版本
5.0
创建日期
2005-11-16 15:48:42 UTC
更新日期
2021-09-07 16:24:05 UTC
登录号
HMDB0000157
地位
quantified
二级访问
HMDB00157

名称
Hypoxanthine
描述
Hypoxanthine, also known as purine-6-ol or Hyp, belongs to the class of organic compounds known as purines. Purines are a bicyclic aromatic compound made up of a pyrimidine ring fused to an imidazole ring. Hypoxanthine is also classified as an oxopurine, Hypoxanthine is a naturally occurring purine derivative and a reaction intermediate in the metabolism of adenosine and in the formation of nucleic acids by the nucleotide salvage pathway. Hypoxanthine exists in all living species, ranging from bacteria to plants to humans. Hypoxanthine has been detected, but not quantified in, several different foods, such as radish (var.), mountain yams, welsh onions, greenthread tea, and common beets. Hypoxanthine is occasionally found as a constituent of nucleic acids, where it is present in the anticodon of tRNA in the form of its nucleoside inosine. Biologically, hypoxanthine can be formed a number of ways. For instance, it is one of the products of the action of xanthine oxidase on xanthine. However, more frequently xanthine is formed from oxidation of hypoxanthine by xanthine oxidoreductase. The enzyme hypoxanthine-guanine phosphoribosyltransferase converts hypoxanthine into IMP in the nucleotide salvage pathway. Hypoxanthine is also a spontaneous deamination product of adenine. Under normal circumstances hypoxanthine is readily converted to uric acid. In this process, hypoxanthine is first oxidized to xanthine, which is further oxidized to uric acid by xanthine oxidase. Molecular oxygen, the oxidant in both reactions, is reduced to H2O2 and other reactive oxygen species. In humans, uric acid is the final product of purine degradation and is excreted in the urine. Within humans, hypoxanthine participates in a number of other enzymatic reactions. In particular, hypoxanthine and ribose 1-phosphate can be biosynthesized from inosine through its interaction with the enzyme purine nucleoside phosphorylase. Hypoxanthine is also involved in the metabolic disorder called the purine nucleoside phosphorylase deficiency. Purine nucleoside phosphorylase (PNP) deficiency is a disorder of the immune system (primary immunodeficiency) characterized by recurrent infections, neurologic symptoms, and autoimmune disorders. PNP deficiency causes a shortage of white blood cells, called T-cells, that help fight infection. Affected individuals develop neurologic symptoms, such as stiff or rigid muscles (spasticity), uncoordinated movements (ataxia), developmental delay, and intellectual disability. PNP deficiency is associated with an increased risk to develop autoimmune disorders, such as autoimmune hemolytic anemia, idiopathic thrombocytopenic purpura (ITP), autoimmune neutropenia, thyroiditis, and lupus.
同义词
1:6(1H)-Purinone

2:6-Oxopurine

3:9H-Purin-6(1H)-one

4:Hyp

5:Purin-6(1H)-one

6:Purine-6-ol

7:1,7-Dihydro-6H-purin-6-one

8:1,7-Dihydro-6H-purine-6-one

9:1H,7H-Hypoxanthine

10:3H-Purin-6-ol

11:4-Hydroxy-1H-purine

12:6-Hydroxy-1H-purine

13:6-Hydroxypurine

14:7H-Purin-6-ol

15:9H-Purin-6-ol

16:Hypoxanthine enol

17:Purin-6(3H)-one

18:Purin-6-ol

19:Sarcine

20:Sarkin

21:Sarkine

化学式
C5H4N4O
平均分子量
136.1115
等位分子量
136.03851077
化学名称
7H-purin-6-ol
传统名称
6-hydroxypurine
CAS 登记号
68-94-0
代谢物结构字符串
OC1=NC=NC2=C1NC=N2
inchi标识符
InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
印记键
FDGQSTZJBFJUBT-UHFFFAOYSA-N
分类学
description: belongs to the class of organic compounds known as hypoxanthines. Hypoxanthines are compounds containing the purine derivative 1H-purin-6(9H)-one. Purine is a bicyclic aromatic compound made up of a pyrimidine ring fused to an imidazole ring.

description:Hypoxanthines

kingdom:Organic compounds

super_class:Organoheterocyclic compounds

class:Imidazopyrimidines

sub_class:Purines and purine derivatives

molecular_framework:Aromatic heteropolycyclic compounds

1:6-oxopurines

2:Azacyclic compounds

3:Heteroaromatic compounds

4:Hydrocarbon derivatives

5:Imidazoles

6:Organic oxides

7:Organonitrogen compounds

8:Organooxygen compounds

9:Organopnictogen compounds

10:Pyrimidones

11:Vinylogous amides

12:6-oxopurine

13:Aromatic heteropolycyclic compound

14:Azacycle

15:Azole

16:Heteroaromatic compound

17:Hydrocarbon derivative

18:Hypoxanthine

19:Imidazole

20:Organic nitrogen compound

21:Organic oxide

22:Organic oxygen compound

23:Organonitrogen compound

24:Organooxygen compound

25:Organopnictogen compound

26:Pyrimidine

27:Pyrimidone

28:Vinylogous amide

29:Purine alkaloids

30:a purine base

31:a purine-related compound

32:nucleobase analogue

33:oxopurine

34:purine nucleobase

本体论
term:Physiological effect

definition:The effect on an organism physiology, resulting from its exposure to a chemical.

parent_id:

level:1

type:parent

term:Health effect

definition:A health condition or observation associated with a stimuli or with a biological activity of a chemical.

parent_id:7693

*level:2

type:parent

term:Observation

definition:A short term health effect which reflects the reponse of the body to stimuli or is a symptom of a disease or condition; also includes health status which reflects stage in life.

