奥氮平,临床注释,变异和临床注释数据

id	等位基因	注释文本
130	TT	Patients with two X-chromosomes, the TT genotype and psychiatric disorders who are treated with olanzapine may have a decreased, but not absent, risk of weight gain as compared to patients with the CC genotype. However, some studies find no association with weight gain. Other genetic and clinical factors may also influence a patient's risk for weight gain with antipsychotic treatment. This gene is on the X chromosome therefore some individuals may have only one allele.
129	T	Patients with one X-chromosome, the T genotype and psychiatric disorders who are treated with olanzapine may have a decreased risk of weight gain as compared to patients with the C genotype. This gene is on the X chromosome and males have only one allele. However, some studies find no association with weight gain. Other genetic and clinical factors may also influence a patient's risk for weight gain with antipsychotic treatment.
128	CT	Patients with two X-chromosomes, the CT genotype and psychiatric disorders who are treated with olanzapine may have a decreased, but not absent, risk of weight gain as compared to patients with the CC genotype. However, some studies find no association with weight gain. Other genetic and clinical factors may also influence a patient's risk for weight gain with antipsychotic treatment. This gene is on the X chromosome therefore some individuals may have only one allele.
127	CC	Patients with two X-chromosomes, the CC genotype and psychiatric disorders who are treated with olanzapine may have an increased risk of weight gain as compared to patients with the TT genotype. However, some studies find no association with weight gain. Other genetic and clinical factors may also influence a patient's risk for weight gain with antipsychotic treatment. This gene is on the X chromosome therefore some individuals may have only one allele.
126	C	Patients with one X-chromosome, the C genotype and psychiatric disorders who are treated with olanzapine may have an increased risk of weight gain as compared to patients with the T genotype. However, some studies find no association with weight gain. Other genetic and clinical factors may also influence a patient's risk for weight gain with antipsychotic treatment.

等位基因

注释文本

Patients with two X-chromosomes, the TT genotype and psychiatric disorders who are treated with olanzapine may have a decreased, but not absent, risk of weight gain as compared to patients with the CC genotype. However, some studies find no association with weight gain. Other genetic and clinical factors may also influence a patient's risk for weight gain with antipsychotic treatment. This gene is on the X chromosome therefore some individuals may have only one allele.

129

Patients with one X-chromosome, the T genotype and psychiatric disorders who are treated with olanzapine may have a decreased risk of weight gain as compared to patients with the C genotype. This gene is on the X chromosome and males have only one allele. However, some studies find no association with weight gain. Other genetic and clinical factors may also influence a patient's risk for weight gain with antipsychotic treatment.

128

Patients with two X-chromosomes, the CT genotype and psychiatric disorders who are treated with olanzapine may have a decreased, but not absent, risk of weight gain as compared to patients with the CC genotype. However, some studies find no association with weight gain. Other genetic and clinical factors may also influence a patient's risk for weight gain with antipsychotic treatment. This gene is on the X chromosome therefore some individuals may have only one allele.

127

Patients with two X-chromosomes, the CC genotype and psychiatric disorders who are treated with olanzapine may have an increased risk of weight gain as compared to patients with the TT genotype. However, some studies find no association with weight gain. Other genetic and clinical factors may also influence a patient's risk for weight gain with antipsychotic treatment. This gene is on the X chromosome therefore some individuals may have only one allele.

