85

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

92:

biospecimen:Urine

concentration_value:<2.94

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

93:

biospecimen:Urine

concentration_value:3.17-229.48

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

94:

biospecimen:Urine

concentration_value:0

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

95:

biospecimen:Urine

concentration_value:0

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

96:

biospecimen:Urine

concentration_value:<2.0

concentration_units:umol/mmol creatinine

subject_age:Infant (6 months - <1 year old)

subject_sex:Both

subject_condition:Normal

97:

biospecimen:Urine

concentration_value:0

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

98:

biospecimen:Urine

concentration_value:<9.0

concentration_units:umol/mmol creatinine

subject_age:Infant (1 - 6 months old)

subject_sex:Both

subject_condition:Normal

99:

biospecimen:Urine

concentration_value:3.6 +/- 1.4

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

100:

biospecimen:Urine

concentration_value:0-3

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

101:

biospecimen:Urine

concentration_value:3.06 /- 1.87

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

102:

biospecimen:Urine

concentration_value:2.171 (0.0658-4.276)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

103:

biospecimen:Urine

concentration_value:1.1 (0.1-2.5)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

104:

biospecimen:Urine

concentration_value:<13.46

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

105:

biospecimen:Urine

concentration_value:84.89 (34.67-135.11)

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

106:

biospecimen:Urine

concentration_value:21.93 - 220.92

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

107:

biospecimen:Urine

concentration_value:0 - 134.88

concentration_units:umol/mmol creatinine

subject_age:Infant (1 - 6 months old)

subject_sex:Both

subject_condition:Normal

108:

biospecimen:Urine

concentration_value:0 - 14.70

concentration_units:umol/mmol creatinine

subject_age:Infant (6 months - <1 year old)

subject_sex:Both

subject_condition:Normal

109:

biospecimen:Urine

concentration_value:0 - 13.57

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 2 years old)

subject_sex:Both

subject_condition:Normal

110:

biospecimen:Urine

concentration_value:0 - 9.50

concentration_units:umol/mmol creatinine

subject_age:Children (2 - 4 years old)

subject_sex:Both

subject_condition:Normal

111:

biospecimen:Urine

concentration_value:0 - 9.50

concentration_units:umol/mmol creatinine

subject_age:Children (4 - 13 years old)

subject_sex:Both

subject_condition:Normal

112:

biospecimen:Urine

concentration_value:0 - 9.50

concentration_units:umol/mmol creatinine

subject_age:Adolescent (13 - 21 years old)

subject_sex:Both

subject_condition:Normal

113:

biospecimen:Urine

concentration_value:0 - 9.50

concentration_units:umol/mmol creatinine

subject_age:Adult (>21 years old)

subject_sex:Both

subject_condition:Normal

114:

biospecimen:Urine

concentration_value:8-260

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

115:

biospecimen:Urine

concentration_value:8-260

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

116:

biospecimen:Urine

concentration_value:0.41-0.66

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

117:

biospecimen:Urine

concentration_value:248.73 +/- 180.90

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

118:

biospecimen:Urine

concentration_value:440.93 +/- 260.04

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

119:

biospecimen:Urine

concentration_value:508.77 +/- 237.43

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

120:

biospecimen:Urine

concentration_value:4.14 +/- 2.85

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

121:

biospecimen:Urine

concentration_value:0.5

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

122:

biospecimen:Urine

concentration_value:<8.82

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

123:

biospecimen:Urine

concentration_value:2.4998 +/- 0.8786

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

124:

biospecimen:Urine

concentration_value:9.5-78.2

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

125:

biospecimen:Urine

concentration_value:22.36(12.65-53.64)

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Female

subject_condition:Normal

126:

biospecimen:Urine

concentration_value:23(9.49-82.39)

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Male

subject_condition:Normal

127:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

异常浓度
1:

biospecimen:Blood

concentration_value:164.6 +/- 49.5

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Obesity

2:

biospecimen:Blood

concentration_value:197.2 +/- 71.5

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Obesity

3:

biospecimen:Blood

concentration_value:159.9 +/- 86.3

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Heart Transplant

4:

biospecimen:Blood

concentration_value:208.459-1745.845

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Hyperprolinemia, type I

5:

biospecimen:Blood

concentration_value:135.31 +/- 42.98

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy with fetuses with trisomy 18