parent_id:7694

**level:3

type:parent

term:Bleeding

definition:

parent_id:7717

***level:4

type:child

term:Attachment loss

definition:

parent_id:7717

***level:4

type:child

term:Periodontal Probing Depth

definition:

parent_id:7717

***level:4

type:child

term:Investigations

definition:The act or process of a systematic and thorough examination; research, study; the process of inquiring into or following up, intended to develop facts. (nci).

parent_id:7717

***level:4

type:parent

term:Health condition

definition:A health effect that consists on short or long-term disease, condition, disorder, syndrome or constant abnormality.

parent_id:7694

**level:3

type:parent

term:Degenerative disc disease

definition:A bone deterioration disease that has material basis in gradual dehydration and tears located in intervertebral disc. (do).

parent_id:7695

***level:4

type:child

synonym:Ddd

term:Lesch-nyhan syndrome

definition:

parent_id:7695

***level:4

type:child

synonym:Lns

synonym:Kelley-seegmiller syndrome

synonym:Nyhan's syndrome

synonym:Hypoxanthin guanine phosphoribosyl transferase

term:Urolithiasis

definition:

parent_id:7695

***level:4

type:child

synonym:Urinary bladder calculi

synonym:Bladder calculi

synonym:Bladder stones

synonym:Cystoliths

term:Coma

definition:A state of profound unconsciousness associated with markedly depressed cerebral activity. Causes include central nervous system damage, intoxication, and metabolic abnormalities.

parent_id:7695

***level:4

type:child

term:Xanthinuria

definition:A purine-pyrimidine metabolic disorder characterized by deficiency of xanthine oxidase, resulting in excretion of large amounts of xanthine in the urine and the formation of xanthine stones. (do).

parent_id:7695

***level:4

type:child

synonym:Xanthinuria

synonym:Xanthine dehydrogenase deficiency

synonym:Xdh deficiency

synonym:Xanthine oxidase deficiency

term:Psychosis

definition:A mental disorder characterized by personality change, impaired functioning, and loss of touch with reality. (NCI)

parent_id:7695

***level:4

type:child

term:Uremia

definition:A disorder characterized by accummulation of solutes in the blood of people with chronic kidney disease. (do).

parent_id:7695

***level:4

type:child

synonym:Uraemia

term:Renal and urinary disorders

definition:Any disorder that affects the kidneys and the urologic system.

parent_id:7695

***level:4

type:parent

term:Psychiatric disorders

definition:A group of disorders characterized by behavioral and/or psychological abnormalities, often accompanied by physical symptoms. the symptoms may cause clinically significant distress or impairment in social and occupational areas of functioning. representative examples include anxiety disorders, cognitive disorders, mood disorders and schizophrenia. (nci).

parent_id:7695

***level:4

type:parent

term:Gastrointestinal disorders

definition:Any disorder (non-neoplastic or neoplastic) that affects the gastrointestinal tract.

parent_id:7695

***level:4

type:parent

term:Cancer

definition:A group of disorders characterized by the presense of malignant neoplasm.

parent_id:7695

***level:4

type:parent

term:Nervous system disorders

definition:Any disorder (non-neoplastic or neoplastic) that affects the brain, spinal cord, or peripheral nerves.

parent_id:7695

***level:4

type:parent

term:Disposition

definition:A concept that describes the origin of a chemical, its location within an organism, or its route of exposure.

parent_id:

level:1

type:parent

term:Route of exposure

definition:A mean by which a chemical agent comes in contact with an organism, either under intended or unintended circumstances.

parent_id:7724

*level:2

type:parent

term:Parenteral

definition:Chemical exposure via the a route other than the alimentary canal.

parent_id:7743

**level:3

type:parent

term:Dermal

definition:Chemical exposure by contact with the dermis or a cuticle or cornified region of the epidermis.

parent_id:7745

***level:4

type:child

synonym:Topical

synonym:Skin contact

synonym:Cutaneous (related but nor necessarily exact synonym)

synonym:Transdermal

term:Enteral

definition:Chemical exposure via the alimentary canal (mouth to anus).

parent_id:7743

**level:3

type:parent

term:Ingestion

definition:Chemical exposure facilitated by entry through the mouth.

parent_id:7744

***level:4

type:child

synonym:Digestion

term:Source

definition:Natural or synthetic origin of a chemical.

parent_id:7724

*level:2

type:parent

term:Endogenous

definition:

parent_id:7735

**level:3

type:child

term:Food

definition:

parent_id:7735

**level:3

type:child

term:Biological

definition:A living organism (species or a higher taxonomy rank), in which a chemical can be found.

parent_id:7735

**level:3

type:parent

term:Plant

definition:A living organism belonging to the kingdom plantea. typically, it grows in a permanent site, absorbs water and inorganic substances through its roots, and synthesizes nutrients in its leaves by photosynthesis using the green pigment chlorophyll. examples incude trees, shrubs, herbs, grasses, ferns, and mosses.

parent_id:7736

***level:4

type:parent

synonym:Flora

term:Animal

definition:A living organism belonging to the kingdom animalia. it feeds on organic matter, typically having specialized sense organs and nervous system and able to respond rapidly to stimuli.

parent_id:7736

***level:4

type:child

synonym:Fauna

term:Biological location

definition:The physiological origin within an organism, including anatomical compnents, biofluids and excreta.

parent_id:7724

*level:2

type:parent

term:Organ and components

definition:An anatomical organizational level including multiple tissues or substructures, which enables a common biological function.

parent_id:7725

**level:3

type:parent

term:Intestine

definition:The portion of the gastrointestinal tract that includes the small and large intestines.

parent_id:7727

***level:4

type:child

term:Testicle

definition:Either of the paired male reproductive glands that produce the male germ cells and the male hormones. (nci).

parent_id:7727

***level:4

type:child

synonym:Testes

synonym:Testis

term:Spleen

definition:An abdominal organ that is part of the hematopoietic and immune systems. it is composed of the white pulp and the red pulp and is surrounded by a capsule. (nci).

