顺铂,临床注释,变异和临床注释数据

顺铂

临床注释ID

1451551528

药物名称(英)

cisplatin

变异单倍型

rs2336219

基因

ERCC1

证据级别

3

水平覆盖

水平修饰符

表现型类别(英)

Efficacy

表现型类别

功效

分数

0.0

PMID计数

1

计数的证据

1

表现型

卵巢肿瘤

表现型(英)

Ovarian Neoplasms

最新日期

2021-10-20

URL

https://www.pharmgkb.org/clinicalAnnotation/1451551528

专业人口(英)

专业人口

临床等位基因

id	等位基因	注释文本
404	GG	Patients with the rs2336219 GG genotype may have an increased response to cisplatin as compared to patients with the AA genotype. Other genetic and clinical factors may also influence response to cisplatin.
403	AG	Patients with the rs2336219 AG genotype may have an increased response to cisplatin as compared to patients with the AA genotype. Other genetic and clinical factors may also influence response to cisplatin.
402	AA	Patients with the rs2336219 AA genotype may have a decreased response to cisplatin as compared to patients with the AG or GG genotypes. Other genetic and clinical factors may also influence response to cisplatin.

临床证据

id	证据的ID	总结
14714	1451551163	Genotypes AG + GG are associated with increased response to cisplatin in women with Ovarian Neoplasms as compared to genotype AA.

临床病史

id	类型	评论
50	Create	Created

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