苯丙香豆素,临床注释-2,变异和临床注释数据

苯丙香豆素

临床注释ID

1451237940

药物名称(英)

phenprocoumon

变异单倍型

rs9923231

基因

VKORC1

证据级别

1A

水平覆盖

水平修饰符

Tier 1 VIP

表现型类别(英)

Dosage

表现型类别

剂量

分数

117

PMID计数

10

计数的证据

11

表现型

表现型(英)

最新日期

2021/3/24 0:00:00

URL

https://www.pharmgkb.org/clinicalAnnotation/1451237940

专业人口(英)

Pediatric

专业人口

儿科

临床等位基因

id	等位基因	注释文本
1363	TT	Patients with the rs9923231 TT genotype may require a lower dose when treated with phenprocoumon as compared to patients with the CC genotype. Other genetic and clinical factors may also influence phenprocoumon dose.
1362	CT	Patients with the rs9923231 CT genotype may require a lower dose when treated with phenprocoumon as compared to patients with the CC genotype. Other genetic and clinical factors may also influence phenprocoumon dose.
1361	CC	Patients with the rs9923231 CC genotype may require a higher dose when treated with phenprocoumon as compared to patients with the TT or CT genotype. Other genetic and clinical factors may also influence phenprocoumon dose.

临床证据

id	证据的ID	总结
3137	1448259259	Allele T is associated with dose of acenocoumarol or phenprocoumon.
3136	1448255689	Genotypes CT + TT are associated with decreased dose of phenprocoumon as compared to genotype CC.
3135	1043858478	Genotype TT is associated with decreased dose of phenprocoumon as compared to genotypes CC + CT.
3134	1043818234	Genotype TT is associated with decreased dose of phenprocoumon as compared to genotypes CT + TT.
3133	982046650	Genotype CC is associated with increased dose of phenprocoumon as compared to genotypes CT + TT.
3132	1444707853	Genotypes CT + TT are associated with decreased dose of phenprocoumon as compared to genotype CC.
3131	1444707757	Genotypes CT + TT are associated with decreased dose of phenprocoumon as compared to genotype CC.
3130	1444707652	Genotype TT is associated with decreased dose of phenprocoumon as compared to genotypes CC + CT.
3129	1444707634	Genotypes CT + TT are associated with decreased dose of phenprocoumon as compared to genotype CC.
3128	827864542	Genotype TT is associated with decreased dose of phenprocoumon or warfarin as compared to genotype CC.
3127	PA166104940	Annotation of DPWG Guideline for phenprocoumon and VKORC1

临床病史

id	类型	评论
1512	Update	CA score added as part of scoring system release. LOE assigned following curator review.
1511	Update	added guideline as evidence, updated text
1510	Create	Created

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