6:

biospecimen:Blood

concentration_value:125.42 +/- 48.53

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

7:

biospecimen:Blood

concentration_value:138.6 (52.0)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Early preeclampsia

8:

biospecimen:Blood

concentration_value:142.6 (58.5)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

9:

biospecimen:Blood

concentration_value:417.5 (179-576)

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Male

patient_information:Lipoyltransferase 1 Deficiency

10:

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

11:

biospecimen:Blood

concentration_value:201.0 +/- 149.5

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Hemodialysis

12:

biospecimen:Blood

concentration_value:227.2 +/- 108.4

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Hemodialysis

13:

biospecimen:Blood

concentration_value:390.861

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Male

patient_information:Dihydrolipoamide Dehydrogenase Deficiency

14:

biospecimen:Blood

concentration_value:>1500

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Not Specified

patient_information:Hyperprolinemia, type II

15:

biospecimen:Blood

concentration_value:801

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:

patient_information:Pyruvate carboxylase deficiency

16:

biospecimen:Blood

concentration_value:91 +/- 18

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Cutis laxa, autosomal recessive, type IIIA

17:

biospecimen:Blood

concentration_value:212 (70-388)

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Male

patient_information:Dicarboxylic Aminoaciduria

18:

biospecimen:Blood

concentration_value:149-233

concentration_units:uM

patient_age:Newborn (0-30 days old)

patient_sex:Female

patient_information:Mitochondrial pyruvate carrier deficiency

19:

biospecimen:Blood

concentration_value:114

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:

patient_information:Pyruvate carboxylase deficiency

20:

biospecimen:Blood

concentration_value:159 +/- 47

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Obese

21:

biospecimen:Blood

concentration_value:166 +/- 46

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Obese

22:

biospecimen:Blood

concentration_value:154 +/- 48

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Obese

23:

biospecimen:Blood

concentration_value:163 +/- 47

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Obese

24:

biospecimen:Blood

concentration_value:111.43 (37.73)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy with fetus having congenital heart defect

25:

biospecimen:Blood

concentration_value:106 (33.59)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

26:

biospecimen:Blood

concentration_value:650.00 (300.00-1000.00)

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Glutathione synthetase deficiency

27:

biospecimen:Blood

concentration_value:108-533

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Both

patient_information:Iminoglycinuria

28:

biospecimen:Blood

concentration_value:172.2 (57.7)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Late-onset preeclampsia

29:

biospecimen:Blood

concentration_value:165.7 (56.4)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

30:

biospecimen:Blood

concentration_value:191.5(163.3-226.4)

concentration_units:uM

patient_age:Children (1-13 uears old)

patient_sex:Both

patient_information:Environmental enteric dysfunction

31:

biospecimen:Blood

concentration_value:180.88 +/- 63.23

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Obese

32:

biospecimen:Blood

concentration_value:142.2 (60.4)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Down syndrome pregnancy

33:

biospecimen:Blood

concentration_value:134.0 (52.4)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

34:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Male

patient_information:Dicarboxylic Aminoaciduria

35:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.68 +/- 0.35

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Alzheimer's disease

36:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

37:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

38:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal Cancer

39:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Autism

40:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Immunoglobulin A nephropathy (IgAN) progressor

41:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:ankylosing spondylitis

42:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:rheumatoid arthritis

43:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:celiac disease

44:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

45:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Crohns disease

46:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Ulcerative colitis

47:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Unclassified IBD

48:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Irritable bowel syndrome

49:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Ulcerative colitis

50:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

51:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

52:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

53:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (1-13 years old)

patient_sex:Not Specified

patient_information:celiac disease

54:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal Cancer

55:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (1-13 years old)

patient_sex:Not Specified

patient_information:Treated celiac disease

56:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

57:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Attachment loss 

58:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Missing teeth

59:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Periodontal Probing Depth

60:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Tooth Decay

61:

biospecimen:Saliva

concentration_value:77.33 +/- 4.56

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Alzheimer's disease

62:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Oral cancer

63:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Breast cancer

64:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Not Specified

patient_information:Pancreatic cancer

65:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Not Specified

patient_information:Periodontal diseases

66:

biospecimen:Saliva

concentration_value:48.08 +/- 21.24

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Frontotemporal lobe dementia

67:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Oral squamous cell carcinoma (OSCC)

68:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Oral leukoplakia (OLK)

69:

biospecimen:Saliva

concentration_value:72.05 +/- 35.86

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Lewy body disease

70:

biospecimen:Urine

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Bladder cancer

71:

biospecimen:Urine

concentration_value:32.039 +/- 36.94

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Eosinophilic esophagitis

72:

biospecimen:Urine

concentration_value:0.0068 - 0.0549

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:ADPKD

73:

biospecimen:Urine

concentration_value:0

concentration_units:umol/mmol creatinine

patient_age:Adolescent (13-18 years old)

patient_sex:Both

patient_information:Hyperglycinuria

74:

biospecimen:Urine

concentration_value:0-1

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Hyperglycinuria

75:

biospecimen:Urine

concentration_value:0-1037

concentration_units:umol/mmol creatinine

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Iminoglycinuria

76:

biospecimen:Urine

concentration_value:163-259

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Iminoglycinuria

77:

biospecimen:Urine

concentration_value:29.6 (19.7-39.47)

concentration_units:umol/mmol creatinine

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Iminoglycinuria

78:

biospecimen:Urine

concentration_value:3.6454 +/- 3.3038

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Eosinophilic esophagitis

79:

biospecimen:Urine

concentration_value:2.6335 +/- 1.9039

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Gastroesophageal reflux disease

疾病参考
1:

name:Hemodialysis

omim_id:

[1]:

reference_text:Hung SC, Hung SH, Tarng DC, Yang WC, Chen TW, Huang TP: Thiamine deficiency and unexplained encephalopathy in hemodialysis and peritoneal dialysis patients. Am J Kidney Dis. 2001 Nov;38(5):941-7.

pubmed_id:11684545

[2]:

reference_text:Gill DS, Fonseca VA, Barradas MA, Balliod R, Moorhead JF, Dandona P: Plasma histamine in patients with chronic renal failure and nephrotic syndrome. J Clin Pathol. 1991 Mar;44(3):243-5.

pubmed_id:2013627

[3]:

reference_text:Pawlak D, Pawlak K, Malyszko J, Mysliwiec M, Buczko W: Accumulation of toxic products degradation of kynurenine in hemodialyzed patients. Int Urol Nephrol. 2001;33(2):399-404.

pubmed_id:12092667

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reference_text:Ogawa Y, Machida N, Jahana M, Gakiya M, Chinen Y, Oda M, Morozumi M, Sugaya K: Major factors modulating the serum oxalic acid level in hemodialysis patients. Front Biosci. 2004 Sep 1;9:2901-8.

pubmed_id:15353324

[5]:

reference_text:Raj DS, Ouwendyk M, Francoeur R, Pierratos A: Plasma amino acid profile on nocturnal hemodialysis. Blood Purif. 2000;18(2):97-102.

pubmed_id:10838467

[6]:

reference_text:Cabral PC, Diniz Ada S, de Arruda IK: Vitamin A and zinc status in patients on maintenance haemodialysis. Nephrology (Carlton). 2005 Oct;10(5):459-63.

pubmed_id:16221095

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reference_text:Oikawa O, Higuchi T, Yamazaki T, Yamamoto C, Fukuda N, Matsumoto K: Evaluation of serum fetuin-A relationships with biochemical parameters in patients on hemodialysis. Clin Exp Nephrol. 2007 Dec;11(4):304-8. Epub 2007 Dec 21.

