版本
5.0
创建日期
2005-11-16 15:48:42 UTC
更新日期
2021-09-14 15:20:01 UTC
登录号
HMDB0000161
地位
quantified
二级访问
HMDB00161

名称
L-Alanine
描述
Alanine (Ala), also known as L-alanine is an alpha-amino acid. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). Amino acids are organic compounds that contain amino (–NH2) and carboxyl (–COOH) functional groups, along with a side chain (R group) specific to each amino acid. L-alanine is one of 20 proteinogenic amino acids, i.e., the amino acids used in the biosynthesis of proteins. Alanine is found in all organisms ranging from bacteria to plants to animals. It is classified as an aliphatic, non-polar amino acid. In humans, alanine is a non-essential amino acid that can be easily made in the body from either the conversion of pyruvate or the breakdown of the dipeptides carnosine and anserine. Alanine can be also synthesized from branched chain amino acids such as valine, leucine, and isoleucine. Alanine is produced by reductive amination of pyruvate through a two-step process. In the first step, alpha-ketoglutarate, ammonia and NADH are converted by the enzyme known glutamate dehydrogenase to glutamate, NAD+ and water. In the second step, the amino group of the newly-formed glutamate is transferred to pyruvate by an aminotransferase enzyme, regenerating the alpha-ketoglutarate, and converting the pyruvate to alanine. The net result is that pyruvate and ammonia are converted to alanine. In mammals, alanine plays a key role in glucose–alanine cycle between tissues and liver. In muscle and other tissues that degrade amino acids for fuel, amino groups are collected in the form of glutamate by transamination. Glutamate can then transfer its amino group to pyruvate, a product of muscle glycolysis, through the action of alanine aminotransferase, forming alanine and alpha-ketoglutarate. The alanine enters the bloodstream and is transported to the liver. The alanine aminotransferase reaction takes place in reverse in the liver, where the regenerated pyruvate is used in gluconeogenesis, forming glucose which returns to the muscles through the circulation system. Alanine is highly concentrated in muscle and is one of the most important amino acids released by muscle, functioning as a major energy source. Plasma alanine is often decreased when the BCAA (branched-chain amino acids) are deficient. This finding may relate to muscle metabolism. Alanine is highly concentrated in meat products and other high-protein foods like wheat germ and cottage cheese. Alanine is an important participant as well as a regulator of glucose metabolism. Alanine levels parallel blood sugar levels in both diabetes and hypoglycemia, and alanine is reduced in both severe hypoglycemia and the ketosis of diabetes. Alanine is an important amino acid for lymphocyte reproduction and immunity. Alanine therapy has helped dissolve kidney stones in experimental animals. Normal alanine metabolism, like that of other amino acids, is highly dependent upon enzymes that contain vitamin B6. Alanine, like GABA, taurine, and glycine, is an inhibitory neurotransmitter in the brain (http://www.dcnutrition.com/AminoAcids/).
同义词
1:(2S)-2-Aminopropanoic acid

2:(S)-2-Aminopropanoic acid

3:(S)-Alanine

4:A

5:Ala

6:ALANINE

7:L-2-Aminopropionic acid

8:L-Alanin

9:L-alpha-Alanine

10:(2S)-2-Aminopropanoate

11:(S)-2-Aminopropanoate

12:L-2-Aminopropionate

13:L-a-Alanine

14:L-Α-alanine

15:(S)-(+)-Alanine

16:(S)-2-Amino-propanoate

17:(S)-2-Amino-propanoic acid

18:2-Aminopropanoate

19:2-Aminopropanoic acid

20:2-Aminopropionate

21:2-Aminopropionic acid

22:2-Ammoniopropanoate

23:2-Ammoniopropanoic acid

24:a-Alanine

25:a-Aminopropionate

26:a-Aminopropionic acid

27:alpha-Alanine

28:alpha-Aminopropanoate

29:alpha-Aminopropanoic acid

30:alpha-Aminopropionate

31:alpha-Aminopropionic acid

32:L-(+)-Alanine

33:L-2-Aminopropanoate

34:L-2-Aminopropanoic acid

35:L-a-Aminopropionate

36:L-a-Aminopropionic acid

37:L-alpha-Aminopropionate

38:L-alpha-Aminopropionic acid

39:Abufène

40:Alanine doms-adrian brand

41:Alanine, L-isomer

42:Doms-adrian brand OF alanine

43:Doms adrian brand OF alanine

44:L-Isomer alanine

45:Alanine, L isomer

46:L Alanine

化学式
C3H7NO2
平均分子量
89.0932
等位分子量
89.047678473
化学名称
(2S)-2-aminopropanoic acid
传统名称
L-alanine
CAS 登记号
56-41-7
代谢物结构字符串
C[C@H](N)C(O)=O
inchi标识符
InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1
印记键
QNAYBMKLOCPYGJ-REOHCLBHSA-N
分类学
description: belongs to the class of organic compounds known as alanine and derivatives. Alanine and derivatives are compounds containing alanine or a derivative thereof resulting from reaction of alanine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.

description:Alanine and derivatives

kingdom:Organic compounds

super_class:Organic acids and derivatives

class:Carboxylic acids and derivatives

sub_class:Amino acids, peptides, and analogues

molecular_framework:Aliphatic acyclic compounds

1:Amino acids

2:Carbonyl compounds

3:Carboxylic acids

4:Hydrocarbon derivatives

5:L-alpha-amino acids

6:Monoalkylamines

7:Monocarboxylic acids and derivatives

8:Organic oxides

9:Organopnictogen compounds

10:Alanine or derivatives

11:Aliphatic acyclic compound

12:Alpha-amino acid

13:Amine

14:Amino acid

15:Carbonyl group

16:Carboxylic acid

17:Hydrocarbon derivative

18:L-alpha-amino acid

19:Monocarboxylic acid or derivatives

20:Organic nitrogen compound

21:Organic oxide

22:Organic oxygen compound

23:Organonitrogen compound

24:Organooxygen compound

25:Organopnictogen compound

26:Primary aliphatic amine

27:Primary amine

28:Common amino acids

29:L-alpha-amino acid

30:alanine

31:proteinogenic amino acid

32:pyruvate family amino acid

本体论
term:Physiological effect

definition:The effect on an organism physiology, resulting from its exposure to a chemical.

parent_id:

level:1

type:parent

term:Health effect

definition:A health condition or observation associated with a stimuli or with a biological activity of a chemical.

parent_id:7693

*level:2

type:parent

term:Health condition

definition:A health effect that consists on short or long-term disease, condition, disorder, syndrome or constant abnormality.

parent_id:7694

**level:3

type:parent

term:Epilepsy

definition:A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions. (do).

parent_id:7695

***level:4

type:child

synonym:Epileptic spasms

term:Schizophrenia

definition:A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness. (do).

parent_id:7695

***level:4

type:child

term:Paraquat poisoning

definition:

parent_id:7695

***level:4

type:child

term:Dengue fever

definition:

parent_id:7695

***level:4

type:child

synonym:Dhf

synonym:Dengue hemorrhagic fever

term:Cancer

definition:A group of disorders characterized by the presense of malignant neoplasm.

parent_id:7695

***level:4

type:parent

term:Infections and infestations

definition:Any disorder resulting from the presence and activity of a microbial, viral, or parasitic agent. it can be transmitted by direct or indirect contact. (nci).

parent_id:7695

***level:4

type:parent

term:Cardiac disorders

definition:Any disorder that affects the heart.

parent_id:7695

***level:4

type:parent

term:Disposition

definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.

parent_id:

level:1

type:parent

term:Route of exposure

definition:A mean by which a chemical agent comes in contact with an organism, either under intended or unintended circumstances.

parent_id:7724

*level:2

type:parent

term:Enteral

definition:Chemical exposure via the alimentary canal (mouth to anus).

parent_id:7743

**level:3

type:parent

term:Ingestion

definition:Chemical exposure facilitated by entry through the mouth.

parent_id:7744

***level:4

type:child

synonym:Digestion

term:Source

definition:Natural or synthetic origin of a chemical.

parent_id:7724

*level:2

type:parent

term:Endogenous

definition:

parent_id:7735

**level:3

type:child

term:Food

definition:

parent_id:7735

**level:3

type:child

term:Synthetic

definition:A man-made product or sample in which a chemical can be found.

parent_id:7735

**level:3

type:parent

term:Personal care product

definition:

parent_id:7742

***level:4

type:child

synonym:Pcp

synonym:Toiletries

synonym:Toiletry

synonym:Personal hygiene

synonym:Beautification product

term:Biological

definition:A living organism (species or a higher taxonomy rank), in which a chemical can be found.

parent_id:7735

**level:3

type:parent

term:Animal

definition:A living organism belonging to the kingdom animalia. it feeds on organic matter, typically having specialized sense organs and nervous system and able to respond rapidly to stimuli.

parent_id:7736

***level:4

type:child

synonym:Fauna

term:Plant

definition:A living organism belonging to the kingdom plantea. typically, it grows in a permanent site, absorbs water and inorganic substances through its roots, and synthesizes nutrients in its leaves by photosynthesis using the green pigment chlorophyll. examples incude trees, shrubs, herbs, grasses, ferns, and mosses.

parent_id:7736

***level:4

type:parent

synonym:Flora

term:Biological location

definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.

parent_id:7724

*level:2

type:parent

term:Tissue and substructures

definition:An anatomical organizational level including multiple cells yet not comprising a complete organ .

parent_id:7725

**level:3

type:parent

term:All tissues

definition:All tissues in the body of the organism.

parent_id:7729

***level:4

type:child

term:Placenta

definition:An organ present in some vertebrates during embryonic gestation that surrounds the fetus and provides it with nutrients and oxygen, facilitates gas and waste exchange between the fetus and mother, and provides parasitic cloaking from the mother's immune system by excretion of neurokinin b. (nci).

parent_id:7729

***level:4

type:child

term:Organ and components

definition:An anatomical organizational level including multiple tissues or substructures, which enables a common biological function.

parent_id:7725

**level:3

type:parent

term:Prostate

definition:The male reproductive accessory gland that produces prostatic fluid and is located adjacent to or around the urethra distal to the urinary bladder in mammals. (nci).

parent_id:7727

***level:4

type:child

synonym:Prostate gland

term:Biofluid and excreta

definition:A liquid, semi-solid or solid material originating in the body.

parent_id:7725

**level:3

type:parent

term:Urine

definition:Excretion in liquid state processed by the kidney.

parent_id:7731

***level:4

type:child

term:Saliva

definition:The watery fluid in the mouth made by the salivary glands. saliva moistens food to help digestion and it helps protect the mouth against infections. (nci).

parent_id:7731

***level:4

type:child

term:Feces

definition:The material discharged from the bowel during defecation. It consists of undigested food, intestinal mucus, epithelial cells, and bacteria.

parent_id:7731

***level:4

type:child

synonym:Fecal

synonym:Stool

synonym:Faecal

synonym:Faeces

term:Blood

definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.

parent_id:7731

***level:4

type:child

term:Breast milk

definition:Portion of secreted substance produced by the mammary gland.

parent_id:7731

***level:4

type:child

term:Sweat

definition:Secretion produced by a sweat gland.

parent_id:7731

***level:4

type:child

term:Cerebrospinal fluid

definition:The fluid that is contained within the brain ventricles, the subarachnoid space and the central canal of the spinal cord. (nci).

parent_id:7731

***level:4

type:child

synonym:Csf

term:Subcellular

definition:An anatomical organizational level including a component within a biological cell .

parent_id:7725

**level:3

type:parent

term:Cytoplasm

definition:The portion of the cell contained within the plasma membrane but excluding the nucleus.

parent_id:7730

***level:4

type:child

synonym:Cytoplasma

term:Mitochondria

definition:

parent_id:7730

***level:4

type:child

term:Lysosome

definition:В A sac-like compartment inside a cell that has enzymes that can break down cellular components that need to be destroyed. (NCI).

parent_id:7730

***level:4

type:child

term:Peroxisome

definition:A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. (Gene Ontology).

parent_id:7730

***level:4

type:child

synonym:Peroxisome vesicle

synonym:Peroxisomal

term:Cell and elements

definition:An anatomical organizational level comprising of a single cell (or a fragment in some exceptions). a cell is defined by its type or function. it is the smallest unit of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid.

parent_id:7725

**level:3

type:parent

term:Extracellular

definition:The space external to the outermost structure of a cell.

parent_id:7732

***level:4

type:child

synonym:Extracellular region

term:Process

definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.

parent_id:

level:1

type:parent

term:Naturally occurring process

definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.

parent_id:7659

*level:2

type:parent

term:Biological process

definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.

parent_id:7660

**level:3

type:parent

term:Biochemical pathway

definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.

parent_id:7661

***level:4

type:parent

term:Role

definition:The purpose or function assumed by a chemical, either naturally or as intended by humans .

parent_id:

level:1

type:parent

term:Industrial application

definition:The assumed function of a chemical utilized by human.

parent_id:7671

*level:2

type:parent

term:Food and nutrition

definition:A chemical purpose related to manufacturing of food and nutrition products.

parent_id:7678

**level:3

type:child

term:Personal care products

definition:Cosmetics and personal hygene products in which a chemical was incorportaed during the manufacturing process.

parent_id:7678

**level:3

type:child

状态
Solid
实验性质
1:

kind:water_solubility

value:204 mg/mL

source:Human Metabolome Project

2:

kind:logp

value:-2.85

source:SANGSTER (1994)

3:

kind:melting_point

value:300 °C

source:

预测性质
1:

kind:logp

value:-3.05

source:ALOGPS

2:

kind:logs

value:0.70

source:ALOGPS

3:

kind:solubility

value:447 g/L

source:ALOGPS

4:

kind:logp

value:-2.8

source:ChemAxon

5:

kind:pka_strongest_acidic

value:2.47

source:ChemAxon

6:

kind:pka_strongest_basic

value:9.48

source:ChemAxon

7:

kind:iupac

value:(2S)-2-aminopropanoic acid

source:ChemAxon

8:

kind:average_mass

value:89.0932

source:ChemAxon

9:

kind:mono_mass

value:89.047678473

source:ChemAxon

10:

kind:smiles

value:C[C@H](N)C(O)=O

source:ChemAxon

11:

kind:formula

value:C3H7NO2

source:ChemAxon

12:

kind:inchi

value:InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1

source:ChemAxon

13:

kind:inchikey

value:QNAYBMKLOCPYGJ-REOHCLBHSA-N

source:ChemAxon

14:

kind:polar_surface_area

value:63.32

source:ChemAxon

15:

kind:refractivity

value:20.5

source:ChemAxon

16:

kind:polarizability

value:8.49

source:ChemAxon

17:

kind:rotatable_bond_count

value:1

source:ChemAxon

18:

kind:acceptor_count

value:3

source:ChemAxon

19:

kind:donor_count

value:2

source:ChemAxon

20:

kind:physiological_charge

value:0

source:ChemAxon

21:

kind:formal_charge

value:0

source:ChemAxon

22:

kind:number_of_rings

value:0

source:ChemAxon

23:

kind:bioavailability

value:Yes

source:ChemAxon

24:

kind:rule_of_five

value:Yes

source:ChemAxon

25:

kind:ghose_filter

value:No

source:ChemAxon

26:

kind:veber_rule

value:No

source:ChemAxon

27:

kind:mddr_like_rule

value:No

source:ChemAxon

1:

type:Specdb::CMs

spectrum_id:392

2:

type:Specdb::CMs

spectrum_id:393

3:

type:Specdb::CMs

spectrum_id:394

4:

type:Specdb::CMs

spectrum_id:914

5:

type:Specdb::CMs

spectrum_id:2826

6:

type:Specdb::CMs

spectrum_id:28767

7:

type:Specdb::CMs

spectrum_id:30040

8:

type:Specdb::CMs

spectrum_id:30043

9:

type:Specdb::CMs

spectrum_id:30364

10:

type:Specdb::CMs

spectrum_id:30475

11:

type:Specdb::CMs

spectrum_id:30723

12:

type:Specdb::CMs

spectrum_id:30788

13:

type:Specdb::CMs

spectrum_id:31034

14:

type:Specdb::CMs

spectrum_id:37330

15:

type:Specdb::CMs

spectrum_id:156837

16:

type:Specdb::MsMs

spectrum_id:251

17:

type:Specdb::MsMs

spectrum_id:252

18:

type:Specdb::MsMs

spectrum_id:253

19:

type:Specdb::MsMs

spectrum_id:3220

20:

type:Specdb::MsMs

spectrum_id:3221

21:

