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当前位置:药药网 / 数据中心 / 临床注释,变异和临床注释数据
华法林
临床注释ID
1451148840
药物名称(英)
warfarin
变异单倍型
rs780801862
基因
CYP2C9
证据级别
3
水平覆盖
水平修饰符
Rare Variant; Tier 1 VIP
表现型类别(英)
Metabolism/PK
表现型类别
代谢/PK
分数
0.0
PMID计数
1
计数的证据
1
表现型
表现型(英)
最新日期
2021-03-24
URL
https://www.pharmgkb.org/clinicalAnnotation/1451148840
专业人口(英)
专业人口
临床等位基因
id
等位基因
注释文本
229
TT
Patients with the TT genotype may have decreased metabolism of warfarin as compared to patients with the AA genotype. Other genetic and clinical factors may also affect warfarin metabolism. This annotation only covers the pharmacokinetic relationship between rs780801862 and warfarin and does not include evidence about clinical outcomes.
228
AT
Patients with the AT genotype may have decreased metabolism of warfarin as compared to patients with the AA genotype. Other genetic and clinical factors may also affect warfarin metabolism. This annotation only covers the pharmacokinetic relationship between rs780801862 and warfarin and does not include evidence about clinical outcomes.
227
AA
Patients with the AA genotype may have increased metabolism of warfarin as compared to patients with the AT or TT genotypes. Other genetic and clinical factors may also affect warfarin metabolism. This annotation only covers the pharmacokinetic relationship between rs780801862 and warfarin and does not include evidence about clinical outcomes.
临床证据
id
证据的ID
总结
14583
1451148752
Allele T is associated with decreased catalytic activity of CYP2C9 when assayed with flurbiprofen, naproxen, phenytoin or warfarin as compared to allele A.
临床病史
id
类型
评论
506
Update
CA score added as part of scoring system release. LOE may have automatically changed based on new score but may be subject to further changes upon curator review.
505
Create
Created
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