甲氨蝶呤,临床注释,变异和临床注释数据

甲氨蝶呤

临床注释ID

1451551846

药物名称(英)

methotrexate

变异单倍型

rs11545077

基因

GGH

证据级别

水平覆盖

水平修饰符

表现型类别(英)

Efficacy

表现型类别

功效

分数

2.5

PMID计数

计数的证据

表现型

前体细胞淋巴细胞白血病-淋巴瘤

表现型(英)

Precursor Cell Lymphoblastic Leukemia-Lymphoma

最新日期

2021-10-20

URL

https://www.pharmgkb.org/clinicalAnnotation/1451551846

专业人口(英)

Pediatric

专业人口

儿科

临床等位基因

id	等位基因	注释文本
407	TT	Patients with acute lymphoblastic leukemia (ALL) and the rs11545077 TT genotype may have a decreased response to methotrexate as compared to patients with the CC or CT genotypes. Other genetic and clinical factors may also influence response to methotrexate.
406	CT	Patients with acute lymphoblastic leukemia (ALL) and the rs11545077 CT genotype may have an increased response to methotrexate as compared to patients with the TT genotype. Other genetic and clinical factors may also influence response to methotrexate.
405	CC	Patients with acute lymphoblastic leukemia (ALL) and the rs11545077 CC genotype may have an increased response to methotrexate as compared to patients with the TT genotype. Other genetic and clinical factors may also influence response to methotrexate.

临床证据

id	证据的ID	总结
14715	1451551766	Genotypes CC + CT are associated with increased response to methotrexate in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to genotype TT.

临床病史

id	类型	评论
51	Create	Created

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