聚乙二醇干扰素α-2b；利巴韦林,临床注释-2,变异和临床注释数据

聚乙二醇干扰素α-2b；利巴韦林

临床注释ID

1446905703

药物名称(英)

peginterferon alfa-2b;ribavirin

变异单倍型

rs7270101

基因

ITPA

证据级别

水平覆盖

水平修饰符

表现型类别(英)

Toxicity

表现型类别

毒性

分数

PMID计数

计数的证据

表现型

贫血；丙型肝炎，慢性

表现型(英)

Anemia;Hepatitis C, Chronic

最新日期

2021/3/24 0:00:00

URL

https://www.pharmgkb.org/clinicalAnnotation/1446905703

专业人口(英)

专业人口

临床等位基因

id	等位基因	注释文本
1122	CC	Patients with the rs7270101 CC genotype and chronic hepatitis C may have a decreased risk of anemia when treated with peg interferon alfa-2b and ribavirin as compared to patients with the AA genotype. However, conflicting evidence has been reported. Other clinical and genetic factors may influence the risk of anemia.
1121	AC	Patients with the rs7270101 AC genotype and chronic hepatitis C may have a decreased risk of anemia when treated with peg interferon alfa-2b and ribavirin as compared to patients with the AA genotype. However, conflicting evidence has been reported. Other clinical and genetic factors may influence the risk of anemia.
1120	AA	Patients with the rs7270101 AA genotype and chronic hepatitis C may have an increased risk of anemia when treated with peg interferon alfa-2b and ribavirin as compared to patients with the AC and CC genotype. However, conflicting evidence has been reported. Other clinical and genetic factors may influence the risk of anemia.

临床证据

id	证据的ID	总结
214	1448532157	Genotype AA is associated with increased likelihood of Anemia, Hemolytic when treated with ribavirin in people with Hepatitis C as compared to genotypes AC + CC.
213	1448255902	Allele C is associated with decreased severity of Anemia when treated with peginterferon alfa-2b and ribavirin in people with as compared to allele A.
212	1447682522	Allele A is not associated with increased risk of Anemia when treated with boceprevir, peginterferon alfa-2b, ribavirin or telaprevir in people with as compared to allele C.
211	1446905501	Genotype AA is associated with increased risk of Anemia when treated with peginterferon alfa-2a, peginterferon alfa-2b and ribavirin in people with Hepatitis C as compared to genotypes AC + CC.
210	1444707735	Allele C is associated with decreased severity of Anemia when treated with peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to allele A.
209	981481593	Allele C is associated with decreased anemia when treated with peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to allele A.

临床病史

id	类型	评论
1612	Update	CA score added as part of scoring system release. LOE assigned following curator review.
1611	Update	Edited text to conform to template, moved drug in sentence, and simplified final statement.
1610	Update	Edited phenotype descriptions and added phenotype tag.
1609	Update	updated text
1608	Update	Reviewed.
1607	Update	Added PMID 26438033
1606	Update	Added PMID 26670100, 20173735
1605	Update	Fixed a typo in the clinical annotation and updated the text to reflect that supporting studies use the composite genotypes of rs1127354 CC and rs7270101 AA to identify "normal ITPas activity" vs. "deficient". Also updated the annotation to reflect drugs are used in combination.
1604	Create