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当前位置:药药网 / 数据中心 / 临床注释-2,变异和临床注释数据
华法林
临床注释ID
655384733
药物名称(英)
warfarin
变异单倍型
rs7294
基因
VKORC1
证据级别
1B
水平覆盖
水平修饰符
Tier 1 VIP
表现型类别(英)
Dosage
表现型类别
剂量
分数
43.25
PMID计数
21
计数的证据
22
表现型
表现型(英)
最新日期
2021/11/19 0:00:00
URL
https://www.pharmgkb.org/clinicalAnnotation/655384733
专业人口(英)
专业人口
临床等位基因
id
等位基因
注释文本
1073
TT
Patients with the rs7294 TT genotype may require a higher dose as compared to patients with the CC genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also affect warfarin dose requirements.
1072
CT
Patients with the rs7294 CT genotype may require a higher dose of warfarin as compared to patients with the CC genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also affect warfarin dose requirements.
1071
CC
Patients with the rs7294 CC genotype may require a lower dose of warfarin as compared to patients with the CT or TT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also affect warfarin dose requirements.
临床证据
id
证据的ID
总结
3204
981500585
Allele T is associated with increased dose of warfarin in people with Myocardial Infarction as compared to allele C.
3203
981483987
Genotypes CT + TT are associated with increased dose of warfarin in people with mechanical heart valve replacement as compared to genotype CC.
3202
1451589762
Genotypes CT + TT are associated with increased dose of warfarin as compared to genotype CC.
3201
1451340144
Genotypes CT + TT are associated with increased dose of warfarin as compared to genotype CC.
1976
769277912
Genotype CT is associated with increased dose of warfarin as compared to genotype CC.
1975
827649690
Allele T is associated with increased dose of warfarin as compared to allele C.
1974
769277903
Genotype TT is associated with increased dose of warfarin as compared to genotypes CC + CT.
1973
1447519684
Genotypes CT + TT are associated with increased dose of warfarin as compared to genotype CC.
1972
1448276167
Genotype TT is associated with increased dose of warfarin as compared to genotype CC.
1971
1450979280
Allele T is associated with decreased dose of warfarin as compared to allele C.
1970
1444694686
Genotype CC is associated with decreased concentrations of warfarin in people with heart valve replacement as compared to genotypes CT + TT.
1969
1444694676
Genotype CC is not associated with dose of warfarin in people with heart valve replacement as compared to genotypes CT + TT.
1968
1185002294
Allele T is associated with increased dose of warfarin as compared to allele C.
1967
1184756163
Allele T is associated with increased dose of warfarin in people with heart valve replacement as compared to allele C.
1966
1184483453
Allele C is associated with decreased dose of warfarin as compared to allele T.
1965
1184472447
Allele T is associated with increased dose of warfarin as compared to allele C.
1964
1183704904
Genotype CC is associated with decreased dose of warfarin as compared to genotypes CT + TT.
1963
1183697701
Genotypes CT + TT is associated with increased dose of warfarin in people with Cardiovascular Diseases as compared to genotype CC.
1962
1183697222
Genotype TT is associated with increased dose of warfarin as compared to genotypes CC + CT.
1961
655388073
Allele T is associated with increased dose of warfarin.
1960
827567329
Allele C is associated with decreased dose of warfarin as compared to allele T.
1959
982034243
Allele T is associated with increased dose of warfarin as compared to allele C.
临床病史
id
类型
评论
1550
Update
Added PMIDs 31869433 and 31114289 to evidence
1549
Update
CA score added as part of scoring system release. LOE assigned following curator review.
1548
Update
updated text
1547
Update
Removed links to haplotypes.
1546
Update
Reviewed.
1545
Update
Added PMID 21635147,
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