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当前位置:药药网 / 数据中心 / 临床注释,变异和临床注释数据
美沙酮
临床注释ID
1451223540
药物名称(英)
methadone
变异单倍型
rs2279343
基因
CYP2B6
证据级别
3
水平覆盖
水平修饰符
Tier 1 VIP
表现型类别(英)
Toxicity
表现型类别
毒性
分数
1.5
PMID计数
1
计数的证据
1
表现型
新生儿禁欲综合症
表现型(英)
Neonatal Abstinence Syndrome
最新日期
2021-03-24
URL
https://www.pharmgkb.org/clinicalAnnotation/1451223540
专业人口(英)
Pediatric
专业人口
儿科
临床等位基因
id
等位基因
注释文本
27
GG
Infants who have been been exposed to methadone in utero and who have the GG genotype may been less likely to require treatment for neonatal abstinence syndrome as compared to infants with the AA genotype. Other genetic and clinical factors may also affect severity of neonatal abstinence syndrome.
26
AG
Infants who have been been exposed to methadone in utero and who have the AG genotype may been less likely to require treatment for neonatal abstinence syndrome as compared to infants with the AA genotype. Other genetic and clinical factors may also affect severity of neonatal abstinence syndrome.
25
AA
Infants who have been been exposed to methadone in utero and who have the AA genotype may been more likely to require treatment for neonatal abstinence syndrome as compared to infants with the AG or GG genotypes. Other genetic and clinical factors may also affect severity of neonatal abstinence syndrome.
临床证据
id
证据的ID
总结
14536
1451222587
Genotype AA is associated with increased severity of Neonatal Abstinence Syndrome due to methadone in infants as compared to genotype AG.
临床病史
id
类型
评论
262
Update
CA score added as part of scoring system release. LOE may have automatically changed based on new score but may be subject to further changes upon curator review.
261
Create
Created
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