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当前位置:药药网 / 数据中心 / 临床注释,变异和临床注释数据
甲氨蝶呤
临床注释ID
1451553595
药物名称(英)
methotrexate
变异单倍型
rs1045642
基因
ABCB1
证据级别
4
水平覆盖
水平修饰符
Tier 1 VIP
表现型类别(英)
Efficacy
表现型类别
功效
分数
-1.25
PMID计数
2
计数的证据
3
表现型
前体细胞淋巴细胞白血病-淋巴瘤
表现型(英)
Precursor Cell Lymphoblastic Leukemia-Lymphoma
最新日期
2021-10-21
URL
https://www.pharmgkb.org/clinicalAnnotation/1451553595
专业人口(英)
Pediatric
专业人口
儿科
临床等位基因
id
等位基因
注释文本
422
GG
The current evidence base suggests that there is no significant association between the rs1045642 GG genotype and response to methotrexate in patients with acute lymphoblastic leukemia (ALL). However, conflicting evidence has been reported. Other genetic and clinical factors may also influence response to methotrexate.
421
AG
The current evidence base suggests that there is no significant association between the rs1045642 AG genotype and response to methotrexate in patients with acute lymphoblastic leukemia (ALL). However, conflicting evidence has been reported. Other genetic and clinical factors may also influence response to methotrexate.
420
AA
The current evidence base suggests that there is no significant association between the rs1045642 AA genotype and response to methotrexate in patients with acute lymphoblastic leukemia (ALL). However, conflicting evidence has been reported. Other genetic and clinical factors may also influence response to methotrexate.
临床证据
id
证据的ID
总结
33
1451553540
Genotypes AA + AG are associated with decreased response to methotrexate in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to genotype GG.
32
1451553526
Allele G is not associated with risk of Drug Toxicity due to methotrexate in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to allele A.
31
1449003004
Allele A is not associated with response to methotrexate in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to allele G.
临床病史
id
类型
评论
56
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