pubmed_id:18085392

[8]:

reference_text:Pollack GM, Buchanan JF, Slaughter RL, Kohli RK, Shen DD: Circulating concentrations of di(2-ethylhexyl) phthalate and its de-esterified phthalic acid products following plasticizer exposure in patients receiving hemodialysis. Toxicol Appl Pharmacol. 1985 Jun 30;79(2):257-67.

pubmed_id:4002227

[9]:

reference_text:De Smet R, Van Kaer J, Liebich H, Lesaffer G, Verstraete A, Dhondt A, Duym P, Lameire N, Vanholder R: Heparin-induced release of protein-bound solutes during hemodialysis is an in vitro artifact. Clin Chem. 2001 May;47(5):901-9.

pubmed_id:11325895

[10]:

reference_text:Jankowski J, Jankowski V, Laufer U, van der Giet M, Henning L, Tepel M, Zidek W, Schluter H: Identification and quantification of diadenosine polyphosphate concentrations in human plasma. Arterioscler Thromb Vasc Biol. 2003 Jul 1;23(7):1231-8. Epub 2003 May 8.

pubmed_id:12738682

[11]:

reference_text:Pham NM, Recht NS, Hostetter TH, Meyer TW: Removal of the protein-bound solutes indican and p-cresol sulfate by peritoneal dialysis. Clin J Am Soc Nephrol. 2008 Jan;3(1):85-90. Epub 2007 Nov 28.

pubmed_id:18045861

[12]:

reference_text:McGregor DO, Dellow WJ, Lever M, George PM, Robson RA, Chambers ST: Dimethylglycine accumulates in uremia and predicts elevated plasma homocysteine concentrations. Kidney Int. 2001 Jun;59(6):2267-72.

pubmed_id:11380830

2:

name:Glutathione synthetase deficiency

omim_id:266130

[1]:

reference_text:Mayatepek E, Meissner T, Grobe H: Acute metabolic crisis with extreme deficiency of glutathione in combination with decreased levels of leukotriene C4 in a patient with glutathione synthetase deficiency. J Inherit Metab Dis. 2004;27(2):297-9.

pubmed_id:15243994

[2]:

reference_text:Li X, Ding Y, Liu Y, Ma Y, Song J, Wang Q, Yang Y: Five Chinese patients with 5-oxoprolinuria due to glutathione synthetase and 5-oxoprolinase deficiencies. Brain Dev. 2015 Nov;37(10):952-9. doi: 10.1016/j.braindev.2015.03.005. Epub 2015 Apr 4.

pubmed_id:25851806

[3]:

reference_text:MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de)

pubmed_id:

3:

name:Early preeclampsia

omim_id:

[1]:

reference_text:Bahado-Singh RO, Akolekar R, Mandal R, Dong E, Xia J, Kruger M, Wishart DS, Nicolaides K: Metabolomics and first-trimester prediction of early-onset preeclampsia. J Matern Fetal Neonatal Med. 2012 Oct;25(10):1840-7. doi: 10.3109/14767058.2012.680254. Epub 2012 Apr 28.

pubmed_id:22494326

4:

name:Pregnancy

omim_id:

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reference_text:Yang XL, Wu XR: The dynamic changes of several reproductive hormones during termination of early pregnancy by RU486 in combination with PG-05 in Chinese women. Adv Contracept. 1988 Dec;4(4):319-26.

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reference_text:Ball P, Emons G, Haupt O, Hoppen HO, Knuppen R: Radioimmunoassay of 2-hydroxyestrone. Steroids. 1978 Feb;31(2):249-58.

pubmed_id:663967

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reference_text:Yang YJ, Lee J, Choi MH, Chung BC: Direct determination of estriol 3- and 16-glucuronides in pregnancy urine by column-switching liquid chromatography with electrospray tandem mass spectrometry. Biomed Chromatogr. 2003 Jun;17(4):219-25.

pubmed_id:12833386

[4]:

reference_text:Andreolini F, Borra C, Caccamo F, Di Corcia A, Nicoletti I, Samperi R, Improta F: Estriol and its conjugates in late pregnancy determined by extraction with Carbopack B and liquid chromatography with fluorometric detection. Clin Chem. 1985 Oct;31(10):1698-702.

