伊马替尼,临床注释,变异和临床注释数据

伊马替尼

临床注释ID

1451147700

药物名称(英)

imatinib

变异单倍型

CYP3A4*1, CYP3A4*3, CYP3A4*20, CYP3A4*22

基因

CYP3A4

证据级别

水平覆盖

水平修饰符

Tier 1 VIP

表现型类别(英)

Metabolism/PK

表现型类别

代谢/PK

分数

0.0

PMID计数

计数的证据

表现型

表现型(英)

最新日期

2021-03-24

URL

https://www.pharmgkb.org/clinicalAnnotation/1451147700

专业人口(英)

专业人口

临床等位基因

id	等位基因	注释文本
576	*22	Patients carrying at least one copy of the 22 allele may have increased exposure to imatinib as compared to patients with. the1/*1 genotype. This annotation only covers the pharmacokinetic relationship between CYP3A4 genotypes and imatinib and does not include evidence about clinical outcomes. Other genetic and clinical factors may also affect a patient's exposure to imatinib.
575	*20	Patients carrying at least one copy of the 20 allele may have increased exposure to imatinib as compared to patients with. the1/*1 genotype. This annotation only covers the pharmacokinetic relationship between CYP3A4 genotypes and imatinib and does not include evidence about clinical outcomes. Other genetic and clinical factors may also affect a patient's exposure to imatinib.
574	*3	Patients carrying at least one copy of the 3 allele may have increased exposure to imatinib as compared to patients with. the1/*1 genotype. This annotation only covers the pharmacokinetic relationship between CYP3A4 genotypes and imatinib and does not include evidence about clinical outcomes. Other genetic and clinical factors may also affect a patient's exposure to imatinib.
203	1/1	Patients with the 1/1 genotype may have decreased exposure to imatinib as compared to patients carrying at least one copy of the 3, 20 or *22 alleles. This annotation only covers the pharmacokinetic relationship between CYP3A4 genotypes and imatinib and does not include evidence about clinical outcomes. Other genetic and clinical factors may also affect a patient's exposure to imatinib.

临床证据

id	证据的ID	总结
14486	1451147640	CYP3A4 3 + 20 + 22 are associated with increased exposure to fentanyl, imatinib or quetiapine in healthy individuals as compared to CYP3A4 1.

临床病史

id	类型	评论
308	Update	CA score added as part of scoring system release. LOE may have automatically changed based on new score but may be subject to further changes upon curator review.
307	Create	Created

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