别嘌醇,临床注释-2,变异和临床注释数据

别嘌醇

临床注释ID

1183701210

药物名称(英)

allopurinol

变异单倍型

HLA-A*33:03

基因

HLA-A

证据级别

2B

水平覆盖

水平修饰符

表现型类别(英)

Toxicity

表现型类别

毒性

分数

12.75

PMID计数

7

计数的证据

8

表现型

药物超敏反应；史蒂文斯-约翰逊综合征

表现型(英)

Drug Hypersensitivity;Stevens-Johnson Syndrome

最新日期

2021/3/24 0:00:00

URL

https://www.pharmgkb.org/clinicalAnnotation/1183701210

专业人口(英)

专业人口

临床等位基因

id	等位基因	注释文本
795	*33:03	Patients with one or two copies of the HLA-A33:03 allele who are treated with allopurinol may have an increased risk of severe cutaneous adverse reactions (SCARs) as compared to patients with no HLA-A33:03 alleles or negative for the HLA-A33:03 test. This allele has been shown to be in linkage disequilibrium with the HLA-B58:01 allele in some populations, which has a strong association with allopurinol-induced SCARs. Other genetic and clinical factors may also influence risk of allopurinol-induced adverse reactions.

临床证据

id	证据的ID	总结
2263	1184757286	HLA-A *33:01:01 is not associated with increased risk of erythema exudativum multiforme and Stevens-Johnson Syndrome when treated with allopurinol in people with Hyperuricemia.
2262	1184756788	HLA-A *33:03 is not associated with increased risk of Exanthema when treated with allopurinol in people with Kidney Failure, Chronic.
2261	1184756745	HLA-A *33:03 is associated with increased risk of severe cutaneous adverse reactions when treated with allopurinol in people with Kidney Failure, Chronic.
2260	1184755056	HLA-A *33:03 is associated with increased risk of severe cutaneous adverse reactions when treated with allopurinol.
2259	1184747209	HLA-A *33:03 is associated with increased risk of severe cutaneous adverse reactions when treated with allopurinol.
2258	1184467904	HLA-A *33:03:01 is associated with increased risk of severe cutaneous adverse reactions when treated with allopurinol.
2257	1183685091	HLA-A *33:01:01 is associated with Drug Hypersensitivity when treated with allopurinol in men.
2256	827919462	HLA-A *33:03 is associated with increased likelihood of Stevens-Johnson Syndrome or Epidermal Necrolysis, Toxic when treated with allopurinol in people with Drug Hypersensitivity.

临床病史

id	类型	评论
1176	Update	CA score added as part of scoring system release. LOE assigned following curator review.
1175	Update	Minor edits to phenotype descriptions

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