pubmed_id:2994907

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reference_text:Huang PC, Kuo PL, Guo YL, Liao PC, Lee CC: Associations between urinary phthalate monoesters and thyroid hormones in pregnant women. Hum Reprod. 2007 Oct;22(10):2715-22. Epub 2007 Aug 17.

pubmed_id:17704099

[6]:

reference_text:Ribar S, Mesaric M, Sedic M: Sphingoid bases as possible diagnostic parameters. Croat Med J. 2003 Apr;44(2):165-70.

pubmed_id:12698507

[7]:

reference_text:Khan HA, Sobki SH, Alhomida AS: Fluctuations in fasting blood glucose and serum fructosamine in pregnant women monitored on successive antenatal visits. Clin Exp Med. 2006 Oct;6(3):134-7.

pubmed_id:17061063

[8]:

reference_text:Mikkelsen TB, Osler M, Olsen SF: Validity of protein, retinol, folic acid and n-3 fatty acid intakes estimated from the food-frequency questionnaire used in the Danish National Birth Cohort. Public Health Nutr. 2006 Sep;9(6):771-8.

pubmed_id:16925883

[9]:

reference_text:Shiraishi M, Haruna M, Matsuzaki M, Murayama R, Sasaki S, Murashima S: Validity and reproducibility of folate and vitamin B(12) intakes estimated from a self-administered diet history questionnaire in Japanese pregnant women. Nutr J. 2012 Mar 15;11:15. doi: 10.1186/1475-2891-11-15.

pubmed_id:22420377

[10]:

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pubmed_id:17269711

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pubmed_id:23516449

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pubmed_id:23867873

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pubmed_id:24811995

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pubmed_id:25598765

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pubmed_id:26806034

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pubmed_id:26848182

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reference_text:Kolho KL, Pessia A, Jaakkola T, de Vos WM, Velagapudi V: Faecal and Serum Metabolomics in Paediatric Inflammatory Bowel Disease. J Crohns Colitis. 2017 Mar 1;11(3):321-334. doi: 10.1093/ecco-jcc/jjw158.

pubmed_id:27609529

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name:Periodontal disease

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pubmed_id:20300169

26:

name:Frontotemporal dementia

omim_id:600274

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reference_text:Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6.

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27:

name:Lewy body disease

omim_id:

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28:

name:Attachment loss

omim_id:

[1]:

reference_text:Liebsch C, Pitchika V, Pink C, Samietz S, Kastenmuller G, Artati A, Suhre K, Adamski J, Nauck M, Volzke H, Friedrich N, Kocher T, Holtfreter B, Pietzner M: The Saliva Metabolome in Association to Oral Health Status. J Dent Res. 2019 Jun;98(6):642-651. doi: 10.1177/0022034519842853. Epub 2019 Apr 26.

pubmed_id:31026179

29:

name:Missing teeth

omim_id:

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reference_text:Liebsch C, Pitchika V, Pink C, Samietz S, Kastenmuller G, Artati A, Suhre K, Adamski J, Nauck M, Volzke H, Friedrich N, Kocher T, Holtfreter B, Pietzner M: The Saliva Metabolome in Association to Oral Health Status. J Dent Res. 2019 Jun;98(6):642-651. doi: 10.1177/0022034519842853. Epub 2019 Apr 26.

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30:

name:Periodontal Probing Depth

omim_id:

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reference_text:Liebsch C, Pitchika V, Pink C, Samietz S, Kastenmuller G, Artati A, Suhre K, Adamski J, Nauck M, Volzke H, Friedrich N, Kocher T, Holtfreter B, Pietzner M: The Saliva Metabolome in Association to Oral Health Status. J Dent Res. 2019 Jun;98(6):642-651. doi: 10.1177/0022034519842853. Epub 2019 Apr 26.

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31:

name:Tooth Decay

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reference_text:Liebsch C, Pitchika V, Pink C, Samietz S, Kastenmuller G, Artati A, Suhre K, Adamski J, Nauck M, Volzke H, Friedrich N, Kocher T, Holtfreter B, Pietzner M: The Saliva Metabolome in Association to Oral Health Status. J Dent Res. 2019 Jun;98(6):642-651. doi: 10.1177/0022034519842853. Epub 2019 Apr 26.

