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当前位置:药药网 / 数据中心 / 临床注释,变异和临床注释数据
替加氟
临床注释ID
1451266065
药物名称(英)
tegafur
变异单倍型
rs3918290
基因
DPYD
证据级别
1A
水平覆盖
水平修饰符
Rare Variant; Tier 1 VIP
表现型类别(英)
Toxicity
表现型类别
毒性
分数
104.0
PMID计数
3
计数的证据
4
表现型
肿瘤
表现型(英)
Neoplasms
最新日期
2021-05-24
URL
https://www.pharmgkb.org/clinicalAnnotation/1451266065
专业人口(英)
专业人口
临床等位基因
id
等位基因
注释文本
60
TT
Patients with the rs3918290 TT genotype and cancer who are treated with tegafur, a fluoropyrimidine, may have an increased risk of drug toxicity as compared to patients with the CC genotype. This drug-variant pair has been assigned a 鈥渘o recommendation鈥?by CPIC, as it was determined to be not clinically actionable. Other genetic and clinical factors may also influence response to fluoropyrimidine-based chemotherapy.
59
CT
Patients with the rs3918290 CT genotype and cancer who are treated with tegafur, a fluoropyrimidine, may have an increased risk of drug toxicity as compared to patients with the CC genotype. This drug-variant pair has been assigned a 鈥渘o recommendation鈥?by CPIC, as it was determined to be not clinically actionable. Other genetic and clinical factors may also influence response to fluoropyrimidine-based chemotherapy.
58
CC
Patients with the rs3918290 CC genotype and cancer who are treated with tegafur, a fluoropyrimidine, may have a decreased, but not absent, risk of drug toxicity as compared to patients with the CT or TT genotype. This drug-variant pair has been assigned a 鈥渘o recommendation鈥?by CPIC, as it was determined to be not clinically actionable. Other genetic and clinical factors may also influence response to fluoropyrimidine-based chemotherapy.
临床证据
id
证据的ID
总结
14672
1450952880
Genotypes CT + TT are associated with increased risk of Drug Toxicity when treated with capecitabine, fluorouracil or tegafur in people with Neoplasms as compared to genotype CC.
14671
1183630475
Allele T is associated with increased risk of Drug Toxicity when treated with capecitabine, fluorouracil or tegafur in people with Neoplasms.
14670
827810951
Genotype CT is associated with risk of Neutropenia when treated with tegafur in people with Rectal Neoplasms.
14669
PA166104944
Annotation of DPWG Guideline for tegafur and DPYD
临床病史
id
类型
评论
115
Update
Added DPWG guideline as evidence
114
Update
CA score added as part of scoring system release. LOE assigned following curator review.
113
Update
Minor edits to phenotype descriptions
112
Create
Created
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