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当前位置:药药网 / 数据中心 / 临床注释,变异和临床注释数据
阿普唑仑
临床注释ID
1451144760
药物名称(英)
alprazolam
变异单倍型
rs35599367
基因
CYP3A;CYP3A4
证据级别
3
水平覆盖
水平修饰符
Tier 1 VIP
表现型类别(英)
Metabolism/PK
表现型类别
代谢/PK
分数
2.0
PMID计数
1
计数的证据
1
表现型
表现型(英)
最新日期
2021-03-24
URL
https://www.pharmgkb.org/clinicalAnnotation/1451144760
专业人口(英)
专业人口
临床等位基因
id
等位基因
注释文本
87
GG
Patients with alcoholism, anxiety and the GG genotype may have decreased concentrations of alprazolam as compared to patients with the AG genotype. This annotation over covers the pharmacokinetic relationship between rs35599367 and alprazolam and does not include evidence about clinical outcomes. Other genetic and clinical factors may also affect concentrations of alprazolam in a patient.
86
AG
Patients with alcoholism, anxiety and the AG genotype may have increased concentrations of alprazolam as compared to patients with the GG genotype. This annotation over covers the pharmacokinetic relationship between rs35599367 and alprazolam and does not include evidence about clinical outcomes. Other genetic and clinical factors may also affect concentrations of alprazolam in a patient.
85
AA
There is currently no available evidence regarding an association between the AA genotype and concentrations of alprazolam. Other genetic and clinical factors may also affect concentrations of alprazolam in a patient.
临床证据
id
证据的ID
总结
14477
1451144700
Genotype AG is associated with increased concentrations of alprazolam in men with Alcoholism and Anxiety Disorders as compared to genotype GG.
临床病史
id
类型
评论
491
Update
CA score added as part of scoring system release. LOE may have automatically changed based on new score but may be subject to further changes upon curator review.
490
Create
Created
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