酮洛芬；曲马多,临床注释,变异和临床注释数据

id	等位基因	注释文本
4901	*1	Patients carrying the *1 allele in combination with another normal function or a decreased function allele may have a decreased risk of experiencing sedation when treated with postoperative tramadol and ketoprofen as compared to patients with two decreased function alleles or a no function allele in combination with a decreased function or a normal function allele. Other genetic and clinical factors may also affect a patient's risk of sedation when treated with tramadol and ketoprofen.
2489	*41	Patients carrying the *41 allele in combination with a no function or another decreased function allele may have an increased risk of experiencing sedation when treated with postoperative tramadol and ketoprofen as compared to patients with two normal function alleles or a normal function and a decreased function allele. Other genetic and clinical factors may also affect a patient's risk of sedation when treated with tramadol and ketoprofen.
1001	*17	Patients carrying the *17 allele in combination with a normal function allele may have a decreased risk of experiencing sedation when treated with postoperative tramadol and ketoprofen as compared to patients with two decreased function alleles or a no function allele in combination with a decreased function or a normal function allele. Other genetic and clinical factors may also affect a patient's risk of sedation when treated with tramadol and ketoprofen.
1000	*10	Patients carrying the *10 allele in combination with a no function or another decreased function allele may have an increased risk of experiencing sedation when treated with postoperative tramadol and ketoprofen as compared to patients with two normal function alleles or a normal function and a decreased function allele. Other genetic and clinical factors may also affect a patient's risk of sedation when treated with tramadol and ketoprofen.
999	*9	Patients carrying the *9 allele in combination with a normal function allele may have a decreased risk of experiencing sedation when treated with postoperative tramadol and ketoprofen as compared to patients with two decreased function alleles or a no function allele in combination with a decreased function or a normal function allele. Other genetic and clinical factors may also affect a patient's risk of sedation when treated with tramadol and ketoprofen.
998	*6	Patients carrying the *6 allele in combination with a normal function allele may have an increased risk of experiencing sedation when treated with postoperative tramadol and ketoprofen as compared to patients with two normal function alleles or a normal function and a decreased function allele. Other genetic and clinical factors may also affect a patient's risk of sedation when treated with tramadol and ketoprofen.
997	*5	Patients carrying the *5 allele in combination with a normal function allele may have an increased risk of experiencing sedation when treated with postoperative tramadol and ketoprofen as compared to patients with two normal function alleles or a normal function and a decreased function allele. Other genetic and clinical factors may also affect a patient's risk of sedation when treated with tramadol and ketoprofen.
996	*4	Patients carrying the *4 allele in combination with a normal function or a decreased function allele may have an increased risk of experiencing sedation when treated with postoperative tramadol and ketoprofen as compared to patients with two normal function alleles or a normal function and a decreased function allele. Other genetic and clinical factors may also affect a patient's risk of sedation when treated with tramadol and ketoprofen.
995	*3	Patients carrying the *3 allele in combination with a normal function allele may have an increased risk of experiencing sedation when treated with postoperative tramadol and ketoprofen as compared to patients with two normal function alleles or a normal function and a decreased function allele. Other genetic and clinical factors may also affect a patient's risk of sedation when treated with tramadol and ketoprofen.
994	*2	Patients carrying the *2 allele in combination with another normal function allele may have a decreased risk of experiencing sedation when treated with postoperative tramadol and ketoprofen as compared to patients with two decreased function alleles or a no function allele in combination with a decreased function or a normal function allele. Other genetic and clinical factors may also affect a patient's risk of sedation when treated with tramadol and ketoprofen.

等位基因

注释文本

Patients carrying the *1 allele in combination with another normal function or a decreased function allele may have a decreased risk of experiencing sedation when treated with postoperative tramadol and ketoprofen as compared to patients with two decreased function alleles or a no function allele in combination with a decreased function or a normal function allele. Other genetic and clinical factors may also affect a patient's risk of sedation when treated with tramadol and ketoprofen.

2489

*41

Patients carrying the *41 allele in combination with a no function or another decreased function allele may have an increased risk of experiencing sedation when treated with postoperative tramadol and ketoprofen as compared to patients with two normal function alleles or a normal function and a decreased function allele. Other genetic and clinical factors may also affect a patient's risk of sedation when treated with tramadol and ketoprofen.