parent_id:7727

***level:4

type:child

term:Liver

definition:An abdominal organ that has variable lobation which are composed mainly of hepatic lobules. (nci).

parent_id:7727

***level:4

type:child

term:Prostate

definition:The male reproductive accessory gland that produces prostatic fluid and is located adjacent to or around the urethra distal to the urinary bladder in mammals. (nci).

parent_id:7727

***level:4

type:child

synonym:Prostate gland

term:Kidney

definition:The organs of the urinary tract located in the retroperitoneal cavity adjacent to the spine and composed of the renal cortex and the renal medulla. (nci).

parent_id:7727

***level:4

type:child

synonym:Kidneys

term:Tissue and substructures

definition:An anatomical organizational level including multiple cells yet not comprising a complete organ .

parent_id:7725

**level:3

type:parent

term:Placenta

definition:An organ present in some vertebrates during embryonic gestation that surrounds the fetus and provides it with nutrients and oxygen, facilitates gas and waste exchange between the fetus and mother, and provides parasitic cloaking from the mother's immune system by excretion of neurokinin b. (nci).

parent_id:7729

***level:4

type:child

term:Epidermis

definition:The epithelial portion of the skin (cutis). it consists of the following layers: stratum corneum (horny layer), stratum granulosum (granular layer), stratum spinosum (prickle cell layer), and stratum basale (basal cell layer). (nci).

parent_id:7729

***level:4

type:child

term:Adipose tissue

definition:A specialized form of connective tissue consisting primarily of adipocytes (fat cells), surrounded by a meshwork of collagen fibers. (NCI)

parent_id:7729

***level:4

type:child

synonym:Fat tissue

synonym:Body fat

synonym:Adipose

term:Skeletal muscle

definition:Striated muscles that are under voluntary control of the organism. they are connected at either or both ends to a bone and are utilized for locomotion and other movements. (nci).

parent_id:7729

***level:4

type:child

synonym:Striated muscle

term:Muscle

definition:A fibrous soft tissue with the ability to contract to produce force and motion. (nci).

parent_id:7729

***level:4

type:child

term:Biofluid and excreta

definition:A liquid, semi-solid or solid material originating in the body.

parent_id:7725

**level:3

type:parent

term:Urine

definition:Excretion in liquid state processed by the kidney.

parent_id:7731

***level:4

type:child

term:Feces

definition:The material discharged from the bowel during defecation. It consists of undigested food, intestinal mucus, epithelial cells, and bacteria.

parent_id:7731

***level:4

type:child

synonym:Fecal

synonym:Stool

synonym:Faecal

synonym:Faeces

term:Blood

definition:A liquid tissue with the primary function of transporting oxygen and carbon dioxide (nci). it supplies the tissues with nutrients, removes waste products, and contains various components of the immune system defending the body against infection.

parent_id:7731

***level:4

type:child

term:Breast milk

definition:Portion of secreted substance produced by the mammary gland.

parent_id:7731

***level:4

type:child

term:Saliva

definition:The watery fluid in the mouth made by the salivary glands. saliva moistens food to help digestion and it helps protect the mouth against infections. (nci).

parent_id:7731

***level:4

type:child

term:Cerebrospinal fluid

definition:The fluid that is contained within the brain ventricles, the subarachnoid space and the central canal of the spinal cord. (nci).

parent_id:7731

***level:4

type:child

synonym:Csf

term:Subcellular

definition:An anatomical organizational level including a component within a biological cell .

parent_id:7725

**level:3

type:parent

term:Cytoplasm

definition:The portion of the cell contained within the plasma membrane but excluding the nucleus.

parent_id:7730

***level:4

type:child

synonym:Cytoplasma

term:Lysosome

definition:В A sac-like compartment inside a cell that has enzymes that can break down cellular components that need to be destroyed. (NCI).

parent_id:7730

***level:4

type:child

term:Peroxisome

definition:A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. (Gene Ontology).

parent_id:7730

***level:4

type:child

synonym:Peroxisome vesicle

synonym:Peroxisomal

term:Cell and elements

definition:An anatomical organizational level comprising of a single cell (or a fragment in some exceptions). a cell is defined by its type or function. it is the smallest unit of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid.

parent_id:7725

**level:3

type:parent

term:Extracellular

definition:The space external to the outermost structure of a cell.

parent_id:7732

***level:4

type:child

synonym:Extracellular region

term:Element

definition:

parent_id:7732

***level:4

type:parent

term:Cell

definition:

parent_id:7732

***level:4

type:parent

term:Process

definition:Biological or chemical events, or a series thereof, leading to a known function or end-product.

parent_id:

level:1

type:parent

term:Naturally occurring process

definition:Naturally-occurring molecular events or a series thereof, leading to a known function or end-product.

parent_id:7659

*level:2

type:parent

term:Biological process

definition:Biological or chemical events or a series thereof, leading to a known function or end-product within an organism.

parent_id:7660

**level:3

type:parent

term:Biochemical pathway

definition:A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.

parent_id:7661

***level:4

type:parent

term:Role

definition:The purpose or function assumed by a chemical, either naturally or as intended by humans .

parent_id:

level:1

type:parent

term:Industrial application

definition:The assumed function of a chemical utilized by human.

parent_id:7671

*level:2

type:parent

term:Pharmaceutical industry

definition:A pharmacologic activity for which a chemical substance is utilized owing to its biological role.

parent_id:7678

**level:3

type:parent

term:Pharmaceutical

definition:

parent_id:7679

***level:4

type:child

term:Biological role

definition:The biological function of a chemical. the biological role answers the question how a chemical is involved in molecular processes in an organism. this can include biochemical effects of non-endogenous chemicals, which are also assigned an industrial application such as pharmaceuticals. the biological role is limited to cellular levls, and will not include role at system process level, such as a chemical which has a role in a disease.