type:Specdb::MsMs

spectrum_id:3222

22:

type:Specdb::MsMs

spectrum_id:3223

23:

type:Specdb::MsMs

spectrum_id:3224

24:

type:Specdb::MsMs

spectrum_id:3225

25:

type:Specdb::MsMs

spectrum_id:3226

26:

type:Specdb::MsMs

spectrum_id:3227

27:

type:Specdb::MsMs

spectrum_id:3228

28:

type:Specdb::MsMs

spectrum_id:3232

29:

type:Specdb::MsMs

spectrum_id:178938

30:

type:Specdb::MsMs

spectrum_id:178939

31:

type:Specdb::MsMs

spectrum_id:178940

32:

type:Specdb::MsMs

spectrum_id:181263

33:

type:Specdb::MsMs

spectrum_id:181264

34:

type:Specdb::MsMs

spectrum_id:181265

35:

type:Specdb::MsMs

spectrum_id:437096

36:

type:Specdb::MsMs

spectrum_id:437097

37:

type:Specdb::MsMs

spectrum_id:437098

38:

type:Specdb::MsMs

spectrum_id:445526

39:

type:Specdb::MsMs

spectrum_id:445527

40:

type:Specdb::MsMs

spectrum_id:445528

41:

type:Specdb::NmrTwoD

spectrum_id:976

42:

type:Specdb::NmrTwoD

spectrum_id:1178

43:

type:Specdb::NmrOneD

spectrum_id:1120

44:

type:Specdb::NmrOneD

spectrum_id:1178

45:

type:Specdb::NmrOneD

spectrum_id:142610

46:

type:Specdb::NmrOneD

spectrum_id:142611

47:

type:Specdb::NmrOneD

spectrum_id:142612

48:

type:Specdb::NmrOneD

spectrum_id:142613

49:

type:Specdb::NmrOneD

spectrum_id:142614

50:

type:Specdb::NmrOneD

spectrum_id:142615

51:

type:Specdb::NmrOneD

spectrum_id:142616

52:

type:Specdb::NmrOneD

spectrum_id:142617

53:

type:Specdb::NmrOneD

spectrum_id:142618

54:

type:Specdb::NmrOneD

spectrum_id:142619

55:

type:Specdb::NmrOneD

spectrum_id:142620

56:

type:Specdb::NmrOneD

spectrum_id:142621

57:

type:Specdb::NmrOneD

spectrum_id:142622

58:

type:Specdb::NmrOneD

spectrum_id:142623

59:

type:Specdb::NmrOneD

spectrum_id:142624

60:

type:Specdb::NmrOneD

spectrum_id:142625

61:

type:Specdb::NmrOneD

spectrum_id:142626

62:

type:Specdb::NmrOneD

spectrum_id:142627

63:

type:Specdb::NmrOneD

spectrum_id:142628

64:

type:Specdb::NmrOneD

spectrum_id:142629

光谱
生物学性质
1:

cellular:(1):Cytoplasm

cellular:(2):Extracellular

cellular:(3):Lysosome

cellular:(4):Mitochondria

cellular:(5):Peroxisome

2:

biospecimen:(1):Blood

biospecimen:(2):Breast Milk

biospecimen:(3):Cerebrospinal Fluid (CSF)

biospecimen:(4):Feces

biospecimen:(5):Saliva

biospecimen:(6):Sweat

biospecimen:(7):Urine

3:

tissue:(1):All Tissues

tissue:(2):Placenta

tissue:(3):Prostate

4:

[1]:

name:2-Hydroxyglutric Aciduria (D And L Form)

smpdb_id:SMP00136

kegg_map_id:

[2]:

name:3-Phosphoglycerate dehydrogenase deficiency

smpdb_id:SMP00721

kegg_map_id:

[3]:

name:4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency

smpdb_id:SMP00243

kegg_map_id:

[4]:

name:5-oxoprolinase deficiency

smpdb_id:SMP00500

kegg_map_id:

[5]:

name:Alanine, aspartate and glutamate metabolism

smpdb_id:

kegg_map_id:map00250

[6]:

name:Amikacin Action Pathway

smpdb_id:SMP00253

kegg_map_id:

[7]:

name:Arbekacin Action Pathway

smpdb_id:SMP00713

kegg_map_id:

[8]:

name:Argininemia

smpdb_id:SMP00357

kegg_map_id:

[9]:

name:Argininosuccinic Aciduria

smpdb_id:SMP00003

kegg_map_id:

[10]:

name:Azithromycin Action Pathway

smpdb_id:SMP00247

kegg_map_id:

[11]:

name:Carbamoyl Phosphate Synthetase Deficiency

smpdb_id:SMP00002

kegg_map_id:

[12]:

name:Chloramphenicol Action Pathway

smpdb_id:SMP00729

kegg_map_id:

[13]:

name:Citrullinemia Type I

smpdb_id:SMP00001

kegg_map_id:

[14]:

name:Clarithromycin Action Pathway

smpdb_id:SMP00248

kegg_map_id:

[15]:

name:Clindamycin Action Pathway

smpdb_id:SMP00249

kegg_map_id:

[16]:

name:Clomocycline Action Pathway

smpdb_id:SMP00262

kegg_map_id:

[17]:

name:Demeclocycline Action Pathway

smpdb_id:SMP00290

kegg_map_id:

[18]:

name:Dihydropyrimidine Dehydrogenase Deficiency (DHPD)

smpdb_id:SMP00179

kegg_map_id:

[19]:

name:Dimethylglycine Dehydrogenase Deficiency

smpdb_id:SMP00242

kegg_map_id:

[20]:

name:Dimethylglycine Dehydrogenase Deficiency

smpdb_id:SMP00484

kegg_map_id:

[21]:

name:Doxycycline Action Pathway

smpdb_id:SMP00291

kegg_map_id:

[22]:

name:Erythromycin Action Pathway

smpdb_id:SMP00250

kegg_map_id:

[23]:

name:Gamma-glutamyl-transpeptidase deficiency

smpdb_id:SMP00501

kegg_map_id:

[24]:

name:Gamma-Glutamyltransferase Deficiency

smpdb_id:SMP00183

kegg_map_id:

[25]:

name:Gentamicin Action Pathway

smpdb_id:SMP00254

kegg_map_id:

[26]:

name:Glucose-Alanine Cycle

smpdb_id:SMP00127

kegg_map_id:

[27]:

name:Glutamate Metabolism

smpdb_id:SMP00072

kegg_map_id:map00250

[28]:

name:Glutaminolysis and Cancer

smpdb_id:SMP02298

kegg_map_id:

[29]:

name:Glutathione metabolism

smpdb_id:

kegg_map_id:map00480

[30]:

name:Glutathione Synthetase Deficiency

smpdb_id:SMP00337

kegg_map_id:

[31]:

name:Glycine, serine and threonine metabolism

smpdb_id:

kegg_map_id:map00260

[32]:

name:Homocarnosinosis

smpdb_id:SMP00385

kegg_map_id:

[33]:

name:Hyperglycinemia, non-ketotic

smpdb_id:SMP00485

kegg_map_id:

[34]:

name:Hyperinsulinism-Hyperammonemia Syndrome

smpdb_id:SMP00339

kegg_map_id:

[35]:

name:Josamycin Action Pathway

smpdb_id:SMP00731

kegg_map_id:

[36]:

name:Kanamycin Action Pathway

smpdb_id:SMP00255

kegg_map_id:

[37]:

name:Lactic Acidemia

smpdb_id:SMP00313

kegg_map_id:

[38]:

name:Lincomycin Action Pathway

smpdb_id:SMP00728

kegg_map_id:

[39]:

name:Lymecycline Action Pathway

smpdb_id:SMP00295

kegg_map_id:

[40]:

name:Methacycline Action Pathway

smpdb_id:SMP00727

kegg_map_id:

[41]:

name:Minocycline Action Pathway

smpdb_id:SMP00292

kegg_map_id:

[42]:

name:Neomycin Action Pathway

smpdb_id:SMP00256

kegg_map_id:

[43]:

name:Netilmicin Action Pathway

smpdb_id:SMP00257

kegg_map_id:

[44]:

name:Non Ketotic Hyperglycinemia

smpdb_id:SMP00223

kegg_map_id:

[45]:

name:Ornithine Transcarbamylase Deficiency (OTC Deficiency)

smpdb_id:SMP00205

kegg_map_id:

[46]:

name:Oxytetracycline Action Pathway

smpdb_id:SMP00293

kegg_map_id:

[47]:

name:Paromomycin Action Pathway

smpdb_id:SMP00714

kegg_map_id:

[48]:

name:Primary Hyperoxaluria Type I

smpdb_id:SMP00352

kegg_map_id:

[49]:

name:Pyruvate Carboxylase Deficiency

smpdb_id:SMP00350

kegg_map_id:

[50]:

name:Rolitetracycline Action Pathway

smpdb_id:SMP00726

kegg_map_id:

[51]:

name:Roxithromycin Action Pathway

smpdb_id:SMP00251

kegg_map_id:

[52]:

name:Sarcosinemia

smpdb_id:SMP00244

kegg_map_id:

[53]:

name:Selenocompound metabolism

smpdb_id:

kegg_map_id:map00450

[54]:

name:Spectinomycin Action Pathway

smpdb_id:SMP00258

kegg_map_id:

[55]:

name:Streptomycin Action Pathway

smpdb_id:SMP00259

kegg_map_id:

[56]:

name:Succinic semialdehyde dehydrogenase deficiency

smpdb_id:SMP00567

kegg_map_id:

[57]:

name:Telithromycin Action Pathway

smpdb_id:SMP00252

kegg_map_id:

[58]:

name:Tetracycline Action Pathway

smpdb_id:SMP00294

kegg_map_id:

[59]:

name:Tigecycline Action Pathway

smpdb_id:SMP00712

kegg_map_id:

[60]:

name:Tobramycin Action Pathway

smpdb_id:SMP00711

kegg_map_id:

[61]:

name:Transcription/Translation

smpdb_id:SMP00019

kegg_map_id:

[62]:

name:Troleandomycin Action Pathway

smpdb_id:SMP00730

kegg_map_id:

[63]:

name:Tryptophan metabolism

smpdb_id:

kegg_map_id:map00380

[64]:

name:Urea Cycle

smpdb_id:SMP00059

kegg_map_id:map00330

正常浓度
1:

biospecimen:Blood

concentration_value:97-455

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

2:

biospecimen:Blood

concentration_value:134-416

concentration_units:uM

subject_age:Infant (1 - 3 months old)

subject_sex:Both

subject_condition:Normal

3:

biospecimen:Blood

concentration_value:148-475

concentration_units:uM

subject_age:Children (3 months - 6 years old)

subject_sex:Both

subject_condition:Normal

4:

biospecimen:Blood

concentration_value:193-545

concentration_units:uM

subject_age:Children (6 - 18 years old)

subject_sex:Both

subject_condition:Normal

5:

biospecimen:Blood

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

6:

biospecimen:Blood

concentration_value:134-502

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

7:

biospecimen:Blood

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

8:

biospecimen:Blood

concentration_value:333.0 (259.0-407.0)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

9:

biospecimen:Blood

concentration_value:<414

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Not Specified

subject_condition:Normal

10:

biospecimen:Blood

concentration_value:174-375

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

11:

biospecimen:Blood

concentration_value:240-600

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

12:

biospecimen:Blood

concentration_value:320 +/- 87

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

13:

biospecimen:Blood

concentration_value:140 - 460

concentration_units:uM

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

14:

biospecimen:Blood

concentration_value:254 +/- 78

concentration_units:uM

subject_age:Children (1 - 13 years old)

subject_sex:Female

subject_condition:Normal

15:

biospecimen:Blood

concentration_value:255 +/- 78

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

16:

biospecimen:Blood

concentration_value:375.0 +/- 50.0

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Not Specified

subject_condition:Normal

17:

biospecimen:Blood

concentration_value:369.0 +/- 88.0

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Female

subject_condition:Normal

18:

biospecimen:Blood

concentration_value:444.61(116.67)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

19:

biospecimen:Blood

concentration_value:448.89(115.71)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

20:

biospecimen:Blood

concentration_value:200.0-580.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

21:

biospecimen:Blood

concentration_value:319.4 +/- 71.7

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

22:

biospecimen:Blood

concentration_value:465.7(395.5-592.1)

concentration_units:uM

subject_age:Children (1-13 uears old)

subject_sex:Both

subject_condition:Normal

23:

biospecimen:Blood

concentration_value:<500

concentration_units:uM

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

24:

biospecimen:Blood

concentration_value:427.2 +/- 84.4

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

25:

biospecimen:Blood

concentration_value:585.0 +/- 22.0

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

26:

biospecimen:Breast Milk

concentration_value:231 +/- 67.2

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

27:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:46 +/- 27

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

28:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:37.8 +/- 6.8

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

29:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:30.8 +/- 8.7

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

30:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:26.3 +/- 7.4

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

31:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:6-47

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

32:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:23.0-39.5

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

33:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:28.5-38.0

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Not Specified

subject_condition:Normal

34:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:27.0 (10.0-44.0)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

35:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:4.23 +/- 0.64

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

36:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:11-53.5

concentration_units:uM

subject_age:Children (0 - 10 years old)

subject_sex:Both

subject_condition:Normal

37:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:10.5-49.5

concentration_units:uM

subject_age:Adolescent (>11 years old)

subject_sex:Both

subject_condition:Normal

38:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:23.2 +/- 5.1

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

39:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Children (1-13 years old)

subject_sex:Both

subject_condition:Normal

40:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

41:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

42:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Not Specified

subject_sex:Both

subject_condition:Normal

43:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

44:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

45:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

46:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

47:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

48:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

49:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

50:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Children (6 - 18 years old)

subject_sex:Both

subject_condition:Normal

51:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Children (6 - 18 years old)

subject_sex:Not Specified

subject_condition:Normal

52:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

53:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

54:

biospecimen:Feces

concentration_value:137.272 +/- 93.0486

concentration_units:nmol/g wet feces

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

55:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

56:

biospecimen:Feces

concentration_value:4451.518 +/- 2351.470

concentration_units:nmol/g wet feces

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

57:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

58:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

59:

biospecimen:Feces

concentration_value:2660 +/- 1870

concentration_units:nmol/g wet feces

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

60:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

61:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

62:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

63:

biospecimen:Feces

concentration_value:600 +/- 470

concentration_units:nmol/g wet feces

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

64:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

65:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

66:

biospecimen:Feces

concentration_value:11283

concentration_units:nmol/g wet feces

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

67:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Not Specified

subject_sex:Not Specified

subject_condition:Normal

68:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

69:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

70:

biospecimen:Feces

concentration_value:8791

concentration_units:nmol/g wet feces

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

71:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

72:

biospecimen:Feces

concentration_value:12245

concentration_units:nmol/g wet feces

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

73:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

74:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

75:

biospecimen:Saliva

concentration_value:17.0 +/- 9.27

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

76:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

77:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

78:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

79:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

80:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

81:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

82:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

83:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

84:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

85:

biospecimen:Saliva

concentration_value:18.8 +/- 20.4

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

86:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

87:

biospecimen:Saliva

concentration_value:17.4 +/- 4.9

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

88:

biospecimen:Saliva

concentration_value:14.0 +/- 3.1

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

89:

biospecimen:Saliva

concentration_value:1-263

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:normal

90:

biospecimen:Saliva

concentration_value:1-65

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:normal

91:

biospecimen:Saliva

concentration_value:20.7 +/- 6.4

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

92:

biospecimen:Saliva

concentration_value:>10

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

93:

biospecimen:Saliva

concentration_value:145.27 +/- 108.41

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

94:

biospecimen:Saliva

concentration_value:19.2 +/- 5.6

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

95:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

96:

biospecimen:Saliva

concentration_value:57.54 +/- 42.59

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

97:

biospecimen:Saliva

concentration_value:30.5 +/- 39.6

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

98:

biospecimen:Saliva

concentration_value:26 (7-137)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

99:

biospecimen:Saliva

concentration_value:23 (4-116)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

100:

biospecimen:Saliva

concentration_value:27 (<1-96)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

101:

biospecimen:Saliva

concentration_value:25 (<1-81)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