126

Patients with one X-chromosome, the C genotype and psychiatric disorders who are treated with olanzapine may have an increased risk of weight gain as compared to patients with the T genotype. However, some studies find no association with weight gain. Other genetic and clinical factors may also influence a patient's risk for weight gain with antipsychotic treatment.

id	证据的ID	总结
14693	1448998884	Genotype CC is associated with increased likelihood of Weight gain when treated with amisulpride, clozapine, olanzapine, quetiapine or risperidone in people with schizoaffective disorder and Schizophrenia as compared to genotypes CT + TT.
14692	1448998799	Allele T is associated with decreased likelihood of Obesity when treated with antipsychotics, clozapine, olanzapine or risperidone in people with schizoaffective disorder and Schizophrenia as compared to allele C.
14691	1448998639	Allele T is not associated with increased Weight gain when treated with olanzapine or risperidone in women with Schizophrenia as compared to allele C.
14690	1448997846	Allele C is associated with increased severity of Weight gain when treated with olanzapine in people with schizoaffective disorder and Schizophrenia as compared to allele T.
14689	608431041	Allele T is associated with decreased risk of Weight gain when treated with olanzapine in people with Schizophrenia as compared to allele C.
14688	608431038	Allele T is associated with decreased risk of Weight gain when treated with olanzapine in people with Schizophrenia as compared to allele C.
14687	608431026	Allele T is associated with decreased risk of Weight gain when treated with olanzapine in people with Depressive Disorder or Schizophrenia as compared to allele C.
14686	769261698	Allele C is associated with increased risk of Weight gain when treated with amisulpride, clozapine, haloperidol, iloperidone, olanzapine, quetiapine, risperidone and ziprasidone as compared to allele T.
14685	981478537	Allele C is not associated with Weight gain when treated with olanzapine in people with Mental Disorders as compared to allele T.
14684	981477934	Allele T is not associated with increased likelihood of Weight gain when treated with clozapine, haloperidol, olanzapine or risperidone in people with Schizophrenia as compared to allele C.
14606	1449000436	Allele T is not associated with increased severity of Weight gain when treated with olanzapine in people with Schizophrenia as compared to genotype CC.

证据的ID

总结

14693

1448998884

Genotype CC is associated with increased likelihood of Weight gain when treated with amisulpride, clozapine, olanzapine, quetiapine or risperidone in people with schizoaffective disorder and Schizophrenia as compared to genotypes CT + TT.

14692

1448998799

Allele T is associated with decreased likelihood of Obesity when treated with antipsychotics, clozapine, olanzapine or risperidone in people with schizoaffective disorder and Schizophrenia as compared to allele C.

14691

1448998639

Allele T is not associated with increased Weight gain when treated with olanzapine or risperidone in women with Schizophrenia as compared to allele C.

14690

1448997846

Allele C is associated with increased severity of Weight gain when treated with olanzapine in people with schizoaffective disorder and Schizophrenia as compared to allele T.

14689

608431041

Allele T is associated with decreased risk of Weight gain when treated with olanzapine in people with Schizophrenia as compared to allele C.

14688

608431038

Allele T is associated with decreased risk of Weight gain when treated with olanzapine in people with Schizophrenia as compared to allele C.

14687

608431026

Allele T is associated with decreased risk of Weight gain when treated with olanzapine in people with Depressive Disorder or Schizophrenia as compared to allele C.

14686

769261698

Allele C is associated with increased risk of Weight gain when treated with amisulpride, clozapine, haloperidol, iloperidone, olanzapine, quetiapine, risperidone and ziprasidone as compared to allele T.

14685

981478537

Allele C is not associated with Weight gain when treated with olanzapine in people with Mental Disorders as compared to allele T.

14684

981477934

Allele T is not associated with increased likelihood of Weight gain when treated with clozapine, haloperidol, olanzapine or risperidone in people with Schizophrenia as compared to allele C.

14606

1449000436

Allele T is not associated with increased severity of Weight gain when treated with olanzapine in people with Schizophrenia as compared to genotype CC.

id	类型	评论
233	Update	CA score added as part of scoring system release. LOE may have automatically changed based on new score but may be subject to further changes upon curator review.
232	Update	Altered language for x-linked genes to specify numbers of chromosomes.
231	Create	Created

类型

233

Update

CA score added as part of scoring system release. LOE may have automatically changed based on new score but may be subject to further changes upon curator review.

232

Update

Altered language for x-linked genes to specify numbers of chromosomes.

231

Create

Created