parent_id:7671

*level:2

type:parent

term:Drug metabolite

definition:

parent_id:7672

**level:3

type:child

term:Waste product

definition:A chemical that is generated in a metabolic process and is destined to be excreted from the body. It commonly consists of water, nitrogenous compounds or carbon dioxide and can be a metabolic byproduct or a degradation product (such as urobilin metabolised from bilirubin which is a degradation product of hemoglobin).

parent_id:7672

**level:3

type:child

term:Metabolite

definition:A chemical substance produced during metabolism process, as an intermediate or end-product.

parent_id:7672

**level:3

type:child

状态
Solid
实验性质
1:

kind:water_solubility

value:0.7 mg/mL

source:YALKOWSKY,SH & DANNENFELSER,RM (1992)

2:

kind:logp

value:-1.11

source:HANSCH,C ET AL. (1995)

3:

kind:melting_point

value:150 °C

source:

预测性质
1:

kind:logp

value:-0.55

source:ALOGPS

2:

kind:logs

value:-1.02

source:ALOGPS

3:

kind:solubility

value:13 g/L

source:ALOGPS

4:

kind:logp

value:-0.048

source:ChemAxon

5:

kind:pka_strongest_acidic

value:8.72

source:ChemAxon

6:

kind:pka_strongest_basic

value:1.73

source:ChemAxon

7:

kind:iupac

value:7H-purin-6-ol

source:ChemAxon

8:

kind:average_mass

value:136.1115

source:ChemAxon

9:

kind:mono_mass

value:136.03851077

source:ChemAxon

10:

kind:smiles

value:OC1=NC=NC2=C1NC=N2

source:ChemAxon

11:

kind:formula

value:C5H4N4O

source:ChemAxon

12:

kind:inchi

value:InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)

source:ChemAxon

13:

kind:inchikey

value:FDGQSTZJBFJUBT-UHFFFAOYSA-N

source:ChemAxon

14:

kind:polar_surface_area

value:74.69

source:ChemAxon

15:

kind:refractivity

value:35.5

source:ChemAxon

16:

kind:polarizability

value:11.82

source:ChemAxon

17:

kind:rotatable_bond_count

value:0

source:ChemAxon

18:

kind:acceptor_count

value:4

source:ChemAxon

19:

kind:donor_count

value:2

source:ChemAxon

20:

kind:physiological_charge

value:0

source:ChemAxon

21:

kind:formal_charge

value:0

source:ChemAxon

22:

kind:number_of_rings

value:2

source:ChemAxon

23:

kind:bioavailability

value:Yes

source:ChemAxon

24:

kind:rule_of_five

value:Yes

source:ChemAxon

25:

kind:ghose_filter

value:No

source:ChemAxon

26:

kind:veber_rule

value:No

source:ChemAxon

27:

kind:mddr_like_rule

value:No

source:ChemAxon

1:

type:Specdb::NmrTwoD

spectrum_id:973

2:

type:Specdb::NmrTwoD

spectrum_id:1175

3:

type:Specdb::EiMs

spectrum_id:325

4:

type:Specdb::MsMs

spectrum_id:3139

5:

type:Specdb::MsMs

spectrum_id:3140

6:

type:Specdb::MsMs

spectrum_id:3141

7:

type:Specdb::MsMs

spectrum_id:3142

8:

type:Specdb::MsMs

spectrum_id:3143

9:

type:Specdb::MsMs

spectrum_id:3144

10:

type:Specdb::MsMs

spectrum_id:3145

11:

type:Specdb::MsMs

spectrum_id:3146

12:

type:Specdb::MsMs

spectrum_id:437791

13:

type:Specdb::MsMs

spectrum_id:437792

14:

type:Specdb::MsMs

spectrum_id:437793

15:

type:Specdb::MsMs

spectrum_id:437794

16:

type:Specdb::MsMs

spectrum_id:437795

17:

type:Specdb::MsMs

spectrum_id:438800

18:

type:Specdb::MsMs

spectrum_id:438801

19:

type:Specdb::MsMs

spectrum_id:440044

20:

type:Specdb::MsMs

spectrum_id:2228050

21:

type:Specdb::MsMs

spectrum_id:2229030

22:

type:Specdb::MsMs

spectrum_id:2229093

23:

type:Specdb::MsMs

spectrum_id:2230336

24:

type:Specdb::MsMs

spectrum_id:2230407

25:

type:Specdb::MsMs

spectrum_id:2231426

26:

type:Specdb::MsMs

spectrum_id:2232796

27:

type:Specdb::MsMs

spectrum_id:2233750

28:

type:Specdb::MsMs

spectrum_id:2235172

29:

type:Specdb::CMs

spectrum_id:380

30:

type:Specdb::CMs

spectrum_id:381

31:

type:Specdb::CMs

spectrum_id:382

32:

type:Specdb::CMs

spectrum_id:1487

33:

type:Specdb::CMs

spectrum_id:2948

34:

type:Specdb::CMs

spectrum_id:29560

35:

type:Specdb::CMs

spectrum_id:30193

36:

type:Specdb::CMs

spectrum_id:30574

37:

type:Specdb::CMs

spectrum_id:30876

38:

type:Specdb::CMs

spectrum_id:31029

39:

type:Specdb::CMs

spectrum_id:31967

40:

type:Specdb::CMs

spectrum_id:31968

41:

type:Specdb::CMs

spectrum_id:37327

42:

type:Specdb::CMs

spectrum_id:169563

43:

type:Specdb::NmrOneD

spectrum_id:1116

44:

type:Specdb::NmrOneD

spectrum_id:2582

45:

type:Specdb::NmrOneD

spectrum_id:3276

46:

type:Specdb::NmrOneD

spectrum_id:4910

47:

type:Specdb::NmrOneD

spectrum_id:4911

48:

type:Specdb::NmrOneD

spectrum_id:5892

49:

