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氟伐他汀
临床注释ID
1451666740
药物名称(英)
fluvastatin
变异单倍型
CYP2C9*1, CYP2C9*2, CYP2C9*3
基因
CYP2C9
证据级别
1A
水平覆盖
水平修饰符
Tier 1 VIP
表现型类别(英)
Metabolism/PK
表现型类别
代谢/PK
分数
107.625
PMID计数
5
计数的证据
11
表现型
表现型(英)
最新日期
2022/2/15 0:00:00
URL
https://www.pharmgkb.org/clinicalAnnotation/1451666740
专业人口(英)
专业人口
临床等位基因
id等位基因注释文本
1291 *3 The CYP2C9*3 allele is assigned as a no function allele by CPIC. Patients carrying the CYP2C9*3 allele in combination with a normal, a decreased, or no function allele may have decreased metabolism of fluvastatin as compared to patients with two normal function alleles. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence the metabolism of fluvastatin. This annotation only covers the pharmacokinetic relationship between CYP2C9 and fluvastatin and does not include evidence about clinical outcomes.
1290 *2 The CYP2C9*2 allele is assigned as a decreased function allele by CPIC. Patients carrying the CYP2C9*2 allele in combination with a normal, decreased, or no function allele may have decreased metabolism of fluvastatin as compared to patients with two normal function alleles. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence the metabolism of fluvastatin. This annotation only covers the pharmacokinetic relationship between CYP2C9 and fluvastatin and does not include evidence about clinical outcomes.
1289 *1 The CYP2C9*1 allele is assigned as a normal function allele by CPIC. Patients carrying CYP2C9*1 allele in combination with another normal function allele may have increased metabolism of fluvastatin as compared to patients carrying at least one copy of a decreased function or no function allele. Other genetic and clinical factors may also influence the metabolism of fluvastatin. This annotation only covers the pharmacokinetic relationship between CYP2C9 and fluvastatin and does not include evidence about clinical outcomes.
临床证据
id证据的ID总结
1244 1450823501 CYP2C9 *2 is associated with increased concentrations of fluvastatin in healthy individuals as compared to CYP2C9 *1/*1.
1243 1451666721 CYP2C9 *1/*3 is associated with increased concentrations of fluvastatin in healthy individuals as compared to CYP2C9 *1/*1.
1242 1451666701 CYP2C9 *1/*3 is associated with decreased metabolism of fluvastatin as compared to CYP2C9 *1/*1.
1241 1451666680 CYP2C9 *1/*3 is associated with increased concentrations of fluvastatin in healthy individuals as compared to CYP2C9 *1/*1.
1240 1450823485 CYP2C9 *3 is associated with increased concentrations of fluvastatin in healthy individuals as compared to CYP2C9 *1/*1.
1239 982037405 Genotype CC is not associated with response to fluvastatin in healthy individuals as compared to genotype AA.
1238 982037386 Genotype CC is associated with decreased metabolism of fluvastatin in healthy individuals as compared to genotype AA.
1237 982037414 Allele T is not associated with response to fluvastatin in healthy individuals as compared to allele C.
1236 982037396 Genotypes CT + TT are not associated with metabolism of fluvastatin in healthy individuals as compared to genotype CC.
1235 1450823480 Allele G is associated with increased concentrations of fluvastatin in healthy individuals as compared to allele A.
1234 PA166262341 Annotation of CPIC Guideline for fluvastatin and CYP2C9, SLCO1B1
临床病史
id类型评论
1414 Note Second curator check
1413 Update added guideline as evidence
1412 Create Created

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