他克莫司,临床注释-2,变异和临床注释数据

他克莫司

临床注释ID

1451214480

药物名称(英)

tacrolimus

变异单倍型

CYP3A5*1, CYP3A5*3, CYP3A5*6, CYP3A5*7

基因

CYP3A5

证据级别

水平覆盖

水平修饰符

Tier 1 VIP

表现型类别(英)

Metabolism/PK

表现型类别

代谢/PK

分数

421.75

PMID计数

143

计数的证据

166

表现型

心脏移植;造血干细胞移植;肾移植;肺移植

表现型(英)

heart transplantation;hematopoietic stem cell transplantation;Kidney Transplantation;lung transplantation

最新日期

2022/3/11 0:00:00

URL

https://www.pharmgkb.org/clinicalAnnotation/1451214480

专业人口(英)

Pediatric

专业人口

儿科

临床等位基因

id	等位基因	注释文本
1098	*7	The CYP3A57 allele has been assigned as a no function allele by CPIC. Patients who are recipients of a kidney, heart, lung or hematopoietic stem cell transplant or a liver transplant with the same CYP3A5 genotype as the recipient and who carry the 7 allele in combination with another no function allele may have decreased metabolism of tacrolimus as compared to patients carrying two normal function alleles or a normal function allele in combination with a no function allele. This annotation only covers the pharmacokinetic relationship between CYP3A5 and tacrolimus and does not include evidence about clinical outcomes. Other genetic and clinical factors may also affect tacrolimus metabolism.
1097	*6	The CYP3A56 allele has been assigned as a no function allele by CPIC. Patients who are recipients of a kidney, heart, lung or hematopoietic stem cell transplant or a liver transplant with the same CYP3A5 genotype as the recipient and who carry the 6 allele in combination with another no function allele may have decreased metabolism of tacrolimus as compared to patients carrying two normal function alleles or a normal function allele in combination with a no function allele. This annotation only covers the pharmacokinetic relationship between CYP3A5 and tacrolimus and does not include evidence about clinical outcomes. Other genetic and clinical factors may also affect tacrolimus metabolism.
1096	*3	The CYP3A53 allele has been assigned as a no function allele by CPIC. Patients who are recipients of a kidney, heart, lung or hematopoietic stem cell transplant or a liver transplant with the same CYP3A5 genotype as the recipient and who carry the 3 allele in combination with another no function allele may have decreased metabolism of tacrolimus as compared to patients carrying two normal function alleles or a normal function allele in combination with a no function allele. However, conflicting evidence has been reported. This annotation only covers the pharmacokinetic relationship between CYP3A5 and tacrolimus and does not include evidence about clinical outcomes. Other genetic and clinical factors may also affect tacrolimus metabolism.
1095	*1	The CYP3A51 allele has been assigned as a normal function allele by CPIC. Patients who are recipients of a kidney, heart, lung or hematopoietic stem cell transplant or a liver transplant with the same CYP3A5 genotype as the recipient and who carry the 1 allele in combination with a normal or no function allele may have increased metabolism of tacrolimus as compared to patients carrying two no function alleles. However, conflicting evidence has been reported. This annotation only covers the pharmacokinetic relationship between CYP3A5 and tacrolimus and does not include evidence about clinical outcomes. Other genetic and clinical factors may also affect tacrolimus metabolism.