102:

biospecimen:Sweat

concentration_value:270-590

concentration_units:uM

subject_age:Adult (60 years old)

subject_sex:Male

subject_condition:Normal

103:

biospecimen:Sweat

concentration_value:180

concentration_units:uM

subject_age:Adult (40 years old)

subject_sex:Male

subject_condition:Normal

104:

biospecimen:Sweat

concentration_value:

concentration_units:

subject_age:Adult

subject_sex:Both

subject_condition:Normal

105:

biospecimen:Urine

concentration_value:4.98-92.078

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

106:

biospecimen:Urine

concentration_value:39.0

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

107:

biospecimen:Urine

concentration_value:15.7 +/- 14.7

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

108:

biospecimen:Urine

concentration_value:5.77-78.73

concentration_units:umol/mmol creatinine

subject_age:Adolescent (13-18 years old)

subject_sex:Not Specified

subject_condition:Normal

109:

biospecimen:Urine

concentration_value:9-19

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

110:

biospecimen:Urine

concentration_value:16.84-56.15

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

111:

biospecimen:Urine

concentration_value:6.33-58.60

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

112:

biospecimen:Urine

concentration_value:18.72

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

113:

biospecimen:Urine

concentration_value:152.67 (69.78-235.56)

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

114:

biospecimen:Urine

concentration_value:12.3 +/- 5.6

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Male

subject_condition:Normal

115:

biospecimen:Urine

concentration_value:22.0 +/- 11.0

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

116:

biospecimen:Urine

concentration_value:22.0 +/- 10.0

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

117:

biospecimen:Urine

concentration_value:10.52-340.09

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Not Specified

subject_condition:Normal

118:

biospecimen:Urine

concentration_value:21.8 (7.1-43.1)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

119:

biospecimen:Urine

concentration_value:172.585-558.364

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

120:

biospecimen:Urine

concentration_value:65.012 +/- 27.635

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

121:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

122:

biospecimen:Urine

concentration_value:33.5 +/- 14.0

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

123:

biospecimen:Urine

concentration_value:34.3 +/- 11.5

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

124:

biospecimen:Urine

concentration_value:8.1 +/- 2.0

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

125:

biospecimen:Urine

concentration_value:8.5 +/- 2.8

concentration_units:umol/mmol creatinine

subject_age:Infant (6 months - <1 year old)

subject_sex:Both

subject_condition:Normal

126:

biospecimen:Urine

concentration_value:8.8 +/- 2.2

concentration_units:umol/mmol creatinine

subject_age:Infant (1 - 6 months old)

subject_sex:Both

subject_condition:Normal

127:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

128:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

129:

biospecimen:Urine

concentration_value:19.46 +/- 5.32

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

130:

biospecimen:Urine

concentration_value:11.42-169.68

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

131:

biospecimen:Urine

concentration_value:10-20

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

132:

biospecimen:Urine

concentration_value:21.7 (7.2-47.4)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

133:

biospecimen:Urine

concentration_value:85.59 - 284.69

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

134:

biospecimen:Urine

concentration_value:81.97 - 239.91

concentration_units:umol/mmol creatinine

subject_age:Infant (1 - 6 months old)

subject_sex:Both

subject_condition:Normal

135:

biospecimen:Urine

concentration_value:39.57 - 187.91

concentration_units:umol/mmol creatinine

subject_age:Infant (6 months - <1 year old)

subject_sex:Both

subject_condition:Normal

136:

biospecimen:Urine

concentration_value:45.45 - 150.26

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 2 years old)

subject_sex:Both

subject_condition:Normal

137:

biospecimen:Urine

concentration_value:35.95 - 132.73

concentration_units:umol/mmol creatinine

subject_age:Children (2 - 4 years old)

subject_sex:Both

subject_condition:Normal

138:

biospecimen:Urine

concentration_value:16.96 - 105.48

concentration_units:umol/mmol creatinine

subject_age:Children (4 - 13 years old)

subject_sex:Both

subject_condition:Normal

139:

biospecimen:Urine

concentration_value:16.05 - 77.33

concentration_units:umol/mmol creatinine

subject_age:Adolescent (13 - 21 years old)

subject_sex:Both

subject_condition:Normal

140:

biospecimen:Urine

concentration_value:16.05 - 77.33

concentration_units:umol/mmol creatinine

subject_age:Adult (>21 years old)

subject_sex:Both

subject_condition:Normal

141:

biospecimen:Urine

concentration_value:73.1768 +/- 22.3291

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

142:

biospecimen:Urine

concentration_value:40.8

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

143:

biospecimen:Urine

concentration_value:68-334

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

144:

biospecimen:Urine

concentration_value:14-133

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

145:

biospecimen:Urine

concentration_value:7.24-146.94

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

146:

biospecimen:Urine

concentration_value:41-130

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Not Specified

subject_condition:Normal

147:

biospecimen:Urine

concentration_value:260.04 +/- 90.45

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

148:

biospecimen:Urine

concentration_value:395.71 +/- 146.98

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

149:

biospecimen:Urine

concentration_value:610.52 +/- 226.12

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

150:

biospecimen:Urine

concentration_value:113.35 +/- 69.81

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

151:

biospecimen:Urine

concentration_value:13.2

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

152:

biospecimen:Urine

concentration_value:27-350

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

153:

biospecimen:Urine

concentration_value:32.25-147.8

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

154:

biospecimen:Urine

concentration_value:70.70 +/- 24.41

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Female

subject_condition:Normal

155:

biospecimen:Urine

concentration_value:79.85 +/- 30.57

concentration_units:umol/mmol creatinine

subject_age:Newborn (0-30 days old)

subject_sex:Male

subject_condition:Normal

156:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

异常浓度
1:

biospecimen:Blood

concentration_value:340 +/- 126.2

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Heart Transplant

2:

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Schizophrenia

3:

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

4:

biospecimen:Blood

concentration_value:293.4 +/- 83.44

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy with fetuses with trisomy 18

5:

biospecimen:Blood

concentration_value:258.62 +/- 85.38

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

6:

biospecimen:Blood

concentration_value:263.8 (51.5)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Early preeclampsia

7:

biospecimen:Blood

concentration_value:332.1 (184.2)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

8:

biospecimen:Blood

concentration_value:455 (221-1086)

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Male

patient_information:Lipoyltransferase 1 Deficiency

9:

biospecimen:Blood

concentration_value:676 +/- 386 (156-1503)

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Female

patient_information:Pearson Syndrome

10:

biospecimen:Blood

concentration_value:1088

concentration_units:uM

patient_age:Newborn (0-30 days old)

patient_sex:Male

patient_information:Coenzyme Q10 deficiency, primary, 5

11:

biospecimen:Blood

concentration_value:274.0 (250.0-298.0)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Dengue fever

12:

biospecimen:Blood

concentration_value:958

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:

patient_information:Pyruvate carboxylase deficiency

13:

biospecimen:Blood

concentration_value:296.0 (277.0-316.0)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Epilepsy

14:

biospecimen:Blood

concentration_value:233-331

concentration_units:uM

patient_age:Newborn (0-30 days old)

patient_sex:Female

patient_information:Mitochondrial pyruvate carrier deficiency

15:

biospecimen:Blood

concentration_value:658-1082

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Pearson Syndrome

16:

biospecimen:Blood

concentration_value:1559

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Female

patient_information:Pearson Syndrome

17:

biospecimen:Blood

concentration_value:707.125

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Male

patient_information:Dihydrolipoamide Dehydrogenase Deficiency

18:

biospecimen:Blood

concentration_value:298

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:

patient_information:Pyruvate carboxylase deficiency

19:

biospecimen:Blood

concentration_value:392 +/- 111

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Schizophrenia

20:

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:colorectal cancer

21:

biospecimen:Blood

concentration_value:284.62 (65.96)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy with fetus having congenital heart defect

22:

biospecimen:Blood

concentration_value:520

concentration_units:uM

patient_age:Children (1 - 13 years old)

patient_sex:Female

patient_information:Leigh's syndrome

23:

biospecimen:Blood

concentration_value:267.32 (53.39)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

24:

biospecimen:Blood

concentration_value:185-1264

concentration_units:uM

patient_age:Newborn (0-30 days old)

patient_sex:Male

patient_information:N-Acetylglutamate synthetase deficiency

25:

biospecimen:Blood

concentration_value:249 +/- 94

concentration_units:uM

patient_age:Children (1 - 13 years old)

patient_sex:Male

patient_information:Histidinuria

26:

biospecimen:Blood

concentration_value:261-432

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Male

patient_information:N-Acetylglutamate synthetase deficiency

27:

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

28:

biospecimen:Blood

concentration_value:31 +/- 8.7

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Male

patient_information:Glucagon deficiency

29:

biospecimen:Blood

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Pancreatic cancer

30:

biospecimen:Blood

concentration_value:492.6(418.6-580.2)

concentration_units:uM

patient_age:Children (1-13 uears old)

patient_sex:Both

patient_information:Environmental enteric dysfunction

31:

biospecimen:Blood

concentration_value:366.8 (204.8)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Late-onset preeclampsia

32:

biospecimen:Blood

concentration_value:496.62(101.29)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Heart failure with preserved ejection fraction

33:

biospecimen:Blood

concentration_value:323.8 (151.2)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

34:

biospecimen:Blood

concentration_value:1000

concentration_units:uM

patient_age:Infant (0-1 year old)

patient_sex:Male

patient_information:Pyruvate dehydrogenase phosphatase deficiency

35:

biospecimen:Blood

concentration_value:589.0 +/- 15.0

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Heart failure

36:

biospecimen:Blood

concentration_value:247.2 (89.1)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Down syndrome pregnancy

37:

biospecimen:Blood

concentration_value:231.9 (87.3)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Pregnancy

38:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:46.1 +/- 13.5

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Not Specified

patient_information:Leukemia

39:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:34.8 +/- 7.8

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Not Specified

patient_information:Leukemia

40:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:52

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Male

patient_information:Lipoyltransferase 1 Deficiency

41:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:48.6

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Female

patient_information:Epilepsy, early-onset, vitamin B6-dependent

42:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:48.6

concentration_units:uM

patient_age:Newborn (0-30 days old)

patient_sex:Female

patient_information:Epilepsy, early-onset, vitamin B6-dependent

43:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:0.16 (0.13-0.18)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Meningitis

44:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:19.2 (16.1-22.3)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Tuberculosis

45:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:4.04 +/- 0.57

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Schizophrenia

46:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal Cancer

47:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Autism

48:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Irritable bowel syndrome

49:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Ulcerative colitis

50:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

51:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Immunoglobulin A nephropathy (IgAN) progressor

52:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:ankylosing spondylitis

53:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:rheumatoid arthritis

54:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Not Specified

patient_sex:Not Specified

patient_information:Cryptosporidium infection

55:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Both

patient_information:Crohns disease

56:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Both

patient_information:Ulcerative colitis

57:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Crohns disease

58:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Ulcerative colitis

59:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Unclassified IBD

60:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Myalgic encephalomyelitis/chronic fatigue syndrome

61:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Crohn disease

62:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Irritable bowel syndrome

63:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

64:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

65:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Irritable Bowel Syndrome

66:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Ulcerative colitis

67:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Not Specified

patient_information:asymptomatic diverticulosis

68:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Not Specified

patient_information:symptomatic uncomplicated diverticular disease

69:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Crohn’s Disease

70:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Ulcerative Colitis

71:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal Cancer

72:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Crohn's disease

73:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

74:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Crohns disease

75:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Ulcerative colitis

76:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

77:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

78:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Gout

79:

biospecimen:Saliva

concentration_value:40.50 +/- 13.83

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Alzheimer's disease

80:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Oral squamous cell carcinoma (OSCC)

81:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Oral leukoplakia (OLK)

82:

biospecimen:Saliva

concentration_value:36.63 +/- 16.68

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Frontotemporal lobe dementia

83:

biospecimen:Saliva

concentration_value:33.94 +/- 19.76

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Lewy body disease

84:

biospecimen:Saliva

concentration_value:23.0 +/- 8.42

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Temporomandibular joint disorder (TMD)

85:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Oral cancer

86:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Breast cancer

87:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Not Specified

patient_information:Pancreatic cancer

88:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Not Specified

patient_information:Periodontal diseases

89:

biospecimen:Urine

concentration_value:427.656-681.457

concentration_units:umol/mmol creatinine

patient_age:Infant (0-1 year old)

patient_sex:Both

patient_information:Amish lethal microcephaly

90:

biospecimen:Urine

concentration_value:23 (10-55)

concentration_units:umol/mmol creatinine

patient_age:Not Specified

patient_sex:Both

patient_information:Lung cancer

91:

biospecimen:Urine

concentration_value:51 +/- 42.068

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Eosinophilic esophagitis

92:

biospecimen:Urine

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

93:

biospecimen:Urine

concentration_value:58.4882 +/- 31.7251

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Eosinophilic esophagitis

94:

biospecimen:Urine

concentration_value:63.2791 +/- 72.6382

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Gastroesophageal reflux disease

95:

biospecimen:Urine

concentration_value:239

concentration_units:umol/mmol creatinine

patient_age:Children (1-13 years old)

patient_sex:Male

patient_information:Lipoyltransferase 1 Deficiency

96:

biospecimen:Urine

concentration_value:76.3

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Paraquat poisoning

疾病参考
1:

name:Dengue fever

omim_id:

[1]:

reference_text:Klassen P, Furst P, Schulz C, Mazariegos M, Solomons NW: Plasma free amino acid concentrations in healthy Guatemalan adults and in patients with classic dengue. Am J Clin Nutr. 2001 Mar;73(3):647-52.

pubmed_id:11237944

2:

name:Epilepsy

omim_id:

[1]:

reference_text:Rainesalo S, Keranen T, Palmio J, Peltola J, Oja SS, Saransaari P: Plasma and cerebrospinal fluid amino acids in epileptic patients. Neurochem Res. 2004 Jan;29(1):319-24.

pubmed_id:14992292

[2]:

reference_text:Cady EB, Lorek A, Penrice J, Reynolds EO, Iles RA, Burns SP, Coutts GA, Cowan FM: Detection of propan-1,2-diol in neonatal brain by in vivo proton magnetic resonance spectroscopy. Magn Reson Med. 1994 Dec;32(6):764-7.

pubmed_id:7869898

[3]:

reference_text:Perosa SR, Porcionatto MA, Cukiert A, Martins JR, Amado D, Nader HB, Cavalheiro EA, Leite JP, Naffah-Mazzacoratti MG: Extracellular matrix components are altered in the hippocampus, cortex, and cerebrospinal fluid of patients with mesial temporal lobe epilepsy. Epilepsia. 2002;43 Suppl 5:159-61.

pubmed_id:12121313

[4]:

reference_text:Spanaki MV, Siegel H, Kopylev L, Fazilat S, Dean A, Liow K, Ben-Menachem E, Gaillard WD, Theodore WH: The effect of vigabatrin (gamma-vinyl GABA) on cerebral blood flow and metabolism. Neurology. 1999 Oct 22;53(7):1518-22.

pubmed_id:10534261

[5]:

reference_text:Rating D, Siemes H, Loscher W: Low CSF GABA concentration in children with febrile convulsions, untreated epilepsy, and meningitis. J Neurol. 1983;230(4):217-25.

pubmed_id:6198481

[6]:

reference_text:Botez MI, Young SN: Effects of anticonvulsant treatment and low levels of folate and thiamine on amine metabolites in cerebrospinal fluid. Brain. 1991 Feb;114 ( Pt 1A):333-48.

pubmed_id:1705463

[7]:

reference_text:Kobayashi K, Koide Y, Yoshino K, Shohmori T: [P-hydroxyphenylacetic acid concentrations in cerebrospinal fluid]. No To Shinkei. 1982 Aug;34(8):769-74.

pubmed_id:7126379

[8]:

reference_text:Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90.

pubmed_id:15993662

[9]:

reference_text:Shaywitz BA, Cohen DJ, Bowers MB: Reduced cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in children with epilepsy. Neurology. 1975 Jan;25(1):72-9.

pubmed_id:803305

[10]:

reference_text:Anagnostouli M, Livaniou E, Nyalala JO, Evangelatos G, Zournas C, Ithakissios DS, Papageorgiou C: Cerebrospinal fluid levels of biotin in various neurological disorders. Acta Neurol Scand. 1999 Jun;99(6):387-92.

pubmed_id:10577274

[11]:

reference_text:Romigi A, Bari M, Placidi F, Marciani MG, Malaponti M, Torelli F, Izzi F, Prosperetti C, Zannino S, Corte F, Chiaramonte C, Maccarrone M: Cerebrospinal fluid levels of the endocannabinoid anandamide are reduced in patients with untreated newly diagnosed temporal lobe epilepsy. Epilepsia. 2010 May;51(5):768-72. doi: 10.1111/j.1528-1167.2009.02334.x. Epub 2009 Oct 8.

