甲硝唑,临床注释,变异和临床注释数据

甲硝唑

临床注释ID

1451163460

药物名称(英)

metronidazole

变异单倍型

CYP2A6*1A, CYP2A6*2, CYP2A6*9, CYP2A6*17

基因

CYP2A6

证据级别

水平覆盖

水平修饰符

Tier 1 VIP

表现型类别(英)

Metabolism/PK

表现型类别

代谢/PK

分数

1.375

PMID计数

计数的证据

表现型

表现型(英)

最新日期

2021-03-24

URL

https://www.pharmgkb.org/clinicalAnnotation/1451163460

专业人口(英)

Pediatric

专业人口

儿科

临床等位基因

id	等位基因	注释文本
4892	*17	Patients with one copy of the 17 allele in combination with one copy of the 1A allele may have decreased metabolism of metronidazole as compared to patients with two copies of the *1A allele. However, one study has failed to find this association. Other genetic and clinical factors may also affect metronidazole metabolism. This annotation only covers the pharmacokinetic relationship between CYP2A6 and metronidazole and does not include evidence on clinical outcomes.
4891	*9	Patients with one copy of the 9 allele in combination with one copy of the 1A allele may have decreased metabolism of metronidazole as compared to patients with two copies of the *1A allele. Other genetic and clinical factors may also affect metronidazole metabolism. This annotation only covers the pharmacokinetic relationship between CYP2A6 and metronidazole and does not include evidence on clinical outcomes.
4890	*2	Patients with one copy of the 2 allele in combination with one copy of the 1A allele may have decreased metabolism of metronidazole as compared to patients with two copies of the *1A allele. Other genetic and clinical factors may also affect metronidazole metabolism. This annotation only covers the pharmacokinetic relationship between CYP2A6 and metronidazole and does not include evidence on clinical outcomes.
4889	*1A	Patients with two copies of the 1A allele may have increased metabolism of metronidazole as compared to patients with one copy of the 1A allele in combination with one copy of the 2, 9 or 17 alleles. However, one study found failed to find this association for the 17 allele. Other genetic and clinical factors may also affect metronidazole metabolism. This annotation only covers the pharmacokinetic relationship between CYP2A6 and metronidazole and does not include evidence on clinical outcomes.

临床证据

id	证据的ID	总结
14521	1451162952	CYP2A6 1A/2 + 1A/9 + 1A/17 (assigned as reduced metabolizers phenotype) are associated with decreased metabolism of metronidazole in healthy individuals as compared to CYP2A6 1A/1A (assigned as normal metabolizers phenotype) .
14520	1449576398	CYP2A6 17 is not associated with clearance of metronidazole in infants as compared to CYP2A6 1A.

临床病史

id	类型	评论
94	Update	CA score added as part of scoring system release. LOE may have automatically changed based on new score but may be subject to further changes upon curator review.
93	Create	Created

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