临床证据

id	证据的ID	总结
979	1444694284	Genotype CC is associated with increased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to genotypes CT + TT.
978	1444694255	Genotypes CT + TT is associated with decreased dose-adjusted trough concentrations of tacrolimus in people with hemopoietic stem cell transplant as compared to genotype CC.
977	1444694209	Genotypes CT + TT is associated with increased clearance of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
976	1444694176	Genotypes CT + TT is associated with decreased dose-adjusted trough concentrations of tacrolimus in children with Kidney Transplantation as compared to genotype CC.
975	1444694110	Genotypes CT + TT is not associated with concentrations of tacrolimus in people with heart transplantation as compared to genotype CC.
974	1444694094	Genotypes CT + TT is associated with decreased dose-adjusted trough concentrations of tacrolimus in people with heart transplantation as compared to genotype CC.
973	1444693964	Genotype CC is associated with increased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to genotypes CT + TT.
972	1444666410	Genotype CC is associated with increased concentrations of tacrolimus in people with Kidney Transplantation as compared to genotypes CT + TT.
971	1296599155	Genotypes CT + TT is associated with decreased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
970	1185023332	Genotypes CT + TT is associated with increased metabolism of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
969	1185023279	Genotypes CT + TT is associated with decreased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
968	1184998516	Allele C is associated with decreased metabolism of tacrolimus in people with Kidney Transplantation as compared to allele T.
967	1184998389	Genotypes CT + TT are associated with increased metabolism of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
966	1184998356	Genotypes CT + TT are associated with increased metabolism of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
965	1184998169	Genotypes CT + TT is associated with increased metabolism of tacrolimus in children with Kidney Transplantation as compared to genotype CC.
964	1184515781	Genotype CC is not associated with decreased metabolism of tacrolimus in people with Kidney Transplantation as compared to genotype CT.
963	1184515480	Genotypes CT + TT is associated with increased metabolism of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
962	1184515460	Genotypes CT + TT is associated with increased metabolism of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
961	1184515446	Genotype CC is associated with increased PBMC concentrations of tacrolimus in people with Kidney Transplantation as compared to genotypes CT + TT.
960	1184515373	Genotype CT is associated with increased clearance of tacrolimus in Kidney Transplantation as compared to genotype CC.
959	1184515288	Genotypes CT + TT is associated with increased clearance of tacrolimus in Kidney Transplantation as compared to genotype CC.
958	1184515270	Genotypes CT + TT is associated with increased metabolism of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
957	1184515224	Genotype CT is associated with increased clearance of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
956	1184515181	Genotypes CT + TT is associated with increased clearance of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
955	1184515163	Genotypes CT + TT are associated with increased clearance of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
954	1184515035	Genotype CC is associated with increased trough concentrations of tacrolimus in people with Kidney Transplantation as compared to genotypes CT + TT.
953	1184515029	Genotype CT is associated with increased clearance of tacrolimus in Kidney Transplantation as compared to genotype CC.
952	1184515026	Genotypes CT + TT is associated with increased clearance of tacrolimus in Kidney Transplantation as compared to genotype CC.
951	1184515022	Genotypes CT + TT is associated with increased clearance of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
950	1184515019	Genotypes CT + TT are associated with increased metabolism of tacrolimus in children with Kidney Transplantation as compared to genotype CC.
949	1184515016	Genotype CC is associated with decreased metabolism of tacrolimus in Kidney Transplantation.
948	1184515004	Genotypes CT + TT are associated with increased clearance of tacrolimus in people with HSCT as compared to genotype CC.
947	1184515001	Allele T is associated with increased metabolism of tacrolimus in people with Kidney Transplantation as compared to allele C.
946	1184514835	Genotypes CT + TT is associated with increased metabolism of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
945	1184514696	Genotype CT is associated with increased clearance of tacrolimus in liver transplantation as compared to genotype CC.
944	1184514668	Genotypes CT + TT is not associated with increased metabolism of tacrolimus in children with Kidney Transplantation as compared to genotype CC.
943	1184514665	Allele T is not associated with metabolism of tacrolimus in people with heart transplantation as compared to allele C.
942	1184514594	Genotypes CT + TT is associated with decreased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
941	1184514591	Genotype CC is associated with increased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to genotypes CT + TT.
940	1184514588	Genotype CC is associated with decreased clearance of tacrolimus in children with Kidney Transplantation as compared to genotype CT.
939	1184514585	Genotype CT is associated with increased clearance of tacrolimus in Kidney Transplantation as compared to genotype CC.
938	1184514582	Genotype TT is associated with increased clearance of tacrolimus in Kidney Transplantation as compared to genotype CC.