pubmed_id:19817812

[12]:

reference_text:Hirai K, Seki T: Cerebrospinal fluid somatostatin levels in febrile seizures and epilepsy in children. Neuropeptides. 2000 Feb;34(1):18-24.

pubmed_id:10688964

[13]:

reference_text:Peters JG: Dopamine, noradrenaline and serotonin spinal fluid metabolites in temporal lobe epileptic patients with schizophrenic symptomatology. Eur Neurol. 1979;18(1):15-8.

pubmed_id:436860

3:

name:Heart failure

omim_id:

[1]:

reference_text:Norrelund H, Wiggers H, Halbirk M, Frystyk J, Flyvbjerg A, Botker HE, Schmitz O, Jorgensen JO, Christiansen JS, Moller N: Abnormalities of whole body protein turnover, muscle metabolism and levels of metabolic hormones in patients with chronic heart failure. J Intern Med. 2006 Jul;260(1):11-21.

pubmed_id:16789974

[2]:

reference_text:Ferreira A, Bettencourt P, Pestana M, Correia F, Serrao P, Martins L, Cerqueira-Gomes M, Soares-Da-Silva P: Heart failure, aging, and renal synthesis of dopamine. Am J Kidney Dis. 2001 Sep;38(3):502-9.

pubmed_id:11532681

[3]:

reference_text:Adams KF Jr, Gheorghiade M, Uretsky BF, Patterson JH, Schwartz TA, Young JB: Clinical benefits of low serum digoxin concentrations in heart failure. J Am Coll Cardiol. 2002 Mar 20;39(6):946-53.

pubmed_id:11897434

[4]:

reference_text:Bhagavan HN, Chopra RK: Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion. 2007 Jun;7 Suppl:S78-88. Epub 2007 Mar 27.

pubmed_id:17482886

[5]:

reference_text:Kang SM, Park JC, Shin MJ, Lee H, Oh J, Ryu DH, Hwang GS, Chung JH: (1)H nuclear magnetic resonance based metabolic urinary profiling of patients with ischemic heart failure. Clin Biochem. 2011 Mar;44(4):293-9. doi: 10.1016/j.clinbiochem.2010.11.010. Epub 2010 Dec 15.

pubmed_id:21167146

4:

name:Early preeclampsia

omim_id:

[1]:

reference_text:Bahado-Singh RO, Akolekar R, Mandal R, Dong E, Xia J, Kruger M, Wishart DS, Nicolaides K: Metabolomics and first-trimester prediction of early-onset preeclampsia. J Matern Fetal Neonatal Med. 2012 Oct;25(10):1840-7. doi: 10.3109/14767058.2012.680254. Epub 2012 Apr 28.

pubmed_id:22494326

5:

name:Pregnancy

omim_id:

[1]:

reference_text:Yang XL, Wu XR: The dynamic changes of several reproductive hormones during termination of early pregnancy by RU486 in combination with PG-05 in Chinese women. Adv Contracept. 1988 Dec;4(4):319-26.

pubmed_id:3252730

[2]:

reference_text:Ball P, Emons G, Haupt O, Hoppen HO, Knuppen R: Radioimmunoassay of 2-hydroxyestrone. Steroids. 1978 Feb;31(2):249-58.

pubmed_id:663967

[3]:

reference_text:Yang YJ, Lee J, Choi MH, Chung BC: Direct determination of estriol 3- and 16-glucuronides in pregnancy urine by column-switching liquid chromatography with electrospray tandem mass spectrometry. Biomed Chromatogr. 2003 Jun;17(4):219-25.

pubmed_id:12833386

[4]:

reference_text:Andreolini F, Borra C, Caccamo F, Di Corcia A, Nicoletti I, Samperi R, Improta F: Estriol and its conjugates in late pregnancy determined by extraction with Carbopack B and liquid chromatography with fluorometric detection. Clin Chem. 1985 Oct;31(10):1698-702.

pubmed_id:2994907

[5]:

reference_text:Huang PC, Kuo PL, Guo YL, Liao PC, Lee CC: Associations between urinary phthalate monoesters and thyroid hormones in pregnant women. Hum Reprod. 2007 Oct;22(10):2715-22. Epub 2007 Aug 17.

pubmed_id:17704099

[6]:

reference_text:Ribar S, Mesaric M, Sedic M: Sphingoid bases as possible diagnostic parameters. Croat Med J. 2003 Apr;44(2):165-70.

pubmed_id:12698507

[7]:

reference_text:Khan HA, Sobki SH, Alhomida AS: Fluctuations in fasting blood glucose and serum fructosamine in pregnant women monitored on successive antenatal visits. Clin Exp Med. 2006 Oct;6(3):134-7.

pubmed_id:17061063

[8]:

reference_text:Mikkelsen TB, Osler M, Olsen SF: Validity of protein, retinol, folic acid and n-3 fatty acid intakes estimated from the food-frequency questionnaire used in the Danish National Birth Cohort. Public Health Nutr. 2006 Sep;9(6):771-8.

pubmed_id:16925883

[9]:

reference_text:Shiraishi M, Haruna M, Matsuzaki M, Murayama R, Sasaki S, Murashima S: Validity and reproducibility of folate and vitamin B(12) intakes estimated from a self-administered diet history questionnaire in Japanese pregnant women. Nutr J. 2012 Mar 15;11:15. doi: 10.1186/1475-2891-11-15.

pubmed_id:22420377

[10]:

reference_text:Brantsaeter AL, Haugen M, Julshamn K, Alexander J, Meltzer HM: Evaluation of urinary iodine excretion as a biomarker for intake of milk and dairy products in pregnant women in the Norwegian Mother and Child Cohort Study (MoBa). Eur J Clin Nutr. 2009 Mar;63(3):347-54. Epub 2007 Dec 5.

pubmed_id:18059417

[11]:

reference_text:Bahado-Singh RO, Akolekar R, Mandal R, Dong E, Xia J, Kruger M, Wishart DS, Nicolaides K: Metabolomics and first-trimester prediction of early-onset preeclampsia. J Matern Fetal Neonatal Med. 2012 Oct;25(10):1840-7. doi: 10.3109/14767058.2012.680254. Epub 2012 Apr 28.

pubmed_id:22494326

[12]:

reference_text:Bahado-Singh RO, Akolekar R, Mandal R, Dong E, Xia J, Kruger M, Wishart DS, Nicolaides K: First-trimester metabolomic detection of late-onset preeclampsia. Am J Obstet Gynecol. 2013 Jan;208(1):58.e1-7. doi: 10.1016/j.ajog.2012.11.003. Epub 2012 Nov 13.

pubmed_id:23159745

[13]:

reference_text:Bahado-Singh RO, Akolekar R, Mandal R, Dong E, Xia J, Kruger M, Wishart DS, Nicolaides K: Metabolomic analysis for first-trimester Down syndrome prediction. Am J Obstet Gynecol. 2013 May;208(5):371.e1-8. doi: 10.1016/j.ajog.2012.12.035. Epub 2013 Jan 8.

pubmed_id:23313728

[14]:

reference_text:Bahado-Singh RO, Akolekar R, Chelliah A, Mandal R, Dong E, Kruger M, Wishart DS, Nicolaides K: Metabolomic analysis for first-trimester trisomy 18 detection. Am J Obstet Gynecol. 2013 Jul;209(1):65.e1-9. doi: 10.1016/j.ajog.2013.03.028. Epub 2013 Mar 25.

pubmed_id:23535240

[15]:

reference_text:Bahado-Singh RO, Ertl R, Mandal R, Bjorndahl TC, Syngelaki A, Han B, Dong E, Liu PB, Alpay-Savasan Z, Wishart DS, Nicolaides KH: Metabolomic prediction of fetal congenital heart defect in the first trimester. Am J Obstet Gynecol. 2014 Sep;211(3):240.e1-240.e14. doi: 10.1016/j.ajog.2014.03.056. Epub 2014 Apr 1.

pubmed_id:24704061

[16]:

reference_text:The Merck Manual, 17th ed. Mark H. Beers, MD, Robert Berkow, MD, eds. Whitehouse Station, NJ: Merck Research Labs, 1999.

pubmed_id:

6:

name:Late-onset preeclampsia

omim_id:

[1]:

reference_text:Bahado-Singh RO, Akolekar R, Mandal R, Dong E, Xia J, Kruger M, Wishart DS, Nicolaides K: First-trimester metabolomic detection of late-onset preeclampsia. Am J Obstet Gynecol. 2013 Jan;208(1):58.e1-7. doi: 10.1016/j.ajog.2012.11.003. Epub 2012 Nov 13.

pubmed_id:23159745

7:

name:N-acetylglutamate synthetase deficiency

omim_id:608300

[1]:

reference_text:Schubiger G, Bachmann C, Barben P, Colombo JP, Tonz O, Schupbach D: N-acetylglutamate synthetase deficiency: diagnosis, management and follow-up of a rare disorder of ammonia detoxication. Eur J Pediatr. 1991 Mar;150(5):353-6.

pubmed_id:2044610

[2]:

reference_text:Guffon N, Vianey-Saban C, Bourgeois J, Rabier D, Colombo JP, Guibaud P: A new neonatal case of N-acetylglutamate synthase deficiency treated by carbamylglutamate. J Inherit Metab Dis. 1995;18(1):61-5.

pubmed_id:7623444

[3]:

reference_text:Hinnie J, Colombo JP, Wermuth B, Dryburgh FJ: N-Acetylglutamate synthetase deficiency responding to carbamylglutamate. J Inherit Metab Dis. 1997 Nov;20(6):839-40.

pubmed_id:9427158

8:

name:Histidinemia

omim_id:235800

[1]:

reference_text:Wevers RA, Engelke U, Wendel U, de Jong JG, Gabreels FJ, Heerschap A: Standardized method for high-resolution 1H-NMR of cerebrospinal fluid. Clin Chem. 1995 May;41(5):744-51.

pubmed_id:7729054

[2]:

reference_text:Imamura I, Watanabe T, Sakamoto Y, Wakamiya T, Shiba T, Hase Y, Tsuruhara T, Wada H: N tau-Ribosylhistidine, a novel histidine derivative in urine of histidinemic patients. Isolation, structure, and tissue level. J Biol Chem. 1985 Sep 5;260(19):10528-30.

pubmed_id:4030756

[3]:

reference_text:Nyhan WL, Hilton S: Histidinuria: defective transport of histidine. Am J Med Genet. 1992 Nov 15;44(5):558-61.

pubmed_id:1481808

[4]:

reference_text:Anakura M, Matsuda I, Arashima S, Fukushima N, Oka Y: Histidinemia. Classical and atypical form in siblings. Am J Dis Child. 1975 Jul;129(7):858-61.

pubmed_id:1146783

[5]:

reference_text:Swarna M, Jyothy A, Usha Rani P, Reddy PP: Amino acid disorders in mental retardation: a two-decade study from Andhra Pradesh. Biochem Genet. 2004 Apr;42(3-4):85-98.

pubmed_id:15168722

[6]:

reference_text:LADU BN, HOWELL RR, JACOBY GA, SEEGMILLER JE, SOBER EK, ZANNONI VG, CANBY JP, ZIEGLER LK: CLINICAL AND BIOCHEMICAL STUDIES ON TWO CASES OF HISTIDINEMIA. Pediatrics. 1963 Aug;32:216-27.

pubmed_id:14044449

9:

name:Glucagon deficiency

omim_id:

[1]:

reference_text:Vidnes J, Oyasaeter S: Glucagon deficiency causing severe neonatal hypoglycemia in a patient with normal insulin secretion. Pediatr Res. 1977 Sep;11(9 Pt 1):943-9.

pubmed_id:904979

10:

name:Dihydrolipoamide Dehydrogenase Deficiency

omim_id:246900

[1]:

reference_text:Kumps A, Duez P, Mardens Y: Metabolic, nutritional, iatrogenic, and artifactual sources of urinary organic acids: a comprehensive table. Clin Chem. 2002 May;48(5):708-17.

pubmed_id:11978597

[2]:

reference_text:Kuhara T, Shinka T, Inoue Y, Matsumoto M, Yoshino M, Sakaguchi Y, Matsumoto I: Studies of urinary organic acid profiles of a patient with dihydrolipoyl dehydrogenase deficiency. Clin Chim Acta. 1983 Sep 30;133(2):133-40.

pubmed_id:6688766

11:

name:Pyruvate dehydrogenase phosphatase deficiency

omim_id:608782

[1]:

reference_text:Robinson BH, Sherwood WG: Pyruvate dehydrogenase phosphatase deficiency: a cause of congenital chronic lactic acidosis in infancy. Pediatr Res. 1975 Dec;9(12):935-9. doi: 10.1203/00006450-197512000-00015.

pubmed_id:172850

12:

name:Pearson Syndrome

omim_id:557000

[1]:

reference_text:Crippa BL, Leon E, Calhoun A, Lowichik A, Pasquali M, Longo N: Biochemical abnormalities in Pearson syndrome. Am J Med Genet A. 2015 Mar;167A(3):621-8. doi: 10.1002/ajmg.a.36939.

pubmed_id:25691415

13:

name:Coenzyme Q10 deficiency, primary, 5

omim_id:614654

[1]:

reference_text:Danhauser K, Herebian D, Haack TB, Rodenburg RJ, Strom TM, Meitinger T, Klee D, Mayatepek E, Prokisch H, Distelmaier F: Fatal neonatal encephalopathy and lactic acidosis caused by a homozygous loss-of-function variant in COQ9. Eur J Hum Genet. 2016 Mar;24(3):450-4. doi: 10.1038/ejhg.2015.133. Epub 2015 Jun 17.

pubmed_id:26081641

14:

name:Pyruvate carboxylase deficiency

omim_id:266150

[1]:

reference_text:Habarou F, Brassier A, Rio M, Chretien D, Monnot S, Barbier V, Barouki R, Bonnefont JP, Boddaert N, Chadefaux-Vekemans B, Le Moyec L, Bastin J, Ottolenghi C, de Lonlay P: Pyruvate carboxylase deficiency: An underestimated cause of lactic acidosis. Mol Genet Metab Rep. 2014 Nov 28;2:25-31. doi: 10.1016/j.ymgmr.2014.11.001. eCollection 2015 Mar.

pubmed_id:28649521

15:

name:Mitochondrial pyruvate carrier deficiency

omim_id:614741

[1]:

reference_text:Brivet M, Garcia-Cazorla A, Lyonnet S, Dumez Y, Nassogne MC, Slama A, Boutron A, Touati G, Legrand A, Saudubray JM: Impaired mitochondrial pyruvate importation in a patient and a fetus at risk. Mol Genet Metab. 2003 Mar;78(3):186-92.

pubmed_id:12649063

16:

name:Lipoyltransferase 1 Deficiency

omim_id:616299

[1]:

reference_text:Soreze Y, Boutron A, Habarou F, Barnerias C, Nonnenmacher L, Delpech H, Mamoune A, Chretien D, Hubert L, Bole-Feysot C, Nitschke P, Correia I, Sardet C, Boddaert N, Hamel Y, Delahodde A, Ottolenghi C, de Lonlay P: Mutations in human lipoyltransferase gene LIPT1 cause a Leigh disease with secondary deficiency for pyruvate and alpha-ketoglutarate dehydrogenase. Orphanet J Rare Dis. 2013 Dec 17;8:192. doi: 10.1186/1750-1172-8-192.

pubmed_id:24341803

17:

name:Meningitis

omim_id:

[1]:

reference_text:Rodriguez-Nunez A, Cid E, Rodriguez-Garcia J, Camina F, Rodriguez-Segade S, Castro-Gago M: Neuron-specific enolase, nucleotides, nucleosides, purine bases, oxypurines and uric acid concentrations in cerebrospinal fluid of children with meningitis. Brain Dev. 2003 Mar;25(2):102-6.

pubmed_id:12581805

[2]:

reference_text:Subramanian A, Gupta A, Saxena S, Gupta A, Kumar R, Nigam A, Kumar R, Mandal SK, Roy R: Proton MR CSF analysis and a new software as predictors for the differentiation of meningitis in children. NMR Biomed. 2005 Jun;18(4):213-25.

pubmed_id:15627241

[3]:

reference_text:Wevers RA, Engelke U, Wendel U, de Jong JG, Gabreels FJ, Heerschap A: Standardized method for high-resolution 1H-NMR of cerebrospinal fluid. Clin Chem. 1995 May;41(5):744-51.

pubmed_id:7729054

[4]:

reference_text:Qureshi GA, Baig SM, Bednar I, Halawa A, Parvez SH: The neurochemical markers in cerebrospinal fluid to differentiate between aseptic and tuberculous meningitis. Neurochem Int. 1998 Feb;32(2):197-203.

