氟尿嘧啶,临床注释-2,变异和临床注释数据

id	等位基因	注释文本
1094	TT	Both variants of rs1801160 are assigned normal function by CPIC. Patients with the TT genotype and cancer who are treated with fluorouracil, a fluoropyrimidine-based chemotherapy, may not have altered risk of drug toxicity as compared to patients with the CT or CC genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.
1093	CT	Both variants of rs1801160 are assigned normal function by CPIC. Patients with the CT genotype and cancer who are treated with fluorouracil, a fluoropyrimidine-based chemotherapy, may not have altered risk of drug toxicity as compared to patients with the CC or TT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.
1092	CC	Both variants of rs1801160 are assigned normal function by CPIC. Patients with the CC genotype and cancer who are treated with fluorouracil, a fluoropyrimidine-based chemotherapy, may not have altered risk of drug toxicity as compared to patients with the CT or TT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.

等位基因

注释文本

Both variants of rs1801160 are assigned normal function by CPIC. Patients with the TT genotype and cancer who are treated with fluorouracil, a fluoropyrimidine-based chemotherapy, may not have altered risk of drug toxicity as compared to patients with the CT or CC genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.

1093

Both variants of rs1801160 are assigned normal function by CPIC. Patients with the CT genotype and cancer who are treated with fluorouracil, a fluoropyrimidine-based chemotherapy, may not have altered risk of drug toxicity as compared to patients with the CC or TT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.

1092

Both variants of rs1801160 are assigned normal function by CPIC. Patients with the CC genotype and cancer who are treated with fluorouracil, a fluoropyrimidine-based chemotherapy, may not have altered risk of drug toxicity as compared to patients with the CT or TT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.

id	证据的ID	总结
2047	1447945384	Genotype CC is not associated with Drug Toxicity when treated with fluorouracil in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to genotype CT.
2046	1449162055	Genotypes CT + TT is associated with increased risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Colonic Neoplasms as compared to genotype CC.
2045	981394398	Genotype CT is associated with increased likelihood of Drug Toxicity when treated with fluorouracil in people with Neoplasms as compared to genotype CC.
2044	1450954760	Allele T is not associated with severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms as compared to allele C.
2043	1450953980	Allele T is not associated with severity of Drug Toxicity when treated with fluorouracil.
2042	1450952660	Genotype TT is associated with increased likelihood of Drug Toxicity when treated with fluorouracil in people with Neoplasms, Breast Neoplasms, Colonic Neoplasms, Rectal Neoplasms or Stomach Neoplasms as compared to genotype CC.
2041	1447987436	Genotype CT are not associated with Drug Toxicity when treated with capecitabine, fluorouracil or s 1 (combination) in people with Stomach Neoplasms as compared to genotype CC.
2040	1449732030	Genotypes CT + TT are associated with increased risk of Drug Toxicity and Neutropenia when treated with capecitabine or fluorouracil in people with Colorectal Neoplasms as compared to genotype CC.
2039	PA166122686	Annotation of CPIC Guideline for fluorouracil and DPYD
896	1450372243	Genotypes CT + TT is associated with increased risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms as compared to genotype CC.
895	1450371918	Genotypes CT + TT is associated with increased risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms as compared to genotype CC.
894	1448997530	Genotype TT is associated with Drug Toxicity when treated with fluorouracil.
893	1448262721	Allele T is not associated with severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms.
892	1447949996	Allele T is associated with increased likelihood of Drug Toxicity when treated with fluorouracil in people with Colonic Neoplasms or Colorectal Neoplasms as compared to allele C.
891	1447945619	Allele T is not associated with severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms as compared to allele C.

证据的ID

总结

2047

1447945384

Genotype CC is not associated with Drug Toxicity when treated with fluorouracil in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to genotype CT.

2046

1449162055

Genotypes CT + TT is associated with increased risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Colonic Neoplasms as compared to genotype CC.

2045

981394398

Genotype CT is associated with increased likelihood of Drug Toxicity when treated with fluorouracil in people with Neoplasms as compared to genotype CC.

2044

1450954760

Allele T is not associated with severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms as compared to allele C.

2043

1450953980

Allele T is not associated with severity of Drug Toxicity when treated with fluorouracil.

2042

1450952660

Genotype TT is associated with increased likelihood of Drug Toxicity when treated with fluorouracil in people with Neoplasms, Breast Neoplasms, Colonic Neoplasms, Rectal Neoplasms or Stomach Neoplasms as compared to genotype CC.

2041

1447987436

Genotype CT are not associated with Drug Toxicity when treated with capecitabine, fluorouracil or s 1 (combination) in people with Stomach Neoplasms as compared to genotype CC.

2040

1449732030

Genotypes CT + TT are associated with increased risk of Drug Toxicity and Neutropenia when treated with capecitabine or fluorouracil in people with Colorectal Neoplasms as compared to genotype CC.

2039

PA166122686

Annotation of CPIC Guideline for fluorouracil and DPYD

896

1450372243

Genotypes CT + TT is associated with increased risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms as compared to genotype CC.

895

1450371918

Genotypes CT + TT is associated with increased risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms as compared to genotype CC.

894

1448997530

Genotype TT is associated with Drug Toxicity when treated with fluorouracil.

893

1448262721

Allele T is not associated with severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms.

892

1447949996

Allele T is associated with increased likelihood of Drug Toxicity when treated with fluorouracil in people with Colonic Neoplasms or Colorectal Neoplasms as compared to allele C.

891

1447945619

Allele T is not associated with severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms as compared to allele C.

id	类型	评论
1573	Update	CA score added as part of scoring system release. LOE assigned following curator review.
1572	Update	Attached CPIC guideline and removed override. Added CPIC function and modified text.
1571	Create	Created

类型

1573

Update

CA score added as part of scoring system release. LOE assigned following curator review.

1572

Update

Attached CPIC guideline and removed override. Added CPIC function and modified text.

1571

Create

Created