id	等位基因	注释文本
1369	GG	Patients with the rs118192122 GG genotype may have a decreased, but not absent, risk for malignant hyperthermia based on this variant when treated with volatile anesthetics (desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane) and/or succinylcholine as compared to patients with the AG or AA genotype. Other genetic or clinical factors may also influence the risk for malignant hyperthermia.
1368	AG	Patients with the rs118192122 AG genotype may develop malignant hyperthermia when treated with volatile anesthetics (desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane) and/or succinylcholine as compared to patients with the GG genotype. Other genetic or clinical factors may also influence the risk for malignant hyperthermia.
1367	AA	Patients with the rs118192122 AA genotype may develop malignant hyperthermia when treated with volatile anesthetics (desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane) and/or succinylcholine as compared to patients with the GG genotype. Other genetic or clinical factors may also influence the risk for malignant hyperthermia.

id	证据的ID	总结
3167	1449160148	Allele A is associated with Malignant Hyperthermia as compared to allele G.
3166	1447987594	Allele A is associated with increased risk of Malignant Hyperthermia as compared to allele G.
3165	1447961289	Genotype AG is associated with increased risk of Malignant Hyperthermia as compared to genotype GG.
3164	1447960670	Allele A is associated with increased risk of Malignant Hyperthermia as compared to allele G.
3163	1447952717	Allele A is associated with increased risk of Malignant Hyperthermia when exposed to volatile anesthetics as compared to allele G.
3162	1447952549	Genotype AG is associated with increased risk of Malignant Hyperthermia as compared to genotype GG.
3161	1447948719	Genotype AG is associated with increased risk of Malignant Hyperthermia as compared to genotype GG.
3160	1447946199	Genotype AG is associated with increased risk of Malignant Hyperthermia as compared to genotype GG.
3159	1447675923	Genotype AG is associated with increased risk of Malignant Hyperthermia as compared to genotype GG.
3158	1447674385	Genotype AG is associated with increased risk of Malignant Hyperthermia as compared to genotype GG.
3157	1447674319	Allele A is associated with increased risk of Malignant Hyperthermia and multi-core congenital myopathy as compared to allele G.
3156	1447673950	Allele A is associated with increased risk of Malignant Hyperthermia when exposed to methoxyflurane as compared to allele G.
3155	1447672469	Genotype AG is associated with Malignant Hyperthermia as compared to genotype GG.
3154	1447634061	Allele A is associated with Malignant Hyperthermia as compared to allele G.
3153	1445297392	Allele A is associated with increased risk of Malignant Hyperthermia when exposed to desflurane, enflurane, halothane, isoflurane, sevoflurane or succinylcholine as compared to allele G.
3152	1445297038	Allele A is associated with increased risk of Malignant Hyperthermia in people with increased creatine kinase level as compared to allele G.
3151	1444698012	Allele A is associated with increased risk of Malignant Hyperthermia as compared to allele G.
3150	1444697865	Allele A is associated with increased risk of Malignant Hyperthermia as compared to allele G.
3149	PA166180457	Annotation of CPIC Guideline for desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane, succinylcholine and CACNA1S, RYR1

id	类型	评论
1521	Update	CA score added as part of scoring system release. LOE assigned following curator review.
1520	Update	Drugs kept combined based on specifics of Malignant Hyperthermia diagnostics and CPIC guideline/EMHG inclusion.
1519	Update	Assigned LOE 1A since variant listed in recommendation of CPIC guideline
1518	Update	Added PMID 27382027
1517	Create

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