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当前位置:药药网 / 数据中心 / 临床注释,变异和临床注释数据
氯膦酸盐
临床注释ID
1451285000
药物名称(英)
clodronate
变异单倍型
rs1544410
基因
VDR
证据级别
3
水平覆盖
水平修饰符
表现型类别(英)
Efficacy
表现型类别
功效
分数
2.75
PMID计数
1
计数的证据
1
表现型
表现型(英)
最新日期
2021-03-24
URL
https://www.pharmgkb.org/clinicalAnnotation/1451285000
专业人口(英)
专业人口
临床等位基因
id
等位基因
注释文本
125
TT
Patients with the TT genotype may have decreased likelihood of resistance when treated with clodronate in people with Osteitis Deformans as compared to patients with the CC or CT genotype. Other genetic and clinical factors may also influence the response to clodronate.
124
CT
Patients with the CT genotype may have increased likelihood of resistance when treated with clodronate in people with Osteitis Deformans as compared to patients with the TT genotype. Other genetic and clinical factors may also influence the response to clodronate.
123
CC
Patients with the CC genotype may have increased likelihood of resistance when treated with clodronate in people with Osteitis Deformans as compared to patients with the TT genotype. Other genetic and clinical factors may also influence the response to clodronate.
临床证据
id
证据的ID
总结
14683
655386860
Allele C is associated with increased likelihood of resistance when treated with clodronate in people with Osteitis Deformans.
临床病史
id
类型
评论
230
Update
CA score added as part of scoring system release. LOE may have automatically changed based on new score but may be subject to further changes upon curator review.
229
Create
Created
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