甲氨蝶呤,临床注释,变异和临床注释数据

甲氨蝶呤

临床注释ID

1451553580

药物名称(英)

methotrexate

变异单倍型

rs1045642

基因

ABCB1

证据级别

水平覆盖

水平修饰符

Tier 1 VIP

表现型类别(英)

Metabolism/PK

表现型类别

代谢/PK

分数

0.0

PMID计数

计数的证据

表现型

Burkitt 淋巴瘤；淋巴瘤，T 细胞；前体细胞淋巴细胞白血病-淋巴瘤

表现型(英)

Burkitt Lymphoma;Lymphoma, T-Cell;Precursor Cell Lymphoblastic Leukemia-Lymphoma

最新日期

2021-12-13

URL

https://www.pharmgkb.org/clinicalAnnotation/1451553580

专业人口(英)

Pediatric

专业人口

儿科

临床等位基因

id	等位基因	注释文本
425	GG	Patients with the rs1045642 GG genotype may have decreased concentrations of methotrexate as compared to patients with the AA or AG genotypes. However, conflicting evidence has been reported. This annotation only covers the pharmacokinetic relationship between rs1045642 and methotrexate and does not include evidence about clinical outcomes. Other genetic and clinical factors may also influence methotrexate concentrations.
424	AG	Patients with the rs1045642 AG genotype may have increased concentrations of methotrexate as compared to patients with the GG genotype. However, conflicting evidence has been reported. This annotation only covers the pharmacokinetic relationship between rs1045642 and methotrexate and does not include evidence about clinical outcomes. Other genetic and clinical factors may also influence methotrexate concentrations.
423	AA	Patients with the rs1045642 AA genotype may have increased concentrations of methotrexate as compared to patients with the GG genotype. However, conflicting evidence has been reported. This annotation only covers the pharmacokinetic relationship between rs1045642 and methotrexate and does not include evidence about clinical outcomes. Other genetic and clinical factors may also influence methotrexate concentrations.

临床证据

id	证据的ID	总结
14602	1451614946	Allele G is not associated with exposure to methotrexate in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to allele A.
14601	1451553370	Genotype AG is associated with increased concentrations of methotrexate in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to genotype GG.
14600	1451465061	Genotype AA is not associated with concentrations of methotrexate in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to genotypes AG + GG.
14599	1449003393	Genotypes AA + AG are not associated with concentrations of methotrexate in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to genotype GG.
34	1296598882	Genotype AA is associated with increased concentrations of methotrexate in people with Burkitt Lymphoma, Lymphoma, T-Cell and Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to genotype GG.

临床病史

id	类型	评论
58	Update	Added PMID 33501733 to evidence
57	Create	Created

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