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当前位置:药药网 / 数据中心 / 临床注释,变异和临床注释数据
依法韦仑
临床注释ID
1451129680
药物名称(英)
efavirenz
变异单倍型
rs3211371
基因
CYP2B6
证据级别
4
水平覆盖
水平修饰符
Tier 1 VIP
表现型类别(英)
Metabolism/PK
表现型类别
代谢/PK
分数
-4.75
PMID计数
6
计数的证据
6
表现型
表现型(英)
最新日期
2021-03-24
URL
https://www.pharmgkb.org/clinicalAnnotation/1451129680
专业人口(英)
专业人口
临床等位基因
id
等位基因
注释文本
481
TT
Patients with the TT genotype may have decreased exposure to efavirenz as compared to patients with the CC genotype. However, the majority of studies have failed to find this association. Other genetic and clinical factors may also affect a patient's exposure to efavirenz.
480
CT
Patients with the CT genotype may have decreased exposure to efavirenz as compared to patients with the CC genotype. However, the majority of studies have failed to find this association. Other genetic and clinical factors may also affect a patient's exposure to efavirenz.
479
CC
Patients with the CC genotype may have increased exposure to efavirenz as compared to patients with the CT or TT genotypes. However, the majority of studies have failed to find this association. Other genetic and clinical factors may also affect a patient's exposure to efavirenz.
临床证据
id
证据的ID
总结
14207
827695614
Genotypes CT + TT are not associated with increased plasma exposure of efavirenz in people with HIV Infections as compared to genotype CC.
1896
1451127150
Genotypes CT + TT are associated with decreased exposure to efavirenz in healthy individuals as compared to genotype CC.
1895
1184512390
Genotype TT is not associated with metabolism of efavirenz in people with HIV Infections as compared to genotype CC.
1894
1184473261
Genotype CC is not associated with metabolism of efavirenz in people with HIV Infections as compared to genotype CT.
1893
1183491471
Genotype CC is not associated with clearance of efavirenz in people with HIV Infections as compared to genotype CT.
1892
827807710
Genotype CC is not associated with plasma concentration of efavirenz or nevirapine in people with HIV Infections as compared to genotype CT.
临床病史
id
类型
评论
327
Create
Created
156
Update
CA score added as part of scoring system release. LOE may have automatically changed based on new score but may be subject to further changes upon curator review.
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