pubmed_id:9542731

[5]:

reference_text:Leoni V, Masterman T, Mousavi FS, Wretlind B, Wahlund LO, Diczfalusy U, Hillert J, Bjorkhem I: Diagnostic use of cerebral and extracerebral oxysterols. Clin Chem Lab Med. 2004 Feb;42(2):186-91.

pubmed_id:15061359

[6]:

reference_text:Kastenbauer S, Koedel U, Becker BF, Pfister HW: Oxidative stress in bacterial meningitis in humans. Neurology. 2002 Jan 22;58(2):186-91.

pubmed_id:11805243

[7]:

reference_text:Lerche A, Svenson M, Wiik A: Cerebrospinal fluid levels of cyclic nucleotides in meningitis and idiopathic polyneuritis. Acta Neurol Scand. 1984 Mar;69(3):168-75.

pubmed_id:6326460

[8]:

reference_text:Silva SO, Ximenes VF, Livramento JA, Catalani LH, Campa A: High concentrations of the melatonin metabolite, N1-acetyl-N2-formyl-5-methoxykynuramine, in cerebrospinal fluid of patients with meningitis: a possible immunomodulatory mechanism. J Pineal Res. 2005 Oct;39(3):302-6.

pubmed_id:16150112

[9]:

reference_text:Rating D, Siemes H, Loscher W: Low CSF GABA concentration in children with febrile convulsions, untreated epilepsy, and meningitis. J Neurol. 1983;230(4):217-25.

pubmed_id:6198481

[10]:

reference_text:Westcott JY, Murphy RC, Stenmark K: Eicosanoids in human ventricular cerebrospinal fluid following severe brain injury. Prostaglandins. 1987 Dec;34(6):877-87.

pubmed_id:2835791

[11]:

reference_text:Laurent UB, Laurent TC, Hellsing LK, Persson L, Hartman M, Lilja K: Hyaluronan in human cerebrospinal fluid. Acta Neurol Scand. 1996 Sep;94(3):194-206.

pubmed_id:8899053

18:

name:Tuberculosis

omim_id:607948

[1]:

reference_text:Wevers RA, Engelke U, Wendel U, de Jong JG, Gabreels FJ, Heerschap A: Standardized method for high-resolution 1H-NMR of cerebrospinal fluid. Clin Chem. 1995 May;41(5):744-51.

pubmed_id:7729054

[2]:

reference_text:Upton A, Woodhouse A, Vaughan R, Newton S, Ellis-Pegler R: Evolution of central nervous system multidrug-resistant Mycobacterium tuberculosis and late relapse of cryptic prosthetic hip joint tuberculosis: complications during treatment of disseminated isoniazid-resistant tuberculosis in an immunocompromised host. J Clin Microbiol. 2009 Feb;47(2):507-10. doi: 10.1128/JCM.01473-08. Epub 2008 Dec 24.

pubmed_id:19109477

19:

name:Leukemia

omim_id:

[1]:

reference_text:Lee SH, Suh JW, Chung BC, Kim SO: Polyamine profiles in the urine of patients with leukemia. Cancer Lett. 1998 Jan 9;122(1-2):1-8.

pubmed_id:9464484

[2]:

reference_text:Curtius HC, Wolfensberger M, Redweik U, Leimbacher W, Maibach RA, Isler W: Mass fragmentography of 5-hydroxytryptophol and 5-methoxytryptophol in human cerebrospinal fluid. J Chromatogr. 1975 Oct 29;112:523-31.

pubmed_id:1184685

[3]:

reference_text:Peng CT, Wu KH, Lan SJ, Tsai JJ, Tsai FJ, Tsai CH: Amino acid concentrations in cerebrospinal fluid in children with acute lymphoblastic leukemia undergoing chemotherapy. Eur J Cancer. 2005 May;41(8):1158-63. Epub 2005 Apr 14.

pubmed_id:15911239

[4]:

reference_text:Ishiwata S, Itoh K, Yamaguchi T, Ishida N, Mizugaki M: Comparison of serum and urinary levels of modified nucleoside, 1-methyladenosine, in cancer patients using a monoclonal antibody-based inhibition ELISA. Tohoku J Exp Med. 1995 May;176(1):61-8.

pubmed_id:7482520

[5]:

reference_text:Silvennoinen R, Malminiemi K, Malminiemi O, Seppala E, Vilpo J: Pharmacokinetics of chlorambucil in patients with chronic lymphocytic leukaemia: comparison of different days, cycles and doses. Pharmacol Toxicol. 2000 Nov;87(5):223-8.

pubmed_id:11129502

20:

name:Schizophrenia

omim_id:181500

[1]:

reference_text:Harnryd C, Bjerkenstedt L, Grimm VE, Sedvall G: Reduction of MOPEG levels in cerebrospinal fluid of psychotic women after electroconvulsive treatment. Psychopharmacology (Berl). 1979 Aug 8;64(2):131-4.

pubmed_id:115032

[2]:

reference_text:Kobayashi K, Koide Y, Yoshino K, Shohmori T: [P-hydroxyphenylacetic acid concentrations in cerebrospinal fluid]. No To Shinkei. 1982 Aug;34(8):769-74.

pubmed_id:7126379

[3]:

reference_text:Alfredsson G, Wiesel FA: Monoamine metabolites and amino acids in serum from schizophrenic patients before and during sulpiride treatment. Psychopharmacology (Berl). 1989;99(3):322-7.

pubmed_id:2480613

[4]:

reference_text:Heresco-Levy U, Bar G, Levin R, Ermilov M, Ebstein RP, Javitt DC: High glycine levels are associated with prepulse inhibition deficits in chronic schizophrenia patients. Schizophr Res. 2007 Mar;91(1-3):14-21. Epub 2007 Feb 2.

pubmed_id:17276036

[5]:

reference_text:Walker EF, Bonsall R, Walder DJ: Plasma hormones and catecholamine metabolites in monozygotic twins discordant for psychosis. Neuropsychiatry Neuropsychol Behav Neurol. 2002 Mar;15(1):10-7.

pubmed_id:11877547

[6]:

reference_text:Hashimoto K, Fukushima T, Shimizu E, Komatsu N, Watanabe H, Shinoda N, Nakazato M, Kumakiri C, Okada S, Hasegawa H, Imai K, Iyo M: Decreased serum levels of D-serine in patients with schizophrenia: evidence in support of the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia. Arch Gen Psychiatry. 2003 Jun;60(6):572-6.

pubmed_id:12796220

[7]:

reference_text:Do KQ, Lauer CJ, Schreiber W, Zollinger M, Gutteck-Amsler U, Cuenod M, Holsboer F: gamma-Glutamylglutamine and taurine concentrations are decreased in the cerebrospinal fluid of drug-naive patients with schizophrenic disorders. J Neurochem. 1995 Dec;65(6):2652-62.

pubmed_id:7595563

[8]:

reference_text:Nikisch G, Baumann P, Wiedemann G, Kiessling B, Weisser H, Hertel A, Yoshitake T, Kehr J, Mathe AA: Quetiapine and norquetiapine in plasma and cerebrospinal fluid of schizophrenic patients treated with quetiapine: correlations to clinical outcome and HVA, 5-HIAA, and MHPG in CSF. J Clin Psychopharmacol. 2010 Oct;30(5):496-503. doi: 10.1097/JCP.0b013e3181f2288e.

pubmed_id:20814316

[9]:

reference_text:Fukushima T, Iizuka H, Yokota A, Suzuki T, Ohno C, Kono Y, Nishikiori M, Seki A, Ichiba H, Watanabe Y, Hongo S, Utsunomiya M, Nakatani M, Sadamoto K, Yoshio T: Quantitative analyses of schizophrenia-associated metabolites in serum: serum D-lactate levels are negatively correlated with gamma-glutamylcysteine in medicated schizophrenia patients. PLoS One. 2014 Jul 8;9(7):e101652. doi: 10.1371/journal.pone.0101652. eCollection 2014.

pubmed_id:25004141

[10]:

reference_text:Koike S, Bundo M, Iwamoto K, Suga M, Kuwabara H, Ohashi Y, Shinoda K, Takano Y, Iwashiro N, Satomura Y, Nagai T, Natsubori T, Tada M, Yamasue H, Kasai K: A snapshot of plasma metabolites in first-episode schizophrenia: a capillary electrophoresis time-of-flight mass spectrometry study. Transl Psychiatry. 2014 Apr 8;4:e379. doi: 10.1038/tp.2014.19.

pubmed_id:24713860

[11]:

reference_text:Ballesteros A, Summerfelt A, Du X, Jiang P, Chiappelli J, Tagamets M, O'Donnell P, Kochunov P, Hong LE: Electrophysiological intermediate biomarkers for oxidative stress in schizophrenia. Clin Neurophysiol. 2013 Nov;124(11):2209-15. doi: 10.1016/j.clinph.2013.05.021. Epub 2013 Jun 30.

pubmed_id:23823132

[12]:

reference_text:Bjerkenstedt L, Edman G, Hagenfeldt L, Sedvall G, Wiesel FA: Plasma amino acids in relation to cerebrospinal fluid monoamine metabolites in schizophrenic patients and healthy controls. Br J Psychiatry. 1985 Sep;147:276-82.

pubmed_id:2415198

[13]:

reference_text:Pickar D, Breier A, Hsiao JK, Doran AR, Wolkowitz OM, Pato CN, Konicki PE, Potter WZ: Cerebrospinal fluid and plasma monoamine metabolites and their relation to psychosis. Implications for regional brain dysfunction in schizophrenia. Arch Gen Psychiatry. 1990 Jul;47(7):641-8.

pubmed_id:1694425

[14]:

reference_text:Prell GD, Green JP, Kaufmann CA, Khandelwal JK, Morrishow AM, Kirch DG, Linnoila M, Wyatt RJ: Histamine metabolites in cerebrospinal fluid of patients with chronic schizophrenia: their relationships to levels of other aminergic transmitters and ratings of symptoms. Schizophr Res. 1995 Jan;14(2):93-104.

pubmed_id:7711000

[15]:

reference_text:Kim YK, Myint AM, Verkerk R, Scharpe S, Steinbusch H, Leonard B: Cytokine changes and tryptophan metabolites in medication-naive and medication-free schizophrenic patients. Neuropsychobiology. 2009;59(2):123-9. doi: 10.1159/000213565. Epub 2009 Apr 22.

pubmed_id:19390223

[16]:

reference_text:Yang J, Chen T, Sun L, Zhao Z, Qi X, Zhou K, Cao Y, Wang X, Qiu Y, Su M, Zhao A, Wang P, Yang P, Wu J, Feng G, He L, Jia W, Wan C: Potential metabolite markers of schizophrenia. Mol Psychiatry. 2013 Jan;18(1):67-78. doi: 10.1038/mp.2011.131. Epub 2011 Oct 25.

pubmed_id:22024767

[17]:

reference_text:Xuan J, Pan G, Qiu Y, Yang L, Su M, Liu Y, Chen J, Feng G, Fang Y, Jia W, Xing Q, He L: Metabolomic profiling to identify potential serum biomarkers for schizophrenia and risperidone action. J Proteome Res. 2011 Dec 2;10(12):5433-43. doi: 10.1021/pr2006796. Epub 2011 Nov 8.

pubmed_id:22007635

[18]:

reference_text:Schwarz E, Guest PC, Rahmoune H, Harris LW, Wang L, Leweke FM, Rothermundt M, Bogerts B, Koethe D, Kranaster L, Ohrmann P, Suslow T, McAllister G, Spain M, Barnes A, van Beveren NJ, Baron-Cohen S, Steiner J, Torrey FE, Yolken RH, Bahn S: Identification of a biological signature for schizophrenia in serum. Mol Psychiatry. 2012 May;17(5):494-502. doi: 10.1038/mp.2011.42. Epub 2011 Apr 12.

pubmed_id:21483431

[19]:

reference_text:Mathe AA, Eberhard G, Saaf J, Wetterberg L: Plasma prostaglandin E2 metabolite--measured as 11-deoxy-15-keto-13,14-dihydro-11 beta,16 xi-cyclo-PGE2--in twins with schizophrenic disorder. Biol Psychiatry. 1986 Sep;21(11):1024-30.

pubmed_id:3741918

[20]:

reference_text:Kuloglu M, Ustundag B, Atmaca M, Canatan H, Tezcan AE, Cinkilinc N: Lipid peroxidation and antioxidant enzyme levels in patients with schizophrenia and bipolar disorder. Cell Biochem Funct. 2002 Jun;20(2):171-5.

pubmed_id:11979513

[21]:

reference_text:Zumarraga M, Davila R, Basterreche N, Arrue A, Goienetxea B, Zamalloa MI, Erkoreka L, Bustamante S, Inchausti L, Gonzalez-Torres MA, Guimon J: Catechol O-methyltransferase and monoamine oxidase A genotypes, and plasma catecholamine metabolites in bipolar and schizophrenic patients. Neurochem Int. 2010 May-Jun;56(6-7):774-9. doi: 10.1016/j.neuint.2010.02.015. Epub 2010 Mar 4.

pubmed_id:20206656

[22]:

reference_text:Peters JG: Dopamine, noradrenaline and serotonin spinal fluid metabolites in temporal lobe epileptic patients with schizophrenic symptomatology. Eur Neurol. 1979;18(1):15-8.

pubmed_id:436860

[23]:

reference_text:Yao JK, Dougherty GG Jr, Reddy RD, Keshavan MS, Montrose DM, Matson WR, Rozen S, Krishnan RR, McEvoy J, Kaddurah-Daouk R: Altered interactions of tryptophan metabolites in first-episode neuroleptic-naive patients with schizophrenia. Mol Psychiatry. 2010 Sep;15(9):938-53. doi: 10.1038/mp.2009.33. Epub 2009 Apr 28.

pubmed_id:19401681

[24]:

reference_text:Gattaz WF, Waldmeier P, Beckmann H: CSF monoamine metabolites in schizophrenic patients. Acta Psychiatr Scand. 1982 Nov;66(5):350-60.

pubmed_id:6184954

[25]:

reference_text:Nilsson-Todd LK, Nordin C, Jonsson EG, Skogh E, Erhardt S: Cerebrospinal fluid kynurenic acid in male patients with schizophrenia - correlation with monoamine metabolites. Acta Neuropsychiatr. 2007 Feb;19(1):45-52. doi: 10.1111/j.1601-5215.2006.00170.x.

pubmed_id:26952797

[26]:

reference_text:Cai HL, Li HD, Yan XZ, Sun B, Zhang Q, Yan M, Zhang WY, Jiang P, Zhu RH, Liu YP, Fang PF, Xu P, Yuan HY, Zhang XH, Hu L, Yang W, Ye HS: Metabolomic analysis of biochemical changes in the plasma and urine of first-episode neuroleptic-naive schizophrenia patients after treatment with risperidone. J Proteome Res. 2012 Aug 3;11(8):4338-50. doi: 10.1021/pr300459d. Epub 2012 Jul 26.

pubmed_id:22800120

[27]:

reference_text:Al Awam K, Haussleiter IS, Dudley E, Donev R, Brune M, Juckel G, Thome J: Multiplatform metabolome and proteome profiling identifies serum metabolite and protein signatures as prospective biomarkers for schizophrenia. J Neural Transm (Vienna). 2015 Aug;122 Suppl 1:S111-22. doi: 10.1007/s00702-014-1224-0. Epub 2014 May 1.

pubmed_id:24789758

[28]:

reference_text:Bicikova M, Hill M, Ripova D, Mohr P, Hampl R: Determination of steroid metabolome as a possible tool for laboratory diagnosis of schizophrenia. J Steroid Biochem Mol Biol. 2013 Jan;133:77-83. doi: 10.1016/j.jsbmb.2012.08.009. Epub 2012 Aug 24.

pubmed_id:22944140

[29]:

reference_text:He Y, Yu Z, Giegling I, Xie L, Hartmann AM, Prehn C, Adamski J, Kahn R, Li Y, Illig T, Wang-Sattler R, Rujescu D: Schizophrenia shows a unique metabolomics signature in plasma. Transl Psychiatry. 2012 Aug 14;2:e149. doi: 10.1038/tp.2012.76.

pubmed_id:22892715

[30]:

reference_text:Kaddurah-Daouk R, McEvoy J, Baillie RA, Lee D, Yao JK, Doraiswamy PM, Krishnan KR: Metabolomic mapping of atypical antipsychotic effects in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):934-45. Epub 2007 Apr 17.

