美沙酮,临床注释,变异和临床注释数据

美沙酮

临床注释ID

1451138860

药物名称(英)

methadone

变异单倍型

rs3802279

基因

OPRK1

证据级别

水平覆盖

水平修饰符

表现型类别(英)

Dosage

表现型类别

剂量

分数

2.5

PMID计数

计数的证据

表现型

海洛因依赖

表现型(英)

Heroin Dependence

最新日期

2021-03-24

URL

https://www.pharmgkb.org/clinicalAnnotation/1451138860

专业人口(英)

专业人口

临床等位基因

id	等位基因	注释文本
302	TT	Patients with heroin dependence and the TT genotype may have increased dose requirements of methadone when receiving methadone maintenance therapy (MMT) as compared to patients with the CC genotype. Other genetic and clinical factors may also affect a patient's dose requirements when receiving MMT.
301	CT	Patients with heroin dependence and the CT genotype may have increased dose requirements of methadone when receiving methadone maintenance therapy (MMT) as compared to patients with the CC genotype. Other genetic and clinical factors may also affect a patient's dose requirements when receiving MMT.
300	CC	Patients with heroin dependence and the CC genotype may have decreased dose requirements of methadone when receiving methadone maintenance therapy (MMT) as compared to patients with the CT or TT genotypes. Other genetic and clinical factors may also affect a patient's dose requirements when receiving MMT.

临床证据

id	证据的ID	总结
14466	1451138607	Genotype CC is associated with decreased dose of methadone in people with Heroin Dependence as compared to genotypes CT + TT.

临床病史

id	类型	评论
129	Update	CA score added as part of scoring system release. LOE may have automatically changed based on new score but may be subject to further changes upon curator review.
128	Create	Created

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