美沙酮,临床注释,变异和临床注释数据

美沙酮

临床注释ID

1451223586

药物名称(英)

methadone

变异单倍型

rs351776

基因

PNOC

证据级别

水平覆盖

水平修饰符

表现型类别(英)

Toxicity

表现型类别

毒性

分数

0.0

PMID计数

计数的证据

表现型

新生儿禁欲综合症

表现型(英)

Neonatal Abstinence Syndrome

最新日期

2021-03-24

URL

https://www.pharmgkb.org/clinicalAnnotation/1451223586

专业人口(英)

Pediatric

专业人口

儿科

临床等位基因

id	等位基因	注释文本
33	CC	Infants who have been exposed to methadone in utero and are born to women with the CC genotype may be less likely to require treatment with at least two medications for neonatal abstinence syndrome as compared to infants born to women with the AA or AC genotypes. Be aware that this annotation is on the mother's genotype, even though the phenotype is observed in the infant and that this was not a statistically significant association. Other genetic and clinical factors may also affect severity of neonatal abstinence syndrome.
32	AC	Infants who have been exposed to methadone in utero and are born to women with the AC genotype may be more likely to require treatment with at least two medications for neonatal abstinence syndrome as compared to infants born to women with the CC genotype. Be aware that this annotation is on the mother's genotype, even though the phenotype is observed in the infant and that this was not a statistically significant association. Other genetic and clinical factors may also affect severity of neonatal abstinence syndrome.
31	AA	Infants who have been exposed to methadone in utero and are born to women with the AA genotype may be more likely to require treatment with at least two medications for neonatal abstinence syndrome as compared to infants born to women with the CC genotype. Be aware that this annotation is on the mother's genotype, even though the phenotype is observed in the infant and that this was not a statistically significant association. Other genetic and clinical factors may also affect severity of neonatal abstinence syndrome.

临床证据

id	证据的ID	总结
14641	1451222211	Allele A is associated with increased severity of Neonatal Abstinence Syndrome due to buprenorphine or methadone in women as compared to allele C.

临床病史

id	类型	评论
266	Update	CA score added as part of scoring system release. LOE may have automatically changed based on new score but may be subject to further changes upon curator review.
265	Create	Created

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