pubmed_id:17440431

[31]:

reference_text:Fryar-Williams S, Strobel JE: Biomarkers of a five-domain translational substrate for schizophrenia and schizoaffective psychosis. Biomark Res. 2015 Feb 6;3:3. doi: 10.1186/s40364-015-0028-1. eCollection 2015.

pubmed_id:25729574

[32]:

reference_text:Oresic M, Seppanen-Laakso T, Sun D, Tang J, Therman S, Viehman R, Mustonen U, van Erp TG, Hyotylainen T, Thompson P, Toga AW, Huttunen MO, Suvisaari J, Kaprio J, Lonnqvist J, Cannon TD: Phospholipids and insulin resistance in psychosis: a lipidomics study of twin pairs discordant for schizophrenia. Genome Med. 2012 Jan 18;4(1):1. doi: 10.1186/gm300.

pubmed_id:22257447

21:

name:Epilepsy, early-onset, vitamin B6-dependent

omim_id:617290

[1]:

reference_text:Darin N, Reid E, Prunetti L, Samuelsson L, Husain RA, Wilson M, El Yacoubi B, Footitt E, Chong WK, Wilson LC, Prunty H, Pope S, Heales S, Lascelles K, Champion M, Wassmer E, Veggiotti P, de Crecy-Lagard V, Mills PB, Clayton PT: Mutations in PROSC Disrupt Cellular Pyridoxal Phosphate Homeostasis and Cause Vitamin-B6-Dependent Epilepsy. Am J Hum Genet. 2016 Dec 1;99(6):1325-1337. doi: 10.1016/j.ajhg.2016.10.011.

pubmed_id:27912044

22:

name:Crohn's disease

omim_id:266600

[1]:

reference_text:Lapidus A, Akerlund JE, Einarsson C: Gallbladder bile composition in patients with Crohn 's disease. World J Gastroenterol. 2006 Jan 7;12(1):70-4.

pubmed_id:16440420

[2]:

reference_text:Ehrenpreis ED, Salvino M, Craig RM: Improving the serum D-xylose test for the identification of patients with small intestinal malabsorption. J Clin Gastroenterol. 2001 Jul;33(1):36-40.

pubmed_id:11418788

[3]:

reference_text:Brydon WG, Nyhlin H, Eastwood MA, Merrick MV: Serum 7 alpha-hydroxy-4-cholesten-3-one and selenohomocholyltaurine (SeHCAT) whole body retention in the assessment of bile acid induced diarrhoea. Eur J Gastroenterol Hepatol. 1996 Feb;8(2):117-23.

pubmed_id:8723414

[4]:

reference_text:Williams HR, Cox IJ, Walker DG, North BV, Patel VM, Marshall SE, Jewell DP, Ghosh S, Thomas HJ, Teare JP, Jakobovits S, Zeki S, Welsh KI, Taylor-Robinson SD, Orchard TR: Characterization of inflammatory bowel disease with urinary metabolic profiling. Am J Gastroenterol. 2009 Jun;104(6):1435-44. doi: 10.1038/ajg.2009.175. Epub 2009 Apr 28.

pubmed_id:19491857

[5]:

reference_text:Marchesi JR, Holmes E, Khan F, Kochhar S, Scanlan P, Shanahan F, Wilson ID, Wang Y: Rapid and noninvasive metabonomic characterization of inflammatory bowel disease. J Proteome Res. 2007 Feb;6(2):546-51.

pubmed_id:17269711

[6]:

reference_text:Ahmed I, Greenwood R, Costello Bde L, Ratcliffe NM, Probert CS: An investigation of fecal volatile organic metabolites in irritable bowel syndrome. PLoS One. 2013;8(3):e58204. doi: 10.1371/journal.pone.0058204. Epub 2013 Mar 13.

pubmed_id:23516449

[7]:

reference_text:Walton C, Fowler DP, Turner C, Jia W, Whitehead RN, Griffiths L, Dawson C, Waring RH, Ramsden DB, Cole JA, Cauchi M, Bessant C, Hunter JO: Analysis of volatile organic compounds of bacterial origin in chronic gastrointestinal diseases. Inflamm Bowel Dis. 2013 Sep;19(10):2069-78. doi: 10.1097/MIB.0b013e31829a91f6.

pubmed_id:23867873

[8]:

reference_text:De Preter V, Machiels K, Joossens M, Arijs I, Matthys C, Vermeire S, Rutgeerts P, Verbeke K: Faecal metabolite profiling identifies medium-chain fatty acids as discriminating compounds in IBD. Gut. 2015 Mar;64(3):447-58. doi: 10.1136/gutjnl-2013-306423. Epub 2014 May 8.

pubmed_id:24811995

[9]:

reference_text:Bjerrum JT, Wang Y, Hao F, Coskun M, Ludwig C, Gunther U, Nielsen OH: Metabonomics of human fecal extracts characterize ulcerative colitis, Crohn's disease and healthy individuals. Metabolomics. 2015;11:122-133. Epub 2014 Jun 1.

pubmed_id:25598765

[10]:

reference_text:Ahmed I, Greenwood R, Costello B, Ratcliffe N, Probert CS: Investigation of faecal volatile organic metabolites as novel diagnostic biomarkers in inflammatory bowel disease. Aliment Pharmacol Ther. 2016 Mar;43(5):596-611. doi: 10.1111/apt.13522. Epub 2016 Jan 25.

pubmed_id:26806034

[11]:

reference_text:Lee T, Clavel T, Smirnov K, Schmidt A, Lagkouvardos I, Walker A, Lucio M, Michalke B, Schmitt-Kopplin P, Fedorak R, Haller D: Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD. Gut. 2017 May;66(5):863-871. doi: 10.1136/gutjnl-2015-309940. Epub 2016 Feb 4.

pubmed_id:26848182

[12]:

reference_text:Kolho KL, Pessia A, Jaakkola T, de Vos WM, Velagapudi V: Faecal and Serum Metabolomics in Paediatric Inflammatory Bowel Disease. J Crohns Colitis. 2017 Mar 1;11(3):321-334. doi: 10.1093/ecco-jcc/jjw158.

pubmed_id:27609529

[13]:

reference_text:Azario I, Pievani A, Del Priore F, Antolini L, Santi L, Corsi A, Cardinale L, Sawamoto K, Kubaski F, Gentner B, Bernardo ME, Valsecchi MG, Riminucci M, Tomatsu S, Aiuti A, Biondi A, Serafini M: Neonatal umbilical cord blood transplantation halts skeletal disease progression in the murine model of MPS-I. Sci Rep. 2017 Aug 25;7(1):9473. doi: 10.1038/s41598-017-09958-9.

pubmed_id:28842642

23:

name:Ulcerative colitis

omim_id:

[1]:

reference_text:Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. doi: 10.1093/nar/gkq1126. Epub 2010 Nov 8.

pubmed_id:21059682

[2]:

reference_text:Almer S, Andersson T, Strom M: Pharmacokinetics of tranexamic acid in patients with ulcerative colitis and in healthy volunteers after the single instillation of 2 g rectally. J Clin Pharmacol. 1992 Jan;32(1):49-54.

pubmed_id:1740537

[3]:

reference_text:Marchesi JR, Holmes E, Khan F, Kochhar S, Scanlan P, Shanahan F, Wilson ID, Wang Y: Rapid and noninvasive metabonomic characterization of inflammatory bowel disease. J Proteome Res. 2007 Feb;6(2):546-51.

pubmed_id:17269711

[4]:

reference_text:Garner CE, Smith S, de Lacy Costello B, White P, Spencer R, Probert CS, Ratcliffe NM: Volatile organic compounds from feces and their potential for diagnosis of gastrointestinal disease. FASEB J. 2007 Jun;21(8):1675-88. Epub 2007 Feb 21.

pubmed_id:17314143

[5]:

reference_text:Le Gall G, Noor SO, Ridgway K, Scovell L, Jamieson C, Johnson IT, Colquhoun IJ, Kemsley EK, Narbad A: Metabolomics of fecal extracts detects altered metabolic activity of gut microbiota in ulcerative colitis and irritable bowel syndrome. J Proteome Res. 2011 Sep 2;10(9):4208-18. doi: 10.1021/pr2003598. Epub 2011 Aug 8.

pubmed_id:21761941

[6]:

reference_text:Ahmed I, Greenwood R, Costello Bde L, Ratcliffe NM, Probert CS: An investigation of fecal volatile organic metabolites in irritable bowel syndrome. PLoS One. 2013;8(3):e58204. doi: 10.1371/journal.pone.0058204. Epub 2013 Mar 13.

pubmed_id:23516449

[7]:

reference_text:Walton C, Fowler DP, Turner C, Jia W, Whitehead RN, Griffiths L, Dawson C, Waring RH, Ramsden DB, Cole JA, Cauchi M, Bessant C, Hunter JO: Analysis of volatile organic compounds of bacterial origin in chronic gastrointestinal diseases. Inflamm Bowel Dis. 2013 Sep;19(10):2069-78. doi: 10.1097/MIB.0b013e31829a91f6.

pubmed_id:23867873

[8]:

reference_text:De Preter V, Machiels K, Joossens M, Arijs I, Matthys C, Vermeire S, Rutgeerts P, Verbeke K: Faecal metabolite profiling identifies medium-chain fatty acids as discriminating compounds in IBD. Gut. 2015 Mar;64(3):447-58. doi: 10.1136/gutjnl-2013-306423. Epub 2014 May 8.

pubmed_id:24811995

[9]:

reference_text:Bjerrum JT, Wang Y, Hao F, Coskun M, Ludwig C, Gunther U, Nielsen OH: Metabonomics of human fecal extracts characterize ulcerative colitis, Crohn's disease and healthy individuals. Metabolomics. 2015;11:122-133. Epub 2014 Jun 1.

pubmed_id:25598765

[10]:

reference_text:Ahmed I, Greenwood R, Costello B, Ratcliffe N, Probert CS: Investigation of faecal volatile organic metabolites as novel diagnostic biomarkers in inflammatory bowel disease. Aliment Pharmacol Ther. 2016 Mar;43(5):596-611. doi: 10.1111/apt.13522. Epub 2016 Jan 25.

pubmed_id:26806034

[11]:

reference_text:Lee T, Clavel T, Smirnov K, Schmidt A, Lagkouvardos I, Walker A, Lucio M, Michalke B, Schmitt-Kopplin P, Fedorak R, Haller D: Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD. Gut. 2017 May;66(5):863-871. doi: 10.1136/gutjnl-2015-309940. Epub 2016 Feb 4.

pubmed_id:26848182

[12]:

reference_text:Kolho KL, Pessia A, Jaakkola T, de Vos WM, Velagapudi V: Faecal and Serum Metabolomics in Paediatric Inflammatory Bowel Disease. J Crohns Colitis. 2017 Mar 1;11(3):321-334. doi: 10.1093/ecco-jcc/jjw158.

pubmed_id:27609529

[13]:

reference_text:Azario I, Pievani A, Del Priore F, Antolini L, Santi L, Corsi A, Cardinale L, Sawamoto K, Kubaski F, Gentner B, Bernardo ME, Valsecchi MG, Riminucci M, Tomatsu S, Aiuti A, Biondi A, Serafini M: Neonatal umbilical cord blood transplantation halts skeletal disease progression in the murine model of MPS-I. Sci Rep. 2017 Aug 25;7(1):9473. doi: 10.1038/s41598-017-09958-9.

pubmed_id:28842642

24:

name:Colorectal cancer

omim_id:114500

[1]:

reference_text:Ishiwata S, Itoh K, Yamaguchi T, Ishida N, Mizugaki M: Comparison of serum and urinary levels of modified nucleoside, 1-methyladenosine, in cancer patients using a monoclonal antibody-based inhibition ELISA. Tohoku J Exp Med. 1995 May;176(1):61-8.

pubmed_id:7482520

[2]:

reference_text:Monleon D, Morales JM, Barrasa A, Lopez JA, Vazquez C, Celda B: Metabolite profiling of fecal water extracts from human colorectal cancer. NMR Biomed. 2009 Apr;22(3):342-8. doi: 10.1002/nbm.1345.

pubmed_id:19006102

[3]:

reference_text:Weir TL, Manter DK, Sheflin AM, Barnett BA, Heuberger AL, Ryan EP: Stool microbiome and metabolome differences between colorectal cancer patients and healthy adults. PLoS One. 2013 Aug 6;8(8):e70803. doi: 10.1371/journal.pone.0070803. Print 2013.

pubmed_id:23940645

[4]:

reference_text:Phua LC, Chue XP, Koh PK, Cheah PY, Ho HK, Chan EC: Non-invasive fecal metabonomic detection of colorectal cancer. Cancer Biol Ther. 2014 Apr;15(4):389-97. doi: 10.4161/cbt.27625. Epub 2014 Jan 14.

pubmed_id:24424155

[5]:

reference_text:Ritchie SA, Ahiahonu PW, Jayasinghe D, Heath D, Liu J, Lu Y, Jin W, Kavianpour A, Yamazaki Y, Khan AM, Hossain M, Su-Myat KK, Wood PL, Krenitsky K, Takemasa I, Miyake M, Sekimoto M, Monden M, Matsubara H, Nomura F, Goodenowe DB: Reduced levels of hydroxylated, polyunsaturated ultra long-chain fatty acids in the serum of colorectal cancer patients: implications for early screening and detection. BMC Med. 2010 Feb 15;8:13. doi: 10.1186/1741-7015-8-13.

pubmed_id:20156336

[6]:

reference_text:Qiu Y, Cai G, Su M, Chen T, Zheng X, Xu Y, Ni Y, Zhao A, Xu LX, Cai S, Jia W: Serum metabolite profiling of human colorectal cancer using GC-TOFMS and UPLC-QTOFMS. J Proteome Res. 2009 Oct;8(10):4844-50. doi: 10.1021/pr9004162.

pubmed_id:19678709

[7]:

reference_text:Cheng Y, Xie G, Chen T, Qiu Y, Zou X, Zheng M, Tan B, Feng B, Dong T, He P, Zhao L, Zhao A, Xu LX, Zhang Y, Jia W: Distinct urinary metabolic profile of human colorectal cancer. J Proteome Res. 2012 Feb 3;11(2):1354-63. doi: 10.1021/pr201001a. Epub 2011 Dec 28.

pubmed_id:22148915

[8]:

reference_text:Ni Y, Xie G, Jia W: Metabonomics of human colorectal cancer: new approaches for early diagnosis and biomarker discovery. J Proteome Res. 2014 Sep 5;13(9):3857-70. doi: 10.1021/pr500443c. Epub 2014 Aug 14.

pubmed_id:25105552

[9]:

reference_text:Ikeda A, Nishiumi S, Shinohara M, Yoshie T, Hatano N, Okuno T, Bamba T, Fukusaki E, Takenawa T, Azuma T, Yoshida M: Serum metabolomics as a novel diagnostic approach for gastrointestinal cancer. Biomed Chromatogr. 2012 May;26(5):548-58. doi: 10.1002/bmc.1671. Epub 2011 Jul 20.

pubmed_id:21773981

[10]:

reference_text:Goedert JJ, Sampson JN, Moore SC, Xiao Q, Xiong X, Hayes RB, Ahn J, Shi J, Sinha R: Fecal metabolomics: assay performance and association with colorectal cancer. Carcinogenesis. 2014 Sep;35(9):2089-96. doi: 10.1093/carcin/bgu131. Epub 2014 Jul 18.

pubmed_id:25037050

[11]:

reference_text:Sinha R, Ahn J, Sampson JN, Shi J, Yu G, Xiong X, Hayes RB, Goedert JJ: Fecal Microbiota, Fecal Metabolome, and Colorectal Cancer Interrelations. PLoS One. 2016 Mar 25;11(3):e0152126. doi: 10.1371/journal.pone.0152126. eCollection 2016.

pubmed_id:27015276

[12]:

reference_text:Lin Y, Ma C, Liu C, Wang Z, Yang J, Liu X, Shen Z, Wu R: NMR-based fecal metabolomics fingerprinting as predictors of earlier diagnosis in patients with colorectal cancer. Oncotarget. 2016 May 17;7(20):29454-64. doi: 10.18632/oncotarget.8762.

pubmed_id:27107423

[13]:

reference_text:Brown DG, Rao S, Weir TL, O'Malia J, Bazan M, Brown RJ, Ryan EP: Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool. Cancer Metab. 2016 Jun 6;4:11. doi: 10.1186/s40170-016-0151-y. eCollection 2016.