937	1184514579	Genotype TT is associated with increased clearance of tacrolimus in Kidney Transplantation as compared to genotype CC.
936	1184514573	Genotypes CT + TT is associated with increased clearance of tacrolimus in Kidney Transplantation as compared to genotype CC.
935	1184514570	Genotypes CT + TT is associated with increased metabolism of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
934	1184514567	Genotype CC is associated with decreased clearance of tacrolimus in people with Kidney Transplantation as compared to genotypes CT + TT.
933	1184514561	Genotypes CT + TT is associated with increased metabolism of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
932	1184514555	Genotypes CT + TT is associated with increased metabolism of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
931	1184514546	Genotypes CT + TT is associated with increased metabolism of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
930	1184514543	Genotypes CT + TT is associated with increased metabolism of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
929	1184514540	Genotypes CT + TT is associated with increased metabolism of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
928	1184514537	Genotypes CT + TT are associated with increased clearance of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
927	1184514534	Genotype CT is associated with increased clearance of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
926	1184514528	Genotypes CT + TT are associated with increased metabolism of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
925	1184514519	Allele C is associated with decreased metabolism of tacrolimus in people with Kidney Transplantation as compared to allele T.
924	1184514516	Allele C is associated with decreased metabolism of tacrolimus in people with Kidney Transplantation as compared to allele T.
923	1184514513	Genotypes CT + TT are associated with increased metabolism of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
922	1184514507	Genotypes CT + TT are associated with increased metabolism of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
921	1184514504	Allele T is associated with increased metabolism of tacrolimus in people with Kidney Transplantation as compared to allele C.
920	1184514498	Genotype CT is associated with increased metabolism of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
919	1184470313	Genotype CC is associated with decreased metabolism of tacrolimus in people with Kidney Transplantation as compared to genotypes CT + TT.
918	1183700136	Genotype CT is associated with increased metabolism of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
917	1183698721	Genotype CC is associated with decreased metabolism of tacrolimus in people with Kidney Transplantation as compared to genotype CT.
916	1183698005	Genotype CC is not associated with metabolism of tacrolimus in people with Kidney Transplantation as compared to genotypes CT + TT.
915	1183697938	Genotype CC is associated with decreased metabolism of tacrolimus in people with Kidney Transplantation as compared to genotypes CT + TT.
914	1183690054	Genotypes CT + TT is associated with increased metabolism of tacrolimus in healthy individuals as compared to genotype CC.
913	1183684051	Genotypes CT + TT are associated with increased metabolism of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
912	1183533912	Genotype CC is associated with decreased clearance of tacrolimus in children with Kidney Transplantation as compared to genotype CT.
911	1183533896	Genotype CT is associated with increased clearance of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
910	1183533891	Genotype TT is associated with increased clearance of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
909	769174170	Genotype CC is associated with decreased clearance of tacrolimus in children with Kidney Transplantation as compared to genotypes CT + TT.
908	769172716	Allele C is not associated with trough concentrations of tacrolimus in people with Kidney Transplantation.
907	827813909	Allele C is associated with decreased clearance of tacrolimus in people with Kidney Transplantation as compared to allele T.
906	827812467	Genotype CC is associated with decreased metabolism of tacrolimus in people with Kidney Transplantation as compared to genotypes CT + TT.
905	827698684	Genotypes CT + TT are associated with increased clearance of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
904	827698515	Genotypes CT + TT are associated with decreased trough concentrations when treated with tacrolimus in people with Kidney Transplantation as compared to genotype CC.
903	982047183	Genotype CC is not associated with clearance of tacrolimus in people with Kidney Transplantation as compared to genotypes CT + TT.
902	982047178	Genotype CC is not associated with clearance of tacrolimus in people with Kidney Transplantation as compared to genotype CT.
901	981858994	Genotype CC is associated with decreased metabolism of tacrolimus in people with Kidney Transplantation as compared to genotypes CT + TT.
900	981858976	Genotype CC is associated with decreased metabolism of tacrolimus in people with Kidney Transplantation as compared to genotypes CT + TT.
899	1448994558	CYP3A5 poor metabolizers are associated with increased concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 intermediate metabolizers.
898	PA166104983	Annotation of DPWG Guideline for tacrolimus and CYP3A5
897	PA166124619	Annotation of CPIC Guideline for tacrolimus and CYP3A5
617	1184515204	CYP3A5 1/1 + 1/3 is associated with increased clearance of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 3/3.
616	1183945249	CYP3A5 1/3 is associated with increased clearance of tacrolimus in human liver microsomes as compared to CYP3A5 3/3.
615	1184515509	CYP3A5 3 is associated with increased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 1.