type:Specdb::NmrOneD

spectrum_id:5893

50:

type:Specdb::NmrOneD

spectrum_id:5894

51:

type:Specdb::NmrOneD

spectrum_id:5895

52:

type:Specdb::NmrOneD

spectrum_id:5896

53:

type:Specdb::NmrOneD

spectrum_id:5897

54:

type:Specdb::NmrOneD

spectrum_id:5898

55:

type:Specdb::NmrOneD

spectrum_id:5899

56:

type:Specdb::NmrOneD

spectrum_id:5900

57:

type:Specdb::NmrOneD

spectrum_id:5901

58:

type:Specdb::NmrOneD

spectrum_id:5902

59:

type:Specdb::NmrOneD

spectrum_id:5903

60:

type:Specdb::NmrOneD

spectrum_id:5904

61:

type:Specdb::NmrOneD

spectrum_id:5905

62:

type:Specdb::NmrOneD

spectrum_id:5906

63:

type:Specdb::NmrOneD

spectrum_id:5907

64:

type:Specdb::NmrOneD

spectrum_id:5908

65:

type:Specdb::NmrOneD

spectrum_id:5909

66:

type:Specdb::NmrOneD

spectrum_id:5910

67:

type:Specdb::NmrOneD

spectrum_id:5911

光谱
生物学性质
1:

cellular:(1):Cytoplasm

cellular:(2):Extracellular

cellular:(3):Lysosome

cellular:(4):Peroxisome

2:

biospecimen:(1):Amniotic Fluid

biospecimen:(2):Blood

biospecimen:(3):Breast Milk

biospecimen:(4):Cellular Cytoplasm

biospecimen:(5):Cerebrospinal Fluid (CSF)

biospecimen:(6):Feces

biospecimen:(7):Saliva

biospecimen:(8):Urine

3:

tissue:(1):Adipose Tissue

tissue:(2):Epidermis

tissue:(3):Erythrocyte

tissue:(4):Fibroblasts

tissue:(5):Intestine

tissue:(6):Kidney

tissue:(7):Liver

tissue:(8):Placenta

tissue:(9):Platelet

tissue:(10):Prostate

tissue:(11):Skeletal Muscle

tissue:(12):Spleen

tissue:(13):Testis

4:

[1]:

name:Adenine phosphoribosyltransferase deficiency (APRT)

smpdb_id:SMP00535

kegg_map_id:

[2]:

name:Adenosine Deaminase Deficiency

smpdb_id:SMP00144

kegg_map_id:

[3]:

name:Adenylosuccinate Lyase Deficiency

smpdb_id:SMP00167

kegg_map_id:

[4]:

name:AICA-Ribosiduria

smpdb_id:SMP00168

kegg_map_id:

[5]:

name:Azathioprine Action Pathway

smpdb_id:SMP00427

kegg_map_id:

[6]:

name:Gout or Kelley-Seegmiller Syndrome

smpdb_id:SMP00365

kegg_map_id:

[7]:

name:Lesch-Nyhan Syndrome (LNS)

smpdb_id:SMP00364

kegg_map_id:

[8]:

name:Mercaptopurine Action Pathway

smpdb_id:SMP00428

kegg_map_id:

[9]:

name:Mitochondrial DNA depletion syndrome

smpdb_id:SMP00536

kegg_map_id:

[10]:

name:Molybdenum Cofactor Deficiency

smpdb_id:SMP00203

kegg_map_id:

[11]:

name:Myoadenylate deaminase deficiency

smpdb_id:SMP00537

kegg_map_id:

[12]:

name:Purine metabolism

smpdb_id:

kegg_map_id:map00230

[13]:

name:Purine Nucleoside Phosphorylase Deficiency

smpdb_id:SMP00210

kegg_map_id:

[14]:

name:Thioguanine Action Pathway

smpdb_id:SMP00430

kegg_map_id:

[15]:

name:Xanthine Dehydrogenase Deficiency (Xanthinuria)

smpdb_id:SMP00220

kegg_map_id:

[16]:

name:Xanthinuria type I

smpdb_id:SMP00512

kegg_map_id:

[17]:

name:Xanthinuria type II

smpdb_id:SMP00513

kegg_map_id:

正常浓度
1:

biospecimen:Amniotic Fluid

concentration_value:0.086 +/- 0.044

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

2:

biospecimen:Blood

concentration_value:2.300 +/- 1.100

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

3:

biospecimen:Blood

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

4:

biospecimen:Blood

concentration_value:11.02 +/- 3.67

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

5:

biospecimen:Blood

concentration_value:1.7 +/- 0.4

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:normal

6:

biospecimen:Blood

concentration_value:2.2 +/- 1.1

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

7:

biospecimen:Blood

concentration_value:11.0294 +/- 3.676

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

8:

biospecimen:Blood

concentration_value:5.6 (3.1-7.1)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

9:

biospecimen:Blood

concentration_value:1.0 +/-0.9

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

10:

biospecimen:Blood

concentration_value:4.87 +/- 0.36

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

11:

biospecimen:Blood

concentration_value:1.0 +/- 0.9

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

12:

biospecimen:Blood

concentration_value:5.6 (3.1-7.1)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

13:

biospecimen:Blood

concentration_value:0.38 +/- 0.18

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

14:

biospecimen:Blood

concentration_value:34.2 +/- 10.3

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

15:

biospecimen:Breast Milk

concentration_value:2.3 +/- 1.5

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

16:

biospecimen:Cellular Cytoplasm

concentration_value:2

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

17:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:5.94 (5.20-6.68)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

18:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:2.6+/-0.6

concentration_units:uM

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

19:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:3.6 (1.8-5.5)

concentration_units:uM

subject_age:Newborn (0-30 days old)

subject_sex:Both

subject_condition:Normal

20:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:2.4 (0.6-4.1)

concentration_units:uM

subject_age:Children (1-13 years old)

subject_sex:Both

subject_condition:Normal

21:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:1.8 (0.6-5.1)

