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当前位置:药药网 / 数据中心 / 临床注释,变异和临床注释数据
氢可酮
临床注释ID
1451152801
药物名称(英)
hydrocodone
变异单倍型
CYP2D6*1, CYP2D6*3, CYP2D6*4
基因
CYP2D6
证据级别
3
水平覆盖
水平修饰符
Tier 1 VIP
表现型类别(英)
Toxicity
表现型类别
毒性
分数
2.5
PMID计数
1
计数的证据
1
表现型
阿片类药物相关疾病
表现型(英)
Opioid-Related Disorders
最新日期
2021-03-24
URL
https://www.pharmgkb.org/clinicalAnnotation/1451152801
专业人口(英)
专业人口
临床等位基因
id
等位基因
注释文本
387
*4
Patients carrying the *4 allele in addition to another no function allele may be at a decreased risk of developing opioid dependence as a result of taking hydrocodone as compared to patients carrying at least one normal function allele. Other genetic and clinical factors may also affect a patient's risk of developing opioid dependence.
386
*3
Patients carrying the *3 allele in addition to another no function allele may be at a decreased risk of developing opioid dependence as a result of taking hydrocodone as compared to patients carrying at least one normal function allele. Other genetic and clinical factors may also affect a patient's risk of developing opioid dependence.
385
*1
Patients carrying the *1 allele in addition to another normal function allele or a no function allele may be at an increased risk of developing opioid dependence as a result of taking hydrocodone as compared to patients carrying at least two no function alleles. Other genetic and clinical factors may also affect a patient's risk of developing opioid dependence.
临床证据
id
证据的ID
总结
14433
1451152760
CYP2D6 *3/*3 + *4/*4 are associated with decreased risk of Opioid-Related Disorders due to codeine, hydrocodone or oxycodone as compared to CYP2D6 *1/*1 + *1/*3 + *1/*4.
临床病史
id
类型
评论
5
Update
CA score added as part of scoring system release. LOE may have automatically changed based on new score but may be subject to further changes upon curator review.
4
Create
Created
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