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当前位置:药药网 / 数据中心 / 临床注释,变异和临床注释数据
依法韦仑
临床注释ID
1451243980
药物名称(英)
efavirenz
变异单倍型
CYP2B6*1, CYP2B6*2, CYP2B6*6, CYP2B6*18, CYP2B6*38
基因
CYP2B6
证据级别
1A
水平覆盖
水平修饰符
Tier 1 VIP
表现型类别(英)
Toxicity
表现型类别
毒性
分数
211.5
PMID计数
12
计数的证据
14
表现型
艾滋病毒感染
表现型(英)
HIV Infections
最新日期
2021-03-24
URL
https://www.pharmgkb.org/clinicalAnnotation/1451243980
专业人口(英)
专业人口
临床等位基因
id
等位基因
注释文本
155
*38
The CYP2B6*38 allele is assigned as a no function allele by CPIC. Patients carrying the CYP2B6*38 allele in combination with a normal, decreased, no, or increased function allele may have increased risk of adverse events (eg. liver toxicity or CNS side effects) when treated with efavirenz as compared to patients with two normal function alleles. Other genetic and clinical factors may also influence toxicity of efavirenz.
154
*18
The CYP2B6*18 allele is assigned as a no function allele by CPIC. Patients carrying the CYP2B6*18 allele in combination with a normal, decreased, no, or increased function allele may have increased risk of adverse events (eg. liver toxicity or CNS side effects) when treated with efavirenz as compared to patients with two normal function alleles. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence toxicity of efavirenz.
153
*6
The CYP2B6*6 allele is assigned as a decreased function allele by CPIC. Patients carrying the CYP2B6*6 allele in combination with a normal, decreased, no, or increased function allele may have increased risk of adverse events (eg. liver toxicity or CNS side effects) when treated with efavirenz as compared to patients with two normal function alleles. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence toxicity of efavirenz.
152
*2
The CYP2B6*2 allele is assigned as a normal function allele by CPIC. Patients carrying CYP2B6*2 allele in combination with another normal function allele may have decreased risk of adverse events (eg. liver toxicity or CNS side effects) when treated with efavirenz as compared to patients with a no or decreased function allele in combination with a normal or increased function allele or with two no or decreased function alleles. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence the toxicity of efavirenz.
151
*1
The CYP2B6*1 allele is assigned as a normal function allele by CPIC. Patients carrying CYP2B6*1 allele in combination with another normal function allele may have decreased risk of adverse events (eg. liver toxicity or CNS side effects) when treated with efavirenz as compared to patients with a no or decreased function allele in combination with a normal or increased function allele or with two no or decreased function alleles. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence the toxicity of efavirenz.
临床证据
id
证据的ID
总结
14703
1449156770
CYP2B6 *6/*6 is associated with increased likelihood of Toxic liver disease when treated with efavirenz in people with HIV as compared to CYP2B6 *1/*1.
14702
1449156721
CYP2B6 *6 + *38 are associated with increased risk of Neurotoxicity Syndromes when treated with efavirenz as compared to CYP2B6 *1/*1.
14701
1448994067
CYP2B6 *2/*2 is associated with increased risk of Central Nervous System Diseases when treated with efavirenz in people with HIV as compared to CYP2B6 *1/*1.
14700
1448993746
CYP2B6 *6/*6 is associated with increased risk of Long QT Syndrome when exposed to efavirenz in healthy individuals as compared to CYP2B6 *1/*1.
14699
1448993721
CYP2B6 *6 is associated with increased risk of Toxic liver disease when treated with efavirenz in people with HIV as compared to CYP2B6 *1/*1.
98
1184168515
CYP2B6 *1 is not associated with Neurotoxicity Syndromes when treated with efavirenz in people with HIV as compared to CYP2B6 *6.
97
827707534
CYP2B6 *6/*6 is associated with increased risk of drug-induced liver injury when treated with efavirenz in people with HIV as compared to CYP2B6 *1/*1.
96
1448993810
Genotypes CC + CT are associated with decreased risk of Central Nervous System Diseases when treated with efavirenz in people with HIV Infections as compared to genotype TT.
95
1448636199
Genotype CC is associated with decreased likelihood of Drug Toxicity when treated with efavirenz in people with HIV Infections as compared to genotype TT.
94
1184473287
Genotype TT is associated with increased risk of Central Nervous System Diseases when treated with efavirenz in people with HIV Infections.
93
1183634232
Genotypes CC + CT are not associated with risk of Neurotoxicity Syndromes when treated with efavirenz in people with HIV Infections as compared to genotype TT.
92
1451289240
Allele C is not associated with increased likelihood of Central Nervous System Diseases when treated with efavirenz in people with HIV Infections as compared to allele T.
91
PA166182846
Annotation of DPWG Guideline for efavirenz and CYP2B6
90
PA166182603
Annotation of CPIC Guideline for efavirenz and CYP2B6
临床病史
id
类型
评论
257
Update
CA score added as part of scoring system release. LOE assigned following curator review.
256
Update
updated text
255
Create
Created
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