pubmed_id:27275383

[14]:

reference_text:Wang X, Wang J, Rao B, Deng L: Gut flora profiling and fecal metabolite composition of colorectal cancer patients and healthy individuals. Exp Ther Med. 2017 Jun;13(6):2848-2854. doi: 10.3892/etm.2017.4367. Epub 2017 Apr 20.

pubmed_id:28587349

[15]:

reference_text:Silke Matysik, Caroline Ivanne Le Roy, Gerhard Liebisch, Sandrine Paule Claus. Metabolomics of fecal samples: A practical consideration. Trends in Food Science & Technology. Vol. 57, Part B, Nov. 2016, p.244-255: http://www.sciencedirect.com/science/article/pii/S0924224416301984

25:

name:Irritable bowel syndrome

omim_id:

[1]:

reference_text:Bearcroft CP, Perrett D, Farthing MJ: Postprandial plasma 5-hydroxytryptamine in diarrhoea predominant irritable bowel syndrome: a pilot study. Gut. 1998 Jan;42(1):42-6.

pubmed_id:9505884

[2]:

reference_text:Brydon WG, Nyhlin H, Eastwood MA, Merrick MV: Serum 7 alpha-hydroxy-4-cholesten-3-one and selenohomocholyltaurine (SeHCAT) whole body retention in the assessment of bile acid induced diarrhoea. Eur J Gastroenterol Hepatol. 1996 Feb;8(2):117-23.

pubmed_id:8723414

[3]:

reference_text:Ponnusamy K, Choi JN, Kim J, Lee SY, Lee CH: Microbial community and metabolomic comparison of irritable bowel syndrome faeces. J Med Microbiol. 2011 Jun;60(Pt 6):817-27. doi: 10.1099/jmm.0.028126-0. Epub 2011 Feb 17.

pubmed_id:21330412

[4]:

reference_text:Le Gall G, Noor SO, Ridgway K, Scovell L, Jamieson C, Johnson IT, Colquhoun IJ, Kemsley EK, Narbad A: Metabolomics of fecal extracts detects altered metabolic activity of gut microbiota in ulcerative colitis and irritable bowel syndrome. J Proteome Res. 2011 Sep 2;10(9):4208-18. doi: 10.1021/pr2003598. Epub 2011 Aug 8.

pubmed_id:21761941

[5]:

reference_text:Hong YS, Hong KS, Park MH, Ahn YT, Lee JH, Huh CS, Lee J, Kim IK, Hwang GS, Kim JS: Metabonomic understanding of probiotic effects in humans with irritable bowel syndrome. J Clin Gastroenterol. 2011 May-Jun;45(5):415-25. doi: 10.1097/MCG.0b013e318207f76c.

pubmed_id:21494186

[6]:

reference_text:Walton C, Fowler DP, Turner C, Jia W, Whitehead RN, Griffiths L, Dawson C, Waring RH, Ramsden DB, Cole JA, Cauchi M, Bessant C, Hunter JO: Analysis of volatile organic compounds of bacterial origin in chronic gastrointestinal diseases. Inflamm Bowel Dis. 2013 Sep;19(10):2069-78. doi: 10.1097/MIB.0b013e31829a91f6.

pubmed_id:23867873

[7]:

reference_text:Zeber-Lubecka N, Kulecka M, Ambrozkiewicz F, Paziewska A, Goryca K, Karczmarski J, Rubel T, Wojtowicz W, Mlynarz P, Marczak L, Tomecki R, Mikula M, Ostrowski J: Limited prolonged effects of rifaximin treatment on irritable bowel syndrome-related differences in the fecal microbiome and metabolome. Gut Microbes. 2016 Sep 2;7(5):397-413. doi: 10.1080/19490976.2016.1215805. Epub 2016 Jul 26.

pubmed_id:27662586

26:

name:Autism

omim_id:209850

[1]:

reference_text:Shaw W: Increased urinary excretion of a 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA), an abnormal phenylalanine metabolite of Clostridia spp. in the gastrointestinal tract, in urine samples from patients with autism and schizophrenia. Nutr Neurosci. 2010 Jun;13(3):135-43. doi: 10.1179/147683010X12611460763968.

pubmed_id:20423563

[2]:

reference_text:Narayan M, Srinath S, Anderson GM, Meundi DB: Cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid in autism. Biol Psychiatry. 1993 Apr 15-May 1;33(8-9):630-5.

pubmed_id:7687150

[3]:

reference_text:Jaeken J, Van den Berghe G: An infantile autistic syndrome characterised by the presence of succinylpurines in body fluids. Lancet. 1984 Nov 10;2(8411):1058-61.

pubmed_id:6150139

[4]:

reference_text:James SJ, Cutler P, Melnyk S, Jernigan S, Janak L, Gaylor DW, Neubrander JA: Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am J Clin Nutr. 2004 Dec;80(6):1611-7.

pubmed_id:15585776

[5]:

reference_text:Anderson GM, Ross DL, Klykylo W, Feibel FC, Cohen DJ: Cerebrospinal fluid indoleacetic acid in autistic subjects. J Autism Dev Disord. 1988 Jun;18(2):259-62.

pubmed_id:3410814

[6]:

reference_text:Kusaga A, Yamashita Y, Koeda T, Hiratani M, Kaneko M, Yamada S, Matsuishi T: Increased urine phenylethylamine after methylphenidate treatment in children with ADHD. Ann Neurol. 2002 Sep;52(3):372-4.

pubmed_id:12205654

[7]:

reference_text:De Angelis M, Piccolo M, Vannini L, Siragusa S, De Giacomo A, Serrazzanetti DI, Cristofori F, Guerzoni ME, Gobbetti M, Francavilla R: Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified. PLoS One. 2013 Oct 9;8(10):e76993. doi: 10.1371/journal.pone.0076993. eCollection 2013.

pubmed_id:24130822

27:

name:Diverticular disease

omim_id:

[1]:

reference_text:Brydon WG, Nyhlin H, Eastwood MA, Merrick MV: Serum 7 alpha-hydroxy-4-cholesten-3-one and selenohomocholyltaurine (SeHCAT) whole body retention in the assessment of bile acid induced diarrhoea. Eur J Gastroenterol Hepatol. 1996 Feb;8(2):117-23.

pubmed_id:8723414

[2]:

reference_text:Tursi A, Mastromarino P, Capobianco D, Elisei W, Miccheli A, Capuani G, Tomassini A, Campagna G, Picchio M, Giorgetti G, Fabiocchi F, Brandimarte G: Assessment of Fecal Microbiota and Fecal Metabolome in Symptomatic Uncomplicated Diverticular Disease of the Colon. J Clin Gastroenterol. 2016 Oct;50 Suppl 1:S9-S12. doi: 10.1097/MCG.0000000000000626.

pubmed_id:27622378

28:

name:Gout

omim_id:138900

[1]:

reference_text:Shao T, Shao L, Li H, Xie Z, He Z, Wen C: Combined Signature of the Fecal Microbiome and Metabolome in Patients with Gout. Front Microbiol. 2017 Feb 21;8:268. doi: 10.3389/fmicb.2017.00268. eCollection 2017.

pubmed_id:28270806

[2]:

reference_text:MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de)

pubmed_id:

29:

name:Rheumatoid arthritis

omim_id:180300

[1]:

reference_text:Laitinen O, Seppala E, Nissila M, Vapaatalo H: Plasma levels and urinary excretion of prostaglandins in patients with rheumatoid arthritis. Clin Rheumatol. 1983 Dec;2(4):401-6.

pubmed_id:6589104

[2]:

reference_text:Chiang EP, Smith DE, Selhub J, Dallal G, Wang YC, Roubenoff R: Inflammation causes tissue-specific depletion of vitamin B6. Arthritis Res Ther. 2005;7(6):R1254-62. Epub 2005 Sep 13.

pubmed_id:16277678

[3]:

reference_text:Jensen T, Klarlund M, Hansen M, Jensen KE, Skjodt H, Hyldstrup L: Connective tissue metabolism in patients with unclassified polyarthritis and early rheumatoid arthritis. Relationship to disease activity, bone mineral density, and radiographic outcome. J Rheumatol. 2004 Sep;31(9):1698-708.

pubmed_id:15338487

[4]:

reference_text:Chavis C, Fraissinet L, Chanez P, Thomas E, Bousquet J: A method for the measurement of plasma hydroxyeicosatetraenoic acid levels. Anal Biochem. 1999 Jun 15;271(1):105-8.

pubmed_id:10361015

[5]:

reference_text:Straub RH, Weidler C, Demmel B, Herrmann M, Kees F, Schmidt M, Scholmerich J, Schedel J: Renal clearance and daily excretion of cortisol and adrenal androgens in patients with rheumatoid arthritis and systemic lupus erythematosus. Ann Rheum Dis. 2004 Aug;63(8):961-8.

pubmed_id:15249323

[6]:

reference_text:Tie-juan ShaoZhi-xing HeZhi-jun XieHai-chang LiMei-jiao WangCheng-ping Wen. Characterization of ankylosing spondylitis and rheumatoid arthritis using 1H NMR-based metabolomics of human fecal extracts. Metabolomics. April 2016, 12:70: https://link.springer.com/article/10.1007/s11306-016-1000-2

30:

name:Perillyl alcohol administration for cancer treatment

omim_id:

[1]:

reference_text:Byun JA, Lee SH, Jung BH, Choi MH, Moon MH, Chung BC: Analysis of polyamines as carbamoyl derivatives in urine and serum by liquid chromatography-tandem mass spectrometry. Biomed Chromatogr. 2008 Jan;22(1):73-80.

pubmed_id:17668437

[2]:

reference_text:Zheng YF, Kong HW, Xiong JH, Lv S, Xu GW: Clinical significance and prognostic value of urinary nucleosides in breast cancer patients. Clin Biochem. 2005 Jan;38(1):24-30.

pubmed_id:15607313

[3]:

reference_text:Cauley JA, Zmuda JM, Danielson ME, Ljung BM, Bauer DC, Cummings SR, Kuller LH: Estrogen metabolites and the risk of breast cancer in older women. Epidemiology. 2003 Nov;14(6):740-4.

pubmed_id:14569192

[4]:

reference_text:Zhang Z, Chen H, Chan KK, Budd T, Ganapathi R: Gas chromatographic-mass spectrometric analysis of perillyl alcohol and metabolites in plasma. J Chromatogr B Biomed Sci Appl. 1999 May 14;728(1):85-95.

pubmed_id:10379660

[5]:

reference_text:Grace PB, Mistry NS, Carter MH, Leathem AJ, Teale P: High throughput quantification of phytoestrogens in human urine and serum using liquid chromatography/tandem mass spectrometry (LC-MS/MS). J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 15;853(1-2):138-46. Epub 2007 Mar 18.

pubmed_id:17403619

[6]:

reference_text:Silva CL, Passos M, Camara JS: Solid phase microextraction, mass spectrometry and metabolomic approaches for detection of potential urinary cancer biomarkers--a powerful strategy for breast cancer diagnosis. Talanta. 2012 Jan 30;89:360-8. doi: 10.1016/j.talanta.2011.12.041. Epub 2011 Dec 22.

pubmed_id:22284503

[7]:

reference_text:Sugimoto M, Wong DT, Hirayama A, Soga T, Tomita M: Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles. Metabolomics. 2010 Mar;6(1):78-95. Epub 2009 Sep 10.

pubmed_id:20300169

[8]:

reference_text:Lv W, Yang T: Identification of possible biomarkers for breast cancer from free fatty acid profiles determined by GC-MS and multivariate statistical analysis. Clin Biochem. 2012 Jan;45(1-2):127-33. doi: 10.1016/j.clinbiochem.2011.10.011. Epub 2011 Oct 26.

pubmed_id:22061338

[9]:

reference_text:Nam H, Chung BC, Kim Y, Lee K, Lee D: Combining tissue transcriptomics and urine metabolomics for breast cancer biomarker identification. Bioinformatics. 2009 Dec 1;25(23):3151-7. doi: 10.1093/bioinformatics/btp558. Epub 2009 Sep 25.

pubmed_id:19783829

[10]:

reference_text:Woo HM, Kim KM, Choi MH, Jung BH, Lee J, Kong G, Nam SJ, Kim S, Bai SW, Chung BC: Mass spectrometry based metabolomic approaches in urinary biomarker study of women's cancers. Clin Chim Acta. 2009 Feb;400(1-2):63-9. doi: 10.1016/j.cca.2008.10.014. Epub 2008 Oct 30.

pubmed_id:19010317

31:

name:Pancreatic cancer

omim_id:260350

[1]:

reference_text:Loser C, Folsch UR, Paprotny C, Creutzfeldt W: Polyamine concentrations in pancreatic tissue, serum, and urine of patients with pancreatic cancer. Pancreas. 1990 Mar;5(2):119-27.

pubmed_id:2315288

[2]:

reference_text:Sugimoto M, Wong DT, Hirayama A, Soga T, Tomita M: Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles. Metabolomics. 2010 Mar;6(1):78-95. Epub 2009 Sep 10.

pubmed_id:20300169

[3]:

reference_text:Zhang L, Jin H, Guo X, Yang Z, Zhao L, Tang S, Mo P, Wu K, Nie Y, Pan Y, Fan D: Distinguishing pancreatic cancer from chronic pancreatitis and healthy individuals by (1)H nuclear magnetic resonance-based metabonomic profiles. Clin Biochem. 2012 Sep;45(13-14):1064-9. doi: 10.1016/j.clinbiochem.2012.05.012. Epub 2012 May 19.

pubmed_id:22613268

[4]:

reference_text:OuYang D, Xu J, Huang H, Chen Z: Metabolomic profiling of serum from human pancreatic cancer patients using 1H NMR spectroscopy and principal component analysis. Appl Biochem Biotechnol. 2011 Sep;165(1):148-54. doi: 10.1007/s12010-011-9240-0. Epub 2011 Apr 20.

pubmed_id:21505807

[5]:

reference_text:Xie G, Lu L, Qiu Y, Ni Q, Zhang W, Gao YT, Risch HA, Yu H, Jia W: Plasma metabolite biomarkers for the detection of pancreatic cancer. J Proteome Res. 2015 Feb 6;14(2):1195-202. doi: 10.1021/pr501135f. Epub 2014 Dec 8.

pubmed_id:25429707

32:

name:Periodontal disease

omim_id:170650

[1]:

reference_text:Sugimoto M, Wong DT, Hirayama A, Soga T, Tomita M: Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles. Metabolomics. 2010 Mar;6(1):78-95. Epub 2009 Sep 10.

pubmed_id:20300169

33:

name:Alzheimer's disease

omim_id:104300

[1]:

reference_text:Fonteh AN, Harrington RJ, Tsai A, Liao P, Harrington MG: Free amino acid and dipeptide changes in the body fluids from Alzheimer's disease subjects. Amino Acids. 2007 Feb;32(2):213-24. Epub 2006 Oct 10.

pubmed_id:17031479

[2]:

reference_text:Selley ML, Close DR, Stern SE: The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer's disease. Neurobiol Aging. 2002 May-Jun;23(3):383-8.

pubmed_id:11959400

[3]:

reference_text:Shetty HU, Holloway HW, Schapiro MB: Cerebrospinal fluid and plasma distribution of myo-inositol and other polyols in Alzheimer disease. Clin Chem. 1996 Feb;42(2):298-302.

pubmed_id:8595727

[4]:

reference_text:Jia JP, Jia JM, Zhou WD, Xu M, Chu CB, Yan X, Sun YX: Differential acetylcholine and choline concentrations in the cerebrospinal fluid of patients with Alzheimer's disease and vascular dementia. Chin Med J (Engl). 2004 Aug;117(8):1161-4.

pubmed_id:15361288

[5]:

reference_text:Redjems-Bennani N, Jeandel C, Lefebvre E, Blain H, Vidailhet M, Gueant JL: Abnormal substrate levels that depend upon mitochondrial function in cerebrospinal fluid from Alzheimer patients. Gerontology. 1998;44(5):300-4.

pubmed_id:9693263

[6]:

reference_text:Walter A, Korth U, Hilgert M, Hartmann J, Weichel O, Hilgert M, Fassbender K, Schmitt A, Klein J: Glycerophosphocholine is elevated in cerebrospinal fluid of Alzheimer patients. Neurobiol Aging. 2004 Nov-Dec;25(10):1299-303.

pubmed_id:15465626

[7]:

reference_text:Leoni V, Masterman T, Mousavi FS, Wretlind B, Wahlund LO, Diczfalusy U, Hillert J, Bjorkhem I: Diagnostic use of cerebral and extracerebral oxysterols. Clin Chem Lab Med. 2004 Feb;42(2):186-91.