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

22:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

23:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Not Specified

subject_sex:Both

subject_condition:Normal

24:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Children (6 - 18 years old)

subject_sex:Not Specified

subject_condition:Normal

25:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

26:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

27:

biospecimen:Feces

concentration_value:1242

concentration_units:nmol/g wet feces

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

28:

biospecimen:Feces

concentration_value:1540

concentration_units:nmol/g wet feces

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

29:

biospecimen:Feces

concentration_value:1363

concentration_units:nmol/g wet feces

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

30:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

31:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

32:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

33:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

34:

biospecimen:Feces

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

35:

biospecimen:Saliva

concentration_value:3.72 +/- 2.50

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

36:

biospecimen:Saliva

concentration_value:5.83 +/- 5.65

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

37:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

38:

biospecimen:Saliva

concentration_value:1.55 +/- 0.973

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Female

subject_condition:Normal

39:

biospecimen:Saliva

concentration_value:1.57 +/- 1.14

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

40:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

41:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

42:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

43:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

44:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

45:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

46:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

47:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

48:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

49:

biospecimen:Saliva

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

50:

biospecimen:Saliva

concentration_value:2.12 +/- 1.17

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

51:

biospecimen:Saliva

concentration_value:1.91 +/- 0.37

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

52:

biospecimen:Saliva

concentration_value:2.15 +/- 0.34

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

53:

biospecimen:Saliva

concentration_value:1.11 +/- 0.20

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

54:

biospecimen:Saliva

concentration_value:28.15 +/- 11.95

concentration_units:uM

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

55:

biospecimen:Urine

concentration_value:6.63 +/- 6.938

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 13 years old)

subject_sex:Not Specified

subject_condition:Normal

56:

biospecimen:Urine

concentration_value:3.957 +/- 1.470

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Not Specified

subject_condition:Normal

57:

biospecimen:Urine

concentration_value:4.67 (2.8-6.38)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

58:

biospecimen:Urine

concentration_value:4-60

concentration_units:umol/mmol creatinine

subject_age:Children (1 - 18 years old)

subject_sex:Both

subject_condition:Normal

59:

biospecimen:Urine

concentration_value:7.2 (1.8-24.1)

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

60:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

61:

biospecimen:Urine

concentration_value:0-25

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

62:

biospecimen:Urine

concentration_value:17.1 +/- 1.0

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Both

subject_condition:Normal

63:

biospecimen:Urine

concentration_value:5.314 +/- 1.583

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

64:

biospecimen:Urine

concentration_value:7.2 +/- 3.1

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

65:

biospecimen:Urine

concentration_value:5.78 +/- 3.99

concentration_units:umol/mmol creatinine

subject_age:Children (1-13 years old)

subject_sex:Both

subject_condition:Normal

66:

biospecimen:Urine

concentration_value:4.82 +/- 2.20

concentration_units:umol/mmol creatinine

subject_age:Adolescent (13-18 years old)

subject_sex:Both

subject_condition:Normal

67:

biospecimen:Urine

concentration_value:2.30 +/- 2.48

concentration_units:umol/mmol creatinine

subject_age:Adult (>18 years old)

subject_sex:Both

subject_condition:Normal

68:

biospecimen:Urine

concentration_value:<5.2

concentration_units:umol/mmol creatinine

subject_age:Infant (0-1 year old)

subject_sex:Both

subject_condition:Normal

69:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

70:

biospecimen:Urine

concentration_value:

concentration_units:

subject_age:Adult (>18 years old)

subject_sex:Male

subject_condition:Normal

异常浓度
1:

biospecimen:Blood

concentration_value:5.7 +/- 0.4

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Lesch-Nyhan syndrome

2:

biospecimen:Blood

concentration_value:3.1

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Phosphoribosylpyrophosphate Synthetase Superactivity

3:

biospecimen:Blood

concentration_value:52.3

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Heart Transplant

4:

biospecimen:Blood

concentration_value:18.88 +/- 8.30

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:uremia

5:

biospecimen:Blood

concentration_value:5.56 +/- 1.74

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Canavan disease

6:

biospecimen:Blood

concentration_value:1.6

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Male

patient_information:Xanthinuria type 1

7:

biospecimen:Blood

concentration_value:3.6

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Xanthinuria type 1

8:

biospecimen:Blood

concentration_value:0-31

concentration_units:uM

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Xanthinuria type 1

9:

biospecimen:Blood

concentration_value:7.0 +/- 3.2

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Lesch-Nyhan syndrome

10:

biospecimen:Blood

concentration_value:14.706 +/- 11.765

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Uremia

11:

biospecimen:Blood

concentration_value:4.8 +/- 1.0

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Solid tumors

12:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:5.71 (3.99-7.43)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Hydrocephalus

13:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:9.91 (8.01-11.8)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Hydrocephalus

14:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:5.2

concentration_units:uM

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Isolated 3-Methylcrotonyl-CoA Carboxylase Deficiency

15:

biospecimen:Cerebrospinal Fluid (CSF)

concentration_value:2.50 (2.00-3.00)

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Degenerative disc disease

16:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal Cancer

17:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:ankylosing spondylitis

18:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:rheumatoid arthritis

19:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Crohns disease

20:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Ulcerative colitis

21:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Children (6 - 18 years old)

patient_sex:Not Specified

patient_information:Unclassified IBD

22:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

23:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Irritable bowel syndrome

24:

biospecimen:Feces

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Colorectal cancer

25:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Attachment loss 

26:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Periodontal Probing Depth

27:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Oral cancer

28:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Breast cancer

29:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Not Specified

patient_information:Pancreatic cancer

30:

biospecimen:Saliva

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Not Specified

patient_information:Periodontal diseases

31:

biospecimen:Saliva

concentration_value:2.60 +/- 1.07

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Alzheimer's disease

32:

biospecimen:Saliva

concentration_value:2.99 +/- 1.49

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Frontotemporal lobe dementia

