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当前位置:药药网 / 数据中心 / 临床注释,变异和临床注释数据
替莫唑胺
临床注释ID
1451126200
药物名称(英)
temozolomide
变异单倍型
rs2229109
基因
ABCB1
证据级别
3
水平覆盖
水平修饰符
Tier 1 VIP
表现型类别(英)
Efficacy
表现型类别
功效
分数
1.75
PMID计数
1
计数的证据
1
表现型
胶质瘤
表现型(英)
Glioma
最新日期
2021-03-24
URL
https://www.pharmgkb.org/clinicalAnnotation/1451126200
专业人口(英)
专业人口
临床等位基因
id
等位基因
注释文本
460
TT
There is currently no available evidence regarding an association between the TT genotype and response to temozolomide as part of radiochemotherapy.
459
CT
Patients with glioma and the CT genotype may have decreased survival rates when treated with temozolomide as part of radiochemotherapy as compared to patients with the CC genotype. However, this association was not replicated in other cohorts. Other genetic and clinical factors may also affect response to temozolomide.
458
CC
Patients with glioma and the CC genotype may have increased survival rates when treated with temozolomide as part of radiochemotherapy as compared to patients with the CT genotype. However, this association was not replicated in other cohorts. Other genetic and clinical factors may also affect response to temozolomide.
临床证据
id
证据的ID
总结
14391
1451126120
Genotype CT is associated with decreased response to temozolomide in people with Glioma as compared to genotype CC.
临床病史
id
类型
评论
361
Update
CA score added as part of scoring system release. LOE may have automatically changed based on new score but may be subject to further changes upon curator review.
360
Create
Created
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