pubmed_id:15061359

[8]:

reference_text:Raskind MA, Peskind ER, Holmes C, Goldstein DS: Patterns of cerebrospinal fluid catechols support increased central noradrenergic responsiveness in aging and Alzheimer's disease. Biol Psychiatry. 1999 Sep 15;46(6):756-65.

pubmed_id:10494443

[9]:

reference_text:Lovell MA, Markesbery WR: Ratio of 8-hydroxyguanine in intact DNA to free 8-hydroxyguanine is increased in Alzheimer disease ventricular cerebrospinal fluid. Arch Neurol. 2001 Mar;58(3):392-6.

pubmed_id:11255442

[10]:

reference_text:Bar KJ, Franke S, Wenda B, Muller S, Kientsch-Engel R, Stein G, Sauer H: Pentosidine and N(epsilon)-(carboxymethyl)-lysine in Alzheimer's disease and vascular dementia. Neurobiol Aging. 2003 Mar-Apr;24(2):333-8.

pubmed_id:12498967

[11]:

reference_text:Serot JM, Barbe F, Arning E, Bottiglieri T, Franck P, Montagne P, Nicolas JP: Homocysteine and methylmalonic acid concentrations in cerebrospinal fluid: relation with age and Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2005 Nov;76(11):1585-7.

pubmed_id:16227558

[12]:

reference_text:Molina JA, Jimenez-Jimenez FJ, Aguilar MV, Meseguer I, Mateos-Vega CJ, Gonzalez-Munoz MJ, de Bustos F, Porta J, Orti-Pareja M, Zurdo M, Barrios E, Martinez-Para MC: Cerebrospinal fluid levels of transition metals in patients with Alzheimer's disease. J Neural Transm (Vienna). 1998;105(4-5):479-88.

pubmed_id:9720975

[13]:

reference_text:Molina JA, Jimenez-Jimenez FJ, Hernanz A, Fernandez-Vivancos E, Medina S, de Bustos F, Gomez-Escalonilla C, Sayed Y: Cerebrospinal fluid levels of thiamine in patients with Alzheimer's disease. J Neural Transm (Vienna). 2002 Jul;109(7-8):1035-44.

pubmed_id:12111441

[14]:

reference_text:Bocca B, Forte G, Petrucci F, Pino A, Marchione F, Bomboi G, Senofonte O, Giubilei F, Alimonti A: Monitoring of chemical elements and oxidative damage in patients affected by Alzheimer's disease. Ann Ist Super Sanita. 2005;41(2):197-203.

pubmed_id:16244393

[15]:

reference_text:Kristensen MO, Gulmann NC, Christensen JE, Ostergaard K, Rasmussen K: Serum cobalamin and methylmalonic acid in Alzheimer dementia. Acta Neurol Scand. 1993 Jun;87(6):475-81.

pubmed_id:8356878

[16]:

reference_text:Abe T, Tohgi H, Isobe C, Murata T, Sato C: Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease. J Neurosci Res. 2002 Nov 1;70(3):447-50.

pubmed_id:12391605

[17]:

reference_text:Reichman ME, Judd JT, Longcope C, Schatzkin A, Clevidence BA, Nair PP, Campbell WS, Taylor PR: Effects of alcohol consumption on plasma and urinary hormone concentrations in premenopausal women. J Natl Cancer Inst. 1993 May 5;85(9):722-7.

pubmed_id:8478958

[18]:

reference_text:Hozumi I, Hasegawa T, Honda A, Ozawa K, Hayashi Y, Hashimoto K, Yamada M, Koumura A, Sakurai T, Kimura A, Tanaka Y, Satoh M, Inuzuka T: Patterns of levels of biological metals in CSF differ among neurodegenerative diseases. J Neurol Sci. 2011 Apr 15;303(1-2):95-9. doi: 10.1016/j.jns.2011.01.003. Epub 2011 Feb 2.

pubmed_id:21292280

[19]:

reference_text:Motawaj M, Peoc'h K, Callebert J, Arrang JM: CSF levels of the histamine metabolite tele-methylhistamine are only slightly decreased in Alzheimer's disease. J Alzheimers Dis. 2010;22(3):861-71. doi: 10.3233/JAD-2010-100381.

pubmed_id:20858978

[20]:

reference_text:Smach MA, Jacob N, Golmard JL, Charfeddine B, Lammouchi T, Ben Othman L, Dridi H, Bennamou S, Limem K: Folate and homocysteine in the cerebrospinal fluid of patients with Alzheimer's disease or dementia: a case control study. Eur Neurol. 2011;65(5):270-8. doi: 10.1159/000326301. Epub 2011 Apr 8.

pubmed_id:21474939

[21]:

reference_text:Linnebank M, Popp J, Smulders Y, Smith D, Semmler A, Farkas M, Kulic L, Cvetanovska G, Blom H, Stoffel-Wagner B, Kolsch H, Weller M, Jessen F: S-adenosylmethionine is decreased in the cerebrospinal fluid of patients with Alzheimer's disease. Neurodegener Dis. 2010;7(6):373-8. doi: 10.1159/000309657. Epub 2010 Jun 3.

pubmed_id:20523031

[22]:

reference_text:Rosler N, Wichart I, Jellinger KA: Clinical significance of neurobiochemical profiles in the lumbar cerebrospinal fluid of Alzheimer's disease patients. J Neural Transm (Vienna). 2001;108(2):231-46.

pubmed_id:11314776

[23]:

reference_text:Sunderland T, Berrettini WH, Molchan SE, Lawlor BA, Martinez RA, Vitiello B, Tariot PN, Cohen RM: Reduced cerebrospinal fluid dynorphin A1-8 in Alzheimer's disease. Biol Psychiatry. 1991 Jul 1;30(1):81-7.

pubmed_id:1716470

[24]:

reference_text:Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6.

pubmed_id:23857558

34:

name:Frontotemporal dementia

omim_id:600274

[1]:

reference_text:Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6.

pubmed_id:23857558

35:

name:Lewy body disease

omim_id:

[1]:

reference_text:Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6.

pubmed_id:23857558

36:

name:Temporomandibular joint disorder

omim_id:

[1]:

reference_text:Sugimoto et al. (2013) Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles.

pubmed_id:

37:

name:Paraquat poisoning

omim_id:

[1]:

reference_text:Bairaktari E, Katopodis K, Siamopoulos KC, Tsolas O: Paraquat-induced renal injury studied by 1H nuclear magnetic resonance spectroscopy of urine. Clin Chem. 1998 Jun;44(6 Pt 1):1256-61.

pubmed_id:9625050

38:

name:Lung Cancer

omim_id:211980

[1]:

reference_text:Stretch C, Eastman T, Mandal R, Eisner R, Wishart DS, Mourtzakis M, Prado CM, Damaraju S, Ball RO, Greiner R, Baracos VE: Prediction of skeletal muscle and fat mass in patients with advanced cancer using a metabolomic approach. J Nutr. 2012 Jan;142(1):14-21. doi: 10.3945/jn.111.147751. Epub 2011 Dec 7.

pubmed_id:22157537

[2]:

reference_text:Wishart DS, Knox C, Guo AC, Eisner R, Young N, Gautam B, Hau DD, Psychogios N, Dong E, Bouatra S, Mandal R, Sinelnikov I, Xia J, Jia L, Cruz JA, Lim E, Sobsey CA, Shrivastava S, Huang P, Liu P, Fang L, Peng J, Fradette R, Cheng D, Tzur D, Clements M, Lewis A, De Souza A, Zuniga A, Dawe M, Xiong Y, Clive D, Greiner R, Nazyrova A, Shaykhutdinov R, Li L, Vogel HJ, Forsythe I: HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 Jan;37(Database issue):D603-10. doi: 10.1093/nar/gkn810. Epub 2008 Oct 25.

pubmed_id:18953024

[3]:

reference_text:Chen Y, Ma Z, Min L, Li H, Wang B, Zhong J, Dai L: Biomarker identification and pathway analysis by serum metabolomics of lung cancer. Biomed Res Int. 2015;2015:183624. doi: 10.1155/2015/183624. Epub 2015 Apr 16.

pubmed_id:25961003

39:

name:Eosinophilic esophagitis

omim_id:610247

[1]:

reference_text:Mordechai, Hien, and David S. Wishart

pubmed_id:

40:

name:Amish lethal microcephaly

omim_id:607196

[1]:

reference_text:Kelley RI, Robinson D, Puffenberger EG, Strauss KA, Morton DH: Amish lethal microcephaly: a new metabolic disorder with severe congenital microcephaly and 2-ketoglutaric aciduria. Am J Med Genet. 2002 Nov 1;112(4):318-26. doi: 10.1002/ajmg.10529.

pubmed_id:12376931

KEGG数据库编号
C00041
DrugBank数据库编号
DB00160
foodb数据库编号
FDB000556
ChemSpider数据库编号
5735
公共化学化合物编号
5950
PDB数据库编号
生物利益的化学实体数据库编号
16977
knapsack数据库编号
C00001332
维基百科编号
Alanine
代谢途径的数据库编号
L-ALPHA-ALANINE
苯酚资源管理器化合物数据库编号
比格数据库编号
33629
梅林编号
虚拟机身份证编号
ALA_L
fbonto数据库编号
综合参考
Chibata I; Kakimoto T; Kato J Enzymatic production of L-alanine by Pseudomonas dacunhae. Applied microbiology (1965), 13(5), 638-45.
一般参考
1:

protein_accession:HMDBP00248

name:4-aminobutyrate aminotransferase, mitochondrial

uniprot_id:P80404

gene_name:ABAT

protein_type:Enzyme

2:

protein_accession:HMDBP00325

name:Kynureninase

uniprot_id:Q16719

gene_name:KYNU

protein_type:Unknown

3:

protein_accession:HMDBP00396

name:Alanine--glyoxylate aminotransferase 2, mitochondrial

uniprot_id:Q9BYV1

gene_name:AGXT2

protein_type:Enzyme

4:

protein_accession:HMDBP00625

name:Alanine--tRNA ligase, cytoplasmic

uniprot_id:P49588

gene_name:AARS

protein_type:Enzyme

5:

protein_accession:HMDBP00789

name:Serine--pyruvate aminotransferase

uniprot_id:P21549

gene_name:AGXT

protein_type:Unknown

6:

protein_accession:HMDBP00850

name:Alanine aminotransferase 1

uniprot_id:P24298

gene_name:GPT

protein_type:Enzyme

7:

protein_accession:HMDBP02049

name:Peptidoglycan recognition protein 1

uniprot_id:O75594

gene_name:PGLYRP1

protein_type:Enzyme

8:

protein_accession:HMDBP02392

name:Large neutral amino acids transporter small subunit 2

uniprot_id:Q9UHI5

gene_name:SLC7A8

protein_type:Transporter

9:

protein_accession:HMDBP02513

name:Cysteine desulfurase, mitochondrial

uniprot_id:Q9Y697

gene_name:NFS1

protein_type:Unknown

10:

protein_accession:HMDBP03036

name:Sodium-coupled neutral amino acid transporter 3

uniprot_id:Q99624

gene_name:SLC38A3

protein_type:Transporter

11:

protein_accession:HMDBP03110

name:Neutral amino acid transporter A

uniprot_id:P43007

gene_name:SLC1A4

protein_type:Unknown

12:

protein_accession:HMDBP03592

name:Proton-coupled amino acid transporter 1

uniprot_id:Q7Z2H8

gene_name:SLC36A1

protein_type:Transporter

13:

protein_accession:HMDBP03670

name:Alanine aminotransferase 2

uniprot_id:Q8TD30

gene_name:GPT2

protein_type:Enzyme

14:

protein_accession:HMDBP04824

name:Selenocysteine lyase

uniprot_id:Q96I15

gene_name:SCLY

protein_type:Enzyme

15:

protein_accession:HMDBP05340

name:Monocarboxylate transporter 10

uniprot_id:Q8TF71

gene_name:SLC16A10

protein_type:Transporter

16:

protein_accession:HMDBP08966

name:5-phosphohydroxy-L-lysine phospho-lyase

uniprot_id:Q8IUZ5

gene_name:AGXT2L2

protein_type:Enzyme

17:

protein_accession:HMDBP08969

name:Molybdenum cofactor sulfurase

uniprot_id:Q96EN8

gene_name:MOCOS

protein_type:Enzyme

18:

protein_accession:HMDBP09366

name:Peptidoglycan recognition protein 3

uniprot_id:Q96LB9

gene_name:PGLYRP3

protein_type:Enzyme

19:

protein_accession:HMDBP09367

name:Peptidoglycan recognition protein 4

uniprot_id:Q96LB8

gene_name:PGLYRP4

protein_type:Enzyme

20:

protein_accession:HMDBP10671

name:Alanine--tRNA ligase, mitochondrial

uniprot_id:Q5JTZ9

gene_name:AARS2

protein_type:Enzyme

21:

protein_accession:HMDBP11877

name:N-acetylmuramoyl-L-alanine amidase

uniprot_id:Q96PD5

gene_name:PGLYRP2

protein_type:Unknown

蛋白质结合
1:

reference_text:Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762.

pubmed_id:19212411

2:

reference_text:Silwood CJ, Lynch E, Claxson AW, Grootveld MC: 1H and (13)C NMR spectroscopic analysis of human saliva. J Dent Res. 2002 Jun;81(6):422-7.

pubmed_id:12097436

3:

reference_text:Nicholson JK, O'Flynn MP, Sadler PJ, Macleod AF, Juul SM, Sonksen PH: Proton-nuclear-magnetic-resonance studies of serum, plasma and urine from fasting normal and diabetic subjects. Biochem J. 1984 Jan 15;217(2):365-75.

pubmed_id:6696735

4:

reference_text:Bairaktari E, Katopodis K, Siamopoulos KC, Tsolas O: Paraquat-induced renal injury studied by 1H nuclear magnetic resonance spectroscopy of urine. Clin Chem. 1998 Jun;44(6 Pt 1):1256-61.

pubmed_id:9625050

5:

reference_text:Wevers RA, Engelke U, Wendel U, de Jong JG, Gabreels FJ, Heerschap A: Standardized method for high-resolution 1H-NMR of cerebrospinal fluid. Clin Chem. 1995 May;41(5):744-51.

pubmed_id:7729054

6:

reference_text:Hagenfeldt L, Bjerkenstedt L, Edman G, Sedvall G, Wiesel FA: Amino acids in plasma and CSF and monoamine metabolites in CSF: interrelationship in healthy subjects. J Neurochem. 1984 Mar;42(3):833-7.

pubmed_id:6198473

7:

reference_text:Peng CT, Wu KH, Lan SJ, Tsai JJ, Tsai FJ, Tsai CH: Amino acid concentrations in cerebrospinal fluid in children with acute lymphoblastic leukemia undergoing chemotherapy. Eur J Cancer. 2005 May;41(8):1158-63. Epub 2005 Apr 14.

pubmed_id:15911239

8:

reference_text:Cynober LA: Plasma amino acid levels with a note on membrane transport: characteristics, regulation, and metabolic significance. Nutrition. 2002 Sep;18(9):761-6.

pubmed_id:12297216

9:

reference_text:Rainesalo S, Keranen T, Palmio J, Peltola J, Oja SS, Saransaari P: Plasma and cerebrospinal fluid amino acids in epileptic patients. Neurochem Res. 2004 Jan;29(1):319-24.

pubmed_id:14992292

10:

reference_text:Klassen P, Furst P, Schulz C, Mazariegos M, Solomons NW: Plasma free amino acid concentrations in healthy Guatemalan adults and in patients with classic dengue. Am J Clin Nutr. 2001 Mar;73(3):647-52.

pubmed_id:11237944

11:

reference_text:Iioka H, Hisanaga H, Moriyama IS, Akada S, Shimamoto T, Yamada Y, Ichijo M: Characterization of human placental activity for transport of L-alanine, using brush border (microvillous) membrane vesicles. Placenta. 1992 Mar-Apr;13(2):179-90.

pubmed_id:1631030

12:

reference_text:Saklatvala J: Hydrolysis of the elastase substrate succinyltrialanine nitroanilide by a metal-dependent enzyme in rheumatoid synovial fluid. J Clin Invest. 1977 May;59(5):794-801.

pubmed_id:16038

13:

reference_text:Stahl A, Frick A, Imler M, Schlienger JL: Semiautomated enzymic microassay for plasma L-alanine. Enzyme. 1979;24(5):294-301.

pubmed_id:41707

14:

reference_text:Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043.

pubmed_id:32033212

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