33:

biospecimen:Saliva

concentration_value:3.53 +/- 3.84

concentration_units:uM

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Lewy body disease

34:

biospecimen:Urine

concentration_value:9.434 +/- 6.582

concentration_units:umol/mmol creatinine

patient_age:Children (1 - 13 years old)

patient_sex:Not Specified

patient_information:Eosinophilic esophagitis

35:

biospecimen:Urine

concentration_value:16.846

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Female

patient_information:Phosphoribosylpyrophosphate Synthetase Superactivity

36:

biospecimen:Urine

concentration_value:6.8 +/- 4.8

concentration_units:umol/mmol creatinine

patient_age:Not Specified

patient_sex:Both

patient_information:Lung cancer

37:

biospecimen:Urine

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Bladder cancer

38:

biospecimen:Urine

concentration_value:46

concentration_units:umol/mmol creatinine

patient_age:Children (1-13 years old)

patient_sex:Not Specified

patient_information:Molybdenum cofactor deficiency

39:

biospecimen:Urine

concentration_value:65

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Xanthinuria type 1

40:

biospecimen:Urine

concentration_value:74.846

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Lesch-Nyhan syndrome

41:

biospecimen:Urine

concentration_value:88

concentration_units:umol/mmol creatinine

patient_age:Newborn (0-30 days old)

patient_sex:Not Specified

patient_information:Molybdenum cofactor deficiency

42:

biospecimen:Urine

concentration_value:4.3-53.0

concentration_units:umol/mmol creatinine

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Sulfite oxidase deficiency

43:

biospecimen:Urine

concentration_value:61.8-138.0

concentration_units:umol/mmol creatinine

patient_age:Children (1-13 years old)

patient_sex:Both

patient_information:Xanthinuria type 1

44:

biospecimen:Urine

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Autosomal dominant polycystic kidney disease (ADPKD)

45:

biospecimen:Urine

concentration_value:15.12 +/- 17.44

concentration_units:umol/mmol creatinine

patient_age:Adult (>18 years old)

patient_sex:Both

patient_information:Canavan disease

46:

biospecimen:Urine

concentration_value:

concentration_units:

patient_age:Adult (>18 years old)

patient_sex:Male

patient_information:Hepatocellular carcinoma

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reference_text:Zaki MS, Selim L, El-Bassyouni HT, Issa MY, Mahmoud I, Ismail S, Girgis M, Sadek AA, Gleeson JG, Abdel Hamid MS: Molybdenum cofactor and isolated sulphite oxidase deficiencies: Clinical and molecular spectrum among Egyptian patients. Eur J Paediatr Neurol. 2016 Sep;20(5):714-22. doi: 10.1016/j.ejpn.2016.05.011. Epub 2016 May 30.

pubmed_id:27289259

[3]:

reference_text:Rocha S, Ferreira AC, Dias AI, Vieira JP, Sequeira S: Sulfite oxidase deficiency--an unusual late and mild presentation. Brain Dev. 2014 Feb;36(2):176-9. doi: 10.1016/j.braindev.2013.01.013. Epub 2013 Feb 27.

pubmed_id:23452914

[4]:

reference_text:Rashed MS, Saadallah AA, Rahbeeni Z, Eyaid W, Seidahmed MZ, Al-Shahwan S, Salih MA, Osman ME, Al-Amoudi M, Al-Ahaidib L, Jacob M: Determination of urinary S-sulphocysteine, xanthine and hypoxanthine by liquid chromatography-electrospray tandem mass spectrometry. Biomed Chromatogr. 2005 Apr;19(3):223-30.

pubmed_id:15558695

[5]:

reference_text:Clinical and Laboratory Barriers to the Timely Diagnosis of Sulphite Oxidase Deficiency. Proceedings of Singapore Healthcare, 19(2), 94-100.

pubmed_id:

28:

name:Phosphoribosylpyrophosphate Synthetase Superactivity

omim_id:300661

[1]:

reference_text:Sperling O, Eilam G, Sara-Persky-Brosh, De Vries A: Accelerated erythrocyte 5-phosphoribosyl-1-pyrophosphate synthesis. A familial abnormality associated with excessive uric acid production and gout. Biochem Med. 1972 Aug;6(4):310-6.

pubmed_id:4340256

[2]:

reference_text:Garcia-Pavia P, Torres RJ, Rivero M, Ahmed M, Garcia-Puig J, Becker MA: Phosphoribosylpyrophosphate synthetase overactivity as a cause of uric acid overproduction in a young woman. Arthritis Rheum. 2003 Jul;48(7):2036-41. doi: 10.1002/art.11058.

pubmed_id:12847698

KEGG数据库编号
C00262
DrugBank数据库编号
DB04076
foodb数据库编号
FDB003949
ChemSpider数据库编号
768
公共化学化合物编号
790
PDB数据库编号
生物利益的化学实体数据库编号
17368
knapsack数据库编号
C00001502
维基百科编号
Hypoxanthine
代谢途径的数据库编号
HYPOXANTHINE
苯酚资源管理器化合物数据库编号
比格数据库编号
34434
梅林编号
83
虚拟机身份证编号
HXAN
fbonto数据库编号
综合参考
Shaw, Elliott.New synthesis of the purines adenine, hypoxanthine, xanthine, and isoguanine. Journal of Biological Chemistry (1950), 185 439-47.
一般参考
1:

protein_accession:HMDBP00181

name:Xanthine dehydrogenase/oxidase

uniprot_id:P47989

gene_name:XDH

protein_type:Unknown

2:

protein_accession:HMDBP00475

name:Hypoxanthine-guanine phosphoribosyltransferase

uniprot_id:P00492

gene_name:HPRT1

protein_type:Unknown

3:

protein_accession:HMDBP03195

name:Equilibrative nucleoside transporter 2

uniprot_id:Q14542

gene_name:SLC29A2

protein_type:Enzyme

4:

protein_accession:HMDBP03752

name:Purine nucleoside phosphorylase

uniprot_id:P00491

gene_name:PNP

protein_type:Enzyme

蛋白质结合
1:

reference_text:Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762.

