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当前位置:药药网 / 数据中心 / 临床注释,变异和临床注释数据
他克莫司
临床注释ID
1183680656
药物名称(英)
tacrolimus
变异单倍型
rs1057868
基因
POR
证据级别
4
水平覆盖
水平修饰符
表现型类别(英)
Toxicity
表现型类别
毒性
分数
-0.5
PMID计数
3
计数的证据
3
表现型
肾移植
表现型(英)
Kidney Transplantation
最新日期
2021-03-24
URL
https://www.pharmgkb.org/clinicalAnnotation/1183680656
专业人口(英)
Pediatric
专业人口
儿科
临床等位基因
id
等位基因
注释文本
72
TT
Patients with the TT (POR *28/*28) genotype and Kidney Transplantation who are treated with tacrolimus may have an increased risk for developing new-onset diabetes after transplantation, however this has been contradicted in some studies. Other genetic and clinical factors may also influence a patient's response to tacrolimus.
71
CT
Patients with the CT (POR *1/*28) genotype and Kidney Transplantation who are treated with tacrolimus may have an increased risk for developing new-onset diabetes after transplantation as compared to patients with the CC (*1/*1) genotype, however this has been contradicted in some studies. Other genetic and clinical factors may also influence a patient's response to tacrolimus.
70
CC
Patients with the CC (POR *1/*1) genotype and Kidney Transplantation who are treated with tacrolimus may have a decreased, but not absent, risk for developing new-onset diabetes after transplantation as compared to patients with the CT and TT (*1/*28 and *28/*28) genotype, however this has been contradicted in some studies. Other genetic and clinical factors may also influence a patient's response to tacrolimus.
临床证据
id
证据的ID
总结
14679
1449183025
Genotypes CC + CT is not associated with risk of Diabetes Mellitus when treated with tacrolimus in children with Kidney Transplantation as compared to genotype TT.
14678
1184483206
Allele T is not associated with new-onset diabetes mellitus when treated with tacrolimus in people with Kidney Transplantation as compared to allele C.
14677
1183680651
Genotypes CT + TT are associated with increased risk of Diabetes Mellitus when treated with tacrolimus in people with Kidney Transplantation as compared to genotype CC.
临床病史
id
类型
评论
224
Update
CA score added as part of scoring system release. LOE may have automatically changed based on new score but may be subject to further changes upon curator review.
223
Update
only ADR evidence
222
Update
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