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当前位置:药药网 / 数据中心 / 临床注释,变异和临床注释数据
甲氨蝶呤
临床注释ID
1451257700
药物名称(英)
methotrexate
变异单倍型
rs1801394
基因
MTRR
证据级别
3
水平覆盖
水平修饰符
表现型类别(英)
Efficacy
表现型类别
功效
分数
4.75
PMID计数
3
计数的证据
3
表现型
关节炎,青少年类风湿;关节炎,类风湿
表现型(英)
Arthritis, Juvenile Rheumatoid;Arthritis, Rheumatoid
最新日期
2021-03-24
URL
https://www.pharmgkb.org/clinicalAnnotation/1451257700
专业人口(英)
Pediatric
专业人口
儿科
临床等位基因
id
等位基因
注释文本
66
GG
Patients with the GG genotype and Rheumatoid Arthritis or Juvenile Rheumatoid Arthritis may have increased response when treated with methotrexate as compared to patients with the AA genotype. Other genetic and clinical factors may also influence methotrexate response.
65
AG
Patients with the AG genotype and Rheumatoid Arthritis or Juvenile Rheumatoid Arthritis may have decreased response when treated with methotrexate as compared to patients with the GG genotype. Other genetic and clinical factors may also influence methotrexate response.
64
AA
Patients with the AA genotype and Rheumatoid Arthritis or Juvenile Rheumatoid Arthritis may have decreased response when treated with methotrexate as compared to patients with the GG genotype. Other genetic and clinical factors may also influence methotrexate response.
临床证据
id
证据的ID
总结
14675
1448266186
Genotypes AA + AG is associated with decreased response to methotrexate in people with Arthritis, Rheumatoid as compared to genotype GG.
14598
1449557869
Allele A is associated with decreased response to methotrexate in people with Arthritis, Rheumatoid as compared to allele G.
14597
1449270277
Genotypes AG + GG is associated with increased response to methotrexate in children with Arthritis, Juvenile Rheumatoid as compared to genotype AA.
临床病史
id
类型
评论
219
Update
CA score added as part of scoring system release. LOE may have automatically changed based on new score but may be subject to further changes upon curator review.
218
Create
Created
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