pubmed_id:19212411

2:

reference_text:Eells JT, Spector R: Purine and pyrimidine base and nucleoside concentrations in human cerebrospinal fluid and plasma. Neurochem Res. 1983 Nov;8(11):1451-7.

pubmed_id:6656991

3:

reference_text:Ohdoi C, Nyhan WL, Kuhara T: Chemical diagnosis of Lesch-Nyhan syndrome using gas chromatography-mass spectrometry detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jul 15;792(1):123-30.

pubmed_id:12829005

4:

reference_text:Nakayama Y, Kinoshita A, Tomita M: Dynamic simulation of red blood cell metabolism and its application to the analysis of a pathological condition. Theor Biol Med Model. 2005 May 9;2:18.

pubmed_id:15882454

5:

reference_text:Bullo B, Marlewski M, Smolenski RT, Rutkowski B, Swierczynski J, Manitius J: Erythrocyte nucleotides and blood hypoxanthine in patients with uremia evaluated immediately and 24 hours after hemodialysis. Ren Fail. 1996 Mar;18(2):247-52.

pubmed_id:8723362

6:

reference_text:Ihara H, Shino Y, Morita Y, Kawaguchi E, Hashizume N, Yoshida M: Is skeletal muscle damaged by the oxidative stress following anaerobic exercise? J Clin Lab Anal. 2001;15(5):239-43.

pubmed_id:11574951

7:

reference_text:Inokuchi T, Moriwaki Y, Takahashi S, Tsutsumi Z, Ka T, Yamamoto A, Cheng J, Hashimoto-Tamaoki T, Hada T, Yamamoto T: Identification of a new point mutation in hypoxanthine phosphoribosyl transferase responsible for hyperuricemia in a female patient. Metabolism. 2004 Nov;53(11):1500-2.

pubmed_id:15536609

8:

reference_text:Niklasson F: Simultaneous liquid-chromatographic determination of hypoxanthine, xanthine, urate, and creatinine in cerebrospinal fluid, with direct injection. Clin Chem. 1983 Aug;29(8):1543-6.

pubmed_id:6872216

9:

reference_text:Pietz J, Guttenberg N, Gluck L: Hypoxanthine: a marker for asphyxia. Obstet Gynecol. 1988 Nov;72(5):762-6.

pubmed_id:3140152

10:

reference_text:Saari H: Oxygen derived free radicals and synovial fluid hyaluronate. Ann Rheum Dis. 1991 Jun;50(6):389-92.

pubmed_id:1711835

11:

reference_text:Castro-Gago M, Rodriguez IN, Rodriguez-Nunez A, Guitian JP, Rocamonde SL, Rodriguez-Segade S: Therapeutic criteria in hydrocephalic children. Childs Nerv Syst. 1989 Dec;5(6):361-3.

pubmed_id:2611770

12:

reference_text:Storm H, Rognum TO, Saugstad OD, Skullerud K, Reichelt KL: Beta-endorphin immunoreactivity in spinal fluid and hypoxanthine in vitreous humour related to brain stem gliosis in sudden infant death victims. Eur J Pediatr. 1994 Sep;153(9):675-81.

pubmed_id:7957429

13:

reference_text:Koellner G, Luic M, Shugar D, Saenger W, Bzowska A: Crystal structure of calf spleen purine nucleoside phosphorylase in a complex with hypoxanthine at 2.15 A resolution. J Mol Biol. 1997 Jan 17;265(2):202-16.

pubmed_id:9020983

14:

reference_text:Kaya M, Moriwaki Y, Ka T, Inokuchi T, Yamamoto A, Takahashi S, Tsutsumi Z, Tsuzita J, Oku Y, Yamamoto T: Plasma concentrations and urinary excretion of purine bases (uric acid, hypoxanthine, and xanthine) and oxypurinol after rigorous exercise. Metabolism. 2006 Jan;55(1):103-7.

pubmed_id:16324927

15:

reference_text:Smolenska Z, Kaznowska Z, Zarowny D, Simmonds HA, Smolenski RT: Effect of methotrexate on blood purine and pyrimidine levels in patients with rheumatoid arthritis. Rheumatology (Oxford). 1999 Oct;38(10):997-1002.

pubmed_id:10534552

16:

reference_text:Saiki S, Sato T, Kohzuki M, Kamimoto M, Yosida T: Changes in serum hypoxanthine levels by exercise in obese subjects. Metabolism. 2001 Jun;50(6):627-30.

pubmed_id:11398135

17:

reference_text:Gudbjornsson B, Zak A, Niklasson F, Hallgren R: Hypoxanthine, xanthine, and urate in synovial fluid from patients with inflammatory arthritides. Ann Rheum Dis. 1991 Oct;50(10):669-72.

pubmed_id:1958086

18:

reference_text:Saiki S, Sato T, Hiwatari M, Harada T, Oouchi M, Kamimoto M: Relation between changes in serum hypoxanthine levels by exercise and daily physical activity in the elderly. Tohoku J Exp Med. 1999 May;188(1):71-4.

pubmed_id:10494902

19:

reference_text:Duranton F, Cohen G, De Smet R, Rodriguez M, Jankowski J, Vanholder R, Argiles A: Normal and pathologic concentrations of uremic toxins. J Am Soc Nephrol. 2012 Jul;23(7):1258-70. doi: 10.1681/ASN.2011121175. Epub 2012 May 24.

pubmed_id:22626821

20:

reference_text:Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043.

pubmed_id:32033212

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