614	1183699855	CYP3A5 7 is associated with increased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 1.
613	1183699837	CYP3A5 3 is associated with increased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 1.
612	1183699846	CYP3A5 6 is associated with increased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 1.
611	1451118200	CYP3A5 3/3 + 6/6 + 7/7 + 3/6 + 3/7 + 6/7 (assigned as poor metabolizer phenotype) are associated with decreased metabolism of tacrolimus in people with lung transplantation as compared to CYP3A5 1/1 + 1/3 + 1/6 + 1/7 (assigned as intermediate metabolizer and normal metabolizer phenotype) .
610	1450415351	CYP3A5 3/3 is associated with increased dose-adjusted trough concentrations of tacrolimus in people with lung transplantation as compared to CYP3A5 1/1 + 1/3.
609	1450377052	CYP3A5 3/3 is associated with decreased clearance of tacrolimus in people with heart transplantation as compared to CYP3A5 1/3 + 1/1.
608	1450372870	CYP3A5 1/3 is associated with increased metabolism of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 3/3.
607	1450372838	CYP3A5 1 is associated with increased clearance of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 3.
606	1449750499	CYP3A5 3/3 is associated with decreased metabolism of tacrolimus in people with heart transplantation as compared to CYP3A5 1/1 + 1/3.
605	1449749618	CYP3A5 1/1 + 1/3 are associated with decreased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 3/3.
604	1449749340	CYP3A5 3/3 is associated with increased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 1/3.
603	1449748903	CYP3A5 1/1 + 1/3 is associated with decreased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 3/3.
602	1449748829	CYP3A5 1/1 + 1/3 are associated with increased metabolism of tacrolimus in people with heart transplantation as compared to CYP3A5 3/3.
601	1449748260	CYP3A5 1/1 + 1/3 are associated with decreased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 3/3.
600	1449748012	CYP3A5 3/3 is associated with decreased metabolism of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 1/1 + 1/3.
599	1449183240	CYP3A5 1 is not associated with metabolism of cyclosporine or tacrolimus in people with Kidney Transplantation as compared to CYP3A5 3.
598	1449171352	CYP3A5 3/3 is associated with increased concentrations of tacrolimus in children with Kidney Transplantation as compared to CYP3A5 1/1 + 1/3.
597	1449170428	CYP3A5 1/1 + 1/3 + 1/6 is associated with increased concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 3/3 + 3/6 + 6/6.
596	1449170380	CYP3A5 1/1 + 1/3 is associated with increased clearance of tacrolimus in children with Kidney Transplantation as compared to CYP3A5 3/3.
595	1449165818	CYP3A5 3/3 is associated with increased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 1/1 + 1/3.
594	1449004146	CYP3A5 1 is associated with decreased concentrations of cyclosporine or tacrolimus in people with Kidney Transplantation as compared to CYP3A5 3.
593	1448820606	CYP3A5 3/3 is associated with decreased metabolism of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 1/1 + 1/3.
592	1448819453	CYP3A5 3/3 is associated with increased dose-adjusted trough concentrations of tacrolimus in children with Kidney Transplantation as compared to CYP3A5 1/1 + 1/3.
591	1448640944	CYP3A5 3/3 is associated with increased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 1/1 + 1/3.
590	1448602336	CYP3A5 3/3 is associated with decreased clearance of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 1/3.
589	1448569672	CYP3A5 1/1 + 1/3 is associated with increased metabolism of tacrolimus in children with Kidney Transplantation as compared to CYP3A5 3/3.
588	1448530624	CYP3A5 1/3 is associated with decreased dose-adjusted trough concentrations of tacrolimus in children with Kidney Transplantation as compared to CYP3A5 3/3.
587	1448525595	CYP3A5 1/1 + 1/3 are associated with increased metabolism of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 3/3.
586	1448285727	CYP3A5 1/1 + 1/3 are associated with increased metabolism of tacrolimus in children with Kidney Transplantation as compared to CYP3A5 3/3.
585	1448285615	CYP3A5 3/3 is associated with increased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 1/1 + 1/3.
584	1448267244	CYP3A5 3 + 6 + *7 are associated with decreased clearance of tacrolimus in people with Kidney Transplantation.
583	1447949204	CYP3A5 3/3 is associated with increased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 1/3.
582	1447947447	CYP3A5 1/1 is not associated with concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 1/3 + 3/3.
581	1447947435	CYP3A5 1/1 is associated with decreased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 3/3.
580	1447946634	CYP3A5 3 is associated with increased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 1.
579	1447674691	CYP3A5 1/1 + 1/3 is associated with decreased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 3/3.
578	1447674595	CYP3A5 3/3 is associated with increased concentrations of tacrolimus in people with hematopoietic stem cell transplantation as compared to CYP3A5 1/1 + 1/3.
577	1447674267	CYP3A5 1/3 is associated with decreased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 3/3.
576	1447674165	CYP3A5 1/1 + 1/3 is associated with decreased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 3/3.
575	1447673635	CYP3A5 3/3 is associated with decreased metabolism of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 1/3.
574	1447520795	CYP3A5 3/3 is associated with increased dose-adjusted trough concentrations of sirolimus or tacrolimus in people with Kidney Transplantation as compared to CYP3A5 1/1 + 1/3.
573	1447520652	CYP3A5 1 is associated with decreased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 3/*3.
