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当前位置:药药网 / 数据中心 / 临床注释,变异和临床注释数据
阿片类药物
临床注释ID
1451141152
药物名称(英)
opioids
变异单倍型
rs9393888
基因
ZNF165
证据级别
3
水平覆盖
水平修饰符
表现型类别(英)
Toxicity
表现型类别
毒性
分数
0.0
PMID计数
1
计数的证据
1
表现型
恶心,呕吐
表现型(英)
Nausea;Vomiting
最新日期
2021-03-24
URL
https://www.pharmgkb.org/clinicalAnnotation/1451141152
专业人口(英)
专业人口
临床等位基因
id
等位基因
注释文本
320
GG
Patients with the GG genotype may experience an increased severity of nausea and vomiting when treated with opioids as compared to patients with the CC or CG genotypes. Other genetic and clinical factors may also affect severity of opioid-induced nausea and vomiting.
319
CG
Patients with the CG genotype may experience a decreased severity of nausea and vomiting when treated with opioids as compared to patients with the GG genotype. Other genetic and clinical factors may also affect severity of opioid-induced nausea and vomiting.
318
CC
Patients with the CC genotype may experience a decreased severity of nausea and vomiting when treated with opioids as compared to patients with the GG genotype. Other genetic and clinical factors may also affect severity of opioid-induced nausea and vomiting.
临床证据
id
证据的ID
总结
14299
1451139390
Allele C is associated with decreased severity of Nausea and Vomiting due to opioids in people with Neoplasms and Pain as compared to allele G.
临床病史
id
类型
评论
476
Update
CA score added as part of scoring system release. LOE may have automatically changed based on new score but may be subject to further changes upon curator review.
475
Create
Created
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