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32:

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pubmed_id:19033659

[3]:

reference_text:MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de)

pubmed_id:

33:

name:Autosomal dominant polycystic kidney disease

omim_id:601313

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34:

name:Eosinophilic esophagitis

omim_id:610247

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reference_text:Mordechai, Hien, and David S. Wishart

pubmed_id:

KEGG数据库编号
C00148
DrugBank数据库编号
DB00172
foodb数据库编号
FDB000570
ChemSpider数据库编号
128566
公共化学化合物编号
145742
PDB数据库编号
生物利益的化学实体数据库编号
17203
knapsack数据库编号
C00001388
维基百科编号
L-proline
代谢途径的数据库编号
PRO
苯酚资源管理器化合物数据库编号
比格数据库编号
34042
梅林编号
29
虚拟机身份证编号
PRO_L
fbonto数据库编号
综合参考
Itoh, Tamio. Synthesis of L-proline from L-glutamine. Bulletin of the Chemical Society of Japan (1963), 36(1), 25-9
一般参考
1:

protein_accession:HMDBP00302

name:Prolyl 4-hydroxylase subunit alpha-2

uniprot_id:O15460

gene_name:P4HA2

protein_type:Enzyme

2:

protein_accession:HMDBP00303

name:Pyrroline-5-carboxylate reductase 1, mitochondrial

uniprot_id:P32322

gene_name:PYCR1

protein_type:Unknown

3:

protein_accession:HMDBP00304

name:Prolyl 4-hydroxylase subunit alpha-1

uniprot_id:P13674

gene_name:P4HA1

protein_type:Enzyme

4:

protein_accession:HMDBP00305

name:Pyrroline-5-carboxylate reductase 2

uniprot_id:Q96C36

gene_name:PYCR2

protein_type:Unknown

5:

protein_accession:HMDBP00567

name:Bifunctional glutamate/proline--tRNA ligase

uniprot_id:P07814

gene_name:EPRS

protein_type:Enzyme

6:

protein_accession:HMDBP00865

name:Cytosol aminopeptidase

uniprot_id:P28838

gene_name:LAP3

protein_type:Unknown

7:

protein_accession:HMDBP02042

name:Proline dehydrogenase 1, mitochondrial

uniprot_id:O43272

gene_name:PRODH

protein_type:Unknown

8:

protein_accession:HMDBP02972

name:Pyrroline-5-carboxylate reductase 3

uniprot_id:Q53H96

gene_name:PYCRL

protein_type:Unknown

9:

protein_accession:HMDBP03037

name:Proline synthase co-transcribed bacterial homolog protein

uniprot_id:O94903

gene_name:PROSC

protein_type:Enzyme

10:

protein_accession:HMDBP03153

name:Pyrroline-5-carboxylate reductase

uniprot_id:Q4W8W1

gene_name:P5CR2

protein_type:Enzyme

11:

protein_accession:HMDBP03259

name:Sodium-dependent proline transporter

uniprot_id:Q99884

gene_name:SLC6A7

protein_type:Unknown

12:

protein_accession:HMDBP03302

name:Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

uniprot_id:Q9UN76

gene_name:SLC6A14

protein_type:Unknown

13:

protein_accession:HMDBP05340

name:Monocarboxylate transporter 10

uniprot_id:Q8TF71

gene_name:SLC16A10

protein_type:Transporter

14:

protein_accession:HMDBP05360

name:Probable proline dehydrogenase 2

uniprot_id:Q9UF12

gene_name:PRODH2

protein_type:Unknown

15:

protein_accession:HMDBP08080

name:Transient receptor potential cation channel subfamily M member 1

uniprot_id:Q7Z4N2

gene_name:TRPM1

protein_type:Unknown

16:

protein_accession:HMDBP08681

name:Prolyl 3-hydroxylase 1

uniprot_id:Q32P28

gene_name:LEPRE1

protein_type:Unknown

17:

protein_accession:HMDBP08682

name:Prolyl 3-hydroxylase 2

uniprot_id:Q8IVL5

gene_name:LEPREL1

protein_type:Unknown

18:

protein_accession:HMDBP08683

name:Prolyl 3-hydroxylase 3

uniprot_id:Q8IVL6

gene_name:LEPREL2

protein_type:Unknown

19:

protein_accession:HMDBP09111

name:Prolyl 4-hydroxylase subunit alpha-3

uniprot_id:Q7Z4N8

gene_name:P4HA3

protein_type:Enzyme

20:

protein_accession:HMDBP09210

name:Egl nine homolog 1

uniprot_id:Q9GZT9

gene_name:EGLN1

protein_type:Enzyme

21:

protein_accession:HMDBP09211

name:Egl nine homolog 2

uniprot_id:Q96KS0

gene_name:EGLN2

protein_type:Enzyme

22:

protein_accession:HMDBP09212

name:Egl nine homolog 3

uniprot_id:Q9H6Z9

gene_name:EGLN3

protein_type:Enzyme

23:

protein_accession:HMDBP09213

name:Transmembrane prolyl 4-hydroxylase

uniprot_id:Q9NXG6

gene_name:P4HTM

protein_type:Enzyme

24:

protein_accession:HMDBP10688

name:Trans-L-3-hydroxyproline dehydratase

uniprot_id:Q96EM0

gene_name:L3HYPDH

protein_type:Enzyme

25:

protein_accession:HMDBP10690

name:Peptidyl-prolyl cis-trans isomerase F, mitochondrial

uniprot_id:P30405

gene_name:PPIF

protein_type:Enzyme

26:

protein_accession:HMDBP10691

name:Peptidyl-prolyl cis-trans isomerase A

uniprot_id:P62937

gene_name:PPIA

protein_type:Enzyme

27:

protein_accession:HMDBP10692

name:Peptidyl-prolyl cis-trans isomerase B

uniprot_id:P23284

gene_name:PPIB

protein_type:Enzyme

28:

protein_accession:HMDBP10693

name:Peptidyl-prolyl cis-trans isomerase G

uniprot_id:Q13427

gene_name:PPIG

protein_type:Enzyme

29:

protein_accession:HMDBP10694

name:Probable proline--tRNA ligase, mitochondrial

uniprot_id:Q7L3T8

gene_name:PARS2

protein_type:Enzyme

30:

protein_accession:HMDBP10695

name:Peptidyl-prolyl cis-trans isomerase H

uniprot_id:O43447

gene_name:PPIH

protein_type:Enzyme

蛋白质结合
1:

reference_text:Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762.

pubmed_id:19212411

2:

reference_text:Silwood CJ, Lynch E, Claxson AW, Grootveld MC: 1H and (13)C NMR spectroscopic analysis of human saliva. J Dent Res. 2002 Jun;81(6):422-7.

pubmed_id:12097436

3:

reference_text:Cynober LA: Plasma amino acid levels with a note on membrane transport: characteristics, regulation, and metabolic significance. Nutrition. 2002 Sep;18(9):761-6.

pubmed_id:12297216

4:

reference_text:Deng C, Shang C, Hu Y, Zhang X: Rapid diagnosis of phenylketonuria and other aminoacidemias by quantitative analysis of amino acids in neonatal blood spots by gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Jul 25;775(1):115-20.

pubmed_id:12101068

5:

reference_text:Azizi M, Junot C, Ezan E, Menard J: Angiotensin I-converting enzyme and metabolism of the haematological peptide N-acetyl-seryl-aspartyl-lysyl-proline. Clin Exp Pharmacol Physiol. 2001 Dec;28(12):1066-9.

pubmed_id:11903317

6:

reference_text:Roesel RA, Blankenship PR, Mobley EB, Coryell ME: Increased excretion of histidyl-L-proline diketopiperazine by infants receiving Pregestimil and Nutramigen formulas. Clin Chem. 1986 May;32(5):865-7.