572	1445584925	CYP3A5 3/3 is associated with increased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 1/1 + 1/3.
571	1445164647	CYP3A5 3/3 is associated with increased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 1/1 + 1/3.
570	1444934203	CYP3A5 1/1 + 1/3 is associated with increased clearance of tacrolimus in children with Kidney Transplantation as compared to CYP3A5 3/3.
569	1444706282	CYP3A5 3/3 is associated with increased concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 1/1 + 1/3.
568	1185023177	CYP3A5 1/3 + 3/3 is associated with increased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 1/1.
567	1184515311	CYP3A5 1/1 + 1/3 is not associated with metabolism of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 3/3.
566	1184515210	CYP3A5 3/3 is associated with decreased clearance of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 1/1 + 1/3.
565	1184515192	CYP3A5 1/1 + 1/3 is associated with increased clearance of tacrolimus in people with lung transplantation as compared to CYP3A5 3/3.
564	1184515125	CYP3A5 1/1 + 1/3 is not associated with blood concentration of tacrolimus in people with liver transplantation as compared to CYP3A5 3/3.
563	1184515084	CYP3A5 1/1 + 1/3 is not associated with metabolism of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 3/3.
562	1184515044	CYP3A5 1/1 + 1/3 is associated with decreased trough concentrations of tacrolimus in children with heart transplantation as compared to CYP3A5 3/3.
561	1184515038	CYP3A5 1/3 + 3/3 is associated with increased blood concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 1/1.
560	1184514654	CYP3A5 3/3 is associated with decreased metabolism of tacrolimus in children with Kidney Transplantation as compared to CYP3A5 1/1 + 1/3.
559	1184471417	CYP3A5 1/1 + 1/3 is associated with decreased dose-adjusted trough concentrations of tacrolimus in children with liver transplantation as compared to CYP3A5 3/3.
558	1184471300	CYP3A5 3/3 is associated with increased trough concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 1/3.
557	1184471246	CYP3A5 3/3 is associated with increased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 1/3.
556	1184471077	CYP3A5 3/3 is not associated with likelihood of achieving target concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 1/1 + 1/3.
555	1184470999	CYP3A5 3/3 is associated with increased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 1/1 + 1/3.
554	1184470932	CYP3A5 1/1 + 1/3 is associated with increased clearance of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 3/3.
553	1184470893	CYP3A5 3/3 is associated with decreased metabolism of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 1/1 + 1/3.
552	1184470790	CYP3A5 1/1 + 1/3 is associated with increased metabolism of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 3/3.
551	1184470726	CYP3A5 3/3 is associated with increased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 1/3.
550	1184470680	CYP3A5 1/1 + 1/3 is associated with decreased dose-adjusted trough concentrations of tacrolimus in children with Kidney Transplantation as compared to CYP3A5 3/3.
549	1184470264	CYP3A5 3/3 is associated with increased likelihood of achieving target concentrations of tacrolimus in children with Kidney Transplantation as compared to CYP3A5 1/1 + 1/3.
548	1184085726	CYP3A5 3/3 is associated with increased tacrolimus plasma trough levels and severely diminished tacrolimus clearance when treated with tacrolimus as compared to CYP3A5 1/1.
547	1183959875	CYP3A5 1/1 + 1/3 is not associated with clearance of tacrolimus in children with hemopoietic stem cell transplant as compared to CYP3A5 3/3.
546	1183954989	CYP3A5 1/1 + 1/3 is associated with increased metabolism of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 3/3.
545	1183699984	CYP3A5 1/3 is associated with increased clearance of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 3/3.
544	1183699973	CYP3A5 1/1 is associated with increased clearance of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 3/3.
543	1183693321	CYP3A5 3/3 is associated with decreased clearance of tacrolimus in people with Kidney Transplantation as compared to CYP3A5 1/1 + 1/3.
542	1451714340	Genotypes CT + TT are associated with increased clearance of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
541	1451415515	Genotypes CT + TT are associated with increased concentrations of tacrolimus in people with Kidney Transplantation as compared to genotype CC.
540	1448106854	Allele C is associated with increased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to allele T.
539	1448112425	Genotypes CT + TT are associated with decreased dose-adjusted trough concentrations of tacrolimus in people with heart transplantation as compared to genotype CC.
538	1449747826	Genotype CC is associated with increased dose-adjusted trough concentrations of tacrolimus in people with liver transplantation as compared to genotypes CT + TT.
537	1449575706	Genotype TT is associated with increased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to genotypes CC + CT.
536	1448603528	Genotype CC is associated with increased dose-adjusted trough concentrations of tacrolimus in people with lung transplantation as compared to genotypes CT + TT.
535	1448597114	Genotype CC is associated with increased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to genotypes CT + TT.

临床病史

id	类型	评论
1580	Update	Added PMID 33512723 to evidence
1579	Update	Added DPWG guideline.
1578	Update	Added PMID 32843687 to evidence
1577	Update	CA score added as part of scoring system release. LOE assigned following curator review.
1576	Update	Added supporting VAs for patients receiving a liver transplant with the same CYP3A5 genotype. Edited phenotype descriptions.
1575	Update	Added CPIC guideline and edited phenotype descriptions
1574	Create	Created

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