1001

*17

Patients carrying the *17 allele in combination with a normal function allele may have a decreased risk of experiencing sedation when treated with postoperative tramadol and ketoprofen as compared to patients with two decreased function alleles or a no function allele in combination with a decreased function or a normal function allele. Other genetic and clinical factors may also affect a patient's risk of sedation when treated with tramadol and ketoprofen.

1000

*10

Patients carrying the *10 allele in combination with a no function or another decreased function allele may have an increased risk of experiencing sedation when treated with postoperative tramadol and ketoprofen as compared to patients with two normal function alleles or a normal function and a decreased function allele. Other genetic and clinical factors may also affect a patient's risk of sedation when treated with tramadol and ketoprofen.

999

Patients carrying the *9 allele in combination with a normal function allele may have a decreased risk of experiencing sedation when treated with postoperative tramadol and ketoprofen as compared to patients with two decreased function alleles or a no function allele in combination with a decreased function or a normal function allele. Other genetic and clinical factors may also affect a patient's risk of sedation when treated with tramadol and ketoprofen.

998

Patients carrying the *6 allele in combination with a normal function allele may have an increased risk of experiencing sedation when treated with postoperative tramadol and ketoprofen as compared to patients with two normal function alleles or a normal function and a decreased function allele. Other genetic and clinical factors may also affect a patient's risk of sedation when treated with tramadol and ketoprofen.

997

Patients carrying the *5 allele in combination with a normal function allele may have an increased risk of experiencing sedation when treated with postoperative tramadol and ketoprofen as compared to patients with two normal function alleles or a normal function and a decreased function allele. Other genetic and clinical factors may also affect a patient's risk of sedation when treated with tramadol and ketoprofen.

996

Patients carrying the *4 allele in combination with a normal function or a decreased function allele may have an increased risk of experiencing sedation when treated with postoperative tramadol and ketoprofen as compared to patients with two normal function alleles or a normal function and a decreased function allele. Other genetic and clinical factors may also affect a patient's risk of sedation when treated with tramadol and ketoprofen.

995

Patients carrying the *3 allele in combination with a normal function allele may have an increased risk of experiencing sedation when treated with postoperative tramadol and ketoprofen as compared to patients with two normal function alleles or a normal function and a decreased function allele. Other genetic and clinical factors may also affect a patient's risk of sedation when treated with tramadol and ketoprofen.

994

Patients carrying the *2 allele in combination with another normal function allele may have a decreased risk of experiencing sedation when treated with postoperative tramadol and ketoprofen as compared to patients with two decreased function alleles or a no function allele in combination with a decreased function or a normal function allele. Other genetic and clinical factors may also affect a patient's risk of sedation when treated with tramadol and ketoprofen.

id	证据的ID	总结
14527	1451208260	CYP2D6 1/3 + 1/4 + 1/5 + 1/6 + 4/41 + 6/10 + 10/10 + 41/41 (assigned as intermediate metabolizer phenotype) are associated with increased risk of sedation when treated with ketoprofen and tramadol in people with Pain, Postoperative as compared to CYP2D6 1/1 + 1/2 + 1/9 + 1/10 + 1/17 + 1/41 + 2/2 (assigned as normal metabolizer phenotype) .

证据的ID

总结

14527

1451208260

CYP2D6 *1/*3 + *1/*4 + *1/*5 + *1/*6 + *4/*41 + *6/*10 + *10/*10 + *41/*41 (assigned as intermediate metabolizer phenotype) are associated with increased risk of sedation when treated with ketoprofen and tramadol in people with Pain, Postoperative as compared to CYP2D6 *1/*1 + *1/*2 + *1/*9 + *1/*10 + *1/*17 + *1/*41 + *2/*2 (assigned as normal metabolizer phenotype) .

id	类型	评论
71	Update	CA score added as part of scoring system release. LOE may have automatically changed based on new score but may be subject to further changes upon curator review.
70	Create	Created

类型

Update

CA score added as part of scoring system release. LOE may have automatically changed based on new score but may be subject to further changes upon curator review.

Create

Created

网站地图 - 网站开发 - 网站简介 - 会员服务 - 法律声明 - 联系我们 - 药品招商频道 - 药品信息排行 - 2018年版国家基本药物目录 - 意见反馈

浙ICP备16010490号-2 增值电信业务经营许可证：浙B2-20220931　互联网药品信息服务资格证书编号：(浙)-经营性2023-0215　

浙公网安备:33068302000535
　医药代理商群１：

医药代理商群２：

医药代理商群３：

最新招商产品更多>>