pubmed_id:3698278

7:

reference_text:Chambers ST, Kunin CM: Osmoprotective activity for Escherichia coli in mammalian renal inner medulla and urine. Correlation of glycine and proline betaines and sorbitol with response to osmotic loads. J Clin Invest. 1987 Nov;80(5):1255-60.

pubmed_id:3316273

8:

reference_text:Azizi M, Ezan E, Reny JL, Wdzieczak-Bakala J, Gerineau V, Menard J: Renal and metabolic clearance of N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) during angiotensin-converting enzyme inhibition in humans. Hypertension. 1999 Mar;33(3):879-86.

pubmed_id:10082503

9:

reference_text:Hart W, van den Hamer CJ, van der Sluys Veer J: The use of hydroxy-DL-proline-2-(14)C in the investigation of hydroxyproline metabolism in normal subjects and in patients with renal insufficiency. Clin Nephrol. 1976 Sep;6(3):379-87.

pubmed_id:991465

10:

reference_text:Kanwar YS, Krakower CA, Manaligod JR, Justice P, Wong PW: Biochemical, morphological and hybrid studies in hyperprolinemic mice. Biomedicine. 1975 May;22(3):209-16.

pubmed_id:240452

11:

reference_text:Simila S: Hydroxyproline metabolism in type II hyperprolinaemia. Ann Clin Biochem. 1979 Jul;16(4):177-81.

pubmed_id:533224

12:

reference_text:Lu SH, Ohshima H, Fu HM, Tian Y, Li FM, Blettner M, Wahrendorf J, Bartsch H: Urinary excretion of N-nitrosamino acids and nitrate by inhabitants of high- and low-risk areas for esophageal cancer in Northern China: endogenous formation of nitrosoproline and its inhibition by vitamin C. Cancer Res. 1986 Mar;46(3):1485-91.

pubmed_id:3943105

13:

reference_text:Hausmann D: [Post-traumatic imbalances of plasma amino acids--interference factors or defense mechanisms? A study of protein metabolism in severe craniocerebral trauma]. Anasth Intensivther Notfallmed. 1988 Feb;23(1):14-21.

pubmed_id:3364629

14:

reference_text:Scriver CR, McInnes RR, Mohyuddin F: Role of epithelial architecture and intracellular metabolism in proline uptake and transtubular reclamation in PRO/re mouse kidney. Proc Natl Acad Sci U S A. 1975 Apr;72(4):1431-5.

pubmed_id:1055415

15:

reference_text:Boden G, Rezvani I, Owen OE: Effects of glucagon on plasma amino acids. J Clin Invest. 1984 Mar;73(3):785-93.

pubmed_id:6142902

16:

reference_text:Feldman JM, Plonk JW, Admiraal J, Sidbury JB: Plasma amino acids in patients with the carcinoid syndrome. Cancer. 1976 Nov;38(5):2127-31.

pubmed_id:136295

17:

reference_text:Humbertclaude V, Rivier F, Roubertie A, Echenne B, Bellet H, Vallat C, Morin D: Is hyperprolinemia type I actually a benign trait? Report of a case with severe neurologic involvement and vigabatrin intolerance. J Child Neurol. 2001 Aug;16(8):622-3.

pubmed_id:11510941

18:

reference_text:Nagata Y, Higashi M, Ishii Y, Sano H, Tanigawa M, Nagata K, Noguchi K, Urade M: The presence of high concentrations of free D-amino acids in human saliva. Life Sci. 2006 Mar 6;78(15):1677-81. Epub 2006 Feb 9.

pubmed_id:16480744

19:

reference_text:Nagata Y, Masui R, Akino T: The presence of free D-serine, D-alanine and D-proline in human plasma. Experientia. 1992 Oct 15;48(10):986-8.

pubmed_id:1426150

20:

reference_text:Nadler JV, Wang A, Hakim A: Toxicity of L-proline toward rat hippocampal neurons. Brain Res. 1988 Jul 19;456(1):168-72.

pubmed_id:3409032

21:

reference_text:Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043.

pubmed_id:32033212

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